CN113905670B - 引导式超声成像 - Google Patents

引导式超声成像

Info

Publication number
CN113905670B
CN113905670B CN202080040358.0A CN202080040358A CN113905670B CN 113905670 B CN113905670 B CN 113905670B CN 202080040358 A CN202080040358 A CN 202080040358A CN 113905670 B CN113905670 B CN 113905670B
Authority
CN
China
Prior art keywords
image
ultrasound
user
target
volumetric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080040358.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN113905670A (zh
Inventor
R·宗
E·M·坎菲尔德
G·J·哈里森
A·W·霍姆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of CN113905670A publication Critical patent/CN113905670A/zh
Application granted granted Critical
Publication of CN113905670B publication Critical patent/CN113905670B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/46Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
    • A61B8/467Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means
    • A61B8/469Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means for selection of a region of interest
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Clinical applications
    • A61B8/0833Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/085Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Clinical applications
    • A61B8/0866Clinical applications involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42Details of probe positioning or probe attachment to the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4488Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/483Diagnostic techniques involving the acquisition of a 3D volume of data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5207Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/523Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for generating planar views from image data in a user selectable plane not corresponding to the acquisition plane
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/11Region-based segmentation
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/70Determining position or orientation of objects or cameras
    • G06T7/73Determining position or orientation of objects or cameras using feature-based methods
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/70Determining position or orientation of objects or cameras
    • G06T7/73Determining position or orientation of objects or cameras using feature-based methods
    • G06T7/74Determining position or orientation of objects or cameras using feature-based methods involving reference images or patches
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/40ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/02Foetus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13Tomography
    • A61B8/14Echo-tomography
    • A61B8/145Echo-tomography characterised by scanning multiple planes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/58Testing, adjusting or calibrating the diagnostic device
    • A61B8/585Automatic set-up of the device
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10132Ultrasound image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10132Ultrasound image
    • G06T2207/101363D ultrasound image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30044Fetus; Embryo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Vascular Medicine (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN202080040358.0A 2019-05-31 2020-05-27 引导式超声成像 Active CN113905670B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962855453P 2019-05-31 2019-05-31
US62/855,453 2019-05-31
PCT/EP2020/064714 WO2020239842A1 (en) 2019-05-31 2020-05-27 Guided ultrasound imaging

Publications (2)

Publication Number Publication Date
CN113905670A CN113905670A (zh) 2022-01-07
CN113905670B true CN113905670B (zh) 2026-03-24

Family

ID=70861500

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080040358.0A Active CN113905670B (zh) 2019-05-31 2020-05-27 引导式超声成像

Country Status (5)

Country Link
US (1) US12048589B2 (https=)
EP (1) EP3975865B1 (https=)
JP (1) JP7442548B2 (https=)
CN (1) CN113905670B (https=)
WO (1) WO2020239842A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4037569B1 (en) * 2019-09-30 2025-03-19 Koninklijke Philips N.V. Recording ultrasound images
CN114727806A (zh) * 2019-11-21 2022-07-08 皇家飞利浦有限公司 照护点超声(pocus)扫描辅助和相关装置、系统和方法
US11523801B2 (en) * 2020-05-11 2022-12-13 EchoNous, Inc. Automatically identifying anatomical structures in medical images in a manner that is sensitive to the particular view in which each image is captured
EP4301268A4 (en) * 2021-03-05 2025-01-22 New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery RADIOLOGICALLY NAVISED INTRAOPERATIVE SPINE GUIDANCE SYSTEM
AU2022252500A1 (en) * 2021-04-02 2023-10-19 Anode IP LLC Systems and methods to process electronic medical images for diagnostic or interventional use
CN116831624A (zh) * 2022-03-25 2023-10-03 深圳迈瑞生物医疗电子股份有限公司 超声成像设备的控制方法、图像处理方法及其设备
EP4577119A1 (en) * 2022-08-23 2025-07-02 Koninklijke Philips N.V. Automated neural network selection for ultrasound
EP4331499A1 (en) * 2022-08-29 2024-03-06 Koninklijke Philips N.V. Ultrasound imaging systems and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2618294A1 (en) * 2005-08-09 2007-02-15 Koninklijke Philips Electronics, N.V. System and method for selective blending of 2d x-ray images and 3d ultrasound images
US8858436B2 (en) * 2008-11-12 2014-10-14 Sonosite, Inc. Systems and methods to identify interventional instruments
CN102365653B (zh) * 2009-03-27 2015-02-25 皇家飞利浦电子股份有限公司 对医学成像的改进
US8355554B2 (en) * 2009-04-14 2013-01-15 Sonosite, Inc. Systems and methods for adaptive volume imaging
JP5462598B2 (ja) * 2009-11-18 2014-04-02 日立アロカメディカル株式会社 超音波診断システム
US20110255762A1 (en) * 2010-04-15 2011-10-20 Harald Deischinger Method and system for determining a region of interest in ultrasound data
US8891881B2 (en) 2012-01-25 2014-11-18 General Electric Company System and method for identifying an optimal image frame for ultrasound imaging
DE102012204134B4 (de) * 2012-03-16 2021-02-11 Siemens Healthcare Gmbh Verfahren zum automatischen Bestimmen von Bildgebungs-Ebenen und Magnetresonanzanlage
IN2014MN02601A (https=) * 2012-06-04 2015-07-24 Tel Hashomer Medical Res Infrastructure & Services Ltd
EP3043863B1 (en) * 2013-09-11 2019-12-04 The Board of Trustees of the Leland Stanford Junior University Arrays of accelerating structures and rapid imaging for facilitating rapid radiation therapies
WO2015087218A1 (en) * 2013-12-09 2015-06-18 Koninklijke Philips N.V. Imaging view steering using model-based segmentation
WO2015170304A1 (en) * 2014-05-09 2015-11-12 Koninklijke Philips N.V. Imaging systems and methods for positioning a 3d ultrasound volume in a desired orientation
CN105433981B (zh) * 2015-12-07 2018-08-07 深圳开立生物医疗科技股份有限公司 一种超声成像方法、装置及其超声设备
EP3451932B1 (en) * 2016-05-06 2020-10-28 Koninklijke Philips N.V. Ultrasonic imaging system with simplified 3d imaging controls
US11712221B2 (en) * 2016-06-20 2023-08-01 Bfly Operations, Inc. Universal ultrasound device and related apparatus and methods
CN110087555B (zh) 2017-05-12 2022-10-25 深圳迈瑞生物医疗电子股份有限公司 一种超声设备及其三维超声图像的显示变换方法、系统
EP3435324A1 (en) * 2017-07-27 2019-01-30 Koninklijke Philips N.V. Fetal ultrasound image processing
KR102063294B1 (ko) * 2017-10-11 2020-01-07 알레시오 주식회사 초음파 영상을 실사 영상으로 변환하는 방법 및 그 장치
WO2019086365A1 (en) * 2017-11-02 2019-05-09 Koninklijke Philips N.V. Intelligent ultrasound system for detecting image artefacts
CN112105300B (zh) 2018-03-12 2024-09-27 皇家飞利浦有限公司 用于神经网络的超声成像平面对准指导及相关装置、系统和方法
CN112105301B (zh) 2018-03-12 2024-10-18 皇家飞利浦有限公司 使用神经网络的超声成像平面对准及相关装置、系统和方法
US11638569B2 (en) * 2018-06-08 2023-05-02 Rutgers, The State University Of New Jersey Computer vision systems and methods for real-time needle detection, enhancement and localization in ultrasound
EP3836843A4 (en) * 2018-08-13 2022-02-16 Rutgers, the State University of New Jersey ARTIFICIAL VISION SYSTEMS AND METHODS FOR REAL-TIME LOCATION OF NEEDLES IN ULTRASOUND IMAGES
EP3838163A1 (en) * 2019-12-17 2021-06-23 Koninklijke Philips N.V. Method and system for improved ultrasound plane acquisition

Also Published As

Publication number Publication date
JP2022534253A (ja) 2022-07-28
US20220211348A1 (en) 2022-07-07
JP7442548B2 (ja) 2024-03-04
WO2020239842A1 (en) 2020-12-03
US12048589B2 (en) 2024-07-30
EP3975865B1 (en) 2023-07-12
EP3975865A1 (en) 2022-04-06
CN113905670A (zh) 2022-01-07

Similar Documents

Publication Publication Date Title
CN113905670B (zh) 引导式超声成像
CN111432731B (zh) 用于检测图像伪影的智能超声系统
CN111200973B (zh) 基于智能超声的生育力监测
US11521363B2 (en) Ultrasonic device, and method and system for transforming display of three-dimensional ultrasonic image thereof
JP6629094B2 (ja) 超音波診断装置、医用画像処理装置及び医用画像処理プログラム
JP7605268B2 (ja) 超音波画像による脂肪層の識別
JP6097452B2 (ja) 超音波撮像システム及び超音波撮像方法
CN112603361A (zh) 用于在超声图像中跟踪解剖特征的系统和方法
US20200345325A1 (en) Automated path correction during multi-modal fusion targeted biopsy
EP2752818A2 (en) Method and apparatus for providing medical images
CN113795198B (zh) 用于控制体积速率的系统和方法
CN106659473A (zh) 超声成像装置
KR102419310B1 (ko) 초음파 이미징 데이터로부터 태아 이미지들을 프로세싱 및 디스플레이하기 위한 방법들 및 시스템들
JP2017514633A (ja) 3d超音波ボリュームを所望の方向に配置する撮像システム及び方法
CN118695814A (zh) 胎儿心率监测
US20210077344A1 (en) Ultrasound imaging with real-time visual feedback for cardiopulmonary resuscitation (cpr) compressions
JP6501796B2 (ja) 超音波画像のモデル・ベースのセグメンテーションのための取得方位依存特徴
EP4591803A1 (en) Method of improving quality of ultrasound image and ultrasound imaging apparatus therefor
US11382595B2 (en) Methods and systems for automated heart rate measurement for ultrasound motion modes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TG01 Patent term adjustment
TG01 Patent term adjustment

Free format text: NEW EXPIRY DATE: 20400918