CN114159543A - 预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺 - Google Patents
预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺 Download PDFInfo
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Abstract
本发明公开了一种预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺，它涉及医药技术领域。取黄柏、地肤子、芦荟、苦参、蛇床子，将药材制备成药材粉末，与植物活性硒、胶原蛋白肽及纯化水混合浸渍，将浸渍的混合液在反应容器中加热，过滤，并通过减压蒸馏浓缩成浓缩液；将浓缩液加入尼泊金甲酯及纯化水，再加乙醇溶解，过滤；将所得滤液加金箔充分混合均匀，乳化后形成凝胶；检验合格后，灌装凝胶至给药器内，密封。本发明制备工艺简便，制备而成的凝胶制剂能够预防妇科炎症，见效快，有效提高机体免疫力及内分泌的调节能力，抗衰老，应用前景广阔。
Description
技术领域
本发明涉及的是医药技术领域，具体涉及一种有效针对预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺。
背景技术
现今人们的生活节奏快，精神压力大，尤其是女性，在高强的工作环境下，人体机能下降，加速衰老，免疫力降低，内分泌易紊乱，这些会直接导致妇科炎症的发生，妇科炎症主要是由于细菌感染引起的，会导致女性出现宫颈炎盆腔炎和阴道炎，出现阴道分泌物增多、疼痛、瘙痒、有异味等症状，对女性健康十分不利。基于此，开发一种预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺尤为必要。
发明内容
针对现有技术上存在的不足，本发明目的是在于提供一种预防妇科炎症抗衰老提高免疫力的凝胶制剂和制备工艺，制备工艺简便，制备而成的凝胶制剂能够有效预防妇科炎症，提高免疫力，抗衰老，易于推广使用。
为了实现上述目的，本发明是通过如下的技术方案来实现：预防妇科炎症抗衰老提高免疫力的凝胶制剂，按重量份由以下原料组成：植物活性硒1-2份、胶原蛋白肽0.5-1.5份、黄柏5-10份、地肤子6-9份、芦荟3-7份、苦参10-20份、蛇床子10-15份、金箔0.3-0.6份、尼泊金甲酯0.5-2份、纯化水25-35份。
作为优选，所述的凝胶制剂按重量份由以下原料组成：植物活性硒1.3-1.8份、胶原蛋白肽0.8-1.2份、黄柏6-9份、地肤子7-9份、芦荟4-6份、苦参15-18份、蛇床子12-14份、金箔0.4-0.5份、尼泊金甲酯1-1.5份、纯化水28-32份。
作为优选，所述的凝胶制剂按重量份由以下原料组成：植物活性硒1.5份、胶原蛋白肽1份、黄柏8份、地肤子8份、芦荟5份、苦参16份、蛇床子13份、金箔0.5份、尼泊金甲酯1.2份、纯化水30份。
预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其制备步骤为：(1)按相应重量份选取植物活性硒、胶原蛋白肽、黄柏、地肤子、芦荟、苦参、蛇床子、金箔、尼泊金甲酯、纯化水；
(2)取黄柏、地肤子、芦荟、苦参、蛇床子，将药材制备成药材粉末，与植物活性硒、胶原蛋白肽及纯化水混合浸渍；
(3)将浸渍的混合液在反应容器中加热，过滤，并通过减压蒸馏浓缩成浓缩液；
(4)将浓缩液加入尼泊金甲酯及纯化水，再加乙醇溶解，过滤；
(5)将所得滤液加金箔充分混合均匀，乳化后形成凝胶；
(6)检验合格后，灌装凝胶至给药器内，密封。
作为优选，所述的步骤(2)中黄柏、地肤子、芦荟、苦参、蛇床子与植物活性硒、胶原蛋白肽及纯化水浸渍时间为24-36h。
作为优选，所述的步骤(3)混合液加热分三次，第一次加热至沸腾，保持2h，过滤得到第一过滤液和滤渣，将滤渣加入纯化水进行第二次加热，沸腾状态保持1.5h，过滤得到第二过滤液和滤渣，再将得到的滤渣加入纯化水进行第三次加热，沸腾状态保持1h，过滤得到第三过滤液，将三次过滤液合并即可。
作为优选，所述的步骤(3)中浓缩物的密度为1.3g/ml-1.5g/ml。
本发明的有益效果：本发明制备工艺简便，制备而成的凝胶制剂能够预防妇科炎症，疗效好，见效快，有效提高机体免疫力及内分泌的调节能力，抗衰老，应用前景广阔。
附图说明
下面结合附图和具体实施方式来详细说明本发明；
图1为本发明的制备流程图。
具体实施方式
为使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施方式，进一步阐述本发明。
参照图1，本具体实施方式采用以下技术方案：预防妇科炎症抗衰老提高免疫力的凝胶制剂，按重量份由以下原料组成：植物活性硒1-2份、胶原蛋白肽0.5-1.5份、黄柏5-10份、地肤子6-9份、芦荟3-7份、苦参10-20份、蛇床子10-15份、金箔0.3-0.6份、尼泊金甲酯0.5-2份、纯化水25-35份。
值得注意的是，所述的凝胶制剂按重量份由以下原料组成：植物活性硒1.3-1.8份、胶原蛋白肽0.8-1.2份、黄柏6-9份、地肤子7-9份、芦荟4-6份、苦参15-18份、蛇床子12-14份、金箔0.4-0.5份、尼泊金甲酯1-1.5份、纯化水28-32份。
本具体实施方式凝胶制剂的各组分具体如下：
①植物活性硒：具有高度的生物活性，通过生物转化与氨基酸结合而成，满足人体对硒元素的高效吸收和代谢，生物活性的硒和人体中的重金属和有毒有机化合物结合，清除体内垃圾，排除体内毒素，清除自由基，排除重金属毒物，对人体的健康起到保护作用。
②胶原蛋白肽：作为身体免疫作用中负责重要功能的阿米巴细胞清扫异物的感知器，对预防疾病很有帮助，可提高免疫机能、抑制癌细胞、活化细胞机能，同时有助于子宫内膜的修复。
③黄柏：具有抗病原微生物及病原虫的作用，有清热燥湿、解热抗炎、杀虫止痒的功效，用于治疗外阴炎、阴道炎等多种病症。
④地肤子：清利湿热、止痒，具有抗炎、利尿、免疫抑制作用，对奥杜盎氏小芽孢癣菌、铁锈色小芽孢癣菌等真菌具有一定的抑制作用。
⑤芦荟：含酚类、芦荟素、芦荟酊、有机酸等成分，对某些细菌、真菌、病毒有杀灭作用，同时具有治疗组织损伤作用，对皮肤有防护作用，可刺激成纤维细胞的生长，能促进伤口愈合、抗炎并能增强免疫。
⑥苦参：抗菌消炎，同时还有调节阴道内菌群环境的效果，可用于宫颈炎、滴虫性阴道炎和霉菌性阴道炎。
⑦蛇床子：能降血压、抗真菌，抗变态反应，杀死阴道毛滴虫，对女性健康十分有益，具有燥湿祛风、杀虫止痒之功效，可用于医治女性寒湿带下、阴痒肿痛、外阴湿疹、妇人阴痒、滴虫性阴道炎等。
⑧金箔：能够加强营养物质的导入功能，让其中的有效成分更快、更深入地被吸收，抗氧化性好，有一定的消炎除菌的功效。
⑨尼泊金甲酯：对各种霉菌、酵母菌、细菌有效，能破坏微生物的细胞膜，使细胞内的蛋白质变性，并可抑制微生物细胞的呼吸酶系与电子传递酶系的活性。
本具体实施方式还提供了一种预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其制备步骤为：(1)按相应重量份选取植物活性硒、胶原蛋白肽、黄柏、地肤子、芦荟、苦参、蛇床子、金箔、尼泊金甲酯、纯化水；
(2)取黄柏、地肤子、芦荟、苦参、蛇床子，将药材制备成药材粉末，与植物活性硒、胶原蛋白肽及纯化水混合浸渍；
(3)将浸渍的混合液在反应容器中加热，过滤，并通过减压蒸馏浓缩成浓缩液；
(4)将浓缩液加入尼泊金甲酯及纯化水，再加乙醇溶解，过滤；
(5)将所得滤液加金箔充分混合均匀，乳化后形成凝胶；
(6)检验合格后，灌装凝胶至给药器内，密封。
值得注意的是，所述的步骤(2)中黄柏、地肤子、芦荟、苦参、蛇床子与植物活性硒、胶原蛋白肽及纯化水浸渍时间为24-36h。
本具体实施方式步骤(3)中混合液加热分三次，第一次加热至沸腾，保持2h，过滤得到第一过滤液和滤渣，将滤渣加入纯化水进行第二次加热，沸腾状态保持1.5h，过滤得到第二过滤液和滤渣，再将得到的滤渣加入纯化水进行第三次加热，沸腾状态保持1h，过滤得到第三过滤液，将三次过滤液合并即可。此外，浓缩物的密度为1.3g/ml-1.5g/ml。
实施例1：预防妇科炎症抗衰老提高免疫力的凝胶制剂，由以下重量份的原料组成：植物活性硒1.5份、胶原蛋白肽1份、黄柏8份、地肤子8份、芦荟5份、苦参16份、蛇床子13份、金箔0.5份、尼泊金甲酯1.2份、纯化水30份。其制备步骤为：
(1)按上述重量份选取植物活性硒、胶原蛋白肽、黄柏、地肤子、芦荟、苦参、蛇床子、金箔、尼泊金甲酯、纯化水；
(2)取黄柏8份、地肤子8份、芦荟5份、苦参16份、蛇床子13份，制备成药材粉末，与植物活性硒1.5份、胶原蛋白肽1份及纯化水10份混合浸渍30h；
(3)将浸渍的混合液在反应容器中第一加热，保持2h沸腾，过滤得到第一过滤液和滤渣，将滤渣加入5份纯化水进行第二次加热，沸腾状态保持1.5h，过滤得到第二过滤液和滤渣，再将得到的滤渣加入5份纯化水进行第三次加热，沸腾状态保持1h，过滤得到第三过滤液，将三次过滤液合并，过滤，并通过减压蒸馏浓缩成密度为1.4g/ml的浓缩液；
(4)将浓缩液加入尼泊金甲酯1.2份及纯化水10份，再加乙醇溶解，过滤；
(5)将所得滤液加金箔0.5份充分混合均匀，乳化后形成凝胶；
(6)检验合格后，灌装凝胶至给药器内，密封。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (7)
1.预防妇科炎症抗衰老提高免疫力的凝胶制剂，其特征在于，按重量份由以下原料组成：植物活性硒1-2份、胶原蛋白肽0.5-1.5份、黄柏5-10份、地肤子6-9份、芦荟3-7份、苦参10-20份、蛇床子10-15份、金箔0.3-0.6份、尼泊金甲酯0.5-2份、纯化水25-35份。
2.根据权利要求1所述的预防妇科炎症抗衰老提高免疫力的凝胶制剂，其特征在于，按重量份由以下原料组成：植物活性硒1.3-1.8份、胶原蛋白肽0.8-1.2份、黄柏6-9份、地肤子7-9份、芦荟4-6份、苦参15-18份、蛇床子12-14份、金箔0.4-0.5份、尼泊金甲酯1-1.5份、纯化水28-32份。
3.根据权利要求1所述的预防妇科炎症抗衰老提高免疫力的凝胶制剂，其特征在于，按重量份由以下原料组成：植物活性硒1.5份、胶原蛋白肽1份、黄柏8份、地肤子8份、芦荟5份、苦参16份、蛇床子13份、金箔0.5份、尼泊金甲酯1.2份、纯化水30份。
4.预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其特征在于，其制备步骤为：(1)按相应重量份选取植物活性硒、胶原蛋白肽、黄柏、地肤子、芦荟、苦参、蛇床子、金箔、尼泊金甲酯、纯化水；
(2)取黄柏、地肤子、芦荟、苦参、蛇床子，将药材制备成药材粉末，与植物活性硒、胶原蛋白肽及纯化水混合浸渍；
(3)将浸渍的混合液在反应容器中加热，过滤，并通过减压蒸馏浓缩成浓缩液；
(4)将浓缩液加入尼泊金甲酯及纯化水，再加乙醇溶解，过滤；
(5)将所得滤液加金箔充分混合均匀，乳化后形成凝胶；
(6)检验合格后，灌装凝胶至给药器内，密封。
5.根据权利要求4所述的预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其特征在于，所述的步骤(2)中黄柏、地肤子、芦荟、苦参、蛇床子与植物活性硒、胶原蛋白肽及纯化水浸渍时间为24-36h。
6.根据权利要求4所述的预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其特征在于，所述的步骤(3)混合液加热分三次，第一次加热至沸腾，保持2h，过滤得到第一过滤液和滤渣，将滤渣加入纯化水进行第二次加热，沸腾状态保持1.5h，过滤得到第二过滤液和滤渣，再将得到的滤渣加入纯化水进行第三次加热，沸腾状态保持1h，过滤得到第三过滤液，将三次过滤液合并即可。
7.根据权利要求4所述的预防妇科炎症抗衰老提高免疫力的凝胶制剂的制备工艺，其特征在于，所述的步骤(3)中浓缩物的密度为1.3g/ml-1.5g/ml。
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