CN113874512A - 诱导毛细胞分化的组合物和方法 - Google Patents

诱导毛细胞分化的组合物和方法 Download PDF

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CN113874512A
CN113874512A CN201980087541.3A CN201980087541A CN113874512A CN 113874512 A CN113874512 A CN 113874512A CN 201980087541 A CN201980087541 A CN 201980087541A CN 113874512 A CN113874512 A CN 113874512A
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amino acids
nucleotides
amino acid
acid substitutions
amino
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E.J.西蒙斯
R.恩格
D.伦兹
M.瓦莱罗
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Akus Co ltd
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Akus Co ltd
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CN201980087541.3A 2018-11-07 2019-11-07 诱导毛细胞分化的组合物和方法 Pending CN113874512A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862756910P 2018-11-07 2018-11-07
US62/756,910 2018-11-07
US201962888105P 2019-08-16 2019-08-16
US62/888,105 2019-08-16
PCT/US2019/060324 WO2020097369A1 (en) 2018-11-07 2019-11-07 Compositions and methods of inducing differentiation of a hair cell

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CN113874512A true CN113874512A (zh) 2021-12-31

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US (1) US20220395582A1 (https=)
EP (1) EP3880827A4 (https=)
JP (1) JP2022512921A (https=)
CN (1) CN113874512A (https=)
AU (1) AU2019376084A1 (https=)
CA (1) CA3119059A1 (https=)
WO (1) WO2020097369A1 (https=)

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WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
KR20230061333A (ko) * 2020-06-23 2023-05-08 칠드런즈 호스피탈 메디칼 센터 인슐린 저항성 모델
JP2024517843A (ja) * 2021-05-05 2024-04-23 デシベル セラピューティクス インコーポレイテッド ステレオシリン二重ベクター系を使用して感音性難聴を治療するための組成物及び方法
JP2025503508A (ja) * 2021-12-23 2025-02-04 ユニバーシティ オブ ロチェスター 内耳への薬剤の送達のための組成物及び方法
WO2025094056A1 (en) * 2023-10-31 2025-05-08 Children's Medical Research Institute Gene therapy constructs and methods of use therefor

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US20040166091A1 (en) * 2003-02-24 2004-08-26 Genvec, Inc. Materials and methods for treating disorders of the ear
WO2017100791A1 (en) * 2015-12-11 2017-06-15 Massachusetts Eye And Ear Infirmary Materials and methods for delivering nucleic acids to cochlear and vestibular cells

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CA2801535C (en) * 2010-06-04 2017-05-30 Hough Ear Institute Composition and method for inner ear sensory hair cell regeneration or replacement
KR20140047141A (ko) * 2011-08-03 2014-04-21 쿠아크 파마수티칼스 인코퍼레이티드 청력 및 균형 장애를 치료하기 위한 이중-가닥 올리고뉴클레오티드 화합물들
CA2909733C (en) * 2013-04-18 2023-10-17 Fondazione Telethon Effective delivery of large genes by dual aav vectors
JP2015534818A (ja) * 2013-11-04 2015-12-07 ジェネシス リサーチ インスティチュート 聴覚を治療するための組成物および方法
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US20040166091A1 (en) * 2003-02-24 2004-08-26 Genvec, Inc. Materials and methods for treating disorders of the ear
WO2017100791A1 (en) * 2015-12-11 2017-06-15 Massachusetts Eye And Ear Infirmary Materials and methods for delivering nucleic acids to cochlear and vestibular cells

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AU2019376084A1 (en) 2021-05-20
JP2022512921A (ja) 2022-02-07
EP3880827A1 (en) 2021-09-22
EP3880827A4 (en) 2023-04-26
CA3119059A1 (en) 2020-05-14
WO2020097369A1 (en) 2020-05-14
US20220395582A1 (en) 2022-12-15

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