CN114099762A - Production process and application of medical thread capable of being absorbed by human body - Google Patents
Production process and application of medical thread capable of being absorbed by human body Download PDFInfo
- Publication number
- CN114099762A CN114099762A CN202111320494.8A CN202111320494A CN114099762A CN 114099762 A CN114099762 A CN 114099762A CN 202111320494 A CN202111320494 A CN 202111320494A CN 114099762 A CN114099762 A CN 114099762A
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- CN
- China
- Prior art keywords
- casing
- drying
- solution
- chitosan
- thread
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/02—Preparation of spinning solutions
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
- D02G3/10—Yarns or threads formed from collagenous materials, e.g. catgut
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
- D02J3/00—Modifying the surface
- D02J3/02—Modifying the surface by abrading, scraping, scuffing, cutting, or nicking
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a production process and application of a medical thread capable of being absorbed by human body, which comprises the following production steps of material selection, foreign protein removal, virus inactivation, collagen degreasing, casing extension and chitosan atomization: drying, solidifying, crushing, refining, spinning, polishing, gluing and drying; the medical thread produced by the invention has large elasticity, high tensile strength and small creep property, can be absorbed, and the property ensures that the suture thread does not need to be removed by additional operation after a preset time passes after the operation.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a production process and application of a medical wire capable of being absorbed by a human body.
Background
The medical thread (stitch) is a thread for suturing a wound or a damaged part of a human body by an operation or the like. Nylon and silk threads, which are synthetic polymer materials having high physical properties, and alternative materials have been developed and widely used at the beginning of medical lines, but these materials are not decomposable and physiologically compatible in the human body, and thus should be removed by additional surgery after a predetermined time has passed after surgery, and thus there is inconvenience in use and thus limited use.
An effective solution to the problems in the related art has not been proposed yet.
Disclosure of Invention
In order to achieve the above object, the present invention adopts a technical scheme that the present invention provides a production process of a medical thread capable of being absorbed by a body, comprising the following production steps:
(1) selecting materials: selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in edible hydrogen peroxide solution and cleaning;
(4) degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution, and then separating and cutting fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare chitosan saturated solution, uniformly spraying the chitosan saturated solution on the surface of the sausage casing, standing, and repeating the spraying and standing operations for multiple times;
(7) drying and curing: sleeving the sausage casing atomized by chitosan on a drying mould, and drying for 1-2 hours at the temperature of 50-65 ℃; then heating to 70-80 ℃, and drying for 2-4 hours; after drying, adjusting the humidity to be within the range of 40-50%, and demoulding after the temperature of the sausage casing is reduced to room temperature to obtain a dried sausage casing;
(8) crushing: crushing the dried sausage casing into 200 meshes;
(9) refining: refining the crushed sausage casing into a gel, adding acetone and ammonia liquor, and mixing to prepare a spinning solution;
(10) spinning: filtering the spinning solution in the spinning solution by a filter, and spraying 120 silk threads by a spinning pump nozzle; the silk thread bundle is solidified in the solidification liquid and is conveyed to a first twisting device by a silk thread roller to carry out first twisting; the silk threads enter a first cross-linking groove through a godet roller for cross-linking reaction, then enter a first rinsing groove through the godet roller for water washing, and then enter a second twist device for twisting again after the water washing; the godet roller after the second twisting enters a drying box for drying, and then the silk thread is sent into a second cross-linking groove for cross-linking treatment by the godet roller and then enters a second rinsing groove for rinsing; and naturally drying;
(11) polishing and gluing: polishing the naturally dried yarns in the step 10; soaking the wire harness into the glue solution and uniformly extruding;
(12) and drying, namely drying the glued silk thread, and sending the silk thread into a winding roller by a silk guide roller to be wound into a cylindrical finished product.
Preferably, the specific operation of virus inactivation is as follows: soaking the casing with foreign protein removed in 5-7% edible hydrogen peroxide solution at 40-44 deg.C for 13-17 hr, and washing with purified water for 3-5 times.
Preferably, the concentration of the sodium chloride solution in the collagen degreasing process is 14-16%, and the soaking time is 70-78 minutes.
Preferably, the chitosan atomization is specifically operated as: uniformly spraying the chitosan saturated solution with the temperature of 36-48 ℃ on the surface of the sausage casing, standing for 44-56 minutes, then spraying and standing, and repeating the steps for 3-5 times.
Preferably, in the refining process, the weight ratio of acetone to ammonia liquor is 1: 2.3.
has the advantages that: compared with the prior art, the medical thread produced by the invention has the advantages and positive effects that the medical thread has high elasticity, high tensile strength, small creep and absorbability, and the property ensures that the suture thread does not need to be removed by additional operation after a preset time after the operation.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Examples
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the following examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
The scheme provides a production process of a medical line capable of being absorbed by a human body, which comprises the following production steps:
(1) selecting materials: selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in edible hydrogen peroxide solution and cleaning;
(4) degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution, and then separating and cutting fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare chitosan saturated solution, uniformly spraying the chitosan saturated solution on the surface of the sausage casing, standing, and repeating the spraying and standing operations for multiple times;
(7) drying and curing: sleeving the sausage casing atomized by chitosan on a drying mould, and drying for 1-2 hours at the temperature of 50-65 ℃; then heating to 70-80 ℃, and drying for 2-4 hours; after drying, adjusting the humidity to be within the range of 40-50%, and demoulding after the temperature of the sausage casing is reduced to room temperature to obtain a dried sausage casing;
(8) crushing: crushing the dried sausage casing into 200 meshes;
(9) refining: refining the crushed sausage casing into a gel, adding acetone and ammonia liquor, and mixing to prepare a spinning solution;
(10) spinning: filtering the spinning solution in the spinning solution by a filter, and spraying 120 silk threads by a spinning pump nozzle; the silk thread bundle is solidified in the solidification liquid and is conveyed to a first twisting device by a silk thread roller to carry out first twisting; the silk threads enter a first cross-linking groove through a godet roller for cross-linking reaction, then enter a first rinsing groove through the godet roller for water washing, and then enter a second twist device for twisting again after the water washing; the godet roller after the second twisting enters a drying box for drying, and then the silk thread is sent into a second cross-linking groove for cross-linking treatment by the godet roller and then enters a second rinsing groove for rinsing; and naturally drying;
(11) polishing and gluing: polishing the naturally dried yarns in the step 10; soaking the wire harness into the glue solution and uniformly extruding;
(12) and drying, namely drying the glued silk thread, and sending the silk thread into a winding roller by a silk guide roller to be wound into a cylindrical finished product.
Further, the specific operation of virus inactivation is as follows: soaking the casing with foreign protein removed in 5-7% edible hydrogen peroxide solution at 40-44 deg.C for 13-17 hr, and washing with purified water for 3-5 times.
Further, the concentration of the sodium chloride solution in the collagen degreasing process is 14-16%, and the soaking time is 70-78 minutes.
Further, the chitosan atomization is specifically operative to: uniformly spraying the chitosan saturated solution with the temperature of 36-48 ℃ on the surface of the sausage casing, standing for 44-56 minutes, then spraying and standing, and repeating the steps for 3-5 times.
Further, in the refining process, the weight ratio of acetone to ammonia liquor is 1: 2.3.
the above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.
Claims (5)
1. A production process of a medical thread which can be absorbed by human body is characterized by comprising the following production steps:
(1) selecting materials: selecting casings qualified by quarantine, and cutting small intestine parts;
(2) removing foreign protein: cleaning the inner wall of the small intestine casing, and separating and dropping intestinal chorion, mucosa and serosa in the casing by using a special tool;
(3) virus inactivation: soaking the casing with foreign protein removed in edible hydrogen peroxide solution and cleaning;
(4) degreasing collagen: cleaning the casing with clear water, soaking the casing in a sodium chloride solution, and then separating and cutting fat in the casing collagen to obtain a relatively pure collagen tissue;
(5) casing extension: cutting the casing into pieces, and then extending the pieces to a set length and width by using extension equipment;
(6) atomizing chitosan: adding excessive chitosan into acetic acid solution, fully stirring to prepare chitosan saturated solution, uniformly spraying the chitosan saturated solution on the surface of the sausage casing, standing, and repeating the spraying and standing operations for multiple times;
(7) drying and curing: sleeving the sausage casing atomized by chitosan on a drying mould, and drying for 1-2 hours at the temperature of 50-65 ℃; then heating to 70-80 ℃, and drying for 2-4 hours; after drying, adjusting the humidity to be within the range of 40-50%, and demoulding after the temperature of the sausage casing is reduced to room temperature to obtain a dried sausage casing;
(8) crushing: crushing the dried sausage casing into 200 meshes;
(9) refining: refining the crushed sausage casing into a gel, adding acetone and ammonia liquor, and mixing to prepare a spinning solution;
(10) spinning: filtering the spinning solution in the spinning solution by a filter, and spraying 120 silk threads by a spinning pump nozzle; the silk thread bundle is solidified in the solidification liquid and is conveyed to a first twist device twist by the silk thread guide roller; the silk threads enter a first cross-linking groove through a godet roller for cross-linking reaction, then enter a first rinsing groove through the godet roller for water washing, and then enter a second twist device for twisting again after the water washing; the godet roller after the second twisting enters a drying box for drying, and then the silk thread is sent into a second cross-linking groove for cross-linking treatment by the godet roller and then enters a second rinsing groove for rinsing; and naturally drying;
(11) polishing and gluing: polishing the spun yarn dried in the step S10; soaking the wire harness into the glue solution and uniformly extruding;
(12) and drying, namely drying the glued silk thread, and sending the silk thread into a winding roller by a silk guide roller to be wound into a cylindrical finished product.
2. The process for producing a body-absorbable medical thread according to claim 1, wherein the specific operation of virus inactivation is: soaking the casing with foreign protein removed in 5-7% edible hydrogen peroxide solution at 40-44 deg.C for 13-17 hr, and washing with purified water for 3-5 times.
3. The process for producing a body absorbable medical thread as claimed in claim 1, wherein the concentration of the sodium chloride solution in the collagen defatting process is 14-16% and the soaking time is 70-78 minutes.
4. The process for producing a body absorbable medical thread of claim 1, wherein the chitosan atomization is specifically operated to: uniformly spraying the chitosan saturated solution with the temperature of 36-48 ℃ on the surface of the sausage casing, standing for 44-56 minutes, then spraying and standing, and repeating the steps for 3-5 times.
5. The process for producing a body-absorbable medical thread according to claim 1, wherein the weight ratio of acetone to ammonia solution in the refining process is 1: 2.3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111320494.8A CN114099762A (en) | 2021-11-09 | 2021-11-09 | Production process and application of medical thread capable of being absorbed by human body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111320494.8A CN114099762A (en) | 2021-11-09 | 2021-11-09 | Production process and application of medical thread capable of being absorbed by human body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114099762A true CN114099762A (en) | 2022-03-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111320494.8A Withdrawn CN114099762A (en) | 2021-11-09 | 2021-11-09 | Production process and application of medical thread capable of being absorbed by human body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114099762A (en) |
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2021
- 2021-11-09 CN CN202111320494.8A patent/CN114099762A/en not_active Withdrawn
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Application publication date: 20220301 |
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| WW01 | Invention patent application withdrawn after publication |