CN114206913A - 新的癌抗原和方法 - Google Patents

新的癌抗原和方法 Download PDF

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Publication number
CN114206913A
CN114206913A CN202080049314.4A CN202080049314A CN114206913A CN 114206913 A CN114206913 A CN 114206913A CN 202080049314 A CN202080049314 A CN 202080049314A CN 114206913 A CN114206913 A CN 114206913A
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polypeptide
cells
seq
cancer
sequence
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CN202080049314.4A
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Chinese (zh)
Inventor
G·卡西奥蒂斯
G·扬
J·阿蒂格
F·马里诺
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Enara Biology Ltd
Francis Crick Institute Ltd
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Enara Biology Ltd
Francis Crick Institute Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4201—Neoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A61K2039/876—Skin, melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2740/00—Reverse transcribing RNA viruses
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CN202080049314.4A 2019-07-05 2020-07-03 新的癌抗原和方法 Pending CN114206913A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19184680 2019-07-05
EP19184680.7 2019-07-05
EP20170224.8 2020-04-17
EP20170224 2020-04-17
PCT/GB2020/051592 WO2021005338A2 (en) 2019-07-05 2020-07-03 Novel cancer antigens and methods

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CN114206913A true CN114206913A (zh) 2022-03-18

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CN202080049314.4A Pending CN114206913A (zh) 2019-07-05 2020-07-03 新的癌抗原和方法

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US (1) US20220213159A1 (enExample)
EP (1) EP3993826A2 (enExample)
JP (2) JP7751817B2 (enExample)
KR (1) KR20220034040A (enExample)
CN (1) CN114206913A (enExample)
AU (1) AU2020309202A1 (enExample)
BR (1) BR112022000020A2 (enExample)
CA (1) CA3142329A1 (enExample)
IL (1) IL289335A (enExample)
MX (1) MX2022000263A (enExample)
WO (1) WO2021005338A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7712207B2 (ja) 2018-10-19 2025-07-23 ザ フランシス クリック インスティチュート リミティッド 新規な癌抗原及び方法
CN116057067A (zh) * 2020-04-17 2023-05-02 弗朗西斯·克里克研究所有限公司 用于治疗黑素瘤的ctl抗原的融合蛋白
JP2023522193A (ja) * 2020-04-17 2023-05-29 ザ フランシス クリック インスティチュート リミティッド 抗原プール
WO2025202937A1 (en) 2024-03-26 2025-10-02 BioNTech SE Cancer vaccines

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2005099750A1 (en) * 2004-04-16 2005-10-27 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Vaccination against malignant melanoma using bcg and/or vaccinia
WO2006105642A1 (en) * 2005-04-05 2006-10-12 British Columbia Cancer Agency Biomarkers for the detection of lung cancer and uses thereof
WO2006119527A2 (en) * 2005-05-11 2006-11-16 Avir Green Hills Biotechnology Research Development Trade Ag Melanoma-associated endogenous retrovirus (merv) derived peptide sequences and their therapeutic/ diagnostic use
CA2685049A1 (en) * 2007-05-24 2008-11-27 Avir Green Hills Biotechnology Research Development Trade Ag Antibodies useful for therapy and diagnosis of cancer
CN104204222A (zh) * 2011-08-30 2014-12-10 Dcb-美国有限责任公司 预测易罹患卵巢赘瘤或卵巢癌预后的生物标记

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EP0871747A1 (en) 1996-01-02 1998-10-21 Chiron Viagene, Inc. Immunostimulation mediated by gene-modified dendritic cells
US6770456B1 (en) 1998-07-29 2004-08-03 Ludwig Institute For Cancer Research Endogenous retrovirus tumor associated nucleic acids and antigens
WO2006103562A2 (en) 2005-03-30 2006-10-05 Centre National De La Recherche Scientifique (Cnrs) Endogenous retrovirus and proteins encoded by env gene as a target for cancer treatment
WO2007109583A2 (en) 2006-03-17 2007-09-27 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject
EP2032162A2 (en) 2006-05-22 2009-03-11 Board of Regents, The University of Texas System Herv-k antigens, antibodies, and methods
US10723782B2 (en) * 2017-12-28 2020-07-28 Codiak Biosciences, Inc. Exosomes for immuno-oncology and anti-inflammatory therapy
CN116057067A (zh) * 2020-04-17 2023-05-02 弗朗西斯·克里克研究所有限公司 用于治疗黑素瘤的ctl抗原的融合蛋白

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005099750A1 (en) * 2004-04-16 2005-10-27 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Vaccination against malignant melanoma using bcg and/or vaccinia
WO2006105642A1 (en) * 2005-04-05 2006-10-12 British Columbia Cancer Agency Biomarkers for the detection of lung cancer and uses thereof
WO2006119527A2 (en) * 2005-05-11 2006-11-16 Avir Green Hills Biotechnology Research Development Trade Ag Melanoma-associated endogenous retrovirus (merv) derived peptide sequences and their therapeutic/ diagnostic use
CA2685049A1 (en) * 2007-05-24 2008-11-27 Avir Green Hills Biotechnology Research Development Trade Ag Antibodies useful for therapy and diagnosis of cancer
CN104204222A (zh) * 2011-08-30 2014-12-10 Dcb-美国有限责任公司 预测易罹患卵巢赘瘤或卵巢癌预后的生物标记

Non-Patent Citations (1)

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Title
P.F.FERRUCCI 等: "Newly Identified Tumor Antigens as Promising Cancer Vaccine Targets for Malignant Melanoma Treatment", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 12, no. 1, pages 11 - 31, XP055652022, DOI: 10.2174/156802612798919213 *

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WO2021005338A3 (en) 2021-02-18
JP2025124655A (ja) 2025-08-26
US20220213159A1 (en) 2022-07-07
JP7751817B2 (ja) 2025-10-09
AU2020309202A1 (en) 2021-12-09
WO2021005338A2 (en) 2021-01-14
JP2022540396A (ja) 2022-09-15
KR20220034040A (ko) 2022-03-17
MX2022000263A (es) 2022-02-03
EP3993826A2 (en) 2022-05-11
BR112022000020A2 (pt) 2022-05-24
IL289335A (en) 2022-02-01
CA3142329A1 (en) 2021-01-14

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