CN114209314A - 一种可穿戴汗液多生理参数电化学检测装置 - Google Patents
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Abstract
本发明为一种可穿戴汗液多生理参数电化学检测装置，包括柔性基底模块、电化学传感阵列模块、汗液导流模块、电路采集模块、蓝牙传输模块及移动终端模块。电化学传感阵列模块和汗液导流模块依次安装在柔性基底模块上，其中汗液导流模块的汗液收集区置于柔性基底模块的汗液收集孔上方，用于与皮肤接触并收集汗液，而汗液导流模块的汗液集中区置于电化学传感阵列模块上方，用于汗液检测；电路采集模块将得到的电化学信号转换成数字信号，再经蓝牙传输模块发送给移动终端模块进行分析处理及结果输出。本发明可对人体汗液中多项生物健康指标进行实时持续检测，方便快捷，简单实用。
Description
一、技术领域
本发明涉及可穿戴电子器件领域，尤其是涉及一种可穿戴汗液多生理参数电化学检测系统及装置。
二、背景技术
近二十年来，随着材料、生物传感、加工工艺、通讯技术、电子信息等领域的发展，可穿戴电子器件在医疗保健领域得到飞速发展。可穿戴式传感设备因其便捷性、无创性、实时性等优点越来越受消费者的青睐。通过穿戴在身上，可穿戴传感器能连续实时检测人体的生理信息，而这些信息通过无线蓝牙装置与智能手机或电脑连接进而与整个互联网相连建立大数据库，有望实现个性化病情监控与治疗。目前，可穿戴传感器已实现心率、血压等检测，但总体上还处于发展初期，与生理相关的大部分参数的检测尚有待开发。
汗液中含有丰富的代谢产物、蛋白质、激素和电解质等生理物质，它们的浓度能反映人体生理状态或提供某些疾病相关的信息。例如，汗液氯化物测试能用于新生儿的囊性纤维化的诊断；汗液中钠离子和氯离子的损失是确定人体电解质是否失衡的重要指标；汗液中葡萄糖的浓度与血液中葡萄糖的浓度正相关，因此通过对汗液中葡萄糖浓度的监测可对糖尿病患者的病情进行监测；乳酸的浓度是体力消耗的指标，通过汗液乳酸的监测可获得压力缺血和组织缺氧信息；汗液pH值的增加可用于评判代谢性碱中毒等。另外，由于汗液样本易取、无创，开发汗液中生物健康指标实时检测的可穿戴式汗液传感器，具有非常大的市场前景，对个性化预防医疗保健体系的建立也具有积极意义。
本发明通过设计新型柔性电化学传感阵列和汗液导流模式，集成电路采集、蓝牙传输和移动终端数据处理及分析模块，提出一种可穿戴电化学检测装置，用于人体汗液中多项生物健康指标的实时持续检测，具有方便快捷、简单实用等特点。
三、发明内容
本发明的目的是提出一种可穿戴汗液多生理参数电化学检测装置，实现汗液中葡萄糖、乳酸、H+、Na+、K+等多生理健康指标的实时持续检测。
本发明通过以下技术方案来实现：
一种可穿戴汗液多生理参数电化学检测装置，包括柔性基底模块、电化学传感阵列模块、汗液导流模块、电路采集模块、蓝牙传输模块及移动终端模块(图1)：电化学传感阵列模块和汗液导流模块依次安装在柔性基底模块上，电路采集模块、蓝牙传输模块及移动终端模块与电化学传感阵列模块依次相连；汗液导流模块通过柔性基底模块上的汗液收集孔与皮肤接触并收集汗液，收集的汗液在置于汗液导流模块下方的电化学传感阵列模块上进行检测，之后被新收集的汗液排挤出汗液导流模块，而电化学传感阵列模块会对新收集的汗液进行检测，汗液检测及排挤过程重复进行，实现汗液的持续检测；电化学传感阵列模块检测汗液所得到的电化学信号会被电路采集模块实时地转换成数字信号，并通过蓝牙传输模块发送给移动终端模块进行分析处理及检测结果输出。
上述的柔性基底模块由亲肤的双面粘性材料制备，带有数量多、分布广的汗液收集孔，一面与皮肤贴合，另一面固定电化学传感阵列模块和汗液导流模块。
上述的汗液导流模块包括汗液收集区、汗液集中区和汗液排出口，其中汗液收集区置于柔性基底模块的汗液收集孔上方，用于与皮肤接触并收集汗液，而汗液集中区置于电化学传感阵列上方，为检测装置提供汗液样品。电化学传感阵列模块由柔性电极阵列制备，可同时进行多通道电位传感与安培检测。
上述的电化学传感阵列主要包括一个、两个或者多个离子选择性电极与生物传感电极，如Na+、K+、H+、Ca2+、Cl-等离子选择性电极，和乳酸氧化酶、乳酸脱氢酶、葡萄糖氧化酶、葡萄糖脱氢酶、乙醇氧化酶、尿酸氧化酶等生物酶电极。
上述的电路采集模块与电化学传感阵列模块匹配，进行多通道电位与电流信号的收集。
上述的移动终端模块包括移动终端设备和操作软件。移动终端设备是可以接受蓝牙信号的智能机器，例如手机、电脑等；操作软件是用户友好型app；app可以通过蓝牙与所述的电路采集模块连接，实时监控可穿戴汗液多生理参数。
本发明提供的检测装置，可穿戴在胳膊(图2)、额头等人体易出汗部位对汗液中的Na+、K+、H+、葡萄糖、乳酸等多生理参数进行持续监测(图3)。
本发明与现有技术相比，具有以下优点：
(1)本发明提出的可穿戴汗液多生理参数电化学检测装置由柔性基底、电化学传感阵列、汗液导流、电路采集、蓝牙传输及移动终端6个模块集成制备，每个模块可独立生成，工艺简单、成本低廉。
(2)本发明提出的可穿戴汗液多生理参数电化学检测装置既能独立使用，也能灵活地组装在服装或手环等可穿戴配件上，对身体各个部位的汗液进行实时连续检测，操作简单，携带方便。
(3)本发明提出的可穿戴汗液多生理参数电化学检测装置，能紧贴皮肤，对汗液中的K+、Na+、H+、葡萄糖和乳酸等多生理参数进行同时持续检测，并通过蓝牙和移动终端实时获取其浓度及其变化情况，从而对人体健康状态进行实时监测、分析或预警。
四、附图说明
图1.本发明提供的可穿戴汗液多生理参数电化学检测装置的结构示意图；
图2.本发明提供的可穿戴汗液多生理参数电化学检测装置的穿戴示意图；
图3.本发明提供的可穿戴汗液多生理参数电化学检测装置的移动终端显示结果的示意图。
五、具体实施方式
为使本发明的目的、技术方案及优点更加清晰，以下结合附图及实施例，对本发明进一步详细说明。应当理解，此处所描述的具体实例为本发明的首选，仅仅用以解释本发明，并不用于限定本发明。
结合附图1和图2说明，所发明的可穿戴汗液多生理参数电化学检测装置穿戴在手臂上对汗液中K+、Na+、H+、葡萄糖和乳酸5种生理指标进行同时持续检测。
所发明的可穿戴汗液多生理参数电化学检测装置由柔性基底、电化学传感阵列、汗液导流、电路采集、蓝牙传输及移动终端6个模块依次相连组建而成，并通过柔性基底穿戴在人体出汗部位，譬如手臂上。皮肤汗液经柔性基底模块上的汗液收集孔被汗液导流模块的汗液收集区收集并导流至汗液导流模块的汗液集中区，置于汗液集中区下方的电化学传感阵列对汗液进行检测，之后皮肤上新产生的汗液通过上述路径到达汗液集中区，而汗液集中区的初始汗液会通过汗液排出口被吸汗织物吸走，同时电化学传感阵列对汗液集中区的新汗液进行检测，如此重复，随着汗液的持续生成完成汗液的持续检测。电化学传感阵列模块检测汗液所得到的电化学信号会被电路采集模块实时地转换成数字信号，并通过蓝牙传输模块发送给移动终端模块进行分析处理及检测结果输出。
本实施例中，电化学传感阵列模块由八通道柔性电极阵列制备，包括1个Au对电极、2个Ag/AgCl参比电极、1个Na+选择性电极、1个K+选择性电极、1个H+选择性电极(pH电极)、1个葡萄糖氧化酶修饰电极和1个乳酸脱氢酶修饰电极。
Na+、K+、H+选择性电极通过共用1个Ag/AgCl参比电极，构成3组两电极电位检测体系，分别用于汗液中Na+、K+、H+的检测。
葡萄糖氧化酶修饰电极和乳酸脱氢酶修饰电极通过共用1个Ag/AgCl参比电极和1个对电极，构成2组三电极安培检测体系，分别用于汗液中葡萄糖和乳酸的检测。
本实施例中，移动终端模块由智能手机和手机app检测小程序组成。手机app检测小程序通过蓝牙连接电路采集模块，能控制电化学传感阵列模块对汗液的检测，也能接收汗液检测的数字信号，并进行分析处理及转化为可视化数据输出(图3)，用户可以通过读取移动终端上的检测结果来了解自身的身体健康情况，并做好早期预防和管理。
以上所述的装置实施例仅仅是示意性的，所述模块的划分为一种逻辑功能划分，在实施时可以有另外的划分方式。例如，多个模块元或组件可以结合或者可以集成到另一个系统，或可以忽略一些特征。另外，所显示的相互间耦合或通信连接可以通过一些接口、装置或单元来执行。
Claims (5)
1.一种可穿戴汗液多生理参数电化学检测装置，其特征在于它包括柔性基底模块、电化学传感阵列模块、汗液导流模块、电路采集模块、蓝牙传输模块及移动终端模块；电化学传感阵列模块和汗液导流模块依次安装在柔性基底模块上，汗液经柔性基底模块上的汗液收集孔被汗液导流模块收集，再被置于汗液导流模块下方的电化学传感阵列模块检测，所得到的电化学信号被电路采集模块转换成数字信号，并通过蓝牙传输模块发送给移动终端模块进行分析处理及汗液检测结果输出。
2.根据权利要求1所述的检测装置，其特征在于，所述的柔性基底模块上有数量多、分布广的汗液收集孔，可与皮肤贴合，而另一面固定电化学传感阵列模块和汗液导流模块。
3.根据权利要求1所述的检测装置，其特征在于，所述的汗液导流模块包括汗液收集区、汗液集中区和汗液排出口，其中汗液收集区置于柔性基底模块的汗液收集孔上方，与皮肤接触并收集汗液，而汗液集中区置于电化学传感阵列上方，为汗液检测提供样品。
4.根据权利要求1所述的检测装置，其特征在于，所述的电化学传感阵列模块由柔性电极阵列制备，可同时对Na+、K+、H+、Ca2+、Cl-、葡萄糖、乳酸、尿酸等生理参数进行电位或安培检测。
5.根据权利要求1所述的检测装置，其特征在于，所述的电路采集模块与电化学传感阵列模块相连，收集多通道电位与电流信号，并通过蓝牙传输模块发送给移动终端模块进行分析处理及检测结果输出。
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