CN114042005A

CN114042005A - Suspension composition containing lamellar liquid crystal and preparation process thereof

Info

Publication number: CN114042005A
Application number: CN202111324185.8A
Authority: CN
Inventors: 陈国静; 孙吉龙; 李泽勇; 刘康; 周月华
Original assignee: Guangzhou Tinci Materials Technology Co Ltd
Current assignee: Guangzhou Tinci Materials Technology Co Ltd
Priority date: 2021-11-10
Filing date: 2021-11-10
Publication date: 2022-02-15
Anticipated expiration: 2041-11-10
Also published as: CN114042005B

Abstract

The invention belongs to the field of new materials, and particularly relates to a preparation process of a lamellar liquid crystal-containing suspension composition, which comprises the following steps: step 1: sequentially adding an anionic surfactant, alcohols, a nonionic surfactant and a proper amount of deionized water into a reactor, and heating and stirring until the system is clear; step 2: heating the mixture obtained in the step 1 to a first temperature, adding a crystallization aid, and stirring for a period of time while keeping the temperature; and step 3: adding a cationic polymer pre-dispersed with water, stirring for 3-5min, cooling to a second temperature, stirring at a low speed of no more than 400rpm, and keeping the temperature for a period of time; by adopting the preparation process, the composition with a lamellar liquid crystal network structure and a large number of Maltese cross patterns can be obtained, and good suspension capability can be provided for particles in a system. In addition, the invention also provides a suspension composition containing lamellar liquid crystal obtained based on the process.

Description

Suspension composition containing lamellar liquid crystal and preparation process thereof

Technical Field

The invention relates to the field of new materials, in particular to a suspension composition containing lamellar liquid crystal and a preparation process thereof.

Background

The shampoo is a complex composition, and contains oil-soluble and water-soluble substances and various 'particle' components, such as an anti-dandruff agent ZPT, silicone oil particles and the like. Due to the density difference, such particles tend to float or settle in the system, making the composition unstable. To increase stability in the system, one or more suspension stabilizers must be added.

Two suspension systems, carbomer and pearlescent flakes, are widely used, but both systems have certain limitations. The suspension performance of the carbomer system is high, but the system compatibility is low, and foam is influenced. The compatibility of the pearlescent system is high, but the appearance of the product can be directly influenced, the dry and wet hair effects of the product can be changed, and the temperature which can be borne by the pearlescent system product is lower.

The invention patent CN 111135109.A is a composition containing a liquid crystal solid structure, and discloses a method for suspending particles in a system by using the liquid crystal solid structure. However, the liquid crystal structure is a radial "octopus" or linear liquid crystal structure, and is not a common lamellar liquid crystal structure. Even so, no specific preparation method is disclosed in its entirety.

The invention patent CN1181006A discloses a stress stable lathering skin cleansing liquid composition comprising, in parts by weight of the liquid composition, (a) about 0.5 to about 10 parts by weight of a crystalline hydroxyl containing stabilizer such as trihydroxystearin; (b) about 1-30 parts of a lipid skin moisturizing agent; (c) about 5-30 parts of a surfactant, the combination of which has a CMC (critical micelle concentration) equilibrium surface tension value of 15-50; and (d) water; wherein the stress stable lathering skin cleansing liquid composition has a Lipid Deposition Value (LDV) of from about 5 to 100, and wherein the composition is stable for at least two weeks at 100 ° F.

Reference is made to page 17 of the specification, and the process steps are as follows: the crystallization aid is added firstly, and then various surface activities are added.

It was verified that this process is not feasible if a maltese cross pattern of liquid crystal material is to be prepared.

CN101517060A discloses an aqueous structured surfactant composition comprising an anionic surfactant selected from isethionate, taurate, sarcosinate and mixtures thereof; and electrolytes, and which are useful in personal care applications.

Reference is made to page 40 of the specification, and the preparation method is carried out by a one-pot method, and the specific adding sequence and the like are not limited.

The technical problem to be solved by the invention is as follows: how to prepare a composition with a lamellar liquid crystal network structure and a large amount of Maltese cross patterns to provide good suspension capacity for particles in a system.

Disclosure of Invention

One of the objects of the present invention is to provide a process for preparing a lamellar liquid crystal-containing suspension composition. By adopting the preparation process, the composition with a lamellar liquid crystal network structure and a large number of Maltese cross patterns can be obtained, and good suspension capability can be provided for particles in a system.

In addition, the invention also provides a suspension composition containing lamellar liquid crystal obtained based on the process.

In order to achieve the above object, the present invention provides a process for preparing a suspension composition containing lamellar liquid crystals, comprising the steps of:

step 1: sequentially adding an anionic surfactant, alcohols, a nonionic surfactant and a proper amount of deionized water into a reactor, and heating and stirring until the system is clear;

the anionic surfactant is one or more of fatty acyl methyl taurate, fatty acyl methyl taurine taurate, sodium lauroyl methyl isethionate, AES and amino acid anionic surfactant; the alcohol is at least one of polyalcohol and higher fatty alcohol;

among them, more preferably, the polyhydric alcohol is at least one of propylene glycol, 1, 3-butylene glycol, dipropylene glycol, and glycerin; the higher fatty alcohol is at least one of dodecanol, tetradecanol, hexadecanol, octadecanol and eicosanol. The alcohol can interact with the surfactant, so that the interfacial energy between the crystallization assistant and the solution is reduced, the formation of crystallization nuclei is promoted in the cooling process, and the generation of liquid crystal forms is promoted.

In the mixture obtained in step 1, the anionic surfactant is 18-28% of the total weight of the mixture;

the key of the step is as follows: controlling the anion active concentration in the mixture to be 18-28%, wherein the concentration is lower than the range, no liquid crystal is generated in the subsequent process, and the concentration is too thick when the concentration is higher than the range, so that the subsequent process cost is high;

step 2: heating the mixture obtained in the step 1 to a first temperature, adding a crystallization aid, and stirring for a period of time while keeping the temperature; the first temperature is 3-8 ℃ higher than the melting point of the crystallization promoter;

the crystallization aid is at least one of trihydroxystearin, tristearin, 12-hydroxystearic acid, hydroxystearin and hydrogenated lecithin;

trihydroxystearin is preferred. The crystallization aid is a main component for forming a liquid crystal form, and participates in the formation of the entire liquid crystal form in the composition. The crystallization aid is solid oil with a higher melting point and is insoluble in water. After the material is melted at high temperature, the material can be slowly separated out along with the reduction of the temperature and gradually forms a solid state. The formation of liquid crystal firstly needs to ensure that the crystallization promoter is fully solubilized under high temperature conditions, and slowly precipitates along with the reduction of temperature after forming a proper crystal dispersion, but because intermolecular van der waals force exists between the crystallization promoter and the surfactant in the system, the molecules of the crystallization promoter and the surfactant interact to form a solid substance attached to the micelle of the surfactant, the solid substance is between a solid state and a liquid state, namely the liquid crystal state, and a remarkable Maltese cross pattern can be seen by using a polarization microscope. If the previous solubilization is insufficient, trihydroxystearin can be changed into a large number of tiny crystals to be gathered in the system.

And step 3: adding a cationic polymer pre-dispersed with water, stirring for 3-5min, cooling to a second temperature, stirring at a low speed of no more than 400rpm, and keeping the temperature for a period of time; the second temperature is 15-25 ℃ lower than the melting point of the crystallization promoter;

in this step, it is noted that: 1. controlling the concentration of the anion activity in the mixture at the moment to be 18-28%; 2. too fast stirring at the second temperature may damage the liquid crystal structure; 3. aiming at different crystallization aids, the temperature can be controlled to be 50-70 ℃, and the specific numerical value is about 15-25 ℃ lower than the melting point of the crystallization aids;

in the mixture obtained in the step 3, the anionic surfactant accounts for 18-28% of the total weight of the mixture;

the dosage of the anionic surfactant, the alcohol, the nonionic surfactant, the crystallization assistant and the cationic polymer respectively corresponds to 6-20%, 0.1-3%, 0.5-5%, 0.1-1% and 0.1-4% of the total weight of the suspension composition; preferably: 6-8%, 0.3-2.7%, 0.5-3%, 0.1-1%, 0.3-2%;

preferably, AES may be selected as: at least one of sodium lauryl polyoxyethylene ether sulfate, sodium myristyl polyoxyethylene ether sulfate and sodium palmitol polyoxyethylene ether sulfate;

the sodium fatty acyl methyl hydroxyethyl sulfonate is at least one of sodium lauroyl methyl hydroxyethyl sulfonate, sodium cocoyl methyl hydroxyethyl sulfonate and sodium myristoyl methyl hydroxyethyl sulfonate;

the using amount of the anionic surfactant is preferably 6-10%; more preferably 6-8%;

in the preparation process of the lamellar liquid crystal-containing suspension composition, the fatty acyl methyl taurate is at least one of sodium methyl cocoyl taurate, sodium methyl lauroyl taurate and sodium methyl myristoyl taurate; the fatty acyl methyl taurine salt is at least one of sodium cocoyl methyl taurine, sodium lauroyl methyl taurine and sodium myristoyl methyl taurine.

More preferably, the sodium cocoyl methyl taurate surfactant is milder, has moderate accumulation parameters and moderate emulsifying capacity, interacts with other auxiliary surfactants to form a proper micelle structure, can better solubilize and disperse the crystallization aid under a high-temperature condition, generates a synergistic effect and promotes the formation of a liquid crystal form.

In the above process for preparing a lamellar liquid crystal-containing suspension composition, the nonionic surfactant is at least one of alkyl glucoside, fatty acyl monoethanolamine, and fatty acid glyceride.

The alkyl glucoside is one of decyl glucoside, lauryl glucoside, myristyl glucoside, and stearic glucoside. The fatty acyl monoethanolamine is one of cocamide MEA and lauramide MEA. The fatty glyceride is one of coconut oil glyceride, lauric glyceride, glyceryl myristate and glyceryl stearate

Fatty acyl monoethanolamine is preferred. The nonionic surfactant can assist in reducing the melting point of the crystallization aid, reduce the difficulty of process operation and contribute to the solubilization of the crystallization aid under high-temperature conditions. The crystallization aid is uniformly dispersed and is compounded and synergized with the taurine surfactant, thereby being beneficial to the precipitation of liquid crystal form.

In the above process for preparing a lamellar liquid crystal-containing suspension composition, the cationic polymer is a cationic polymer of the polyquaternium type or a cationic guar gum.

The polyquaternium is at least one of polyquaternium-10, polyquaternium-4, polyquaternium-47 and polyquaternium-22, preferably polyquaternium-10.

The cationic guar gum is one of guar gum hydroxypropyl trimethyl ammonium chloride and hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride, and preferably guar gum hydroxypropyl trimethyl ammonium chloride.

The cationic polymer primarily provides conditioning. If it has a high electric charge, it is more advantageous to drive the liquid crystal structure, but excessively strong molecular forces may cause compatibility of the formulation and problems in stability, such as flocculation.

In the above process for preparing a suspension composition containing lamellar liquid crystals, the process further comprises the step 4:

cooling to below 45 deg.C, adding amphoteric surfactant or other surplus materials, adjusting pH, and discharging; the pH is preferably 5.5-6.5;

the amphoteric surfactant is 2-8% of the total weight of the suspension composition.

In the above process for preparing a lamellar liquid crystal-containing suspension composition, the amphoteric surfactant is at least one of sodium fatty acyl amphoacetate, sodium fatty acyl amphodiacetate, fatty acyl propyl betaine, and fatty amide hydroxypropyl sulfobetaine. Cocamidopropyl betaine is preferred.

The amphoteric surfactant can form a more compact micelle structure with an anionic surfactant in a system, plays a role in thickening and stabilizing bubbles, and further reduces the irritation of the system.

In the above process for preparing a suspension composition containing a lamellar liquid crystal, the balance of the suspension composition is water; the residual materials are one or more of preservative, pH regulator and essence.

In the preparation process of the lamellar liquid crystal-containing suspension composition, the first temperature is 90-95 ℃, and the second temperature is 65-75 ℃;

in the step 1, the additive of deionized water is preferably used for adjusting the concentration of the anionic surfactant in the mixture in the step 1 to 18-28%;

the temperature in the step 1 is 70-75 ℃;

the stirring time in the step 2 is 10-30 min.

In the above process for preparing a lamellar liquid crystal-containing suspension composition, step 3 is specifically:

adding the cationic polymer pre-dispersed with water, stirring at the speed of 300-450rpm for 3-5min, cooling to a second temperature, stirring at a low speed of no more than 400rpm, and keeping the temperature for 20-40 min.

Additionally stated, the following are: deionized water is added most of the way to the end of the process of the invention;

in step 1, the concentration of the anionic surfactant is adjusted to a rated concentration by adding deionized water;

in step 3, deionized water is mainly used for dispersing the cationic polymer, and 1-5 parts of deionized water is generally added;

the balance of deionized water is added after step 3, preferably after the temperature is reduced in step 4.

Finally, the invention also provides a suspension composition prepared by the process as described above, which exhibits a Maltese cross pattern when the lamellar phase is observed under a polarizing microscope.

The invention has the following beneficial effects:

the composition is added into a hair cosmetic matrix, the liquid crystal form of the composition can stably exist in a system, and a large amount of lamellar liquid crystal network structures (Maltese cross patterns), namely the classical liquid crystal form, are utilized to provide good suspension capacity for particles in the system.

Drawings

FIGS. 1-2 are liquid crystal microscope images of examples 1-8 of the present invention and comparative examples 1-2;

FIG. 3 is a graph showing the effect of suspension in examples 2 and 4 and comparative examples 1 to 2.

Detailed Description

The technical solutions of the present invention are described in further detail below, but the present invention is not limited thereto.

Examples 1 to 5

a. Heating to 70 ℃, sequentially adding the components in the A, B, C phase and a small amount of water, and stirring until the solution is clear and transparent; the anion active concentration in the mixture is controlled to be 23%, the subsequent liquid crystal does not generate when the concentration is lower than the range, the subsequent liquid crystal is too thick when the concentration is higher than the range, and the subsequent process cost is high;

b. heating to 90-95 deg.C, adding phase D, stirring for 20 min;

c. adding the E phase pre-dispersed with water, and uniformly stirring at the speed of 400rpm for 4 min; cooling to 65 deg.C, stirring at low speed (preferably 350 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture at 20%;

d. cooling to below 45 deg.C, adding F phase or other surplus materials, adjusting pH, and discharging.

The specific formulation can be found in table 1 below.

Table 1 formula table

What needs to be additionally stated is that: the presence of PEG-120 methyl glucose dioleate in phase E provides primarily a thickening effect and is not a major core component of the present invention;

C12-C14 alkyl glucoside in phase F also provides thickening and suspension stabilization; polydimethylsiloxane is one of silicone oils, which has good stability in a suspended state and does not serve as a main core component of the present invention.

In fig. 3, it is shown that silicone oils exhibit significant delamination in unstable systems.

Example 6

a. Heating to 70 ℃, sequentially adding the components in the A, B, C phase and a small amount of water, and stirring until the solution is clear and transparent; controlling the concentration of the anion activity in the mixture at 27 percent;

b. heating to 90-95 deg.C, adding phase D, stirring for 20 min;

c. adding the E phase pre-dispersed with water, and uniformly stirring for 4min at the speed of 450 rpm; cooling to 75 deg.C, stirring at low speed (preferably 350 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture at 23%;

The specific formulation can be found in table 2 below.

Example 7

a. Heating to 70 ℃, sequentially adding the components in the A, B, C phase and a small amount of water, and stirring until the solution is clear and transparent; controlling the concentration of the anion activity in the mixture at the moment to be 24 percent;

b. heating to 90-95 deg.C, adding phase D, stirring for 20 min;

c. adding the E phase pre-dispersed with water, and uniformly stirring at the speed of 400rpm for 4 min; cooling to 70 deg.C, stirring at low speed (preferably 350 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture at 21%;

The specific formulation can be found in table 2 below.

Example 8

a. Heating to 70 ℃, sequentially adding the components in the A, B, C phase and a small amount of water, and stirring until the solution is clear and transparent; controlling the anion active concentration in the mixture to be 21%, wherein the concentration is lower than the range, no liquid crystal is generated in the subsequent process, and the concentration is too thick when the concentration is higher than the range, so that the subsequent process cost is high;

b. heating to 90-95 deg.C, adding phase D, stirring for 20 min;

c. adding the E phase pre-dispersed with water, and uniformly stirring for 4min at the speed of 450 rpm; cooling to 65 deg.C, stirring at low speed (preferably 350 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture at 18%;

The specific formulation can be found in table 2 below.

Table 2 formula table

The associated liquid crystal effect micrographs of examples 1-8 can be found in FIGS. 1-2.

Examples 9 to 11

Examples 9-11 reference the preparative flow of example 1, which is formulated as follows in table 3:

table 3 formula table

What needs to be additionally stated is that: the experimental range of the amount of the anionic active compounds of the examples 1 to 11 of the present invention is only 6 to 8%; however, in the actual laboratory experiment process, the related cases of 10%, 15% and 20% of total dosage of the anionic active compound are verified, and the corresponding liquid crystal phase can be generated; the reason why only 6-8% of the amount is used in this example is that the amount of the anionic surfactant shown in this example is the solid content weight, the amount of the anionic surfactant indicated in the package of the commercially available product is the non-solid content amount, and the amount of 6-8% of the amount of the anionic surfactant in this example corresponds to 15-25% of the amount of the anionic surfactant in the commercially available product; the choice of the amounts of 10%, 15%, 20% of anionic activity is not of great commercial significance in the market products, mainly at too high a cost, and if used at such amounts, the end product is far beyond 30% solids and is not commercially valuable.

In examples 1 to 11, fatty acyl methyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, and sodium cocoyl methyl taurate in fatty acyl methyl taurate were verified, and at the same time, we also verified other specific surface activities of taurate, sodium fatty alcohol polyoxyethylene ether sulfate AES (verified by selecting sodium lauryl alcohol polyoxyethylene ether sulfate and sodium palmityl alcohol polyoxyethylene ether sulfate), and sodium fatty acyl methyl isethionate (verified by selecting sodium lauroyl methyl isethionate), and it was found through verification that, as long as the dosage and process control according to the present invention are used, a phase with a maltese cross pattern can be successfully prepared with high liquid crystal repetition rate and stability.

The alcohols are selected from dodecanol, tetradecanol, hexadecanol, octadecanol, eicosanol, propanediol, 1, 3-butanediol, dipropylene glycol, glycerol, all of which are possible, and the selection in the range of 0.5-5% does not affect the formation of the liquid crystal phase of the Maltese cross pattern.

The invention can select and add other additives with stability, thickening property, color and smell and the like according to the needs.

Comparative example 1

The formulation is exactly the same as in example 1;

the process comprises the following steps:

a. heating to 70 ℃, sequentially adding the components in the A, B, C phase and a small amount of water, and stirring until the solution is clear and transparent; controlling the concentration of the anion activity in the mixture at 23 percent;

b. adding the E phase pre-dispersed with water, and uniformly stirring at the speed of 400rpm for 4 min; cooling to 65 deg.C, stirring at low speed (preferably 250 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture to 20%

c. Heating to 93 ℃, adding the phase D, and stirring for 20min under the condition of heat preservation;

Referring to fig. 2, there is no liquid crystal structure (a large number of fine light-emitting crystals are present under polarized light).

Comparative example 2

The formulation is exactly the same as in example 1;

the process comprises the following steps:

a. heating to 70 ℃, sequentially adding the components in the A, B, C phase and a large amount of water, and stirring until the solution is clear and transparent; controlling the concentration of the anion activity in the mixture at the moment to be 15%;

b. heating to 93 ℃, adding the phase D, and stirring for 20min under the condition of heat preservation;

c. adding the E phase pre-dispersed with water, and uniformly stirring at the speed of 400rpm for 4 min; cooling to 65 deg.C, stirring at low speed (preferably 250 rpm), and maintaining for 30min while controlling the anionic activity concentration in the mixture at 13%;

Referring to fig. 2, the anionic activity concentration of step 1 was adjusted to be below 18% observation: no liquid crystal structure (showing a large number of fine light-emitting crystals under polarized light).

Application example 1

The application formulations of examples 1-8 and comparative examples 1-3 were tested in suspension and the results are shown in Table 3.

TABLE 3 suspension Property test results

FIG. 3 is a photograph of a suspension test of a portion of a sample.

As can be seen from Table 3 and FIG. 3, examples 1 to 8 of the present invention all had better liquid crystal stability and storage stability.

To achieve this effect, attention is paid to control the following factors:

besides controlling proper formula proportion, the method is crucial to control of initial apparent concentration, material adding sequence and temperature rising amplitude, and is related to whether a stable liquid crystal system can be formed.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims

1. A process for preparing a lamellar liquid crystal-containing suspension composition, comprising the steps of:

the anionic surfactant is one or more of fatty acyl methyl taurate, fatty acyl methyl taurine taurate, fatty acyl methyl hydroxyethyl sodium sulfonate, AES and amino acid anionic surfactant; the alcohol is at least one of polyalcohol and higher fatty alcohol;

the amounts of anionic surfactant, alcohol, nonionic surfactant, crystallization aid, and cationic polymer are 6-20%, 0.1-3%, 0.5-5%, 0.1-1%, and 0.1-4% by weight of the total suspension composition, respectively.

2. The process for preparing a lamellar liquid crystal-containing suspension composition according to claim 1, characterized in that the fatty acyl methyl taurate is at least one of sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate; the fatty acyl methyl taurine salt is at least one of sodium cocoyl methyl taurine, sodium lauroyl methyl taurine, and sodium myristoyl methyl taurine; AES is at least one of sodium lauryl polyoxyethylene ether sulfate, sodium myristyl polyoxyethylene ether sulfate and sodium palmitol polyoxyethylene ether sulfate; the sodium fatty acyl methyl hydroxyethyl sulfonate is at least one of sodium lauroyl methyl hydroxyethyl sulfonate, sodium cocoyl methyl hydroxyethyl sulfonate and sodium myristoyl methyl hydroxyethyl sulfonate.

3. The process for preparing a lamellar liquid crystal-containing suspension composition according to claim 1, characterized in that the non-ionic surfactant is at least one of alkyl glycoside, fatty acyl monoethanolamine, fatty glyceride, the cationic polymer is a cationic polymer of the polyquaternium type or cationic guar gum, the alcohol is at least one of polyol and higher fatty alcohol, wherein the polyol is at least one of propylene glycol, 1, 3-butylene glycol, dipropylene glycol, glycerol; the higher fatty alcohol is at least one of dodecanol, tetradecanol, hexadecanol, octadecanol and eicosanol.

4. The process for preparing a suspension composition containing lamellar liquid crystals according to claim 1, characterized in that the anionic surfactant, the alcohols, the non-ionic surfactant, the co-crystallizing agent, the cationic polymer are used in amounts corresponding to 6-8%, 0.3-2.7%, 0.5-3%, 0.1-1%, 0.3-2% respectively of the total weight of the suspension composition.

5. The process for preparing a lamellar liquid crystal-containing suspension composition according to claim 1, characterized in that it further comprises step 4:

cooling to below 45 deg.C, adding amphoteric surfactant or other surplus materials, adjusting pH, and discharging;

6. The process for preparing a lamellar liquid crystal-containing suspension composition according to claim 5, characterized in that the amphoteric surfactant is at least one of sodium fatty acyl amphoacetate, sodium fatty acyl amphodiacetate, fatty acyl propyl betaine, fatty amide hydroxypropyl sulphobetaine.

7. The process for preparing a suspension composition containing lamellar liquid crystals according to claim 5, characterized in that the balance of the suspension composition is water; the residual materials are one or more of preservative, pH regulator and essence.

8. The process for preparing a suspension composition containing lamellar liquid crystals according to claim 1, characterized in that the first temperature is between 90 and 95 ℃ and the second temperature is between 65 and 75 ℃;

the temperature in the step 1 is 70-75 ℃;

the stirring time in the step 2 is 10-30 min.

9. The process for preparing a suspension composition containing lamellar liquid crystals according to claim 1, characterized in that said step 3 is in particular:

10. A suspension composition prepared by the process of any of claims 1-9, wherein the lamellar phase exhibits a maltese cross pattern when viewed under a polarizing microscope.