CN113940341A - Paraquat composition containing cellulose derivative and application of paraquat composition in attenuation of mammals - Google Patents
Paraquat composition containing cellulose derivative and application of paraquat composition in attenuation of mammals Download PDFInfo
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- CN113940341A CN113940341A CN202010689738.9A CN202010689738A CN113940341A CN 113940341 A CN113940341 A CN 113940341A CN 202010689738 A CN202010689738 A CN 202010689738A CN 113940341 A CN113940341 A CN 113940341A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pest Control & Pesticides (AREA)
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Abstract
The present invention relates to a paraquat composition comprising a cellulose derivative and the use thereof for attenuating toxicity in mammals, said paraquat composition comprising paraquat and a cellulose derivative, the cellulose derivative being a water-soluble cellulose anionic derivative. The weight ratio of paraquat to cellulose derivative is 1: (0.05-1.00). The cellulose derivative is added to the paraquat composition, so that the active ingredient paraquat cannot be absorbed by intestines and stomach of mammals after the paraquat is mistakenly taken by the mammals under the condition that the paraquat raw material, the mother material and the preparation are dissolved in water, and the paraquat is prevented from entering blood of the mammals, so that the paraquat is nontoxic or slightly toxic to the mammals.
Description
Technical Field
The invention belongs to the field of pesticides, and particularly relates to a paraquat composition containing a cellulose derivative and application of the paraquat composition to attenuation of mammals.
Background
Paraquat is a quick non-selective quaternary ammonium salt herbicide, is widely applied to agricultural cultivation due to strong weeding effect and low price, makes great contribution to grain yield increase, production cost reduction and no-tillage technology development all over the world, and brings immeasurable economic benefits. However, paraquat, a highly toxic compound, also causes irreversible lung injury and fibrosis in mammals, especially humans, and deteriorates between days and 3 weeks after ingestion, where hundreds of thousands of people die each year from ingestion of paraquat.
Paraquat poisoning seriously threatens the life safety and the physical health of patients. The conventional treatment method of paraquat poisoning is emetic and gastric lavage, and the novel treatment method of paraquat poisoning mainly comprises lung transplantation, bone marrow mesenchymal stem cell transplantation, methylprednisolone combined technology and the like at present.
However, the above conventional treatment methods can only alleviate the disease to some extent, cannot completely control the progress of the disease and finally cure, and it is a post-cure, and damage to mammals and humans has been caused. In particular, advanced technologies such as lung transplantation and stem cell transplantation are not mature enough. For example, in lung transplantation therapy, fibrosis is reoccurred in some cases; the bone marrow mesenchymal stem cell transplantation is combined with methylprednisolone to treat paraquat poisoning, and serious complications such as lung infection, drug-induced liver and kidney damage and the like can be caused.
The measures adopted at present are mainly to hope to reduce the concentration of paraquat in blood as early as possible, and how to thoroughly remove residual paraquat in intestinal tracts and reduce subsequent continuous damage to lung tissues by advancing a treatment time window.
The existing rescue methods mainly take prevention and symptomatic treatment, generally carry out the rescue by direct detoxification, indirect detoxification or paraquat metabolism promotion, including extracorporeal treatment methods such as hemodialysis and the like, and can slow the state of an illness to a certain extent but cannot control the curative effect exactly because the existing rescue methods are less related to the treatment link after poisoning. In the existing therapeutic drugs, chemical chelating agents or macromolecular adsorbents are mostly used, but the drugs are difficult to be used for human bodies because of poor safety in vivo and possibly larger toxic and side effects. For the combination therapy of Chinese medicinal materials, the material base and detoxification mechanism are unknown, and the drug effect is interfered by the raw materials of crude drugs, the processing method, the strong hepatotoxicity of individual medicinal materials, the compatibility dosage, individual difference and other influencing factors, so that the prevention and treatment effect is uncertain. However, there is no effective method for preventing paraquat poisoning in advance, especially for preventing paraquat poisoning in case of taking the medicine by mistake. Therefore, it is important to explore the poisoning mechanism of paraquat and the antidote.
The invention finds out that a more effective toxicity prevention way for paraquat is to block the absorption of paraquat in the intestines and stomach of a human body and block paraquat from entering the blood of a mammal, so that the paraquat cannot immediately cause the poisoning of the mammal or can completely avoid the poisoning of the mammal even if entering the intestines and stomach of the mammal.
Disclosure of Invention
In order to solve the technical problems, the invention provides a paraquat composition for reducing toxicity to mammals, which comprises paraquat and a cellulose derivative, wherein the cellulose derivative is a water-soluble cellulose anion derivative.
The water-soluble cellulose anion derivative is used as a detoxifying agent of paraquat, and can prevent the paraquat from being poisoned by the mammal after being taken by mistake or reduce the physiological damage of the paraquat to the mammal after being added into the paraquat.
In the present invention, an attenuating agent is defined as being capable of reducing the toxicity of paraquat, i.e., in the case where the attenuating agent is included before paraquat is taken by a mammal, the mammal is not poisoned by the attenuating agent after the paraquat is taken by the mammal or physiological damage of paraquat to the mammal is reduced, and damage to the mammal is delayed. The toxicity reducing agent of paraquat of the present invention is different from the toxicity reducing agent commonly known in the art, and is used by mixing paraquat with the toxicity reducing agent before the paraquat is taken by mistake, that is, mixing the toxicity reducing agent with paraquat in the process of preparing a paraquat raw drug, a mother drug or a paraquat preparation, and the paraquat mixed with the toxicity reducing agent does not cause poisoning or reduce physiological damage of paraquat to mammals even if the paraquat is taken by mistake, thereby delaying damage to the mammals. The term "attenuation" in the context of the present invention means that the toxicity of the medicament such as paraquat raw drug, mother drug, preparation and the like is reduced, and the toxicity of paraquat to the mammal can be reduced even if the mammal takes the medicament by mistake by adding the attenuation agent, so that the poisoning of paraquat can not be caused or the toxicity of paraquat to the mammal can be reduced, and the window period of treatment after the poisoning of the mammal can be prolonged.
Cellulose derivatives are of a wide variety, but when the cellulose derivative is anionic, i.e. the group to which the cellulose is bonded is anionic, and the salt of the cellulose to which the anionic group is bonded is water-soluble, the cellulose derivative is a water-soluble cellulose anionic derivative.
Preferably, in the above paraquat composition, the weight ratio of paraquat to cellulose derivative is 1: (0.01-5.00); preferably, the weight ratio of paraquat to cellulose derivative is 1: (0.05-1.00).
Among them, the water-soluble cellulose anion derivative is also referred to as a cellulose derivative in this patent, and the attenuation effect of the cellulose derivative on paraquat is found in the attenuation test of mammals by using paraquat in the present invention, and it is verified that the cellulose derivative can reduce the toxicity of paraquat in mammals by subjecting a mixture of the water-soluble cellulose anion derivative and paraquat to a toxicity test, that is, subjecting a composition comprising paraquat and the cellulose derivative to a toxicity test of mammals.
The water-insoluble matter content of the water-soluble cellulose anionic derivative is not more than 1.0% by weight, preferably not more than 0.5% by weight, based on the weight of the cellulose anionic derivative.
Preferably, in the paraquat composition, the water-soluble cellulose anionic derivative is one or more of a sodium salt of cellulose sulfate ester, a potassium salt of cellulose sulfate ester, an ammonium salt of cellulose sulfate ester, a sodium salt of carboxymethyl cellulose, a potassium salt of carboxymethyl cellulose, and an ammonium salt of carboxymethyl cellulose.
The cellulose anion derivative can realize the attenuation effect on paraquat, namely, the composition formed by adding the cellulose anion derivative into paraquat can effectively reduce the toxicity of paraquat on mammals if the composition is taken by the mammals by mistake.
Preferably, in the above paraquat composition, the cellulose derivative can achieve attenuation of 1, 1-dimethyl-4, 4-bipyridyl dichloride (CAS number: 1910-42-5), can also achieve attenuation of 1, 1-dimethyl-4, 4-bipyridyl bisulphate monomethyl ester salt (CAS number: 2074-50-2), and can even achieve attenuation of soluble salts of 1, 1-dimethyl-4, 4-bipyridyl cation (CAS number: 4685-14-7) with anions other than chloride ions and sulfate ions.
Therefore, in the above-mentioned paraquat composition, the paraquat is 1, 1-dimethyl-4, 4-bipyridine dichloride, 1-dimethyl-4, 4-bipyridine monosulfate salt or other soluble salt of 1, 1-dimethyl-4, 4-bipyridine cation, and preferably, the paraquat is 1, 1-dimethyl-4, 4-bipyridine dichloride or 1, 1-dimethyl-4, 4-bipyridine monosulfate salt.
Preferably, in the above-mentioned paraquat composition, the sum of the weight of paraquat and the weight of the cellulose derivative in the paraquat composition accounts for 5 to 99% of the weight of the paraquat composition, or the sum of the weight of paraquat and the weight of the cellulose derivative in the paraquat composition accounts for 100-10000ppm of the weight of the paraquat composition.
That is, the paraquat composition can be paraquat raw drug, paraquat mother drug, or paraquat preparation, or even paraquat liquid medicine used for field application after the paraquat preparation is diluted. If the paraquat is high-purity paraquat and the purity of the paraquat is more than 90%, the paraquat raw material and the cellulose derivative can be directly and fully mixed, and the composition formed after the full mixing can be prepared into a paraquat mother medicine, or the raw material or the mother medicine can be prepared into a paraquat preparation, or the paraquat preparation can be diluted into a liquid medicine capable of weeding in the field by using water.
Therefore, in the above paraquat composition, preferably, the paraquat composition is paraquat raw drug, paraquat mother drug, paraquat preparation or paraquat liquid drug.
The cellulose derivative in the paraquat composition can achieve the attenuation effect on paraquat no matter the paraquat composition is a raw drug, a mother drug or a preparation, or is a liquid medicine diluted into a field drug, namely, as long as the weight ratio of paraquat to the cellulose derivative in the paraquat composition is within the range, the paraquat composition can prevent mammals from being poisoned immediately after being taken by mistake, and the toxicity of paraquat to the mammals is reduced.
Preferably, in the paraquat composition, the paraquat composition is formed by mixing paraquat raw drug and cellulose derivative. The composition can be used as a raw drug, although the purity of the paraquat raw drug is reduced due to the addition of the cellulose derivative, the composition is more suitable for preparing a paraquat preparation due to the addition of the cellulose derivative, and the paraquat composition which can be used as the raw drug is not worried about being taken by a mammal by mistake, namely poisoning caused by taking the paraquat by mistake in a raw drug stage can be avoided, and the poisoning cannot be caused immediately even if the mammal, such as a human or livestock, takes the composition formed by mixing the paraquat raw drug and the cellulose derivative by mistake.
Preferably, in the above-mentioned paraquat composition, the paraquat composition is a paraquat mother drug, that is, the cellulose derivative is added in the process of preparing the paraquat mother drug, or the cellulose derivative is added after preparing the paraquat mother drug, and the attenuation of paraquat is realized by adding the cellulose derivative, and the adding amount of the cellulose derivative is 0.05-1.00 times of the weight of paraquat according to the above-mentioned description. Thus not only the quality of the paraquat mother drug is not influenced, but also the attenuation effect of the cellulose derivative on paraquat can be realized. The weight content of paraquat in the paraquat mother medicine is 30-45%, and the weight of the cellulose derivative is 1.5-45%.
Preferably, in the above-mentioned paraquat composition, the paraquat composition is a paraquat preparation, and the cellulose derivative may be added during the preparation of the paraquat preparation, or the cellulose derivative may be added after the preparation of the paraquat preparation, and in any form, the stability of the paraquat preparation is not affected, and the attenuation of the paraquat preparation to mammals can be realized. Preferably, in the paraquat composition, the paraquat composition is a paraquat preparation, the dosage form of the paraquat preparation is one of a soluble solution, a water-soluble granule, a water-dispersible granule, a granule, an effervescent tablet, a water-soluble paste and a microcapsule suspension, and the dosage form of the paraquat preparation is preferably a soluble solution or a water-soluble granule. In the paraquat preparation, the weight content of paraquat is 5-30%, and the weight content of cellulose derivative is 0.25-30%, or paraquat is soluble agent, the content of paraquat in the soluble agent is 50-300g/L, and the content of cellulose derivative is 0.25-300 g/L.
Preferably, in the paraquat composition, the paraquat composition is a paraquat liquid medicine, namely a liquid medicine capable of being directly sprayed on weeds to weed, the liquid medicine can be obtained by diluting a preparation containing paraquat and a cellulose derivative, or the cellulose derivative can be added in the diluting process of the paraquat preparation not containing the cellulose derivative, and the adding amount of the liquid medicine is 0.05-1.00 times of the weight of active ingredients of paraquat in the used paraquat preparation, so that the weeding activity of paraquat can be improved, and the paraquat liquid medicine has an attenuation effect on mammals. Preferably, in the paraquat composition, the paraquat composition is a paraquat liquid medicine, and the concentration of paraquat in the paraquat liquid medicine is less than or equal to 5000 ppm. Preferably, the concentration of paraquat in the paraquat liquid medicine is 100ppm to 5000ppm, and the weight content of the cellulose derivative is 0.05 to 1.00 times of the weight content of paraquat, namely the concentration of the cellulose derivative in the paraquat liquid medicine is 5ppm to 5000 ppm.
The invention also provides the use of a cellulose derivative which is a water-soluble cellulose anionic derivative for the preparation of a composition for attenuating toxicity to mammals.
Preferably, in the above use, the water-soluble cellulose anionic derivative is one or more of a sodium salt of cellulose sulfate ester, a potassium salt of cellulose sulfate ester, an ammonium salt of cellulose sulfate ester, a sodium salt of carboxymethyl cellulose, a potassium salt of carboxymethyl cellulose, and an ammonium salt of carboxymethyl cellulose.
Preferably, in the above use, the weight of the cellulose derivative in the paraquat composition is 0.05 to 1.00 times the weight of paraquat.
Preferably, in the above application, paraquat is 1, 1-dimethyl-4, 4-bipyridine dichloride or 1, 1-dimethyl-4, 4-bipyridine bissulfuric acid monomethyl ester salt.
The invention also provides a method for preparing the paraquat composition for reducing toxicity to mammals, which is characterized in that the water-soluble cellulose anion derivative is added in the process of preparing paraquat raw medicines, mother medicines and preparations, or the water-soluble cellulose anion derivative is added after the paraquat raw medicines, the mother medicines and the preparations are prepared, or the water-soluble cellulose anion derivative is added in the process of diluting the paraquat preparation into liquid medicine, or the water-soluble cellulose anion derivative is added after the paraquat preparation is diluted into the liquid medicine, and the adding amount of the water-soluble cellulose anion derivative is 0.05-1.00 times of the weight of the paraquat.
Preferably, in the above method, the water-soluble cellulose anionic derivative is one or more of a sodium salt of cellulose sulfate, a potassium salt of cellulose sulfate, an ammonium salt of cellulose sulfate, a sodium salt of carboxymethyl cellulose, a potassium salt of carboxymethyl cellulose, and an ammonium salt of carboxymethyl cellulose.
The invention has the advantages of
1. The invention finds that the water-soluble cellulose derivative can reduce the toxicity of paraquat to mammals. According to the paraquat composition, the cellulose derivative is added, so that paraquat molecules can be wrapped by the cellulose derivative to form particles under the condition that paraquat raw medicines, mother medicines and preparations are dissolved in water, and therefore after paraquat is taken by a mammal by mistake, active ingredients of paraquat are difficult to release from the particles, cannot be absorbed by intestines and stomach of the mammal, and the paraquat is prevented from entering blood of the mammal, so that the paraquat is nontoxic or slightly toxic to the mammal.
3. The invention verifies the condition of the water-soluble cellulose derivative for reducing the toxicity of paraquat. In the process of developing the paraquat composition, the invention verifies that the paraquat composition containing the water-soluble cellulose derivative can not be toxic or slightly toxic to mammals, can not reduce the weeding effect of paraquat and can even improve the weeding effect of paraquat by fully testing the property requirement, variety range selection, content range, weeding effect and the like of the cellulose derivative.
Detailed Description
The ingredients used in the following examples, 42wt% of paraquat master batch (the percentage being calculated on the mass of 1, 1-dimethyl-4, 4' -bipyridine dichloride), cellulose sulfate sodium salt, cellulose sulfate potassium salt, carboxymethylcellulose sodium salt, carboxymethylcellulose potassium salt were analytical grade and were all commercially available.
Example 1: preparation of paraquat composition
The preparation method comprises the following steps: mixing paraquat and cellulose derivative according to a proportion, adding 1000ml of water, fully mixing and dissolving, carrying out decompression spin drying on water and drying to obtain the paraquat composition.
According to the preparation method 1, the compositions are prepared according to the proportion of the cellulose derivatives and the paraquat mother medicines shown in the following table 1, and the serial number of the prepared paraquat composition, the variety of the cellulose derivatives and the dosage of the paraquat mother liquor are shown in the following table 1.
TABLE 1 compositions of cellulose derivatives and paraquat
Preparing a composition XR01-XR04 according to the variety of the cellulose derivatives, the mass of the toxicity reducing agent and the mass of the paraquat mother liquor, wherein no other auxiliary agent is added in the preparation process, and drying the prepared composition XR01-XR04 to obtain a dry product. The dried product is dissolved into an aqueous solution with the paraquat mass content of 20 percent, and the aqueous solution has no demixing and no precipitation. The prepared aqueous solution is subjected to a cold and hot storage experiment, and no layering phenomenon or precipitation phenomenon is found at day 56, which shows that the stability of the paraquat preparation can be realized only by preparing the paraquat preparation from the water-soluble cellulose derivative.
For example, XR01, XR02, XR03 and XR04 were dissolved in water to form 200g/L of a paraquat aqueous solution, stability tests were performed on the paraquat aqueous solution under conditions of storage at 54 ℃, 7 ℃ and-25 ℃ for 56 days, and then the stability of the paraquat aqueous solution was observed to be a transparent liquid without delamination and precipitation.
Example 2 toxicity test of Paraquat composition to mammal
Paraquat compositions XR01-XR04 in Table 1 were diluted with sterile aqueous solution to a mass concentration of 0.5% paraquat as experimental samples for use. A control group is set, wherein the number of the control group is XR05, and the control group is prepared by diluting 42wt% of paraquat mother drug to 0.5% of paraquat mass concentration, and is used as a control sample for standby. A blank set is provided, blank set No. XR06, sterile water is used as the blank and sterile water is the blank sample.
The prepared samples were subjected to animal toxicity test, and each sample was tested in 5 mice, each mouse was injected with 600. mu.L of the solution, and injected into the stomach. The mice were then observed for the number of deaths and the number of survivors per day, and the number of survivors was counted, see table 2 below.
TABLE 2 Effect of Paraquat compositions on survival in mice
In the course of the statistics, the death-determining criteria for the mice were that there was no more respiratory activity, and that survival was counted as long as there was respiratory activity. The mice injected with the XR01-XR04 samples all survived for more than 6 days, and by day 6 the mice were less alive and gradually died. The control mice failed to survive to day 6, and were poisoned quickly and with high mortality without attenuation of the cellulose derivative.
EXAMPLE 3 herbicidal Effect of Paraquat compositions
The above-mentioned paraquat composition was diluted to a multiple as shown in the following table 3 to conduct an experiment, and the herbicidal effect of the paraquat composition to which the cellulose derivative was added was verified. First, a concentration gradient test is carried out by using a paraquat aqueous solution of XR05, a weeding test is carried out on a forest weed land under the condition that paraquat of a control paraquat composition XR05 is diluted to 1000ppm (1 mg/ml), 2000ppm (2 mg/ml) and 5000ppm (5 mg/ml) (the average height of weeds in the forest land is 20 cm), the application time is at noon in a sunny day, three parallel are arranged at each concentration, 1 square meter is arranged in each parallel, and the weed death rate is counted 15 days after application.
The weed mortality (also known as weed kill or weed control) was calculated as:
the control composition XR05 showed weeding rates of 100% or more at 2000ppm and 5000ppm, while the weeding effect of 1000ppm paraquat liquid was not 100%, and the paraquat composition XR01-XR04 was diluted to 1000ppm for comparability to carry out the weeding effect test. The test plots were the same plots as the paraquat control samples, three replicates each of which was 1 square meter were set for the test plots of each paraquat composition sample for the forest test plot, and the herbicidal effect was verified as the weed mortality of piemarker and cockspur grass.
TABLE 3 herbicidal Effect of Paraquat compositions containing cellulose derivatives
As can be seen from Table 3, the addition of the cellulose derivative to paraquat does not affect the activity of paraquat, and the cellulose derivative can improve the herbicidal effect of paraquat. The 4 samples XR01-XR04 all had over 97% herbicidal effect against abutilon and cockspur grass. At the same concentration, the activity was improved by at least 5 percentage points compared to that for paraquat control composition XR05, which is a sufficient indication of the stabilization of the herbicidal activity and the improvement in the effect of the cellulose derivative on paraquat.
The foregoing examples are given for clarity of illustration only and are not limiting of the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (12)
1. A composition of paraquat for attenuating toxicity to a mammal, said composition comprising paraquat and a cellulose derivative, the cellulose derivative being a water-soluble cellulose anionic derivative.
2. A paraquat composition according to claim 1, characterised in that the weight ratio of paraquat to cellulose derivative is from 1: (0.01-5.00); preferably, the weight ratio of paraquat to cellulose derivative is 1: (0.05-1.00).
3. Paraquat composition according to claim 1, characterised in that the water-insoluble content of the water-soluble cellulose anionic derivative is less than or equal to 1.0%, preferably less than or equal to 0.5%, by weight of the cellulose anionic derivative.
4. Paraquat composition according to any one of claims 1 to 3, characterised in that the water-soluble cellulose anionic derivative is one or more of the sodium salt of cellulose sulphate, the potassium salt of cellulose sulphate, the ammonium salt of cellulose sulphate, the sodium salt of carboxymethyl cellulose, the potassium salt of carboxymethyl cellulose, the ammonium salt of carboxymethyl cellulose.
5. A paraquat composition according to claim 4, characterised in that said paraquat is 1, 1-dimethyl-4, 4-bipyridine dichloride or 1, 1-dimethyl-4, 4-bipyridine bis-methyl sulfate.
6. The paraquat composition as claimed in claim 5, wherein the sum of the weight of paraquat and the weight of the cellulose derivative is 5-99% of the weight of the paraquat composition, or the sum of the weight of paraquat and the weight of the cellulose derivative in the paraquat composition is 100-10000ppm of the weight of the paraquat composition.
7. The paraquat composition of claim 6, wherein the paraquat composition is a paraquat raw drug, a paraquat preparation or a paraquat liquid.
8. Use of a cellulose derivative which is a water-soluble cellulose anionic derivative for the preparation of a composition for attenuating toxicity to mammals.
9. Use according to claim 8, characterized in that the water-soluble cellulose anionic derivative is one or more of the sodium salt of cellulose sulphate, the potassium salt of cellulose sulphate, the ammonium salt of cellulose sulphate, the sodium salt of carboxymethyl cellulose, the potassium salt of carboxymethyl cellulose, the ammonium salt of carboxymethyl cellulose.
10. Use according to claim 8 or 9, characterized in that the weight of the cellulose derivative is 0.05 to 1.00 times the weight of paraquat, which is 1, 1-dimethyl-4, 4-bipyridine dichloride or 1, 1-dimethyl-4, 4-bipyridine bisulphate monosulphuric acid monomethyl ester salt.
11. A method for preparing a paraquat composition for reducing toxicity to mammals is characterized in that a water-soluble cellulose anion derivative is added in the process of preparing a paraquat raw drug, a mother drug and a preparation, or the water-soluble cellulose anion derivative is added after the paraquat raw drug, the mother drug and the preparation are prepared, or the water-soluble cellulose anion derivative is added in the process of diluting the paraquat preparation into a liquid drug, or the water-soluble cellulose anion derivative is added after the paraquat preparation is diluted into the liquid drug, wherein the adding amount of the water-soluble cellulose anion derivative is 0.05-1.00 times of the weight of the paraquat.
12. The method according to claim 11, characterized in that the water-soluble cellulose anionic derivative is one or more of sodium salt of cellulose sulfate, potassium salt of cellulose sulfate, ammonium salt of cellulose sulfate, sodium salt of carboxymethyl cellulose, potassium salt of carboxymethyl cellulose, ammonium salt of carboxymethyl cellulose.
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| CN103202297A (en) * | 2012-12-18 | 2013-07-17 | 江苏凯元科技有限公司 | Processing method of high-efficient paraquat paste |
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| TERUO TSUCHIYA 等: "Effectiveness of Sodium Sugar Sulfates on Acute Toxicity of Paraquat in Mice", 《JOURNAL OF PHARMACOBIO-DYNAMIC》 * |
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