CN114129631A - Comprehensive regulation intervention medicament, device and method for resisting depression by aromatherapy - Google Patents

Comprehensive regulation intervention medicament, device and method for resisting depression by aromatherapy Download PDF

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CN114129631A
CN114129631A CN202111453914.XA CN202111453914A CN114129631A CN 114129631 A CN114129631 A CN 114129631A CN 202111453914 A CN202111453914 A CN 202111453914A CN 114129631 A CN114129631 A CN 114129631A
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CN114129631B (en
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左秀芹
左秀利
左鑫
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Hebei Taicheng Agricultural Science And Technology Development Co ltd
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Hebei Taicheng Agricultural Science And Technology Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/24Antidepressants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0077Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of chemical or pharmacological stimulus

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Abstract

The invention discloses a comprehensive regulation intervention medicament, a device and a method for resisting depression by aromatherapy, wherein the intervention medicament comprises rosa damascena, sandalwood, lemon, ethanol and deionized water. The invention relates to the field of medicament formula and using equipment, in particular to a comprehensive regulation intervention medicament, a device and a method for resisting depression by aromatherapy. The invention aims to provide a comprehensive regulation intervention medicament, a device and a method for resisting depression by aromatherapy, which are convenient for preparation and use of the aromatherapy intervention medicament.

Description

Comprehensive regulation intervention medicament, device and method for resisting depression by aromatherapy
Technical Field
The invention relates to the field of medicament formula and using equipment, in particular to a comprehensive regulation intervention medicament, a device and a method for resisting depression by aromatherapy.
Background
According to the world health organization's definition of "health" is the state of well-being of physical, psychological, social adaptation. Among them, mental health is an important component of health. In the growth and development process of a human, mental health is a sound state of reasonable cognition, stable emotion, proper behavior, interpersonal harmony and adaptation change in the growth and development process of the human, and is an important component of health. China is in the social transformation stage, social competition is continuously aggravated, life rhythm is accelerated, various psychological stress factors are increased rapidly, and psychological health problems such as depression and anxiety are increasingly prominent.
As a common mental disease, depression is the second largest killer of adults, the number of depression patients in the world reaches 3.5 hundred million according to the data of the world health organization 2020, and the number of depression patients in China exceeds 9500 million. Therefore, there is a great need to augment early intervention in patients with psychiatric disorders, particularly depression. In addition, the opinion of healthy chinese actions indicates that the mental health of the elderly needs to be of great concern. The old people have the problems of decline of functions and successive occurrence of various somatic diseases along with organ aging, and are more prone to various mental disorders and mental health problems, most common of which are depression, anxiety, sleep disorder and the like. The observation also indicates that the mental health of various chronic disease patients needs to pay attention in addition to the elderly population, particularly cancer patients often have emotional problems such as depression, anxiety, fear and the like due to long-term physiological and psychological consumption. Mental problems of mental diseases (particularly depression), old people and cancer patients need to be paid attention to and corresponding intervention measures are taken.
The intervention measures for emotional disorders such as depression and psychological problems mainly comprise two categories of drug treatment and non-drug intervention at present, and the side effects of the drug treatment are large and are difficult to accept by many patients. In non-drug intervention, psychotherapy requires professional psychotherapists, has the defects of long treatment time, high cost and the like, so that the patient acceptance is low and the application effect is poor. Music therapy and exercise therapy are also subject to a number of factors including the site, equipment, and patient condition, and there is a future need to explore other simpler and more feasible intervention programs.
Aromatherapy works by massaging, bathing and inhaling essential oils extracted from aromatic herbs, stimulating olfactory receptor cells, which are then transmitted to the limbic system to produce positive effects to reduce psychological disorders and increase well-being. In recent years, aromatherapy, as an emerging intervention method, is gradually applied to clinical practice and is often used for adjuvant therapy of mental diseases such as depression. Recent research also proves that the expression of genes such as the lavender essential oil on hippocampus and amygdala pCREB and c-fos of depressed rats is obviously weakened, and the lavender essential oil has an obvious improvement effect on depression. In addition, aromatherapy has a significant effect on the improvement of negative mood in the elderly. According to the systematic evaluation of Cochrane cooperative network in 2020, the fragrance method can effectively improve the sleep disorder and depressed mood of the old. Multiple studies show that aromatherapy also has an improving effect on cognitive functions of patients with senile dementia, can promote memory function reconstruction and reduce cognitive disorder symptoms, and can be applied to early intervention of senile dementia. Except for the elderly, studies have shown that aromatherapy can promote physical and mental recovery and relieve physical symptoms of cancer patients, including sleep, mood, nausea, vomiting, fatigue, pain, edema, constipation, etc. For the psychological problems of cancer patients, aromatherapy can also be alleviated to some extent.
The prior aromatherapy adopts intervention medicaments with poor effect, and no special equipment is used for the aromatherapy intervention medicaments. This is a disadvantage of the prior art.
Disclosure of Invention
The invention aims to provide a comprehensive regulation intervention medicament, a device and a method for resisting depression by aromatherapy, which are convenient for preparation and use of the aromatherapy intervention medicament.
The invention adopts the following technical scheme to realize the purpose of the invention:
an aromatherapy anti-depression complex-regulation intervention medicament, device and method, the intervention medicament comprising Rosa damascena, Santalum album, lemon, ethanol and deionized water.
As a further limitation of the technical solution, according to the content percentage of each component, the rosa damascena is 1% to 3%, the sandalwood is 3% to 10%, the lemon is 2% to 6%, the ethanol is 50% to 80%, and the balance is deionized water.
As a further limitation of the technical solution, the content of the rosa damascena is 1.5%, the content of the sandalwood is 5%, the content of the lemon is 3%, the content of the ethanol is 70%, and the balance of the deionized water is provided.
As a further limitation of the technical solution, the content of the rosa damascena is 2.5%, the content of the sandalwood is 7%, the content of the lemon is 5%, the content of the ethanol is 65%, and the balance of the deionized water is provided.
An aromatherapy anti-depression integrated regulation intervention medicament using device, which comprises a bottom plate, and is characterized in that: the bottom plate is fixedly connected with a box body, a swinging cylinder is arranged in the box body, the box body is fixedly connected with a group of sealing plates corresponding to the swinging cylinder, symmetrical square plates are arranged in the box body, symmetrical round holes II are arranged at the upper part of the box body corresponding to the symmetrical square plates, the box body is rotationally connected with a cover plate, the cover plate is matched with the box body, the cover plate is provided with a group of uniformly distributed round holes I, the box body is fixedly connected with a U-shaped rod, the box body is fixedly connected with symmetrical track grooves, the box body is fixedly connected with a symmetrical round rod V, the box body is fixedly connected with an inclined plate, the inclined plate is fixedly connected with a square rod II, the square rod II is fixedly connected with a symmetrical round rod I, the first round rods are respectively and fixedly connected with a second round ring, the inclined plate is fixedly connected with the second round rod, the second round rod is fixedly connected with a third round rod, and the third round rod is fixedly connected with the first round ring.
As a further limitation of the technical solution, the U-shaped rod is fixedly connected to the motor, the output shaft of the motor passes through the U-shaped rod, the output shaft of the motor is fixedly connected to the L-shaped rod, the round rod of the L-shaped rod is disposed in the sliding groove, the sliding groove is fixedly connected to a rack, the rack is respectively and fixedly connected to symmetric track blocks, each track block is respectively nested in the corresponding track groove, the symmetric rack is respectively engaged with the gear, the symmetric rack is respectively and fixedly connected to the L-plate, the symmetric L-plate is respectively and fixedly connected to the square rod three, the round rod five is respectively and symmetrically passed through the square rod three, the square rod three is respectively and fixedly connected to the vertical rod, the vertical rod is respectively and fixedly connected to the corresponding square plate, the gear is fixedly connected to the round shaft two, the round shaft two passes through the square plate under the box body, the second circular shaft bearing is connected with the first circular ring, the second circular shaft bearing is fixedly connected with the bending rod, and the bending rod is fixedly connected with the fourth circular rod.
As the further limitation of the technical scheme, the two circular rings are symmetrically connected with the third circular shaft in a rotating mode respectively, the three circular shafts are symmetrically connected with the semicircular plates in a fixed mode respectively, the semicircular plates are provided with grooves, the four circular rods are arranged in the grooves, the semicircular plates are fixedly connected with connecting rods, and the connecting rods are fixedly connected with the swing cylinders.
As a further limitation of the technical scheme, the box body bearing is connected with a first round shaft, two ends of the first round shaft are respectively and fixedly connected with a first group of square rods which are uniformly distributed, each square rod corresponds to the box body and is respectively in threaded connection with a jackscrew, each square rod is respectively and fixedly connected with a baffle, and the two groups of baffles are matched and symmetrical with a second round hole.
A method of integrated modulatory intervention of aromatherapy against depression, comprising the steps of:
the method comprises the following steps: performing aromatherapy intervention on a patient, wherein the aromatherapy intervention comprises introduction of aromatherapy, benefits of aromatherapy and a use flow, and a paper version instruction is issued, so that the aromatherapy intervention is convenient to operate and is prevented from being forgotten;
step two: the patient underwent aromatherapy daily at home for 2 interventions 1 time a day for a period of 30min, for a total of 8 weeks.
As a further limitation of the present technical solution, the administration mode: mixing lavender and 0.4ml of intervention medicament, putting the mixture into an intervention medicament using device, and realizing administration through the operation of the intervention medicament using device.
Compared with the prior art, the invention has the advantages and positive effects that:
1. one square plate moves to the middle position, the other square plate moves to the outer side, a sealing plate is arranged below the square plate, a first round hole is formed in the cover plate, a second round hole on one square plate side enters air, and the square plate fans the air with volatilized interference medicament in the middle upwards to be discharged from the first round hole. One square plate moves to the outside, and another square plate moves to the intermediate position, and the round hole two of another square plate gets into the air, and the air fan that has volatile essential oil in the middle moves upwards and discharges, and along with waveing the swing section of thick bamboo, the air is admitted air and is discharged the atmospheric pressure balance, and has realized that the middle has the air of volatile essential oil to continue, intermittent type nature upwards discharges.
2. The top screw is unscrewed, the square rod I is swung, the round shaft I is rotated, the baffle is matched with the round hole II, and the top screw is screwed down. Different baffles shield the round holes II with different areas, so that the air quantity entering the box body from the round holes II is different, and intervention on the control of the medicament discharge speed and quantity is realized.
3. The device is skillfully designed, so that the essential oil is discharged, and the discharge speed and the quantity of the essential oil are adjusted.
Drawings
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a partial perspective view of the first embodiment of the present invention.
Fig. 3 is a partially cut-away perspective view of the first embodiment of the present invention.
Fig. 4 is a partial perspective view of the second embodiment of the present invention.
Fig. 5 is a schematic view of a partial three-dimensional structure of the present invention.
Fig. 6 is a partial perspective view illustrating a fourth embodiment of the present invention.
Fig. 7 is a schematic diagram of a partially cut-away perspective structure of the present invention.
Fig. 8 is a schematic perspective view of the second embodiment of the present invention.
In the figure: 1. the box body comprises a cover plate, 2, a first round hole, 3, a box body, 4, a second round hole, 5, a bottom plate, 6, a baffle plate, 7, a first square rod, 8, a jackscrew, 9, a first round shaft, 10, a sealing plate, 11, a track groove, 12, a U-shaped rod, 13, an L plate, 14, a track block, 15, a rack, 16, an L-shaped rod, 17, a motor, 18, a sliding groove, 19, a swinging cylinder, 20, a connecting rod, 21, a first round rod, 22, a second square rod, 23, a sloping plate, 24, a second round rod, 25, a third round rod, 26, a second round shaft, 27, a first round ring, 28, a bent rod, 29, a fourth round rod, 30, a groove, 31, a semicircular plate, 32, a second round ring, 33, a third round shaft, 34, a square plate, 35, a vertical rod, 36, a fifth round rod, 37, a third square rod, 38 and a gear.
Detailed Description
An embodiment of the present invention will be described in detail below with reference to the accompanying drawings, but it should be understood that the scope of the present invention is not limited to the embodiment.
The intervention medicament comprises Damascus rose, sandalwood, lemon, ethanol and deionized water.
According to the content percentage of each component, the Damascus rose accounts for 1-3%, the sandalwood accounts for 3-10%, the lemon accounts for 2-6%, the ethanol accounts for 50-80%, and the balance is deionized water.
The first embodiment is as follows: 1.5% of rosa damascena, 5% of sandalwood, 3% of lemon, 70% of ethanol and the balance of deionized water.
Example two: the rose damascus accounts for 2.5%, the sandalwood accounts for 7%, the lemon accounts for 5%, the ethanol accounts for 65%, and the balance of deionized water.
Example three: an aromatherapy anti-depression comprehensive regulation intervention medicament using device comprises a bottom plate 5, wherein the bottom plate 5 is fixedly connected with a box body 3, a swinging cylinder 19 is arranged in the box body 3, the box body 3 is fixedly connected with a group of sealing plates 10 corresponding to the swinging cylinder 19, symmetrical square plates 34 are arranged in the box body 3, symmetrical round holes II 4 are arranged on the square plates 34 corresponding to the upper part of the box body 3, the box body 3 is rotatably connected with a cover plate 1, the cover plate 1 is matched with the box body 3, the cover plate 1 is provided with a group of evenly distributed round holes I2, the box body 3 is fixedly connected with a U-shaped rod 12, the box body 3 is fixedly connected with symmetrical track grooves 11, the box body 3 is fixedly connected with symmetrical round rods V36, the box body 3 is fixedly connected with an inclined plate 23, the inclined plate 23 is fixedly connected with a square rod II 22, the square rod II 22 is fixedly connected with a symmetrical round rod I21, the first symmetrical round rods 21 are fixedly connected with the second round rings 32 respectively, the inclined plate 23 is fixedly connected with the second round rods 24, the second round rods 24 are fixedly connected with the third round rods 25, and the third round rods 25 are fixedly connected with the first round rings 27.
The U-shaped rod 12 is fixedly connected with a motor 17, an output shaft of the motor 17 penetrates through the U-shaped rod 12, an output shaft of the motor 17 is fixedly connected with an L-shaped rod 16, a round rod of the L-shaped rod 16 is arranged in a sliding groove 18, the sliding groove 18 is fixedly connected with a rack 15, the rack 15 is respectively and fixedly connected with symmetrical track blocks 14, each track block 14 is respectively embedded in the corresponding track groove 11, the rack 15 is respectively and symmetrically meshed with a gear 38, the rack 15 is respectively and fixedly connected with an L plate 13, the L plate 13 is respectively and fixedly connected with a square rod three 37, the round rod five 36 is respectively and symmetrically penetrated through the square rod three 37, the square rod three 37 is respectively and fixedly connected with a vertical rod 35, the vertical rod 35 is respectively and fixedly connected with the corresponding square plate 34, and the gear 38 is fixedly connected with a round shaft two 26, the second round shaft 26 penetrates through the lower side square plate of the box body 3, the second round shaft 26 is in bearing connection with the first round ring 27, the second round shaft 26 is fixedly connected with a bending rod 28, and the bending rod 28 is fixedly connected with a fourth round rod 29.
The symmetry two 32 of ring rotate respectively and connect three 33 of circle axle, the symmetry three 33 of circle axle fixed connection semicircle board 31 respectively, semicircle board 31 is provided with recess 30, four 29 settings of round bar are in the recess 30, semicircle board 31 fixed connection connecting rod 20, connecting rod 20 fixed connection swing section of thick bamboo 19.
The cover plate 1 is opened and the intervention drug or the like is put into the swing cylinder 19. The opening motor 17 drives the L-shaped rod 16 to swing, meanwhile, the round rod of the L-shaped rod 16 moves along the sliding groove 18, the L-shaped rod 16 drives the sliding groove 18 to reciprocate, the sliding groove 18 drives one rack 15 to reciprocate, one rack 15 drives the gear 38 to reciprocate, the gear 38 drives the other rack 15 to reciprocate, the rack 15 drives the track block 14 to reciprocate along the track groove 11, the rack 15 drives the L plate 13 to reciprocate, the L plate 13 drives the square rod three 37 to reciprocate along the round rod five 36, the square rod three 37 drives the vertical rod 35 to reciprocate, and the vertical rod 35 drives the square plate 34 to reciprocate. The gear 38 drives the second circular shaft 26 to rotate in a reciprocating manner, the second circular shaft 26 drives the bending rod 28 to swing in a reciprocating manner, the bending rod 28 drives the fourth circular rod 29 to swing in the groove 30 in a reciprocating manner, the fourth circular rod 29 drives the semicircular plate 31 to swing in a reciprocating manner, the semicircular plate 31 drives the third circular shaft 33 to rotate in a reciprocating manner, the semicircular plate 31 drives the connecting rod 20 to swing in a reciprocating manner, and the connecting rod 20 drives the swing cylinder 19 to swing in a reciprocating manner.
One square plate 34 moves to the middle position, the other square plate 34 moves to the outer side, a sealing plate 10 is arranged below the other square plate, a first round hole 2 is formed in the cover plate 1, air enters from a second round hole 4 on the side of the one square plate 34, and the square plate 34 blows air with volatilized interference medicament in the middle upwards to be discharged from the first round hole 2. One square plate 34 moves outwards, the other square plate 34 moves towards the middle position, the round hole two 4 of the other square plate 34 enters air, the air with the volatilized essential oil in the middle is discharged upwards in a fanning mode, the air inlet and exhaust air pressure is balanced along with the swinging of the swinging cylinder 19, and the continuous and intermittent upwards discharge of the air with the volatilized essential oil in the middle is realized.
Example four: the embodiment is further explained on the basis of the third embodiment, the first round shaft 9 is connected with the bearing of the first box body 3, the first square rod 7 which is uniformly distributed is fixedly connected to the two ends of the first round shaft 9 respectively, each square rod 7 corresponds to the first box body 3 and is in threaded connection with the jackscrew 8 respectively, each square rod 7 is fixedly connected with the baffle 6 respectively, and the baffle 6 is symmetrical in a matching mode with the second round hole 4.
By unscrewing the jackscrew 8, the first square rod 7 is swung, the first round shaft 9 is rotated, the baffle 6 is matched with the second round hole 4, and the jackscrew 8 is screwed down. Different baffles 6 shield the round hole II 4 with different areas, so that the air quantity entering the box body 3 from the round hole II 4 is different, and intervention on the medicament discharge speed and quantity control is realized.
The device is skillfully designed, so that the essential oil is discharged, and the discharge speed and the quantity of the essential oil are adjusted.
A method of integrated modulatory intervention of aromatherapy against depression, comprising the steps of:
the method comprises the following steps: performing aromatherapy intervention on a patient, wherein the aromatherapy intervention comprises introduction of aromatherapy, benefits of aromatherapy and a use flow, and a paper version instruction is issued, so that the aromatherapy intervention is convenient to operate and is prevented from being forgotten;
step two: the patient underwent aromatherapy daily at home for 2 interventions 1 time a day for a period of 30min, for a total of 8 weeks.
The administration mode comprises the following steps: mixing lavender and 0.4ml of intervention medicament, putting the mixture into an intervention medicament using device, and realizing administration through the operation of the intervention medicament using device.
The intervention method is implemented as follows:
(one) carrying out preliminary experiments
5 patients with mild cognitive impairment are selected to carry out pre-experiments of the improved scheme, and the intervention strategy is adjusted again according to the experiment results.
(II) intervention protocol
1. Control group: cognitive disorder-related health education
1.1 intervention content: aromatherapy is carried out by using an essential oil aromatherapy device in which rosemary and lavender are mixed.
1.2 intervention method: in a quiet room of a cognitive outpatient clinic of a general hospital of the liberation force of people in China, the general cognitive nursing education including disease introduction of cognitive disorder, improvement methods of related risk factors, negative emotion relieving strategies and cognitive function related training is performed for patients.
2. Intervention group: aromatherapy and cognitive disorder-related health education
2.1 materials: essential oil fragrance device.
2.2 intervention method: except for carrying out conventional health education on 35 patients with mild cognitive impairment, aromatherapy intervention is carried out on the patients in a quiet room of a cognitive outpatient service in a general hospital of the liberation military of Chinese people, the introduction of aromatherapy, the benefits of aromatherapy and the use flow are included, and a paper version instruction is issued, so that the aromatherapy intervention is convenient to operate and is prevented from being forgotten. Researchers take a follow-up call to patients every month to know the application condition of the patients to aromatic therapy and solve the problems of the patients in the aspects of knowledge and mastery condition of diseases and physical and psychological health. The specific operation method comprises the following steps: aromatherapy is performed at home every day with a daily inhalation duration of 30min, 1 time per day, 2 drops of essential oil each time, for a total of 8 weeks [45 ]. During the treatment period, patients and family members should be advised to observe the adverse reactions of the patients in real time, and should communicate with researchers, adjust or terminate the experimental observation in time if uncomfortable symptoms occur.
2.3 administration mode: mixing lavender and rosemary aroma essential oil 0.4ml, placing in an aroma device, 1 time per day, and treating for 3 weeks.
2.4 site: in a quiet room at the 301 hospital, Beijing.
2.5 reduction of shedding rates in intervention group subjects: establish and keep in touch with the patient, help the patient to establish the confidence of controlling the disease, improving the quality of life, maintain good mental state, establish good relation with the patient. During the intervention period, telephone or WeChat communication with the patient and family members is kept, the patient is reminded to complete family work on time, and the patient is encouraged to insist on completing the intervention activity.
3. Evaluation of intervention Effect
Subjects data was collected at 3 time points and the patients' daily living abilities, cognitive functions, depressive status, and anxiety status were measured. After the intervention was completed, the patients with mild cognitive impairment were measured for their daily living ability, depression and anxiety status, and one month, three months after the intervention was completed, the patients were followed up and evaluated for their daily living ability, cognitive function, depression and anxiety status.
(III) data analysis method
(1) Statistical description of metrics
1. Age, education age, score of each scale, and the like: for normal distribution data, the data are described by mean ± standard deviation, and are not normal: the median, interquartile range is described.
2. Counting data of sex, occupation, marital status and the like: frequency and percentage are used for description.
(2) Statistical inference of metrics
1. Age, age of education, individual scale scores between groups: statistical inferences were made using independent sample t-test or non-parametric rank-sum test.
2. Differences between groups of scale scores before intervention, dry prognosis, follow-up after 3 months post intervention: statistical inferences were made using the Bonferroni correction method.
3. Counting data of sex, occupation, marital status and the like: statistical inferences were made using the chi-square test.
4. The change trend of the follow-up scale scores before intervention, after intervention and 3 months after intervention is finished: and (5) generalized linear mixed model analysis.
(IV) quality control
1. A preparation stage before intervention: in order to ensure the accuracy of diagnosis of mild cognitive impairment and cognitive function assessment, the use process and the cautionary matters of the screening scale and the cognitive function assessment scale are learned and approved by experts. And performing a pre-experiment, and forming a final intervention scheme according to the pre-experiment result.
2. An intervention stage: the use method of the essential oil humidifying instrument is explained for the patient, and the use instruction is issued to assist the old to finish and make a record, and the examination is carried out after the week. To ensure the quality of the intervention, the investigator briefly summarized the content of each intervention after the training was completed, advocated the patient on a daily basis for aromatherapy, and frequently supervised and encouraged the subject to adhere to the intervention and subsequent follow-up activities.
3. A data collection stage: the data are collected respectively in the screening stage after the intervention is finished; in the data collection process, researchers use a uniform guide to explain filling requirements before filling in a questionnaire; the subject's question set is interpreted. And checking the questionnaire contents one by one, ordering the study objects to fill up if the missing items exist, checking again, and withdrawing.
4. A data entry stage: after the data collection is completed, more than 20% of the missing items are found not to enter the data entry stage. The single-person double-input mode reduces the input error, and the person with logic error checks the original data to correct, checks without error or analyzes after correction.
The above disclosure is only for the specific embodiment of the present invention, but the present invention is not limited thereto, and any variations that can be made by those skilled in the art should fall within the scope of the present invention.

Claims (10)

1. An agent for the integrative regulation intervention of aromatherapy against depression, characterized in that:
the intervention medicament comprises Damascus rose, sandalwood, lemon, ethanol and deionized water.
2. The agent for the integrative regulation of antidepressant according to claim 1, characterized in that: according to the content percentage of each component, the Damascus rose accounts for 1-3%, the sandalwood accounts for 3-10%, the lemon accounts for 2-6%, the ethanol accounts for 50-80%, and the balance is deionized water.
3. The agent for the integrative regulation of antidepressant according to claim 2, characterized in that: 1.5% of rosa damascena, 5% of sandalwood, 3% of lemon, 70% of ethanol and the balance of deionized water.
4. The device for the use of an aromatherapy antidepressant complex-regulating intervention medicament according to claim 2, characterized in that: the rose damascus accounts for 2.5%, the sandalwood accounts for 7%, the lemon accounts for 5%, the ethanol accounts for 65%, and the balance of deionized water.
5. The device for the use of aromatherapy against the comprehensive conditioning of antidepressant interventions according to claim 1, comprising a base plate (5), characterized in that: the bottom plate (5) is fixedly connected with a box body (3), a swing cylinder (19) is arranged in the box body (3), the box body (3) corresponds to the swing cylinder (19) and is fixedly connected with a group of sealing plates (10), symmetrical square plates (34) are arranged in the box body (3), symmetrical round holes two (4) are arranged on the square plates (34) corresponding to the upper part of the box body (3) and are symmetrical, the box body (3) is rotatably connected with a cover plate (1), the cover plate (1) is matched with the box body (3), a group of evenly distributed round holes one (2) are arranged on the cover plate (1), the box body (3) is fixedly connected with a U-shaped rod (12), the box body (3) is fixedly connected with symmetrical track grooves (11), the box body (3) is fixedly connected with a symmetrical round rod five (36), the box body (3) is fixedly connected with an inclined plate (23), and the inclined plate (23) is fixedly connected with a square rod two (22), the square pole two (22) fixed connection symmetrical round pole one (21), the symmetry round pole one (21) is fixed connection ring two (32) respectively, swash plate (23) fixed connection round pole two (24), round pole two (24) fixed connection round pole three (25), round pole three (25) fixed connection ring one (27).
6. The device for the use of an aromatherapy antidepressant complex-regulating intervention medicament according to claim 5, characterized in that: the U-shaped rod (12) is fixedly connected with a motor (17), an output shaft of the motor (17) penetrates through the U-shaped rod (12), an output shaft of the motor (17) is fixedly connected with an L-shaped rod (16), a round rod of the L-shaped rod (16) is arranged in a sliding groove (18), the sliding groove (18) is fixedly connected with a rack (15), the rack (15) is symmetrically and fixedly connected with symmetrical track blocks (14) respectively, each track block (14) is nested in the corresponding track groove (11) respectively, the racks (15) are symmetrically and respectively meshed with a gear (38), the racks (15) are symmetrically and fixedly connected with an L plate (13) respectively, the L plates (13) are symmetrically and fixedly connected with a square rod three (37) respectively, the round rod five (36) is symmetrically and fixedly connected with a square rod three (37) respectively, the square rod three (37) are symmetrically and fixedly connected with a vertical rod (35) respectively, the symmetry montant (35) fixed connection respectively correspond square plate (34), gear (38) fixed connection circle axle two (26), circle axle two (26) are passed box (3) downside square plate, circle axle two (26) bearing is connected ring one (27), circle axle two (26) fixed connection bending rod (28), bending rod (28) fixed connection round bar four (29).
7. The device for the use of an aromatherapy antidepressant complex-regulating intervention medicament according to claim 6, characterized in that: the symmetry two rings (32) rotate respectively and connect circle axle three (33), the symmetry three (33) of circle axle fixed connection semicircle board (31) respectively, semicircle board (31) are provided with recess (30), round bar four (29) set up in recess (30), semicircle board (31) fixed connection connecting rod (20), connecting rod (20) fixed connection swing section of thick bamboo (19).
8. The device for the use of an aromatherapy antidepressant complex-regulating intervention medicament according to claim 5, characterized in that: box (3) bearing connection circle axle one (9), the both ends difference fixed connection square pole one (7) of a set of evenly distributed of circle axle one (9), every square pole one (7) correspond box (3) threaded connection jackscrew (8) respectively, every square pole one (7) are fixed connection baffle (6) respectively, and are two sets of baffle (6) match the symmetry round hole two (4).
9. The method of the complex modulatory intervention of aromatherapy against depression according to claim 1, characterized by the following steps:
the method comprises the following steps: performing aromatherapy intervention on a patient, wherein the aromatherapy intervention comprises introduction of aromatherapy, benefits of aromatherapy and a use flow, and a paper version instruction is issued, so that the aromatherapy intervention is convenient to operate and is prevented from being forgotten;
step two: the patient underwent aromatherapy daily at home for 2 interventions 1 time a day for a period of 30min, for a total of 8 weeks.
10. The method of integrative modulatory intervention of aromatherapy against depression according to claim 9, characterized by: the administration mode comprises the following steps: mixing lavender and 0.4ml of intervention medicament, putting the mixture into an intervention medicament using device, and realizing administration through the operation of the intervention medicament using device.
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