CN114159103A - Degradable disposable sampling oral swab - Google Patents
Degradable disposable sampling oral swab Download PDFInfo
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- CN114159103A CN114159103A CN202111390477.1A CN202111390477A CN114159103A CN 114159103 A CN114159103 A CN 114159103A CN 202111390477 A CN202111390477 A CN 202111390477A CN 114159103 A CN114159103 A CN 114159103A
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- connecting rod
- sampling
- handle
- swab
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/14—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyester as constituent
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention relates to the field of oral swabs, and particularly discloses a degradable disposable sampling oral swab. A degradable disposable sampling oral swab comprises a handle, a connecting rod fixedly connected with the handle and a sampling head arranged on the connecting rod, wherein the sampling head consists of a plurality of villi, one end of the villi is fixedly connected to the connecting rod, and the other end of the villi extends towards the direction far away from the connecting rod; the fluff comprises the following components in parts by mass: 10-11 parts of polyhydroxybutyrate; 15-16 parts of polylactic acid; 30-32 parts of polycaprolactone; 3-4 parts of polybutylene succinate; 0.1-0.15 part of antioxidant; the handle and the connecting rod are both made of degradable plastics. The invention has the advantage of reducing plastic pollution.
Description
Technical Field
The invention relates to the field of oral swabs, in particular to a degradable disposable sampling oral swab.
Background
Along with medical treatment level's development, the technique of human sampling analysis state of an illness is more and more mature, human oral cavity sample is the sampling mode commonly used, can sample through the oral cavity swab usually, during the sampling, can stretch into oral cavity one side with the oral cavity swab, scrape 15-20 times from top to bottom in inner wall mucous membrane department, during the sampling, oral cavity inner wall mucous membrane is hugged closely to the oral cavity swab, ensure that the oral cavity swab can dip in and get oral cavity mucous membrane cast-off cells, during the sampling, need all sample through the mode of scraping many times to oral cavity both sides, put into the test tube with the oral cavity swab after the sampling finishes and preserve.
Therefore, the oral swab needs to exert certain acting force in the sampling process, so that the part sampled by the oral swab is usually made of soft materials, and the handle part is also usually made of elastic plastic materials, so that the oral swab counteracts part of the acting force through deformation in the using process, and the comfort of the oral cavity is improved.
Although plastic has elasticity and can deform under stress to reduce discomfort in the mouth, the plastic is generally difficult to degrade, and the mouth swab is a disposable consumable and cannot be reused, which inevitably leads to serious increase of plastic products and plastic pollution, so that the improvement space is provided.
Disclosure of Invention
To reduce plastic contamination, the present application provides a degradable disposable sampling buccal swab.
The application provides a degradable disposable sampling oral cavity swab adopts following technical scheme:
a degradable disposable sampling oral swab comprises a handle, a connecting rod fixedly connected with the handle and a sampling head arranged on the connecting rod, wherein the sampling head consists of a plurality of villi, one end of the villi is fixedly connected on the connecting rod, and the other end of the villi extends towards the direction far away from the connecting rod;
the fluff comprises the following components in parts by mass:
10-11 parts of polyhydroxybutyrate;
15-16 parts of polylactic acid;
30-32 parts of polycaprolactone;
3-4 parts of polybutylene succinate;
0.1-0.15 part of antioxidant;
the handle and the connecting rod are both made of degradable plastics.
Through adopting above-mentioned technical scheme, all adopt degradable plastics to make through handle and connecting rod, the sampling head adopts degradable fine hair to make for the oral cavity swab has the elastic soft of plastics so that can improve the oral cavity when sampling and experience, is difficult for causing plastics to pollute.
Wherein, the sampling head comprises fine hair and fine hair one end is fixed on the connecting rod other end and is extended towards the direction of keeping away from the connecting rod for the sampling head is very soft, and every fine hair homoenergetic adheres the cell that the oral cavity inner wall mucous membrane drops more easily, when improving the oral comfort level, and the sampling effect preferred.
In addition, because the fluff is compounded by polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate, the fluff has better flexibility and higher melting point, the oral cavity swab can be discarded only after being used, if the oral cavity swab is directly discarded, virus and bacteria can be transmitted possibly to cause sanitary accidents, and in order to thoroughly sterilize, the sterilization temperature is usually over 125 ℃ and is heated for 20min, therefore, the specially-made fluff has high melting point, the situation of softening and even melting is not easy to occur in the sterilization process, if the fluff is melted and adhered into a group, the bacteria and the viruses are easily wrapped by the molten high molecular material, the high molecular material blocks the heat transmission, the virus and the bacteria can not be easily killed, and after the high molecular material is degraded, the virus can be released again, which reduces the sterilization and disinfection effect, therefore, the special high melting point villus can ensure better sterilization and disinfection effect and higher safety.
Moreover, the sampling effect of the villus formed by compounding polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate is good, after polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate are compounded, due to the fact that molecular chain structures of all components are inconsistent, after molecular chains of all components are intertwined with each other, the surface of the villus obtained by hot-melt spraying can form a scale-shaped bulge in a macroscopic view, the surface of the villus is not smooth, when the inner wall of the oral cavity is wiped by the villus, the friction force is increased, cells of mucous membranes of the oral cavity are more easily scraped off and adhered to the villus, and the sampling effect is better.
In addition, the fluff compounded by polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate has better flexibility, is not easy to break off during sampling, reduces the condition that the fluff is broken and remained in the oral cavity, is safer and more sanitary, is not easy to prick the mouth, and has better oral cavity experience.
Preferably, each of the piles forms an angle of 88-90 ° with a tangent plane of the connecting rod at the point of connection with the pile.
Through adopting above-mentioned technical scheme, through the special contained angle relation of fine hair and connecting rod for fine hair has the best deformation space, makes fine hair can by make full use of, and the sampling effect preferred, and has better protection to the oral cavity, reduces the damage to the oral cavity, improves the oral cavity comfort better.
Preferably, the length of the fluff is 1.9-2.1 mm.
By adopting the technical scheme, the size of the sampling head is moderate, the sampling quantity is sufficient, the effect is good, the operation is convenient, the operation is flexible, the sampling operation is very convenient, and the serious discomfort to the oral cavity is not easy to cause by specifically selecting the fluff of 1.9-2.1 mm.
Preferably, the handle and the connecting rod are both made of polylactic acid.
Through adopting above-mentioned technical scheme, make handle and connecting rod through polylactic acid, because polylactic acid melting point is higher, be difficult for softening or melting in disinfection process, be difficult for influencing disinfection effect, and because handle and connecting rod need not with oral cavity direct contact, only need have certain elasticity can and if the handle flexibility is too big, also can make the unable operation of oral cavity swab, therefore, handle and connecting rod are made to concrete selection polylactic acid, can make handle and connecting rod have better structural stability, have suitable compliance, be convenient for operate, and also can take place certain deformation when the atress in order to reduce the oral cavity discomfort.
Preferably, a breaking section for connecting the handle and the connecting rod is arranged between the handle and the connecting rod, and the breaking section is made of polyhydroxybutyrate.
Through adopting above-mentioned technical scheme, through the rupture section connection handle and the connecting rod that adopt polyhydroxybutyrate to make, utilize polyhydroxybutyrate to make more fragile characteristic for the rupture section is easily broken, with the handle rupture back, only preserves connecting rod and sampling head, can preserve the cell that the sampling obtained, makes the test tube need not the headspace and supplies the handle to deposit, makes the operation more convenient during sample preservation and subsequent sample analysis.
Preferably, the fluff is bonded to the connecting section by hot-melt polycaprolactone.
Through adopting above-mentioned technical scheme, polycaprolactone through the hot melt bonds fine hair for fine hair is connected comparatively steadily with the connecting rod, is difficult for droing, and polycaprolactone's melting point is lower, can make fine hair drop when the disinfection, makes when collecting, and fine hair pile together is difficult for making the space occupy more because of the fine hair on each connecting rod hinders each other, is convenient for collect the packing after the disinfection and abandons.
Preferably, the handle and the connecting rod are both in a circular tube shape.
Through adopting above-mentioned technical scheme, make handle and connecting rod stress time stress distribution even through the pipe form, the degree that elastic deformation takes place in each direction is close, improves better and uses experience to can reduce the material quantity under the prerequisite that keeps stable in structure, reduce cost reduces the degradation required time, reduce plastics pollution.
Preferably, the break-off section is provided with a marking.
By adopting the technical scheme, the broken section is convenient to find for breaking through the design mark, and the operation is convenient.
In summary, the present application has the following beneficial effects:
1. because this application all adopts degradable plastics to make through handle and connecting rod, the fine hair that the sampling head adopted the degradation is made for the oral cavity swab has the elastic soft of plastics so that can improve the oral cavity body when sampling and test, is difficult for causing plastic pollution.
2. It adopts polyhydroxybutyrate to prefer to adopt the fine hair in this application, polylactic acid, polycaprolactone, polybutylene succinate is compound to form, make the fine hair have higher melting point when having better compliance, purpose-made high melting point fine hair can make the sterile effect of disinfecting preferred, the security is high, and, because inconsistent of each component branch chain structure, after the molecular chain of each component intertwines each other, can embody the fine hair surface that hot melt-blown jetted out and obtain macroscopically and can form the scale arch, make the fine hair surface not smooth, make fine hair when wiping oral cavity inner wall, frictional force increases, it scrapes off and makes the cell adhere on the fine hair to change oral cavity inner wall mucous membrane cell, make the sampling effect preferred.
3. The down of 1.9-2.1mm is preferably selected through concrete in this application for the sampling head size is moderate, and the sampling quantity is sufficient, and the effect is better, and convenient operation, it is comparatively dexterous, and the sampling operation is very convenient, is difficult for causing serious discomfort to the oral cavity.
Detailed Description
The present application will be described in further detail with reference to examples.
The information on the source of the raw materials used in the following preparation examples, comparative examples and examples is shown in Table 1.
TABLE 1
Preparation examples 1 to 3
A fluff, comprising the following components:
polyhydroxybutyrate, polylactic acid, polycaprolactone, polybutylene succinate and an antioxidant.
The specific amounts of the respective raw materials used in preparation examples 1 to 3 are shown in Table 2.
TABLE 2
In preparation examples 1 to 3, the fluff was prepared as follows:
putting polyhydroxybutyrate, polylactic acid, polycaprolactone, polybutylene succinate and an antioxidant into a stirring kettle, stirring at a rotating speed of 120r/min for 2min to obtain a premix.
And (3) putting the uniform mixture into an extruder, extruding at the extrusion temperature of 150 ℃, and performing extrusion granulation to obtain the composite polymer particles.
Putting the composite polymer particles into electrospinning equipment, and preparing the fluff filaments by an electrospinning process, wherein the aperture of a needle is 0.2mm, the spinning voltage is 16kV, and the receiving distance is 18 cm.
And cutting the fine fluff into corresponding sizes to obtain the fluff.
The length of the pile was 1.9mm in preparation example 1, 2mm in preparation example 2, and 2.1mm in preparation example 3.
Comparative example 1
A pile, differing from example 2 only in that:
equal amount of polycaprolactone is used to replace polyhydroxybutyrate.
Comparative example 2
A pile, differing from example 2 only in that:
the polylactic acid is replaced by polycaprolactone with equal quantity.
Comparative example 3
A pile, differing from example 2 only in that:
the poly (butylene succinate) is replaced by polycaprolactone in equal amount.
Example 1
The utility model provides a disposable sampling oral cavity swab of degradable, includes the handle, and the handle is the pipe form, and handle one end fixedly connected with breaks the section, and the section of breaking is pipe form and external diameter unanimous with the handle external diameter, breaks section axis and the coincidence of handle axis, and handle one end fixedly connected with connecting rod is kept away from to the section of breaking, and the connecting rod is the pipe form, and the connecting rod is kept away from handle one end and is sealed, and the connecting rod blind end becomes hemispherical, and the connecting rod axis coincides with the handle axis.
The sampling head is arranged on the connecting rod and consists of a plurality of villi, one end of the villi is fixedly connected to the outer wall of the connecting rod, the other end of the villi extends in the direction away from the connecting rod, and each villi and the tangent plane of the connecting rod at the connecting point of the villi form an included angle of 88-90 degrees.
The outer wall of the broken section is marked with red marked lines.
When the disposable sampling oral swab is used, the handle is held by hand, the sampling head extends into one side of an oral cavity, clings to mucous membrane on the inner wall of the oral cavity for scraping 15-20 times, then reaches the other side of the oral cavity, clings to mucous membrane on the inner wall of the oral cavity for scraping 15-20 times, the degradable disposable sampling oral swab is taken out, the sampling head extends into a test tube, then the sampling head is broken at a marked line, and the test tube is sealed.
The degradable disposable sampling buccal swab is prepared by the following steps:
the preparation method comprises the steps of injection molding polylactic acid raw materials to obtain a handle and a connecting rod through an injection molding process, injection molding polyhydroxybutyrate to obtain a broken section through the injection molding process, heating two ends of the broken section to be hot-melted, and then bonding the handle and the broken section and bonding the connecting rod and the broken section to obtain the oral swab framework.
Smearing the hot-melt polycaprolactone on the outer wall of the connecting rod, planting the fluff on the outer wall of the connecting rod through electrostatic flocking, and cooling to room temperature to obtain the degradable disposable sampling oral swab.
In this example, the pile of preparation example 1 was used as the pile.
Example 2
A degradable disposable sampling buccal swab differing from example 1 only in that:
in this example, the pile of preparation example 2 was used as the pile.
Example 3
A degradable disposable sampling buccal swab differing from example 1 only in that:
in this example, the pile of preparation example 3 was used as the pile.
Example 4
A degradable disposable sampling buccal swab differing from example 1 only in that:
in this example, the pile of comparative example 1 was used as the pile.
Example 5
A degradable disposable sampling buccal swab differing from example 1 only in that:
in this example, the pile of comparative example 2 was used as the pile.
Example 6
A degradable disposable sampling buccal swab differing from example 1 only in that:
in this example, the pile of comparative example 3 was used as the pile.
Experiment 1
The flexural modulus of the samples prepared from the composite polymer materials of preparation examples 1 to 3 and comparative examples 1 to 3 was measured according to GBT9341-2000 method for quantitative flexural Property test.
Experiment 2
The Vicat softening temperatures of the samples prepared from the composite polymer materials of preparation examples 1 to 3 and comparative examples 1 to 3 were measured according to GBT1633-2000 "determination of Vicat Softening Temperature (VST) of thermoplastic plastics".
Experiment 3
The degradable disposable sampling oral swab of examples 1-6 was used to scrape 5 times on the oral side of the volunteer, then the sampling head was soaked in 10ml of saline for 1 hour to obtain the cell sap, 0.05ml of the cell sap was put on a glass slide, the number of cells was observed and recorded by microscope, and after sampling was completed, the oral sensation of the volunteer was recorded.
Experiment 4
Using the degradable disposable sampling buccal swabs of examples 1-6 embedded in soil, observations were made every 24h and the time to complete degradation was recorded.
The specific assay data for experiments 1-4 are detailed in Table 3.
TABLE 3
According to the data in table 3, comparing the data in preparation example 2 with those in comparative examples 1-3, it can be seen that when polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate are mixed in a specific ratio, the bending modulus of the composite material is obviously reduced, which indicates whether the prepared fluff is soft or not, and the fluff is more comfortable to use.
After polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate are matched according to a specific proportion, the Vicat softening temperature is above 150 ℃, so that fluff cannot be softened in a disinfection chamber at the temperature of 125 ℃, viruses and bacteria are not easy to wrap in liquid, the disinfection effect is better, and the disinfection is safer.
According to the comparison of the data of the embodiment 2 and the embodiments 3-6 in the table 3, after polyhydroxybutyrate, polylactic acid, polycaprolactone and polybutylene succinate are matched in a specific proportion, the cell acquisition number is increased, probably because the surface roughness of villus is increased, the mucous membrane cells in the oral cavity wall are easier to fall off and adhere to the villus, the sampling efficiency can be effectively improved, the sampling effect is guaranteed, and the accuracy of a later analysis result is guaranteed.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. A degradable disposable sampling oral swab, characterized in that: the sampling device comprises a handle, a connecting rod fixedly connected with the handle and a sampling head arranged on the connecting rod, wherein the sampling head consists of a plurality of villi, one end of the villi is fixedly connected to the connecting rod, and the other end of the villi extends towards the direction far away from the connecting rod;
the fluff comprises the following components in parts by mass:
10-11 parts of polyhydroxybutyrate;
15-16 parts of polylactic acid;
30-32 parts of polycaprolactone;
3-4 parts of polybutylene succinate;
0.1-0.15 part of antioxidant;
the handle and the connecting rod are both made of degradable plastics.
2. A degradable disposable sampling buccal swab as recited in claim 1, wherein: each fluff forms an angle of 88-90 degrees with the tangent plane of the connecting rod at the connecting point of the fluff.
3. A degradable disposable sampling buccal swab as recited in claim 2, wherein: the length of the fluff is 1.9-2.1 mm.
4. A degradable disposable sampling buccal swab as recited in claim 1, wherein: the handle and the connecting rod are both made of polylactic acid.
5. A degradable disposable sampling buccal swab as recited in claim 1, wherein: a breaking section for connecting the handle and the connecting rod is arranged between the handle and the connecting rod, and the breaking section is made of polyhydroxybutyrate.
6. A degradable disposable sampling buccal swab as recited in claim 1, wherein: the fluff is bonded on the connecting section through hot-melt polycaprolactone.
7. A degradable disposable sampling buccal swab as recited in claim 1, wherein: the handle and the connecting rod are both in a circular tube shape.
8. A degradable disposable sampling buccal swab as recited in claim 5, wherein: the break-off section is provided with a mark.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111390477.1A CN114159103B (en) | 2021-11-23 | 2021-11-23 | Degradable disposable sampling oral swab |
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| CN202111390477.1A CN114159103B (en) | 2021-11-23 | 2021-11-23 | Degradable disposable sampling oral swab |
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| CN114159103A true CN114159103A (en) | 2022-03-11 |
| CN114159103B CN114159103B (en) | 2022-09-13 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| CA2298253A1 (en) * | 1999-02-08 | 2000-08-08 | Playtex Products, Inc. | Infrared treated tampon applicators |
| CN207412185U (en) * | 2017-03-14 | 2018-05-29 | 刘海林 | A kind of swab for birds sampling |
| CN108690335A (en) * | 2018-05-30 | 2018-10-23 | 惠州法路源基因科技有限公司 | A kind of sterile sampling swab of environment-friendly type degradable and preparation method thereof |
| CN111647505A (en) * | 2020-06-12 | 2020-09-11 | 上海市刑事科学技术研究院 | DNA (deoxyribonucleic acid) collection swab as well as preparation method and application thereof |
| CN212466051U (en) * | 2020-04-20 | 2021-02-05 | 深圳市第二人民医院 | Flocked throat swab for collection |
| WO2021221817A1 (en) * | 2020-05-01 | 2021-11-04 | President And Fellows Of Harvard College | Sample collection swab |
-
2021
- 2021-11-23 CN CN202111390477.1A patent/CN114159103B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| CA2298253A1 (en) * | 1999-02-08 | 2000-08-08 | Playtex Products, Inc. | Infrared treated tampon applicators |
| CN207412185U (en) * | 2017-03-14 | 2018-05-29 | 刘海林 | A kind of swab for birds sampling |
| CN108690335A (en) * | 2018-05-30 | 2018-10-23 | 惠州法路源基因科技有限公司 | A kind of sterile sampling swab of environment-friendly type degradable and preparation method thereof |
| CN212466051U (en) * | 2020-04-20 | 2021-02-05 | 深圳市第二人民医院 | Flocked throat swab for collection |
| WO2021221817A1 (en) * | 2020-05-01 | 2021-11-04 | President And Fellows Of Harvard College | Sample collection swab |
| CN111647505A (en) * | 2020-06-12 | 2020-09-11 | 上海市刑事科学技术研究院 | DNA (deoxyribonucleic acid) collection swab as well as preparation method and application thereof |
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| CN114159103B (en) | 2022-09-13 |
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Address after: Floor 8, Building 4, No. 128 Shangnan East Road, Huangpu Community, Xinqiao Street, Bao'an District, Shenzhen City, Guangdong Province, 518000 Patentee after: HUACHENYANG (SHENZHEN) TECHNOLOGY Co.,Ltd. Address before: 518000 8th and 11th floors of No.4 factory building, 128 Shangnan East Road, Huangpu Community, Xinqiao street, Bao'an District, Shenzhen City, Guangdong Province Patentee before: HUACHENYANG (SHENZHEN) TECHNOLOGY Co.,Ltd. |