CN114052878A - Ultrathin anterior cervical biological titanium plate and preparation method thereof - Google Patents
Ultrathin anterior cervical biological titanium plate and preparation method thereof Download PDFInfo
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- CN114052878A CN114052878A CN202111388903.8A CN202111388903A CN114052878A CN 114052878 A CN114052878 A CN 114052878A CN 202111388903 A CN202111388903 A CN 202111388903A CN 114052878 A CN114052878 A CN 114052878A
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims abstract description 113
- 229910052719 titanium Inorganic materials 0.000 title claims abstract description 113
- 239000010936 titanium Substances 0.000 title claims abstract description 113
- 238000002360 preparation method Methods 0.000 title claims description 7
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 35
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 27
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 24
- 238000004381 surface treatment Methods 0.000 claims abstract description 15
- 230000004071 biological effect Effects 0.000 claims abstract description 7
- 238000005507 spraying Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000004506 ultrasonic cleaning Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000005498 polishing Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 238000004080 punching Methods 0.000 claims description 4
- 238000005488 sandblasting Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 229910052593 corundum Inorganic materials 0.000 claims description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 238000002513 implantation Methods 0.000 description 8
- 239000007943 implant Substances 0.000 description 6
- 230000010354 integration Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 210000002449 bone cell Anatomy 0.000 description 4
- 230000008468 bone growth Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 208000019505 Deglutition disease Diseases 0.000 description 2
- 206010013952 Dysphonia Diseases 0.000 description 2
- 208000010473 Hoarseness Diseases 0.000 description 2
- 206010058522 Oesophageal injury Diseases 0.000 description 2
- 206010051867 Tracheal injury Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010050296 Intervertebral disc protrusion Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000007849 functional defect Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
- 230000007847 structural defect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8061—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates specially adapted for particular bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7059—Cortical plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P15/00—Making specific metal objects by operations not covered by a single other subclass or a group in this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Prostheses (AREA)
Abstract
The invention relates to an ultrathin anterior cervical biological titanium plate which is characterized in that: the thickness of the titanium plate is 1.5mm, the titanium plate is designed to be low in thickness and low in notch, hydroxyapatite surface treatment is carried out on the bone contact surface of the titanium plate, and the hydroxyapatite surface treatment is provided for the titanium plate to have biological activity.
Description
Technical Field
The invention relates to an ultrathin anterior cervical biological titanium plate and a preparation method thereof.
Background
An anterior cervical titanium plate is a surgical implant for assisting the fusion of cervical vertebrae and internal fixation of the anterior cervical vertebrae, can be combined with an anterior cervical screw and an intervertebral fusion device for use, and is widely applied to the surgical treatment of cervical spondylosis, cervical disc herniation, cervical vertebra infection, cervical vertebra tumor, cervical vertebra deformity and other diseases. The existing anterior cervical titanium plate is generally formed by combining an anterior titanium plate and a locking plate, and has the advantages of simple and convenient processing, short development period, high clinical application degree and the like.
Although the above mentioned anterior cervical titanium plate is satisfactory for general surgical use, it is found in practical clinical application that it still has structural and functional disadvantages. These problems cause the anterior cervical titanium plate not to be used optimally in practical applications. The disadvantages can be summarized as follows:
1. has no bone ingrowth property and poor stability.
The existing anterior cervical titanium plate is mainly made of titanium alloy, does not have osteoconductivity, osteoinduction and osseointegration, is poorly integrated with surrounding bone tissues after being implanted, and has hidden troubles in long-term stability. Meanwhile, after the traditional titanium plate is processed by surface treatment, polishing treatment, anodic oxidation coloring treatment and the like, although the surface smoothness is improved, the friction coefficient between the titanium plate and the contacted bone tissue is reduced, the early stability is provided only by the thickness of the titanium plate and the acting force of a screw, the titanium plate is easy to loosen and shift, and the stability after implantation is not maintained.
2. The incisional wound is too high, which is easy to damage the surrounding tissues and increases the incidence of complications.
Although the occurrence of screw backing, falling-off, titanium plate displacement and failure is effectively reduced after the existing anterior cervical way titanium plate and locking plate are assembled, the average actual thickness of the titanium plate is mostly over 2.2mm and too thick, and the titanium plate can be caused to be cut too high along with the increase of the thickness, so that the titanium plate stimulates surrounding important tissues and organs, thereby causing implant-related complications such as dysphagia, hoarseness, esophageal injury, tracheal injury and the like.
Therefore, the aforesaid anterior cervical titanium plate still has considerable structural and functional defects, and needs to be improved. However, most of the improvement on the anterior cervical titanium plate at the present stage focuses on how to improve the locking capability and increase the initial stability of the anterior cervical titanium plate, and the problems of insufficient bone ingrowth performance, poor bone integration performance, too thick thickness, too high incisura and the like of the anterior cervical titanium plate are rarely researched.
Disclosure of Invention
The invention provides an ultrathin anterior cervical biological titanium plate and a preparation method thereof, which can reduce the occurrence of related complications of an implant while being firmly locked, so that the bone growth effect and excellent bone integration performance of the titanium plate are provided, the stability after implantation is improved, the implantation is more convenient and flexible, and the requirements of various operations are met.
In order to achieve the purpose, the invention adopts the technical scheme that:
the utility model provides an ultra-thin anterior cervical way biotype titanium plate which characterized in that: the thickness of the titanium plate is only 1.5mm, the titanium plate is designed to be low in thickness and low in notch, the back surface of the titanium plate is a bone contact surface, hydroxyapatite surface treatment is carried out, and the hydroxyapatite surface treatment is used for enabling the titanium plate to have biological activity.
A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
and 4, assembling the titanium plate sprayed with the hydroxyapatite and the locking plate, and carrying out ultrasonic cleaning, drying and sterilizing treatment.
The invention has the beneficial effects that: compared with the traditional titanium plate with the average thickness of more than 2.2mm, the titanium plate has the thickness of only 1.5mm, has ultrathin thickness and ultralow incisional marks, can effectively reduce the damage of the titanium plate to surrounding tissues such as esophagus and trachea, reduces the occurrence of related complications of implants, has better biological activity, is subjected to hydroxyapatite surface treatment on the contact surface with bone tissues to endow the bone tissue with good bone conduction, bone induction, bone integration and bone growth performance, is convenient for bone cells to grow to form stable titanium plate-bone interface fixation, increases the stability after implantation, adopts the traditional method to manufacture a brand-new ultrathin anterior cervical vertebra biological titanium plate, has simple, easy, convenient and effective manufacturing method, can be applied to various anterior cervical vertebra surgeries, simplifies the surgical operation, improves the surgical effect and simultaneously reduces the occurrence of complications.
Drawings
Fig. 1 is a rear perspective view of the ultra-thin anterior cervical biotype titanium plate.
Fig. 2 is a front perspective structure view of the ultra-thin anterior cervical biotype titanium plate.
Fig. 3 is a rear plane structure view of the ultra-thin anterior cervical biotype titanium plate.
FIG. 4 is a sectional view of the ultra-thin anterior cervical biotype titanium plate taken along line A-A.
Fig. 5 is a front plane structure view of the ultra-thin anterior cervical biotype titanium plate.
Description of reference numerals: 1-a titanium plate; 2-hydroxyapatite; 3-locking plate.
Detailed Description
As shown in fig. 1 to 5, the ultrathin anterior cervical biotype titanium plate is characterized in that: the thickness of the titanium plate 1 is 1.5mm, the titanium plate 1 is designed to be low in thickness and low in notch, the back face of the titanium plate 1 is a bone contact face, hydroxyapatite 2 is subjected to surface treatment, and the hydroxyapatite 2 is subjected to surface treatment to enable the titanium plate 1 to have biological activity.
2. A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
and 4, assembling the titanium plate 1 sprayed with the hydroxyapatite 2 and the locking plate 3, and performing ultrasonic cleaning, drying and sterilization treatment.
In the embodiment, the raw material of the titanium plate 1 is TA3, the raw material of the locking plate 2 is TC4, the design drawing is shown in the figures 1-3, the titanium plate 1 is designed to be ultra-thin and ultra-low in notch, the appearance is processed and sketched through blanking, an opposite sex groove and an inverted opposite sex groove angle, then chamfering, profiling and punching are carried out, the titanium plate 1 and the locking plate 2 matched with the titanium plate 1 are preliminarily designed and manufactured, the thickness of the titanium plate 1 is only 1.5mm, the titanium plate 1 is polished through 360-mesh 1500-mesh metallographic abrasive paper, the titanium plate 1 is washed with distilled water after polishing, and the titanium plate 1 is washed with Al after washing2O3The method comprises the following steps of performing sand blasting on the titanium plate 1, and finally performing ultrasonic cleaning on the titanium plate 1 in ethanol, wherein the process is to improve the average roughness of the surface of the titanium plate 1, the back surface of the titanium plate 1 is a bone contact surface, so that the bone contact surface of the titanium plate 1 can be better combined with hydroxyapatite 2, the bonding strength of a coating and the bone contact surface of the titanium plate 1 in a subsequent spraying process is improved, and the method is better suitable for surface treatment of the hydroxyapatite 2. Spraying the bone contact surface of the titanium plate 1 by using atmospheric plasma equipment, setting the power of the atmospheric plasma equipment to be 81kW, setting the current to be 530A, setting the spraying distance to be 90mm, spraying the hydroxyapatite 2 on the bone contact surface of the titanium plate 1, performing surface treatment on the hydroxyapatite 2 to provide better biological activity for the titanium plate 1, wherein the atmospheric plasma spraying method is a method for forming molten particles by melting and spraying a powder material by using an ultrahigh-temperature (more than 8000K) plasma arc and impacting the bone contact surface of the titanium plate 1 at a higher speed to form a coating, and the biological coating prepared by the method has a porous structureAnd bone cells can grow into the titanium plate 1 to form stable bone interface fixation, after spraying, the titanium plate 1 and the locking plate 3 are assembled and are subjected to ultrasonic cleaning, drying and sterilization together.
The invention has ultra-thin thickness and ultra-low incisure process, the thickness of the titanium plate 1 is only 1.5mm, compared with the thickness exceeding 2mm and the ultra-high incisure of the traditional titanium plate, the titanium plate 1 can effectively reduce the friction between the titanium plate and the surrounding tissues and reduce the occurrence of the complications related to the implant, such as: dysphagia, hoarseness, esophageal injury and tracheal injury, but in general, if the thickness of the anterior cervical titanium plate is reduced, the stability after implantation is influenced, so that the local stability is reduced, even the titanium plate is displaced and fails, therefore, the thickness of the titanium plate 1 is reduced, the surface treatment of the hydroxyapatite 2 is carried out on the bone contact surface of the titanium plate, the surface treatment of the hydroxyapatite 2 can obviously increase the friction coefficient of the bone tissue contact surface of the titanium plate 1, the initial stability after implantation is increased, most importantly, the hydroxyapatite 2 can endow the titanium plate 1 with better bone conductivity, bone inductivity, bone integration and bone growth performance, thereby facilitating the bone cells to grow into and form stable bone interface fixation of the titanium plate 1-bone, and obviously improving the middle and later period stability of the titanium plate 1 after implantation, the probability of the titanium plate 1 being displaced and failing is significantly reduced.
The invention has the advantages that:
compared with the traditional titanium plate with the average thickness of more than 2.2mm, the titanium plate provided by the invention has the thickness of only 1.5mm, has ultrathin thickness and ultralow incisional trace, can effectively reduce friction between the titanium plate and surrounding tissues such as esophagus and trachea, reduces the occurrence of related complications of implants, has better biological activity, is subjected to hydroxyapatite surface treatment on the contact surface with bone tissues, and has good bone conduction, bone induction, bone integration and bone growth performances, so that bone cells can grow to form stable titanium plate-bone interface fixation, the post-implantation stability is increased, a brand new ultrathin anterior cervical vertebra biological titanium plate is manufactured by adopting a traditional method, the manufacturing method is simple, feasible, convenient and effective, and the manufactured product can be applied to various anterior cervical vertebra surgeries, the surgical operation is simplified, the surgical effect is improved, and the occurrence of complications is reduced.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (2)
1. The utility model provides an ultra-thin anterior cervical way biotype titanium plate which characterized in that: the thickness of the titanium plate (1) is 1.5mm, the titanium plate (1) is designed to be low in thickness and low in notch, the back face of the titanium plate (1) is a bone contact face, hydroxyapatite (2) is subjected to surface treatment, and the hydroxyapatite (2) is subjected to surface treatment to enable the titanium plate (1) to have biological activity.
2. A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
step 1, taking TA3 and TC4 as raw materials, processing and outlining through blanking, an opposite sex groove and an opposite sex groove angle, and then preliminarily designing and manufacturing a titanium plate (1) with the thickness of only 1.5mm and a matched locking plate (3) through chamfering, profiling and punching;
step 2, polishing the surface of the titanium plate (1) by using 360-1500-mesh metallographic abrasive paper, cleaning the surface of the titanium plate (1) by using distilled water, and finally using Al2O3Carrying out ultrasonic cleaning in ethanol after carrying out sand blasting on the surface of the titanium plate (1);
step 3, spraying hydroxyapatite (2) on a bone contact surface on the back of the titanium plate (1) by using atmospheric plasma equipment, setting the power to be 81kW, the current to be 530A and the spraying distance to be 90 mm;
and 4, assembling the titanium plate (1) sprayed with the hydroxyapatite (2) and the locking plate (3), and performing ultrasonic cleaning, drying and sterilization treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388903.8A CN114052878A (en) | 2021-11-22 | 2021-11-22 | Ultrathin anterior cervical biological titanium plate and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388903.8A CN114052878A (en) | 2021-11-22 | 2021-11-22 | Ultrathin anterior cervical biological titanium plate and preparation method thereof |
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| Publication Number | Publication Date |
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| CN114052878A true CN114052878A (en) | 2022-02-18 |
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| CN202111388903.8A Pending CN114052878A (en) | 2021-11-22 | 2021-11-22 | Ultrathin anterior cervical biological titanium plate and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212348A (en) * | 2022-06-20 | 2022-10-21 | 四川大学 | PEEK-based composite implant and preparation method and application thereof |
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| CN115212348A (en) * | 2022-06-20 | 2022-10-21 | 四川大学 | PEEK-based composite implant and preparation method and application thereof |
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Application publication date: 20220218 |