CN113984764A - Detection device and automatic observation system suitable for disintegration tester - Google Patents
Detection device and automatic observation system suitable for disintegration tester Download PDFInfo
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- CN113984764A CN113984764A CN202111263169.2A CN202111263169A CN113984764A CN 113984764 A CN113984764 A CN 113984764A CN 202111263169 A CN202111263169 A CN 202111263169A CN 113984764 A CN113984764 A CN 113984764A
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- 238000001514 detection method Methods 0.000 title claims abstract description 36
- 238000012545 processing Methods 0.000 claims abstract description 42
- 239000003814 drug Substances 0.000 claims abstract description 41
- 238000012544 monitoring process Methods 0.000 claims abstract description 16
- 238000009507 drug disintegration testing Methods 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims description 15
- 238000003384 imaging method Methods 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000001454 recorded image Methods 0.000 claims description 3
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- 238000007689 inspection Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 36
- 230000008569 process Effects 0.000 abstract description 32
- 230000008859 change Effects 0.000 abstract description 10
- 238000002474 experimental method Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
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- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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Abstract
The invention provides a detection device, which comprises an observation element and a processing element, wherein the observation element is used for acquiring image and shape data of an object to be observed and transmitting the image and shape data to the processing element. And the automatic observation system suitable for the disintegration tester comprises the disintegration tester and the detection device, and is used for detecting the change and time in the disintegration process of the medicine. The system also comprises an image processing system, a monitoring processing system and a time limit comparison system, and can record and compare the process change in the drug disintegration process. The process of medicine disintegration is observed and recorded in the automation, reduces the manpower and pays out, can accurately acquire disintegration data and save in the computer, makes things convenient for the inquiry and the call in later stage.
Description
Technical Field
The invention relates to the field of medicine research instruments, in particular to a detection device and an automatic observation system suitable for a disintegration tester.
Background
At present, the disintegration time limit detection of food and medicine oral solid preparations at home and abroad is a very important index, but the whole disintegration process is observed manually by naked eyes in the current disintegration time limit detection process, the operation of different personnel has difference, the control accuracy of manual naked eye observation is not high, the whole process is memorized by human memory, the whole disintegration process cannot be recorded and displayed accurately and effectively, the condition that the judgment standards are inconsistent can occur, and the data of the disintegration process cannot be displayed and controlled visually and truly after the experiment is finished. The artificial visual observation has artificial subjective judgment, the condition that the judgment of the disintegration time limit is inaccurate exists, electronic data or printing data does not exist, and meanwhile, the effective supervision of the index in the production process is not facilitated.
In view of this, the present application is specifically made.
Disclosure of Invention
The invention aims to provide a detection device and an automatic observation system suitable for a disintegration tester. The system provides a detection device and an automatic observation system suitable for a disintegration tester, can automatically observe and record the disintegration process of the medicine, can accurately acquire the disintegration data and store the data in a computer, and facilitates later-stage query and calling.
The embodiment of the invention is realized by the following steps:
a detection device, comprising:
the observation element is used for acquiring image and shape data of an object to be observed and transmitting the image and shape data to the processing element.
Further, the viewing elements further include a light source assembly for providing an illumination environment when the light source assembly is used to acquire the image and shape data for the viewing elements.
In a second aspect, the invention provides an automatic observation system suitable for a disintegration tester, which comprises the disintegration tester and the detection device, wherein the detection device is used for detecting the change and time in the disintegration process of a medicament; the computer is in communication connection with the processing element; the detection device collects and records images and shape data of the medicine in real time and sends the collected and recorded images and shape data to the computer.
Further, the processing unit further comprises a timing module for setting a time interval in advance, and the detection device captures and records the image and shape data of the drug once every time the disintegration time reaches the end point time of the time interval.
Further, the computer comprises a database unit, and the database unit is used for storing preset standard images of the disintegrating drugs and data information transmitted by the detection equipment.
Furthermore, the computer also comprises an image processing system, a monitoring processing system and a time limit comparison system; the image processing system is used for imaging the electric signal transmitted by the detection device and outputting a real-time image of drug disintegration in the system; the monitoring processing system can judge and record the real-time image and store the disintegration time into the database unit.
Furthermore, the monitoring processing system comprises a first judging module, which is used for comparing and judging the received nth real-time image with the first received real-time image in the monitoring activity, outputting a comparison result after each conversion and storing the comparison result in the database unit, wherein n is more than or equal to 2.
Furthermore, the time limit comparison system comprises a second judgment module, can preset images and time of drug disintegration, and is used for comparing and recording the difference between the disintegration degree of the real-time images and the standard images at the same time point or the difference between the disintegration time at the same disintegration degree.
Furthermore, the disintegration tester also comprises an environment box which is used for providing a temperature environment for the disintegration of the medicine; and the medicine tube is arranged in the environment box and used for containing the medicine and providing a space for the medicine to disintegrate.
Further, the computer further comprises a printing device for printing and outputting disintegration data information of the medicine.
The embodiment of the invention has the beneficial effects that:
this system provides a detection device and is applicable to the automatic observation system of appearance that disintegrates, can be automatic observe and record the process that the medicine disintegrates, prevents the injury that the experimenter caused at observation in-process asthenopia, also avoids the experimenter to go from experience angle to confirm observation time, leads to the experiment failure or the unsafe condition of record appears. Can accurately acquire disintegration data and store the disintegration data in a computer, and is convenient for later-stage query and calling.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic view of a detection apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an automatic observation system suitable for a disintegration tester according to another embodiment of the present invention;
fig. 3 is a functional structure diagram of an automatic observation system according to an embodiment of the present invention.
Icon:
1-detection equipment, 1.1-processing element, 1.2-light source component, 1.3-observation element, 2-disintegration tester, 2.1-environmental box, 2.2-test tube, 3-computer, 3.1-database, 3.2-image processing system, 3.3-monitoring processing system, 3.4-time limit comparison system, 4-printer and 5-switch.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
Furthermore, the terms "parallel," "perpendicular," and the like do not require that the components be absolutely parallel or perpendicular, but may be slightly inclined. For example, "parallel" merely means that the directions are more parallel relative to "perpendicular," and does not mean that the structures are necessarily perfectly parallel, but may be slightly tilted.
Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.
The terms "substantially", "essentially", and the like are intended to indicate that the relative terms are not required to be absolutely exact, but may have some deviation. For example: "substantially equal" does not mean absolute equality, but it is difficult to achieve absolute equality in actual production and operation, and some deviation generally exists. Thus, in addition to absolute equality, "substantially equal" also includes the above-described case where there is some deviation. In this case, unless otherwise specified, terms such as "substantially", and the like are used in a similar manner to those described above.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
Referring to fig. 1, the detecting apparatus 1 provided in this embodiment includes an observing element 1.3 and a processing element 1.1, where the observing element 1.3 is configured to obtain an image and shape data of an object to be observed, and transmit the image and shape data to the processing element. In particular, the viewing element 1.3 can be any visual device with viewing and retention functions, in this embodiment an industrial camera is used for image capturing. The processing element 1.1 is arranged in the industrial camera and can be divided into an optical system, a photoelectric conversion system and a circuit system, wherein the optical system mainly refers to a device for capturing optical signals such as a lens; the photoelectric conversion system mainly refers to photoelectric devices such as a camera tube or a fixed camera device and the like which can convert optical signals into electric signals; and a circuit system, which is mainly used for processing the circuit and connecting and transmitting signals to the computer.
Because the change that the medicine disintegrates in the actual disintegration process is for leading to liquid discolour or the phenomenon that appears being difficult to observe, observe the component and still include light source subassembly 1.2, light source subassembly 1.2 refers to natural light or artifical auxiliary lighting light for when industry camera acquireed image and shape data, provide the illumination environment, the better industry camera of being convenient for catches clearer and more accurate image data.
Example 2
The embodiment provides an automatic observation system suitable for a disintegration tester, please refer to fig. 2, an automatic observation system suitable for a disintegration tester. Comprises a disintegration tester 2 and a detection device 1 in the embodiment 1, which is used for detecting the change and time in the disintegration process of the medicine. A computer 3 in communication connection with the processing element 1.1; the detection device 1 collects and records images and shape data of the medicine in real time, and sends the collected and recorded images and shape data to the computer 3. Specifically, the image and shape data refers to a specific contour shape of the drug during the disintegration process. The medicine will dissolve in liquid, and the process of the medicine gradually dissolving from the complete solid state, the volume is reduced, the shape is disordered, and the automatic observation system observes the disintegration process change of the medicine through the detection device 1 and transmits the disintegration process change to the computer system 3 for analysis.
During the disintegration process, the drug is illuminated by natural light or artificial auxiliary lighting to produce reflected light, a portion of which passes through the imaging objective of the viewing element 1.3. After being imaged by the objective lens, the image falls on the image sensing surface of the photoelectric imaging device of the processing element 1.1, and the photoelectric device controlled by the driving circuit can quickly respond to the target image on the image sensing surface, namely, charge packets with response sizes are generated at each sampling point, namely pixel points according to the distribution of the light energy of the target image on the image sensing surface, so that the photoelectric conversion of the image is completed. And then the electric signal is transmitted to a computer so as to analyze the data provided by the observation element to obtain a disintegrating object image.
Since drug disintegration is a dynamically changing process, it requires real-time and multiple tests. In order to accomplish the above, the processing unit 1.1 further comprises a timing module. The timing module is used for setting a time interval in advance, and when the disintegration time reaches the endpoint time of the time interval, the industrial camera can shoot and retain the medicine. The specific time interval is not limited in this embodiment, and in the actual use process, experimenters can set the time interval according to different drug disintegration speeds. Thus, the morphological change of the drug disintegration process which is averaged for a plurality of times on a time axis can be known.
After receiving the data information provided by the detection device 1, the computer 3 needs to perform an analysis operation on the data information. In this embodiment, the computer 3 further comprises an image processing system 3.2, a monitoring processing system 3.3 and a time limit comparison system 3.4.
The image processing system 3.2 is used for imaging the electric signal transmitted by the detection device 1 and outputting a real-time image of the drug disintegration in the system. Specifically, the obtained image is decomposed into pixel point distributions in a preset coordinate axis, and different experiment requirements have different particle size divisions, which is not limited in this embodiment. The real-time image is embodied as a closed plane surrounded by the distribution of the edge pixel points of the image. The image processing system 3.2 then transmits the real-time image information to the monitoring processing system 3.3 for judgment and recording.
The monitoring processing system 3.3 can judge and record the real-time image and store the disintegration time into the database 3.1. The method comprises the following steps: the switch 5 is pressed, the detection device 1 can automatically perform when the disintegration tester 2 is started, when the object starts to be formally detected (disintegrated), the real-time image transmitted by the image processing system 3.2 is different from the standard image, the time for receiving the disintegration start (color or shape change) can be transmitted to the database 3.1 to start recording time, the end time is stored into the database 3.1 again at the first time after the disintegration object is completely disintegrated (the solution is discolored, turbid or no particles are consistent with the standard complete image), the time for starting and ending the disintegration can be completely recorded, the whole disintegration process (namely the dynamic change splitting diagram of the appearance of the drug in the disintegration process) is continuously transmitted and recorded in the process, and the disintegration process is displayed on a computer interface and stored in the database of the experimental operation at this time.
In order to achieve a good experimental effect, a first judgment module is further arranged in the monitoring processing system 3.3, and the first judgment module has a pixel point analysis function. The called standard image and the called real-time image can be subjected to coincidence analysis to obtain the difference condition of the non-coincident pixel points of each real-time image and the standard image, and the difference condition is taken as the horizontal axis to output a curve graph of the percentage difference between the time change and the standard image in the drug disintegration process. Can help experimenters find the disintegration smoothness and the problem of mutation points in the disintegration process. Specifically, the judgment standard is as follows: the real-time image acquired for the first time in the experiment is taken as a standard image, and the image captured at the endpoint of each time interval is taken as a real-time image. And comparing each real-time image with the first acquired standard image in the operation work to obtain the variation range of the comparison last time endpoint in each fixed time, and outputting the variation degree.
This example provides a contrast function in addition to the detection of the process of self-disintegration of a single drug. Specifically, the computer further comprises a time-limit comparison system 3.4, which can artificially give a standard disintegration time-limit instruction to the system before disintegration, namely a standard and complete image (solution discoloring, turbidity or no particulate matter and the like), compares the standard and complete image with the monitored real-time image, starts timing when disintegration is started or the image is detected to be inconsistent, and stops timing when the monitored image is consistent with the standard image, so that the total disintegration time can be obtained and data can be recorded.
Specifically, the time limit comparison system comprises a second judgment module, and the specific judgment mode is as follows: before the disintegration time limit is detected, a person inputs the standard time limit of the object to be detected at this time on the operation screen, and transmits the standard time limit to a time limit comparison system 3.4 through data transmission to give the standard time limit of the detection; inputting a disintegration judgment standard in an operation screen, wherein the percentage of a standard image (for example, 1.0 percent, if 0 is input, the tablet is judged to be qualified after being completely disintegrated) is transmitted to a monitoring processing system 3.3 and a time limit comparison system 3.4 through data transmission, and the disintegration time limit completion judgment standard is given; the detection device 1 starts to operate after the disintegration tester 2 is started, when the disintegration process of the tablet reaches the time interval end point, the detection device 1 transmits a signal to the computer 3, and the time limit comparison system 3.4 calls a time limit and an image preset in a database to be used as a standard image for comparison; when the tablet disintegration process reaches the time interval end point, the detection device 1 captures image information and transmits the image information to the image processing system 3.2, outputs imaging and sends the imaging information to the monitoring processing system 3.3, and outputs a current image. And comparing the real-time image result of each time with the shape, size and pixel point distribution of the standard image in the database 3.1, calculating, and transmitting the result data to a time limit comparison system. Repeating the above steps until the tablet is disintegrated (such as 1.0% of the standard image shape and size), stopping the operation of the disintegration tester 2, outputting disintegration data and standard time difference, and displaying finish prompt information on the operation screen to finish disintegration.
Optimally, the embodiment also provides a disintegration tester 2 for providing environment for drug disintegration. Comprises an environment box 2.1 for providing temperature environment for the disintegration of the medicine; and the medicine tube 2.2 is arranged in the environment box, and the medicine tube 2.2 is used for containing medicines and providing a space for the medicines to disintegrate. The real-time environment box 2.1 is filled with liquid with a certain temperature for simulating a human body or a temperature environment with specific requirements. The box is made of a heat-insulating material, so that the temperature in the box can be kept stable. The real-time medicine tube 2.2 can adopt beakers or test tubes and other transparent devices which are easy to place and observe according to different medicines in a specific using process. The embodiment adopts a test tube with artificial gastric juice in the interior to simulate the disintegration environment to observe the drug disintegration. And immersed in the liquid of the environmental chamber 2.1 to simulate the temperature of the human body.
In order to facilitate subsequent work and experiments, the computer 3 is further connected with a printing device 4, and the printing device 4 can be an external screen or a printer or other devices for externally outputting data. The embodiment is not limited, and experimenters can be reasonably and flexibly arranged by combining with actual production requirements when equipping the system.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. It should be noted that structures or components illustrated in the drawings are not necessarily drawn to scale, and descriptions of well-known components and processing techniques and procedures are omitted to avoid unnecessarily limiting the invention.
Claims (10)
1. A detection device, comprising:
the observation element is used for acquiring image and shape data of an object to be observed and transmitting the image and shape data to the processing element.
2. The inspection device of claim 1, wherein the viewing elements further comprise a light source assembly configured to provide an illuminated environment for the viewing elements when acquiring the image and shape data.
3. An automatic observation system suitable for a disintegration tester, comprising a disintegration tester and a detection device according to claim 1 or 2 for detecting changes and time during disintegration of a drug; the computer is in communication connection with the processing element; the detection device collects and records images and shape data of the medicine in real time and sends the collected and recorded images and shape data to the computer.
4. The system of claim 3, wherein the processing unit further comprises a timing module for setting a time interval in advance, and the detection device captures and records the image and shape data of the drug once each time the disintegration time reaches the end of the time interval.
5. The automatic observation system suitable for the disintegration tester of claim 4, wherein the computer comprises a database unit, and the database unit is used for storing preset standard images of the disintegration tester and data information transmitted by the detection device.
6. The automatic viewing system for a disintegration tester as claimed in claim 5, wherein said computer further comprises an image processing system, a monitoring processing system and a time-limit comparison system; the image processing system is used for imaging the electric signal transmitted by the detection device and outputting a real-time image of the drug disintegration in the system; the monitoring processing system can judge and record the real-time image and store the disintegration time into the database unit.
7. The automatic observation system suitable for the disintegration tester of claim 6, wherein the monitoring processing system comprises a first judgment module, which is used for comparing and judging the received nth real-time image with the first received real-time image in the current monitoring activity, outputting the comparison result after each conversion, and storing the comparison result in the database unit, wherein n is greater than or equal to 2.
8. The system of claim 7, wherein the time-limit comparison system comprises a second determination module for presetting the image and time of drug disintegration, and comparing and recording the difference between the disintegration degree of the real-time image and the standard image at the same time point, or the difference between the disintegration time at the same disintegration degree.
9. The automatic observation system suitable for the disintegration tester of claim 8, wherein the disintegration tester further comprises an environmental chamber for providing a temperature environment for the disintegration of the drug; and the medicine tube is arranged in the environment box and used for containing medicines and providing a space for the medicines to disintegrate.
10. The automated vision system for a disintegration tester of claim 9, wherein the computer further comprises a printing device for printing out disintegration data information for the drug.
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