CN113925021B - Animal sleep rhythm regulation and control test method - Google Patents
Animal sleep rhythm regulation and control test method Download PDFInfo
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Abstract
The application provides a test method for regulating and controlling animal sleep rhythm. The animal sleep rhythm control test method comprises the following steps: acquiring basic physiological information of animals; obtaining a grading model; inputting basic physiological information of the animal into a scoring model, thereby obtaining animal scoring; acquiring a regulation database, wherein the regulation database comprises at least one sleep rhythm regulation scheme and at least one preset score, and the sleep rhythm regulation scheme is at least associated with the preset score; and judging whether the obtained animal score is the same as one preset score in all preset scores in the adjustment database, if so, obtaining a sleep rhythm adjustment scheme associated with the preset score which is the same as the animal score, and controlling a sleep rhythm regulation and control test system to work according to the sleep rhythm adjustment scheme. The animal sleep rhythm regulation and control test method selects a proper sleep rhythm regulation scheme according to the basic physiological information of the animal, and can be matched with the body condition of the animal to the greatest extent.
Description
Technical Field
The application belongs to the technical field of animal test assistance, and particularly relates to an animal sleep rhythm regulation test method.
Background
In animal neurological function and mechanism studies, it is sometimes desirable to artificially regulate animal sleep, for example, to wake an animal when it enters sleep, or to wake an animal on a regular basis, and to monitor the animal's sleep under various environmental conditions.
In the prior art, a user usually needs manual control or instrument interference to wake up animals, and the mode is time-consuming and labor-consuming, and the model itself and the actual situation generated by sleep rhythm disorder have large difference. Moreover, the user usually does not consider the actual condition of the animal, such as the heart condition, blood oxygen condition and other conditions of the animal, so that on one hand, the reasonable sleep control cannot be performed according to the actual condition of the animal, and on the other hand, the animal is easily damaged, for example, if the sleep rhythm control test is also performed when the heart of the animal is in a problem, the animal may be damaged.
Accordingly, a technical solution is desired to overcome or at least alleviate at least one of the above-mentioned drawbacks of the prior art.
Disclosure of Invention
It is an object of the present application to provide a method of testing sleep rhythm control in animals to address at least one of the above problems.
In a first aspect of the application, an animal sleep rhythm control test method is used for controlling a sleep rhythm control test system to provide a sleep rhythm control environment for an animal, wherein the animal is positioned in a sleep rhythm control test device; the animal sleep rhythm regulation test method comprises the following steps:
acquiring basic physiological information of animals;
obtaining a scoring model;
inputting the basic physiological information of the animal into the scoring model, thereby obtaining an animal score;
acquiring a regulation database, wherein the regulation database comprises at least one sleep rhythm regulation scheme and at least one preset score, and the sleep rhythm regulation scheme is at least associated with the preset score;
judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database, if so, judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database, and if so, judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database
And acquiring a sleep rhythm regulation scheme associated with a preset score which is the same as the animal score, and controlling a sleep rhythm regulation and control test system to work according to the sleep rhythm regulation scheme.
Optionally, the animal basic physiological information includes animal body temperature information, animal oxygen content information, animal heart rate information, animal non-sleep time length information, and animal excitation information.
Optionally, the sleep rhythm regulation scheme includes at least one or more of the following:
the first scheme is as follows: the stimulation is carried out every 30 minutes within 48 hours under the illumination of 40w intensity, and each time lasts for 30 minutes; every 1 hour with 80 to 90 db of noise, 5 minutes each time;
the second scheme is as follows: light 60w intensity stimulation was performed every 20 minutes for 30 minutes each time over 36 hours, with 90 to 110 db noise every 1 hour for 2 minutes each time;
the third scheme is as follows: the light 50w intensity stimulation was performed every 10 minutes for 50 minutes with 50 to 70 db noise every 1 hour for 10 minutes over 72 hours.
Optionally, in the process of controlling the work of the sleep rhythm control test device according to the sleep rhythm control scheme, the animal sleep rhythm control test method further comprises the following steps:
acquiring animal image information;
identifying the animal image information and judging whether the animal goes to sleep or not; if so, then
Generating an electrical stimulation signal and transmitting the electrical stimulation signal to an electrical stimulation system.
Optionally, the identifying the animal image information and determining whether the animal falls to sleep includes:
acquiring animal image information for multiple times at preset time intervals;
identifying whether the eyes of the animals in the animal image information obtained at each time are closed, if so, identifying whether the eyes of the animals in the animal image information are closed
And judging that the animal enters sleep.
Optionally, in the process of controlling the work of the sleep rhythm control test device according to the sleep rhythm control scheme, the animal sleep rhythm control test method further comprises the following steps:
acquiring the oxygen content in the sleep rhythm regulation test device;
and when the oxygen content is lower than a preset threshold value, generating an oxygen supply signal and transmitting the oxygen supply signal to the sleep rhythm regulation test system to improve the oxygen content in the sleep rhythm regulation test device.
The application also provides an animal sleep rhythm control test device, animal sleep rhythm control test device includes:
the physiological information acquisition module is used for acquiring basic physiological information of the animal;
the scoring model acquisition module is used for acquiring a scoring model;
the scoring module is used for inputting the basic physiological information of the animal into the scoring model so as to obtain animal scoring;
a conditioning database acquisition module for acquiring a conditioning database, the conditioning database comprising at least one sleep rhythm conditioning regimen and at least one preset score, one sleep rhythm conditioning regimen being associated with at least one preset score;
the judgment module is used for judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database or not;
and the execution module is used for acquiring the sleep rhythm regulation scheme under the condition that the judgment module judges that the judgment module exists, and controlling the sleep rhythm regulation and control test device to work according to the sleep rhythm regulation scheme.
The present application also provides a sleep rhythm control test system, the sleep rhythm control test system includes:
the box comprises a closed box body, wherein an accommodating space is arranged in the closed box body;
the conductive plate is arranged in the accommodating space and is suitable for placing a test animal;
the power supply system is connected with the conductive plate and is used for providing stimulation current for the conductive plate;
the animal basic information detection device is used for detecting basic physiological information of the animal;
the animal sleep rhythm control test device is connected with the power supply system, the oxygen supply device, the sound source, the oxygen detector, the temperature and humidity detection device, the illumination device and the camera device respectively and is used for providing working signals for the devices connected with the animal sleep rhythm control test device;
one end of the oxygen supply pipe extends into the accommodating space;
the apparatus of oxygen suppliment, the apparatus of oxygen suppliment with the other end of oxygen suppliment pipe is connected, the apparatus of oxygen suppliment is used for passing through the oxygen suppliment pipe does accommodation space provides oxygen.
A microphone disposed within the accommodating space;
the sound source is connected with the loudspeaker;
the oxygen detector is arranged in the accommodating space and used for detecting the oxygen content in the accommodating space;
the temperature and humidity detection device is arranged in the accommodating space and is used for detecting the temperature and the humidity in the accommodating space;
an illumination device disposed within the accommodation space;
the number of the camera devices is multiple, and the camera devices are distributed in the accommodating space.
Optionally, the animal basic information detection device includes:
a heart rate monitoring device for detecting animal heart rate information of an animal;
the system comprises a blood oxygen saturation monitor, a data acquisition module and a data processing module, wherein the blood oxygen saturation monitor is used for detecting animal oxygen content information of animals.
The animal sleep rhythm control test method has the advantages that: 1) The sleep rhythm disorder models of different strains of animals can be conveniently and effectively constructed, and a great deal of energy and labor of experimental researchers are saved; 2) The appropriate sleep rhythm regulation scheme can be selected according to the basic physiological information of the animal, the matching with the self body condition of the animal can be carried out to the maximum extent, the animal is prevented from being injured, and the test model can be more accurate; 3) According to research needs, a plurality of or one mode can be selected to construct a sleep rhythm disorder model, and a scheme can be flexibly formulated and adjusted, so that the requirements of various aspects of experiments can be more comprehensively met; 4) The sleep process is adjusted by adopting various factors and modes which are common in daily life and influence the sleep, compared with the existing adjusting method, the sleep process is more in line with the actual situation, the interference of other factors is avoided, and the modeling and research results are more convincing.
Drawings
FIG. 1 is a schematic flow chart of a method for testing sleep rhythm regulation in an animal according to one embodiment of the present application;
FIG. 2 is a schematic structural diagram of a sleep rhythm control test device according to an embodiment of the present application;
FIG. 3 is another schematic structural diagram of a sleep rhythm control test device according to an embodiment of the present application;
FIG. 4 is another schematic diagram of a sleep rhythm control test device according to an embodiment of the present application;
fig. 5 is an exemplary block diagram of an electronic device capable of implementing an animal sleep rhythm control test method provided according to an embodiment of the present application.
Reference numerals:
1. a closed box body; 2. a conductive plate; 3. an oxygen supply tube; 4. an oxygen supply device; 5. a loudspeaker; 6. a sound source; 7. a base plate; 8. a glass cover; 9. a vacuum pumping device; 10. an oxygen detector; 11. a temperature and humidity detection device; 12. an illumination device; 13. a camera device; 14. a heating device.
Detailed Description
In order to make the implementation objects, technical solutions and advantages of the present application clearer, the technical solutions in the embodiments of the present application will be described in more detail below with reference to the drawings in the embodiments of the present application. In the drawings, the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The described embodiments are a subset of the embodiments in the present application and not all embodiments in the present application. The embodiments described below with reference to the accompanying drawings are illustrative and intended to explain the present application and should not be construed as limiting the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application. Embodiments of the present application will be described in detail below with reference to the accompanying drawings.
It should be noted that the terms "first" and "second" in the description of the present invention are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Fig. 1 is a schematic flow chart of an animal sleep rhythm control test method provided in one embodiment of the present application.
The animal sleep rhythm control test method shown in fig. 1 is used for controlling a sleep rhythm control test system to provide a sleep rhythm control environment for animals, and the animals are positioned in a sleep rhythm control test device.
In this example, the animal sleep rhythm control test method comprises:
step 1: acquiring basic physiological information of animals;
and 2, step: obtaining a scoring model;
and step 3: inputting basic physiological information of the animal into a scoring model so as to obtain animal scoring;
and 4, step 4: acquiring a regulation database, wherein the regulation database comprises at least one sleep rhythm regulation scheme and at least one preset score, and the sleep rhythm regulation scheme is at least associated with the preset score;
and 5: judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database, if so, judging that the animal score is the same as one preset score in all preset scores in the regulation database
And 6: and acquiring a sleep rhythm regulation scheme associated with a preset score which is the same as the animal score, and controlling the work of a sleep rhythm regulation and control test system according to the sleep rhythm regulation scheme.
The animal sleep rhythm regulation and control test method selects a proper sleep rhythm regulation scheme according to the basic physiological information of the animal, can be matched with the body condition of the animal to the greatest extent, prevents the animal from being injured, and can enable the test to be more accurate.
In this embodiment, the basic animal physiological information includes animal body temperature information, animal oxygen content information, animal heart rate information, animal non-sleep time information, and animal excitation information.
In this embodiment, the scoring model is:
the sleep rhythm regulation and control effect is implemented by adopting a scoring accumulation method, and the regulation and control indexes comprise 6 parts of animal body temperature information (T) and animal blood oxygen saturation information (SaO) 2 ) The method comprises the following steps of obtaining animal heart rate information (H), animal sleep-free duration information (W), animal movement path distance information (D) and animal chest and abdomen movement conditions (B). The calculation formula of the total score is as follows: sigma Score =（W/36）+〔log 1.3 T 0 - log 1.3 （T Average ）〕* γ 1 +〔log 0.65 （S Average ）- log 0.65 S 0 〕* γ 2 + 〔log 4.5 H 0 - log 4.5 （H Average ）〕* γ 3 +（log 2000 D 0 - log 2000 D）* γ 4 +〔lgB 0 -lg（B Average ）〕* γ 5 The total score is the sum of 6 parts, each part is scored according to-1 to 2 scores, and each part is accumulated to obtain the total score of-5 to 12. Higher total score indicates more significant effect in regulating sleep rhythm in animals. Before the test, the coefficient (gamma) for scoring should be determined according to different types of test animals (such as different varieties of large mice, etc.) 1-5 ) The values of (1), each index having a reference value (T) according to the experimental protocol and the animal species 0 ，S 0 ，H 0 ，W 0 ，D 0 And B 0 Table 2), each index is measured multiple times and averaged (e.g., body temperature can be measured three times, i.e., T1, T2, T3, and T is obtained by dividing by 3 Average ). In this embodiment, the reference value of the animal body temperature information is T 0 The reference value of the blood oxygen saturation information of the animal is S 0 The animal heart rate information reference value is H 0 Time period when animal is not sleepingInformation reference value is W 0 The reference value of the animal movement path distance information is D 0 The reference value of the chest and abdomen movement condition of the animal is B 0 ；T Average Is the mean value of body temperature, S Average The average value of the blood oxygen saturation information of the animal, the average value of the H average information of the heart rate of the animal, B Average out The average value of the motion conditions of the chest and the abdomen of the animal, D is the motion path distance of the animal, and W is the information of the duration of the animal not sleeping; total (Σ) Score ) Normal, unregulated animals are defined at 0-2 points; regulating and controlling the implementation animals at 3-5; a score of 6 or more (or equal to) is defined as an animal with a successful sleep rhythm control.
TABLE 1 Scoring coefficient (gamma) for animals of different strains 1-5 ) Value taking
TABLE 2 reference values for the indices of different animal strains
For example, when the animal body temperature is normal, the score is 0-1, and when the animal body temperature is low, the score is 1-2; when the body temperature of the animal is higher, the score is-1 to 0. For example, normal rat animals have a body temperature of 38.5 ℃ (normal range 37.8-39.0 ℃), a body temperature of 0-2 minutes below 38.5 ℃, and a body temperature of-1-0 minutes when the animal is in a high temperature or warm state, e.g., above 38.5 ℃.
For example, when the blood oxygen saturation level of an animal is 99% to 100%, the blood oxygen saturation level of the animal is considered to be normal, and the score is 0 to 1, while when the blood oxygen saturation level is less than 98%, for example, 80% to 98%, the score is 1 to 2, and when the blood oxygen saturation level is more than 99.5%, the score is-1 to 0.
For example, when the heart rate information of the animal is in a normal state, the score is 0 to 1, when the heart rate information is slow, the score is 1 to 2, when the heart rate information is fast, the score is-1 to 0, for example, when the heart rate of a normal rat is 360 times/minute, the score is 0 to 1, when the heart rate is 260 or less, the score is 1 to 2, and when the heart rate is more than 450, the score is-1 to 0.
For example, when the movement path and distance information of the animal are the same as those in the conventional state, 0 to 1 point is obtained, for example, when the mouse has a distance of 10000 m/day in the normal state, 8000 m/day to 10000 m/day are in the normal state, 0 to 1 point is obtained, and if it is less than 8000 m, 1 to 2 points are obtained, and if it is more than 10000 m/day, 1 to 0 point is obtained.
For example, when the experimental protocol designed the animal had a sleep deprivation duration of 36 hours, a score of 1 was obtained; when the sleep deprivation time of the animals is 48 hours according to the experimental scheme, 1.5 points are obtained; when the experimental protocol designed the animal had a length of sleep deprivation of 72 hours or more, 2 points were obtained.
For example, the abdominal exercise information of the animal is 0 to 1 point if it is the same as the normal state, and 1 to 2 points if it is lower than the normal value, for example, the abdominal exercise frequency of the rat is 130 times/minute per minute which is normal, 0 to 1 point is obtained, 1 to 2 points if it is lower than 100 times per minute is obtained, and-1 to 0 points if it is higher than 150 times per minute is obtained.
Calculating scores by using a formula according to the obtained data, and obtaining the final score, wherein the total score is defined as a normal unregulated animal in a score of 0-2; regulating and controlling the animals at 3-5; animals with a score of 6 or more are defined as animals with a successful sleep rhythm control.
In this embodiment, the sleep rhythm regulation scheme includes at least one or more of the following:
the first scheme is as follows: within 48 hours, the stimulation is carried out every 30 minutes by illumination with 40w intensity, each time lasts for 30 minutes, and the stimulation is carried out every 1 hour by noise of 80-90 dB, each time lasts for 5 minutes;
the second scheme is as follows: within 36 hours, the light 60w intensity stimulation is carried out every 20 minutes, each time lasts for 30 minutes, and the noise is 90-110 decibels every 1 hour and each time lasts for 2 minutes;
the third scheme is as follows: light 50w intensity stimulation was performed every 10 minutes for 72 hours, each for 50 minutes, with noise 50 to 70 db every 1 hour, each for 10 minutes.
It is understood that the user may set other sleep rhythm adjustment regimens according to his or her needs, and it is understood that one sleep rhythm adjustment regimen may be associated with one preset score or a plurality of preset scores, for example, in one embodiment, the preset score is 0 to 100, wherein the first regimen is associated with 0 to 40, the first regimen is used when the animal score is 30, the second regimen is associated with 41 to 70, the third regimen is associated with 71 to 100 when the animal score is 56, the third regimen is used when the animal score is 80.
In this embodiment, the animal sleep rhythm control test method further comprises, during the controlling of the operation of the sleep rhythm control test device according to the sleep rhythm control program:
acquiring animal image information;
identifying the animal image information and judging whether the animal falls asleep or not; if so, then
Generating an electrical stimulation signal and transmitting the electrical stimulation signal to an electrical stimulation system.
In the above-mentioned sleep rhythm regulation scheme, the animal may move according to the will of the user, for example, the animal cannot sleep due to the above-mentioned various interferences, however, the sleep of the animal may not be affected by the above-mentioned various interferences, at this time, if the animal is judged to be sleeping, an electrical stimulation signal is generated and transmitted to the electrical stimulation system, and the power supply system in the electrical stimulation system supplies power to the conductive plate, so as to stimulate the animal on the conductive plate, thereby waking up the animal.
In this embodiment, identifying the animal image information and determining whether the animal is asleep includes:
acquiring animal image information for multiple times at preset time intervals;
identifying whether the animals in the animal image information obtained at each time are all closed eyes, if yes, then
And judging that the animal enters the sleep.
For example, within 5 minutes, image information of the animal is acquired every 30 seconds, if it is identified that the animal is in a closed eye state through the image information (whether the animal is in a closed eye state or not can be acquired through image identification, and the animal can be acquired through artificial image observation), if so, the animal is judged to sleep.
In this embodiment, in controlling the operation of the sleep rhythm control test device according to the sleep rhythm control program, the animal sleep rhythm control test method further includes:
acquiring the oxygen content in the sleep rhythm regulation test device;
and when the oxygen content is lower than the preset threshold value, generating an oxygen supply signal and transmitting the oxygen supply signal to the sleep rhythm regulation test system to improve the oxygen content in the sleep rhythm regulation test device.
The application also provides an animal sleep rhythm control test device which comprises a physiological information acquisition module, a grading model acquisition module, a grading module, an adjustment database acquisition module, a judgment module and an execution module; wherein,
the physiological information acquisition module is used for acquiring basic physiological information of the animal;
the scoring model acquisition module is used for acquiring a scoring model;
the scoring module is used for inputting basic physiological information of the animal into the scoring model so as to obtain the animal score;
the adjustment database acquisition module is used for acquiring an adjustment database, the adjustment database comprises at least one sleep rhythm adjustment scheme and at least one preset score, and one sleep rhythm adjustment scheme is at least associated with one preset score;
the judgment module is used for judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database;
and the execution module is used for acquiring a sleep rhythm regulation scheme under the condition that the judgment module judges that the judgment module exists, and controlling the sleep rhythm regulation and control test device to work according to the sleep rhythm regulation scheme.
The application also provides an electronic device, which comprises a memory, a processor and a computer program stored in the memory and capable of running on the processor, wherein the processor executes the computer program to realize the animal sleep rhythm control test method.
The present application also provides a computer-readable storage medium storing a computer program which, when executed by a processor, enables the animal sleep rhythm control test method as described above.
Referring to fig. 2 to 4, the application further provides a sleep rhythm control test system, which comprises a closed box body 1, a conductive plate 2, a power supply system, an animal basic information detection device, an animal sleep rhythm control test device, an oxygen supply pipe 3, an oxygen supply device 4, a loudspeaker 5, a sound source 6, an oxygen detector 10, a temperature and humidity detection device 11, an illumination device 12 and a camera device 13. Wherein,
the closed box body is internally provided with an accommodating space;
the conductive plate is arranged in the accommodating space, and the conductive plate is suitable for placing a test animal;
the power supply system is connected with the conductive plate and is used for providing stimulating current for the conductive plate;
the animal basic information detection device is used for detecting the basic physiological information of the animal;
the animal sleep rhythm control test device is connected with the power supply system, the oxygen supply device, the sound source, the oxygen detector, the temperature and humidity detection device, the lighting device and the camera device respectively and is used for providing working signals for the devices connected with the animal sleep rhythm control test device;
one end of the oxygen supply pipe extends into the accommodating space;
the apparatus of oxygen suppliment with the other end of oxygen supply pipe is connected, and the apparatus of oxygen suppliment is used for providing oxygen for accommodation space through oxygen supply pipe.
The loudspeaker is arranged in the accommodating space;
the sound source is connected with the loudspeaker;
the oxygen detector is arranged in the accommodating space and used for detecting the oxygen content in the accommodating space;
the temperature and humidity detection device is arranged in the accommodating space and used for detecting the temperature and the humidity in the accommodating space;
the lighting device is arranged in the accommodating space;
the number of the camera devices is multiple, and the camera devices are distributed in the accommodating space.
In this embodiment, the animal basic information detecting apparatus includes:
a heart rate monitoring device for detecting animal heart rate information of an animal; in this embodiment, the heart rate monitoring device adopts a mode of implanting electrodes subcutaneously, and the technology is the prior art and is not described herein again.
The system comprises a blood oxygen saturation monitor, a data processing unit and a data processing unit, wherein the blood oxygen saturation monitor is used for detecting animal oxygen content information of an animal;
the thermometer is used for detecting the body temperature of the animal.
In this embodiment, the basic physiological information of the animal includes animal body temperature information, animal oxygen content information, animal heart rate information, animal sleepless time length information, and animal excitation information, wherein,
animal body temperature information is obtained by a thermometer, and it can be understood that the thermometer can be a non-contact thermometer or a contact thermometer.
In the embodiment, the animal oxygen content information is obtained by a blood oxygen saturation monitor;
in this embodiment, animal heart rate information is obtained by a heart rate monitoring device;
in the embodiment, the information of the animal sleep time length is acquired by the camera device;
in this embodiment, the animal excitation information is obtained by the image capturing device, specifically, the image capturing device monitors the animal excitation information in real time, wherein the image capturing device has a timing function, when the controller in the image capturing device recognizes that the animal is moving through the image information provided by the image capturing device, the animal is considered not to be asleep, or whether the animal is not asleep is determined through the closed-eye information, and the moving speed of the animal, for example, whether the animal is running or walking or is still in place, can also be recognized through the image information.
The sleep rhythm regulation and control test system shown in fig. 2 to 4 comprises a closed box body 1, a conductive plate 2 and a power supply system, wherein an accommodating space is arranged in the closed box body 1; the conductive plate 2 is arranged in the accommodating space, and the conductive plate is suitable for placing a test animal; the power supply system is connected with the conductive plate and used for providing stimulation current for the conductive plate.
The power supply system among the sleep rhythm control test device of this application provides amazing current for the current conducting plate (can not harm the animal and can provide certain amazing current for the animal) to wake up the animal, thereby control the sleep rhythm of animal, with the reaction of observing the animal, and then study animal's nervous system.
Referring to fig. 2 to 4, in the present embodiment, the sleep rhythm control test device further includes an oxygen supply tube 3 and an oxygen supply device 4, wherein one end of the oxygen supply tube 3 extends into the accommodating space; the oxygen supply device 4 is connected with the other end of the oxygen supply tube 3, and the oxygen supply device 4 is used for supplying oxygen to the accommodating space through the oxygen supply tube 3.
Adopt this kind of mode, can carry out oxygen concentration through the apparatus of oxygen suppliment and adjust, according to the experimental demand, increase the oxygen volume or the reduction oxygen volume of the accommodation space of whole seal box body.
In this embodiment, the accommodating space in the enclosure box body is isolated from the external space, i.e., in a closed state.
Referring to fig. 2 to 4, in the present embodiment, the sleep rhythm control test device further includes a microphone 5 and a sound source 6, the microphone 5 being disposed in the accommodating space; the sound source 6 is connected to a loudspeaker.
In this way, the animal can be woken up acoustically, so that the sleep of the animal can be regulated acoustically, and in addition, the acoustic can be high-frequency acoustic or low-frequency acoustic, so that the test of various sounds of the animal during the sleep can be known.
Referring to fig. 3, in the present embodiment, the enclosure box body includes a bottom plate 7 and a glass cover 8, the glass cover 8 covers the bottom plate 7, and the glass cover 8 and the bottom plate 7 surround to form an accommodating space; the conductive plate 2 is disposed on the bottom plate 7.
With this arrangement, the user can see the condition in the accommodating space inside the glass cover.
Referring to fig. 2-4, in the present embodiment, the enclosure body further includes a base on which the bottom panel is mounted.
In this embodiment, the oxygen supply apparatus is mounted on a base.
In this embodiment, the base includes a base body and a base baffle group, and the base body is hollow inside for various circuits to be placed.
In this embodiment, the base baffle group is disposed on the base, and the oxygen supply device and the sound source are mounted on the base baffle group.
Referring to fig. 4, in the present embodiment, the sleep rhythm control test device further includes a vacuum pumping device 9, and the vacuum pumping device 9 is installed on the base plate 7 for vacuumizing the accommodation space.
Through setting up evacuating device, can carry out the atmospheric pressure regulation in the accommodation space to know the sleep condition of animal under different pressure state.
In this embodiment, the sleep rhythm control test device further includes an oxygen detector 10, and the oxygen detector 10 is disposed in the accommodating space and is used for detecting the oxygen content in the accommodating space.
Through setting up the oxygen detector, can know the oxygen content in the accommodation space in real time.
Referring to fig. 4, in this embodiment, the sleep rhythm control testing device further includes a temperature and humidity detecting device 11, and the temperature and humidity detecting device 11 is disposed in the accommodating space and used for detecting the temperature and humidity in the accommodating space.
Temperature and humidity in the accommodation space can be monitored in real time by arranging the temperature and humidity detection device.
Referring to fig. 2, in the present embodiment, the sleep rhythm control test device further includes an illumination device 12, and the illumination device 12 is disposed in the accommodating space.
Through setting up lighting device, can observe the sleep state of animal under the condition of different light intensity.
Referring to fig. 2, in the present embodiment, the sleep rhythm control test device further includes a plurality of image pickup devices 13, and the image pickup devices 13 are distributed in the accommodating space.
The camera device can enable a user to observe the situation in the accommodating space at a long distance.
Referring to fig. 2, in the present embodiment, the sleep rhythm control test device further includes a heating device 14 disposed in the glass cover for heating the accommodating space in the glass cover.
The temperature and the humidity in the receiving space can be changed by the heating device.
This application still includes total controller, and total controller is connected with power supply system, oxygen suppliment device, sound source 6, evacuating device 9, oxygen gas detection appearance 10, temperature and humidity detection device 11, lighting device 12, camera device 13 and heating device 14 respectively.
In actual use, the general controller can receive the information transmitted by each device connected with the general controller and control each device according to the control logic of the general controller.
For example, the master controller obtains the oxygen content detected by the oxygen detector, and sends a working signal to the oxygen supply device when the oxygen content is lower than a preset oxygen threshold in the master controller, so that the oxygen supply device works.
For another example, the master controller obtains temperature information and/or humidity information provided by the temperature and humidity detection device, and provides a working signal for the heating device when the temperature is lower than the preset temperature in the master controller, so that the heating device is heated.
By adopting the mode, on one hand, the adjustment of various environmental factors can be carried out according to the self condition, on the other hand, various devices can be started when needed, thereby preventing the unnecessary waste of various devices and saving resources.
Fig. 5 is an exemplary block diagram of an electronic device capable of implementing a load balancing method based on a graph-convolution neural network and deep reinforcement learning according to an embodiment of the present application.
As shown in fig. 5, the electronic device includes an input device 501, an input interface 502, a central processor 503, a memory 504, an output interface 505, and an output device 506. The input interface 502, the central processing unit 503, the memory 504 and the output interface 505 are connected to each other through a bus 507, and the input device 501 and the output device 506 are connected to the bus 507 through the input interface 502 and the output interface 505, respectively, and further connected to other components of the electronic device. Specifically, the input device 501 receives input information from the outside and transmits the input information to the central processor 503 through the input interface 502; the central processor 503 processes input information based on computer-executable instructions stored in the memory 504 to generate output information, temporarily or permanently stores the output information in the memory 504, and then transmits the output information to the output device 506 through the output interface 505; the output device 506 outputs the output information to the outside of the electronic device for use by the user.
That is, the electronic device shown in fig. 5 may also be implemented to include: a memory storing computer-executable instructions; and one or more processors which, when executing the computer executable instructions, may implement the animal sleep rhythm control test method described in connection with fig. 1.
In one embodiment, the electronic device shown in FIG. 5 may be implemented to include: a memory 504 configured to store executable program code; one or more processors 503 configured to execute executable program code stored in memory 504 to perform the animal sleep rhythm control test method of the above-described embodiments.
In a typical configuration, a computing device includes one or more processors (CPUs), input/output interfaces, network interfaces, and memory.
The memory may include forms of volatile memory in a computer readable medium, random Access Memory (RAM) and/or non-volatile memory, such as Read Only Memory (ROM) or flash memory (flash RAM). Memory is an example of a computer-readable medium.
Computer-readable media include both permanent and non-permanent, removable and non-removable media, and may implement information storage by any method or technology. The information may be computer readable instructions, data structures, modules of a program, or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static Random Access Memory (SRAM), dynamic Random Access Memory (DRAM), other types of Random Access Memory (RAM), read Only Memory (ROM), electrically Erasable Programmable Read Only Memory (EEPROM), flash memory or other memory technology, compact disc read only memory (CD-ROM), digital Versatile Disks (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices, or any other non-transmission medium that can be used to store information that can be accessed by a computing device.
As will be appreciated by one skilled in the art, embodiments of the present application may be provided as a method, system, or computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and so forth) having computer-usable program code embodied therein.
Furthermore, it will be obvious that the term "comprising" does not exclude other elements or steps. A plurality of units, modules or devices recited in the device claims may also be implemented by one unit or overall device by software or hardware. The terms first, second, etc. are used to identify names, but not any particular order.
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks identified in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The Processor in this embodiment may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, a discrete Gate or transistor logic device, a discrete hardware component, and so on. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.
The memory may be used to store computer programs and/or modules, and the processor may implement various functions of the apparatus/terminal device by executing or performing the computer programs and/or modules stored in the memory, as well as invoking data stored in the memory. The memory may mainly include a storage program area and a storage data area, wherein the storage program area may store an operating system, an application program required by at least one function (such as a sound playing function, an image playing function, etc.), and the like; the storage data area may store data (such as audio data, a phonebook, etc.) created according to the use of the cellular phone, etc. In addition, the memory may include high speed random access memory, and may also include non-volatile memory, such as a hard disk, a memory, a plug-in hard disk, a Smart Media Card (SMC), a Secure Digital (SD) Card, a Flash memory Card (Flash Card), at least one magnetic disk storage device, a Flash memory device, or other volatile solid state storage device.
In this embodiment, the module/unit integrated with the apparatus/terminal device may be stored in a computer-readable storage medium if it is implemented in the form of a software functional unit and sold or used as a separate product. Based on such understanding, all or part of the flow of the method according to the embodiments of the present invention may also be implemented by hardware related to instructions of a computer program, and the computer program may be stored in a computer readable storage medium, and when the computer program is executed by a processor, the steps of the method embodiments described above may be implemented. Wherein the computer program comprises computer program code, which may be in the form of source code, object code, an executable file or some intermediate form, etc. The computer readable medium may include: any entity or device capable of carrying computer program code, recording medium, U.S. disk, removable hard disk, magnetic diskette, optical disk, computer Memory, read-Only Memory (ROM), random Access Memory (RAM), electrical carrier wave signal, telecommunications signal, software distribution medium, etc.
It should be noted that the computer readable medium may contain content that is subject to appropriate increase or decrease as required by legislation and patent practice in the jurisdiction. Although the present application has been described with reference to the preferred embodiments, it is not intended to limit the present application, and those skilled in the art can make variations and modifications without departing from the spirit and scope of the present application.
Finally, it should be pointed out that: the above examples are only intended to illustrate the technical solution of the present invention, and not to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. An animal sleep rhythm control test method is used for controlling a sleep rhythm control test system to provide a sleep rhythm control environment for animals, and the animals are positioned in a sleep rhythm control test device; the animal sleep rhythm regulation test method is characterized by comprising the following steps:
acquiring basic physiological information of animals;
obtaining a grading model;
inputting the basic physiological information of the animal into the scoring model, thereby obtaining animal scoring;
acquiring a regulation database, wherein the regulation database comprises at least one sleep rhythm regulation scheme and at least one preset score, and the sleep rhythm regulation scheme is at least associated with the preset score;
judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database, if so, judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database, and if so, judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database
Acquiring a sleep rhythm regulation scheme associated with a preset score which is the same as the animal score, and controlling a sleep rhythm regulation test system to work according to the sleep rhythm regulation scheme; wherein,
the basic physiological information of the animal comprises animal body temperature information, animal blood oxygen saturation information, animal heart rate information, animal sleep time length information, animal movement path and distance information and animal chest and abdomen movement information;
the sleep rhythm regulation scheme includes at least one or more of the following:
the first scheme is as follows: within 48 hours, the stimulation is carried out every 30 minutes by illumination with 40w intensity, each time lasts for 30 minutes, and the stimulation is carried out every 1 hour by noise of 80-90 dB, each time lasts for 5 minutes;
the second scheme is as follows: within 36 hours, the light 60w intensity stimulation is performed every 20 minutes, each time lasts for 30 minutes, and the noise is 90-110 decibels, and every 1 hour is performed every 2 minutes;
the third scheme is as follows: within 72 hours, the stimulation with the intensity of 50w of light is carried out every 10 minutes, each time lasts for 50 minutes, and the stimulation with the noise of 50-70 decibels is carried out every 1 hour, each time lasts for 10 minutes;
in the process of controlling the work of the sleep rhythm control test device according to the sleep rhythm control scheme, the animal sleep rhythm control test method further comprises the following steps:
acquiring animal image information;
identifying the animal image information and judging whether the animal goes to sleep or not; if so, then
Generating an electrical stimulation signal and transmitting the electrical stimulation signal to an electrical stimulation system;
the scoring model is as follows:
Σ Score =（W/36）+〔log 1.3 T 0 - log 1.3 （T average ）〕* γ 1 +〔log 0.65 （S Average ）- log 0.65 S 0 〕* γ 2 + 〔log 4.5 H 0 - log 4.5 （H Average ）〕* γ 3 +（log 2000 D 0 - log 2000 D）* γ 4 +〔lgB 0 -lg（B Average ）〕* γ 5 (ii) a Wherein,
the reference value of the animal body temperature information is T 0 The reference value of the blood oxygen saturation information of the animal is S 0 And the animal heart rate information reference value is H 0 The reference value of the information of the non-sleeping time length of the animal is W 0 The reference value of the animal movement path distance information is D 0 The reference value of the chest and abdomen movement condition of the animal is B 0 ；T Average Is the mean value of body temperature, S Average out The average value of the animal blood oxygen saturation information is H average value of the animal heart rate information, B Average The average value of the motion conditions of the chest and the abdomen of the animal, D is the motion path distance of the animal, and W is the information of the duration of the animal not sleeping; wherein,
when the animal is a mouse, γ 1 Is 4, gamma 2 Is 4, gamma 3 Is 10, gamma 4 Is 8, gamma 5 Is 10, T 0 At 38.0 ℃ and S 0 99.5% of H 0 Is 650 times/min, W 0 Is 36 smallHour and D 0 10000 m, B 0 175 times/min;
when the animal is a rat, γ 1 Is 3, gamma 2 Is 4, gamma 3 Is 8, gamma 4 Is 9, gamma 5 Is 14, T 0 At 38.5 ℃ and S 0 99.5% of H 0 Is 360 times/min, W 0 36 hours, D 0 8000 m, B 0 130 times/min;
when the animal is guinea pig, γ 1 Is 5, gamma 2 Is 4, gamma 3 Is 5, gamma 4 Is 10, gamma 5 Is 16, T 0 At 38.2 ℃ and S 0 99.5% of H 0 220 times/min, W 0 36 hours, D 0 Is 5000 m, B 0 Is 105 times/min.
2. The animal sleep rhythm control test method as set forth in claim 1, wherein the animal sleep rhythm control test method further comprises, during controlling the operation of the sleep rhythm control test device according to the sleep rhythm control program:
acquiring animal image information;
identifying the animal image information and judging whether the animal goes to sleep or not; if so, then
Generating an electrical stimulation signal and transmitting the electrical stimulation signal to an electrical stimulation system.
3. The animal sleep rhythm control test method as set forth in claim 2, wherein the recognizing the animal image information and determining whether the animal is asleep comprises:
acquiring animal image information for multiple times at preset time intervals;
identifying whether the animals in the animal image information obtained at each time are all closed eyes, if yes, then
And judging that the animal enters the sleep.
4. The animal sleep rhythm control test method as set forth in claim 3, wherein the animal sleep rhythm control test method further comprises, during controlling the operation of the sleep rhythm control test device according to the sleep rhythm control program:
acquiring the oxygen content in the sleep rhythm regulation test device;
and when the oxygen content is lower than a preset threshold value, generating an oxygen supply signal and transmitting the oxygen supply signal to the sleep rhythm regulation and control test system to improve the oxygen content in the sleep rhythm regulation and control test device.
5. An animal sleep rhythm control test device, characterized in that, the animal sleep rhythm control test device includes:
the physiological information acquisition module is used for acquiring basic physiological information of the animal;
the scoring model acquisition module is used for acquiring a scoring model;
the scoring module is used for inputting the basic physiological information of the animal into the scoring model so as to obtain animal scoring;
a conditioning database acquisition module for acquiring a conditioning database, the conditioning database comprising at least one sleep rhythm conditioning regimen and at least one preset score, one sleep rhythm conditioning regimen being associated with at least one preset score;
the judgment module is used for judging whether the obtained animal score is the same as one preset score in all preset scores in the regulation database;
the execution module is used for acquiring the sleep rhythm regulation scheme under the condition that the judgment module judges that the sleep rhythm regulation scheme exists, and controlling the sleep rhythm regulation test device to work according to the sleep rhythm regulation scheme; wherein,
the basic physiological information of the animal comprises animal body temperature information, animal blood oxygen saturation information, animal heart rate information, animal sleep-free time length information, animal movement path and distance information and animal chest and abdomen movement information;
the sleep rhythm regulation scheme includes at least one or more of the following:
the first scheme is as follows: within 48 hours, the stimulation is carried out every 30 minutes at the intensity of 40w of illumination, each time lasts for 30 minutes, and the stimulation is carried out every 1 hour at the noise of 80-90 decibels, each time lasts for 5 minutes;
the second scheme is as follows: within 36 hours, the light 60w intensity stimulation is carried out every 20 minutes, each time lasts for 30 minutes, and the noise is 90-110 decibels every 1 hour and each time lasts for 2 minutes;
the third scheme is as follows: within 72 hours, the stimulation with the intensity of 50w of light is carried out every 10 minutes, each time lasts for 50 minutes, and the stimulation with the noise of 50-70 decibels is carried out every 1 hour, each time lasts for 10 minutes;
in the process of controlling the work of the sleep rhythm control test device according to the sleep rhythm control scheme, the animal sleep rhythm control test method further comprises the following steps:
acquiring animal image information;
identifying the animal image information and judging whether the animal goes to sleep or not; if so, then
Generating an electrical stimulation signal and transmitting the electrical stimulation signal to an electrical stimulation system;
the scoring model is as follows:
Σ Score =（W/36）+〔log 1.3 T 0 - log 1.3 （T average ）〕* γ 1 +〔log 0.65 （S Average out ）- log 0.65 S 0 〕* γ 2 + 〔log 4.5 H 0 - log 4.5 （H Average out ）〕* γ 3 +（log 2000 D 0 - log 2000 D）* γ 4 +〔lgB 0 -lg（B Average ）〕* γ 5 (ii) a Wherein,
the reference value of the animal body temperature information is T 0 The reference value of the blood oxygen saturation information of the animal is S 0 The animal heart rate information reference value is H 0 The reference value of the information of the length of time when the animal does not sleep is W 0 The reference value of the animal movement path distance information is D 0 The reference value of the chest and abdomen movement condition of the animal is B 0 ；T Average Is the mean value of body temperature、S Average The average value of the blood oxygen saturation information of the animal, the average value of the H average information of the heart rate of the animal, B Average out The average value of the chest and abdomen movement conditions of the animal, D the movement path distance of the animal and W the information of the non-sleeping time length of the animal are obtained; wherein,
when the animal is a mouse, γ 1 Is 4, gamma 2 Is 4, gamma 3 Is 10, gamma 4 Is 8, gamma 5 Is 10, T 0 At 38.0 ℃ and S 0 99.5% of H 0 Is 650 times/min, W 0 36 hours, D 0 10000 m, B 0 175 times/min;
when the animal is a rat, γ 1 Is 3, gamma 2 Is 4, gamma 3 Is 8, gamma 4 Is 9, gamma 5 Is 14, T 0 At 38.5 ℃ and S 0 99.5% of H 0 Is 360 times/min, W 0 36 hours, D 0 8000 m, B 0 130 times/min;
when the animal is a guinea pig, γ 1 Is 5, gamma 2 Is 4, gamma 3 Is 5, gamma 4 Is 10, gamma 5 Is 16, T 0 At 38.2 ℃ and S 0 99.5% of H 0 Is 220 times/min, W 0 36 hours, D 0 Is 5000 m, B 0 Is 105 times/min.
6. A sleep rhythm control test system, characterized in that the sleep rhythm control test system comprises:
the box comprises a closed box body, wherein an accommodating space is arranged in the closed box body;
the conductive plate is arranged in the accommodating space and is suitable for placing a test animal;
the power supply system is connected with the conductive plate and used for providing stimulation current for the conductive plate;
the animal basic information detection device is used for detecting basic physiological information of the animal;
the animal sleep rhythm control test device according to claim 5, wherein the animal sleep rhythm control test device is respectively connected with the power supply system, the oxygen supply device, the sound source, the oxygen detector, the temperature and humidity detection device, the illumination device and the camera device and is used for respectively providing working signals for each device connected with the animal sleep rhythm control test device;
one end of the oxygen supply pipe extends into the accommodating space;
the oxygen supply device is connected with the other end of the oxygen supply pipe and is used for supplying oxygen to the accommodating space through the oxygen supply pipe;
a microphone disposed within the accommodating space;
the sound source is connected with the loudspeaker;
the oxygen detector is arranged in the accommodating space and used for detecting the oxygen content in the accommodating space;
the temperature and humidity detection device is arranged in the accommodating space and is used for detecting the temperature and the humidity in the accommodating space;
an illumination device disposed within the accommodation space;
the number of the camera devices is multiple, and the camera devices are distributed in the accommodating space.
7. The sleep rhythm control test system as set forth in claim 6, wherein the animal basic information detecting means includes:
a heart rate monitoring device for detecting animal heart rate information of an animal;
the system comprises a blood oxygen saturation monitor, a data processing unit and a data processing unit, wherein the blood oxygen saturation monitor is used for detecting animal oxygen content information of animals.
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