CN114152635A - Equivalent simulation device for neutron energy spectrum in human blood vessel after neutron external irradiation - Google Patents
Equivalent simulation device for neutron energy spectrum in human blood vessel after neutron external irradiation Download PDFInfo
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- 238000001228 spectrum Methods 0.000 title claims abstract description 71
- 238000004088 simulation Methods 0.000 title claims abstract description 63
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 34
- 210000004369 blood Anatomy 0.000 claims abstract description 85
- 239000008280 blood Substances 0.000 claims abstract description 85
- 239000000463 material Substances 0.000 claims description 40
- 238000002139 neutron reflectometry Methods 0.000 claims description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- -1 polyethylene Polymers 0.000 claims description 12
- 239000004698 Polyethylene Substances 0.000 claims description 11
- 229920000573 polyethylene Polymers 0.000 claims description 11
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 239000007832 Na2SO4 Substances 0.000 claims description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 5
- 229910052925 anhydrite Inorganic materials 0.000 claims description 5
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 5
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 5
- 229910017604 nitric acid Inorganic materials 0.000 claims description 5
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 5
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 5
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229910002804 graphite Inorganic materials 0.000 claims description 3
- 239000010439 graphite Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 15
- 230000005855 radiation Effects 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 description 11
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- HGLDOAKPQXAFKI-OUBTZVSYSA-N californium-252 Chemical compound [252Cf] HGLDOAKPQXAFKI-OUBTZVSYSA-N 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229920001155 polypropylene Polymers 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/005—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using neutrons
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T3/00—Measuring neutron radiation
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Abstract
The invention relates to the technical field of nuclear radiation protection, and provides an equivalent simulation device for neutron energy spectrum in human blood vessel after neutron external irradiation, wherein after the equivalent simulation device receives neutron beam irradiation, the neutron energy spectrum finally formed by scattering and moderating incident neutrons in the equivalent simulation device is similar to the neutron energy spectrum in human model blood vessel irradiated by a neutron field in space in shape, so that the equivalent simulation device can be used for completing neutron energy spectrum in human blood24Calculating the specific activity of Na; the technical effects of reducing engineering difficulty and cost and improving the irradiation efficiency on blood are achieved.
Description
Technical Field
The invention relates to the technical field of nuclear radiation protection, in particular to an equivalent simulation device of neutron energy spectrum in a human blood vessel after neutron external irradiation.
Background
In nuclear explosions and accidents, external neutron irradiation is an important source of human radiation. Therefore, after personnel are irradiated by nuclear radiation, the neutron external irradiation dose is timely and accurately evaluated, and the method has important value for medical treatment of wounded personnel and evaluation of accident hazard degree.
The dose evaluation method for measuring the induced radioactivity generated after the human body is irradiated by neutrons is called a neutron activation method, and is an external irradiation dose evaluation method with neutron specificity. Specifically, when a person is irradiated with neutron rays, neutrons will interact with the neutrons in the human body23Na element generates radiation capture reaction to generate radionuclide24Na by measuring in blood samples of irradiated persons24The specific activity of Na can be used for estimating the neutron external irradiation dose. The neutron activation method has the advantages of convenient sample acquisition, short measurement time and capability of performing rapid dose evaluation on an accident site.
However, in the process of external irradiation dose evaluation, the neutron external irradiation experiment cannot be directly carried out by using a human body, and the irradiation needs to be replaced by a human body model which is consistent and standard with the structure, density and element composition of a real human body; however, the current human body models for irradiation experiments, such as simplified human body digital models BOMB and MIRD provided by the International Commission on radiological protection (ICRP), do not give the distribution of blood vessels and blood of the human body; other complex digital models such as the U.S. VIP-Man, German GFS, Chinese CNMAN and the like only depict main artery and vein blood vessels of a human body and do not consider the detailed distribution condition of the blood vessels. Therefore, it is not suitable for the neutron activation method to calculate the blood level of human body24In the context of the conversion coefficient of Na specific activity to neutron external irradiation dose.
If the mode of a physical model of the human body is adopted for carrying out the blood treatment on the human body24The calculation of the conversion coefficient from Na specific activity to neutron external irradiation dose has the following disadvantages:
1) because the distribution of human blood vessels, especially capillary blood vessels is complex, the problems of great difficulty and high cost are faced if a human physical model containing accurate human blood vessels and blood distribution is manufactured; 2) because the neutron beam current of large-scale neutron irradiation devices such as reactors and spallation neutron sources is generally linear, the neutron irradiation devices are not suitable for irradiating the whole body of a physical model of a human body; in order to uniformly irradiate a human physical model, a neutron field with higher fluence and good uniformity needs to be provided in a sufficient three-dimensional space, the difficulty in maintaining the uniformity of the neutron field in a large space is high, and few experimental platforms capable of providing the high-quality space neutron field are provided; 3) the blood is distributed at each part of the whole body but only accounts for 7-8% of the mass of the human body, when the physical model of the human body is irradiated by the neutron field in the space, the neutron fluence which can reach the blood is less due to the effects of scattering, moderation, absorption and the like of neutrons and human tissue organs, namely the irradiation efficiency of the blood in the phantom is lower.
Therefore, an equivalent simulation device for measuring the neutron energy spectrum in the human blood vessel after external neutron irradiation with high efficiency is needed.
Disclosure of Invention
The invention provides an equivalent simulation device for neutron energy spectrum in human blood vessel after neutron external irradiation, which is used for performing neutron energy spectrum in human blood24The calculation of the specific activity of Na has the technical effects of simple structure, easy processing and good simulation effect.
In order to achieve the purpose, the equivalent simulation device for the neutron energy spectrum in the human body blood vessel after neutron external irradiation is in a box-shaped container structure receiving the neutron external irradiation, and the relative error between the neutron energy spectrum in the equivalent simulation device after the neutron external irradiation and the normalized intensity of the corresponding energy point of the neutron energy spectrum in the blood vessel of the human body digital model after the neutron external irradiation is less than 5%;
the box-shaped container structure comprises a tissue simulation part and a neutron reflection part which are sequentially arranged from near to far along the direction of neutron beam current; the tissue simulation part comprises a front side wall, a rear side wall, a left side wall, a right side wall, an upper side wall, a lower side wall and an equivalent tissue material cavity enclosed by the side walls; the equivalent tissue material cavity is a closed cavity used for filling equivalent tissue material simulating human tissue; wherein,
the side wall which receives neutron beam irradiation at first is a front side wall, and a blood sample part is arranged on a rear side wall; forming a blood sample chamber filled with a blood sample simulating human blood in the blood sample portion;
the neutron reflection part is used for reflecting neutrons which pass through the equivalent tissue part and the blood sample part and reach the neutron reflection part to the blood sample part.
Further, it is preferable that the neutron reflection section is a solid body of polyethylene or a closed chamber filled with a neutron reflection material other than polyethylene.
Further, it is preferable that the neutron reflecting material other than polyethylene is one of water, paraffin, or graphite.
Further, preferably, the tissue simulation part is a cuboid with the length of 17.1cm, the width of 38cm and the height of 23cm, and the long side of the tissue simulation part is parallel to the neutron beam direction; the thickness of the front side wall is 2.2cm, and the thickness of the side walls except the front side wall is 3 cm;
the neutron reflection part is a cuboid with the length of 12.9cm, the width of 38cm and the height of 23 cm; the long side of the neutron reflection part is parallel to the neutron beam direction;
the blood sample part is a cuboid with the length of 5.2cm, the width of 5.2cm and the thickness of 4mm, and the distance between the bottom of the blood sample part and the bottom surface of the equivalent tissue material cavity is 6.2 cm; the thick side of the blood sample part is parallel to the long side of the tissue simulation part, and the thickness of the blood sample part is 1 mm.
Further, it is preferable that the tissue simulation part and the neutron reflection part are each formed to have a density of 0.96g/cm3The polyethylene member of (1); the blood sample part has a density of 1.15g/cm3The polymethyl methacrylate member of (1).
Further, preferably, the equivalent structure material is H2O、C2H6O、NH4NO3、Ca(NO3)2、Ca(H2PO4)2、K2SO4、HNO3、Na2SO4、CaSO4A mixed solution of NaCl and MgCl; h2O、C2H6O、NH4NO3、Ca(NO3)2、Ca(H2PO4)2、K2SO4、HNO3、Na2SO4、CaSO4And the mass ratio of NaCl to MgCl is respectively as follows: 49.076%: 34.432%: 5.626%: 5.231%: 3.721%: 0.768%: 0.411%: 0.304%: 0.185%: 0.125%: 0.121 percent.
Further, preferably, the incident position of the neutron beam is 7cm higher than the bottom surface of the tissue simulation part, and when the beam spot radius of the neutron beam is 1cm, the bottom of the blood sample part is 2.2cm above the center of the beam spot of the neutron beam.
By establishing the equivalent simulation device of neutron energy spectrum in human blood vessel after external neutron irradiation with simple structure, the neutron energy spectrum finally formed by scattering and moderating incident neutrons in the equivalent simulation device after receiving neutron beam irradiation is similar to the neutron energy spectrum in human model blood vessel irradiated by a space neutron field in shape, so the neutron energy spectrum can be used for completing the neutron energy spectrum in human blood24The calculation of Na specific activity has the following beneficial effects:
1) the human physical model containing accurate human blood vessel and blood distribution is not required to be manufactured, so that the detection engineering quantity and the detection cost are greatly reduced;
2) by utilizing the equivalent simulation device, on the premise that the neutron energy spectrum of the blood sample after external neutron irradiation is the same as the neutron energy spectrum in the human blood vessel after external neutron irradiation, the neutron fluence of the blood sample is far higher than that in the blood vessel when the human model is irradiated, so that the technical effect of greatly improving the irradiation efficiency is achieved;
3) different from a space neutron field required by a physical model of a human body, the irradiation requirement can be met only by adopting linear neutron beam, so that the experimental condition is easier to meet.
Drawings
Fig. 1 is a schematic structural diagram of an equivalent simulation apparatus for neutron energy spectrum in a human blood vessel after neutron external irradiation according to an embodiment of the present invention;
fig. 2 is a power spectrum of an incident neutron beam provided in an embodiment of the present invention;
FIG. 3 is a comparison graph of the neutron energy spectrum in the human physical model vessel and the neutron energy spectrum in the equivalent simulation device according to an embodiment of the present invention;
wherein, 1, the tissue simulation part; 2. equivalent tissue material; 3. a blood sample portion; 4. a blood sample; 5. a neutron reflection unit;
the implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an equivalent simulation apparatus for neutron energy spectrum in a human body vessel after neutron external irradiation according to an embodiment of the present invention.
Example 1
The equivalent simulation device is a box-shaped container structure which receives external irradiation of neutrons, and the box-shaped container structure comprises a tissue simulation part 1 and a neutron reflection part 5 which are sequentially arranged from near to far along the direction of neutron beam; the tissue simulation part 1 comprises a front side wall, a rear side wall, a left side wall, a right side wall, an upper side wall, a lower side wall and an equivalent tissue material cavity enclosed by the side walls; the equivalent tissue material cavity is a closed cavity for filling an equivalent tissue material 2 simulating human tissue; when the beam spot radius of the neutron beam is 1cm, the side wall which is firstly irradiated by the neutron beam is a front side wall, and a blood sample part 3 is arranged on the rear side wall; the bottom of the blood sample part 3 is positioned 2.2cm above the center of the beam spot of the neutron beam, so that the excessive high-energy neutrons reaching the blood sample part 3 caused by the direct irradiation of the neutron beam on the blood sample part are avoided; a blood sample chamber filled with a blood sample 4 simulating human blood is formed in the blood sample portion 3; the neutron reflection unit 5 is configured to reflect neutrons that have reached the neutron reflection unit 5 through the equivalent tissue unit and the blood sample unit to the blood sample unit 3. It should be noted that the device achieves the technical effect of avoiding excessive high-energy neutrons reaching the blood sample part due to the fact that the neutron beam directly irradiates the sample. Because the farther the neutron beam is from the sample, the more severe the neutron moderation scattering is, the less the high-energy neutron proportion is, and when the bottom of the blood sample part 3 is located 2.2cm above the center of the beam spot of the neutron beam, the optimal position for the simulation calculation is obtained, and the neutron spectrum in the position is closest to the spectrum in the real blood vessel.
That is, the equivalent simulation device is mainly composed of a box-like container structure and the equivalent tissue material 2 and neutron reflection material in the container. Wherein, along the direction of neutron beam incidence, the neutron reflecting materialLocated behind the equivalent tissue material 2. The neutron reflection part 5 is a polyethylene solid body with the length of 12.9cm, the width of 38cm and the height of 23cm, and is made of material with the density of 0.96g/cm3(ii) a As shown in fig. 1, the length direction of the neutron reflection unit 5 is the direction of the X axis; the equivalent tissue material 2 is placed in an equivalent tissue material chamber of the tissue simulation part 1, and the external dimensions of the tissue simulation part 1 are 17.1cm in length, 38cm in width and 23cm in height; the material has a density of 0.96g/cm3The polyethylene of (a); the side wall closest to the injection of the neutron beam is a front side wall, the thickness of the front side wall is 2.2cm, and the thickness of the other five surfaces is 3 cm; as shown in FIG. 1, the longitudinal direction of the tissue simulator 1 is the direction of the X-axis. The equivalent tissue material 2 is positioned in the equivalent tissue material chamber, the geometric dimensions of the equivalent tissue material 2 are 11.9cm in length, 32cm in width and 17cm in height, the equivalent tissue material 2 is an alcohol mixed solution of various inorganic salts, and the equivalent tissue material is weakly acidic and Ca (H)2PO4)2The solubility is higher in a weak acid environment, no precipitation occurs, the material of the equivalent tissue material 2 simulates the main element composition of a human body, and the density is 1.05g/cm3The elemental composition is shown in Table 1, and the chemical composition is shown in Table 2.
TABLE 1 elemental composition of equivalent structure Material 2
TABLE 2 chemical composition of equivalent tissue material 2
| Composition (I) | H2O | C2H6O | NH4NO3 | Ca(NO3)2 | Ca(H2PO4)2 | K2SO4 | HNO3 | Na2SO4 | CaSO4 | NaCl | MgCl |
| Mass ratio% | 49.076 | 34.432 | 5.626 | 5.231 | 3.721 | 0.768 | 0.411 | 0.304 | 0.185 | 0.125 | 0.121 |
The blood sample 4 is contained in a blood sample chamber of the blood sample part 3, the blood sample part is a cuboid with a length of 5.2cm, a width of 5.2cm and a thickness of 4mm, and the bottom of the blood sample part and the chamber of the equivalent tissue materialThe distance of the bottom surface of (a) is 6.2 cm; the thickness of the wall of the blood sample part is 1mm, namely the blood sample part can hold a blood sample with the volume of 5cm multiplied by 2 mm. As shown in fig. 1, the thickness direction of the blood sample portion 3 is parallel to the X-axis direction. The blood sample 4 had a length of 5cm, a width of 5cm, a thickness of 2mm and a density of 1.06g/cm3The elemental composition is shown in Table 3; the blood sample part 3 is a blood sample container, and the blood sample part 3 is an organic glass (polymethyl methacrylate) container with a wall thickness of 1mm and a density of 1.15g/cm3. The blood sample part 3 is tightly attached to the rear side wall of the equivalent tissue material chamber, and the distance between the bottom surface of the blood sample part 3 and the outer bottom surface of the equivalent simulation device is 9.2 cm.
The components of the blood sample 4 are specifically set according to the detection result of the blood components in the actual scene. The blood sample can be real human blood, can be replaced by sodium chloride solution with the same sodium content as blood, and can also be formed by other chemical reagents with the same component as blood elements, and the mixture ratio is not limited specifically here. In this example, a blood sample was taken from human blood, the elemental composition of which is shown in Table 3.
TABLE 3 elemental composition of blood sample 4
Neutron beam is emitted at a position 7cm away from the bottom of the equivalent simulation device, and the radius of a beam spot of the beam is 1 cm. The energy spectrum of the incident neutron beam is shown in fig. 2, which is the watt fission spectrum of californium-252, the horizontal axis represents the neutron energy, and the vertical axis represents the normalized intensity, i.e., when the total emission probability is 1, the emission probability of neutrons with different energies is obtained.
Neutrons reach the blood sample 4 after being moderated and scattered by the side wall of the tissue simulation part 1 and the equivalent tissue material 2; part of neutrons are reflected by the neutron reflecting part to reach the blood sample 4 after passing through the side wall of the tissue simulation part 1 and the equivalent tissue material 2, and a neutron energy spectrum I in the blood sample 4 is obtained through Monte Carlo simulation calculation, wherein the neutron energy spectrum I is a neutron energy spectrum in the equivalent simulation device.
The obtained neutron spectrum is compared with a pre-obtained reference neutron spectrum, and the comparison result is shown in fig. 3.
The acquisition method of the reference neutron energy spectrum comprises the following steps: irradiating a human digital model containing main blood vessels of a human body outside a uniform neutron field; and calculating the neutron energy spectrum in the phantom blood vessel when the californium-252 neutron source uniformly irradiates the human body digital model on the front surface through Monte Carlo simulation, namely the reference neutron energy spectrum. The human body digital model containing the main blood vessels of the human body is a human body digital model constructed according to the human body tissue and organ data given in the ICRP110 publication. The reference spectrum is the neutron spectrum in the human model blood vessel.
FIG. 3 shows a comparison of neutron energy spectrum in a human physical model vessel with neutron energy spectrum in an equivalent simulation apparatus; by observing fig. 3, it is found that the neutron energy spectrum in the equivalent simulation device is similar to the neutron energy spectrum in the human model blood vessel in shape, but the intensity of the neutron energy spectrum in the equivalent simulation device is 109 times of the neutron energy spectrum in the human model blood vessel, and the fluctuation (relative error) of the ratio obtained by dividing the normalized intensity of the corresponding energy points of the two energy spectra is less than 5%.
Example 2
The neutron reflection part 5 is a closed chamber which is filled with a neutron reflection material, and the neutron reflection material is one of water, paraffin or graphite except polyethylene; the material of the container body of the equivalent simulation device is 0.96g/cm in density3The polypropylene of (1). The other experimental conditions are the same as those in the embodiment 1, an equivalent simulation device of the neutron energy spectrum in the human blood vessel after neutron external irradiation is established, and a neutron energy spectrum II in the blood sample 4 is obtained through Monte Carlo simulation calculation.
Comparing the second neutron energy spectrum with the reference energy spectrum, finding that the shapes of the second neutron energy spectrum and the reference energy spectrum are similar, the intensity of the neutron energy spectrum in the equivalent simulation device is 109 times of the neutron energy spectrum in the human model blood vessel, and the fluctuation (relative error) of the ratio obtained by dividing the normalized intensity of the energy points corresponding to the two energy spectra is less than 5%.
The equivalent simulation device for neutron energy spectrum in human blood vessel after external neutron irradiation provided by the invention has the advantages that after the neutron beam irradiation is received, incident neutrons are in the equivalent simulation deviceThe neutron energy spectrum finally formed by internal scattering and moderation is similar to the neutron energy spectrum shape in the human body model blood vessel irradiated by the space neutron field, so that the neutron energy spectrum can be used for completing the neutron energy spectrum shape in the human body blood24Calculating the specific activity of Na; the method has the characteristics that a human physical model containing accurate human blood vessels and blood distribution does not need to be manufactured, so that the detection engineering quantity and the detection cost are greatly reduced; by utilizing the equivalent simulation device, on the premise that the neutron energy spectrum of the blood sample after external neutron irradiation is the same as the neutron energy spectrum in the human blood vessel after external neutron irradiation, the neutron fluence of the blood sample is far higher than that in the blood vessel when the human model is irradiated, so that the technical effect of greatly improving the irradiation efficiency is achieved; different from a space neutron field required by a physical model of a human body, the irradiation requirement can be met only by adopting linear neutron beam, and the technical effect that experimental conditions are easier to meet is achieved.
Finally, it should be noted that the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. An equivalent simulation device of neutron energy spectrum in a human blood vessel after neutron external irradiation is characterized in that,
the equivalent simulation device is of a box-shaped container structure which receives neutron external irradiation, and the relative error between the neutron energy spectrum in the equivalent simulation device after the neutron external irradiation and the normalized intensity of the corresponding energy point of the intravascular neutron energy spectrum of the digital human body model after the neutron external irradiation is less than 5%;
the box-shaped container structure comprises a tissue simulation part and a neutron reflection part which are sequentially arranged from near to far along the direction of neutron beam current; the tissue simulation part comprises a front side wall, a rear side wall, a left side wall, a right side wall, an upper side wall, a lower side wall and an equivalent tissue material cavity enclosed by the side walls; the equivalent tissue material cavity is a closed cavity for filling equivalent tissue material simulating human tissue; wherein,
the side wall which receives neutron beam irradiation at first is a front side wall, and a blood sample part is arranged on the rear side wall; forming a blood sample chamber filled with a blood sample simulating human blood in the blood sample portion;
the neutron reflection part is used for reflecting neutrons which pass through the equivalent tissue part and the blood sample part and reach the neutron reflection part to the blood sample part.
2. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 1,
the neutron reflection part is a polyethylene solid body or a closed cavity filled with a neutron reflection material except polyethylene.
3. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 2,
the neutron reflecting material except polyethylene is one of water, paraffin or graphite.
4. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 1,
the tissue simulation part is a cuboid with the length of 17.1cm, the width of 38cm and the height of 23cm, and the long side of the tissue simulation part is parallel to the neutron beam direction; the thickness of the front side wall is 2.2cm, and the thickness of the side walls except the front side wall is 3 cm;
the neutron reflection part is a cuboid with the length of 12.9cm, the width of 38cm and the height of 23 cm; the long side of the neutron reflection part is parallel to the neutron beam direction;
the blood sample part is a cuboid with the length of 5.2cm, the width of 5.2cm and the thickness of 4mm, and the distance between the bottom of the blood sample part and the bottom surface of the equivalent tissue material cavity is 6.2 cm; the thick edge of the blood sample part is parallel to the long edge of the tissue simulation part, and the wall thickness of the blood sample part is 1 mm.
5. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 4, wherein the tissue simulation part and the neutron reflection part are both at a density of 0.96g/cm3The polyethylene member of (1); the blood sample part has a density of 1.15g/cm3The polymethyl methacrylate member of (1).
6. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 1,
the equivalent tissue material is H2O、C2H6O、NH4NO3、Ca(NO3)2、Ca(H2PO4)2、K2SO4、HNO3、Na2SO4、CaSO4A mixed solution of NaCl and MgCl;
said H2O、C2H6O、NH4NO3、Ca(NO3)2、Ca(H2PO4)2、K2SO4、HNO3、Na2SO4、CaSO4And the mass ratio of NaCl to MgCl is respectively as follows: 49.076%: 34.432%: 5.626%: 5.231%: 3.721%: 0.768%: 0.411%: 0.304%: 0.185%: 0.125%: 0.121 percent.
7. The apparatus for equivalent simulation of neutron energy spectrum in a human vessel after external neutron irradiation of claim 1,
the incident position of the neutron beam is 7cm higher than the bottom surface of the tissue simulation part; and,
when the radius of the beam spot of the neutron beam is 1cm, the bottom of the blood sample part is positioned 2.2cm above the center of the beam spot of the neutron beam.
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