CN114190934A - Sensor for monitoring multiple human body physiological indexes - Google Patents
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- 238000012544 monitoring process Methods 0.000 title claims abstract description 21
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 22
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 22
- 239000008280 blood Substances 0.000 claims abstract description 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 18
- 210000004369 blood Anatomy 0.000 claims abstract description 18
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 18
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- 229910000530 Gallium indium arsenide Inorganic materials 0.000 claims abstract description 10
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 10
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- 108010061951 Methemoglobin Proteins 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 4
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- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
Abstract
The invention relates to the technical field of sensors and discloses a sensor for monitoring multiple human body physiological indexes, which comprises a controller, a transmitter and a receiver, wherein a plurality of transmitting chips for transmitting light waves with different wavelengths are fixedly crystallized on a transmitting bracket of the transmitter, and the wavelengths of the light waves transmitted by the plurality of transmitting chips are respectively equal to HbO2The four hemoglobin of Hb, MetHb and COHb correspond to absorption spectra of different wavelengths; two receiving chips, namely a silicon-based chip and a ternary InGaAs-based chip, are fixedly crystallized on a receiving bracket of the receiver, a plurality of transmitting chips transmit light waves with different wavelengths to pass through fingers and then are received by the two receiving chips to form light wave data, and a controller calculates the blood oxygen saturation concentration value according to the light wave data; this takes into account the presence of the hemoglobin components, resulting in a measured SpO2The numerical value is more accurate, and a plurality of human physiological indexes such as SpHb, SpMet, SpCO, PI, PVI and the like can be continuously detected.
Description
Technical Field
The invention relates to the technical field of sensors, in particular to a sensor for monitoring multiple human body physiological indexes.
Background
With the development of science and technology and the improvement of living standard, people pay more and more attention to their health. The physiological parameters such as blood oxygen saturation concentration, heart rate, hemoglobin concentration and the like not only have wide clinical diagnosis significance, but also are reference standards for monitoring the health condition of people. The hemoglobin content is an important index for evaluating the anemia and iron nutrition status of an individual, and the existing detection method needs to take blood for a patient, so that the material cost is high, the blood taking can bring pain to the patient, and the continuous monitoring cannot be realized.
Currently, the principle of optical PPG is used to measure the blood oxygen saturation concentration (SpO)2) Considering only the presence of oxyoxymetanin (HbO) in hemoglobin in blood2) And deoxyhemoglobin (Hb), and the influence of methemoglobin (MetHb) and carboxyhemoglobin (COHb) losing oxygen-carrying function on absorbance is not considered, so that the obtained SpO2The measurement is not very accurate.
Therefore, it is necessary to find a composition containing HbO2The SpO can be accurately measured even in the case of hemoglobin of four components of Hb, MetHb and COHb2And physiological indexes such as SpHb, SpMet, SpCO, PI, and PVI.
Disclosure of Invention
The invention aims to provide a sensor for monitoring multiple human body physiological indexes, and aims to solve the problem that the sensor is not accurate enough in measuring the blood oxygen saturation concentration in the prior art.
The sensor for monitoring multiple human body physiological indexes comprises a control board, a transmitter and a receiver, wherein the transmitter comprises an integrally formed transmitting bracket, a plurality of transmitting chips for transmitting light waves with different wavelengths are fixedly crystallized on the transmitting bracket, and the wavelengths of the light waves transmitted by the plurality of transmitting chips respectively correspond to absorption spectrums of four hemoglobin, namely HbO2, Hb, MetHb and COHb, of different wavelengths; the receiver comprises a receiving support, two receiving chips are fixedly crystallized on the receiving support, the two receiving chips are respectively a silicon-based chip and a ternary InGaAs-based chip, a plurality of transmitting chips transmit light waves with different wavelengths to penetrate through fingers and then are received by the two receiving chips to form light wave data, and the controller calculates the blood oxygen saturation concentration value according to the light wave data.
Further, the emission chip comprises a visible light chip, and the wavelength range of the light waves emitted by the visible light chip is 620 nm-780 nm.
Further, the emission chip comprises a near-infrared chip, and the wavelength range of the light wave emitted by the near-infrared chip is 780 nm-2000 nm.
Furthermore, the emission support is provided with an emission area, a circuit board is printed on the emission area, the emission chip is arranged on the emission area, an emission transparent adhesive layer covers the emission area, and the emission transparent adhesive layer covers the emission chip.
Furthermore, the emission area comprises a plurality of functional areas which are arranged in sequence, each functional area is provided with two emission chips, and adjacent functional areas have a common connecting pin position.
Further, the emitting area is provided with a thermistor, which monitors the temperature of the emitting area.
Further, the periphery of the emission area is provided with an emission frame for isolating light waves, and the emission frame is arranged around the periphery of the emission area.
Furthermore, the wavelength range of the light wave received by the silicon-based chip is 380 nm-1000 nm.
Furthermore, the wavelength range of the light wave received by the ternary InGaAs-based chip is between 1000nm and 2000 nm.
Furthermore, the outer parts of the transmitter and the receiver are wrapped with soft rubber pads, the two soft rubber pads are connected into a whole through an external component, mounting structures are arranged on the two soft rubber pads and the external component, and each mounting structure comprises an insertion groove formed in the external component and clamping parts formed in the two soft rubber pads; the insertion groove is provided with two inner side walls, the tops of the two inner side walls protrude inwards to form limiting strips, the limiting strips extend along the axial direction of the insertion groove, and the depth of the insertion groove is gradually reduced along the direction from inside to outside of the external component; the soft rubber cushion is provided with an inner end face which is abutted against the external component, the middle part of the inner end face is convexly provided with the clamping part, the height of the clamping part is gradually increased along the direction from outside to inside of the soft rubber cushion, the clamping part is pushed into the insertion groove from outside to inside, and the soft rubber cushion is buckled and connected with the external component.
Compared with the prior art, the sensor for monitoring multiple human body physiological indexes provided by the invention has the advantages that the plurality of emission chips are fixedly crystallized on the emission support, and the wavelengths of light waves emitted by the plurality of emission chips are respectively equal to the HbO2The four hemoglobin such as Hb, MetHb and COHb correspond to absorption spectra of different wavelengths, and the two receiving chips are fixedly crystallized on the receiving bracket to absorb light waves passing through fingers, so that the existence of each component of the hemoglobin is fully considered, and the measured SpO2The numerical value is more accurate, and the method has the functions of high efficiency, low cost, no wound and continuous detection of multiple human physiological indexes such as SpHb, SpMet, SpCO, PI, PVI and the like.
Drawings
FIG. 1 is a schematic structural diagram of a sensor for monitoring multiple physiological indexes of a human body, which is provided by the invention, sleeved on a finger;
FIG. 2 is a graph of the absorption coefficients of four haemoglobins provided by the present invention for different wavelengths;
FIG. 3 is a flow chart of the controller data processing provided by the present invention;
FIG. 4 is a schematic top view of an emitter area of an emitter provided by the present invention;
FIG. 5 is a top view of the integrated stacked silicon-based chip and InGaAs-based chip for receiver receiving area provided by the present invention;
FIG. 6 is a schematic top view of a silicon-based chip and an InGaAs-based chip according to the present invention in parallel;
FIG. 7 is a schematic view of a structure of the soft rubber pad and an external member provided by the present invention;
FIG. 8 is a perspective view of a slot on an external member according to the present invention;
fig. 9 is a sectional structure diagram of the insertion groove and the clamping part provided by the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The following describes the implementation of the present invention in detail with reference to specific embodiments.
The same or similar reference numerals in the drawings of the present embodiment correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", etc. based on the orientation or positional relationship shown in the drawings, it is only for convenience of describing the present invention and simplifying the description, but it is not intended to indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limiting the present patent, and the specific meaning of the terms may be understood by those skilled in the art according to specific circumstances.
Referring to fig. 1-9, preferred embodiments of the present invention are provided.
The sensor for monitoring multiple human body physiological indexes comprises a controller, a transmitter 100 and a receiver 200, wherein the transmitter 100 comprises an integrally formed transmitting bracket, a plurality of transmitting chips 101 for transmitting light waves with different wavelengths are fixedly crystallized on the transmitting bracket, and the wavelengths of the light waves transmitted by the plurality of transmitting chips 101 and HbO (HbO) are respectively2The four hemoglobin of Hb, MetHb and COHb correspond to absorption spectra of different wavelengths; the receiver 200 includes a receiving support 201, two receiving chips 202 are die-bonded on the receiving support 201, the two receiving chips 202 are respectively a silicon-based chip and a ternary InGaAs-based chip, the plurality of emitting chips 101 emit light waves with different wavelengths to pass through the finger 300 and then are received by the two receiving chips 202 to form light wave data, and the controller calculates the blood oxygen saturation concentration according to the light wave data.
Meanwhile, the numerical values of human physiological indexes such as SpHb, SpMet, SpCO, PI, PVI and the like can be monitored.
Thus, by die-bonding the plurality of emitter chips 101 on the emitter support, the wavelengths of light waves emitted from the plurality of emitter chips 101 and HbO are respectively set to2Absorption spectrum pairs of four haemoglobins of Hb, MetHb and COHb on different wavelengthsThe two receiving chips 202 are simultaneously bonded on the receiving support 201 to absorb the light wave passing through the finger 300, and the existence of each hemoglobin component is fully considered, so that the measured SpO2The numerical value is more accurate, and the method has the functions of high efficiency, low cost, no wound and continuous detection of multiple human physiological indexes such as SpHb, SpMet, SpCO, PI, PVI and the like.
Wherein SpO2Refers to the blood oxygen saturation concentration, which is the percentage of the volume of oxygenated hemoglobin bound by oxygen in the blood to the total bindable hemoglobin (Hb) volume, i.e., the concentration of blood oxygen in the blood, which is an important physiological parameter of the respiratory cycle.
HbO2After hemoglobin is combined with oxygen, the hemoglobin is called oxyhemoglobin.
Hb refers to hemoglobin, a protein responsible for oxygen transport in higher organisms that gives blood a red color. Where the oxygen content is high, it is easily combined with oxygen, and where the oxygen content is low, it is easily separated from oxygen, and this characteristic of hemoglobin makes erythrocytes have a function of transporting oxygen.
MetHb refers to methemoglobin, where ferrous iron in the hemoglobin molecule prosthetic heme is oxidized to ferric iron, i.e., methemoglobin, while losing the oxygenated function.
COHb refers to carboxyhemoglobin, and CO is a common suffocating chemical poison seriously harming human health, and is mainly shown in that the CO is combined with hemoglobin (Hb) in blood to form carboxyhemoglobin (COHb), so that the Hb loses oxygen transfer capacity.
The absorption coefficients of the four haemoglobins for different wavelengths are shown in figure 2.
After the controller receives the lightwave data transmitted from the receiver 200, the data processing flow is shown in fig. 3.
According to lambert-Beer's law, I ═ I0*e-εcdWherein I is the intensity of emergent light, I0The incident light intensity is shown as epsilon, the absorption coefficient of the solution to the monochromatic light is shown as c, the concentration of the solution is shown as c, and the thickness of the solution is shown as d. When the relevant physiological index is measured through the finger 300 using the PPG technique, because of the skin, muscle and calm of the human bodyThe absorption of light by tissues such as pulse blood can be regarded as constant, and the change of the light absorption is caused by the change of vasodilation blood volume caused by heart compression. Assuming that the blood optical path length is increased by Δ d, the corresponding transmitted light intensity is represented by IDCBecome IDC-IACThe following equation can be obtained:
IDC-IAC＝IDC*e-(εHbO2*cHbO2+εHb*cHb+εCOHb*cCOHb+εMetHb*cMetHb)Δd (1)
taking logarithm of the deformation of formula (1) to obtain:
Ln[1-IAC/IDC]＝-(εHbo2.cHbO+εHb.cHb+εCOHb.cCOHb+εMetHb.cMetHb)Δd (2)
because the percentage of the alternating current component in the transmitted light to the direct current component is small and negligible, the following:
Ln[1-IAC/IDC]≈IAC/IDCand (2) can be changed into:
because Δ d is unknown in the formula, multiple wavelengths are used, the wavelengths are respectively set to be λ 1, λ 2, λ 3, λ 4 …,
by analogy, four groups or more than four groups of PI ratios are obtained by adopting a two-wavelength method, wherein the PI values can be obtained by adopting a PPG method, the absorption coefficients of all the wavelengths under the four hemoglobin are constants, and the PI values can be obtained by adopting a time domain or frequency domain spectral analysis method. From this can respectively be obtained cHbO2，cHb，cCOHb，cMetHb, i.e., the four hemoglobin concentration values. On the basis, accurate SpO can be obtained2Numerical values:
preferably, the emitting chip 101 includes a visible light chip, and the wavelength range of the light wave emitted by the visible light chip is 620nm to 780 nm.
Preferably, the emission chip 101 includes a near infrared light chip, and the wavelength range of the light wave emitted by the near infrared light chip is 780nm to 2000 nm.
The emission support is provided with an emission area, a circuit board is printed on the emission area, the emission chip 101 is arranged on the emission area, an emission transparent adhesive layer covers the emission area, and the emission transparent adhesive layer covers the emission chip 101; the transmitting chip 101 is coated by the transmitting transparent adhesive layer, so that the chip is protected, the service life of the sensor is prolonged, meanwhile, the interference of light rays of the surrounding environment to the sensor can be prevented, and the accuracy of data is ensured.
The emission region includes a plurality of functional regions 102 arranged in sequence, each functional region 102 is provided with two emission chips 101, and adjacent functional regions 102 have a common connection pin to realize a cross-region function.
The thermistor 103 is arranged in the transmitting area, and the thermistor 103 monitors the temperature of the transmitting area, so that the heat management function of the transmitter 100 is realized, and the discomfort caused by the overhigh temperature of the sensor to the finger 300 is prevented.
The periphery of the emission area is provided with an emission frame 104 for isolating light waves, and the emission frame 104 is arranged around the periphery of the emission area, so that the interference of light rays of the surrounding environment to the sensor can be prevented, and the accuracy of data is ensured.
Preferably, the wavelength range of the light wave received by the silicon-based chip is 380 nm-1000 nm, so that the light wave passing through the finger 300 is sufficiently absorbed by the receiver 200, and the accuracy of the light wave data is ensured.
Preferably, the wavelength range of the light wave received by the ternary InGaAs-based chip is between 1000nm and 2000nm, so that the light wave passing through the finger 300 is sufficiently absorbed by the receiver 200, and the accuracy of the light wave data is ensured.
The transmitter 100 and the receiver 200 are externally wrapped with soft rubber pads 400, the two soft rubber pads 400 are connected into a whole through an external member 500, the two soft rubber pads 400 and the external member 500 are provided with mounting structures, and the mounting structures comprise insertion grooves constructed on the external member 500 and clamping parts 401 constructed on the two soft rubber pads 400; the insertion groove is provided with two inner side walls, the tops of the two inner side walls protrude inwards to form limiting strips 5011, the limiting strips 5011 extend along the axial direction of the insertion groove 501, and the depth of the insertion groove is gradually reduced along the direction from inside to outside of the external component 500; soft cushion 400 has the interior terminal surface with external component 500 butt, and the middle part of interior terminal surface is protruding to be equipped with joint portion 401, along soft cushion 400 direction from the outside to the inside, joint portion 401 highly crescent is with joint portion 401 from the outside to the inside propulsion cartridge groove, and soft cushion 400 links together with external component 500 buckle.
In this way, through the mutually-matched structure of the insertion groove 501 and the clamping portion 401, the soft rubber pad 400 provided with the transmitter 100 and the receiver 200 can be conveniently installed on the external construction, and the soft rubber pad is convenient to disassemble and assemble if the transmitter or the receiver needs to be replaced or maintained.
The outer member 500 is provided with a hinge 502, and the opening angle of the outer member 500 can be controlled by the hinge 502.
The two soft rubber pads 400 have outer end portions abutted against the fingers, and the two outer end portions are arc-shaped with two high sides and a low middle part; place the finger on soft rubber pad 400, two circular-arc outer tip can be fixed with finger parcel all around, prevent that the finger from shifting to lead to measured data inaccurate.
The receiving bracket 201 is provided with a receiving area, a circuit board is printed on the receiving area, the receiving chip 202 is arranged on the receiving area, a receiving transparent adhesive layer covers the receiving area, and the receiving transparent adhesive layer covers the receiving chip 202; the receiving chip 202 is coated by the receiving transparent adhesive layer, so that the chip is protected, the service life of the sensor is prolonged, meanwhile, the interference of light rays of the surrounding environment to the sensor can be prevented, and the accuracy of data is ensured.
The silicon-based chip and the ternary InGaAs-based chip are arranged in a receiving area in an up-and-down stacking manner; the periphery of the receiving area is provided with a receiving frame 203 for isolating light waves, and the receiving frame 203 is arranged around the periphery of the receiving area; therefore, the interference of ambient light to the sensor can be prevented, and the accuracy of data is ensured.
The transmitting chip 101 is electrically connected to the transmitting support through a gold wire, and the receiving chip 202 is electrically connected to the receiving support through a gold wire.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. The sensor for monitoring multiple human body physiological indexes is characterized by comprising a control panel, a transmitter and a receiver, wherein the transmitter comprises an integrally formed transmitting bracket, a plurality of transmitting chips for transmitting light waves with different wavelengths are fixedly crystallized on the transmitting bracket, and the wavelengths of the light waves transmitted by the plurality of transmitting chips and HbO (HbO) are respectively2The four hemoglobin of Hb, MetHb and COHb correspond to absorption spectra of different wavelengths; the receiver comprises a receiving support, two receiving chips are fixedly crystallized on the receiving support, the two receiving chips are respectively a silicon-based chip and a ternary InGaAs-based chip, a plurality of transmitting chips transmit light waves with different wavelengths to penetrate through fingers and then are received by the two receiving chips to form light wave data, and the controller calculates the blood oxygen saturation concentration value according to the light wave data.
2. The sensor for monitoring multiple human physiological indexes according to claim 1, wherein the emission chip comprises a visible light chip, and the wavelength range of the light wave emitted by the visible light chip is 620 nm-780 nm.
3. The sensor for monitoring multiple human physiological indexes according to claim 1 or 2, wherein the emission chip comprises a near infrared light chip, and the wavelength range of light waves emitted by the near infrared light chip is 780 nm-2000 nm.
4. The sensor for monitoring multiple human physiological indexes as claimed in claim 1 or 2, wherein the emission support has an emission area, a circuit board is printed on the emission area, the emission chip is arranged on the emission area, an emission transparent adhesive layer covers the emission area, and the emission transparent adhesive layer covers the emission chip.
5. The sensor for monitoring multiple human physiological indexes according to claim 4, wherein the emitting area comprises a plurality of functional areas arranged in sequence, each functional area is provided with two emitting chips, and adjacent functional areas have a common connecting pin position.
6. The sensor for monitoring multiple human physiological indicators of claim 4, wherein the emitting area is provided with a thermistor, and the thermistor monitors the temperature of the emitting area.
7. The sensor for monitoring multiple human physiological indexes according to claim 4, wherein the emitting frame is arranged around the emitting area and is used for isolating light waves.
8. The sensor for monitoring multiple human physiological indexes as claimed in claim 1 or 2, wherein the wavelength range of the light wave received by the silicon-based chip is 380 nm-1000 nm.
9. The sensor for monitoring multiple human physiological indexes according to claim 8, wherein the wavelength range of the light waves received by the ternary InGaAs-based chip is between 1000nm and 2000 nm.
10. The sensor for monitoring multiple human body physiological indexes according to claim 1 or 2, wherein the transmitter and the receiver are externally wrapped with soft rubber pads, the two soft rubber pads are connected into a whole through an external component, and mounting structures are arranged on the two soft rubber pads and the external component and comprise insertion grooves constructed on the external component and clamping parts constructed on the two soft rubber pads; the insertion groove is provided with two inner side walls, the tops of the two inner side walls protrude inwards to form limiting strips, the limiting strips extend along the axial direction of the insertion groove, and the depth of the insertion groove is gradually reduced along the direction from inside to outside of the external component; the soft rubber cushion is provided with an inner end face which is abutted against the external component, the middle part of the inner end face is convexly provided with the clamping part, the height of the clamping part is gradually increased along the direction from outside to inside of the soft rubber cushion, the clamping part is pushed into the insertion groove from outside to inside, and the soft rubber cushion is buckled and connected with the external component.
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