CN114052878A - Ultrathin anterior cervical biological titanium plate and preparation method thereof - Google Patents

Ultrathin anterior cervical biological titanium plate and preparation method thereof Download PDF

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Publication number
CN114052878A
CN114052878A CN202111388903.8A CN202111388903A CN114052878A CN 114052878 A CN114052878 A CN 114052878A CN 202111388903 A CN202111388903 A CN 202111388903A CN 114052878 A CN114052878 A CN 114052878A
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titanium plate
hydroxyapatite
plate
anterior cervical
thickness
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王新涛
周长龙
刘大千
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Harbin Medical University
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Harbin Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8061Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates specially adapted for particular bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7059Cortical plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B23MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23PMETAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
    • B23P15/00Making specific metal objects by operations not covered by a single other subclass or a group in this subclass
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to an ultrathin anterior cervical biological titanium plate which is characterized in that: the thickness of the titanium plate is 1.5mm, the titanium plate is designed to be low in thickness and low in notch, hydroxyapatite surface treatment is carried out on the bone contact surface of the titanium plate, and the hydroxyapatite surface treatment is provided for the titanium plate to have biological activity.

Description

Ultrathin anterior cervical biological titanium plate and preparation method thereof
Technical Field
The invention relates to an ultrathin anterior cervical biological titanium plate and a preparation method thereof.
Background
An anterior cervical titanium plate is a surgical implant for assisting the fusion of cervical vertebrae and internal fixation of the anterior cervical vertebrae, can be combined with an anterior cervical screw and an intervertebral fusion device for use, and is widely applied to the surgical treatment of cervical spondylosis, cervical disc herniation, cervical vertebra infection, cervical vertebra tumor, cervical vertebra deformity and other diseases. The existing anterior cervical titanium plate is generally formed by combining an anterior titanium plate and a locking plate, and has the advantages of simple and convenient processing, short development period, high clinical application degree and the like.
Although the above mentioned anterior cervical titanium plate is satisfactory for general surgical use, it is found in practical clinical application that it still has structural and functional disadvantages. These problems cause the anterior cervical titanium plate not to be used optimally in practical applications. The disadvantages can be summarized as follows:
1. has no bone ingrowth property and poor stability.
The existing anterior cervical titanium plate is mainly made of titanium alloy, does not have osteoconductivity, osteoinduction and osseointegration, is poorly integrated with surrounding bone tissues after being implanted, and has hidden troubles in long-term stability. Meanwhile, after the traditional titanium plate is processed by surface treatment, polishing treatment, anodic oxidation coloring treatment and the like, although the surface smoothness is improved, the friction coefficient between the titanium plate and the contacted bone tissue is reduced, the early stability is provided only by the thickness of the titanium plate and the acting force of a screw, the titanium plate is easy to loosen and shift, and the stability after implantation is not maintained.
2. The incisional wound is too high, which is easy to damage the surrounding tissues and increases the incidence of complications.
Although the occurrence of screw backing, falling-off, titanium plate displacement and failure is effectively reduced after the existing anterior cervical way titanium plate and locking plate are assembled, the average actual thickness of the titanium plate is mostly over 2.2mm and too thick, and the titanium plate can be caused to be cut too high along with the increase of the thickness, so that the titanium plate stimulates surrounding important tissues and organs, thereby causing implant-related complications such as dysphagia, hoarseness, esophageal injury, tracheal injury and the like.
Therefore, the aforesaid anterior cervical titanium plate still has considerable structural and functional defects, and needs to be improved. However, most of the improvement on the anterior cervical titanium plate at the present stage focuses on how to improve the locking capability and increase the initial stability of the anterior cervical titanium plate, and the problems of insufficient bone ingrowth performance, poor bone integration performance, too thick thickness, too high incisura and the like of the anterior cervical titanium plate are rarely researched.
Disclosure of Invention
The invention provides an ultrathin anterior cervical biological titanium plate and a preparation method thereof, which can reduce the occurrence of related complications of an implant while being firmly locked, so that the bone growth effect and excellent bone integration performance of the titanium plate are provided, the stability after implantation is improved, the implantation is more convenient and flexible, and the requirements of various operations are met.
In order to achieve the purpose, the invention adopts the technical scheme that:
the utility model provides an ultra-thin anterior cervical way biotype titanium plate which characterized in that: the thickness of the titanium plate is only 1.5mm, the titanium plate is designed to be low in thickness and low in notch, the back surface of the titanium plate is a bone contact surface, hydroxyapatite surface treatment is carried out, and the hydroxyapatite surface treatment is used for enabling the titanium plate to have biological activity.
A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
step 1, taking TA3 and TC4 as raw materials, processing and outlining through blanking, an opposite sex groove and an opposite sex groove angle, and then preliminarily designing and manufacturing a titanium plate with the thickness of 1.5mm and a matched locking plate through chamfering, profiling and punching;
step 2, polishing the surface of the titanium plate by using metallographic abrasive paper with the size of 360-2O3Carrying out ultrasonic cleaning in ethanol after carrying out sand blasting on the surface of the titanium plate;
step 3, performing hydroxyapatite spraying on the bone contact surface on the back of the titanium plate by using atmospheric plasma equipment, setting the power to be 81kW, the current to be 530A and the spraying distance to be 90 mm;
and 4, assembling the titanium plate sprayed with the hydroxyapatite and the locking plate, and carrying out ultrasonic cleaning, drying and sterilizing treatment.
The invention has the beneficial effects that: compared with the traditional titanium plate with the average thickness of more than 2.2mm, the titanium plate has the thickness of only 1.5mm, has ultrathin thickness and ultralow incisional marks, can effectively reduce the damage of the titanium plate to surrounding tissues such as esophagus and trachea, reduces the occurrence of related complications of implants, has better biological activity, is subjected to hydroxyapatite surface treatment on the contact surface with bone tissues to endow the bone tissue with good bone conduction, bone induction, bone integration and bone growth performance, is convenient for bone cells to grow to form stable titanium plate-bone interface fixation, increases the stability after implantation, adopts the traditional method to manufacture a brand-new ultrathin anterior cervical vertebra biological titanium plate, has simple, easy, convenient and effective manufacturing method, can be applied to various anterior cervical vertebra surgeries, simplifies the surgical operation, improves the surgical effect and simultaneously reduces the occurrence of complications.
Drawings
Fig. 1 is a rear perspective view of the ultra-thin anterior cervical biotype titanium plate.
Fig. 2 is a front perspective structure view of the ultra-thin anterior cervical biotype titanium plate.
Fig. 3 is a rear plane structure view of the ultra-thin anterior cervical biotype titanium plate.
FIG. 4 is a sectional view of the ultra-thin anterior cervical biotype titanium plate taken along line A-A.
Fig. 5 is a front plane structure view of the ultra-thin anterior cervical biotype titanium plate.
Description of reference numerals: 1-a titanium plate; 2-hydroxyapatite; 3-locking plate.
Detailed Description
As shown in fig. 1 to 5, the ultrathin anterior cervical biotype titanium plate is characterized in that: the thickness of the titanium plate 1 is 1.5mm, the titanium plate 1 is designed to be low in thickness and low in notch, the back face of the titanium plate 1 is a bone contact face, hydroxyapatite 2 is subjected to surface treatment, and the hydroxyapatite 2 is subjected to surface treatment to enable the titanium plate 1 to have biological activity.
2. A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
step 1, taking TA3 and TC4 as raw materials, processing and outlining through blanking, an opposite sex groove and an opposite sex groove angle, and then preliminarily designing and manufacturing a titanium plate 1 with the thickness of only 1.5mm and a matched locking plate 3 through chamfering, profiling and punching;
step 2, polishing the surface of the titanium plate 1 by using metallographic abrasive paper with the size of 360 meshes and 1500 meshes, washing the surface of the titanium plate 1 by using distilled water, and finally, using Al2O3Carrying out ultrasonic cleaning in ethanol after carrying out sand blasting on the surface of the titanium plate 1;
step 3, spraying hydroxyapatite 2 on the bone contact surface on the back surface of the titanium plate 1 by using atmospheric plasma equipment, setting the power to be 81kW, the current to be 530A and the spraying distance to be 90 mm;
and 4, assembling the titanium plate 1 sprayed with the hydroxyapatite 2 and the locking plate 3, and performing ultrasonic cleaning, drying and sterilization treatment.
In the embodiment, the raw material of the titanium plate 1 is TA3, the raw material of the locking plate 2 is TC4, the design drawing is shown in the figures 1-3, the titanium plate 1 is designed to be ultra-thin and ultra-low in notch, the appearance is processed and sketched through blanking, an opposite sex groove and an inverted opposite sex groove angle, then chamfering, profiling and punching are carried out, the titanium plate 1 and the locking plate 2 matched with the titanium plate 1 are preliminarily designed and manufactured, the thickness of the titanium plate 1 is only 1.5mm, the titanium plate 1 is polished through 360-mesh 1500-mesh metallographic abrasive paper, the titanium plate 1 is washed with distilled water after polishing, and the titanium plate 1 is washed with Al after washing2O3The method comprises the following steps of performing sand blasting on the titanium plate 1, and finally performing ultrasonic cleaning on the titanium plate 1 in ethanol, wherein the process is to improve the average roughness of the surface of the titanium plate 1, the back surface of the titanium plate 1 is a bone contact surface, so that the bone contact surface of the titanium plate 1 can be better combined with hydroxyapatite 2, the bonding strength of a coating and the bone contact surface of the titanium plate 1 in a subsequent spraying process is improved, and the method is better suitable for surface treatment of the hydroxyapatite 2. Spraying the bone contact surface of the titanium plate 1 by using atmospheric plasma equipment, setting the power of the atmospheric plasma equipment to be 81kW, setting the current to be 530A, setting the spraying distance to be 90mm, spraying the hydroxyapatite 2 on the bone contact surface of the titanium plate 1, performing surface treatment on the hydroxyapatite 2 to provide better biological activity for the titanium plate 1, wherein the atmospheric plasma spraying method is a method for forming molten particles by melting and spraying a powder material by using an ultrahigh-temperature (more than 8000K) plasma arc and impacting the bone contact surface of the titanium plate 1 at a higher speed to form a coating, and the biological coating prepared by the method has a porous structureAnd bone cells can grow into the titanium plate 1 to form stable bone interface fixation, after spraying, the titanium plate 1 and the locking plate 3 are assembled and are subjected to ultrasonic cleaning, drying and sterilization together.
The invention has ultra-thin thickness and ultra-low incisure process, the thickness of the titanium plate 1 is only 1.5mm, compared with the thickness exceeding 2mm and the ultra-high incisure of the traditional titanium plate, the titanium plate 1 can effectively reduce the friction between the titanium plate and the surrounding tissues and reduce the occurrence of the complications related to the implant, such as: dysphagia, hoarseness, esophageal injury and tracheal injury, but in general, if the thickness of the anterior cervical titanium plate is reduced, the stability after implantation is influenced, so that the local stability is reduced, even the titanium plate is displaced and fails, therefore, the thickness of the titanium plate 1 is reduced, the surface treatment of the hydroxyapatite 2 is carried out on the bone contact surface of the titanium plate, the surface treatment of the hydroxyapatite 2 can obviously increase the friction coefficient of the bone tissue contact surface of the titanium plate 1, the initial stability after implantation is increased, most importantly, the hydroxyapatite 2 can endow the titanium plate 1 with better bone conductivity, bone inductivity, bone integration and bone growth performance, thereby facilitating the bone cells to grow into and form stable bone interface fixation of the titanium plate 1-bone, and obviously improving the middle and later period stability of the titanium plate 1 after implantation, the probability of the titanium plate 1 being displaced and failing is significantly reduced.
The invention has the advantages that:
compared with the traditional titanium plate with the average thickness of more than 2.2mm, the titanium plate provided by the invention has the thickness of only 1.5mm, has ultrathin thickness and ultralow incisional trace, can effectively reduce friction between the titanium plate and surrounding tissues such as esophagus and trachea, reduces the occurrence of related complications of implants, has better biological activity, is subjected to hydroxyapatite surface treatment on the contact surface with bone tissues, and has good bone conduction, bone induction, bone integration and bone growth performances, so that bone cells can grow to form stable titanium plate-bone interface fixation, the post-implantation stability is increased, a brand new ultrathin anterior cervical vertebra biological titanium plate is manufactured by adopting a traditional method, the manufacturing method is simple, feasible, convenient and effective, and the manufactured product can be applied to various anterior cervical vertebra surgeries, the surgical operation is simplified, the surgical effect is improved, and the occurrence of complications is reduced.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (2)

1. The utility model provides an ultra-thin anterior cervical way biotype titanium plate which characterized in that: the thickness of the titanium plate (1) is 1.5mm, the titanium plate (1) is designed to be low in thickness and low in notch, the back face of the titanium plate (1) is a bone contact face, hydroxyapatite (2) is subjected to surface treatment, and the hydroxyapatite (2) is subjected to surface treatment to enable the titanium plate (1) to have biological activity.
2. A preparation method of an ultrathin anterior cervical biological titanium plate is characterized by comprising the following steps:
step 1, taking TA3 and TC4 as raw materials, processing and outlining through blanking, an opposite sex groove and an opposite sex groove angle, and then preliminarily designing and manufacturing a titanium plate (1) with the thickness of only 1.5mm and a matched locking plate (3) through chamfering, profiling and punching;
step 2, polishing the surface of the titanium plate (1) by using 360-1500-mesh metallographic abrasive paper, cleaning the surface of the titanium plate (1) by using distilled water, and finally using Al2O3Carrying out ultrasonic cleaning in ethanol after carrying out sand blasting on the surface of the titanium plate (1);
step 3, spraying hydroxyapatite (2) on a bone contact surface on the back of the titanium plate (1) by using atmospheric plasma equipment, setting the power to be 81kW, the current to be 530A and the spraying distance to be 90 mm;
and 4, assembling the titanium plate (1) sprayed with the hydroxyapatite (2) and the locking plate (3), and performing ultrasonic cleaning, drying and sterilization treatment.
CN202111388903.8A 2021-11-22 2021-11-22 Ultrathin anterior cervical biological titanium plate and preparation method thereof Pending CN114052878A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115212348A (en) * 2022-06-20 2022-10-21 四川大学 PEEK-based composite implant and preparation method and application thereof

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CN205515050U (en) * 2016-03-04 2016-08-31 常州华森医疗器械有限公司 Zero notch interbody fusion cage on porous titanium alloy people throat way
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115212348A (en) * 2022-06-20 2022-10-21 四川大学 PEEK-based composite implant and preparation method and application thereof

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Application publication date: 20220218