CN114129622A - 一种治疗烧烫伤的组合物、其制剂、制备方法及应用 - Google Patents
一种治疗烧烫伤的组合物、其制剂、制备方法及应用 Download PDFInfo
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Abstract
本发明涉及一种治疗烧烫伤的组合物、其制剂、制备方法及应用，所述的治疗烧烫伤的组合物包括以下原料组分：呋喃唑酮、庆大霉素、蜂蜜、甘草、红花、大黄、冰片。本发明所述的治疗烧烫伤的组合物，原料配伍科学，配比合理，通过各组分协同作用，可收到显著的治疗烧烫伤的效果，本发明用于各种烧、烫、灼伤见效快、愈后不留疤痕，且使用过程清凉舒爽，无刺、辣、灼痛感，免去了患者治疗中的肉体之痛，适用于烧、烫、灼伤的治疗。
Description
技术领域
本发明属于烧烫伤药物技术领域，具体涉及一种治疗烧烫伤的组合物、其制剂、制备方法及应用。
背景技术
烧烫伤是由于热、化学物质、光、电以及放射线等所引起的组织损害，主要指皮肤或黏膜，严重者可伤及皮下组织，如肌肉、骨、关节甚至内脏，是一种极其复杂的外伤性疾病。存在着创面疼痛、进行性坏死、易感染、瘢痕愈合等难题。及时的有效的药物治疗，能够减轻烧伤程度，降低并发症的发生率和死亡率，以及减轻烧烫伤患者的痛苦。
现有的治疗烧烫伤药物较多，但缺少特别有效的药物，且组方不同，药物治疗效果差别较大。另外，现有的药物上药过程大多有较明显的刺、辣、灼痛感，给患者治疗过程带来了极大的痛苦而亟待改善。
发明内容
本发明的目的在于提供一种疗效显著、见效快、愈后不留疤痕、使用过程清凉舒爽，无刺、辣、灼痛感的治疗烧烫伤的组合物，并提供所述组合物的制剂、制备方法及应用。
为实现本发明的上述目的，本发明采用以下技术方案：
本发明提供一种治疗烧烫伤的组合物，包括以下原料组分：呋喃唑酮、庆大霉素、蜂蜜、甘草、红花、大黄、冰片。
根据本发明所述的治疗烧烫伤的组合物，其中，呋喃唑酮为硝基呋喃类抗菌药，其作用机制为干扰细菌氧化还原酶从而阻断细菌的正常代谢。庆大霉素是氨基糖苷类抗生素，可通过不可逆地与30S核糖体相结合，从而抑制敏感菌的蛋白质合成；解毒疗疮，适用于湿疹、皮肤溃烂等。大黄泻下、攻积、清热泻火、凉血解毒、逐瘀通经；外用还能清热、消肿块、疗烫伤，治疗水火烫伤或者烧伤等。蜂蜜味甘、性平，具有止痛、解毒的作用，对汤火烫伤有很好的治疗效果。红花具有活血通经、消肿止痛的作用。冰片味辛、苦，性微寒，归心、脾、肺经，具有开窍醒神，清热解毒的作用，外敷对感觉神经的刺激很轻，而有一定的止疼和温和的防腐作用，较高浓度对金黄色葡萄球菌、白色葡萄球菌、溶血性链球菌、肺炎双球菌有抑制作用。本发明所述的治疗烧烫伤的组合物，各组分协同作用，可收到较好的清热解毒、活血止痛、收湿敛创、祛瘀生新的作用，用于各种烧、烫、灼伤见效快、疗效显著，一般2～7天治愈，愈后不留疤痕，且使用过程清凉舒爽，无刺、辣、灼痛感，免去了患者治疗中的肉体之痛，适用于烧、烫、灼伤的治疗。
根据本发明所述的治疗烧烫伤的组合物，还可通过加入常规药用辅料，按照一般制剂学方法，制备成为适合药用的任何药物剂型，包括但不限于水剂、膏剂、散剂、酊剂、凝胶剂等，优选的，将所述的治疗烧烫伤的组合物制备成为水剂或膏剂。
根据本发明所述的治疗烧烫伤的水剂，包括以下原料组分：呋喃唑酮片 10-15重量份、庆大霉素针剂0.5-0.8重量份、蜂蜜3-5重量份、甘草2-6重量份、红花1-2重量份、大黄7-10重量份、冰片2-6重量份、生理盐水100-200 重量份。所述的水剂的制备方法，包括如下步骤：分别取各原料，备用；将呋喃唑酮片、甘草、红花、大黄、冰片分别研粉后混合，然后加入庆大霉素针剂、生理盐水、蜂蜜，混合均匀，即得。使用方法：药液会有沉淀，每次使用前将药液摇匀，用棉签蘸取后直接涂抹予烫伤烧伤处，创面无需消毒处理。
根据本发明所述的治疗烧烫伤的膏剂，包括以下原料组分：呋喃唑酮片 10-15重量份、庆大霉素片剂10-20重量份、蜂蜜3-5重量份、甘草3-5重量份、红花1-2重量份、大黄7-10重量份、冰片2-6重量份、医用凡士林50-80重量份。所述的膏剂的制备方法，包括如下步骤：分别取各原料，备用；将呋喃唑酮片、庆大霉素片剂、甘草、红花、大黄、冰片分别研粉后混合，然后加入蜂蜜和医用凡士林，混合均匀，即得。使用时，取适量所述的膏剂直接涂敷于烫伤烧伤处即可。
本发明所述的治疗烧烫伤的组合物在制备治疗烧烫伤的药物中的应用。
本发明的有益效果为：
本发明所述的治疗烧烫伤的组合物，一方面，添加了包括呋喃唑酮和庆大霉素在内的抗菌药物，可有效防止创面细菌感染；另一方面，通过采用蜂蜜、甘草、红花、大黄、冰片为原料并进行适合的重量配比，使得所述各组分相互作用，可有效改善外邪郁结成毒，调血合营、行气化滞，使得局部气血畅通，从而创造有利于创面愈合的环境，同时促进创面组织再生，加速创面愈合进程。最终制备得到的组合物，各种组分协同作用，用于各种烧、烫、灼伤见效快、疗效显著、愈后不留疤痕，且使用过程清凉舒爽，无刺、辣、灼痛感，免去了患者治疗中的肉体之痛，适用于烧、烫、灼伤的治疗。
附图说明
图1：病例1治疗前；
图2：病例1治疗后(实施例1药物)；
图3：病例2治疗前；
图4：病例2治疗后(实施例6药物)；
图5：病例3治疗前；
图6：病例3治疗后(实施例3药物)。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
以下实施例中各药品规格如下：庆大霉素针剂(硫酸庆大霉素注射液)： 2ml:80mg(8万单位)；庆大霉素片剂(硫酸庆大霉素片)：40mg/片；呋喃唑酮片：100mg/片。
实施例1
本实施例提供一种治疗烧烫伤的水剂，由以下原料组分制成：
呋喃唑酮片10g、庆大霉素针剂0.8g、蜂蜜3g、甘草6g、红花1g、大黄 10g、冰片2g、生理盐水200g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、甘草、红花、大黄、冰片分别研粉后混合，然后加入庆大霉素针剂、生理盐水、蜂蜜，混合均匀，即得。
实施例2
本实施例提供一种治疗烧烫伤的水剂，由以下原料组分制成：
呋喃唑酮片15g、庆大霉素针剂0.5g、蜂蜜5g、甘草2g、红花2g、大黄 7g、冰片6g、生理盐水100g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、甘草、红花、大黄、冰片分别研粉后混合，然后加入庆大霉素针剂、生理盐水、蜂蜜，混合均匀，即得。
实施例3
本实施例提供一种治疗烧烫伤的水剂，由以下原料组分制成：
呋喃唑酮片12g、庆大霉素针剂0.6g、蜂蜜4g、甘草3g、红花2g、大黄 8g、冰片4g、生理盐水150g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、甘草、红花、大黄、冰片分别研粉后混合，然后加入庆大霉素针剂、生理盐水、蜂蜜，混合均匀，即得。
实施例4
本实施例提供一种治疗烧烫伤的膏剂，由以下原料组分制成：
呋喃唑酮片10g、庆大霉素片剂20g、蜂蜜3g、甘草5g、红花1g、大黄 10g、冰片2g、医用凡士林80g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、庆大霉素片剂、甘草、红花、大黄、冰片分别研粉后混合，然后加入蜂蜜和医用凡士林，混合均匀，即得。
实施例5
本实施例提供一种治疗烧烫伤的膏剂，由以下原料组分制成：
呋喃唑酮片15g、庆大霉素片剂10g、蜂蜜5g、甘草3g、红花2g、大黄 7g、冰片6g、医用凡士林50g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、庆大霉素片剂、甘草、红花、大黄、冰片分别研粉后混合，然后加入蜂蜜和医用凡士林，混合均匀，即得。
实施例6
本实施例提供一种治疗烧烫伤的膏剂，由以下原料组分制成：
呋喃唑酮片12g、庆大霉素片剂15g、蜂蜜4g、甘草4g、红花1g、大黄9g、冰片3g、医用凡士林60g。
所述的治疗烧烫伤的水剂的制备方法为：分别取各原料，备用；将呋喃唑酮片、庆大霉素片剂、甘草、红花、大黄、冰片分别研粉后混合，然后加入蜂蜜和医用凡士林，混合均匀，即得。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。
Claims (8)
1.一种治疗烧烫伤的组合物，其特征在于，包括以下原料组分：
呋喃唑酮、庆大霉素、蜂蜜、甘草、红花、大黄、冰片。
2.根据权利要求1所述的治疗烧烫伤的组合物，其特征在于，所述的治疗烧烫伤的组合物的剂型为适合药用的任何药物剂型。
3.根据权利要求2所述的治疗烧烫伤的组合物，其特征在于，所述的治疗烧烫伤的组合物的剂型为水剂或膏剂。
4.权利要求3所述的治疗烧烫伤的水剂，其特征在于，包括以下原料组分：
呋喃唑酮片10-15重量份、庆大霉素针剂0.5-0.8重量份、蜂蜜3-5重量份、甘草2-6重量份、红花1-2重量份、大黄7-10重量份、冰片2-6重量份、生理盐水100-200重量份。
5.权利要求4所述的治疗烧烫伤的水剂的制备方法，其特征在于，包括如下步骤：分别取各原料，备用；将呋喃唑酮片、甘草、红花、大黄、冰片分别研粉后混合，然后加入庆大霉素针剂、生理盐水、蜂蜜，混合均匀，即得。
6.权利要求3所述的治疗烧烫伤的膏剂，其特征在于，包括以下原料组分：
呋喃唑酮片10-15重量份、庆大霉素片剂10-20重量份、蜂蜜3-5重量份、甘草3-5重量份、红花1-2重量份、大黄7-10重量份、冰片2-6重量份、医用凡士林50-80重量份。
7.权利要求6所述的治疗烧烫伤的水剂的制备方法，其特征在于，包括如下步骤：分别取各原料，备用；将呋喃唑酮片、庆大霉素片剂、甘草、红花、大黄、冰片分别研粉后混合，然后加入蜂蜜和医用凡士林，混合均匀，即得。
8.权利要求1所述的治疗烧烫伤的组合物在制备治疗烧烫伤的药物中的应用。
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