CN114190930A

CN114190930A - Underwear with physiological parameter monitoring function and preparation method thereof

Info

Publication number: CN114190930A
Application number: CN202111471693.9A
Authority: CN
Inventors: 张洪艳; 王水莲; 王锐; 张婉茹; 崔晓晴
Original assignee: Beijing Institute Fashion Technology
Current assignee: Beijing Institute Fashion Technology
Priority date: 2021-12-03
Filing date: 2021-12-03
Publication date: 2022-03-18

Abstract

The invention provides an underwear with a physiological parameter monitoring function and a preparation method thereof. This underwear includes: the underwear body is made of elastic close-fitting fabric; the sensor group comprises N flexible sensors integrated on the inner side of the underwear body, wherein N is more than or equal to 1, and the N flexible sensors are attached to corresponding parts of the upper body by means of the elasticity of the elastic close-fitting fabric; the flexible signal processing module is integrated on the underwear body, is electrically connected with the N flexible sensors through conductive fibers blended to the elastic close-fitting fabric, and is used for acquiring sensing signals obtained by the N flexible sensors and transmitting physiological parameter data obtained by the sensing signals to the outside in a wireless mode; and the power supply module is used for supplying power to the flexible signal processing module. The invention clings a plurality of flexible sensors to the human body by the elasticity of the elastic tight-fitting fabric, thereby being capable of comprehensively knowing the health condition of the human body and realizing the measurement and monitoring at any time and any place.

Description

Underwear with physiological parameter monitoring function and preparation method thereof

Technical Field

The invention relates to the field of wearable intelligent equipment and the field of clothes, in particular to underwear with a physiological parameter monitoring function and a preparation method thereof.

Background

Nowadays, science and technology and living standard are continuously improved, internet and intelligent equipment are rapidly developed, health consciousness of people is increased day by day, long-term health monitoring is helpful for preventing and reducing health problems, and with the emphasis of medical care, disease prevention and early detection and chronic disease monitoring are turned to, so that the demand on wearable sensing devices is also increased.

Body temperature, pulse, blood oxygen and sweat are important physiological indexes of a human body, real-time monitoring of the body temperature is helpful for understanding physical health of disabled groups and infants, real-time monitoring of the pulse and the blood oxygen plays a very critical role in prevention and treatment of cardiovascular diseases and lung diseases, lactic acid and glucose in the sweat can be used as important physiological parameters to evaluate health conditions as components of body fluid of the human body, most of the body health monitoring instruments on the market at present are large-size instruments, the wearable equipment is not portable and can not be monitored anytime and anywhere, and the manufacturing cost is high, so that the preparation of wearable equipment capable of being monitored in real time is increasingly important.

Disclosure of Invention

Technical problem to be solved

The present invention is intended to solve at least one of the above technical problems at least in part.

(II) technical scheme

To achieve the above object, according to one aspect of the present invention, there is provided an undergarment with a physiological parameter monitoring function, including: the underwear body is made of elastic close-fitting fabric; the sensor group comprises N flexible sensors integrated on the inner side of the underwear body, wherein N is more than or equal to 1, and the N flexible sensors are attached to corresponding parts of the upper body by means of the elasticity of the elastic close-fitting fabric; the flexible signal processing module is integrated on the underwear body, is electrically connected with the N flexible sensors through conductive fibers blended to the elastic close-fitting fabric, and is used for acquiring sensing signals obtained by the N flexible sensors and transmitting physiological parameter data obtained by the sensing signals to the outside in a wireless mode; and the power supply module is used for supplying power to the flexible signal processing module.

In some embodiments of the invention, the conductive fibers are secured to the elastic yarn in a serpentine configuration to form a conductive fiber/elastic yarn composite; the conductive fiber/elastic yarn composite thread is wrapped in the conductive cloth adhered with the thermoplastic film; and blending the wrapped conductive fiber/elastic yarn composite thread into the elastic close-fitting fabric.

In some embodiments of the invention, the N flexible sensors comprise: the flexible sweat sensor is integrated at the chest position of the underwear body; a flexible sweat sensor comprising: a flexible substrate; and a micro-channel formed on the flexible substrate, wherein two groups of detection areas are formed in the micro-channel: the first set of detection regions includes two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and lactate oxidase are formed in the second chamber in advance in sequence; a second set of detection regions comprising two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and glucose oxidase are formed in the second chamber in advance in sequence; the graphene electrodes of the four chambers are electrically connected to the corresponding conductive fibers.

In some embodiments of the invention, the flexible substrate is a PET film and the fluidic channel is formed from PDMS; the areas of the inlet and the outlet of the micro-channel are larger than the areas of the two sweat glands at the chest position.

In some embodiments of the invention, the N flexible sensors comprise: the flexible pressure sensor is integrated at the position of the cuff of the underwear body; the flexible pressure sensor includes: a corrugated flexible substrate; an electrode layer formed on the flexible substrate; the pressure-sensitive layer is electrically connected to the electrode layer and is of a grid structure; wherein, the electrode layer and the pressure sensitive layer are in a corresponding wrinkle shape corresponding to the shape of the flexible substrate.

In some embodiments of the invention, in the flexible pressure sensor: the flexible substrate is a PDMS film; the material of the electrode layer is silver nanoparticles; the pressure-sensitive layer is made of a composite material of PDMS and carbon nanotubes; the thickness of the flexible pressure sensor is less than 5 mm.

In some embodiments of the invention, the N flexible sensors comprise: the flexible temperature sensor is integrated at the armpit position of the underwear body; the flexible temperature sensor includes: a flexible substrate; the temperature-sensitive pattern is formed on the flexible substrate and is in a snake shape or a spiral shape; the protective layer is formed on the temperature-sensitive pattern and the flexible substrate which is not covered by the temperature-sensitive pattern; wherein the flexible substrate is a PET film; the protective layer is made of PDMS; the material of the temperature-sensitive pattern is one of the following materials: carbon nanotubes, graphene, Mxene, or PEDOT-PSS composite materials; the thickness of the flexible temperature sensor is less than 1 mm.

In some embodiments of the invention, the N flexible sensors comprise: the flexible blood oxygen sensor is integrated at the position of the cuff of the underwear body; the flexible blood oxygen sensor comprises: a flexible substrate; the organic light emitting diode and the organic photoelectric diode are respectively formed on the flexible substrate and are cured and packaged through ultraviolet curing glue; the organic light emitting diode is used as a light source and emits light with different wavelengths; the organic photodiode receives light with different wavelengths reflected by oxygenated hemoglobin and non-oxygenated hemoglobin in blood, converts the light into an electrical signal and transmits the electrical signal to the flexible signal processing module, wherein the electrical signal contains the information of the blood oxygen saturation, and the flexible substrate is made of a PET film.

In some embodiments of the invention, the elastic tight is a spandex blend.

In some embodiments of the invention, the flexible signal processing module transmits the physiological parameter data to the outside by means of bluetooth.

In some embodiments of the invention, the undergarment body is one of the following garments: upper body underwear, conjoined underwear, autumn clothing, and night clothing.

In some embodiments of the present invention, the N flexible sensors are attached by adhesive backing, enclosed in a pouch on the undergarment body, or printed directly to the inside of the undergarment body.

In some embodiments of the invention, the undergarment further comprises: and the flexible electroluminescent module is electrically connected with the flexible signal processing module and is used for sending out an alarm light signal when the body temperature data exceeds a preset alarm threshold value.

In some embodiments of the invention, the undergarment further comprises: the flexible power supply module provides power supply for the flexible signal processing module in a thermoelectric power generation mode, and generates power by utilizing the temperature difference between the body temperature of a human body and the external environment through thermoelectric materials.

In order to achieve the above object, according to a second aspect of the present invention, there is also provided a method of manufacturing the above underwear, comprising:

step A, blending conductive fibers in the elastic tight-fitting fabric of the underwear body on paths between the N flexible sensors and the flexible signal processing module;

b, preparing N flexible sensors and flexible signal processing modules;

step C, integrating the N flexible sensors and the flexible signal processing module at a preset position of the underwear body;

and E, realizing the electrical connection between the flexible signal processing module and the N flexible sensors through the conductive fibers.

In some embodiments of the invention, the N flexible sensors comprise: flexible sweat sensor, flexible pressure sensor, flexible temperature sensor, flexible blood oxygen sensor.

In some embodiments of the invention, in step B, the step of preparing a flexible sweat sensor comprises: preparing the lower layer part of the micro-channel on the PET film by adopting a dispensing printing mode; two sets of detection regions are formed within the microchannel: the first set of detection regions includes two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and lactate oxidase are formed in the second chamber in advance in sequence; a second set of detection regions comprising two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and glucose oxidase are formed in the second chamber in advance in sequence; and then, printing the upper layer part of the micro-channel by adopting a dispensing printing mode, thereby forming the flexible sweat sensor.

In some embodiments of the present invention, in step B, the step of preparing a flexible pressure sensor comprises: forming an electrode layer on the wrinkled PDMS film in an ink-jet printing mode, wherein the electrode layer is made of a silver nano material; adopting a dispensing printing mode to form a latticed pressure-sensitive layer on the electrode layer, wherein the pressure-sensitive layer is made of a composite material of PDMS and carbon nanotubes, and the mass ratio of the PDMS to the carbon nanotubes is 7: 3.

in some embodiments of the invention, in step B, the step of preparing a flexible temperature sensor comprises: obtaining temperature-sensitive ink; printing the temperature-sensitive ink on a flexible substrate in an ink-jet printing mode to form a temperature-sensitive pattern; packaging the temperature-sensitive pattern by PDMS; the solute of the temperature-sensitive ink is a composite conductive material of silver nanoparticles and PEDOT (PSS), and the solvent is ethanol; in the temperature-sensitive ink, the mass concentration of the silver nanoparticles is 5.1%; the mass concentration of PEDOT to PSS is 15.2%.

In some embodiments of the present invention, in step B, the step of preparing the flexible blood oxygen sensor comprises: preparing an organic light-emitting diode and an organic photodiode on the PET film by adopting a dispensing printing mode; and curing and packaging the organic light-emitting diode and the organic photoelectric diode by using ultraviolet glue curing glue.

(III) advantageous effects

According to the technical scheme, the invention has at least one of the following beneficial effects:

(1) the underwear body is integrated with the plurality of flexible sensors, the plurality of flexible sensors are tightly attached to the human body by means of the elasticity of the elastic tight fabric, the flexible sensors with various detection functions are combined with clothing, the health condition of the human body can be comprehensively known, the measurement and monitoring at any time and any place are realized, the natural measurement of physiological parameters of the human body is realized, the daily health condition of the human body can be more accurately reflected, the situation that the abnormal condition of the health cannot be truly reflected at that time is avoided, and the measurement accuracy and the real-time performance are improved.

Specifically, the integrated flexible temperature sensor in the armpit position can acquire body temperature data, the integrated flexible pressure sensor in the cuff position can acquire pulse and blood pressure data, the integrated flexible blood oxygen sensor in the cuff position can acquire blood oxygen data, and the integrated sweat sensor in the chest position can acquire the lactic acid level and the glucose level of sweat.

(2) The four sensors and the signal processing module are all in flexible design and are of sheet structures, so that the discomfort of a human body can be reduced as much as possible, and the acceptance of target people is improved.

In addition, adopt conductive fiber to connect between sensor and the signal processing module, the conductive fiber who connects each module combines together with elastic yarn, and conductive fiber is fixed on elastic yarn with snakelike crooked structure to conductive fiber can adapt to tensile deformation when the human body is worn, keeps signal transmission stability. Meanwhile, the stretchable conductive fiber/elastic yarn composite thread is wrapped by the conductive cloth adhered with the thermoplastic film, the thermoplastic film can generate an insulating effect on the conductive fibers, and the conductive cloth can generate an electromagnetic shielding effect on the conductive fibers. The conductive fiber treated by insulation and electromagnetic shielding can promote stable signal transmission and reduce interference factors. Meanwhile, the diameter of the composite thread cannot be obviously increased by adopting the conductive cloth adhered with the thermoplastic film for wrapping, and the normal blending process cannot be influenced.

(3) A flexible sweat sensor is prepared on a flexible substrate PET film in a dispensing mode, the structure of the flexible sweat sensor is in a micro-channel mode, and lactate oxidase and glucose oxidase are respectively coated at different positions of the sensor. After sweat flows through the two positions, the reagent generates an electric signal according to the lactic acid level and the glucose level of the sweat, and the electric signal is transmitted to the signal processing module, so that the lactic acid level and the glucose level of a user can be measured.

Through the mode, the natural measurement of the physiological parameters of the human body is realized, the real-time observation is convenient, and the measurement convenience is improved.

(4) Preparing a capacitive flexible pressure sensor by using a mode of combining ink-jet printing and dispensing, wherein a pressure-sensitive material is a composite material of PDMS and carbon nano tubes, and is prepared by using a dispensing mode; the electrode layer is made of silver nanoparticles by adopting an ink-jet printing mode; and adjusting the working parameters of the ink-jet printer and the dispensing machine, such as air pressure, printing and dispensing speed, dispensing height and the like, to optimize the performance of the sensor. The substrate selects the wrinkled PDMS film so as to create a wrinkled electrode when the electrode is printed on the PDMS film, the pressure sensitive layer is provided with a latticed microstructure to improve the sensitivity of the pressure sensor, the prepared pressure sensor is connected to a circuit module through silver conductive fibers, and a capacitance signal is input to detect the pulse.

Through the flexible substrate of fold to electrode layer and pressure sensitive layer on it present the fold form simultaneously, adopt PDMS and carbon nanotube's combined material preparation pressure sensitive layer, set up pressure sensitive layer into latticedly simultaneously, thereby promoted sensing signal's intensity and the sensitivity of sensor greatly.

(5) The flexible blood oxygen sensor is prepared by adopting a printing mode, a flexible PET substrate is selected as the substrate, the blood oxygen sensor comprises two parts, namely an organic light emitting diode and an organic photoelectric diode, the blood oxygen sensor is prepared by adopting a dispensing printing mode, the device is packaged by using ultraviolet curing glue, the whole structural design is compact, and the whole sensor patch is controlled to be 1cm²Within.

Through above setting, when realizing noninvasive monitoring, promoted the real-time and the accuracy of blood oxygen detection, can provide long-term blood oxygen data, can diagnose for the later stage and provide reliable foundation.

(6) The planar flexible temperature sensor prepared by adopting the ink-jet printing mode avoids the defects of small temperature sensing area and poor temperature measurement stability of the traditional temperature sensor, improves the wearing comfort and the preparation convenience of a human body, and is favorable for accurate recording and output of data.

(7) The flexible signal processing module is manufactured by utilizing the flexible circuit board to carry out signal acquisition, processing and transmission, the circuit board is flexible, comfortable to wear and strong in wearability, a complete sensor perception-signal acquisition system is realized, and the integration level and the use convenience are improved.

Simultaneously, through the signal acquisition system integration to a circuit with flexible temperature sensor, flexible pressure sensor, flexible sweat sensor and flexible blood oxygen sensor, reduced the drawback that a plurality of circuits were dressed, and interference factor when can reducing signal acquisition through circuit design improves signal output's accuracy and stability.

(9) In the preparation process, the mode of ink-jet printing and dispensing printing is adopted, so that each flexible sensor and each signal processing module can be manufactured more conveniently and accurately, and meanwhile, the method has the advantage of low cost and is beneficial to popularization and application.

(10) All the flexible sensors are prepared on the flexible substrate in a printing mode, and the preparation is simple, efficient and economical. And the flexible sensor is combined with underwear, so that the underwear is convenient to wear and can be monitored in real time.

Drawings

Fig. 1 is a schematic structural diagram of an undergarment with a physiological parameter monitoring function according to an embodiment of the present invention.

Figure 2 is a schematic view of the electrical connections in the undergarment shown in figure 1.

Fig. 3A is a cross-sectional view of a flexible sweat sensor in the undergarment shown in fig. 1. Such as

Fig. 3B is a schematic diagram of the measurement of glucose and lactate levels in the flexible sweat sensor shown in fig. 3A.

Fig. 4 is a flow chart of a method of making the undergarment shown in fig. 1.

Detailed Description

The invention combines the flexible sensors with various detection functions with the clothes, provides the underwear with the physiological parameter monitoring function, realizes the real-time non-invasive monitoring of various human body physiological indexes, and simultaneously can ensure the wearing comfort as much as possible.

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to specific embodiments and the accompanying drawings.

One, underwear body

In one exemplary embodiment of the present invention, an undergarment having a physiological parameter monitoring function is provided. Fig. 1 is a schematic structural diagram of an undergarment with a physiological parameter monitoring function according to an embodiment of the present invention. Figure 2 is a schematic view of the electrical connections in the undergarment shown in figure 1.

As shown in fig. 1 and fig. 2, the underwear with physiological parameter monitoring function of the present embodiment includes: an undergarment body 100; the sensor group comprises four flexible sensors integrated on the inner side of the underwear body; the flexible signal processing module 250 is integrated on the underwear body, is electrically connected with the four flexible sensors through conductive fibers, and is used for acquiring sensing signals obtained by the four flexible sensors and wirelessly transmitting physiological parameters obtained by the sensing signals to the outside; the flexible power supply module 260 is connected to the flexible signal processing module and used for supplying power to the flexible signal processing module; and a flexible electroluminescent module 270 connected to the flexible signal processing module for emitting an alarm light signal in case of emergency, the definition of the emergency being determined by the relevant logic of the flexible signal processing module.

The four flexible sensors specifically include: the flexible temperature sensor 210 is integrated at the armpit position of the underwear body and used for collecting the body temperature information of a human body in real time; the flexible pressure sensor 220 is integrated at the position of the cuff of the underwear body and is used for collecting the blood pressure and pulse information of a human body in real time; the flexible blood oxygen sensor 230 is integrated at the position of the cuff of the underwear body and is used for collecting the information of the blood oxygen saturation of the human body in real time; and the flexible sweat sensor 240 is integrated at the chest position of the underwear body and used for collecting human physiological information reflected in sweat discharged by a human body in real time.

Regarding the underwear with physiological parameter monitoring function of the present embodiment, the following aspects are specifically explained in general terms:

1. elastic close-fitting fabric

In this embodiment, the undergarment body can be one of the following garments: underwear jacket, conjoined underwear, autumn clothing, night clothing, etc. The fabric of the underwear body is made of elastic tight-fitting fabric which is mostly made of spandex blended fabric. The elasticity of the fabric is utilized so that each flexible sensor can be tightly combined with the skin, and corresponding signals can be accurately and stably acquired.

2. The gum behind the flexible sensor facilitates the preparation of the undergarment

In the invention, a flexible temperature sensor, a flexible pressure sensor, a flexible blood oxygen sensor signal and a flexible sweat sensor are integrated on an underwear body in one of the following modes: directly printing the printing ink on the inner side of the cloth of the underwear body; secondly, the flexible substrate is independently formed on the flexible substrate, and then the flexible substrate is adhered and sewn on the cloth of the underwear body or is arranged in a packaging bag on the underwear body.

In the embodiment, the flexible substrates for preparing the four flexible sensors are provided with the back glue, so that the flexible sensors can be pasted to the garment body through the back glue after being prepared, and the preparation method has the advantages of simplicity, convenience and effectiveness.

Therefore, through the fixing mode of adhesion, the flexible sensor can be manufactured independently from the underwear body, the manufacturing efficiency and the sensor precision are greatly improved, and the cost is saved.

3. Comfort design

It is particularly emphasized that in the present embodiment, the flexible temperature sensor 210, the flexible pressure sensor 220, the flexible blood oxygen sensor 230, and the flexible sweat sensor 240 are all in a sheet-like structure. Wherein, flexible temperature sensor with be sheet structure, length-width ratio is 1: 1, all the materials are 10mm, and the thickness is 0.5 mm; the length-width ratio of the flexible blood oxygen sensor is 2:1, the length-width ratio is 20mm and 10mm respectively, and the thickness is 2 mm; the length-width ratio of the flexible sweat sensor is 2:1, the length-width ratio is 20mm and 10mm respectively, the diameter of a sweat inlet channel is 0.5mm, the diameter of the cavity is 3mm, and the diameter of the micro-channel part is 0.1 mm; the flexible pressure sensor is of a sandwich structure, the upper layer and the lower layer are electrodes, and the middle is a pressure-sensitive layer. The length-width ratio is 1: 1, 10mm each and 3mm thick pressure sensitive layer.

In addition, each flexible sensor and the signal processing module are connected through conductive fibers, the conductive fibers for connecting the modules are combined with the elastic yarns, and the conductive fibers are fixed on the elastic yarns in a serpentine bending structure so as to adapt to stretching deformation when a human body wears and keep signal transmission stability in the stretching process. The stretchable conductive fiber/elastic yarn composite thread is wrapped by the conductive cloth adhered with the thermoplastic film, the thermoplastic film can generate an insulating effect on the conductive fibers, and the conductive cloth can generate an electromagnetic shielding effect on the conductive fibers. The conductive fiber treated by insulation and electromagnetic shielding can promote stable signal transmission and reduce interference factors.

It is thus clear that, in this embodiment, design four flexible sensor, signal processing module for plane flexible construction, with conductive fiber blending to the surface fabric in the middle of, be favorable to the user to wear this underwear more comfortably, no matter be daily activity daytime or the rest of evening, can avoid user's conflict mood and the signal line of breaking of contact between accident to reflect user's true physiological state better, for diagnosing the true information of person feedback.

4. All-round detection

In the embodiment, the flexible sensor with multiple detection functions is combined with the garment, so that the health condition of a human body can be known in an all-around manner, measurement and monitoring at any time and any place are realized, natural measurement of physiological parameters of the human body is realized, the daily health condition of the human body can be reflected more accurately, the situation that the abnormal health condition cannot be reflected in real time during measurement is avoided, and the accuracy and the real-time performance of measurement are improved.

The four sensors and associated modules are described in detail below.

1. Flexible temperature sensor

Referring to fig. 1, a flexible temperature sensor 210 is integrated in the underarm position of the undergarment body. From whole, flexible temperature sensor with be sheet structure, length and width ratio is 1: 1, 10mm in thickness and 0.5mm in thickness.

The flexible temperature sensor includes, as viewed in a thickness direction: a flexible substrate; the temperature-sensitive pattern is formed on the flexible substrate and is in a snake shape or a spiral shape; and the protective layer is formed on the temperature-sensitive pattern and the flexible substrate which is not covered by the temperature-sensitive pattern.

In this embodiment, the flexible substrate is a PET film; the protective layer is made of PDMS; the material of the temperature-sensitive pattern is a composite material of silver nanoparticles and PEDOT (PEDOT-positive electrode material) and PSS (negative electrode material), wherein the mass ratio of the silver nanoparticles to the PEDOT-positive electrode material to the PSS is 1: 3.

In the flexible temperature sensor of other embodiments of the present invention, the flexible substrate PET film can also be replaced by other flexible substrates, and the temperature sensitive ink can be selected from other materials with better conductivity and larger resistance change with temperature, such as: carbon nanomaterial composites, graphene, Mxene (a class of two-dimensional inorganic compounds consisting of several atomic layer thick transition metal carbides, nitrides or carbonitrides with hydroxyl or terminal oxygen on the surface and metallic conductivity of transition metal carbides), and the like.

Regarding the flexible temperature sensor, it should be particularly noted that, in the present embodiment, the shape of the temperature sensitive pattern is designed to be a serpentine shape or a spiral shape, which can resist the interference caused by bending deformation and stretching, and improve the accuracy of measurement.

2. Flexible sweat sensor

Referring to fig. 1, a flexible sweat sensor 240 is integrated at the chest of the undergarment body. From the whole view, the length-width ratio of the flexible sweat sensor is 2:1, 20mm and 10mm respectively, the diameter of the sweat inlet channel is 0.5mm, the diameter of the cavity is 3mm, and the diameter of the micro-channel part is 0.1 mm.

On the flexible sweat sensor, a substrate selects a flexible PET film, a Y-shaped micro-channel design form is adopted, and the micro-channel structure is realized by dispensing and printing PDMS. Lactate oxidase and glucose oxidase are used for detecting lactic acid and glucose, and graphene is used as an electrode.

Fig. 3A is a cross-sectional view of a flexible sweat sensor in the undergarment shown in fig. 1. As shown in fig. 3A, two detection regions are formed in the micro flow channel: a lactate detection zone; a glucose detection zone.

(1) In the glucose detection area, a chamber a and a chamber b are provided, the diameter of each chamber is 3mm, graphene electrodes which are pre-coated are arranged in the chamber a and the chamber b, and glucose oxidase is coated on the graphene electrodes in the chamber b and is used for detecting glucose.

(2) In the lactic acid detection area, a chamber c and a chamber d are provided, the diameter of each chamber is 3mm, graphene electrodes which are pre-coated are arranged in the chamber c and the chamber d, and lactate oxidase is coated on the graphene electrodes in the chamber d and is used for detecting lactic acid.

At the inlet of the microchannel is a microchannel for flow of sweat with a diameter of 100 μm. To facilitate sweat inflow, the diameter of the microchannel at the inlet is enlarged to 0.5mm, and is connected to the microchannel to allow inflow of sweat, and the diameter of the inlet channel can cover 2-3 sweat glands on the chest. Thus, the osmotic pressure differential between sweat and blood produced by sweat may draw sweat into the microchannel by hydraulic pressure, and collected sweat may be directed to each chamber through the bifurcated flow channel. Due to the symmetrical design, the rate of sweat flow through each chamber is the same, allowing for high time consistency in the analysis of lactate and glucose. At the bottom of the chamber there is an outlet for sweat, the area of which is also larger than the area of the 2 sweat glands at the chest position.

Fig. 3B is a schematic diagram of the measurement of glucose and lactate levels in the flexible sweat sensor shown in fig. 3A. Referring to fig. 3B, graphene can be used as an electrode as well as an electron transfer function. On the anode, electrons are generated, lactic acid in sweat is oxidized into pyruvic acid by lactate oxidase, and glucose is oxidized into gluconic acid by glucose oxidase; on the cathode, electrons are obtained and oxygen is reduced to water. Thereby generating an electrical potential. According to the concentration difference of the lactic acid and the glucose, the degree of the oxidation-reduction reaction is different, so that the generated potential is different, and the concentration of the lactic acid and the glucose can be judged according to different voltage signals collected by a circuit. The graphene layer as an electrode may also be replaced by a metal electrode such as a gold electrode. However, it can be understood by those skilled in the art that if the electrode layer is a metal electrode, a graphene layer needs to be coated on the metal electrode for electron transport.

Regarding the flexible sweat sensor, it should be particularly noted that the flexible sweat sensor in this embodiment is convenient to wear, and can perform non-invasive monitoring on human physiological indexes, such as the lactic acid level and the glucose level of sweat, so that the physiological index parameters are continuously, conveniently and naturally obtained, the defect that a sweat sample is not easy to obtain in common detection is avoided, real-time observation is facilitated, and the convenience of measurement is improved. On the other hand, the data obtained by connecting the flexible signal processing module to the flexible signal processing module is accurate, real-time monitoring can be carried out, and the data are output through a mobile phone, so that the convenience of measurement is improved.

3. Flexible pressure sensor

Referring to fig. 1, the flexible pressure sensor 220 is integrated at the cuff position of the underwear body. The flexible pressure sensor includes: a corrugated flexible substrate; an electrode layer formed on the flexible substrate; the pressure-sensitive layer is electrically connected to the electrode layer and is of a grid structure; wherein, the electrode layer and the pressure sensitive layer are in a corresponding wrinkle shape corresponding to the shape of the flexible substrate.

Specifically, in this embodiment, the flexible substrate is a PDMS film; the material of the electrode layer is silver nanoparticles; the pressure-sensitive layer is made of a composite material of PDMS and carbon nanotubes.

It is understood that the microstructure of the pressure-sensitive layer can be changed from grid shape to cylinder shape or pyramid shape, and the electrode layer can be made of PEDOT: PSS instead of silver nano-particles.

In particular, in this embodiment, the electrode layer and the pressure-sensitive layer of the flexible pressure sensor are designed with microstructures, so that the sensitivity of the pressure sensor is improved, the detection range is expanded, and the performance is stable.

4. Flexible blood oxygen sensor

Referring to fig. 1, the blood oxygen sensor 230 is integrated at the cuff of the underwear body. This flexible blood oxygen sensor includes: the flexible substrate is made of a PET film; the organic light emitting diode and the organic photoelectric diode are packaged on the flexible substrate through ultraviolet curing glue.

Among these, the principle of blood oxygen monitoring is that oxygenated and non-oxygenated hemoglobin in blood absorb light differently at different wavelengths. Therefore, in the flexible blood oxygen sensor of the present embodiment, the organic light emitting diode serves as a light source to emit light with different wavelengths, the light with different wavelengths is reflected by blood, the organic photodiode receives the light reflected by the hemoglobin containing oxygen and the hemoglobin not containing oxygen in the blood, and converts the light into an electrical signal, and the electrical signal is transmitted to the flexible signal processing module, and the electrical signal contains the information of the blood oxygen saturation.

It can be understood that the organic light emitting diode and the organic photodiode may be made of different light emitting materials and electrodes, and the package may also be made of PDMS instead of uv curable adhesive.

5. Flexible signal processing module

In fig. 1, the location of the flexible signal processing module is not shown. In fact, the position of the flexible signal processing module can be adjusted according to the needs, and can be preferably arranged on the shoulder, the back, the chest and the like.

Referring to fig. 2, the signal input terminal of the flexible signal processing module 250 is connected to the flexible pressure sensor 220, the flexible temperature sensor 210, the flexible blood oxygen sensor 230, and the flexible sweat sensor 240, and includes:

the flexible circuit board is used as a physical carrier of each subsequent functional unit;

a sweat and pressure signal analyzing unit 251 for analyzing signals collected by the flexible sweat sensor and the pressure sensor;

a blood oxygen signal analyzing unit 252, configured to analyze the signal acquired by the flexible blood oxygen sensor;

a temperature signal analyzing unit 253 for analyzing the signal collected by the flexible temperature sensor;

the first embedded data acquisition unit 254 is used for performing signal acquisition on the analyzed sweat and pressure signals to obtain pulse and blood pressure data; and lactate level data and glucose level data in sweat;

the second embedded data acquisition unit 256 is used for performing signal acquisition on the analyzed blood oxygen signal and temperature signal to obtain blood oxygen data and body temperature data;

a bluetooth transmission unit 255 for transmitting pulse and blood pressure data; lactic acid and glucose data, blood oxygen data and body temperature data in sweat are transmitted to the outside through a Bluetooth mode.

Through the setting, the collection and the output of body temperature, pulse, blood pressure, sweat and blood oxygen are carried out, and the real-time monitoring of physiological indexes such as body temperature, pulse lactic acid, glucose and blood oxygen is realized by outputting the collected physiological indexes to the developed specific mobile phone software through Bluetooth.

As to the flexible signal processing module, it should be specifically mentioned that:

1. the flexible signal processing module is designed to collect signals, the circuit board is flexible, the wearing is comfortable, the wearable performance is high, a complete sensor sensing-circuit collecting system is realized, and the integration level and the use convenience are improved.

2. Through the signal acquisition system integration with flexible temperature sensor, pressure sensor, sweat sensor and flexible blood oxygen sensor to a signal processing and transmission circuit in, reduced the drawback that a plurality of circuits were dressed, and interference factor when can reducing signal acquisition through circuit design improves signal output's accuracy and stability.

3. Besides bluetooth, other wireless transmission modes can be adopted for transmitting the physiological index data.

6. Flexible power supply module

Referring to fig. 2, the undergarment with physiological parameter monitoring function of the present embodiment further includes: and the flexible power supply module 260 is connected to the flexible signal processing module and used for supplying power to the flexible signal processing module.

In this embodiment, flexible power module adopts thermoelectric generation's mode to provide the power, through thermoelectric material, utilizes the difference in temperature between human body temperature and the external environment to generate electricity, provides the power for whole circuit system, need not external power supply. The thermoelectric material is PEDOT, PSS and carbon nanotube composite material. The wearing complexity caused by an external power supply is avoided by the thermoelectric power generation mode.

In fact, the invention may also not include a thermoelectric generation module. In a scenario where the user is still to be detected, the battery can be used to directly supply power to the flexible signal processing module, and the invention should also be within the protection scope of the present invention.

7. Flexible electroluminescent module

Referring to fig. 2, the flexible signal processing module 250 further includes: and the light-emitting driving unit 257 is connected to the second embedded data acquisition unit.

Referring to fig. 2, the undergarment with physiological parameter monitoring function of the present embodiment further includes: and a flexible electro-luminescence module 270 connected to the light-emitting driving unit 257 in the flexible signal processing module.

The second embedded data acquisition unit 256 executes the following control logic: when the body temperature data exceeds the preset alarm threshold, the flexible electroluminescent module 270 is driven by the light-emitting driving unit 257 to emit an alarm light signal.

The arrangement is considered, if the body temperature data exceeds the alarm threshold value, the user is in a dangerous situation, the user waits for the mobile phone APP to find danger and make treatment, rescue opportunity may be delayed, at the moment, the user is reminded to the user or asks for help from surrounding people by means of the optical alarm signal, the user can be guaranteed to be timely rescued to the greatest extent, and the rescue opportunity is prevented from being delayed.

Second, preparation method of underwear body

According to another aspect of the invention, a method for preparing the underwear is also provided. It should be noted that the contents related to the underwear examples are all incorporated into the preparation method examples, and the description is not repeated.

It should be particularly noted that, in this embodiment, four kinds of flexible sensors are all prepared by printing, or ink-jet printing, or dispensing printing, and the preparation process is simple, economical and practical, and the manufacturing cost is low.

Fig. 4 is a flow chart of a method of making the undergarment shown in fig. 1. As shown in fig. 4, the method for manufacturing the underwear with physiological parameter monitoring function of the embodiment includes:

step A, blending conductive fibers at the following positions of the fabric of the underwear body:

presetting a position between a flexible temperature sensor and a flexible signal processing module;

presetting a position between the flexible pressure sensor and the flexible signal processing module;

presetting a position between the flexible blood oxygen sensor and the flexible signal processing module;

fourthly, the position between the flexible sweat sensor and the flexible signal processing module is preset;

the position of a preset flexible power supply module and the position of a preset flexible signal processing module;

and sixthly, the position between the preset flexible electroluminescent module and the preset flexible signal processing module.

By blending the conductive fibers into the fabric, the signal connecting wire can be prevented from being exposed outside the underwear body, and therefore the signal connecting wire can be prevented from being accidentally hung up by a user; and secondly, the wearing comfort of the user can be improved. For the combination of the conductive fibers with the elastic yarns, the wrapping of the conductive cloth, and the like, reference is made to the description of the previous embodiments.

Step B, preparing independent flexible temperature sensors, flexible pressure sensors, flexible blood oxygen sensors and flexible sweat sensors;

in the embodiment, the flexible temperature sensor, the flexible pressure sensor, the flexible sweat sensor and the flexible blood oxygen sensor are printed on the organic high molecular polymer substrate in an ink-jet printing or dispensing manner, and the back of the substrate is glued or directly packaged and then embedded into the garment material, so that the process difficulty and the preparation cost are effectively reduced.

And a sub-step B1 of preparing a resistance type flexible temperature sensor on the polymer substrate by using an ink-jet printing mode.

Firstly, preparing temperature-sensitive ink, wherein in the temperature-sensitive ink, a solute is a composite conductive material of silver nano-particles and PEDOT (Poly ethylene glycol ether ketone) PSS, a solvent is ethanol, and the mass concentration of the silver nano-particles is 5.1%; the mass concentration of PEDOT to PSS is 15.2%.

Secondly, preparing a resistance type flexible temperature sensor on the polymer substrate by using an ink-jet printing mode;

during this time, the performance of the temperature sensor is optimized by adjusting the process parameters of the printing process, such as the operating voltage of the inkjet printer, the printing frequency, the heating temperature, etc. The polymer substrate is a PET film, the performance of the temperature-sensitive ink is improved by adjusting the material proportion and selecting a proper solvent, so that the sensitivity of the prepared device is improved, and the resistance of the composite material is increased along with the increase of the temperature. The printed flexible temperature sensor is packaged by PDMS after being cured at 120 ℃ so as to isolate air and moisture, so that the flexible temperature sensor can stably work for a long time when monitoring the body temperature of a human body.

It should be particularly noted that in the invention, the temperature-sensitive ink is adopted and prepared into the conductive temperature-sensitive ink by adjusting the solvent ratio, adding the dispersant, the adhesive and the like, and the performance of the flexible temperature sensor is optimized by adjusting the technological parameters of the ink-jet printing process, so that the sensitivity of the temperature sensor is improved, and the flexible temperature sensor can accurately measure the body temperature of a human body. Meanwhile, the planar flexible temperature sensor prepared by adopting an ink-jet printing mode avoids the defects of small temperature sensing area and poor temperature measurement stability of the traditional temperature sensor, improves the wearing comfort and the preparation convenience of a human body, and is favorable for accurate recording and output of data.

Sub-step B2, preparing a capacitance type flexible pressure sensor by combining ink-jet printing and dispensing;

in the sub-step, the pressure-sensitive material is prepared by selecting a composite material of PDMS and carbon nano tubes in a dispensing manner; the electrode layer is made of silver nanoparticles by ink-jet printing and dispensing.

And adjusting the working parameters of the ink-jet printer and the dispensing machine, such as air pressure, printing and dispensing speed, dispensing height and the like, to optimize the performance of the sensor. The substrate selects the wrinkled PDMS film so as to create the wrinkled electrode when the electrode is printed on the PDMS film, the pressure sensitive layer is provided with a grid-shaped microstructure to improve the sensitivity of the pressure sensor, and the prepared flexible pressure sensor is connected to the flexible signal processing module through the silver conductive fibers.

In addition, the flexible pressure sensor prepared by adopting the mode of combining ink-jet printing and dispensing is high in sensitivity, wide in detection range, simple to prepare, low in cost, comfortable and convenient to wear and capable of continuously measuring the pulse of a human body in real time.

A substep B3, preparing a flexible blood oxygen sensor by adopting a dispensing printing mode;

in the substep, the substrate selects a flexible PET substrate, the sensor comprises two parts, namely an organic light emitting diode and an organic photodiode, the sensor is prepared in a dispensing printing mode, ultraviolet curing glue is used for packaging the device, the whole structure design is compact, the whole sensor patch is controlled within 1 square centimeter, signals are output through a customized flexible signal processing module, and the signals and the signal acquisition of the temperature and pressure sensors are set in a circuit board for real-time non-invasive monitoring.

It should be noted that, in the present invention, the flexible blood oxygen sensor is prepared by printing instead of the traditional mask method, the blood oxygen sensor is prepared at low cost, the organic light emitting diode and the organic photodiode are designed compactly, and the overall size does not exceed 1 square centimeter, so that the organic photodiode can efficiently utilize the light emitted by the organic light emitting diode, and then the light is subjected to photoelectric conversion and is collected in real time by the circuit board and output signals to perform blood oxygen monitoring.

And a substep B4, preparing a flexible sweat sensor on the flexible substrate PET film by adopting a dispensing printing mode.

The method specifically comprises the following steps: preparing the lower layer part of the micro-channel on the PET film by adopting a dispensing printing mode; preparing four chambers in the micro flow channel, and forming a graphene electrode and corresponding oxidase in the chambers; and printing the upper layer part of the micro-channel by adopting a dispensing printing mode.

Step C, integrating a flexible temperature sensor at the armpit position of the underwear body; integrating a flexible pressure sensor and a flexible blood oxygen sensor at the cuff position of the underwear body; a flexible sweat sensor is integrated at the chest position of the underwear body; integrating a flexible signal processing module at the position of a chest part of the underwear body;

d, fixing a flexible electroluminescent module and a flexible power supply module at the position of the chest of the underwear body;

and E, realizing the electrical connection between the flexible signal processing module and the four sensors, the flexible power supply module and the flexible electroluminescent module through the conductive fibers.

The connection between each sensor and the flexible signal processing module is realized through the conductive fiber in the cloth, so that the preparation of the underwear with the physiological parameter monitoring function is completed, and the method specifically comprises the following steps:

1. connection between sensor and flexible signal processing module

The pins of the flexible sweat sensor, the flexible temperature sensor, the flexible pressure sensor and the flexible blood oxygen sensor are led out by silver conductive fibers so as to be connected with a circuit board for testing, and after the testing is finished, the flexible temperature sensor is connected to the flexible signal processing module through the conductive fibers in the reserved fabric.

2. The flexible signal processing module is connected with the power supply module, and the power supply module is used for supplying power to the flexible signal processing module;

3. the connection between the flexible signal processing module and the flexible electroluminescent module,

thus, the embodiments of the method of making the undergarment of the present invention have been described.

It is noted that for some implementations, if not essential to the invention and well known to those of ordinary skill in the art, they are not illustrated in detail in the drawings or in the text of the description, as they may be understood with reference to the relevant prior art.

Further, it is to be understood that these embodiments are provided merely to enable the invention to meet statutory requirements, and that the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Further, the above definitions of the various elements and methods are not limited to the various specific structures, shapes or arrangements of parts mentioned in the examples, which may be easily modified or substituted by those of ordinary skill in the art.

Thus, various embodiments of the present invention have been described in detail and with particular reference to the accompanying drawings. The present invention should be clearly recognized by those skilled in the art from the above description.

In conclusion, the invention combines the flexible sensors with various detection functions with the clothes, realizes the real-time noninvasive monitoring of various human body physiological indexes, and is the first case in domestic and foreign research. The sensor and the signal analysis circuit are connected by adopting conductive fibers, the conductive fibers can conduct electricity and have higher softness and flexibility, and the conductive fibers are mixed and woven into yarns of the garment fabric, so that the problems of discomfort in wearing and inconvenience in washing caused by external wires are solved.

It should be noted that directional terms, such as "upper", "lower", "front", "rear", "left", "right", "inner", "outer", etc., referred to in the text of the embodiments and the drawings are only directions of reference of the drawings, and are not intended to limit the scope of the present invention. Throughout the drawings, like elements are represented by like or similar reference numerals. Conventional structures or constructions will be omitted when they may obscure the understanding of the present invention.

And the shapes and sizes of the respective components in the drawings do not reflect actual sizes and proportions, but merely illustrate contents of the embodiments of the present invention. Furthermore, in the claims, any reference signs placed between parentheses shall not be construed as limiting the claim.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms can be understood in a specific case to those of ordinary skill in the art.

Unless expressly indicated to the contrary, the numerical parameters set forth in the specification and claims of this invention may be approximations that may vary depending upon the teachings of the invention. In particular, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about," which is intended to be interpreted to mean including within the meaning of a specified amount, in some embodiments, a variation of ± 10%, in some embodiments, a variation of ± 5%, in some embodiments, a variation of ± 1%, and in some embodiments, a variation of ± 0.5%.

Furthermore, the word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.

In addition, unless steps are specifically described or must occur in sequence, the order of the steps is not limited to that listed above and may be changed or rearranged as desired by the desired design. The embodiments described above may be mixed and matched with each other or with other embodiments based on design and reliability considerations, i.e., technical features in different embodiments may be freely combined to form further embodiments.

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An undergarment with a physiological parameter monitoring function, comprising:

the underwear body is made of elastic close-fitting fabric; and

the sensor group comprises N flexible sensors which are integrated on the inner side of the underwear body, wherein N is more than or equal to 1, and the N flexible sensors are attached to the corresponding parts of the upper body by means of the elasticity of the elastic close-fitting fabric;

the flexible signal processing module is integrated with the underwear body, is electrically connected with the N flexible sensors through conductive fibers blended to the elastic close-fitting fabric, and is used for acquiring sensing signals obtained by the N flexible sensors and transmitting physiological parameter data obtained by the sensing signals to the outside in a wireless mode;

and the power supply module is used for supplying power to the flexible signal processing module.

2. The undergarment according to claim 1 wherein the conductive fibers are secured to the elastic yarns in a serpentine configuration to form a conductive fiber/elastic yarn composite;

the conductive fiber/elastic yarn composite thread is wrapped in the conductive cloth adhered with the thermoplastic film; and blending the wrapped conductive fiber/elastic yarn composite thread into the elastic close-fitting fabric.

3. The undergarment according to claim 1, wherein:

the N flexible sensors include: the flexible sweat sensor is integrated at the chest position of the underwear body;

the flexible sweat sensor includes:

a flexible substrate; and

a microchannel formed on the flexible substrate, two sets of detection regions formed in the microchannel:

the first set of detection regions includes two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and lactate oxidase are formed in the second chamber in advance in sequence;

a second set of detection regions comprising two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and glucose oxidase are formed in the second chamber in advance in sequence;

the graphene electrodes of the four chambers are electrically connected to the corresponding conductive fibers.

4. The undergarment according to claim 3, wherein the flexible substrate is a PET film and the micro flow channels are formed from PDMS; the areas of the inlet and the outlet of the micro-channel are larger than the areas of the two sweat glands at the chest position.

5. The undergarment according to claim 1, wherein:

the N flexible sensors include: the flexible pressure sensor is integrated at the position of the cuff of the underwear body;

the flexible pressure sensor includes:

a corrugated flexible substrate;

an electrode layer formed on the flexible substrate;

the pressure-sensitive layer is electrically connected to the electrode layer and is of a grid structure;

wherein the electrode layer and the pressure-sensitive layer are correspondingly wrinkled corresponding to the shape of the flexible substrate.

6. The undergarment according to claim 5 wherein the flexible pressure sensor has: the flexible substrate is a PDMS film; the electrode layer is made of silver nanoparticles; the pressure-sensitive layer is made of a composite material of PDMS and carbon nanotubes; the thickness of the flexible pressure sensor is less than 5 mm.

7. The undergarment according to claim 1, wherein:

the N flexible sensors include: the flexible temperature sensor is integrated at the armpit position of the underwear body; the flexible temperature sensor includes: a flexible substrate; the temperature-sensitive pattern is formed on the flexible substrate and is in a snake shape or a spiral shape; the protective layer is formed on the temperature-sensitive pattern and the flexible substrate which is not covered by the temperature-sensitive pattern; wherein the flexible substrate is a PET film; the protective layer is made of PDMS; the material of the temperature-sensitive pattern is one of the following materials: PSS, carbon nanotubes, graphene, Mxene, or PEDOT; the thickness of the flexible temperature sensor is less than 1 mm; and/or

The N flexible sensors include: the flexible blood oxygen sensor is integrated at the position of the cuff of the underwear body; the flexible blood oxygen sensor comprises: a flexible substrate; the organic light emitting diode and the organic photoelectric diode are respectively formed on the flexible substrate and are cured and packaged through ultraviolet curing glue; the organic light emitting diode is used as a light source and emits light with different wavelengths; the organic photodiode receives light with different wavelengths reflected by oxygen-containing hemoglobin and non-oxygen-containing hemoglobin in blood, converts the light into an electric signal and transmits the electric signal to the flexible signal processing module, wherein the electric signal contains the information of the blood oxygen saturation, and the flexible substrate is made of a PET (polyethylene terephthalate) film.

8. The undergarment according to claim 1, wherein:

the elastic close-fitting fabric is a spandex blended fabric; and/or

The flexible signal processing module transmits physiological parameter data to the outside in a Bluetooth mode; and/or

The underwear body is one of the following clothes: upper body underwear, coveralls, autumn clothing, and pajamas; and/or

The N flexible sensors are adhered through back glue and are arranged in a packaging bag on the underwear body, or the N flexible sensors are directly printed on the inner side of the underwear body; and/or

The undergarment further includes: the flexible electroluminescence module is electrically connected with the flexible signal processing module and is used for sending out an alarm light signal when the body temperature data exceeds a preset alarm threshold value; and/or

The undergarment further includes: the flexible power supply module adopts a thermoelectric power generation mode to supply power to the flexible signal processing module, and generates power by utilizing the temperature difference between the body temperature of a human body and the external environment through thermoelectric materials.

9. A method of making the undergarment of any of claims 1 to 8, comprising:

b, preparing N flexible sensors and flexible signal processing modules;

10. The method of manufacturing of claim 9, wherein the N flexible sensors comprise: flexible sweat sensor, flexible pressure sensor, flexible temperature sensor, flexible blood oxygen sensor, wherein:

in step B, the step of preparing a flexible sweat sensor comprises: preparing the lower layer part of the micro-channel on the PET film by adopting a dispensing printing mode; two sets of detection regions are formed within the microchannel: the first set of detection regions includes two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and lactate oxidase are formed in the second chamber in advance in sequence; a second set of detection regions comprising two chambers; only a graphene electrode is formed in the first chamber in advance; a graphene electrode and glucose oxidase are formed in the second chamber in advance in sequence; then, printing the upper layer part of the micro-channel by adopting a dispensing printing mode so as to form a flexible sweat sensor; and/or

In the step B, the step of preparing the flexible pressure sensor includes: forming an electrode layer on the wrinkled PDMS film in an ink-jet printing mode, wherein the electrode layer is made of a silver nano material; forming a latticed pressure-sensitive layer on the electrode layer by adopting a dispensing printing mode, wherein the pressure-sensitive layer is made of a composite material of PDMS and carbon nanotubes, and the mass ratio of the PDMS to the carbon nanotubes is 7: 3; and/or

In the step B, the step of preparing the flexible temperature sensor includes: obtaining temperature-sensitive ink; printing the temperature-sensitive ink on a flexible substrate in an ink-jet printing mode to form a temperature-sensitive pattern; encapsulating the temperature-sensitive pattern with PDMS; the solute of the temperature-sensitive ink is a composite conductive material of silver nanoparticles and PEDOT (PSS), and the solvent is ethanol; in the temperature-sensitive ink, the mass concentration of the silver nanoparticles is 5.1%; the mass concentration of PEDOT and PSS is 15.2%; and/or

In the step B, the step of preparing the flexible blood oxygen sensor comprises: preparing an organic light-emitting diode and an organic photodiode on the PET film by adopting a dispensing printing mode; and curing and packaging the organic light-emitting diode and the organic photoelectric diode by using ultraviolet glue curing glue.