CN114084478A

CN114084478A - Independent sub-control type nucleic acid sample storage box

Info

Publication number: CN114084478A
Application number: CN202210056268.1A
Authority: CN
Inventors: 周颖
Original assignee: Nantong Heruiyuan Biotechnology Co ltd
Current assignee: Nantong Heruiyuan Biotechnology Co ltd
Priority date: 2022-01-18
Filing date: 2022-01-18
Publication date: 2022-02-25
Anticipated expiration: 2042-01-18
Also published as: CN114084478B

Abstract

The invention discloses an independent sub-control type nucleic acid sample storage box which comprises a box body and a pipe body, wherein a control module is arranged at the bottom of the box body, a storage part is arranged on the box body, a supporting cylinder is fixedly arranged at the bottom of the storage part, a rotary cylinder is rotatably supported outside the supporting cylinder through a bearing and is in sliding contact with the inner wall of the storage part, a fastening device is arranged in the rotary cylinder, a bearing plate is arranged in the rotary cylinder, and a threaded rod is fixedly connected to the lower surface of the bearing plate. When the pipe body is inserted, the friction force between the elastic shifting plate and the pipe body can enable the threaded end to be connected with the threaded cover more tightly, so that the threaded cover is prevented from being incompletely screwed; the sample preservation solution can be intermittently detected whether to deteriorate or not; when the sample preservation solution leaks, people can be warned to clean the sample preservation solution in time; every body all is in independent storage portion, can set up different save temperature, can not influence the save of other bodys when taking out one of them body.

Description

Independent sub-control type nucleic acid sample storage box

Technical Field

The invention relates to the technical field of nucleic acid sample preservation, in particular to an independent sub-control type nucleic acid sample preservation box.

Background

Nucleic acid sample need be preserved under low temperature environment, but current sample preservation case can only regulate and control the same temperature, can't realize the independent accuse temperature of different samples according to the sample characteristics, in addition, the preservation case can frequently appear vibrations, the problem of aversion in the transportation, if the screw cap of body does not screw up or the junction appears the damage, all can lead to the leakage of preserving fluid, cause the damage of nucleic acid sample, for this reason, we propose an independent branch accuse formula nucleic acid sample preservation case.

Disclosure of Invention

The invention aims to solve the problems that the storage box in the prior art cannot independently control the temperature and can not warn people when a storage solution leaks, and provides an independent sub-control type nucleic acid sample storage box.

In order to achieve the purpose, the invention adopts the following technical scheme:

an independent sub-control type nucleic acid sample storage box comprises a box body and a pipe body, wherein the bottom of the box body is provided with a control module, the box body is provided with a storage part, the bottom of the storage part is fixedly provided with a supporting cylinder, the outer side of the supporting cylinder is rotatably supported with a rotary drum through a bearing, the rotary drum is in sliding contact with the inner wall of the storage part, a fastening device is arranged in the rotary drum, a bearing plate is arranged in the rotary drum, the lower surface of the bearing plate is fixedly connected with a threaded rod, an annular plate is arranged on the threaded rod in a threaded manner, the annular plate is fixedly connected with the inner wall of the rotary drum, the lower end of the threaded rod is fixedly connected with a round rod, a spring is fixedly arranged between the round rod and the bottom wall of the supporting cylinder, an elastic gasket corresponding to the position of the storage part is fixedly arranged on the upper surface of the box body, a trigger mechanism is arranged in the elastic gasket, and a detection mechanism is arranged in the storage part;

the trigger mechanism comprises a pressure sensor and a trigger module, a refrigerator is installed in the storage part and electrically connected with the pressure sensor, the detection mechanism comprises a light source output end and a light source receiving end, the light source output end is installed in the storage part, the light source output end is located above the rotary drum and inclines towards the pipe body, the light source receiving end is installed on the upper surface of the annular plate, and the light source output end and the light source receiving end are both electrically connected with the pressure sensor.

Further, the pipe body is inserted into the rotary drum, a threaded end is arranged on the upper portion of the pipe body, the threaded end is connected with a threaded cover in a matched mode, a buckle plate corresponding to the threaded cover in position is movably mounted on the box body, a sealing ring is embedded in the upper surface of the elastic washer, and the diameter of the sealing ring is equal to that of the threaded cover.

Further, the upper surface of sealing ring inlays and is equipped with many seal wires, and the coaxial equidistance of many seal wires distributes, many the seal wire all with trigger module electric connection.

Further, the bearing plate is made of transparent materials and is of a concave lens structure, and the projection area of the light source receiving end in the vertical direction is larger than that of the bearing plate in the vertical direction.

Further, fastener includes the fixed cover with the coaxial setting of rotary drum, the lateral wall of fixed cover and the inside wall fixed connection of rotary drum, circumference symmetry is provided with a plurality of elasticity in the fixed cover and dials the board, and every elasticity dials the board and all winds along circumference and establish.

The invention has the following advantages: when the pipe body is inserted, the friction force between the elastic shifting plate and the pipe body can enable the threaded end to be connected with the threaded cover more tightly, so that the threaded cover is prevented from being incompletely screwed, the threaded cover is abutted against the elastic gasket, and the storage part can be sealed; the sample preservation solution can be intermittently detected whether to deteriorate or not; when the sample preservation solution leaks, people can be warned to clean the sample preservation solution in time; every body all is in independent storage portion, can set up different save temperature, can not influence the save of other bodys when taking out one of them body.

Drawings

FIG. 1 is a schematic diagram of a nucleic acid sample storage box with independent control according to the present invention;

FIG. 2 is a schematic diagram of the internal structure of the storage part of the independent sub-control type nucleic acid sample storage box according to the present invention;

FIG. 3 is an enlarged view taken at A in FIG. 2;

FIG. 4 is a schematic diagram of the distribution of guide wires in an independently controlled nucleic acid sample storage case according to the present invention;

FIG. 5 is a schematic diagram of the internal structure of a support cylinder in an independently controlled nucleic acid sample storage box according to the present invention;

FIG. 6 is a schematic structural diagram of a fixing sleeve in an independent separate control type nucleic acid sample storage box according to the present invention.

In the figure: the refrigerator comprises a box body 1, a pinch plate 2, a thread cover 3, an elastic washer 4, a tube body 5, a thread end 51, a rotary drum 6, a fixed sleeve 7, a refrigerator 8, a support cylinder 9, a bearing plate 10, a pressure sensor 11, a sealing ring 12, a trigger module 13, a light source output end 14, a guide wire 15, a light source receiving end 16, a ring plate 17, a bearing 18, a limiting lantern ring 19, a spring 20, a round rod 21, a threaded rod 22, an elastic shifting plate 23, a control module 24 and a storage part 25.

Detailed Description

Referring to fig. 1, 2 and 5, an independent sub-control type nucleic acid sample storage box comprises a box body 1 and a pipe body 5, wherein a control module 24 is arranged at the bottom of the box body 1, a storage part 25 is arranged on the box body 1, a supporting barrel 9 is fixedly arranged at the bottom of the storage part 25, a rotary barrel 6 is rotatably supported at the outer side of the supporting barrel 9 through a bearing 18, the rotary barrel 6 is in sliding contact with the inner wall of the storage part 25, a fastening device is arranged in the rotary barrel 6, a bearing plate 10 is arranged in the rotary barrel 6, a threaded rod 22 is fixedly connected to the lower surface of the bearing plate 10, an annular plate 17 is arranged on the threaded rod 22 in a threaded manner, the annular plate 17 is fixedly connected with the inner wall of the rotary barrel 6, when the threaded rod 22 moves downwards, the annular plate 17 rotates under the cooperation of threads, the annular plate 17 can drive the rotary barrel 6 to rotate synchronously, a round rod 21 is fixedly connected to the lower end of the threaded rod 22, and a spring 20 is fixedly arranged between the round rod 21 and the bottom wall of the supporting barrel 9, when the tube body 5 is inserted into the rotary drum 6 and presses the bearing plate 10, the spring 20 is compressed, the upper surface of the box body 1 is fixedly provided with an elastic gasket 4 corresponding to the position of the storage part 25, a trigger mechanism is arranged in the elastic gasket 4, and a detection mechanism is arranged in the storage part 25;

referring to fig. 1-2, a pipe body 5 is inserted into a rotary drum 6, a threaded end 51 is arranged at the upper part of the pipe body 5, the threaded end 51 is connected with a threaded cover 3 in a matching way, a buckle plate 2 corresponding to the threaded cover 3 is movably arranged on a box body 1, the buckle plate 2 is connected with the box body 1 in various ways without limitation, the buckle plate 2 plays a role of fixing the threaded cover 3 and the pipe body 5, a sealing ring 12 is embedded on the upper surface of an elastic gasket 4, the diameter of the sealing ring 12 is equal to that of the threaded cover 3, and after the buckle plate 2 is buckled, the threaded cover 3 is abutted against the sealing ring 12;

it should be noted that, a plurality of storage portions 25 are provided in the box body 1, and the structures of the devices in each storage portion 25 are the same, and for the sake of clarity and simplicity of the drawings, only one set of the buckle plate 2, the elastic washer 4, the storage portion 25, and the like are illustrated.

Referring to fig. 3-4, the triggering mechanism includes a pressure sensor 11 and a triggering module 13, a refrigerator 8 is installed in the storage portion 25, the refrigerator 8 is electrically connected to the pressure sensor 11, a plurality of guide wires 15 are embedded in the upper surface of the sealing ring 12, the guide wires 15 are coaxially and equidistantly distributed, the guide wires 15 are electrically connected to the triggering module 13, and two adjacent guide wires 15 or the guide wires 15 are conducted to serve as triggering conditions of the triggering module 13.

Referring to fig. 3 and 5, the detection mechanism includes a light source output end 14 and a light source receiving end 16, the light source output end 14 is installed in the storage portion 25, the light source output end 14 is located above the rotating drum 6 and inclines towards the tube body 5, the light source output end 14 can emit a bundle of light with good collimation property to the tube body 5 after being started, the bundle of light is emitted outwards from the bottom of the tube body 5 after being refracted by the tube body 5, the light source receiving end 16 is installed on the upper surface of the annular plate 17, the light source output end 14 and the light source receiving end 16 are both electrically connected with the pressure sensor 11, and the light source output end 14 and the light source receiving end 16 are intermittently and synchronously started after the pressure value detected by the pressure sensor 11 reaches a threshold value.

The bearing plate 10 is made of a transparent material, the bearing plate 10 is of a concave lens structure, the bearing plate 10 is preferably made of a transparent resin material with better wear resistance, light transmittance can be guaranteed, rigid collision with the tube body 5 can be avoided, and the projection area of the light source receiving end 16 in the vertical direction is larger than that of the bearing plate 10 in the vertical direction;

the tube body 5 and the bearing plate 10 are made of transparent materials, and the characteristics of transparency are not shown in the attached drawings in order to make the positions, structures and connection relations of the tube body and the bearing plate clearer.

Referring to fig. 6, the fastening device includes the fixed cover 7 that sets up with the rotary drum 6 is coaxial, the lateral wall of fixed cover 7 and the inside wall fixed connection of rotary drum 6, the circumferential symmetry is provided with a plurality of elasticity in the fixed cover 7 and dials board 23, and every elasticity dials board 23 and all winds along circumference, when body 5 extrudees loading board 10 downwards, loading board 10 drives threaded rod 22 downstream, thereby make fixed cover 7 also take place to rotate, the rotation direction that board 23 was dialled to elasticity this moment is opposite with the screw thread direction of screw thread end 51, frictional force between board 23 and the body 5 is dialled to elasticity can make screw thread end 51 be connected inseparabler with screw cap 3 promptly, when inserting body 5, the hand screw cap 3 of user, screw cap 3 is difficult to take place to rotate, in order to avoid screw cap 3 to screw up completely not.

When the tube body 5 is inserted into the rotary drum 6, the bottom of the tube body 5 abuts against the bearing plate 10, the bearing plate 10 is pushed downwards, the threaded rod 22 moves downwards, the rotary drum 6 can be driven to synchronously rotate by the annular plate 17 because the threaded rod 22 is in threaded connection with the annular plate 17, when the rotary drum 6 rotates, the elastic shifting plate 23 in the fixed sleeve 7 can rub against the tube body 5, and under the action of friction force, the threaded end 51 at the upper part of the tube body 5 can be more closely connected with the threaded cover 3 (when the tube body 5 is inserted, a user holds the threaded cover 3 by hand, the threaded cover 3 is difficult to rotate), so that the threaded cover 3 is prevented from being incompletely screwed, and the sealing of the tube body 5 is ensured;

in particular, the opening at the upper end of the drum 6 for inserting the tube 5 is small, so the distance between the opening and the tube 5 is small, when a user inserts the tube 5 downwards, the air in the drum 6 cannot be discharged quickly, and the user feels the resistance of the air, so that the speed of inserting the tube 5 is reduced, and the tube 5 and the carrier plate 10 are prevented from being collided violently;

then, the user fixes the threaded cover 3 by the buckle 2, so that the pipe body 5 is stably arranged in the storage part 25, the pipe body 5 is prevented from shaking greatly when the box body 1 moves, and when the buckle 2 is completely buckled, the threaded cover 3 is abutted against the elastic gasket 4, and the storage part 25 can be sealed;

after the pressure sensor 11 is squeezed, the pressure sensor sends an electric signal to the control module 24, the control module 24 controls the refrigerator 8 in the corresponding storage part 25 to be opened, so that the storage part 25 is kept at a low temperature, meanwhile, the control module 24 also controls the light source output end 14 and the light source receiving end 16 to be opened discontinuously, the light source output end 14 sends a beam of light with good collimation to the tube body 5 after being opened, the beam of light is sent out from the bottom of the tube body 5 after being refracted by the tube body 5, the light is received by the light source receiving end 16 after being dispersed by the bearing plate 10, when the sample preservation solution is not deteriorated, the color of the light received by the light source receiving end 16 is unchanged, the color of the light received by the light source receiving end 16 is within a certain wavelength range, when the sample preservation solution is deteriorated, the color of the sample preservation solution is changed, the light source receiving end 16 receives light with different wavelengths, and an external computer passes through the change of the wavelength of the light, whether the sample preservation solution is going bad can be judged;

when box 1 is when removing, the preserving fluid in the body 5 can take place to rock, appear damaged if screw cap 3 or threaded end 51, during the sealed not tight scheduling problem that the specification mismatch leads to, the preserving fluid can be followed both junctions and oozed, is switched on after 15 or the 15 contact preserving fluids of many seal wires of two adjacent seal wires, reaches the trigger condition who triggers module 13, triggers module 13 and can send specific signal to the external computer to remind people in time to clear up damaged body 5, change.

Claims

1. The independent sub-control type nucleic acid sample storage box comprises a box body (1) and a pipe body (5), and is characterized in that a control module (24) is arranged at the bottom of the box body (1), a storage part (25) is arranged on the box body (1), a supporting cylinder (9) is fixedly mounted at the bottom of the storage part (25), a rotary cylinder (6) is rotatably supported at the outer side of the supporting cylinder (9) through a bearing (18), the rotary cylinder (6) is in sliding contact with the inner wall of the storage part (25), a fastening device is arranged in the rotary cylinder (6), a bearing plate (10) is arranged in the rotary cylinder (6), a threaded rod (22) is fixedly connected to the lower surface of the bearing plate (10), an annular plate (17) is arranged on the threaded rod (22) in a threaded manner, the annular plate (17) is fixedly connected with the inner wall of the rotary cylinder (6), a round rod (21) is fixedly connected to the lower end of the threaded rod (22), a spring (20) is fixedly arranged between the round rod (21) and the bottom wall of the supporting cylinder (9), an elastic gasket (4) corresponding to the position of the storage part (25) is fixedly arranged on the upper surface of the box body (1), a trigger mechanism is arranged in the elastic gasket (4), and a detection mechanism is arranged in the storage part (25);

the trigger mechanism comprises a pressure sensor (11) and a trigger module (13), a refrigerator (8) is installed in the storage portion (25), the refrigerator (8) is electrically connected with the pressure sensor (11), the detection mechanism comprises a light source output end (14) and a light source receiving end (16), the light source output end (14) is installed in the storage portion (25), the light source output end (14) is located above the rotary drum (6) and inclines towards the pipe body (5), the light source receiving end (16) is installed on the upper surface of the annular plate (17), and the light source output end (14) and the light source receiving end (16) are both electrically connected with the pressure sensor (11).

2. The independent sub-control type nucleic acid sample storage box according to claim 1, wherein the tube body (5) is inserted into the rotary drum (6), the upper portion of the tube body (5) is provided with a threaded end (51), the threaded end (51) is connected with the threaded cap (3) in a matching manner, the box body (1) is further movably provided with a buckle plate (2) corresponding to the threaded cap (3), the upper surface of the elastic gasket (4) is embedded with a sealing ring (12), and the diameter of the sealing ring (12) is equal to that of the threaded cap (3).

3. The independent sub-control type nucleic acid sample storage box according to claim 2, wherein a plurality of guide wires (15) are embedded in the upper surface of the sealing ring (12), the plurality of guide wires (15) are coaxially and equidistantly distributed, and the plurality of guide wires (15) are electrically connected with the trigger module (13).

4. The independently controlled nucleic acid sample storage container according to claim 1, wherein the support plate (10) is made of a transparent material, and the support plate (10) has a concave lens structure, and the projected area of the light source receiving end (16) in the vertical direction is larger than the projected area of the support plate (10) in the vertical direction.

5. The independently controlled nucleic acid sample storage box according to claim 1, wherein the fastening device comprises a fixing sleeve (7) coaxially disposed with the rotary drum (6), the outer side wall of the fixing sleeve (7) is fixedly connected with the inner side wall of the rotary drum (6), a plurality of elastic pulling plates (23) are symmetrically disposed on the inner circumference of the fixing sleeve (7), and each elastic pulling plate (23) is circumferentially wound.