CN113925643A

CN113925643A - Positioning device for building glioma model

Info

Publication number: CN113925643A
Application number: CN202111215710.2A
Authority: CN
Inventors: 孙申
Original assignee: Xuzhou Medical University
Current assignee: Xuzhou Medical University
Priority date: 2021-10-19
Filing date: 2021-10-19
Publication date: 2022-01-14

Abstract

The invention belongs to the technical field of positioning devices, and particularly relates to a positioning device for constructing a glioma model, aiming at solving the problems that in the prior art, due to the particularity of tests, the fixing of a white mouse is inconvenient, and the difficulty in carrying out glioma stock plant implantation is increased. The invention has convenient operation, is convenient for fixing the experimental mouse and reduces the difficulty of implanting the glioma stock plant.

Description

Positioning device for building glioma model

Technical Field

The invention relates to the technical field of positioning devices, in particular to a positioning device for constructing a glioma model.

Background

Glioma is caused by the interaction of congenital genetic high-risk factors and environmental carcinogenic factors, known genetic diseases such as neurofibromatosis, tuberculous sclerosis and the like are genetic susceptibility factors of brain glioma, glioma is a tumor with high malignancy, the glioma is the most common primary central nervous system tumor, and the study of brain glioma is required to be well done, and a glioma disease model is indispensable.

In the prior art, due to the specificity of the test, the fixing of the mice is inconvenient, and the difficulty in carrying out glioma original plant implantation is increased.

Disclosure of Invention

The invention aims to solve the defects that in the prior art, due to the particularity of tests, fixing of a mouse is inconvenient, and implantation of a glioma stock plant is difficult, and provides a positioning device for building a glioma model.

In order to achieve the purpose, the invention adopts the following technical scheme:

a positioning device for building a glioma model comprises a base, wherein an upright post is rotatably mounted at the top of the base, a fixing plate is mounted at the top of the upright post, a sliding groove is formed in the top of the fixing plate, a screw rod is rotatably mounted in the sliding groove, the left side of the fixing plate is connected with a servo motor, an output shaft of the servo motor is connected with the left end of the screw rod, the outer side of the screw rod is in threaded connection with a propelling block, a rack plate is slidably mounted on the propelling block, a gear is connected onto the rack plate and is rotatably connected with the propelling block, a connecting rod is mounted on the outer side of the gear, a pressure plate is mounted on the connecting rod, a massage mechanism is mounted on the inner side of the pressure plate, a reciprocating driving mechanism is connected onto the outer side of the pressure plate and is connected with the massage mechanism, a placing box is connected to the top of the fixing plate, two strip-shaped placing holes are formed in the top of the placing box, two clamping mechanisms are mounted in the placing box, the bottom of two fixture all is connected with the rotary rod, and the top of fixed plate is seted up flutedly, and the one end of screw rod extends to in the recess and links to each other with two rotary rods.

Preferably, massage mechanism includes arc and massage ball, and arc slidable mounting is in the inboard of pressure plate, and the massage ball is a plurality of and embedded inboard at the arc, and two T type pieces are installed in the outside of arc, and two T type grooves have been seted up to the inboard of pressure plate, and the inboard sliding connection in T type piece and T type groove.

Preferably, reciprocating drive mechanism is including fixed box, cylinder, motor, round bar and slide bar, fixed box installs in the outside of pressure plate, the motor is installed on the inner wall of fixed box, the one end of round bar rotates with the inner wall of fixed box to be connected, the other end of round bar links to each other with the output shaft of motor, the cylinder cover is established in the outside of round bar, the elliptical trough has been seted up in the cylindrical outside, the one end of slide bar and the inner wall sliding connection of elliptical trough, the other end and the arc of slide bar link to each other, the slide opening has been seted up on the pressure plate, slide bar and slide opening sliding connection.

Preferably, the rectangular hole has been seted up on the propulsion piece, rack plate and rectangular hole swing joint, and fixed mounting has two stoppers on the inner wall of rectangular hole, and the spacing groove has all been seted up to the both sides of rack plate, stopper and spacing groove sliding connection, and the pressure piece is installed to the end of rack plate, installs the spring between the inboard of pressure piece and the propulsion piece, and the outside fixed mounting who impels the piece has the connection piece, and the gear revolve installs on the connection piece.

Preferably, fixture includes rotary disk, two squeeze sticks, two grip blocks and two rubber pads, and the bottom of rotary disk links to each other with the top of rotary rod, and two arc extrusion grooves have been seted up at the top of rotary disk, and the inner wall sliding connection in two arc extrusion grooves of two squeeze sticks, two squeeze sticks link to each other with the bottom of two grip blocks, and two rubber pads link to each other with the inboard of two grip blocks, place the box fixed mounting and have two bracing pieces, grip block slidable mounting is in the outside of two bracing pieces.

Preferably, the bottom end of the rotating rod is provided with a worm wheel, two worms are arranged on the outer sides of the screws, and the worms are meshed with the worm wheel.

Preferably, a first power supply is installed at the bottom of the fixing plate and connected with the servo motor, a second power supply is installed on the outer side of the pressure plate and connected with the motor.

Compared with the prior art, the invention has the advantages that:

according to the scheme, the screw rod is driven to rotate through the servo motor, the screw rod drives the pushing block to move, the pushing block drives the pressure block to be close to the placing box and to be extruded, the pushing block is stressed to drive the rack plate to move, the rack plate moves to drive the gear to rotate, the gear drives the pressure plate to turn over through the connecting rod, and the pressure plate drives the arc-shaped plate to turn over to be close to the experimental mouse and to extrude and fix the back of the experimental mouse;

according to the scheme, the two rotary rods are driven to rotate by the screw, the two rotary rods drive the two rotary disks to rotate, the rotary disks extrude the two extrusion rods to be close to each other through the two arc-shaped extrusion grooves, the two extrusion rods drive the two clamping plates to be close to each other through the supporting rods, the two clamping plates drive the two rubber pads to be close to each other to fix the mouse claws, and therefore the stability of a laboratory mouse can be improved;

this scheme passes through that the motor drives the round bar rotation, and the round bar drives the cylinder rotation, and through oval slot extrusion slide bar removal, the slide bar drives arc reciprocating motion, and the arc massages the back of laboratory mouse through a plurality of massage balls, reduces laboratory mouse's catastrophe.

The invention has convenient operation, is convenient for fixing the experimental mouse and reduces the difficulty of implanting the glioma stock plant.

Drawings

FIG. 1 is a schematic structural diagram of a positioning device for constructing a glioma model according to the present invention;

FIG. 2 is an enlarged view of part A of FIG. 1;

FIG. 3 is an enlarged view of the portion B in FIG. 1;

FIG. 4 is a schematic top view of the reciprocating mechanism according to the present invention;

fig. 5 is an exploded view of the clamping mechanism according to the present invention.

In the figure: 1. a base; 2. a column; 3. a fixing plate; 4. a servo motor; 5. a chute; 6. placing the box; 7. strip-shaped placing holes; 8. a groove; 9. a screw; 10. a worm; 11. a worm gear; 12. rotating the rod; 13. rotating the disc; 14. an extrusion stem; 15. a clamping plate; 16. a rubber pad; 17. a support bar; 18. an arc-shaped extrusion groove; 19. a pressure plate; 20. an arc-shaped plate; 21. a massage ball; 22. a fixing box; 23. a cylinder; 24. a motor; 25. a round bar; 26. an elliptical trough; 27. a slide bar; 28. a slide hole; 29. a connecting rod; 30. a rack plate; 31. a gear; 32. connecting sheets; 33. a rectangular hole; 34. a limiting block; 35. a limiting groove; 36. a propulsion block; 37. a pressure block; 38. a spring; 39. a T-shaped block; 40. a T-shaped groove; 41. a first power supply; 42. a second power supply.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Example one

Referring to fig. 1-5, a positioning device for constructing a glioma model comprises a base 1, a column 2 is rotatably mounted at the top of the base 1, a fixing plate 3 is mounted at the top of the column 2, the column 2 can drive the fixing plate 3 to rotate, the angle of the fixing plate 3 can be adjusted, a chute 5 is formed at the top of the fixing plate 3, a screw 9 is rotatably mounted in the chute 5, a servo motor 4 is connected to the left side of the fixing plate 3, an output shaft of the servo motor 4 is connected to the left end of the screw 9, a pushing block 36 is in threaded connection with the outer side of the screw 9, a rack plate 30 is slidably mounted on the pushing block 36, a gear 31 is connected to the rack plate 30, the gear 31 is rotatably connected to the pushing block 36, a connecting rod 29 is mounted on the outer side of the gear 31, a pressure plate 19 is mounted on the connecting rod 29, a massage mechanism is mounted on the inner side of the pressure plate 19, and a reciprocating drive mechanism is connected to the outer side of the pressure plate 19, reciprocating drive mechanism links to each other with massage mechanism, and the top of fixed plate 3 is connected with places box 6, and the top of placing box 6 has been seted up two bars and has been placed hole 7, places and installs two fixture in the box 6, and two fixture's bottom all is connected with rotary rod 12, and the top of fixed plate 3 is seted up flutedly 8, and the one end of screw rod 9 extends to in the recess 8 and links to each other with two rotary rod 12.

In this embodiment, massage mechanism includes arc 20 and massage ball 21, arc 20 slidable mounting is in the inboard of pressure plate 19, massage ball 21 is a plurality of and embedded in the inboard of arc 20, two T type pieces 39 are installed in the outside of arc 20, two T type grooves 40 have been seted up to the inboard of pressure plate 19, the inboard sliding connection in T type piece 39 and T type groove 40, the T type piece 39 and the cooperation of T type groove 40 of setting can guarantee that arc 20 slides on pressure plate 19.

In this embodiment, the reciprocating driving mechanism includes a fixing box 22, a cylinder 23, a motor 24, a round bar 25 and a sliding bar 27, the fixing box 22 is installed on the outer side of the pressure plate 19, the motor 24 is installed on the inner wall of the fixing box 22, one end of the round bar 25 is rotatably connected with the inner wall of the fixing box 22, the other end of the round bar 25 is connected with an output shaft of the motor 24, the cylinder 23 is sleeved on the outer side of the round bar 25, an elliptical groove 26 is formed in the outer side of the cylinder 23, one end of the sliding bar 27 is slidably connected with the inner wall of the elliptical groove 26, the other end of the sliding bar 27 is connected with the arc-shaped plate 20, a sliding hole 28 is formed in the pressure plate 19, the sliding bar 27 is slidably connected with the sliding hole 28, the motor 24 drives the round bar 25 to rotate, the round bar 25 drives the cylinder 23 to rotate, the sliding bar 27 is extruded through the elliptical groove 26 to move, and the sliding bar 27 drives the arc-shaped plate 20 to reciprocate.

In this embodiment, rectangular hole 33 has been seted up on propulsion piece 36, rack plate 30 and rectangular hole 33 swing joint, fixed mounting has two stopper 34 on the inner wall of rectangular hole 33, spacing groove 35 has all been seted up to rack plate 30's both sides, stopper 34 and spacing groove 35 sliding connection, pressure piece 37 is installed to rack plate 30's end, install spring 38 between pressure piece 37's inboard and the propulsion piece 36, the outside fixed mounting who impels piece 36 has connection piece 32, gear 31 rotates and installs on connection piece 32, stopper 34 can guarantee with the cooperation of spacing groove 35 that rack plate 30 slides on rectangular hole 33.

In this embodiment, the clamping mechanism includes a rotating disk 13, two extrusion rods 14, two clamping plates 15 and two rubber pads 16, the bottom of the rotating disk 13 is connected with the top of a rotating rod 12, the top of the rotating disk 13 is provided with two arc-shaped extrusion grooves 18, the two extrusion rods 14 are slidably connected with the inner walls of the two arc-shaped extrusion grooves 18, the two extrusion rods 14 are connected with the bottoms of the two clamping plates 15, the two rubber pads 16 are connected with the inner sides of the two clamping plates 15, two support rods 17 are fixedly installed in the placing box 6, the clamping plates 15 are slidably installed on the outer sides of the two support rods 17, the bottom end of the rotating rod 12 is provided with a worm wheel 11, the outer side of the screw rod 9 is provided with two worms 10, the worm 10 is engaged with the worm wheel 11, the screw rod 9 drives the two worms 10 to rotate, the two worm wheels 11 drive the two worm wheels 11 to rotate, the two wheels 11 drive the two rotating rods 12 to rotate, the two rotating rods 12 drive the two rotating disk 13 to rotate, the rotating disc 13 extrudes the two extrusion rods 14 to be close to each other through the two arc-shaped extrusion grooves 18, the two extrusion rods 14 drive the two clamping plates 15 to be close to each other through the support of the support rod 17 to the clamping plates 15, and the two clamping plates 15 drive the two rubber pads 16 to be close to each other to fix the mouse paw.

In this embodiment, a first power source 41 is installed at the bottom of the fixing plate 3, the first power source 41 is connected to the servo motor 4, a second power source 42 is installed at the outer side of the pressure plate 19, and the second power source 42 is connected to the motor 24.

In the embodiment, when the experimental mouse placing box is used, an experimental mouse is placed on the placing box 6, four mouse claws are placed in two strip-shaped placing holes 7, the servo motor 4 is started, the servo motor 4 drives the screw rod 9 to rotate, the screw rod 9 drives the pushing block 36 to move, the pushing block 36 drives the pressure block 37 to be close to the placing box 6 and to be extruded, the pushing block 36 is forced to drive the rack plate 30 to move, the rack plate 30 moves to drive the gear 31 to rotate, the gear 31 drives the pressure plate 19 to turn over through the connecting rod 29, the pressure plate 19 drives the arc-shaped plate 20 to turn over to be close to the experimental mouse and to extrude and fix the back, meanwhile, the screw rod 9 drives the two worms 10 to rotate, the two worms 10 drive the two worm wheels 11 to rotate, the two worm wheels 11 drive the two rotary rods 12 to rotate, the two rotary rods 12 drive the two rotary disks 13 to rotate, and the rotary disks 13 extrude the two extrusion rods 14 to be close to each other through the two arc-shaped extrusion grooves 18, support through bracing piece 17 to grip block 15, two stripper bars 14 drive two grip blocks 15 and are close to each other, two grip blocks 15 drive two rubber pads 16 and are close to each other and fix the mouse claw, can increase the stability of laboratory mouse, starter motor 24, motor 24 drives the round bar 25 rotatory, round bar 25 drives cylinder 23 rotatory, it removes to extrude slide bar 27 through elliptical trough 26, slide bar 27 drives arc 20 reciprocating motion, arc 20 massages the back of laboratory mouse through a plurality of massage balls 21, reduce the degree of tension of laboratory mouse.

Example two

Referring to fig. 1-5, a positioning device for constructing a glioma model comprises a base 1, a column 2 is rotatably mounted at the top of the base 1, a fixing plate 3 is mounted at the top of the column 2, the column 2 can drive the fixing plate 3 to rotate, the angle of the fixing plate 3 can be adjusted, a chute 5 is formed at the top of the fixing plate 3, a screw 9 is rotatably mounted in the chute 5, a servo motor 4 is connected to the left side of the fixing plate 3, an output shaft of the servo motor 4 is connected to the left end of the screw 9, a pushing block 36 is in threaded connection with the outer side of the screw 9, a rack plate 30 is slidably mounted on the pushing block 36, a gear 31 is connected to the rack plate 30, the gear 31 is rotatably connected to the pushing block 36, a connecting rod 29 is mounted on the outer side of the gear 31, a pressure plate 19 is mounted on the connecting rod 29, an arc plate 20 is mounted on the inner side of the pressure plate 19, a placing box 6 is connected to the top of the fixing plate 3, place the top of box 6 and seted up two bars and place hole 7, place and install two fixture in the box 6, two fixture's bottom all is connected with rotary rod 12, and the top of fixed plate 3 is seted up flutedly 8, and the one end of screw rod 9 extends to in the flutedly 8 and links to each other with two rotary rod 12.

In this embodiment, the difference between the second embodiment and the first embodiment is: delete massage mechanism and reciprocating drive mechanism, at the inboard installation elasticity cotton of arc 20, equally can be fixed to the laboratory mouse, all structures in this application all can carry out the selection of material and length according to the in-service use condition, and the attached drawing is the schematic structure picture, and suitable adjustment can be made to specific actual size.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. The utility model provides a construct positioner for glioma model, includes base (1), stand (2) are installed in the top rotation of base (1), fixed plate (3) are installed at the top of stand (2), a serial communication port, spout (5) have been seted up at the top of fixed plate (3), screw rod (9) are installed in spout (5) internal rotation, the left side of fixed plate (3) is connected with servo motor (4), the output shaft of servo motor (4) links to each other with the left end of screw rod (9), the outside threaded connection of screw rod (9) has propulsion piece (36), propulsion piece (36) and spout (5) sliding connection, sliding mounting has rack plate (30) on propulsion piece (36), be connected with gear (31) on rack plate (30), gear (31) and propulsion piece (36) rotate to be connected, connecting rod (29) are installed to the outside of gear (31), install pressure plate (19) on connecting rod (29), massage mechanism is installed to the inboard of pressure plate (19), the outside of pressure plate (19) is connected with reciprocating drive mechanism, reciprocating drive mechanism links to each other with massage mechanism, the top of fixed plate (3) is connected with places box (6), the top of placing box (6) has been seted up two bars and has been placed hole (7), place and install two fixture in box (6), two fixture's bottom all is connected with rotary rod (12), the top of fixed plate (3) is seted up flutedly (8), the one end of screw rod (9) extends to in recess (8) and links to each other with two rotary rod (12).

2. The positioning device for building the glioma models according to claim 1, wherein the massage mechanism comprises an arc-shaped plate (20) and massage balls (21), the arc-shaped plate (20) is slidably mounted on the inner side of the pressure plate (19), and the massage balls (21) are multiple and embedded in the inner side of the arc-shaped plate (20).

3. The positioning device for building the glioma models according to claim 2, wherein two T-shaped blocks (39) are installed on the outer side of the arc-shaped plate (20), two T-shaped grooves (40) are formed on the inner side of the pressure plate (19), and the T-shaped blocks (39) are connected with the inner sides of the T-shaped grooves (40) in a sliding manner.

4. The positioning device for constructing a glioma model of claim 1, reciprocating drive mechanism includes fixed box (22), cylinder (23), motor (24), round bar (25) and slide bar (27), the outside at pressure plate (19) is installed to fixed box (22), motor (24) are installed on the inner wall of fixed box (22), the one end of round bar (25) is rotated with the inner wall of fixed box (22) and is connected, the other end of round bar (25) links to each other with the output shaft of motor (24), cylinder (23) cover is established in the outside of round bar (25), oval groove (26) have been seted up in the outside of cylinder (23), the one end of slide bar (27) and the inner wall sliding connection of oval groove (26), the other end of slide bar (27) links to each other with arc (20), draw runner (28) have been seted up on pressure plate (19), slide bar (27) and draw runner (28) sliding connection.

5. The positioning device for building the glioma model according to claim 1, wherein the pushing block (36) is provided with a rectangular hole (33), the rack plate (30) is movably connected with the rectangular hole (33), two limiting blocks (34) are fixedly mounted on the inner wall of the rectangular hole (33), both sides of the rack plate (30) are provided with limiting grooves (35), and the limiting blocks (34) are slidably connected with the limiting grooves (35).

6. The positioning device for building the glioma models according to claim 1, wherein a pressure block (37) is installed at the end of the rack plate (30), a spring (38) is installed between the inner side of the pressure block (37) and the pushing block (36), a connecting piece (32) is fixedly installed on the outer side of the pushing block (36), and the gear (31) is rotatably installed on the connecting piece (32).

7. The positioning device for building the glioma model according to claim 1, wherein the clamping mechanism comprises a rotating disk (13), two extrusion rods (14), two clamping plates (15) and two rubber pads (16), the bottom of the rotating disk (13) is connected with the top of the rotating rod (12), the top of the rotating disk (13) is provided with two arc-shaped extrusion grooves (18), the two extrusion rods (14) are slidably connected with the inner walls of the two arc-shaped extrusion grooves (18), the two extrusion rods (14) are connected with the bottoms of the two clamping plates (15), and the two rubber pads (16) are connected with the inner sides of the two clamping plates (15).

8. The positioning device for building the glioma models according to claim 7, wherein two support rods (17) are fixedly arranged in the placing box (6), and the clamping plate (15) is slidably arranged at the outer sides of the two support rods (17).

9. The positioning device for building the glioma model according to claim 1, wherein the bottom end of the rotating rod (12) is provided with a worm wheel (11), the outer side of the screw rod (9) is provided with two worms (10), and the worms (10) are meshed with the worm wheel (11).

10. The positioning device for building the glioma model according to claim 1, wherein a first power supply (41) is installed at the bottom of the fixing plate (3), the first power supply (41) is connected with the servo motor (4), a second power supply (42) is installed at the outer side of the pressure plate (19), and the second power supply (42) is connected with the motor (24).