CN113903487A - Automatic conveying and purifying process for medical isotope - Google Patents
Automatic conveying and purifying process for medical isotope Download PDFInfo
- Publication number
- CN113903487A CN113903487A CN202110961213.0A CN202110961213A CN113903487A CN 113903487 A CN113903487 A CN 113903487A CN 202110961213 A CN202110961213 A CN 202110961213A CN 113903487 A CN113903487 A CN 113903487A
- Authority
- CN
- China
- Prior art keywords
- hydrochloric acid
- purification process
- target
- dissolve
- medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 82
- 239000011521 glass Substances 0.000 claims abstract description 16
- 238000000746 purification Methods 0.000 claims abstract description 14
- 239000002184 metal Substances 0.000 claims abstract description 11
- 230000005540 biological transmission Effects 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 239000011347 resin Substances 0.000 claims abstract description 6
- 229920005989 resin Polymers 0.000 claims abstract description 6
- 239000013077 target material Substances 0.000 claims abstract description 6
- 238000004090 dissolution Methods 0.000 claims description 20
- 239000001307 helium Substances 0.000 claims description 5
- 229910052734 helium Inorganic materials 0.000 claims description 5
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 5
- 239000000956 alloy Substances 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000009616 inductively coupled plasma Methods 0.000 description 3
- 239000003456 ion exchange resin Substances 0.000 description 3
- 229920003303 ion-exchange polymer Polymers 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention relates to a medical isotope automatic transmission purification process, S1, irradiating a 64Ni target to obtain a target containing 64 Cu; s2, moving the metal in the step S1 from the reaction area to a glass dissolving area through a mechanical arm to chemically dissolve the target material; s3, adding 9M hydrochloric acid into a glass dissolving area through an automatic pump to dissolve, wherein the usage amount of the hydrochloric acid is 4 milliliters; s4, controlling the temperature to 90 ℃ through a temperature controller to dissolve for 20 minutes; s5, stopping the temperature controller, starting compressed air connected with the reactor, and cooling to normal temperature; s6, hydrochloric acid for dissolving 64Cu and 64Ni, and automatically conveying the solution to a 20X 0.8 cm resin column through a pipeline; s7, 64Ni was completely expelled with 45mL of 6M hydrochloric acid, after which the remaining 64Cu was collected by using 20mL of 0.1N hydrochloric acid. The invention can be used for64And (4) carrying out automatic purification on Cu.
Description
Technical Field
The invention relates to a purification process, in particular to an automatic transmission purification process for medical isotopes.
Background
Cu is the third most abundant metal in normal human body, and the content is 1.7 +/-0.4 mg/kg. Poor regulation of Cu in vivo can lead to a range of regulatory diseases. Analysis of the physical decay rate of Cu radionuclides can explore fast-uptake perfusion properties of the myocardium and kidney, slow-accumulation properties of Cu agents, and the course of larger molecules for specific receptors or other targets on the cell surface. Thus, it is possible to provide64The need for Cu radioisotope diagnostics and the application of radioisotope therapy is expanding in society.64The Cu isotope automatic transmission process technology has great importance for developing production practice, quality assurance and supervision level. Due to the large number of applications64The dose rates involved with Cu, large scale applications must be produced using an automated purification process. To reduce impurities and reduce64Volume of Cu fraction, should be collected64The Cu fraction is at the end of the column. At the end of the purification step or steps,64the Cu fractions should be sequentially evaporated to reduce high concentration hydrochloric acid and collected at minimum volume64And (3) Cu. The gas used in this step is also a potential source of metal contamination and therefore it should be as pure as possible.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide an automatic conveying and purifying process for medical isotopes.
The technical scheme of the invention is as follows:
an automatic transmission purification process for medical isotopes is characterized in that:
s1, irradiating the 64Ni target to obtain a target containing 64 Cu;
s2, moving the metal in the step S1 from the reaction area to a glass dissolving area through a mechanical arm to chemically dissolve the target material;
s3, adding 9M hydrochloric acid into a glass dissolving area through an automatic pump to dissolve, wherein the usage amount of the hydrochloric acid is 4 milliliters;
s4, controlling the temperature to 90 ℃ through a temperature controller to dissolve for 20 minutes;
s5, stopping the temperature controller, starting compressed air connected with the reactor, and cooling to normal temperature;
s6, hydrochloric acid for dissolving 64Cu and 64Ni, and automatically conveying the solution to a 20X 0.8 cm resin column through a pipeline;
s7, 64Ni was completely expelled with 45mL of 6M hydrochloric acid, after which the remaining 64Cu was collected by using 20mL of 0.1N hydrochloric acid.
Further, the step S1 is specifically generated by bombarding the concentrated 64Ni sample target with a high-energy proton beam at a geometric 6 degree incident angle.
Further, the energy of the high-energy proton is 9-20 MeV.
Furthermore, the proton beam current is 20-200 muA, and the irradiation time is 2-5 hours.
Further, the flow rate of the hydrochloric acid in the step 6 is 1 mL/min.
Further, the flow rate of the hydrochloric acid in the step 7 is 1 mL/min.
Further, in step S4, the glass dissolution zone is always connected to helium.
By the scheme, the invention at least has the following advantages:
the invention can promote the diagnosis and treatment of radioactive isotope, and is greatly helpful for early diagnosis, screening method and novel treatment method. In particular, the process of tracking and measuring the rapid uptake perfusion characteristics of the myocardium and kidney, the slow accumulation of Cu, and larger molecules (antibodies) to specific receptors or other targets on the cell surface.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a detailed description of the preferred embodiments of the present invention.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
64Cu can be obtained by using64Ni(p，n)64Nuclear reaction of Cu, specifically using high energy proton (9MeV) beam directed at a geometrical 6 degree angle of incidence64The Ni sample is generated by target bombing. Proton beam current an/M at 20-200 μ A and irradiation time 2 hours.
In our optimized experiment, we target Ni samples on a solid target system on a cyclone 30 accelerator and irradiate with high energy protons at 15.6 MeV. The incident angle of the irradiation was 6 degrees,64the normal production run for Cu was carried out with a proton current of 30 μ Α for 2 hours.
64After the Ni is irradiated,64target metal of NiThe robotic arm moves from the reaction zone to the glass dissolution zone to effect chemical dissolution of the target material. The 9M hydrochloric acid was added by an automatic pump to the glass dissolution zone to dissolve in an amount of 4 ml. The temperature controller controls the temperature to 90 ℃ for dissolution, and meanwhile, the glass dissolution area is always connected with helium gas, and the dissolution is completed within 20 minutes. The temperature controller was stopped and the compressed air connected to the reactor was turned on and cooling was carried out for 12 minutes. Then, dissolve64Cu and64the hydrochloric acid of Ni (flow rate 1mL/min) was automatically transferred through a tube to a 20X 0.8 cm resin column, inside which ion exchange resins AG 1-X8(5g, Cl-form) were placed.64Ni was completely expelled at a flow rate of 1mL/min with 45mL of 6M hydrochloric acid, the first 20mL of 6N hydrochloric acid being used for collection64Ni for recovery, the remaining 25 ml of hydrochloric acid for collecting Co metal, which is then retained64Cu was collected by using 20mL of 0.1N hydrochloric acid.64The Cu was recovered in approximately 3mL of hydrochloric acid and all liquid was collected with a tube autosampler. And (4) analyzing and characterizing the liquid coming out at different times by an inductively coupled plasma mass spectrometer.
Example 2
64Cu can be obtained by using64Ni(p，n)64Nuclear reaction of Cu, specifically using high energy proton (9-20MeV) beam to concentrate in a geometrical 6 degree incident angle direction64The Ni sample is generated by target bombing. Proton beam current a/m was at 100 μ A and irradiation time was 3 hours.
In our optimized experiment, we target Ni samples on a solid target system on a cyclone 30 accelerator and irradiate with high energy protons at 15.6 MeV. The incident angle of the irradiation was 6 degrees,64the normal production run for Cu was carried out with a proton current of 40 μ Α for 2.5 hours.
64After the Ni is irradiated,64the Ni target metal is moved from the reaction zone to the glass dissolution zone by a robot arm to perform chemical dissolution of the target material. The 9M hydrochloric acid was added by an automatic pump to the glass dissolution zone to dissolve in an amount of 4 ml. The temperature controller controls the temperature to 90 ℃ for dissolution, and simultaneously the glassThe dissolution zone was always connected to helium and dissolution was complete within 20 minutes. The temperature controller was stopped and the compressed air connected to the reactor was turned on and cooling was carried out for 12 minutes. Then, dissolve64Cu and64the hydrochloric acid of Ni (flow rate 1mL/min) was automatically transferred through a tube to a 20X 0.8 cm resin column, inside which ion exchange resins AG 1-X8(5g, Cl-form) were placed.64Ni was completely expelled at a flow rate of 1mL/min with 45mL of 6M hydrochloric acid, the first 20mL of 6N hydrochloric acid being used for collection64Ni for recovery, the remaining 25 ml of hydrochloric acid for collecting Co metal, which is then retained64Cu was collected by using 20mL of 0.1N hydrochloric acid.64The Cu was recovered in approximately 3mL of hydrochloric acid and all liquid was collected with a tube autosampler. And (4) analyzing and characterizing the liquid coming out at different times by an inductively coupled plasma mass spectrometer.
Example 3
64Cu can be obtained by using64Ni(p，n)64Nuclear reaction of Cu, specifically using high energy proton (9-20MeV) beam to concentrate in a geometrical 6 degree incident angle direction64The Ni sample is generated by target bombing. Proton beam current a/m was at 200 μ A and irradiation time was 5 hours.
In our optimized experiment, we target Ni samples on a solid target system on a cyclone 30 accelerator and irradiate with high energy protons at 15.6 MeV. The incident angle of the irradiation was 6 degrees,64the normal production run for Cu was carried out with a proton current of 70 μ Α for 3 hours.
64After the Ni is irradiated,64the Ni target metal is moved from the reaction zone to the glass dissolution zone by a robot arm to perform chemical dissolution of the target material. The 9M hydrochloric acid was added by an automatic pump to the glass dissolution zone to dissolve in an amount of 4 ml. The temperature controller controls the temperature to 90 ℃ for dissolution, and meanwhile, the glass dissolution area is always connected with helium gas, and the dissolution is completed within 20 minutes. The temperature controller was stopped and the compressed air connected to the reactor was turned on and cooling was carried out for 12 minutes. Thereafter, hydrochloric acid (flow rate 1mL/min) dissolving 64Cu and 64Ni was automatically transferred through a pipeA20X 0.8 cm column of resin was placed inside ion exchange resin AG 1-X8(5g, Cl-form). 64Ni was completely removed at a flow rate of 1mL/min with 45mL of 6M hydrochloric acid, the first 20mL of 6N hydrochloric acid was used to collect 64Ni for recovery, the remaining 25 mL of hydrochloric acid was used to collect Co metal, and the remaining 64Cu was collected by using 20mL of 0.1N hydrochloric acid. 64Cu was recovered in approximately 3mL of hydrochloric acid and all liquid was collected with a tube autosampler. And (4) analyzing and characterizing the liquid coming out at different times by an inductively coupled plasma mass spectrometer.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (7)
1. An automatic transmission purification process for medical isotopes is characterized in that:
s1, mixing64Irradiating the Ni target to obtain Ni-containing alloy64A target of Cu;
s2, moving the metal in the step S1 from the reaction area to a glass dissolving area through a mechanical arm to chemically dissolve the target material;
s3, adding 9M hydrochloric acid into a glass dissolving area through an automatic pump to dissolve, wherein the usage amount of the hydrochloric acid is 4 milliliters;
s4, controlling the temperature to 90 ℃ through a temperature controller to dissolve for 20 minutes;
s5, stopping the temperature controller, starting compressed air connected with the reactor, and cooling to normal temperature;
s6, dissolving64Cu and64hydrochloric acid of Ni is automatically transmitted to a resin column of 20 multiplied by 0.8 cm through a pipeline;
S7、64ni was completely expelled in 45mL of 6M hydrochloric acid and remained64Cu was collected by using 20mL of 0.1N hydrochloric acid.
2. According to the claimsThe automatic transmission and purification process of the medical isotope in the claim 1 is characterized in that: the step S1 is specifically performed by using the high-energy proton beam to irradiate the concentrated solution at a geometric incident angle of 6 degrees64The Ni sample is generated by target bombing.
3. The automated transportation and purification process of medical isotopes according to claim 2, wherein: the high-energy proton energy is 9-20 MeV.
4. The automated transportation and purification process of medical isotopes according to claim 2, wherein: the proton beam current is 20-200 muA, and the irradiation time is 2-5 hours.
5. The automated transportation and purification process of medical isotopes according to claim 1, wherein: the flow rate of the hydrochloric acid in the step 6 is 1 mL/min.
6. The automated transportation and purification process of medical isotopes according to claim 1, wherein: the flow rate of the hydrochloric acid in the step 7 is 1 mL/min.
7. The automated transportation and purification process of medical isotopes according to claim 1, wherein: in the step S4, the glass dissolution zone is always connected with helium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110961213.0A CN113903487A (en) | 2021-08-20 | 2021-08-20 | Automatic conveying and purifying process for medical isotope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110961213.0A CN113903487A (en) | 2021-08-20 | 2021-08-20 | Automatic conveying and purifying process for medical isotope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113903487A true CN113903487A (en) | 2022-01-07 |
Family
ID=79187701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110961213.0A Pending CN113903487A (en) | 2021-08-20 | 2021-08-20 | Automatic conveying and purifying process for medical isotope |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113903487A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115432730A (en) * | 2022-11-09 | 2022-12-06 | 南京硼高生物科技有限公司 | Carrier-free medical isotope Cu-64 purification method and automatic purification process |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011825A (en) * | 1995-08-09 | 2000-01-04 | Washington University | Production of 64 Cu and other radionuclides using a charged-particle accelerator |
| CN112567478A (en) * | 2018-08-02 | 2021-03-26 | Lenr西提斯瑞士有限责任公司 | Method and system for generating radioisotopes for medical applications |
-
2021
- 2021-08-20 CN CN202110961213.0A patent/CN113903487A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011825A (en) * | 1995-08-09 | 2000-01-04 | Washington University | Production of 64 Cu and other radionuclides using a charged-particle accelerator |
| CN112567478A (en) * | 2018-08-02 | 2021-03-26 | Lenr西提斯瑞士有限责任公司 | Method and system for generating radioisotopes for medical applications |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115432730A (en) * | 2022-11-09 | 2022-12-06 | 南京硼高生物科技有限公司 | Carrier-free medical isotope Cu-64 purification method and automatic purification process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111485123B (en) | Separation from large-amount and low-specific-activity Mo solution99mTc device and method | |
| RU2745524C2 (en) | Method of production of fraction of iodine radioisotopes, particularly i-131 | |
| JP7312621B2 (en) | Radionuclide production method and radionuclide production system | |
| TWI397421B (en) | Gallium-68 radioisotope generator and generating method thereof | |
| CN111465577A (en) | Method for producing astatine | |
| CN106898406B (en) | A kind of preparation method of radioactivity iodine-125 and continuous circulation loop device | |
| CN113903487A (en) | Automatic conveying and purifying process for medical isotope | |
| Shusterman et al. | Aqueous harvesting of Zr 88 at a radioactive-ion-beam facility for cross-section measurements | |
| Jeffery et al. | Routine production of copper-64 using 11.7 MeV protons | |
| AU2019399674A1 (en) | Processes and systems for producing and/or purifying gallium-68 | |
| Katabuchi et al. | Production of 67 Cu via the 68 Zn (p, 2p) 67 Cu reaction and recovery of 68 Zn target | |
| RU2624636C1 (en) | Method of obtaining a radionuclide of lutetium-177 | |
| US9695507B2 (en) | Automatic lithium target regenerating apparatus and automatic lithium target regenerating method | |
| JPS58215600A (en) | Method of making radioactive iodine-123 | |
| US8647595B2 (en) | Method for separating radioactive copper using chelating-ion exchange resin | |
| CN109437343B (en) | Preparation method of sodium pertechnetate solution | |
| KR101041181B1 (en) | Method of separating Cu-64 from the enriched Ni-64 target in which Cu-64 is produced, to prepare Cu-64 | |
| CN112973445B (en) | Automatic processing device for separating Ac-225 and operation method thereof | |
| Vandegrift et al. | RERTR progress in Mo-99 production from LEU | |
| CN211864500U (en) | Extraction from dissolved irradiated uranium target tail gas131I apparatus | |
| CN113877421A (en) | Medical isotope separation and purification process | |
| KR101171029B1 (en) | Device for Separation of Radiocarbon and Separation Method of Radiocarbon Using Thereof | |
| Kalniņa et al. | CHEMICAL SEPARATION AND PURIFICATION OF STABLE 45SC FROM CERN-MEDICIS MASS-SEPARATOR COLLECTION FOILS | |
| Damasceno et al. | Study of new routes for purification of fission 99Mo | |
| RU2430441C1 (en) | Bismuth-213 radionuclide obtaining method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |