CN114209950A - Dual-mode oxygen generator and oxygen supply method thereof - Google Patents
Dual-mode oxygen generator and oxygen supply method thereof Download PDFInfo
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- CN114209950A CN114209950A CN202111562400.8A CN202111562400A CN114209950A CN 114209950 A CN114209950 A CN 114209950A CN 202111562400 A CN202111562400 A CN 202111562400A CN 114209950 A CN114209950 A CN 114209950A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/42—Rate
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Abstract
The invention belongs to the technical field of medical equipment, and particularly relates to a dual-mode oxygen generator and an oxygen supply method thereof, wherein the oxygen generator comprises an oxygen generation unit, a gas storage tank, a pressure regulating valve, a flow meter, an oxygen concentration pressure monitoring unit, an oxygen outlet nozzle and a respiration monitoring unit; the oxygen generation unit is connected with the gas storage tank through a pipeline provided with a one-way valve; the oxygen concentration monitoring device comprises an oxygen storage tank, a pressure regulating valve, a flowmeter, an oxygen concentration pressure monitoring unit and an oxygen outlet nozzle, wherein the gas storage tank, the pressure regulating valve, the flowmeter, the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle are sequentially connected through a pipeline to form a main gas circuit, a first gas circuit branch point is arranged on the pipeline between the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle, the first gas circuit branch point is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit. The invention can integrate the common oxygen generator for continuous oxygen supply and the pulse oxygen generator for pulse oxygen supply into one machine, thereby doubling the applicable population of the machine.
Description
Technical Field
The invention belongs to the technical field of medical equipment, and particularly relates to a dual-mode oxygen generator and an oxygen supply method thereof.
Background
The oxygen generator is divided into two oxygen supply modes of continuous oxygen supply and pulse oxygen supply. The continuous constant flow oxygen supply can be realized only under the conditions of relatively low pressure and small pressure fluctuation during the continuous oxygen supply; in the case of pulse oxygen supply, which requires relatively high pressure and fluctuates from high to low, a certain amount of oxygen is supplied to the user in a single time in a short period of time.
Chinese utility model patent CN206566327U discloses an along with inhaling oxygen oxygenerator, uses ultrasonic gas sensor as the detecting element that detects the human body and breathe or breathe in the oxygenerator, and the control unit is according to the human body that ultrasonic gas sensor detected and breathes in corresponding data, makes oxygen produce the unit only when the human body breathes in just provide oxygen for the human body through the oxygen therapy pipeline, and does not provide oxygen for the human body at other times to the realization is along with inhaling the oxygen suppliment. However, the oxygen generator with oxygen absorption and supply of the patent still only has a pulse oxygen supply mode, and the single mode cannot deal with various use scenes; the pulse frequency is not adjustable, and the treatment effect is single; the oxygen generation efficiency is low and the oxygen generation concentration is low.
Disclosure of Invention
The invention aims to provide a dual-mode oxygen generator which can be applied in a wider range of situations. The continuous oxygen supply mode has the advantages of large flow, long endurance time, strong oxygen supply capacity and the like, and the system is matched with the pulse oxygen supply mode, so that the equivalent treatment effect of pulse oxygen supply can be greatly improved to a level far exceeding that of a common pulse oxygen generator.
In order to achieve the purpose, the invention adopts the following technical scheme:
a dual-mode oxygen generator comprises an oxygen generation unit, a gas storage tank, a pressure regulating valve, a flow meter, an oxygen concentration pressure monitoring unit, an oxygen outlet nozzle and a respiration monitoring unit;
the oxygen generation unit is connected with the gas storage tank through a pipeline provided with a one-way valve;
the oxygen concentration monitoring device comprises an oxygen storage tank, a pressure regulating valve, a flowmeter, an oxygen concentration pressure monitoring unit and an oxygen outlet nozzle, wherein the gas storage tank, the pressure regulating valve, the flowmeter, the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle are sequentially connected through a pipeline to form a main gas circuit, a first gas circuit branch point is arranged on the pipeline between the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle, the first gas circuit branch point is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit. The breath detection unit has the functions of on-off and micro flow detection, and has the function of detecting whether the human body inhales.
Furthermore, the oxygen generator also comprises an air resistor, a first on-off valve and a bypass path, wherein the air storage tank, the air resistor, the first on-off valve and the first air path branch point are sequentially connected through a pipeline to form the bypass path.
Preferably, a second gas path branch point is arranged on a pipeline between the oxygen concentration pressure monitoring unit and the flowmeter, and the second gas path branch point is connected with a third cut-off valve;
when the second gas circuit branch point is connected with the third cut-off valve, the first gas circuit branch point is not connected with the detection gas circuit.
In the invention, the first gas path branch point and the second gas path branch point can be connected by adopting a tee joint.
Preferably, the respiration monitoring unit is a second shut-off valve and a micro-flow sensor, or a differential pressure sensor.
Preferably, the oxygen concentration pressure monitoring unit is an oxygen concentration sensor, an oxygen pressure sensor, or an integrated sensor having a function of detecting oxygen concentration, oxygen flow, and respiratory microflow.
Preferably, a tank pressure sensor is arranged on the air storage tank.
The flowmeter has the function of adjusting the output flow, and also has the function of on-off when the flow is adjusted to be 0.
The air resistance is the centralized expression of the sum of the air resistances of the whole bypass air circuit, and the air quantity with fixed volume can be obtained by adding extra air resistance or not adding extra air resistance in the air circuit and is regarded as the equivalent air resistance of the air resistance.
The invention also provides an oxygen supply system which comprises the oximeter and the dual-mode oxygen generator, wherein the dual-mode oxygen generator and the oximeter are connected in parallel to the control unit.
The control unit used in the present invention may be a conventional control unit in the art and may be commercially available.
The invention also provides an oxygen supply method of the dual-mode oxygen generator, which comprises the following steps:
1) the oxygen generation unit continuously generates oxygen and conveys the generated oxygen to the gas storage tank for storage; providing a continuous oxygen supply mode or a pulse oxygen supply mode according to the needs of a user;
2) continuous oxygen supply mode:
closing the detection gas circuit and the respiration monitoring unit;
the air storage tank outputs a stable pressure constant flow air flow through a pressure regulating valve and a flowmeter, the stable pressure constant flow air flow is output to an oxygen concentration pressure monitoring unit, the oxygen concentration pressure monitoring unit detects the oxygen concentration and flow value of the constant flow air flow, and finally the detected oxygen flow is continuously supplied to a user through an oxygen outlet nozzle;
pulse oxygen supply mode:
when the pulse mode is switched, the detection gas circuit and the respiration monitoring unit are normally opened, and the flowmeter is firstly closed;
when the user breathes in, the air gets into from breathing monitoring unit's gas outlet, flow to the oxygen mouth through breathing monitoring unit back flow direction, it detects the flow of small air current to breathe monitoring unit this moment, the flowmeter is opened, breathe monitoring unit and close after delaying the uniform time, the tolerance major part of the fixed volume of flowmeter rear end is carried the oxygen mouth through oxygen concentration pressure monitoring unit, the air of discharging behind the small part through breathing monitoring unit, breathe monitoring unit and detect the concentration of output oxygen through the small part oxygen air current that flows through, carry the back flowmeter that finishes and close, breathe monitoring unit and open, get into next breathing cycle.
The invention also provides another oxygen supply method of the dual-mode oxygen generator, which comprises the following steps:
1) the oxygen generation unit continuously generates oxygen and conveys the generated oxygen to the gas storage tank for storage; providing a continuous oxygen supply mode or a pulse oxygen supply mode according to the needs of a user;
2) continuous oxygen supply mode:
closing the detection gas circuit and the respiration monitoring unit; closing the first on-off valve;
the gas storage tank outputs a pressure-stabilizing constant-flow gas flow through a pressure regulating valve and a flowmeter, the pressure-stabilizing constant-flow gas flow is output to an oxygen concentration pressure monitoring unit after passing through a first on-off valve, the oxygen concentration pressure monitoring unit detects the oxygen concentration and flow value of the constant-flow gas flow, and finally the detected oxygen flow is continuously supplied to a user through an oxygen outlet nozzle;
pulse oxygen supply mode:
when the pulse mode is switched, the detection gas circuit and the respiration monitoring unit are normally opened, and the flowmeter is closed;
when the user breathes in, the air gets into from breathing monitoring unit's gas outlet, flow to the oxygen mouth after monitoring unit is breathed, the monitoring unit that breathes detects the flow of small air current this moment, first on-off valve is opened, breathe monitoring unit and close after delaying the definite time, most rethread air resistance of tolerance through first on-off valve back fixed volume carries out the oxygen mouth, the air of discharging behind the monitoring unit is breathed to the subtotal, breathe monitoring unit and detect the concentration of output oxygen through the flowing subtotal oxygen air current, carry and finish the back first on-off valve and close, breathe monitoring unit and open, get into next respiratory cycle.
The flow meter is used for flow measurement and gas circuit on-off. It can also be replaced by a combination of a flow meter and an on-off valve with a single flow detection function.
The oxygen concentration sensor is used for detecting the oxygen concentration and the oxygen flow during continuous ventilation, and whether the oxygen nozzle is blocked or not can be judged by detecting the flow.
The oxygen concentration pressure monitoring unit has the function of monitoring the oxygen concentration, the oxygen flow and the oxygen flow pressure.
In the invention, the equivalent units of the main gas path flow meter part refer to: assuming that a plurality of devices are provided to adjust the regulated flow of the regulated air output from the pressure regulating valve to a desired constant flow, the devices have different structures, shapes and adjustment modes, but the desired constant flow of the regulated air can be obtained by the devices, such as: one device controls the output flow by a stepping motor, and the other device controls the output flow by a mechanical switch, so that the devices are all called equivalent units of the flowmeter.
In the invention, an equivalent method for outputting the fixed volume gas by the bypass circuit is as follows: assuming that a plurality of bypass gas circuits can provide gas with fixed volume along with the respiratory frequency, the gas resistance aperture, the on-off time of the on-off valve and the pressure in the gas storage tank are different, but the relationship of the three is still satisfied with the result obtained by the small-hole jet flow equation, and the result is still to output the gas with fixed volume satisfying the current respiratory frequency, such as: the on-off time of the on-off valve is constant, the pressure in the gas storage tank is constant, and the gas volume with the fixed volume meeting the current respiratory frequency is obtained by adjusting the size of the gas resistance aperture; or the air resistance aperture is constant, the on-off time of the on-off valve is constant, the air quantity with fixed volume meeting the current respiratory frequency is obtained by adjusting the pressure in the air storage tank, and the two methods for outputting the fixed volume air quantity are both called as equivalent methods of the first method for outputting the fixed volume air quantity.
The method for realizing the constant volume of the oxygen output by the invention is equivalent to the method for realizing the amount of the oxygen inhaled by the user in the inspiration phase in the continuous oxygen supply mode.
Compared with the corresponding technology, the invention has the beneficial effects that:
the invention can integrate the common oxygen generator for continuous oxygen supply and the pulse oxygen generator for pulse oxygen supply into one machine, thereby doubling the applicable population of the machine, simultaneously, different oxygen supply modes are suitable for different populations, but the applicable mode of a user can change along with the development of the state of an illness, the change of the environment or the change of the user.
Drawings
Fig. 1 is a schematic structural diagram of a dual-mode oxygen generator according to embodiment 1 of the present invention;
fig. 2 is a schematic structural diagram of a dual-mode oxygen generator according to embodiment 2 of the present invention;
fig. 3 is a schematic structural diagram of a dual-mode oxygen generator according to embodiment 3 of the present invention;
fig. 4 is a schematic structural diagram of a dual-mode oxygen generator according to embodiment 4 of the present invention;
fig. 5 is a schematic structural diagram of a dual-mode oxygen generator according to embodiment 5 of the present invention;
fig. 6 is a schematic structural view of a dual-mode oxygen generator combined oximeter in accordance with embodiment 6 of the present invention;
reference numerals:
1. an oxygen generation unit; 2. a one-way valve; 3. a gas storage tank; 4. a tank internal pressure sensor; 5. connecting a pipeline; 6. a pressure regulating valve; 7. a flow meter; 8. a user; 9. a first gas path branch point; 10. a second on-off valve; 11. a micro flow detection sensor; 12. an oxygen concentration pressure monitoring unit; 13. an oxygen outlet nozzle; 14. air resistance; 15. a first on-off valve; 16. a differential pressure sensor; 17. a pressure sensor; 18. a third shutoff valve; 19. an oximeter.
Detailed Description
The invention is described in further detail below with reference to the figures and the detailed description.
Example 1
As shown in fig. 1, a dual-mode oxygen generator comprises an oxygen generation unit 1, a gas storage tank 3, a pressure regulating valve 6, a flow meter 7, an oxygen concentration pressure monitoring unit 12, an oxygen outlet nozzle 13 and a respiration monitoring unit;
the oxygen generation unit 1 is connected with a gas storage tank 3 through a pipeline provided with a one-way valve 2;
the oxygen concentration monitoring device is characterized in that the gas storage tank 3, the pressure regulating valve 6, the flowmeter 7, the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13 are sequentially connected through the connecting pipeline 5 to form a main gas circuit, a first gas circuit branch point 9 is arranged on a pipeline between the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13, the first gas circuit branch point 9 is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit.
The respiration monitoring unit includes a second shut-off valve 10 and a micro flow detection sensor 11 connected by a pipe.
And the gas storage tank 3 is provided with a tank internal pressure sensor 4.
The oxygen concentration pressure monitoring unit adopts an oxygen concentration sensor.
The first gas path branch point 9 is connected by a tee.
The first gas path branch point 9 in the present embodiment may also be provided on a line between the flow meter 7 and the pressure regulating valve 6, and may also be provided on a line between the flow meter 7 and the oxygen concentration pressure monitoring unit 12.
In this embodiment, an on-off valve may be further disposed on the pipeline between the pressure regulating valve 6 and the flow meter 7 to implement a corresponding gas path on-off function.
The invention integrates two oxygen supply modes with contradiction points into one set of oxygen generation system;
the dual-mode oxygen generator of the embodiment comprises: one set of system oxygen unit, a gas holder and a gas access, system oxygen unit can last system oxygen and will prepare oxygen and carry the gas holder to store, gas access includes: a gas storage tank, a tank pressure sensor (detecting the pressure value of gas), a connecting pipeline, a pressure regulating valve, a flowmeter, an on-off valve (controlling the on-off of the connecting pipeline), a tee joint, a micro-flow detection sensor, an oxygen concentration sensor and an oxygen outlet nozzle, the pressure sensor in the tank detects the pressure in the gas storage tank, the gas outlet of the gas storage tank is connected with the pressure regulating valve through a connecting pipeline, the pressure regulating valve outputs the fluctuant pressure value in the gas storage tank to the airflow with a stable pressure value, the airflow is output to the flowmeter, the flowmeter is connected to the oxygen concentration sensor, the oxygen concentration sensor is connected to the air inlet end of the tee joint, one end of the tee joint is connected to the detection air path connected with the second cut-off valve and the micro flow detection sensor, the other end of the tee joint is connected to the oxygen outlet nozzle, the oxygen concentration sensor detects the oxygen concentration and the flow value of the constant flow airflow, and finally, the oxygen with the concentration up to the standard and the constant flow is conveyed to a user from the oxygen outlet nozzle.
When the equipment is in a continuous oxygen supply mode, a respiration detection loop formed by the second on-off valve and the micro-flow detection sensor is closed, the respiration detection loop does not work, the flowmeter is normally open, the pressure regulating valve is set to be a lower pressure value at the moment to output a fluctuating pressure value in the gas storage tank to be gas flow with a stable pressure value, the pressure-stabilizing gas flow of the flowmeter is regulated to be required constant flow gas flow and output to the oxygen concentration sensor, the oxygen concentration sensor detects the oxygen concentration and flow value of the constant flow gas flow, and finally the detected oxygen flow is continuously supplied to a user through the oxygen outlet nozzle;
when the equipment is switched to a pulse mode, the second on-off valve is normally opened, the flowmeter is temporarily closed, the pressure regulating valve is fully opened and does not play a role of regulating pressure any more, namely, the air storage tank is directly connected with the flowmeter, the flowmeter regulates an outlet to be a smaller aperture and serves as an air resistor with a fixed aperture, when a user inhales air, air enters from an air outlet of the micro-flow detection sensor, flows to the oxygen outlet nozzle through an air inlet of the micro-flow detection sensor after passing through the second on-off valve and the tee joint, at the moment, the micro-flow detection sensor detects the flow of micro air flow, the flowmeter is opened, the second on-off valve is closed after delaying for a certain time, most of the air flow with the fixed volume at the rear end of the flowmeter is conveyed to the oxygen outlet nozzle through a connecting pipeline, a small part of the air flows through the first air outlet of the tee joint and then is discharged into the air, and the micro-flow detection sensor detects the oxygen concentration of output oxygen through the small part of the flowing oxygen flow, after the delivery is finished, the flowmeter is temporarily closed, the second on-off valve is opened, and the next breathing cycle is started. The method is characterized in that: two oxygen supply modes are integrated on one set of gas circuit system.
Example 2
As shown in fig. 2, the dual-mode oxygen generator comprises an oxygen generation unit 1, a gas storage tank 3, a pressure regulating valve 6, a flow meter 7, an oxygen concentration pressure monitoring unit 12, an oxygen outlet nozzle 13 and a respiration monitoring unit;
the oxygen generation unit 1 is connected with a gas storage tank 3 through a pipeline provided with a one-way valve 2;
the oxygen concentration monitoring device is characterized in that the gas storage tank 3, the pressure regulating valve 6, the flowmeter 7, the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13 are sequentially connected through the connecting pipeline 5 to form a main gas circuit, a first gas circuit branch point 9 is arranged on a pipeline between the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13, the first gas circuit branch point 9 is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit.
The oxygen generator also comprises an air resistor 14, a first on-off valve 15 and a bypass path, wherein the air storage tank 3, the air resistor 14, the first on-off valve 15 and the first air path branch point 9 are sequentially connected through pipelines to form the bypass path. The respiration monitoring unit includes a second shut-off valve 10 and a micro flow detection sensor 11 connected by a pipe.
And the gas storage tank 3 is provided with a tank internal pressure sensor 4.
The oxygen concentration pressure monitoring unit adopts an oxygen concentration sensor.
The first gas path branch point 9 is connected by a tee.
In this embodiment, an on-off valve may be further disposed on the pipeline between the pressure regulating valve 6 and the flow meter 7 to implement a corresponding gas path on-off function.
In this embodiment, in order to reduce the complexity of pressure control of one gas passage, the whole gas passage system may be split into two gas passages with separate high and low pressures, the two gas passages are divided into a main gas passage and a bypass gas passage, the two gas passages operate independently, and the main gas passage can continuously deliver oxygen stored in the gas storage tank to a user; the air supply mode of the bypass circuit is to supply the oxygen stored in the air storage tank when a user inhales and stop supplying the oxygen when the user exhales. The main gas circuit comprises a gas storage tank, a tank pressure sensor (detecting the pressure value of gas), a pressure regulating valve and a connecting pipeline, the pressure regulating device comprises an on-off valve (controlling the on-off of a connecting pipeline), a flowmeter, an oxygen concentration sensor and an oxygen outlet nozzle, wherein the pressure sensor in the tank detects the pressure in the gas storage tank, the gas inlet end of a pressure regulating valve is connected with the gas storage tank and outputs a fluctuating pressure value in the gas storage tank into a gas flow with a stable pressure value, the stable pressure gas flow at the gas outlet end of the pressure regulating valve is conveyed to the gas inlet end of the flowmeter, the stable pressure gas flow is regulated by the gas outlet end of the flowmeter into a required constant flow gas flow and conveyed to the gas inlet end of the oxygen concentration sensor, the oxygen concentration sensor detects the oxygen concentration and flow value of the constant flow gas flow, and finally, the oxygen with standard concentration and constant flow is connected to the oxygen outlet nozzle from the gas outlet end of the oxygen concentration sensor and conveyed to a user, and the components are connected in series into a gas passage by using the connecting pipeline;
the bypass gas circuit comprises a gas storage tank, a tank pressure sensor (detecting the pressure value of gas), a connecting pipeline, a gas resistor, two on-off valves (controlling the on-off of the connecting pipeline), a tee joint, a micro-flow detection sensor and an oxygen outlet nozzle, wherein the tank pressure sensor detects the pressure in the gas storage tank, the gas storage tank is connected to the gas resistor through the connecting pipeline, the middle of the gas resistor controls the flow of high-pressure gas in the gas storage tank through a small hole with a constant area, the gas resistor is connected with a first on-off valve through the connecting pipeline, the switching time of the first on-off valve is controlled to output the gas flow with the fixed volume meeting the current respiratory frequency, the rear end of the first on-off valve is connected to a tee joint gas inlet, a first gas outlet of the tee joint is connected with the oxygen outlet nozzle, a second gas outlet of the tee joint is connected with a second on-off valve, the rear end of the second on-off valve is connected with the gas inlet of the micro-flow detection sensor, and the gas outlet of the micro-flow detection sensor is connected to the air, when a bypass circuit is used for ventilation, the flowmeter is normally closed (indicating that the main circuit is closed), the first on-off valve is closed first, the second on-off valve is opened, when a user inhales air, air enters from the air outlet of the micro flow detection sensor, the air flows to the oxygen outlet nozzle through the air inlet of the micro flow detection sensor after passing through the second on-off valve, at the moment, the micro flow detection sensor detects the flow of micro air flow, the first on-off valve is opened, the second on-off valve is closed after delaying for a certain time, most of the air flow with the fixed volume at the rear end of the first on-off valve is conveyed to the oxygen outlet nozzle through the first air outlet of the tee joint, a small part of the air flows into the oxygen outlet nozzle through the micro flow detection sensor, the micro flow detection sensor detects the oxygen concentration of output oxygen through the flowing small part of the oxygen flow, the first on-off valve is closed after the conveying is finished, the second on-off valve is opened, and the next breathing cycle is entered.
In the embodiment, two gas passages are connected in parallel at the front end of the oxygen outlet nozzle through a tee joint, and the oxygen outlet nozzle is characterized in that: when a continuous air supply mode is required, the first on-off valve and the second on-off valve of the bypass air path are closed, the bypass air path is closed, and the main air path works normally; when pulse oxygen supply is needed, the flowmeter of the main gas path is closed, the bypass gas path works normally, the output gas volume with fixed volume is equivalent to the oxygen volume inhaled by a user in the inspiration phase under the continuous oxygen supply mode, and the use efficiency of the oxygen is improved by 2-3 times; two oxygen supply gas circuits can share one set of oxygen generation unit, as shown in fig. 2.
Example 3
As shown in fig. 3, the dual-mode oxygen generator comprises an oxygen generation unit 1, a gas storage tank 3, a pressure regulating valve 6, a flow meter 7, an oxygen concentration pressure monitoring unit 12, an oxygen outlet nozzle 13 and a respiration monitoring unit;
the oxygen generation unit 1 is connected with a gas storage tank 3 through a pipeline provided with a one-way valve 2;
the oxygen concentration monitoring device is characterized in that the gas storage tank 3, the pressure regulating valve 6, the flowmeter 7, the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13 are sequentially connected through the connecting pipeline 5 to form a main gas circuit, a first gas circuit branch point 9 is arranged on a pipeline between the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13, the first gas circuit branch point 9 is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit.
The oxygen generator also comprises an air resistor 14, a first on-off valve 15 and a bypass path, wherein the air storage tank 3, the air resistor 14, the first on-off valve 15 and the first air path branch point 9 are sequentially connected through pipelines to form the bypass path. The respiration monitoring unit is a differential pressure sensor 16.
And the gas storage tank 3 is provided with a tank internal pressure sensor 4.
The oxygen concentration pressure monitoring unit adopts an oxygen concentration sensor.
The first gas path branch point 9 is connected by a tee.
In this embodiment, an on-off valve may be further disposed on the pipeline between the pressure regulating valve 6 and the flow meter 7 to implement a corresponding gas path on-off function.
Compared with the embodiment 2, the embodiment adopts the differential pressure sensor to replace a respiration detection branch composed of the micro-flow detection sensor and the second on-off valve, adopts the differential pressure sensor to be connected in series on the bypass gas path to realize respiration monitoring, cannot detect the oxygen concentration value of the output gas in the pulse gas supply mode at the moment, can open the flowmeter on the main gas path intermittently in a short time, and enables a small amount of oxygen to detect the oxygen concentration through the oxygen concentration sensor on the main gas path.
The oxygen concentration sensor is adopted in the embodiment to detect the oxygen concentration and the oxygen flow during continuous ventilation, and whether the oxygen nozzle is blocked or not can be judged by detecting the flow.
Example 4
As shown in fig. 4, the dual-mode oxygen generator comprises an oxygen generation unit 1, a gas storage tank 3, a pressure regulating valve 6, a flow meter 7, a pressure sensor 17, an oxygen outlet nozzle 13 and a respiration monitoring unit;
the oxygen generation unit 1 is connected with a gas storage tank 3 through a pipeline provided with a one-way valve 2;
the gas storage tank 3, the pressure regulating valve 6, the flowmeter 7, the pressure sensor 17 and the oxygen outlet nozzle 13 are sequentially connected through the connecting pipeline 5 to form a main gas circuit, a first gas circuit branch point 9 is arranged on a pipeline between the pressure sensor 17 and the oxygen outlet nozzle 13, the first gas circuit branch point 9 is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit.
The oxygen generator also comprises an air resistor 14, a first on-off valve 15 and a bypass path, wherein the air storage tank 3, the air resistor 14, the first on-off valve 15 and the first air path branch point 9 are sequentially connected through pipelines to form the bypass path. The respiration monitoring unit includes a second shut-off valve 10 and a micro flow detection sensor 11 connected by a pipe.
And the gas storage tank 3 is provided with a tank internal pressure sensor 4.
The present embodiment employs the pressure sensor 17 as the oxygen concentration pressure monitoring unit.
The first gas path branch point 9 is connected by a tee.
In this embodiment, an on-off valve may be further disposed on the pipeline between the pressure regulating valve 6 and the flow meter 7 to implement a corresponding gas path on-off function.
In this embodiment, adopt pressure sensor to replace oxygen concentration sensor as oxygen concentration pressure monitoring unit, when lasting the oxygen suppliment mode, the second shut-off valve on the other gas circuit is opened to intermittent type nature, closes after flowing through a small amount of oxygen, detects oxygen concentration through micro flow detection sensor, and the flow is fixed through using mechanical type flowmeter manual regulation, judges through pressure sensor whether the oxygen nozzle is stifled the pipe.
Example 5
As shown in fig. 5, the dual-mode oxygen generator comprises an oxygen generation unit 1, a gas storage tank 3, a pressure regulating valve 6, a flow meter 7, an oxygen concentration pressure monitoring unit 12, an oxygen outlet nozzle 13 and a respiration monitoring unit;
the oxygen generation unit 1 is connected with a gas storage tank 3 through a pipeline provided with a one-way valve 2;
the gas storage tank 3, the pressure regulating valve 6, the flowmeter 7, the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13 are sequentially connected through the connecting pipeline 5 to form a main gas circuit, and a first gas circuit branch point 9 is arranged on a pipeline between the oxygen concentration pressure monitoring unit 12 and the oxygen outlet nozzle 13.
The oxygen generator also comprises an air resistor 14, a first on-off valve 15 and a bypass path, wherein the air storage tank 3, the air resistor 14, the first on-off valve 15 and the first air path branch point 9 are sequentially connected through pipelines to form the bypass path.
And the gas storage tank 3 is provided with a tank internal pressure sensor 4.
The oxygen concentration pressure monitoring unit adopts an integrated sensor with oxygen concentration, oxygen flow and breathing micro-flow detection functions.
The first gas path branch point 9 is connected by a tee.
A second gas path branch point is provided in the line between the oxygen concentration pressure monitoring unit 12 and the flow meter 7, and the second gas path branch point is connected to a third shut-off valve 18.
This embodiment is for retrenching the structure, improves the reliability, replaces the micro-flow detection sensor of oxygen concentration sensor on the main gas circuit and branch road into the sensor that integrates of detectable oxygen concentration, flow and breathing miniflow, integrates two gas circuits more. When in the continuous gas supply mode, the third on-off valve and the first on-off valve on the bypass gas path are closed, and the integrated sensor is used as an oxygen concentration sensor; when at pulse oxygen suppliment mode, the flowmeter on the main gas circuit is closed, and first break-make valve on the other gas circuit opens, integrates the sensor this moment and acts as microflow detection sensor and constitutes the respiration detection branch road with the third break-make valve, integrates sensor and third break-make valve and uses as respiration monitoring unit.
Example 6
As shown in fig. 6, based on the foregoing embodiments 1-5, the dual-mode oxygen generator and the oximeter 19 can be connected in parallel to use and match the constructed intelligent health control system, the oximeter is added to detect the blood oxygen saturation level of the user, when the blood oxygen concentration of the user 8 is still lower than 95% under the condition of long-term continuous oxygen supply, the oxygen generator automatically adjusts the oxygen supply mode to the pulse oxygen supply mode, so as to improve the therapeutic effect, when the blood oxygen saturation level of the user 8 is increased to more than 98%, the oxygen generator switches back to the continuous oxygen supply mode and prompts the blood oxygen saturation level of the user to return to normal by voice, thereby avoiding oxygen poisoning caused by long-term efficient oxygen generation.
Conventional technical knowledge in the art can be used for the details which are not described in the present invention.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and are not limited. Although the present invention has been described in detail with reference to the embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (9)
1. A dual-mode oxygen generator is characterized by comprising an oxygen generation unit, a gas storage tank, a pressure regulating valve, a flow meter, an oxygen concentration and pressure monitoring unit, an oxygen outlet nozzle and a respiration monitoring unit;
the oxygen generation unit is connected with the gas storage tank through a pipeline provided with a one-way valve;
the oxygen concentration monitoring device comprises an oxygen storage tank, a pressure regulating valve, a flowmeter, an oxygen concentration pressure monitoring unit and an oxygen outlet nozzle, wherein the gas storage tank, the pressure regulating valve, the flowmeter, the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle are sequentially connected through a pipeline to form a main gas circuit, a first gas circuit branch point is arranged on the pipeline between the oxygen concentration pressure monitoring unit and the oxygen outlet nozzle, the first gas circuit branch point is connected with a detection gas circuit, and a respiration monitoring unit is arranged on the detection gas circuit.
2. The dual-mode oxygen generator as claimed in claim 1, further comprising an air resistor, a first on-off valve and a bypass path, wherein the air storage tank, the air resistor, the first on-off valve and the first air path branch point are connected in sequence through a pipeline to form the bypass path.
3. The dual-mode oxygen generator as claimed in claim 2, wherein a second gas path branch point is provided on the pipeline between the oxygen concentration pressure monitoring unit and the flow meter, the second gas path branch point being connected to a third shut-off valve;
when the second gas circuit branch point is connected with the third cut-off valve, the first gas circuit branch point is not connected with the detection gas circuit.
4. The dual-mode oxygen generator as claimed in claim 1, wherein the respiration monitoring unit is a second shut-off valve and a micro-flow sensor, or a differential pressure sensor.
5. The dual-mode oxygen generator as claimed in claim 1, wherein the oxygen concentration pressure monitoring unit is an oxygen concentration sensor or an oxygen pressure sensor or an integrated sensor with oxygen concentration, oxygen flow and breathing micro flow detection functions.
6. The dual-mode oxygen generator as claimed in claim 1, wherein a tank pressure sensor is disposed on the gas storage tank.
7. An oxygen supply system, characterized in that the oxygen supply system comprises an oximeter and a dual-mode oxygen generator as claimed in any one of claims 1-6, wherein the dual-mode oxygen generator and the oximeter are connected in parallel to a control unit.
8. An oxygen supply method of a dual-mode oxygen generator comprises the following steps:
1) the oxygen generation unit continuously generates oxygen and conveys the generated oxygen to the gas storage tank for storage; providing a continuous oxygen supply mode or a pulse oxygen supply mode according to the needs of a user;
2) continuous oxygen supply mode:
closing the detection gas circuit and the respiration monitoring unit;
the air storage tank outputs a stable pressure constant flow air flow through a pressure regulating valve and a flowmeter, the stable pressure constant flow air flow is output to an oxygen concentration pressure monitoring unit, the oxygen concentration pressure monitoring unit detects the oxygen concentration and flow value of the constant flow air flow, and finally the detected oxygen flow is continuously supplied to a user through an oxygen outlet nozzle;
pulse oxygen supply mode:
when the pulse mode is switched, the detection gas circuit and the respiration monitoring unit are normally opened, and the flowmeter is firstly closed;
when the user breathes in, the air gets into from breathing monitoring unit's gas outlet, flow to the oxygen mouth through breathing monitoring unit back flow direction, it detects the flow of small air current to breathe monitoring unit this moment, the flowmeter is opened, breathe monitoring unit and close after delaying the uniform time, the tolerance major part of the fixed volume of flowmeter rear end is carried the oxygen mouth through oxygen concentration pressure monitoring unit, the air of discharging behind the small part through breathing monitoring unit, breathe monitoring unit and detect the concentration of output oxygen through the small part oxygen air current that flows through, carry the back flowmeter that finishes and close, breathe monitoring unit and open, get into next breathing cycle.
9. An oxygen supply method of a dual-mode oxygen generator comprises the following steps:
1) the oxygen generation unit continuously generates oxygen and conveys the generated oxygen to the gas storage tank for storage; providing a continuous oxygen supply mode or a pulse oxygen supply mode according to the needs of a user;
2) continuous oxygen supply mode:
closing the detection gas circuit and the respiration monitoring unit; closing the first on-off valve;
the gas storage tank outputs a pressure-stabilizing constant-flow gas flow through a pressure regulating valve and a flowmeter, the pressure-stabilizing constant-flow gas flow is output to an oxygen concentration pressure monitoring unit after passing through a first on-off valve, the oxygen concentration pressure monitoring unit detects the oxygen concentration and flow value of the constant-flow gas flow, and finally the detected oxygen flow is continuously supplied to a user through an oxygen outlet nozzle;
pulse oxygen supply mode:
when the pulse mode is switched, the detection gas circuit and the respiration monitoring unit are normally opened, and the flowmeter is closed;
when the user breathes in, the air gets into from breathing monitoring unit's gas outlet, flow to the oxygen mouth after monitoring unit is breathed, the monitoring unit that breathes detects the flow of small air current this moment, first on-off valve is opened, breathe monitoring unit and close after delaying the definite time, most rethread air resistance of tolerance through first on-off valve back fixed volume carries out the oxygen mouth, the air of discharging behind the monitoring unit is breathed to the subtotal, breathe monitoring unit and detect the concentration of output oxygen through the flowing subtotal oxygen air current, carry and finish the back first on-off valve and close, breathe monitoring unit and open, get into next respiratory cycle.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111562400.8A CN114209950A (en) | 2021-12-20 | 2021-12-20 | Dual-mode oxygen generator and oxygen supply method thereof |
| PCT/CN2022/131998 WO2023116265A1 (en) | 2021-12-20 | 2022-11-15 | Dual-mode oxygen generator and oxygen supply method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111562400.8A CN114209950A (en) | 2021-12-20 | 2021-12-20 | Dual-mode oxygen generator and oxygen supply method thereof |
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| WO (1) | WO2023116265A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115784165A (en) * | 2022-12-01 | 2023-03-14 | 深圳来福士雾化医学有限公司 | Oxygen generation system and control method thereof |
| WO2023116265A1 (en) * | 2021-12-20 | 2023-06-29 | 北京谊安健康科技有限公司 | Dual-mode oxygen generator and oxygen supply method thereof |
| CN117122787A (en) * | 2023-08-31 | 2023-11-28 | 广州蓝仕威克医疗科技有限公司 | Stable and accurate mixed gas tidal volume generation control device and breathing machine |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117784863B (en) * | 2024-02-27 | 2024-05-17 | 中山清匠电器科技有限公司 | Environment detection and running state adjustment system for oxygenerator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205084144U (en) * | 2015-11-05 | 2016-03-16 | 康泰医学系统（秦皇岛）股份有限公司 | System for real -time supervision blood oxygen and intelligent automatic start turn -off system oxygen |
| CN112546388A (en) * | 2020-12-04 | 2021-03-26 | 可孚医疗科技股份有限公司 | Self-adaptive pulse type oxygen generator and oxygen supply control method and device thereof |
| CN214633307U (en) * | 2020-12-18 | 2021-11-09 | 长沙巨翊医疗科技有限公司 | Dual-mode oxygen supply system and oxygen generator |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002143306A (en) * | 2000-11-14 | 2002-05-21 | Gunma Koike:Kk | Respiration synchronization-type oxygen supplying device |
| JP4598357B2 (en) * | 2002-12-17 | 2010-12-15 | 帝人株式会社 | Oxygen supply equipment |
| CN108946672A (en) * | 2018-08-06 | 2018-12-07 | 佛山市欧斯德医疗器械科技有限公司 | A kind of Portable Oxygen generator and its control mode based on pulse mode |
| CN210595260U (en) * | 2019-05-28 | 2020-05-22 | 慨迩医疗科技(成都)有限公司 | Portable oxygen generator |
| CN111729165A (en) * | 2020-07-02 | 2020-10-02 | 杭州富士达特种材料股份有限公司 | Control device for oxygen supply system and oxygen supply method |
| CN111821552A (en) * | 2020-08-14 | 2020-10-27 | 华氧医疗科技(大连)有限公司 | Multifunctional respiratory therapy system and method for hospital and family environment |
| CN114209950A (en) * | 2021-12-20 | 2022-03-22 | 北京谊安健康科技有限公司 | Dual-mode oxygen generator and oxygen supply method thereof |
-
2021
- 2021-12-20 CN CN202111562400.8A patent/CN114209950A/en active Pending
-
2022
- 2022-11-15 WO PCT/CN2022/131998 patent/WO2023116265A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205084144U (en) * | 2015-11-05 | 2016-03-16 | 康泰医学系统（秦皇岛）股份有限公司 | System for real -time supervision blood oxygen and intelligent automatic start turn -off system oxygen |
| CN112546388A (en) * | 2020-12-04 | 2021-03-26 | 可孚医疗科技股份有限公司 | Self-adaptive pulse type oxygen generator and oxygen supply control method and device thereof |
| CN214633307U (en) * | 2020-12-18 | 2021-11-09 | 长沙巨翊医疗科技有限公司 | Dual-mode oxygen supply system and oxygen generator |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023116265A1 (en) * | 2021-12-20 | 2023-06-29 | 北京谊安健康科技有限公司 | Dual-mode oxygen generator and oxygen supply method thereof |
| CN115784165A (en) * | 2022-12-01 | 2023-03-14 | 深圳来福士雾化医学有限公司 | Oxygen generation system and control method thereof |
| CN117122787A (en) * | 2023-08-31 | 2023-11-28 | 广州蓝仕威克医疗科技有限公司 | Stable and accurate mixed gas tidal volume generation control device and breathing machine |
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| Publication number | Publication date |
|---|---|
| WO2023116265A1 (en) | 2023-06-29 |
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