CN113867006B - Gamma-Fe-based 2 O 3 Flexible multifunctional cornea contact lens of@NiO magnetic oxide nanosheets - Google Patents
Gamma-Fe-based 2 O 3 Flexible multifunctional cornea contact lens of@NiO magnetic oxide nanosheets Download PDFInfo
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- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
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Abstract
The invention provides a gamma-Fe-based alloy 2 O 3 Flexible multifunctional cornea contact lens of NiO magnetic oxide nano-sheet belongs to biomedical equipment technical field. The contact lens core structure adopts gamma-Fe2O3@NiO magnetic oxide nanosheet material, and three biological signals of nystagmus, intraocular pressure and glucose signals are detected simultaneously by combining the material with an electrochemical signal acquisition system, an external metal coil and different components of a Tesla meter, namely, detection of different physiological signals is realized by only one sensor; meanwhile, the device has high sensitivity, outstanding reliability and stability, can perform real-time detection, has a simple structure and low price, and is easy for mass production.
Description
Technical Field
The invention belongs to the technical field of biomedical appliances, and in particular relates to a gamma-Fe-based medical instrument 2 O 3 Flexible multifunctional cornea contact lens of NiO magnetic oxide nano-sheet.
Background
In the past, the world health organization issued the first world vision report indicating that aging of the population, changes in lifestyle, and acquisition of an ophthalmic care machine would be limited to the growing number of people with global vision impairment. It has been reported that at least 22 hundred million people worldwide are visually impaired or blind, with most people's vision impairment problems being primarily affected by diabetic retinopathy and glaucomaEffects of irreversible chronic diseases such as nystagmus. Some patients with these diseases have no obvious symptoms in the early stage, are difficult to find in time only by periodic regular physical examination, and when clinical symptoms occur, many irreversible vision impairment already occurs. Therefore, long-term monitoring of physiological signals such as blood glucose, ocular tension, eye movement, etc. is an effective approach to effectively control and treat diabetic retinopathy, glaucoma and nystagmus. Among the numerous physiological signals, glucose is particularly important for the diagnosis of diabetes. In clinic, natural peroxidases are commonly used for blood glucose testing, however, natural enzymes are not easy to prepare and store, resulting in high cost and low durability of glucose testing. Yan et al have demonstrated inorganic Fe 3 O 4 The magnetic nanoparticles have an intrinsic enzyme mimetic activity similar to that of the native peroxidase, which provides a possibility for an efficient enzyme-free glucose sensor (L.Gao, J.Zhuang, L.Nie, et al, intrin sic peroxidase-like activity of ferromagnetic nanoparticles [ J)].Nature Nanotechnology 2007,2 (9),577-583)。
The flexible wearable electronic device has larger mechanical flexibility, overcomes the hard brittleness of the traditional inorganic integrated device, and becomes the development direction of future electronic products. In recent years, researchers combine flexible cornea contact lenses with intelligent medical systems as a minimally invasive diagnostic platform to acquire physiological information of patients in real time, and play an important role in personal medical care and disease monitoring applications. In 2014, google and Novartis developed an intelligent contact lens, which detects glucose concentration in tear fluid by adding a micro electrochemical sensor into hydrogel material, and realizes wireless transmission through external equipment, thus providing a noninvasive blood glucose monitoring platform for diabetics and correcting eyesight of presbyopic patients. Thereafter, a variety of functional materials (e.g., graphene) are integrated onto wearable contact lenses for wireless detection of glucose and intraocular pressure, etc. ((1) M.Sen ior. Novartis signs up for Google smart lens [ J ]. Nature Biotechnology,2014,32 (9): 856-856; (2) J.Kim, M.Kim, M.Lee, et al, wearable smart sensor systems integrated on soft conta ct lenses for wireless ocular diagnostics [ J ]. Nature Communications,2017,8,14997; (3) K. Choi, H.g G.park. Smart Reinvention of the Contact Lens with Graphene [ J ]. ACS Nano 20, 17,11 (6), 5223-5226). The novel flexible intelligent cornea contact lens can be adhered to an eyeball in a conformal and seamless way, accurately monitors physiological signals such as glucose, intraocular pressure and the like in tears, and is favorable for intervention treatment before disease deterioration.
However, at present, most of cornea contact lenses can only detect specific biomarkers, and different eye health signals need to be detected by integrating a plurality of functional units, so that the problems of high flexibility difficulty, complex process, high cost and the like are caused. Therefore, developing a multifunctional sensor to realize multiple health signal detection has important significance for eye disease monitoring.
Disclosure of Invention
In view of the problems of the prior art, an object of the present invention is to provide a gamma-Fe-based alloy 2 O 3 Flexible multifunctional cornea contact lens of NiO magnetic oxide nano-sheet. The cornea contact lens adopts gamma-Fe innovatively 2 O 3 The nanometer NiO magnetic oxide sheet is used as a detection functional material, so that the simultaneous monitoring of three physiological signals of glucose, intraocular pressure and nystagmus is realized, the problems faced by the traditional multifunctional cornea contact lens are effectively solved, and the therapeutic device has the advantages of excellent stability, low price, simple preparation process and easy large-scale industrialized production.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
Gamma-Fe-based 2 O 3 Flexible multifunctional cornea contact lens of the NiO magnetic oxide nano-sheet comprises an external data acquisition and processing system (1-1) and an internal multifunctional cornea contact lens (1-2);
the inner multifunctional cornea contact lens (1-2) comprises an outer packaging film (1-3) and gamma-Fe 2 O 3 The device comprises an @ NiO magnetic oxide nanosheet sensing layer (1-5), a reference electrode (1-4), a counter electrode (1-6), an electrochemical signal acquisition system (1-7) and an inner packaging film (1-8); wherein, reference electrode (1-4), gamma-Fe 2 O 3 The @ NiO magnetic oxide nano-sheet sensor (1-5) and the counter electrode (1-6) are respectively connected with the electricity through metal wiresThe chemical signal acquisition systems (1-7) are connected;
the reference electrode (1-4), gamma-Fe 2 O 3 The system comprises a three-electrode system formed by an NiO magnetic oxide nano-sheet sensing layer (1-5) and a counter electrode (1-6), and is used for detecting an electrochemical signal and transmitting the signal to an electrochemical signal acquisition system (1-7); the electrochemical signal acquisition system (1-7) translates and interprets the electric signals generated by the three-electrode system and then outputs glucose signals;
the external data acquisition and processing system (1-1) comprises a lens frame, a metal coil (1-9) and a tesla meter (1-10); the Tesla gauge (1-10) and the metal coil (1-9) are arranged on the glasses frame;
the metal coils (1-9) and gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet sensing layer (1-5) forms an intraocular pressure data acquisition system, so that the detection of an eye pressure signal is realized; said teslameter (1-10) and gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer (1-5) forms an nystagmus data acquisition system for realizing nystagmus signal detection.
Further, the inner layer packaging film (1-8) is provided with a micro-channel, and tear fluid passes through the inner layer packaging film (1-8) and the reference electrode (1-4), the counter electrode (1-6) and gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layers (1-5) are in contact.
Furthermore, the number of the tesla meters (1-10) is preferably 4, and the tesla meters are arranged in four symmetrical directions of the metal coils (1-9).
Further, the gamma-Fe 2 O 3 The @ NiO magnetic oxide nanoplatelet sensing layer (1-5) is preferably of a spiral structure.
Further, the gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer is formed by cutting gamma-Fe by laser 2 O 3 The nano-sheet array of the NiO magnetic oxide is in a spiral structure.
Further, in the bending deformation range, the gamma-Fe 2 O 3 The smaller the line width of the spiral structure of the nano-sheet sensing layer of the@NiO magnetic oxide is, the more the number of spiral turns of the same area is, the more the number of turns is, and the detection precision is improvedThe higher the degree; the line width is preferably 300 μm, and the number of turns of the spiral is preferably 3 to 5.
Further, the reference electrode and the counter electrode are Ag/AgCl slurry and Pt wires respectively, and the arc length is 1.2mm.
Further, the metal coil is made of aluminum, silver or copper, and the line width is 10 mu m-2 mm.
Further, the materials of the outer packaging film and the inner packaging film are polymer solidified materials with Young's modulus of 10 kPa-100 MPa, specifically Ecoflex (aliphatic aromatic silicon-free copolyester); the thickness of the packaging film is 50-60 mu m.
The mechanism of the invention is as follows: reference electrode (1-4), gamma-Fe 2 O 3 The three-electrode system consisting of the nano-sheet sensing layer (1-5) of NiO magnetic oxide and the counter electrode (1-6) consists of two loops, wherein one loop consists of the reference electrode (1-4) and gamma-Fe 2 O 3 Composition of nano-sheet sensing layer (1-5) of magnetic oxide of @ Ni O for testing gamma-Fe 2 O 3 The electrochemical reaction process of the sensing layer (1-5) of the NiO magnetic oxide nano sheet has the advantages that the magnetic metal oxide nano sheet structure has larger specific surface area and rich active sites; another loop is formed by gamma-Fe 2 O 3 The nano-sheet sensing layer (1-5) of the NiO magnetic oxide consists of a counter electrode (1-6) and plays a role in transferring electrons to form a loop; the electrochemical signal acquisition system (1-7) is used for gamma-Fe 2 O 3 After translating and interpreting the electric signals generated by the@NiO magnetic oxide nanosheet sensing layer, outputting glucose signals. External metallic coil (1-9) of external intraocular pressure data acquisition system and internal gamma-Fe with spiral structure 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer (1-5) is based on an electromagnetic mutual coupling system, the spiral functional unit deforms along with intraocular pressure fluctuation, coupling mutual inductance between the spiral structure and the lens frame antenna is affected, and the characteristic frequency point of the antenna moves in a linear rule, so that an intraocular pressure signal is dynamically reflected. External nystagmus data acquisition system based on magnetic intensity test, tesla gauge (1-10) integrated in glasses frame for gamma-Fe 2 O 3 Magnetic induction intensity of the@NiO magnetic oxide nano sheet has position difference, namely, according to magnetism of magnetic materials at different positionsThe difference in intensity is sensed, thereby reflecting the nystagmus signal in real time.
In summary, due to the adoption of the technical scheme, the beneficial effects of the invention are as follows:
1. the sensor with the core structure adopts gamma-Fe2O3@NiO magnetic oxide nanosheet material, and three biological signals of nystagmus, intraocular pressure and glucose signals are detected simultaneously through the combination of the material and different components, namely, the detection of different physiological signals is realized through only one sensor; meanwhile, the device has high sensitivity, outstanding reliability and stability, can perform real-time detection, has a simple structure and low price, and is easy for mass production.
2. The invention provides a gamma-Fe-based alloy 2 O 3 The multifunctional cornea contact lens of the@NiO magnetic oxide nanosheet is simple to operate, namely the multifunctional cornea contact lens is placed on an eyeball, and the external data acquisition and processing system is worn, so that real-time detection can be completed, and a subject can conveniently and automatically detect in daily life.
Drawings
FIG. 1 is a schematic diagram of the construction of a multi-functional contact lens apparatus of the present invention;
the device comprises an external data acquisition and processing system (1-1), an internal multifunctional cornea contact lens (1-2), an external packaging film (1-3), a reference electrode (1-4), a magnetic oxide nano-sheet sensing layer (1-5), a counter electrode (1-6), an electrochemical signal acquisition system (1-7), an internal micro-channel packaging film (1-8), an external metal coil (1-9) and four tesla meters (1-10).
FIG. 2 shows the gamma-Fe-based alloy of the present invention 2 O 3 Multifunctional cornea contact lens physical image of NiO magnetic oxide nano-sheet.
FIG. 3 shows gamma-Fe of the present invention 2 O 3 X-ray diffraction pattern of NiO magnetic oxide nanoplatelets.
FIG. 4 shows gamma-Fe of the present invention 2 O 3 Scanning electron microscopy of NiO magnetic oxide nanoplatelets.
FIG. 5 shows a gamma-Fe-based alloy according to example 1 of the present invention 2 O 3 Glucose of@NiO magnetic oxide nanosheetsTesting an experimental chart;
wherein, (a) is a linear scan voltammogram, (b) is a current-time graph, (c) is a linear curve of concentration (0.005-0.5 mM) and current density, (d) is a linear curve of concentration (1.0-6.0 mM) and current density, (e) is an interferent test chart, and (f) is a reproducibility test chart.
FIG. 6 shows a gamma-Fe-based alloy according to example 1 of the present invention 2 O 3 Nystagmus experimental plot of NiO magnetic oxide nanoplatelets;
wherein, (a) is an eyeball movement model and a magnetic intensity distribution system, (b) is a repeatability test chart, and (c) is a real-time movement track tracking chart.
FIG. 7 shows a gamma-Fe-based alloy according to example 1 of the present invention 2 O 3 Experimental graph of intraocular pressure of NiO magnetic oxide nanoplatelets;
wherein, (a) is a resonance frequency chart, (b) is a resonance frequency chart under different eye pressures, and (c) is a linear relation chart of resonance frequency and intraocular pressure.
FIG. 8 is a confocal microscope image of the inner layer microchannel packaging film (1-8) of the multifunctional contact lens of the invention;
wherein (8-1) is a tear inlet, (8-2) is a tear outlet, (8-3) is a reference electrode, (8-4) is a counter electrode, and (8-5) is a magnetic oxide nanosheet sensing layer.
Detailed Description
The present invention will be described in further detail with reference to the embodiments and the accompanying drawings, for the purpose of making the objects, technical solutions and advantages of the present invention more apparent.
Gamma-Fe-based 2 O 3 Flexible multifunctional cornea contact lens of NiO magnetic oxide nano-sheet, whose structure is shown in fig. 1, comprises external data acquisition and processing system (1-1) and internal multifunctional cornea contact lens (1-2);
the internal multifunctional cornea contact lens comprises an outer packaging film (1-3), a reference electrode (1-4) and gamma-Fe 2 O 3 The device comprises an @ NiO magnetic oxide nanosheet sensing layer (1-5), a counter electrode (1-6), an electrochemical signal acquisition system (1-7) and an inner layer micro-channel packaging film (1-8); wherein, reference electrode (1-4), gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet sensor (1-5) and the counter electrode (1-6) are respectively connected with the electrochemical signal acquisition system (1-7) through metal wires;
the reference electrode (1-4), gamma-Fe 2 O 3 The system comprises a three-electrode system formed by an NiO magnetic oxide nano-sheet sensing layer (1-5) and a counter electrode (1-6), and is used for detecting an electrochemical signal and transmitting the signal to an electrochemical signal acquisition system (1-7); the electrochemical signal acquisition system (1-7) translates and interprets the electric signals generated by the three-electrode system and then outputs glucose signals;
the external data acquisition and processing system (1-1) comprises a lens frame, a metal coil (1-9) and a tesla meter (1-10); the Tesla gauge (1-10) and the metal coil (1-9) are arranged on the glasses frame;
the metal coils (1-9) and gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet sensing layer (1-5) forms an intraocular pressure data acquisition system, so that the detection of an eye pressure signal is realized; said teslameter (1-10) and gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensor (1-5) forms an nystagmus data acquisition system for realizing nystagmus signal detection.
Example 1
Gamma-Fe-based 2 O 3 The preparation method of the flexible multifunctional cornea contact lens of the NiO magnetic oxide nano sheet comprises the following steps:
0.1mol Fe (NO) was added to 30mL deionized water 3 ) 3 ·9H 2 O、0.1mol Ni(NO 3 ) 3 ·9H 2 O and 1mm ol CH 4 N 2 O, uniformly stirring, transferring into a 50mL autoclave, simultaneously placing pretreated foam nickel (2 x 3 cm) into the autoclave, reacting for 6 hours at the constant temperature of 120 ℃, naturally cooling to room temperature after the reaction is finished, taking out, washing with deionized water for several times, and drying in a vacuum oven at 60 ℃ overnight to obtain gamma-Fe on the surface of the foam nickel 2 O 3 @NiO magnetA sexual oxide nanoplatelet; the X-ray diffraction pattern of the nano-sheet is shown in figure 3, and the scanning electron microscope is shown in figure 4;
firstly, drawing spiral patterns required to be used in CAD software; secondly, fixing the foam nickel synthesized with the magnetic oxide nano-sheets on the heat release adhesive, and obtaining the pattern (1-5) in fig. 1 by laser cutting; transferring the pattern from the heat release adhesive to an inner layer Ecoflex package (1-8) with a micro-channel at 120 ℃, then arranging a reference electrode (1-4), a magnetic oxide nano-sheet sensing layer (1-5) and a counter electrode (1-6), arranging an electrochemical signal acquisition system (1-7) above the magnetic oxide nano-sheet sensing layer (1-5), placing the contact lens into a contact lens mold, and then packaging by using 55 mu m Ecoflex to obtain the flexible multifunctional cornea contact lens;
the reference electrode layer, the magnetic oxide nanosheet sensing layer and the counter electrode layer are all packaged on the same plane, and the total thickness is about 410 mu m;
and 4, realizing the electrical connection between the internal flexible multifunctional cornea contact lens and the external data acquisition and processing system, and preparing the flexible multifunctional cornea contact lens.
A physical view of the internal flexible multifunctional contact lens prepared in this example is shown in fig. 2.
FIG. 3 shows the synthesized gamma-Fe of the present invention 2 O 3 From the graph, the X-ray diffraction pattern of the nano sheet of the magnetic oxide of the@NiO can be seen, and the magnetic oxide gamma-Fe is successfully synthesized by adopting a one-step hydrothermal method 2 O 3 @NiO; FIG. 4 shows gamma-Fe of the present invention 2 O 3 Scanning electron microscope image of the nano-sheet of NiO magnetic oxide, from which it can be seen that the magnetic oxide is gamma-Fe 2 O 3 The @ NiO is in a nano sheet structure and is uniformly distributed in the porous foamOn nickel, the structure has larger specific surface area and rich active sites, and can show good performance in a three-electrode electrochemical system.
FIG. 5 shows a gamma-Fe-based alloy according to an embodiment of the present invention 2 O 3 Glucose test experiment diagram of@NiO magnetic oxide nanosheets, illustrating magnetic oxide gamma-Fe 2 O 3 The @ NiO has good electrochemical properties as an enzyme-free glucose sensor. The method comprises the following steps: FIG. 5 (a) shows the presence of 1mmol L -1 Glucose and in the absence of glucose, gamma-Fe 2 O 3 The cyclic voltammetric response of the @ NiO magnetic oxide nanoplatelets can be observed that the addition of glucose significantly enhances the current response, indicating gamma-Fe 2 O 3 the@NiO magnetic oxide nano sheet has obvious influence on glucose oxidation; FIG. 5 (b) shows an amperometric response of the glucose sensor to continuous addition of glucose at an oxidation voltage of +0.5V, FIGS. 5 (c) and 5 (d) being 0.005-0.5mmol L, respectively -1 And 1.0 to 6.0mmol L -1 A linear relationship of current density over a range with glucose concentration. The detection limit=relative standard deviation/slope, according to the formula, can be calculated to be 0.43 μm. FIG. 5 (e) is a graph of the effect of common interfering substances such as lactic acid, ascorbic acid and sodium chloride, and the current response of the interfering substances is observed to be very weak, in sharp contrast to the addition of 1.0mmol L -1 After glucose, the current increases rapidly, indicating a strong interference resistance. 10 gamma-Fe were synthesized by the method of the examples 2 O 3 The performance reproducibility of NiO magnetic oxide nanoplatelets was evaluated as shown in FIG. 5 (f), and CV curve tests were performed separately comparing each sample at 1.0mmoL -1 The peak current at glucose, the relative standard deviation of 10 determinations, was 5%, indicating that the sensor had good reproducibility.
FIG. 6 shows a gamma-Fe-based alloy according to an embodiment of the present invention 2 O 3 Fig. 6 (a) shows an nystagmus experimental diagram of NiO magnetic oxide nanoplatelets, simulating the movement of a multifunctional contact lens in 9 directions by fixing four tesla meters on external frame glasses, and then determining and analyzing the magnetic intensity heat map by using an intersection function, the specific principle is as follows:
assume that four tesla meters are numbered A, B, C and D in a clockwise order. Eyeball movement test points 1-9 are ordered according to I-IX in FIG. 6 (a):
F(A>C)＝{x|1,2,3}G(A≈C)＝{x|4,5,6}H(A<C)＝{x|7,8,9}
I(B>D)＝{x|3,6,9}J(B≈D)＝{x|2,5,8}K(B<D)＝{x|1,4,7}
for example, point 1=f n k. Likewise, points 2-9 are similarly obtained.
FIG. 6 (b) shows a magnetic oxide of gamma-Fe 2 O 3 The magnetic sensor continuously performs 10 times of magnetic tests on the@NiO, so that the accuracy is 95.27%, and the repeatability is good. FIG. 6 (c) by continuously moving the magnetic oxide gamma-Fe 2 O 3 The @ NiO simulates real-time movement of eyeballs in different directions, and records numerical changes of an external Tesla gauge, and the result shows that the actual movement track has high consistency with the corresponding magnetic intensity distribution.
FIG. 7 shows a gamma-Fe-based alloy according to an embodiment of the present invention 2 O 3 Fig. 7 (a) is a graph of intraocular pressure experiments on NiO magnetic oxide nanoplatelets, where the reflectance spectrum collected at a pressure of 6mmHg, a reflectance peak at 210.5 MHz was observed due to abrupt changes in coupling capacitance and inductance. As shown in fig. 7 (b), when the multifunctional contact lens is deformed with fluctuation of ocular hypertension, the inductance of the coupling capacitance increases and the reflection intensity value decreases. Fig. 7 (c) corresponding thereto shows that the resonant frequency of the sensor is positively correlated with the intraocular pressure.
FIG. 8 is a confocal microscope of an inner-layer micro-channel packaging film for a contact lens according to an embodiment of the present invention, which is just one specific embodiment, and all inner-layer packaging films (1-8) having micro-channels can realize tear flow through the inner-layer packaging films (1-8) and the reference electrode (1-4), the counter electrode (1-6) and gamma-Fe 2 O 3 The contact design of the nano-sheet sensing layers (1-5) of NiO magnetic oxide is in a protection range. As shown in FIG. 8, wherein (8-1) is a tear inlet and (8-2) is a tear outlet, the microfluidic channel is mainly composed of a serpentine channel, a quasi-circular channel and an electrode layer arrangement region, and the line width is 300. Mu.m. The serpentine design helps collect the tear water and completely moisturize the tear waterThe magnetic oxide nanosheet sensing layer, the reference electrode and the counter electrode. (8-3) is a reference electrode, (8-4) is a counter electrode, the line width is 300 mu m, and the arc length is-1.2 mm; (8-5) magnetic oxide nano-sheet sensing layer, line width is 300 μm, and interval is 300 μm.
While the invention has been described in terms of specific embodiments, any feature disclosed in this specification may be replaced by alternative features serving the equivalent or similar purpose, unless expressly stated otherwise; all of the features disclosed, or all of the steps in a method or process, except for mutually exclusive features and/or steps, may be combined in any manner.
Claims (10)
1. Gamma-Fe-based 2 O 3 Flexible multifunctional contact lens of NiO magnetic oxide nanoplatelets, characterized by comprising an external data acquisition and processing system (1-1) and an internal multifunctional contact lens (1-2);
the inner multifunctional cornea contact lens (1-2) comprises an outer packaging film (1-3) and gamma-Fe 2 O 3 The device comprises an @ NiO magnetic oxide nanosheet sensing layer (1-5), a reference electrode (1-4), a counter electrode (1-6), an electrochemical signal acquisition system (1-7) and an inner packaging film (1-8); wherein, reference electrode (1-4), gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet sensor (1-5) and the counter electrode (1-6) are respectively connected with the electrochemical signal acquisition system (1-7) through metal wires;
the reference electrode (1-4), gamma-Fe 2 O 3 The system comprises a three-electrode system formed by an NiO magnetic oxide nano-sheet sensing layer (1-5) and a counter electrode (1-6), and is used for detecting an electrochemical signal and transmitting the signal to an electrochemical signal acquisition system (1-7); the electrochemical signal acquisition system (1-7) translates and interprets the electric signals generated by the three-electrode system and then outputs glucose signals;
the external data acquisition and processing system (1-1) comprises a lens frame, a metal coil (1-9) and a tesla meter (1-10); the Tesla gauge (1-10) and the metal coil (1-9) are arranged on the glasses frame;
the metal coils (1-9) and gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet sensing layer (1-5) forms an intraocular pressure data acquisition system, so that the detection of an eye pressure signal is realized; said teslameter (1-10) and gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer (1-5) forms an nystagmus data acquisition system for realizing nystagmus signal detection;
the gamma-Fe 2 O 3 the@NiO magnetic oxide nanosheet is prepared by adding foam nickel by a one-step hydrothermal method, and the magnetic oxide gamma-Fe 2 O 3 The @ NiO is in a nano sheet structure and is uniformly distributed on the porous foam nickel.
2. The flexible multifunctional contact lens according to claim 1, wherein the inner packaging film (1-8) has a micro flow channel, tear fluid passes through the inner packaging film (1-8) and the reference electrode (1-4), the counter electrode (1-6) and γ -Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layers (1-5) are in contact.
3. A flexible multifunctional contact lens according to claim 1, characterized in that the number of teslameters (1-10) is 4, arranged in four symmetrical directions of the metal coil (1-9).
4. The flexible multi-functional contact lens of claim 1, wherein the gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer (1-5) is of a spiral structure.
5. The flexible multi-functional contact lens of claim 1, wherein the gamma-Fe 2 O 3 The @ NiO magnetic oxide nanosheet sensing layer is formed by cutting gamma-Fe by laser 2 O 3 The nano-sheet array of the NiO magnetic oxide is in a spiral structure.
6. The flexible multi-functional contact lens of claim 5, wherein in the range of bending deformation, γ -Fe 2 O 3 Spiral of @ NiO magnetic oxide nanosheet sensing layerThe smaller the line width of the structure is, the more spiral turns with the same area are, the more turns are, and the higher the detection precision is.
7. The flexible multi-functional contact lens of claim 6, wherein the line width of the spiral structure is 300 μm and the number of turns of the spiral structure is 3 to 5.
8. The flexible multifunctional contact lens of claim 1, wherein the reference electrode and the counter electrode are Ag/AgCl paste and Pt wire, respectively, and have an arc length of 1.2mm.
9. The flexible multifunctional contact lens of claim 1, wherein the metal coil is made of aluminum, silver or copper, and has a line width of 10 μm to 2mm.
10. The flexible multifunctional contact lens according to claim 1, wherein the outer packaging film and the inner packaging film are made of polymer cured products with Young's modulus of 10kPa to 100 MPa; the thickness of the packaging film is 50-60 mu m.
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| WO2008101374A2 (en) * | 2007-01-23 | 2008-08-28 | Tianjin Suowei Electronic Technology Co., Ltd. | Monitor device for measuring the pressure in the eye |
| CA2683467A1 (en) * | 2008-10-24 | 2010-04-24 | Jin Zhang | Contact lens integrated with a biosensor for detection of glucose and other components in tears |
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| US11291391B2 (en) * | 2017-12-11 | 2022-04-05 | Microoptx Inc. | Implantable ocular glucose sensor devices and methods |
| CN109793496A (en) * | 2018-12-04 | 2019-05-24 | 苏州大学 | A kind of device and the application of combination sensor and SS-OCT technical testing intraocular pressure |
| CN111407227B (en) * | 2019-01-04 | 2021-06-18 | 中国科学院半导体研究所 | Optical intraocular pressure detection device based on corneal contact lens and preparation and use methods |
| CN110013232B (en) * | 2019-04-28 | 2021-08-10 | 南京大学 | Eye sensor and preparation method |
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| CA2683467A1 (en) * | 2008-10-24 | 2010-04-24 | Jin Zhang | Contact lens integrated with a biosensor for detection of glucose and other components in tears |
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