CN114217003A

CN114217003A - Multidimensional high performance liquid chromatography separation system

Info

Publication number: CN114217003A
Application number: CN202210001014.XA
Authority: CN
Inventors: 孟信刚
Original assignee: Jingdezhen University
Current assignee: Jingdezhen University
Priority date: 2022-01-04
Filing date: 2022-01-04
Publication date: 2022-03-22
Anticipated expiration: 2042-01-04
Also published as: CN114217003B

Abstract

The invention belongs to the technical field of analytical instruments, and particularly relates to a multidimensional high-performance liquid chromatography separation system which comprises a base, wherein a box body is arranged at the top end of the base, a rotating cover plate is arranged on the back surface of the top end of the box body, the rotating cover plate and the box body are connected with each other through a rotating shaft, a drawing chute is arranged on the back surface of the inner cavity of the box body, a drawing plate is arranged in the inner cavity of the drawing chute, a linkage bottom plate is arranged at the bottom end of the front end surface of the drawing plate, a mixing part is arranged at the top end of the linkage bottom plate, fixed vertical plates are arranged on the left side and the right side of the top end of the linkage bottom plate, a locking part is arranged at the end, far away from each other, of the two groups of fixed vertical plates, an analysis part is arranged at the top end of the fixed vertical plates on the right side of the top end of the linkage bottom plate, and a liquid storage part is arranged on the front end surface of the drawing plate.

Description

Multidimensional high performance liquid chromatography separation system

Technical Field

The invention belongs to the technical field of analytical instruments, and particularly relates to a multidimensional high-performance liquid chromatography separation system.

Background

Natural products from plants, marine organisms, traditional Chinese medicines, bioengineering and the like become a source for innovation of innovative medicines, functional foods and novel fine chemicals, a separation and preparation technology of chemical components of the natural medicines including polypeptides and plant secondary metabolites is a key point and a difficulty point for research and development of the innovative medicines and also a key point for innovation of modern traditional Chinese medicines, and large-scale, repeatable and systematic separation and preparation of active components in the natural products is a key point for innovative new medicines based on the natural medicines.

In the technical process of separating and preparing chemical components of medicines, chromatographic separation system equipment is required to be used for chromatographic separation, and the existing chromatographic separation system equipment is inconvenient to take out internal instruments for maintenance in the long-time use process.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a multidimensional high performance liquid chromatography separation system which has the characteristic of being convenient for disassembling and maintaining internal instruments of chromatographic separation system equipment.

In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a multidimension high performance liquid chromatography piece-rate system, includes the base, the top of base is equipped with the box, the back is equipped with the rotation apron behind the top of box, rotate through pivot interconnect between apron and the box, the back is equipped with the pull spout behind the inner chamber of box, the inner chamber of pull spout is equipped with the pull board, the preceding terminal surface bottom of pull board is equipped with the linkage bottom plate, the top of linkage bottom plate is equipped with the mixed portion, the top left and right sides of linkage bottom plate all is equipped with fixed riser, and is two sets of the one end that fixed riser kept away from each other all is equipped with locking portion, is located fixed riser top on linkage bottom plate top right side is equipped with analysis portion, the preceding terminal surface of pull board is equipped with the stock solution portion.

As a preferred technical scheme of the invention, the mixing part comprises a rotating motor, the top end of a rotating shaft of the rotating motor is connected with a mixing tank, the top end of the mixing tank is provided with a rotating cover plate, the top end of the mixing tank is provided with a convex block, the top end of the convex block is provided with a transverse plate, the upper end and the lower end of the transverse plate are provided with threaded through holes, locking screw rods are arranged in the threaded through holes, the top end of the rotating cover plate is provided with a second rotating motor, the outer side of the rotating shaft of the second rotating motor is connected with a second rotating cover plate, the upper end and the lower end of the rotating cover plate are provided with liquid inlets, and the top end of the rotating cover plate is provided with a limit baffle.

According to a preferred technical scheme, the analysis portion comprises an electric telescopic rod, a linkage transverse plate is connected to the top end of the outer side of a telescopic shaft of the electric telescopic rod, a chromatographic data processing instrument is arranged at the top end of the linkage transverse plate, a detection rod is connected to the top end of the chromatographic data processing instrument, vertical plates are arranged on the front side and the rear side of the top end of the linkage transverse plate, threaded through holes are formed in the front end and the rear end of each of the two groups of vertical plates, connecting screws are arranged in the threaded through holes, and a display screen is connected to the right side of the chromatographic data processing instrument.

According to a preferable technical scheme, the locking portion comprises a U-shaped plate, an anti-tilting plate is arranged at the top end of the U-shaped plate, a drawing rod is arranged in an inner cavity of the U-shaped plate, a groove is formed in the outer side of the drawing rod, rotating rods are connected to the front end and the rear end of the inner cavity of the groove, a clamping plate is connected to the outer side of the rotating rod, through holes are formed in the upper end and the lower end of the clamping plate, and inserting columns are arranged in the through holes.

As a preferred technical scheme of the invention, the liquid storage part comprises a convex plate, a fixing column is arranged at the top end of the convex plate, a rotary table is arranged on the outer side of the fixing column, six groups of through holes are arranged at the upper end and the lower end of the rotary table, liquid storage tanks are arranged in the six groups of through holes, and a liquid outlet pipe is arranged at the bottom end of the rotary table.

As a preferable technical scheme of the invention, the top end of the mixing tank is provided with a rotary drum, and the rotary cover plate is fixedly connected with the rotary drum.

As a preferred technical scheme of the invention, the left side plate and the right side plate of the box body are respectively provided with an inserting hole matched with the diameter of the inserting column.

Compared with the prior art, the invention has the beneficial effects that:

1. the adoption rotates the apron, will rotate the apron and rotate and cover blending tank top end opening to with locking screw downstream and extrusion laminating rotation apron, will rotate the apron and fix the top at the blending tank, and rotate the motor through the second and rotate, drive the second and rotate the apron and cover the inlet, can avoid when not using the blending tank, debris get into the inside pollution that causes of blending tank, when needs are cleaned mixing tank inside, will rotate the apron and rotate and open mixing tank top end opening can.

2. After the linkage bottom plate is moved to the inner cavity top end of the box body, the pulling rod is pulled outwards, the clamping plate is rotated around the rotating rod, the clamping plate is attached to the outer side of the box body, the inserting column is inserted into the inserting column on the box body, the height of the linkage bottom plate can be fixed, and the linkage bottom plate can be conveniently detached to maintain an instrument inside the box body.

3. Adopt connecting screw, when needs maintain the chromatogram data processing appearance on the linkage diaphragm, can rotate connecting screw to the one end of keeping away from each other, make connecting screw disconnection and chromatogram data processing appearance between be connected, can take off the chromatogram data processing appearance fast and maintain.

4. Adopt the carousel, when needs are cleaned liquid storage portion inside, take out the carousel from the outside of fixed column to extract the liquid storage pot from the through-hole on the carousel, and pour water in to the drain pipe, can clean drain pipe and liquid storage pot fast.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the mixing section of the present invention;

FIG. 3 is a schematic view of an analysis section according to the present invention;

FIG. 4 is a schematic view of a locking portion according to the present invention;

FIG. 5 is a schematic view of the structure of the liquid storage part of the present invention.

In the figure: 1. a base; 2. a box body; 3. rotating the cover plate; 4. a rotating shaft; 5. a pull chute; 6. a drawing plate; 7. a linkage bottom plate; 8. a mixing section; 9. fixing the vertical plate; 10. a locking portion; 11. an analysis unit; 12. a convex plate; 13. fixing a column; 14. a turntable; 15. a liquid storage tank; 16. a liquid outlet pipe; 17. a liquid storage part; 18. rotating the motor; 19. a mixing tank; 20. rotating the cover plate; 21. a bump; 22. a transverse plate; 23. locking the screw rod; 24. a second rotating electric machine; 25. a liquid inlet; 26. a second rotating cover plate; 27. a limit baffle; 28. an electric telescopic rod; 29. a linkage transverse plate; 30. a chromatographic data processor; 31. a vertical plate; 32. connecting a screw rod; 33. a detection rod; 34. a display screen; 35. a U-shaped plate; 36. an anti-roll plate; 37. a pull rod; 38. rotating the rod; 39. a splint; 40. and (5) inserting the columns.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Examples

Referring to fig. 1-5, the present invention provides the following technical solutions: a multidimensional high performance liquid chromatography separation system comprises a base 1, a box body 2 is arranged at the top end of the base 1, a rotary cover plate 3 is arranged on the back surface of the top end of the box body 2, the rotary cover plate 3 and the box body 2 are mutually connected through a rotary shaft 4, a drawing chute 5 is arranged on the back surface of the inner cavity of the box body 2, a drawing plate 6 is arranged in the inner cavity of the drawing chute 5, a linkage bottom plate 7 is arranged at the bottom end of the front end surface of the drawing plate 6, a mixing part 8 is arranged at the top end of the linkage bottom plate 7, fixed vertical plates 9 are arranged on the left side and the right side of the top end of the linkage bottom plate 7, locking parts 10 are arranged at the ends of the two groups of fixed vertical plates 9 which are far away from each other, an analysis part 11 is arranged at the top end of the fixed vertical plate 9 on the right side of the top end of the linkage bottom plate 7, a liquid storage part 17 is arranged on the front end surface of the drawing plate 6, when an instrument in the box body 2 needs to be disassembled and maintained, the drawing plate 6 upwards in the inner cavity of the drawing chute 5, drive linkage bottom plate 7 upward movement to the inner chamber top of box 2, avoid box 2 overall structure fixed, be not convenient for take out the instrument and maintain.

Specifically, referring to fig. 1-2, in this embodiment, the mixing portion 8 includes a rotating motor 18, a mixing tank 19 is connected to a top end of a rotating shaft of the rotating motor 18, a liquid outlet is disposed at a bottom end of a front end surface of the mixing tank 19, a switch is disposed in the liquid outlet, liquid in the mixing tank 19 is poured out through the liquid outlet, a rotating cover plate 20 is disposed at a top end of the mixing tank 19, a protrusion 21 is disposed at a top end of the mixing tank 19, a horizontal plate 22 is disposed at a top end of the protrusion 21, threaded through holes are disposed at upper and lower ends of the horizontal plate 22, a locking screw 23 is disposed in the threaded through hole, a second rotating motor 24 is disposed at a top end of the rotating cover plate 20, a second rotating cover plate 26 is connected to an outer side of a rotating shaft of the second rotating motor 24, liquid inlets 25 are disposed at upper and lower ends of the rotating cover plate 20, a limit baffle 27 is disposed at a top end of the rotating cover plate 20, the opening of the mixing tank 19 is covered by the rotating cover plate 20, and the locking screw 23 moves downwards and extrudes and fits the rotating cover plate 20, the rotating cover plate 20 is fixed at the top end of the mixing tank 19, when liquid is required to be poured into the inner cavity of the mixing tank 19 for mixing, the second rotating motor 24 rotates to drive the second rotating cover plate 26 to rotate to open the top end opening of the liquid inlet 25, so that the liquid can be poured into the inner cavity of the mixing tank 19 through the liquid inlet 25, and the rotating motor 18 is started to drive the mixing tank 19 to mix the hydraulic pressure.

Specifically, referring to fig. 1-3, in this embodiment, the analysis portion 11 includes an electric telescopic rod 28, a linkage horizontal plate 29 is connected to the top end of the outer side of the telescopic shaft of the electric telescopic rod 28, a chromatographic data processing instrument 30 is disposed on the top end of the linkage horizontal plate 29, a detection rod 33 is connected to the top end of the chromatographic data processing instrument 30, the detection data of the detection rod 33 can be transmitted to the chromatographic data processing instrument 30, vertical plates 31 are disposed on the front and rear sides of the top end of the linkage horizontal plate 29, threaded through holes are disposed on the front and rear ends of the two sets of vertical plates 31, a connection screw 32 is disposed in the threaded through holes, a display screen 34 is connected to the right side of the chromatographic data processing instrument 30, the detection rod 33 can be driven to be inserted into the inner cavity of the mixing tank 19 by the lifting and the electric telescopic rod 28, the mixed liquid can be detected, the content of the detected component can be read out after the processing by the chromatographic data processing instrument 30, and the area of the chromatographic peak in the graph can be obtained, and passes the data to the display screen 34 for display.

Specifically, please refer to fig. 1-4, in this embodiment, the locking portion 10 includes a U-shaped plate 35, an anti-tilt plate 36 is disposed on the top of the U-shaped plate 35, a pull rod 37 is disposed in an inner cavity of the U-shaped plate 35, a groove is disposed on an outer side of the pull rod 37, rotating rods 38 are connected to front and rear ends of the inner cavity of the groove, clamping plates 39 are connected to outer sides of the rotating rods 38, through holes are disposed at upper and lower ends of the clamping plates 39, and inserting posts 40 are disposed in the through holes, after the linkage bottom plate 7 is moved to the top end of the inner cavity of the box 2, the pull rod 37 is pulled outwards, and the clamping plates 39 are rotated around the rotating rods 38, so that the clamping plates 39 are attached to the outer side of the box 2, and the inserting posts 40 are inserted into the inserting posts 40 on the box 2, so as to fix the height of the linkage bottom plate 7, and facilitate the detachment of an instrument inside the box 2.

Specifically, referring to fig. 1-5, in this embodiment, the liquid storage portion 17 includes a convex plate 12, a fixed column 13 is disposed at a top end of the convex plate 12, a rotary table 14 is disposed outside the fixed column 13, six sets of through holes are disposed at upper and lower ends of the rotary table 14, a liquid storage tank 15 is disposed in the six sets of through holes, a liquid outlet pipe 16 is disposed at a bottom end of the rotary table 14, a bottom end of the liquid outlet pipe 16 is located above the liquid inlet 25, an electromagnetic valve is disposed at a bottom end of the liquid storage tank 15, liquid in the liquid storage tank 15 can be poured into an inner cavity of the liquid outlet pipe 16 by controlling an opening of the electromagnetic valve, when the interior of the liquid storage portion 17 needs to be cleaned, the rotary table 14 is pulled out from the outer side of the fixed column 13, and the liquid storage tank 15 is pulled out of the through holes on the rotary table 14, so that cleaning can be performed.

Specifically, referring to fig. 1-2, in the embodiment, a rotating drum is disposed at the top end of the mixing tank 19, a rotating cover plate 20 is fixedly connected to the rotating drum, and the rotating cover plate 20 can rotate around the rotating drum.

Specifically, referring to fig. 1-4, in the present embodiment, the side plates on the left and right sides of the box body 2 are respectively provided with an insertion hole matching with the diameter of the insertion post 40, so that the insertion post 40 can be inserted into the insertion hole to fix the insertion post.

The working principle and the using process of the invention are as follows: when the multi-dimensional high performance liquid chromatography separation system is used, an electric appliance on the chromatography separation system equipment can be started through an external power supply, the liquid in the liquid storage tank 15 is poured into the inner cavity of the liquid outlet pipe 16 by controlling the opening of the electromagnetic valve on the liquid storage tank 15, and enters the inner cavity of the mixing tank 19 through the liquid outlet pipe 16, and then the second rotating motor 24 is controlled to rotate, so that the second rotating cover plate 26 closes the opening at the top end of the liquid inlet 25, the rotating motor 18 is started to rotate, fully mixing a plurality of groups of liquid, opening the liquid inlet 25 after the mixing is finished, controlling the electric telescopic rod 28 to move up and down, driving the detection rod 33 to be inserted into the inner cavity of the mixing tank 19, the mixed liquid is detected, and after being processed by the chromatographic data processor 30, the content of the detected component is read out, the area of a chromatographic peak in the graph is calculated, and the data is transmitted to the display screen 34 to be displayed and recorded.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A multidimensional high performance liquid chromatography separation system comprising a base (1), characterized in that: a box body (2) is arranged at the top end of the base (1), a rotary cover plate (3) is arranged on the back surface of the top end of the box body (2), the rotating cover plate (3) and the box body (2) are connected with each other through a rotating shaft (4), a drawing sliding groove (5) is arranged on the back of the inner cavity of the box body (2), a drawing plate (6) is arranged in the inner cavity of the drawing sliding groove (5), the bottom end of the front end surface of the drawing plate (6) is provided with a linkage bottom plate (7), the top end of the linkage bottom plate (7) is provided with a mixing part (8), the automatic feeding device is characterized in that fixed vertical plates (9) are arranged on the left side and the right side of the top end of the linkage bottom plate (7), two groups of locking portions (10) are arranged at one ends, far away from each other, of the fixed vertical plates (9), an analysis portion (11) is arranged at the top ends of the fixed vertical plates (9) on the right side of the top end of the linkage bottom plate (7), and a liquid storage portion (17) is arranged on the front end face of the drawing plate (6).

2. The multi-dimensional high performance liquid chromatography separation system of claim 1, wherein: mixing portion (8) is including rotating motor (18), the axis of rotation top of rotating motor (18) is connected with blending tank (19), the top of blending tank (19) is equipped with rotates apron (20), the top of blending tank (19) is equipped with lug (21), the top of lug (21) is equipped with diaphragm (22), the upper and lower both ends of diaphragm (22) are equipped with the screw thread through-hole, be equipped with locking screw (23) in the screw thread through-hole, the top of rotating apron (20) is equipped with second rotation motor (24), the axis of rotation outside that second rotated motor (24) is connected with the second and rotates apron (26), the upper and lower both ends of rotating apron (20) are equipped with inlet (25), the top of rotating apron (20) is equipped with limit baffle (27).

3. The multi-dimensional high performance liquid chromatography separation system of claim 1, wherein: analysis portion (11) include electric telescopic handle (28), the telescopic shaft outside top of electric telescopic handle (28) is connected with linkage diaphragm (29), the top of linkage diaphragm (29) is equipped with chromatogram data processing appearance (30), the top of chromatogram data processing appearance (30) is connected with detection stick (33), both sides all are equipped with riser (31) around the top of linkage diaphragm (29), and are two sets of both ends all are equipped with the screw thread through-hole around riser (31), all be equipped with connecting screw (32) in the screw thread through-hole, the right side of chromatogram data processing appearance (30) is connected with display screen (34).

4. The multi-dimensional high performance liquid chromatography separation system of claim 1, wherein: locking portion (10) are including U template (35), the top of U template (35) is equipped with prevents tilt plate (36), the inner chamber of U template (35) is equipped with pull pole (37), the outside of pull pole (37) is equipped with the recess, both ends are connected with dwang (38) around the recess inner chamber, the outside of dwang (38) is connected with splint (39), the upper and lower both ends of splint (39) are equipped with the through-hole, be equipped with peg graft post (40) in the through-hole.

5. The multi-dimensional high performance liquid chromatography separation system of claim 1, wherein: the liquid storage part (17) comprises a convex plate (12), a fixing column (13) is arranged at the top end of the convex plate (12), a rotary table (14) is arranged on the outer side of the fixing column (13), six groups of through holes are formed in the upper end and the lower end of the rotary table (14), a liquid storage tank (15) is arranged in each of the six groups of through holes, and a liquid outlet pipe (16) is arranged at the bottom end of the rotary table (14).

6. A multidimensional high performance liquid chromatography separation system as recited in claim 2, wherein: the top end of the mixing tank (19) is provided with a rotary drum, and the rotary cover plate (20) is fixedly connected with the rotary drum.

7. The multi-dimensional high performance liquid chromatography separation system of claim 4, wherein: the left side plate and the right side plate of the box body (2) are respectively provided with an inserting hole matched with the diameter of the inserting column (40).