CN114081522A

CN114081522A - PET imaging assembly, imaging device and detection method

Info

Publication number: CN114081522A
Application number: CN202210069472.7A
Authority: CN
Inventors: 尼古拉·达申佐; 周峰; 吕旭东; 祝慧刚; 张春; 孙意成; 谢庆国
Original assignee: Raycan Technology Co Ltd
Current assignee: Raycan Technology Co Ltd
Priority date: 2022-01-21
Filing date: 2022-01-21
Publication date: 2022-02-25
Anticipated expiration: 2042-01-21
Also published as: WO2023138196A1; CN114081522B

Abstract

The utility model provides a PET imaging assembly, imaging device and detection method, PET imaging assembly includes multilayer detector ring, multilayer detector ring has the same axis of symmetry and piles up the arrangement, every layer of detector ring's internal diameter increases progressively in proper order or decreases progressively in order to enclose into a space that has the opening, wherein, every layer of detector ring includes a plurality of detectors that set up along circumference array, the detection direction of every detector all points to inside the opening space, the detection direction between the different detector rings is not identical with the contained angle between the plane of opening place. The technical scheme of the application realizes a large solid angle coverage surface by a small number of detectors, and greatly saves the system cost on the premise of not sacrificing the detection precision.

Description

PET imaging assembly, imaging device and detection method

Technical Field

The application relates to the technical field of PET imaging, in particular to a PET imaging component, an imaging device and a detection method.

Background

Positron Emission Tomography (PET) is used as a large-scale and sophisticated nuclear medicine imaging device, and a radioactive tracer with biological activity is injected into a living body and participates in metabolism in the living body, so that positrons generated by radionuclide decay are combined with negative electrons in tissues in the living body to be annihilated, and two gamma photons with the same energy and opposite movement directions are radiated.

The detector of the PET system can convert the gamma photon pair into a visible light signal after detecting the gamma photon pair and further convert the visible light signal into an electric signal for outputting, and the spatial distribution of the radioactive tracer in the living body can be obtained through processing, analyzing and reconstructing the signal, so that the functional metabolism condition of each tissue and organ in the living body can be visualized. In conclusion, PET allows noninvasive, quantitative, and dynamic assessment of metabolic levels, biochemical reactions, and functional activities in vivo, so that lesions can be detected by PET before they develop obvious anatomical changes. Therefore, the early discovery and early treatment are realized, and the method plays an extremely important role in reducing the death rate of serious diseases such as nervous system and the like.

For brain examination, a conventional clinical PET-CT system is currently used clinically for brain scanning. The patient needs to measure height as required to ensure that the maximum load capacity of the PET table and the scanning aperture of the PET-CT scanner are not exceeded to ensure that the region of interest is optimally displayed. In addition, the patient also needs to measure body weight to confirm the dose of the drug. Since the injected drug is glucose labeled with a radioactive isotope, the patient also needs to measure the blood sugar to ensure that the doctor can control the blood sugar content in the patient to be in a proper range during the drug injection. After the examination is finished, the patient needs to receive the injection of the radioactive drug, and after the injection, the patient has a quiet rest at a designated place to ensure that the drug can be fully transported to the brain, and finally the patient lies on a PET-CT equipment scanning bed for examination under the guidance of a doctor.

At present, although the mass of the human brain only accounts for about 2% of the human body weight, the human brain is the highest central nerve of the human body, the consumed energy accounts for 20% -25% of the energy of the whole body, and the human brain is the most vigorous tissue organ in the metabolism of the human body. Brain diseases have serious harm to human health, such as cerebrovascular diseases, brain tumors and Parkinson's disease, the morbidity and disability rate of the diseases are very high, and a corresponding treatment scheme can be formulated according to the imaging of the neurogenic brain function of a patient, so that the improvement of the imaging quality of a brain region can play a positive guiding role in the treatment of the brain disease patient.

PET can provide good guidance for diagnosis of brain diseases such as brain tumor, cerebral infarction and epilepsy, and can also be used for research and exploration of brain tissue response to external stimuli. The head contains the most important central nervous system of human beings, and the tissue structure is precise, so the requirement on the quality of brain imaging is high. The resolution of a clinical PET system is low, the single scanning time is long, and the system is not suitable for imaging patients with brain diseases; and the brain disease patient is difficult to keep still for a long time, and the head motion influences the imaging quality, hardly satisfies the requirement of high accuracy brain formation of image.

Because clinical PET equipment is mainly used for human whole-body detection at present, the aperture of the detector ring is large, the signal-to-noise ratio of the equipment is low when the equipment is used for brain imaging, and the image accuracy is relatively poor. At present, research is carried out to reduce the aperture of a PET detector ring layer by layer to build a detector ring similar to a hemisphere, however, the design has a larger gap, which seriously affects the effective detection area of the detector ring (First programming of a differentiated PET system with the chemical detector arrangement [ J ]. Physics in Medicine & Biology, 2019). The current research aiming at neurodegenerative diseases needs that a PET system has extremely high sensitivity so as to realize rapid dynamic PET imaging and accurately obtain dynamic quantitative parameters of cerebral metabolism. There is therefore a pressing need for a brain-specific dynamic PET scanning device for dynamic imaging of patients to explore the relationship between patient movement and neurological dysfunction.

The existing PET equipment for clinical brain scanning has the problems that the volume is large, the equipment is inflexible and cannot be moved, a patient must lie down to scan the brain, and the equipment cannot adapt to special conditions, such as the fact that the patient cannot move or change the posture after getting ill, or the PET scanning in an operating room and the like. The problems of relatively long scanning time, high dosage of the medicine injection of a patient, incapability of dynamic imaging and the like exist due to the large aperture of the clinical PET equipment and low system sensitivity.

The statements in this background section merely disclose technology known to the inventors and do not, of course, represent prior art in the art.

Disclosure of Invention

The PET imaging component, the imaging device and the detection method avoid the field limitation caused by the fixation of a PET instrument, and realize that the PET scanning can be carried out on a patient in various postures such as sitting, lying and standing.

According to an aspect of the application, a PET imaging component is provided, which includes a plurality of layers of detector rings, the layers of detector rings have the same symmetry axis and are arranged in a stacked manner, the inner diameter of each layer of detector ring is sequentially increased or decreased to form a space with an opening, wherein each layer of detector ring includes a plurality of detectors arranged along a circumferential array, the detection direction of each detector points to the inside of the space with the opening, and the detection direction between the detector rings and the included angle between the planes with the opening are not completely the same.

According to some embodiments, the PET imaging assembly further comprises a housing, the detectors being disposed on the housing.

According to some embodiments, the shape of the housing comprises a hemisphere, an ellipsoid, a cuboid, a cube.

According to some embodiments, the PET imaging assembly further includes a stator securing the detector to the housing.

According to some embodiments, the probe includes at least one probe and back-end electronics, the at least one probe being connected to the back-end electronics by a flex cable.

According to some embodiments, the probe comprises a plurality of crystals arranged in an array and a plurality of silicon photomultipliers arranged in an array, the plurality of crystals coupled to the plurality of silicon photomultipliers.

According to some embodiments, the plurality of crystals and the plurality of silicon photomultipliers are each in an M x N array arrangement, where M, N are each natural numbers.

According to some embodiments, the plurality of crystals and the plurality of silicon photomultipliers are each arranged in a 6 x 6 array.

According to some embodiments, the number of multilayer detector rings is 6 or more layers.

According to some embodiments, the number of detectors on the multi-layered detector ring is at least 65.

According to some embodiments, the multi-layer detector ring comprises: the first layer of detector ring, the second layer of detector ring, the third layer of detector ring, the fourth layer of detector ring, the fifth layer of detector ring and the sixth layer of detector ring are sequentially stacked and arranged in a direction perpendicular to the plane where the opening is located; the first layer of detector rings are arranged close to the opening, and the sixth layer of detector rings are arranged far away from the opening.

According to some embodiments, the first tier detector ring has a ring inner diameter of 0-237 mm.

According to some embodiments, the first and second tier detector rings each comprise at least 28 detectors.

According to some embodiments, the angle between the detection direction of the detectors of the first-layer detector ring and the plane of the opening is 0.

According to some embodiments, the second tier detector ring has a ring inner diameter of 0-232.6 mm.

According to some embodiments, the detection direction of the detectors of the second-layer detector ring and the plane of the opening form an included angle of 0-10 ︒.

According to some embodiments, the third tier detector ring has a ring inner diameter of 0-219.8 mm.

According to some embodiments, the third tier detector ring comprises at least 26 detectors.

According to some embodiments, the detection direction of the detectors of the third-layer detector ring and the plane of the opening form an included angle of 0-18.8 ︒.

According to some embodiments, the fourth tier detector ring has a ring inner diameter of 0-196.2 mm.

According to some embodiments, the fourth tier detector ring comprises at least 20 detectors.

According to some embodiments, the detection direction of the detectors of the fourth-layer detector ring and the plane of the opening form an included angle of 0-35.8 ︒.

According to some embodiments, the fifth layer detector ring has a ring inner diameter of 0-161.2 mm.

According to some embodiments, the fifth layer detector ring comprises at least 16 detectors.

According to some embodiments, the detection direction of the detectors of the fifth-layer detector ring and the plane of the opening form an included angle of 0-49.4 ︒.

According to some embodiments, the sixth tier detector ring has a ring inner diameter of 0-118.2 mm.

According to some embodiments, the sixth tier of detector rings comprises at least 12 detectors.

According to some embodiments, the detection direction of the detectors of the sixth-layer detector ring and the plane of the opening form an included angle of 0-62.4 ︒.

According to some embodiments, an inner diameter of the multi-layer detector ring is adjustable.

According to some embodiments, the mounting angle of the multi-layered detector ring is adjustable.

According to an aspect of the present application, there is provided a PET imaging apparatus comprising: the PET imaging assembly, the rotating assembly, the lifting assembly and the control assembly are used for adjusting the angle of the PET imaging assembly; the lifting assembly is connected with the rotating assembly and/or the PET imaging assembly and is used for adjusting the height of the PET imaging assembly; the control assembly is used for controlling the PET imaging assembly, the rotating assembly and the lifting assembly.

According to an aspect of the present application, a detection method using the PET imaging apparatus is provided, including: the control component receives a terminal instruction; the control component controls the lifting component to lift and is used for adapting to the height of a person to be detected; the control assembly controls the rotation assembly to rotate so as to adjust the angle of the PET imaging assembly.

Based on foretell PET imaging components, imaging device and detection method, the detector is arranged according to hemispherical structure, and structural shape laminating head need not to carry out the full coverage to the head, increases the solid angle covering surface of detector face through open structure, not only can adapt to different detection demands, can promote imaging device's spatial resolution moreover. The PET imaging device can achieve high sensitivity by using a small number of detectors, is low in production cost and flexible in structure, and can adjust the scanning body position according to the actual condition of a patient.

For a better understanding of the nature and technical content of the present application, reference should be made to the following detailed description and accompanying drawings, which are provided to illustrate the present application and are not intended to limit the scope of the present application in any way.

Drawings

Embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. The accompanying drawings, which are incorporated herein and constitute part of this disclosure, serve to provide a further understanding of the disclosure. The exemplary embodiments of the present disclosure and their description are provided to explain the present disclosure and not to limit the present disclosure. In the drawings:

fig. 1 shows a perspective view of an imaging assembly according to an exemplary embodiment of the present application.

FIG. 2 illustrates a top view of an imaging assembly according to an example embodiment of the present application.

Fig. 3 shows a front view of an imaging assembly according to an example embodiment of the present application.

Fig. 4 shows a schematic structural diagram of a detector according to an exemplary embodiment of the present application.

FIG. 5 illustrates a schematic structural view of a fixing sheet according to an exemplary embodiment of the present application.

Fig. 6-9 show swing views of an imaging assembly according to example embodiments of the present application.

Fig. 10-11 show rotational schematic diagrams of a rotating assembly according to an example embodiment of the present application.

Fig. 12-13 illustrate lifting and lowering schematic diagrams of a lifting assembly according to example embodiments of the present application.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the description of the present invention, it should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection, either mechanically, electrically, or in communication with each other; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly above and obliquely above the second feature, or simply meaning that the first feature is at a lesser level than the second feature.

The following disclosure provides many different embodiments or examples for implementing different features of the invention. To simplify the disclosure of the present invention, the components and arrangements of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or uses of other materials.

The preferred embodiments of the present invention will be described below with reference to the accompanying drawings, and it should be understood that the preferred embodiments described herein are merely for purposes of illustrating and explaining the present invention and are not intended to limit the present application.

Fig. 1 shows a perspective view of an imaging assembly according to an exemplary embodiment of the present application. FIG. 2 illustrates a top view of an imaging assembly according to an example embodiment of the present application. Fig. 3 shows a front view of an imaging assembly according to an example embodiment of the present application. Fig. 4 shows a schematic structural diagram of a detector according to an exemplary embodiment of the present application. FIG. 5 illustrates a schematic structural view of a fixing sheet according to an exemplary embodiment of the present application.

As shown in fig. 1 to 5, according to an exemplary embodiment of the present application, the present application discloses a PET imaging assembly 10, which includes a hemispherical shell 100 and a plurality of detector rings 200, wherein the plurality of detector rings 200 are sequentially disposed on the hemispherical shell 100, a center of each detector ring is collinear with a spherical center of the hemispherical shell 100, each detector ring includes a plurality of detectors 201 arranged in a circumferential array along a surface of the hemispherical shell 100, a detection direction of each detector 201 is directed to an inside of the hemispherical shell 100, but detection directions of detectors of different detector rings are not completely different.

The portable dynamic PET imaging component 10 is small, exquisite, flexible and movable, PET scanning of a patient can be achieved under various postures of sitting, lying, standing and the like, medicine injection amount of the patient is reduced, and dynamic PET imaging is achieved. The PET imaging assembly 10 is configured and dimensioned to conform to a human head detector and is arranged in a hemispherical configuration, with the configuration conforming to the head, increasing the solid angle coverage of the detector surface. The detector ring is rotatable, and is suitable for different detection requirements.

Referring to fig. 1, it can be seen that the number of the multi-layered detector ring 200 is 6 or more layers according to the embodiment of the present application. In the embodiment shown in FIG. 1, the multi-slice detector ring 200 includes: a first layer of detector rings 210, a second layer of detector rings 220, a third layer of detector rings 230, a fourth layer of detector rings 240, a fifth layer of detector rings 250 and a sixth layer of detector rings 260 are sequentially arranged along a direction perpendicular to the opening plane of the hemispherical shell 100; wherein the first tier of detector rings 210 is disposed proximate to the open end of the hemispherical shell 100 and the sixth tier of detector rings 260 is disposed proximate to the top end of the hemispherical shell 100.

The number of detectors 201 on the multi-slice detector ring 200 is at least 65, although the application is not limited to a specific number of slices of the detector ring 200 and a specific number of detectors 201. The ideal distance between the detection surfaces of the detectors 201 of each layer of detector ring is zero, that is, an included angle is formed between different detectors 201 in the same ring, so that the detection surfaces of the detectors 201 are ensured to form an approximately tightly-jointed ring, and the detectors 201 cover the whole hemispherical shell 100 to perform PET scanning.

Referring to FIG. 4, in accordance with an embodiment of the present application, the probe 201 includes at least one probe 2002 and back-end electronics 2003, with the at least one probe 2002 connected to the back-end electronics 2003 by flex-wiring.

The back-end electronics 2003 includes two spaced electronic output interfaces 20031.

The probe 2002 includes a plurality of crystals arranged in an array and a plurality of silicon photomultipliers arranged in an array, the plurality of crystals being coupled to the plurality of silicon photomultipliers. The probing direction generally refers to the extending direction of the crystal strip in the probe, and the probing direction has different angles with the opening plane of the hemispherical shell 100, and the probing direction is generally the same angle with the opening plane for different probes in the same probe ring.

The plurality of crystals and the plurality of silicon photomultipliers are arranged in an M × N array, wherein M, N are natural numbers. Optionally, the plurality of crystals and the plurality of silicon photomultipliers are each arranged in a 6 x 6 array, where M = N = 6.

Referring to fig. 5, the PET imaging assembly 10 further includes a fixing plate 202 for fixing the detector 201 to the hemispherical shell 100 according to the embodiment of the present application. The fixing plate 202 includes a bolt portion and a fixing portion at two ends, the fixing portion is located between two spaced electronic output interfaces 20031, the bolt portion of the fixing plate 202 has a bolt hole 2021, the hemispherical shell 100 has a fixing hole, the fixing hole can be a threaded hole, and the bolt portion is fixed in the fixing hole of the hemispherical shell 100 by a bolt. Therefore, the probe 201 is clamped between the fixing plate 202 and the hemispherical shell 100 through the fixing plate 202. The above-mentioned distance between the detectors 201 of each detector ring occurs because a certain distance is required between the fixing holes on the surface of the hemispherical shell 100.

In order to reduce the distance between the detectors 201 on each layer of detector ring, the centers of the bolt holes 2021 between two adjacent detectors 201 are on the same plane, and the two adjacent fixing holes avoid mutual interference, wherein the bolt portion at one end of one fixing plate 202 is arranged in an upward offset manner, and the bolt portion at one adjacent end of the other fixing plate 202 is arranged in a downward offset manner.

Through the fixed detector of stationary blade, be convenient for on the one hand according to the probe of the different resolution ratios of different detection imaging resolution ratio demands quick replacement, on the other hand is convenient for change the probe when the maintenance is examined.

According to an embodiment of the application, the inner diameter of the multi-layered detector ring 200 can be adjusted. The mounting angle of the multi-layered detector ring 200 can be adjusted. The inner diameter and the angle of the detector ring are adjusted to adapt to different patients to carry out different detections.

Additionally, the hemispherical shell 100 may also be sized to accommodate different patient head sizes. It should be noted by those skilled in the art that the housing 100 in the above embodiments is designed in a hemispherical shape, on one hand, to ensure that centers of the detector rings in each layer are located on the same straight line, and simultaneously, the detectors in each layer of the detector ring form a single detection ring, and on the other hand, the same detector ring is substantially free of openings, so that accuracy of acquiring coincidence events is ensured, and simultaneously, a solid angle coverage of the detectors is wider, which is helpful for improving quality of reconstructed images.

The detector 201 structure of the invention is arranged flexibly and changeably, the number of detector rings, the number of detectors 201 and the rotation angle of each ring can be changed flexibly, the structure of the detector ring includes but is not limited to a hemisphere, a cuboid, a cube, an ellipsoid and the like, the detector ring does not need to cover the head completely, the solid angle covering surface of the detector surface is increased through an open structure, the detector ring can adapt to different detection requirements, the spatial resolution of an imaging device is improved, the number of detectors can be reduced remarkably, and the cost is reduced remarkably.

According to the embodiment of the application, the inner diameter of the first layer of the detector ring 210 is 0-237 mm. The detection direction of the detectors 201 of the first layer of the detector ring 210 is parallel to the opening plane of the hemispherical shell 100.

According to the embodiment of the application, the inner diameter of the second-layer detector ring 220 is 0-232.6 mm. The included angle between the detection direction of the detector 201 of the second layer of detector ring 220 and the opening plane of the hemispherical shell 100 is 0-10 ︒. The first tier detector ring 210 and the second tier detector ring 220 each include at least 28 detectors 201.

According to the embodiment of the application, the inner diameter of the third layer of the detector ring 230 is 0-219.8 mm. The third tier detector ring 230 includes at least 26 detectors 201. The included angle between the detection direction of the detector 201 of the third-layer detector ring 230 and the opening plane of the hemispherical shell 100 is 0-18.8 ︒.

According to the embodiment of the application, the inner diameter of the fourth layer of detector ring 240 is 0-196.2 mm. The fourth tier detector ring 240 includes at least 20 detectors 201. The detection direction of the detectors 201 of the fourth layer of detector ring 240 forms an included angle of 0-35.8 ︒ with the opening plane of the hemispherical shell 100.

According to the embodiment of the application, the ring inner diameter of the fifth-layer detector ring 250 is 0-161.2 mm. The fifth layer detector ring 250 includes at least 16 detectors 201. The included angle between the detection direction of the detector 201 of the fifth-layer detector ring 250 and the opening plane of the hemispherical shell 100 is 0-49.4 ︒.

According to the embodiment of the application, the ring inner diameter of the sixth layer of detector ring 260 is 0-118.2 mm. The sixth tier detector ring 260 includes at least 12 detectors 201. The detection direction of the detector 201 of the sixth layer of detector ring 260 and the opening plane of the hemispherical shell 100 form an included angle of 0-62.4 ︒.

The PET imaging component 10 of the application uses relatively few detectors 201, so that on one hand, the sizes of a detector ring and a shell are relatively reduced, the detector ring and the shell are more attached to a head, and a solid angle covering surface formed by a detection surface is greatly improved, so that the detection sensitivity of PET imaging is improved; on the other hand, because the PET detector is quite expensive, the number of detectors is obviously reduced on the premise of not sacrificing the detection precision, and the system cost is greatly saved.

Fig. 6-9 illustrate a first rotational movement diagram of an imaging assembly according to an example embodiment of the present application. Fig. 10-11 illustrate a second rotational movement diagram of a rotating assembly according to an example embodiment of the present application. Fig. 12-13 illustrate lifting and lowering schematic diagrams of a lifting assembly according to example embodiments of the present application.

As shown in fig. 6-13, according to an aspect of the present application, there is provided a PET imaging apparatus 1 including: the PET imaging assembly 10, the rotating assembly 30, the lifting assembly 40 and the control assembly as above, wherein the rotating assembly 30 is used for adjusting the angle of the PET imaging assembly 10; the lifting assembly 40 is connected with the rotating assembly 30 and/or the PET imaging assembly 10 and is used for adjusting the height of the PET imaging assembly 10; the control assembly is used to control the PET imaging assembly 10, the rotation assembly 30, and the lift assembly 40.

The imaging assembly 10 in the PET imaging device of the present application can be adjusted in angle, that is, the opening direction of the hemispherical shell 100 of the imaging assembly 10 is vertically downward, and the rotating assembly 30 can make the imaging assembly 10 swing a certain angle around a horizontal axis, and can also make the imaging assembly 10 rotate a certain angle around a vertical axis. The lift assembly 40 may adjust the height of the imaging assembly 10. The angle of the imaging assembly 10, the rotating angle of the rotating assembly 30 and the lifting height of the lifting assembly 40 can be adjusted through the control assembly, and a manual calibration function is set on the basis of automatic adjustment, so that the imaging device 1 is more humanized.

The bottom end of the PET imaging device 1 of the present application further includes a universal wheel 12 for facilitating its movement. A handle 11 is provided at a rear side thereof near the top end for moving the image forming apparatus 1, and an operator can hold the handle 11 to facilitate the movement thereof. And further includes an emergency stop button 13 for terminating the detection operation of the PET imaging apparatus 1 in case of emergency.

The utility model provides a PET imaging device 1 is portable, nimble, with low costs for the patient can adopt to sit, crouch, stand when carrying out the PET imaging of brain and scan in different postures, satisfies the PET scanning demand of brain of different scenes, solves the unable problem that removes, system sensitivity is low of current brain imaging equipment. The small and exquisite convenient to use of equipment size, equipment cost is low, only needs to use a small amount of detectors can reach higher sensitivity, and equipment structure is nimble, can adjust the scanning position according to patient actual conditions.

According to an aspect of the present application, a detection method using the PET imaging apparatus 1 described above is proposed, including: the control component receives a terminal instruction; the control component controls the lifting component 40 to lift and is used for adapting to the height of the person to be detected; the control assembly controls the rotation of the rotating assembly 30 to adjust the angle of the PET imaging assembly 10.

When the patient stands or sits, the imaging device 1 can vertically face the head of the patient by adjusting the opening direction of the imaging assembly 10, rotate the imaging assembly 10 to the angle required for detection by the rotating assembly 30, and adjust the height of the imaging assembly 10 by the lifting assembly 40 to adapt to the head position of the patient to complete the PET scanning.

When the patient lies, the imaging device 1 can adjust the opening direction of the imaging assembly 10 to face the head of the patient in the horizontal direction, rotate the imaging assembly 10 to the angle required for detection through the rotating assembly 30, and adjust the height of the imaging assembly 10 through the lifting assembly 40 to adapt to the head position of the patient to complete the PET scanning.

Finally, it should be noted that: although the present disclosure has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the disclosure. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.

Claims

1. A PET imaging assembly, comprising:

a plurality of layers of detector rings having the same axis of symmetry and arranged in a stack, the inner diameter of each layer of the detector rings increasing or decreasing in sequence to enclose a space having an opening, wherein,

every layer the detector ring includes along a plurality of detectors of circumference array setting, every the detection direction of detector all points to inside the open-ended space, it is different detection direction between the detector ring with the contained angle between the plane of opening place is not identical.

2. The PET imaging assembly of claim 1, further comprising a housing on which the detectors are disposed.

3. The PET imaging assembly of claim 2, wherein the shape of the housing comprises a hemisphere, an ellipsoid, a cuboid, a cube.

4. The PET imaging assembly of claim 2, further comprising a stator securing the detector to the housing.

5. The PET imaging assembly of claim 1, wherein the detector includes at least one probe and backend electronics, the at least one probe connected to the backend electronics by a flex cable.

6. The PET imaging assembly of claim 5, wherein the probe includes a plurality of crystals arranged in an array and a plurality of silicon photomultipliers arranged in an array, the plurality of crystals coupled to the plurality of silicon photomultipliers.

7. The PET imaging assembly of claim 6, wherein the plurality of crystals and the plurality of silicon photomultipliers are each in an M x N array arrangement, wherein M, N are each natural numbers.

8. The PET imaging assembly of claim 1, wherein the number of multi-layered detector rings is 6 or more layers.

9. The PET imaging assembly of claim 1, wherein the number of detectors on the multi-slice detector ring is at least 65.

10. The PET imaging assembly of claim 1, wherein the multi-layered detector ring includes:

the first layer of detector ring, the second layer of detector ring, the third layer of detector ring, the fourth layer of detector ring, the fifth layer of detector ring and the sixth layer of detector ring are sequentially stacked and arranged in a direction perpendicular to the plane where the opening is located; wherein the content of the first and second substances,

the first layer of detector rings are arranged close to the opening, and the sixth layer of detector rings are arranged far away from the opening.

11. The PET imaging assembly of claim 10, wherein the first tier detector ring has a ring inner diameter of 0-237 mm.

12. The PET imaging assembly of claim 10, wherein the first and second tier detector rings each include at least 28 detectors.

13. The PET imaging assembly of claim 10, wherein the detector direction of the detectors of the first tier of detector rings is at an angle of 0 to the plane of the opening.

14. The PET imaging assembly according to claim 10 wherein the second tier detector ring has a ring inner diameter of 0-232.6 mm.

15. The PET imaging assembly of claim 10, wherein the detector direction of the detectors of the second tier detector ring is at an angle of 0-10 ︒ to the plane of the opening.

16. The PET imaging assembly of claim 10, wherein the third tier detector ring has a ring inner diameter of 0-219.8 mm.

17. The PET imaging assembly of claim 10, wherein the third tier detector ring includes at least 26 detectors.

18. The PET imaging assembly of claim 10, wherein the detection directions of the detectors of the third layer of detector rings form an angle of 0-18.8 ︒ with the plane of the opening.

19. The PET imaging assembly of claim 10 wherein the ring inner diameter of the fourth tier detector ring is 0-196.2 mm.

20. The PET imaging assembly of claim 10, wherein the fourth tier detector ring includes at least 20 detectors.

21. The PET imaging assembly of claim 10, wherein the detection directions of the detectors of the fourth tier of detector rings are at an angle of 0-35.8 ︒ to the plane of the opening.

22. The PET imaging assembly according to claim 10, wherein the fifth layer detector ring has a ring inner diameter of 0-161.2 mm.

23. The PET imaging assembly of claim 10, wherein the fifth layer detector ring includes at least 16 detectors.

24. The PET imaging assembly of claim 10, wherein the detector direction of the fifth layer of detector rings is 0-49.4 ︒ from the plane of the opening.

25. The PET imaging assembly of claim 10, wherein the sixth tier detector ring has a ring inner diameter of 0-118.2 mm.

26. The PET imaging assembly of claim 10, wherein the sixth tier detector ring includes at least 12 detectors.

27. The PET imaging assembly of claim 10, wherein the detection directions of the detectors of the sixth tier of detector rings are at an angle of 0-62.4 ︒ to the plane of the opening.

28. The PET imaging assembly of claim 1, wherein an inner diameter of the multi-layered detector ring is adjustable.

29. The PET imaging assembly of claim 1, wherein a mounting angle of the multi-layered detector ring is adjustable.

30. A PET imaging device, comprising:

the PET imaging assembly of any one of claims 1-29;

a rotation assembly for adjusting an angle of the PET imaging assembly;

the lifting assembly is connected with the rotating assembly and/or the PET imaging assembly and is used for adjusting the height of the PET imaging assembly;

and the control component is used for controlling the PET imaging component, the rotating component and the lifting component.

31. A method of inspection using a PET imaging device as claimed in claim 30, comprising:

the control component receives a terminal instruction;

the control component controls the lifting component to lift and is used for adapting to the height of a person to be detected;

the control assembly controls the rotation assembly to rotate so as to adjust the angle of the PET imaging assembly.