CN114055842A

CN114055842A - Be applied to rotary tablet press production process heat sink

Info

Publication number: CN114055842A
Application number: CN202111338608.1A
Authority: CN
Inventors: 马南; 李晨泰; 黄继哲; 胥宇轩
Original assignee: Shandong Sma Pharmatech Co ltd
Current assignee: Shandong Sma Pharmatech Co ltd
Priority date: 2021-11-12
Filing date: 2021-11-12
Publication date: 2022-02-18

Abstract

The invention relates to a cooling device applied to the production process of a rotary tablet press, belonging to the technical field of solid preparation production in pharmaceutical equipment; the device comprises a main shaft, a speed reduction box and a control system, wherein the main shaft is arranged on a working cylinder body and is connected with the speed reduction box; a turret is arranged above the main shaft, an upper die and a lower die are arranged in a hole of the turret, and the upper die and the lower die reciprocate in the hole in the vertical direction; a circulating cooling sleeve is arranged in the main shaft, a main shaft threaded sleeve is arranged above the circulating cooling sleeve, the lower part of the circulating cooling sleeve is inserted into the water inlet and return joint assembly, and the main shaft, the circulating cooling sleeve, the main shaft threaded sleeve and the turret are coaxial; the water inlet and return joint component comprises a water inlet and return joint, the water inlet and return joint is arranged on the main shaft, the upper part of the water inlet and return joint is connected with the circulating cooling jacket, a rotary joint is arranged below the water inlet and return joint, the inlet of the rotary joint is provided with two ports which are respectively connected to the water inlet pipe and the water return pipe, and the outlet of the rotary joint is provided with two ports which respectively correspond to the water inlet flow direction and the water outlet flow direction; the cooling effect is better, and the production is safe.

Description

Be applied to rotary tablet press production process heat sink

Technical Field

The invention relates to a cooling device applied to the production process of a rotary tablet press, and belongs to the technical field of solid preparation production in pharmaceutical equipment.

Background

Tablet presses are intended to meet industry standards, safety standards, etc. for related tablet presses. In the transmission area of the equipment, the pressing sheet area is sealed by using a protective cover. The core heating elements of the machine, such as a turret, a reduction gearbox and a main motor, are all arranged inside the machine and are sealed by using a protective cover. A tablet press is a continuously operating, high vibration, high load device. The equipment has high power and obvious heating. Particularly, after the equipment continuously runs for a long time, the temperature rise of the equipment and the temperature rise of the tabletting mold are obvious, and the produced tablets have obvious heat.

At present, the main heat dissipation mode of equipment is fan cooling, room temperature air of a tabletting chamber is sucked through an air inlet fan, and the equipment is cooled through a hot air exhaust mode through an air exhaust fan. There is also a method of cooling the transmission area of the device by adding an air conditioner to the device shield, the principle is similar to that of the common household air conditioner, the cold air in the transmission area circulates, and the heat is discharged from the outside through a radiator.

The currently mainstream methods have the following problems.

The fan cooling and air-conditioning cooling method comprises the following steps:

1. certain specialty tablets are very temperature sensitive, such as some active products, which can cause drug failure if the equipment temperature is too high, especially if the mold temperature for tableting is high. Affecting the quality of the medicine. (for example, live tetrads, where temperatures in excess of 50 cause death of live bacteria)

2. Some special tablets are very temperature sensitive, such as some materials, and the equipment temperature is too high to melt or stick on the tablet press die, resulting in improper continuous production or product failure. Affecting the quality of the medicine.

3. The cooling power of the fan cooling method is limited, and because the room temperature, humidity and other parameters of the tabletting room have strict requirements in GMP regulations, the room temperature is generally about 20 ℃, the heat exchange efficiency of air entering the transmission area is insufficient. The heat dissipation effect is not good.

4. For the air conditioner cooling method, the size of the tablet press is limited, the size of the air conditioner cannot be too large, and the cooling power is limited. And the air conditioner cooling can produce the comdenstion water, needs additionally to increase drainage device, and operating personnel need regularly clear up.

5. The heat discharges to the preforming room, and the preforming room is the enclosure space, if indoor air conditioner heat transfer power is not enough, and indoor temperature can continuously rise, further leads to the temperature rise of tablet press.

6. The tabletting chamber has more dust which can block the filter of the fan or the air conditioner, resulting in the reduction of heat exchange power, and the operators need to check and clean frequently. Is not easy to maintain and clean, and is easy to have maintenance problems.

7. The heat exchange efficiency of cooling air and common air and metal is low, and the cooling air and the common air are limited by the internal mechanical structure of the equipment, so that the air cannot reach or has large wind resistance, and the problem of cooling dead angles exists. The heat dissipation effect is not good.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: overcome prior art's not enough, provide one kind and be applied to rotary tablet press production process heat sink, realize the efficient heat exchange, reduce the temperature of rotary tablet press when continuous operation, reduce the temperature of tablet product.

The invention relates to a cooling device applied to the production process of a rotary tablet press, which comprises a main shaft, wherein the main shaft is arranged on a working cylinder body and is connected with a reduction gearbox; a turret is arranged above the main shaft, an upper die and a lower die are arranged in a hole of the turret, and the upper die and the lower die reciprocate in the hole in the vertical direction; a circulating cooling sleeve is arranged in the main shaft, a main shaft threaded sleeve is arranged above the circulating cooling sleeve, the lower part of the circulating cooling sleeve is inserted into the water inlet and return joint assembly, and the main shaft, the circulating cooling sleeve, the main shaft threaded sleeve and the turret are coaxial; the water inlet and return joint component comprises a water inlet and return joint, the water inlet and return joint is installed on the main shaft, the upper part of the water inlet and return joint is connected with the circulating cooling jacket, a rotary joint is arranged below the water inlet and return joint, the inlet of the rotary joint is provided with two ports which are respectively connected to a water inlet pipe and a water return pipe, and the outlet of the rotary joint is provided with two ports which respectively correspond to the flow direction of inlet water and the flow direction of outlet water.

The special structure is designed, so that the cooling liquid directly exchanges heat with the key part with the largest heat productivity, no refrigeration dead angle is formed, and the cooling effect is better. Effectively improve the tablet press performance, promote the stability of equipment when long-time production to make the machine can be applicable to the preforming production of heat sensitive material, guarantee tablet production process safety. And a sealing device is designed to prevent cooling liquid from entering the turret area and polluting medicines. The cooling liquid acts on the main shaft, and even if water leakage occurs, the water can enter the transmission area due to gravity. The cooling liquid has no possibility of being in direct contact with the medicine, so that the risk of quality problems of the medicine is avoided.

Preferably, the water inlet pipe and the water return pipe are connected with a water cooler, the water outlet of the water cooler is connected with the water inlet pipe, and the water inlet of the water cooler is connected with the water return pipe.

The water chiller is used for preparing cooling liquid.

Preferably, the water chiller uses purified water as the circulating coolant.

The purified water is used as the cooling liquid, so that the price is low, the replacement is convenient, the pollution risk is avoided, and the cost of the refrigeration unit is effectively reduced.

Preferably, install the encoder subassembly on the main shaft, the encoder subassembly includes encoder and hold-in range, and driving pulley and driven pulley are connected to the hold-in range, and driving pulley installs on advancing return water joint and main shaft, and driven pulley installs on the encoder.

The design has an encoder transmission device, biases the encoder on one side of the main shaft, and uses synchronous belt transmission to ensure synchronous rotation of the encoder and the main shaft. The normal function of the encoder is maintained while the positions of the cooling liquid inlet and outlet are reserved.

Preferably, a tension pulley is arranged between the driving pulley and the driven pulley.

Used for adjusting the tension degree of the driving pulley and the driven pulley.

Preferably, the encoder subassembly below is provided with the detection subassembly that leaks, and the detection subassembly that leaks includes water receiving box and level sensor, and water receiving box fixed mounting is in rotary joint's below, and level sensor installs at the water receiving box middle part.

Has the functions of leakage collection and alarm.

Compared with the prior art, the invention has the following beneficial effects:

the cooling device applied to the production process of the rotary tablet press is designed with a special structure, so that cooling liquid directly exchanges heat with a key part with the largest heat productivity, no refrigeration dead angle exists, and the cooling effect is good. Effectively improve the tablet press performance, promote the stability of equipment when long-time production to make the machine can be applicable to the preforming production of heat sensitive material, safe to tablet production. And a sealing device is designed to prevent cooling liquid from entering the turret area and polluting medicines. The cooling liquid acts on the main shaft, and even if water leakage occurs, the water can enter the transmission area due to gravity. The cooling liquid has no possibility of being in direct contact with the medicine, so that the risk of quality problems of the medicine is avoided.

Drawings

FIG. 1 is a schematic view of a cooling structure of a fan according to the background art of the present invention;

FIG. 2 is a schematic structural diagram of an air conditioner for cooling according to the background art of the present invention;

FIG. 3 is a schematic structural diagram of a cooling device applied to a rotary tablet press in a production process;

FIG. 4 is a schematic view of the water inlet and return fitting assembly of the present invention;

fig. 5 is a schematic diagram of an exploded structure of an encoder assembly according to the present invention.

Wherein: 10. a water chiller; 11. a water outlet; 12. a water inlet; 21. a turret; 22. a main shaft thread bushing; 23. a main shaft; 24. a circulating cooling jacket; 25. an upper die; 26. a lower die; 27. a working cylinder body; 28. a reduction gearbox; 30. a water inlet and return joint assembly; 31. a water inlet and return joint; 32. the flow direction of inlet water; 33. the flow direction of the effluent; 34. a rotary joint; 35. a water inlet pipe; 36. a water return pipe; 40. an encoder assembly; 41. a first mounting member; 42. a second mount; 43. an encoder; 44. a driving pulley; 45. a synchronous belt; 46. a driven pulley; 47. a tension wheel; 48. a connecting member; 50. a water leakage detection assembly; 51. a water receiving box; 52. a liquid level sensor; 91. an air conditioner; 92. a heat sink; 93. cold air circulation; 94. an air intake fan; 95. an exhaust fan.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Example 1

As shown in fig. 2-5, the cooling device applied to the production process of the rotary tablet press comprises a main shaft 23, wherein the main shaft 23 is arranged on a working cylinder body 27 and is connected with a reduction gearbox 28; a turret 21 is arranged above the main shaft 23, an upper die 25 and a lower die 26 are arranged in a hole of the turret 21, and the upper die 25 and the lower die 26 reciprocate in the hole in the vertical direction; a circulating cooling jacket 24 is arranged in the main shaft 23, a main shaft threaded sleeve 22 is arranged above the circulating cooling jacket 24, the lower part of the circulating cooling jacket 24 is inserted into the water inlet and return joint assembly 30, and the main shaft 23, the circulating cooling jacket 24, the main shaft threaded sleeve 22 and the turret 21 are coaxial; the water inlet and return joint assembly 30 comprises a water inlet and return joint 31, the water inlet and return joint 31 is installed on the main shaft 23, the upper part of the water inlet and return joint 31 is connected with the circulating cooling jacket 24, a rotary joint 34 is installed below the water inlet and return joint 31, two ports are formed in the inlet of the rotary joint 34 and are respectively connected to a water inlet pipe 35 and a water return pipe 36, and two ports are formed in the outlet of the rotary joint 34 and respectively correspond to a water inlet flow direction 32 and a water outlet flow direction 33.

The special structure is designed, so that the cooling liquid directly exchanges heat with the key part with the largest heat productivity, no refrigeration dead angle is formed, and the cooling effect is better. Effectively improve the tablet press performance, promote the stability of equipment when long-time production to make the machine can be applicable to the preforming production of heat sensitive material, safe to tablet production. And a sealing device is designed to prevent cooling liquid from entering the turret area and polluting medicines. The cooling liquid acts on the main shaft, and even if water leakage occurs, the water can enter the transmission area due to gravity. The cooling liquid has no possibility of being in direct contact with the medicine, so that the risk of quality problems of the medicine is avoided. The cold water directly acts on the working form of the main shaft 23, but not acts on the turret 21 or other parts, and the cold water circulating structure inside the main shaft 23, namely the water inlet and return structures of the main shaft 23, the main shaft threaded sleeve 22 and the circulating cooling sleeve 24.

During normal operation, the reduction gearbox 28 rotates the main shaft 23, as shown in figure 3. The main shaft 23 is rigidly connected to the turret 21, and a plurality of sets of upper and lower molds 25 and 26 are mounted on the turret 21, and the upper and lower molds 25 and 26 are continuously and vertically reciprocally displaced in the holes during the operation of rotating the turret 21.

The main shaft 23 is internally provided with a circulating cooling jacket 24 which is rigidly connected through bolts. The upper part of the main shaft is provided with a main shaft thread sleeve 22 which plays the roles of sealing cold water and increasing heat exchange area. The lower portion of the recirculating cooling jacket 24 is inserted into the return water fitting assembly 30. Wherein the main shaft 23, the circulating cooling jacket 24, the main shaft threaded sleeve 22 and the turret 21 are coaxial. The cold water is directly applied to the machine spindle 23, above which is located the turret 21, below which is located the reduction gearbox 28, and all of which are metal connections. Both the turret 21 and the reduction gearbox 28 are distinct heating elements and therefore there is no cooling dead angle problem.

As shown in FIG. 4, the water inlet and return joint assembly 30 and the water inlet and return joint 31 are installed on the main shaft 23 and are connected with the circulating cooling jacket 24 through threads. The water inlet and return joint 31 rotates together with the main shaft 23. Below, an encoder assembly 40 is mounted, the encoder assembly 40 remaining stationary. The rotary joint 34 is arranged at the lower part, the inlet of the rotary joint 34 is provided with two ports which are respectively connected with the water inlet pipe 35 and the water return pipe 36, the outlet of the rotary joint 34 is provided with two ports which respectively correspond to the water inlet flow direction 32 and the water outlet flow direction 33, and the rotary joint 34 is static.

Furthermore, the water inlet pipe 35 and the water return pipe 36 are connected with the water cooler 10, the water outlet 11 of the water cooler 10 is connected with the water inlet pipe 35, and the water inlet 12 of the water cooler 10 is connected with the water return pipe 36.

The water chiller 10 transfers the exchanged heat to the water chiller 10 through a hot and cold water circulation. Only two pipelines are arranged between the tablet press and the water cooler 10, and the pipelines are sealed in the whole working engineering, so that the problem of dust pollution is solved. The water chiller 10 is placed in an auxiliary machinery room, and is in a dust-free environment, so that problems such as blockage are avoided. The modes of air exhaust, air conditioning and the like can be added in the auxiliary machinery room to realize heat exchange.

Further, the water chiller 10 uses purified water as a circulating coolant.

The purified water is used as the cooling liquid, so that the price is low, the replacement is convenient, the pollution risk is avoided, and the cost of the refrigeration unit is effectively reduced. Purified water is used as the cooling liquid without using other media such as cooling oil. Since purified water is a safe medium for pharmaceutical factory production, there is no risk of contamination, and it meets GMP requirements.

The temperature of the cooling liquid can be about 5 ℃ generally, compared with the room temperature of 20 ℃, the temperature difference is large, cold water is in direct contact with a metal surface and acts on the core heating element, the heat dissipation efficiency is high, and the effect is good.

During the working process of the tablet press, information such as the rotating position and angle of the main shaft 23 needs to be detected, the detection accuracy is high, and if a coaxial encoder is not adopted or an encoder 43 is installed at other positions, the detection accuracy of the main shaft 23 may be affected. The advanced detection method in the industry at present is to directly mount the encoder 43 below the main shaft 23, the input shaft of the encoder 43 is coaxial with the main shaft 23, the main shaft 23 rotates during the working process, and the encoder 43 does not rotate.

As shown in fig. 5, because the spindle water cooling function is added, it is necessary to ensure that the spindle 23 and the water inlet and return joint 31 and the rotary joint 34 are coaxial. During the operation of the tablet press, the main shaft 23 and the water inlet and return joint 31 are rotating, and the rotating joint 34 is static. And thus there is no installation space for the encoder 43. Under the prerequisite that satisfies water-cooling input/output function, arrange the encoder biasing, use the hold-in range to drive encoder and main shaft synchronous rotation simultaneously, solved the problem that water cooling plant and encoder interfered, the maximize reduces the error influence that the encoder 43 biasing brought simultaneously.

Specifically, install encoder subassembly 40 on the main shaft 23, encoder subassembly 40 includes encoder 43 and hold-in range 45, and drive pulley 44 and driven pulley 46 are connected to hold-in range 45, and drive pulley 44 is installed on advancing return water joint 31 and main shaft 23, and driven pulley 46 installs on encoder 43. A tension pulley 47 is arranged between the driving pulley 44 and the driven pulley 46. The water inlet-return joint 31 and the driving pulley 44 are relatively static and fixedly connected with each other through a mechanical structure. The driven pulley 46 and the encoder 43 are relatively stationary and are fixedly connected by mechanical means. The number of teeth of the driving pulley 44 and the driven pulley 46 is the same. A tension wheel 47 is arranged in the middle, and the position of the tension wheel can be adjusted.

The operating principle of the encoder assembly 40 is: the water inlet and return joint 31 and the main shaft 23 are relatively static, and a driving belt wheel 44 is arranged on the upper surface of the water inlet and return joint, the driving belt wheel 44 drives a driven belt wheel 46 through a synchronous belt 45, and the driven belt wheel is directly connected with an input shaft of an encoder 43. The synchronization of the rotation of the main shaft 23 and the rotation of the encoder 43 is completed.

An encoder transmission device is designed, the encoder 43 is biased to one side of the main shaft 23, and the synchronous belt 45 is used for transmission, so that the encoder 43 and the main shaft 23 can synchronously rotate. The normal function of the encoder 43 is preserved while leaving the coolant inlet and outlet locations.

Here, the timing belt 45, the driving pulley 44, and the driven pulley 46 are mounted by the second mount 42 and the first mount 41.

Further, a water leakage detection assembly 50 is arranged below the encoder assembly 40, the water leakage detection assembly 50 comprises a water receiving box 51 and a liquid level sensor 52, the water receiving box 51 is fixedly installed below the rotary joint 34, and the liquid level sensor 52 is installed in the middle of the water receiving box 51.

Has the functions of leakage collection and alarm. A water receiving box 51 is arranged below the rotary joint 34, and a liquid level sensor 52 is arranged in the water receiving box 51. When the rotary joint 34 is damaged and water leakage occurs, the liquid level sensor 52 will detect the signal and transmit the signal to the PLC, so as to implement the alarm shutdown function.

The invention relates to a cooling device applied to the production process of a rotary tablet press, which has the following working principle:

overall, cold water machine 10 makes cold water, is connected to the tablet press inside through delivery port 11 and inlet tube 35, through the internal circulation, with heat exchange completion back hot water, in 36 retransferring meeting cold water machine 10 through the wet return, the cold water machine is through inside work, with the hot water of intaking, reduces cold water again. And thus are continually cycled.

Inside the tablet press, a water inlet pipe 35 and a water return pipe 36 are connected to the water inlet and return joint assembly 30, and cool water is circulated through this assembly into the tablet press main shaft 23 and the circulating cooling jacket 24. The heat exchange is achieved by direct contact of the cold water with the metal surface of the spindle 23. The direct cooling of the main shaft 23 is realized.

Inside the tablet press, the main shaft 23 and the turret 21 are in direct contact, and the turret 21 is cooled by heat exchange at the contact surfaces, so that the punches, i.e., the upper die 25 and the lower die 26 are cooled, and the tablets are cooled. Because the heat conductivity coefficient of metal is higher, and the temperature of cold water is low enough, so the heat transfer efficiency and the cooling effect of the whole system to the tablet press and the die are very obvious.

The invention relates to a cooling device applied to the production process of a rotary tablet press, which comprises the following working processes:

the external water chiller 10 produces cold water, the cold water is conveyed into the machine through a rotary joint 34 along a water inlet pipe 35, the cold water is conveyed into a cavity between the main shaft 23 and the circulating cooling jacket 24 along a water inlet flow direction 32, the cavity is filled with the cold water and completes heat exchange with the main shaft 23, and the hot water after the heat exchange is completed enters an internal thin pipe of the circulating cooling jacket 24 through the main shaft threaded sleeve 22. The hot water in the inner tubules flows down through the water inlet and return joint 31 in the water outlet flow direction 33 into the swivel joint 34. Finally, the hot water enters the water cooler 10 through the rotary joint 34 and the return pipe 36, and finally the whole circulation process is completed. In the production process, cold water continuously enters, and hot water continuously flows out. The temperature of the cold water is low, the contact area of the cold water and the main shaft is large, the heat exchange efficiency is high, the main shaft is in direct contact with the reduction gearbox, the turret and the die through metal surfaces, and the heat conduction coefficient is high. Therefore, the heat dissipation power is very high, the temperature of a heat source is effectively controlled, the temperatures of the die and the turret are reduced, the production temperature of the medicine is further ensured, and the quality of the medicine is ensured.

Claims

1. The cooling device applied to the production process of the rotary tablet press is characterized by comprising a main shaft (23), wherein the main shaft (23) is arranged on a working cylinder body (27) and is connected with a reduction gearbox (28); a turret (21) is arranged above the main shaft (23), an upper die (25) and a lower die (26) are arranged in a hole of the turret (21), and the upper die (25) and the lower die (26) are displaced in a reciprocating manner in the vertical direction in the hole; a circulating cooling jacket (24) is arranged in the main shaft (23), a main shaft threaded sleeve (22) is arranged above the circulating cooling jacket (24), the lower part of the circulating cooling jacket (24) is inserted into the water inlet and return joint assembly (30), and the main shaft (23), the circulating cooling jacket (24), the main shaft threaded sleeve (22) and the turret (21) are coaxial; advance return water and connect subassembly (30) including advancing return water and connect (31), advance return water and connect (31) and install on main shaft (23), advance return water and connect (31) upper portion and circulative cooling cover (24) and be connected, advance return water and connect (31) below and be equipped with rotary joint (34), rotary joint (34) import has two mouths, is connected to inlet tube (35) and recovery tube (36) respectively, rotary joint (34) export has two mouths, corresponds respectively and advances water flow direction (32) and play water flow direction (33).

2. The cooling device applied to the production process of the rotary tablet press according to claim 1, wherein the water inlet pipe (35) and the recovery pipe (36) are connected with the water cooler (10), the water outlet (11) of the water cooler (10) is connected with the water inlet pipe (35), and the water inlet (12) of the water cooler (10) is connected with the recovery pipe (36).

3. The cooling device applied to the production process of a rotary tablet press according to claim 2, wherein the water chiller (10) uses purified water as the circulating cooling fluid.

4. The cooling device applied to the production process of the rotary tablet press according to any one of claims 1 to 3, wherein the main shaft (23) is provided with an encoder assembly (40), the encoder assembly (40) comprises an encoder (43) and a synchronous belt (45), the synchronous belt (45) is connected with a driving pulley (44) and a driven pulley (46), the driving pulley (44) is arranged on the water inlet and return joint (31) and the main shaft (23), and the driven pulley (46) is arranged on the encoder (43).

5. The cooling device applied to the production process of a rotary tablet press according to claim 4, wherein a tension wheel (47) is installed between the driving pulley (44) and the driven pulley (46).

6. The temperature reducing device applied to the rotary tablet press in the production process is characterized in that a water leakage detection assembly (50) is arranged below the encoder assembly (40), the water leakage detection assembly (50) comprises a water receiving box (51) and a liquid level sensor (52), the water receiving box (51) is fixedly arranged below the rotary joint (34), and the liquid level sensor (52) is arranged in the middle of the water receiving box (51).