CN114184774A - Sample room seal structure and cartridge for molecular detection - Google Patents

Abstract

The application relates to biological sample storage equipment technical field, especially relates to a sample room seal structure and cartridge for molecular detection. The sample chamber sealing structure comprises a sample chamber main body, a sealing piece, a sealing cover plate and a main cover plate; the sample chamber main body is provided with a sample chamber, the sealing element is placed on the end face of the open end of the sample chamber, and the sealing cover plate is pressed on the sealing element and can seal the open end of the sample chamber; the main cover plate is buckled with the sample chamber main body and is pressed on the sealing cover plate, so that the sealing cover plate seals and seals the sample chamber through a sealing element; the main cover plate is provided with a second sample inlet, and the sealing cover plate can move to open or close the sample cabin; when the sample chamber is opened, the biological sample can be injected into the sample chamber through the second sample inlet; after the sample is injected, the sealing cover plate plugs the sample cabin again, so that the sample cabin is kept in a sealed state, and the leakage of the biological sample or the pollution of the biological sample is avoided.

Description

Sample room seal structure and cartridge for molecular detection

Technical Field

The application relates to the technical field of biological sample storage equipment, in particular to a sample chamber sealing structure and a molecular detection card box.

Background

The sample is stored in some occasions and needs to be sealed, so that the sample chamber needs to be sealed in some occasions. For example, when the sample chamber is used for storing biological samples, the sample chamber needs to be sealed and protected in order to prevent the biological samples from being polluted or some pathogenic biological samples (such as viruses) from being leaked and polluted in the situations such as during the experiment or after the device is recycled.

Disclosure of Invention

The invention aims to provide a sample chamber sealing structure and a cartridge for molecular detection, which are used for sealing and storing a sample and preventing the sample from leaking or diffusing and polluting.

The invention provides a sample chamber sealing structure which comprises a sample chamber main body, a sealing piece, a sealing cover plate and a main cover plate, wherein the main cover plate is arranged on the main body; a sample cabin is formed in the sample chamber main body, and the sealing cover is covered at the open end of the sample cabin; the main cover plate is connected with the open end of the sample chamber main body, and the main cover plate is covered on the sealing cover plate in a pressing manner; the sealing piece is positioned between the sealing cover plate and the sample cabin so that the sealing cover plate can seal and block the open end of the sample cabin; the sealing cover plate can move to open or close the sample cabin; the main cover plate forms a second sample inlet, and when the sample cabin is opened, the second sample inlet is communicated with the sample cabin.

Further, the sealing member is a sealing gasket; a first sample inlet is formed in the sealing gasket, and the first sample inlet and the second sample inlet are located on the same axis.

Furthermore, a limiting shaft is formed at one end of the sealing cover plate, and the limiting shaft is positioned on the surface of one side of the sealing cover plate, which faces the sample cabin; a limiting groove is formed in the sample chamber main body, and the limiting shaft can extend into the limiting groove; an operating handle is formed at the other end of the sealing cover plate and is positioned on the plate surface of one side, facing the main cover plate, of the sealing cover plate; the main cover plate forms a guide hole through which the operating handle can pass.

Further, the guide hole comprises a first guide part which is arc-shaped, and the operating handle can move from a first end of the first guide part to a second end of the first guide part, so that the sealing cover plate rotates around the limiting shaft by a preset angle; and when the operating handle is positioned at the second end of the first guide part, the sample chamber is opened.

Furthermore, the limiting groove is strip-shaped, and the length direction of the limiting groove extends along the first direction; the guide hole further comprises a second guide part, the second guide part is strip-shaped, a first end of the second guide part is communicated with a first end of the first guide part, and a second end of the second guide part extends along the first direction; the operating handle can move to the second end of the second guide part through the first end of the first guide part, and when the operating handle moves to the second end of the second guide part, the limiting shaft moves to the second end of the limiting groove from the first end of the limiting groove.

Furthermore, a positioning hole is formed in the bottom wall of the second end of the limiting groove; when the limiting shaft moves to the second end of the limiting groove, the lower end of the limiting shaft can extend into the positioning hole.

Furthermore, the sample chamber sealing structure also comprises a locking block, the locking block is provided with a through hole, and when the operating handle is positioned at the first end of the first guide part, the locking block is sleeved on the operating handle through the through hole; the locking block is formed with at least one boss, and at least one boss can be inserted into the guide hole.

Further, a step portion is formed on an end face of the open end of the sample compartment; the sealing member is mounted in the stepped portion, and an end face of the sealing member protrudes a predetermined height from an end face of the sample compartment.

Further, a cementing layer is arranged between the sealing element and the end face of the open end of the sample cabin; the seal is adhered to the end face of the open end of the sample compartment by the glue layer.

The invention also provides a cartridge for molecular detection, comprising the sample chamber sealing structure.

Compared with the prior art, the invention has the beneficial effects that:

the invention provides a sample chamber sealing structure which comprises a sample chamber main body, a sealing piece, a sealing cover plate and a main cover plate; wherein, a sample cabin for storing biological samples is formed inside the sample chamber main body, and when the sample chamber main body is horizontally arranged, the upper ends of the sample chamber main body and the sample cabin are open ends. The sealing member is placed on the terminal surface of the open end of sample cabin, and sealed apron is pressed on the sealing member, and sealed apron can carry out the shutoff to the open end of sample cabin. The main cover plate can be buckled at the open end of the sample chamber main body, and when the main cover plate is buckled with the sample chamber main body, the main cover plate is pressed on the sealing cover plate, downward pressure is applied to the sealing cover plate, the sealing cover plate is enabled to compress the sealing element downwards, the sealing element has elasticity, the sealing element is enabled to deform when stressed, and therefore the sealing cover plate can seal and block the open end of the sample chamber, and a sample is sealed and stored in the sample chamber. The main cover plate is provided with a second sample inlet, the sealing cover plate can move, and the sample chamber can be opened or closed by moving the sealing cover plate; when a biological sample needs to be injected into the sample chamber, the sealing cover plate is moved to open the sample chamber, and an operator can inject the biological sample into the sample chamber through the second sample inlet; after the injection of the biological sample is completed, the sealing cover plate is moved back to the initial position, and the sealing cover plate seals and seals the sample cabin again to enable the sample cabin to be in a sealing state again, so that the biological sample is prevented from leaking or being polluted.

The invention also provides a cartridge for molecular detection, which comprises the sample chamber sealing structure, so that the cartridge for molecular detection also has the beneficial effect of the sample chamber sealing structure.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic structural diagram of a sample chamber sealing structure provided by an embodiment of the present invention at a first viewing angle;

FIG. 2 is a schematic diagram of a split structure of a sealing structure of a sample chamber provided in an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a sample chamber body according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a main cover plate according to an embodiment of the present invention;

FIG. 5 is a schematic structural diagram of a sealing cover plate according to an embodiment of the present invention;

FIG. 6 is a schematic diagram of a sample chamber sealing structure provided by an embodiment of the present invention from a second perspective;

FIG. 7 is a schematic cross-sectional view taken along line A-A of FIG. 6;

FIG. 8 is a schematic view of an operating handle provided in accordance with an embodiment of the present invention positioned at a first end of a first guide portion;

FIG. 9 is a schematic view of an operating handle provided by an embodiment of the present invention at a second end of the first guide portion;

fig. 10 is a schematic view of the operating handle provided in the embodiment of the present invention at the second end of the second guide portion.

Reference numerals:

1-a sample chamber body, 11-a buckle, 2-a sample cabin, 21-a step part, 3-a sealing element, 31-a first sample inlet, 4-a sealing cover plate, 41-a limiting shaft, 42-an operating handle, 5-a main cover plate, 51-a second sample inlet, 6-a locking block, 7-a guide hole, 71-a first guide part, 72-a second guide part, 8-a limiting groove and 81-a positioning hole.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention.

The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.

All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

A sample chamber sealing structure and a cartridge for molecular detection according to some embodiments of the present application are described below with reference to fig. 1 to 10.

The present application provides a sample chamber sealing structure, as shown in fig. 1, 2 and 7, comprising a sample chamber main body 1, a sealing member 3, a sealing cover plate 4 and a main cover plate 5; wherein, a sample chamber 2 for storing samples is formed inside the sample chamber main body 1, and when the sample chamber main body 1 is horizontally placed, the upper ends of the sample chamber main body 1 and the sample chamber 2 are both open ends; the sealing element 3 is placed on the end face of the open end of the sample compartment 2, the sealing cover plate 4 is pressed on the sealing element 3, and the sealing cover plate 4 can seal the open end of the sample compartment 2. Main apron 5 can the lock in the open end of sample room main part 1, and when main apron 5 buckled with sample room main part 1 mutually, main apron 5 will be suppressed on sealed apron 4 to exert decurrent pressure to sealed apron 4, make sealed apron 4 compress tightly sealing member 3 downwards, sealing member 3 has elasticity and makes sealing member 3 take place deformation when the atress, thereby make sealed apron 4 can seal the shutoff to the open end of sample cabin 2, make the sealed shutoff of sample deposit in sample cabin 2.

The sealing cover 4, which is located between the sealing element 3 and the main cover 5, is movable. Preferably, as shown in fig. 2 and 5, one end of the sealing cover plate 4 is formed with a limiting shaft 41, and the limiting shaft 41 is located on one side plate surface of the sealing cover plate 4 facing the sample chamber 2; the other end of the sealing cover plate 4 is formed with an operating handle 42, and the operating handle 42 is located on one side plate surface of the sealing cover plate 4 facing the main cover plate 5. A rib plate is formed at one end of the outer side of the sample chamber 2 in the sample chamber main body 1, and a limit groove 8 (refer to fig. 3) is formed on the rib plate; as shown in fig. 6 and 7, one end of the sealing cover plate 4 provided with the stopper shaft 41 can extend to the stopper groove 8, and the stopper shaft 41 can be inserted into the stopper groove 8. The main cover plate 5 is provided with a guide hole 7 at a position corresponding to the operating handle 42 of the sealing cover plate 4, so that the operating handle 42 can pass through the main cover plate 5 through the guide hole 7 and extend out of the main cover plate 5 by a predetermined height. As shown in fig. 4, the guide hole 7 includes a first guide portion 71, and the first guide portion 71 has an arc shape; when the operating handle 42 is pulled to enable the operating handle 42 to move from the first end of the first guide part 71 to the second end of the first guide part 71, the sealing cover plate 4 rotates for a preset angle around the limiting shaft 41, so that a part of the open end of the sample chamber 2 is exposed, and the sample chamber 2 is opened; so that the sealing cover plate 4 can be rotated to open or close the sample chamber 2 by pulling the operating handle 42 to reciprocate in the first guide portion 71.

The main cover plate 5 is provided with a second sample inlet 51, and when the sample chamber 2 is opened by rotating the sealing cover plate 4, the second sample inlet 51 is positioned right above the exposed open end of the sample chamber 2, so that a sample can be injected into the sample chamber 2 through the second sample inlet 51. After the injection of the sample is completed, the sealing cover plate 4 is rotated again, so that the sealing cover plate 4 is reset, the sample cabin 2 is sealed and blocked again, and the sample is prevented from leaking or diffusing pollution.

In one embodiment of the present application, preferably, as shown in fig. 2, the sealing member 3 is a sealing gasket covering the open end of the sample chamber 2; the gasket is provided with a first sample inlet 31, and the first sample inlet 31 and the second sample inlet 51 are located on the same axis. Referring to fig. 8, when the operating handle 42 is located at the first end of the first guiding portion 71, the sealing cover plate 4 is located between the sealing member 3 and the main cover plate 5, and the sealing cover plate 4 completely covers the sealing member 3, so that the first sample inlet 31 and the second sample inlet 51 cannot be communicated through the separation of the sealing cover plate 4, and the sealing cover plate 4 is tightly pressed on the sealing member 3 under the action of the main cover plate 5, the sealing cover plate 4 can seal and block the first sample inlet 31 on the sealing member 3, and the sample chamber 2 is in a sealed state. Referring to fig. 9, when the operating handle 42 moves from the first end of the first guide portion 71 to the second end of the first guide portion 71, the sealing cover plate 4 rotates by a predetermined angle around the limiting shaft 41, so that the sealing cover plate 4 blocked between the first sample inlet 31 and the second sample inlet 51 is removed, the first sample inlet 31 on the sealing member 3 is exposed, and thus the sample chamber 2 is opened, the second sample inlet 51 on the main cover plate 5 can communicate with the sample chamber 2 through the first sample inlet 31, and an operator can inject a sample into the sample chamber 2 through the first sample inlet 31 and the second sample inlet 51; after the injection of the sample is completed, the operating handle 42 is pulled, so that the operating handle 42 returns to the second end of the first guiding part 71 from the second end of the first guiding part 71, the sealing cover plate 4 covers the first sample inlet 31 again to seal and seal the first sample inlet 31, the sample chamber 2 is in a sealing state again, the sample is prevented from leaking or diffusing pollution, and a better sealing effect can be realized by preferably selecting a sealing gasket.

In one embodiment of the present application, it is preferable that, as shown in fig. 3, a step portion 21 is formed on an end surface of the open end of the sample chamber 2, and the sealing member 3 is embedded and installed in the step portion 21, so as to reduce the risk of the sealing cover plate 4 moving and the sealing member 3 moving. Preferably, the upper end surface of the sealing member 3 protrudes a predetermined height above the upper end surface of the sample compartment 2, so that the sealing member 3 is compressed by a sufficient amount to achieve a better sealing effect.

In this embodiment, a glue layer is preferably arranged between the face of the open end of the sample compartment 2 and the sealing member 3, so that the sealing member 3 is stably and firmly mounted to the open end of the sample compartment 2, so that the sealing cover plate 4 can seal and seal the sample compartment 2 by means of the sealing member 3. Preferably, a glue layer is provided on the stepped portion 21 so that the sealing member 3 can be adhered to the stepped surface of the stepped portion 21 by the glue layer.

In one embodiment of the present application, preferably, as shown in fig. 2 and 4, the guide hole 7 further includes a second guide portion 72, preferably, the second guide portion 72 has a bar shape, and a length direction of the second guide portion 72 extends in the first direction; both ends of the second guide portion 72 in the length direction thereof are a first end of the second guide portion 72 and a second end of the second guide portion 72, and the first end of the second guide portion 72 is adjacent to and connected to the first end of the first guide portion 71. Preferably, the length direction of the first guide portion 71, i.e., the first direction, is along a radial line direction in which the first guide portion 71 passes through the first end of the first guide portion 71.

In this embodiment, preferably, as shown in fig. 2 and 3, the limiting groove 8 is a strip-shaped groove, the length direction of the limiting groove 8 extends along the first direction, and two ends of the limiting groove 8 along the length direction thereof are respectively a first end of the limiting groove 8 and a second end of the limiting groove 8; when the operating handle 42 is located at the first end of the first guide portion 71, the stopper shaft 41 is located at the first end of the stopper groove 8, and the seal cover plate 4 can be rotated around the stopper shaft 41 by pulling the handle in the longitudinal direction of the first guide portion 71. When the operating handle 42 is located at the first end of the first guiding portion 71 and the limiting shaft 41 is located at the first end of the limiting groove 8, the operating handle 42 is pulled along the length direction of the second guiding portion 72, i.e., the first direction, so that the operating handle 42 moves from the first end of the first guiding portion 71 to the second end of the second guiding portion 72, the sealing cover plate 4 translates along the first direction for a predetermined distance, and the limiting shaft 41 moves along with the first guiding portion, so that the limiting shaft 41 moves from the first end of the limiting groove 8 to the second end of the limiting groove 8.

In this embodiment, preferably, as shown in fig. 7, a positioning hole 81 is formed in a bottom wall of the second end of the limiting groove 8, and when the limiting groove 8 moves to the second end of the limiting groove 8, since the sealing cover plate 4 is pressed downward by the main cover plate 5, the sealing cover plate 4 can continuously press the sealing member 3 downward, so that the sealing member 3 continuously deforms, and the sealing cover plate 4 can move downward by a predetermined distance, so that the lower end of the limiting shaft 41 extends into the positioning hole 81. At this time, the operating handle 42 is located at the second end of the second guiding portion 72, and because the limiting shaft 41 is inserted into the positioning hole 81, the limiting shaft 41 cannot return to the first end of the limiting groove 8, and the operating handle 42 cannot return to the first end of the first guiding portion 71, so that the operating handle 42 and the sealing cover plate 4 cannot rotate around the limiting shaft 41, the sample chamber 2 cannot be opened, the sample chamber 2 keeps a closed state, and a sample in the sample chamber 2 cannot leak due to misoperation.

During a particular use, the initial position of the operating handle 42 is located at a first end of the first guide portion 71; when an operator needs to inject a sample into the sample chamber 2, the operating handle 42 is pulled from the first end of the first guiding portion 71 to the second end of the first guiding portion 71, the first sample inlet 31 on the sealing member 3 is opened, and the operator injects the sample into the sample chamber 2 through the second sample inlet 51 on the main cover plate 5 and the first sample inlet 31 on the sealing member 3. After the injection of the sample is completed, the operating handle 42 is pulled to the second end of the second guiding part 72 from the second end of the first guiding part 71 through the first end of the first guiding part 71, the limiting shaft 41 on the sealing cover plate 4 is clamped into the positioning hole 81 of the bottom wall of the limiting groove 8, so that the sealing cover plate 4 cannot move continuously, the sample chamber 2 cannot be opened continuously, the sample chamber 2 is always in a closed state, and the sample cannot leak in the experimental process or the subsequent recovery process.

In an embodiment of the present application, preferably, as shown in fig. 2 and 7, the sample chamber sealing structure further includes a locking block 6, and the locking block 6 is provided with a through hole. When the operating handle 42 is located at the first end of the first guide portion 71, the locking block 6 can be fitted to the operating handle 42 through the through hole. Preferably, at least one boss is formed on one side of the locking block 6 facing the main cover plate 5. When the locking block 6 is sleeved on the operating handle 42, one boss or a plurality of bosses can be inserted into the guide hole 7, so that the movement of the locking block 6 is limited, and the locking of the operating handle 42 and the sealing cover plate 4 is realized through the locking block 6. Preferably, when the number of the bosses is one, the bosses are to be inserted into the second guide portions 72. Preferably, the locking block 6 is L-shaped and comprises a first plate surface and a second plate surface which are connected with each other; the through-hole and the boss of latch segment 6 all are located first face. The first plate surface is placed on the upper plate surface of the main cover plate 5, and the second plate surface is abutted against the side wall of the main cover plate 5 and the side wall of the sample chamber main body 1; can restrict the activity of latch segment 6 better, and then restrict operating handle 42's activity, make operating handle 42 can't remove in guiding hole 7, operating handle 42 is locked to before guaranteeing not pouring into the sample in sample cabin 2, operating handle 42 can not be because the maloperation is removed to the second end of second guide part 72 and is leaded to sample cabin 2 to fail to open, the matching sample room main part that L shape design can be better simultaneously practices thrift the space.

In an embodiment of the present application, preferably, as shown in fig. 3, a plurality of buckles 11 are formed on a side wall of the sample chamber main body 1, the number of the buckles 11 is plural, the plurality of buckles 11 are symmetrically disposed on side walls of two sides of the sample chamber main body 1, a plurality of clamping grooves are formed on a side wall of the main body cover, the plurality of clamping grooves correspond to the plurality of buckles 11 one to one, the plurality of clamping grooves are symmetrically disposed on two sides of the main body cover, and the buckles 11 can be clamped in the corresponding clamping grooves, so that the main cover plate 5 is firmly fastened on the sample chamber main body 1, and downward pressure is continuously applied to the sealing cover plate 4.

The sample chamber sealing structure is suitable for devices needing sample sealing, such as cartridges for detecting nucleic acid and protein biological materials.

The application also provides a cartridge for molecular detection, comprising the sample chamber sealing structure of any one of the above embodiments.

In this embodiment, the cartridge for molecular detection includes a sample chamber sealing structure, so the cartridge for molecular detection has all the advantages of the sample chamber sealing structure, and will not be described in detail herein.

The sample chamber sealing structures of the present application are preferably used in biological sample processing to prevent the risk of contamination of the biological sample (e.g., a pathogenic biological sample) during the assay or after recovery of the cartridge.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. A sample chamber sealing structure is characterized by comprising a sample chamber main body, a sealing piece, a sealing cover plate and a main cover plate;

a sample cabin is formed in the sample chamber main body, and the sealing cover plate is covered at the open end of the sample cabin;

the main cover plate is connected with the open end of the sample chamber main body, and the main cover plate is covered on the sealing cover plate in a pressing manner;

the sealing element is arranged between the sealing cover plate and the sample cabin, so that the sealing cover plate can seal and plug the open end of the sample cabin;

the sealing cover plate can move to open or close the sample cabin; the main cover plate forms a second sample inlet, and when the sample cabin is opened, the second sample inlet is communicated with the sample cabin.

2. The sample chamber sealing structure of claim 1, wherein the seal is a sealing gasket;

a first sample inlet is formed in the sealing gasket, and the first sample inlet and the second sample inlet are located on the same axis.

3. The sample chamber sealing structure according to claim 1, wherein a limiting shaft is formed at one end of the sealing cover plate, and the limiting shaft is located on a side plate surface of the sealing cover plate facing the sample chamber; a limiting groove is formed in the sample chamber main body, and the limiting shaft can extend into the limiting groove;

an operating handle is formed at the other end of the sealing cover plate and is positioned on the plate surface of one side, facing the main cover plate, of the sealing cover plate; the main cover plate forms a guide hole through which the operating handle can pass.

4. The sample chamber sealing structure of claim 3, wherein the guide hole comprises a first guide portion, the first guide portion is arc-shaped, and the operating handle can move from a first end of the first guide portion to a second end of the first guide portion to rotate the sealing cover plate by a predetermined angle around the limiting shaft; and when the operating handle is positioned at the second end of the first guide part, the sample chamber is opened.

5. The sample chamber sealing structure of claim 4, wherein the limiting groove is strip-shaped, and the length direction of the limiting groove extends along a first direction;

the guide hole further comprises a second guide part, the second guide part is strip-shaped, a first end of the second guide part is communicated with a first end of the first guide part, and a second end of the second guide part extends along the first direction;

the operating handle can move to the second end of the second guide part through the first end of the first guide part, and when the operating handle moves to the second end of the second guide part, the limiting shaft moves to the second end of the limiting groove from the first end of the limiting groove.

6. The sample chamber sealing structure according to claim 5, wherein a positioning hole is formed in the bottom wall of the second end of the limiting groove;

when the limiting shaft moves to the second end of the limiting groove, the lower end of the limiting shaft can extend into the positioning hole.

7. The sample chamber sealing structure of claim 5, further comprising a locking block;

the locking block is provided with a through hole, and when the operating handle is positioned at the first end of the first guide part, the operating handle can be sleeved on the operating handle through the through hole;

the locking block is formed with at least one boss, and at least one boss can be inserted into the guide hole.

8. The sample chamber sealing structure according to any one of claims 1 to 7, wherein a step is formed on an end face of the open end of the sample compartment;

the sealing member is mounted in the stepped portion, and an end face of the sealing member protrudes a predetermined height from an end face of the sample compartment.

9. The sample chamber sealing structure according to any one of claims 1 to 7, wherein a glue layer is provided between the sealing member and the end face of the open end of the sample compartment;

the seal is adhered to the end face of the open end of the sample compartment by the glue layer.

10. A cartridge for molecular detection, comprising a sample chamber sealing structure according to any one of claims 1 to 9.

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