CN113862705A - Electrochemical synthesis method of 2-aryl-3-halo-2H-indazole compound - Google Patents
Electrochemical synthesis method of 2-aryl-3-halo-2H-indazole compound Download PDFInfo
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- 238000001308 synthesis method Methods 0.000 title claims abstract description 10
- 238000006243 chemical reaction Methods 0.000 claims abstract description 42
- 125000002917 halogen containing inorganic group Chemical group 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000012046 mixed solvent Substances 0.000 claims abstract description 7
- 239000003960 organic solvent Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 52
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 40
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 18
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 229910052794 bromium Inorganic materials 0.000 claims description 10
- 229910052801 chlorine Inorganic materials 0.000 claims description 10
- 239000003480 eluent Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229910002804 graphite Inorganic materials 0.000 claims description 9
- 239000010439 graphite Substances 0.000 claims description 9
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000003786 synthesis reaction Methods 0.000 claims description 9
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 8
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 8
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims description 8
- 235000002639 sodium chloride Nutrition 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- -1 indazole compound Chemical class 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 238000005868 electrolysis reaction Methods 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 238000004440 column chromatography Methods 0.000 claims description 5
- 239000003208 petroleum Substances 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 claims description 4
- 235000019270 ammonium chloride Nutrition 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 4
- 235000011164 potassium chloride Nutrition 0.000 claims description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 230000002140 halogenating effect Effects 0.000 abstract description 2
- 229910017053 inorganic salt Inorganic materials 0.000 abstract description 2
- 239000007800 oxidant agent Substances 0.000 abstract description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 92
- 238000002360 preparation method Methods 0.000 description 41
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 23
- 238000005160 1H NMR spectroscopy Methods 0.000 description 23
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 20
- IXOZZKPZLXAEAX-UHFFFAOYSA-N 2-phenylindazole Chemical compound N1=C2C=CC=CC2=CN1C1=CC=CC=C1 IXOZZKPZLXAEAX-UHFFFAOYSA-N 0.000 description 18
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 6
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 5
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 4
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 4
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 150000002473 indoazoles Chemical class 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000005660 chlorination reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 3
- QTNQJALUHLNVKU-UHFFFAOYSA-N 2-(2-methylphenyl)indazole Chemical compound CC1=CC=CC=C1N1N=C2C=CC=CC2=C1 QTNQJALUHLNVKU-UHFFFAOYSA-N 0.000 description 2
- WMCUBOOKQAIXMG-UHFFFAOYSA-N 2-(3-chlorophenyl)indazole Chemical compound ClC1=CC=CC(N2N=C3C=CC=CC3=C2)=C1 WMCUBOOKQAIXMG-UHFFFAOYSA-N 0.000 description 2
- YNASDUYIEYUYOJ-UHFFFAOYSA-N 2-(4-bromophenyl)indazole Chemical compound C1=CC(Br)=CC=C1N1N=C2C=CC=CC2=C1 YNASDUYIEYUYOJ-UHFFFAOYSA-N 0.000 description 2
- CBIVOYLISNAAMT-UHFFFAOYSA-N 2-(4-chlorophenyl)indazole Chemical compound C1=CC(Cl)=CC=C1N1N=C2C=CC=CC2=C1 CBIVOYLISNAAMT-UHFFFAOYSA-N 0.000 description 2
- XESDDYSPKWRMMF-UHFFFAOYSA-N 2-(4-fluorophenyl)indazole Chemical compound C1=CC(F)=CC=C1N1N=C2C=CC=CC2=C1 XESDDYSPKWRMMF-UHFFFAOYSA-N 0.000 description 2
- NLTYZIXSXVXCKU-UHFFFAOYSA-N 2-(4-methylphenyl)indazole Chemical compound C1=CC(C)=CC=C1N1N=C2C=CC=CC2=C1 NLTYZIXSXVXCKU-UHFFFAOYSA-N 0.000 description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 2
- WZJZMVSJWUHDOB-UHFFFAOYSA-N 3-chloropyrrolidine-2,5-dione Chemical compound ClC1CC(=O)NC1=O WZJZMVSJWUHDOB-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-Chlorosuccinimide Substances ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 2
- 150000001555 benzenes Chemical class 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- IVCFCBFKOKSJOY-UHFFFAOYSA-N 2-(2-chlorophenyl)indazole Chemical compound ClC1=CC=CC=C1N1N=C2C=CC=CC2=C1 IVCFCBFKOKSJOY-UHFFFAOYSA-N 0.000 description 1
- BLEBOOVJJNMSCV-UHFFFAOYSA-N 2-(4-methoxyphenyl)indazole Chemical compound C1=CC(OC)=CC=C1N1N=C2C=CC=CC2=C1 BLEBOOVJJNMSCV-UHFFFAOYSA-N 0.000 description 1
- FIYIPGOIPMIGDR-UHFFFAOYSA-N 3-bromo-2-phenylindazole Chemical compound N1=C2C=CC=CC2=C(Br)N1C1=CC=CC=C1 FIYIPGOIPMIGDR-UHFFFAOYSA-N 0.000 description 1
- KNRKUCQCFWQBOZ-UHFFFAOYSA-N 3-chloro-2-phenylindazole Chemical compound N1=C2C=CC=CC2=C(Cl)N1C1=CC=CC=C1 KNRKUCQCFWQBOZ-UHFFFAOYSA-N 0.000 description 1
- VLRGXXKFHVJQOL-UHFFFAOYSA-N 3-chloropentane-2,4-dione Chemical compound CC(=O)C(Cl)C(C)=O VLRGXXKFHVJQOL-UHFFFAOYSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- SFXMQKSFVHQNKZ-UHFFFAOYSA-N 5-methoxy-2-(4-methylphenyl)indazole Chemical compound C1=C2C=C(OC)C=CC2=NN1C1=CC=C(C)C=C1 SFXMQKSFVHQNKZ-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000012320 chlorinating reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/01—Products
- C25B3/05—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/01—Products
- C25B3/09—Nitrogen containing compounds
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/01—Products
- C25B3/11—Halogen containing compounds
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/27—Halogenation
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a 2-aryl-3-halogeno-2HElectrochemical synthesis method of (E) -indazole compound (2-aryl-3-halogeno-2)HElectrochemical synthesis method of (E) -indazole compound, which is characterized in that mixed solvent consisting of water and organic solvent is added into an undivided electrolytic cell with a cathode and an anode, and then 2-aryl-2 is addedH-indazole compound and halogen-containing inorganic salt, stirring and electrolyzing at a certain temperature under the condition of constant current, and separating after the reaction is finished to obtain the 2-aryl-3-halogeno-2H-indazoles. The invention uses clean electric energy as oxidant and inorganic salt as halogenating agent, and has low cost,Is environment-friendly.
Description
Technical Field
The invention relates to a 2-aryl-3-halo-2HAn electrochemical synthesis method of the (E) -indazole compound.
Background
Heterocyclic compounds, particularly indazole compounds, have wide application in the fields of medicines, pesticides and polymers. Indazole compounds are vital in modern medicine research and development, and can be used as dopamine antagonist, anti-inflammatory and analgesicOr a antipyretic. In particular 2-aryl-2HIndazoles, which are important synthetic intermediates, are also key scaffolds for many bioactive molecules and fluorescent reagents.
In 2-aryl-2H2-aryl-3-halo-2HIndazoles as important members, such as 2-aryl-3-chloro-2HIndazoles and 2-aryl-3-bromo-2HIndazoles exhibit a particular biological activity (Journal of Medicinal Chemistry, 2005, 48, 1133-. In addition, 2-aryl-3-bromo-2HThe indazole compound is used as a raw material, and can be used for synthesizing a plurality of 2-aryl-substituted compounds with biological activity2HDerivatives of indazoles (Journal of medical Chemistry, 2005, 48, 1133. sup. 12144; Journal of Enzyme Inhibition and medical Chemistry, 2019, 34, 1-7; Pharmaceuticals, 2021, 14, 176).
For 2-aryl-3-chloro-2HIndazoles, one reported in the literature (Synthesis, 1979, (04), 302-N-(o-azidobenzoyl) -arylamine and thionyl chloride are taken as raw materials for synthesis; the more widely used method is now 2-aryl-2HThe indazole is directly chlorinated in the 3-position and is generally obtained asNChlorosuccinimide as chlorinating agent for chlorination (Chemical Communications, 2011, 47, 10133-. Preparation of 2-aryl-3-chloro-substituted benzene by direct chlorination method2HThe indazole compound has simple method and convenient operation, but stoichiometric amount is usedNChloro-succinimide is taken as a chlorination reagent, and stoichiometric by-product succinimide is generated during the reaction, so the method is not environment-friendly.
2-aryl-3-bromo-2HThe synthesis method of the (E) -indazole compound mainly comprises 2-aryl-2HThe indazole is obtained by taking elementary bromine as a brominating agent for bromination. 2-aryl-substituted benzene with elementary bromine2HThe method is simpler by brominating the (E) -indazole. However, as is well known, elemental bromine is toxic, volatile and inconvenient to use.
In view of the above, it is therefore necessary to develop a more ringIs environment-friendly, can conveniently and safely synthesize the 2-aryl-3-chloro-2HIndazoles and 2-aryl-3-bromo-2H-indazoles.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides 2-aryl-3-halo-2HAn electrochemical synthesis method of the (E) -indazole compound.
In order to achieve the purpose, the invention adopts the following technical scheme: adding a mixed solvent consisting of water and an organic solvent, and adding 2-aryl-2 in an undivided electrolytic cell having a cathode and an anodeH-indazole compound and halogen-containing inorganic salt, stirring and electrolyzing at a certain temperature under the condition of constant current, and separating after the reaction is finished to obtain the 2-aryl-3-halogeno-2H-indazoles;
said 2-aryl-2HThe structural formula of the (E) -indazole compound is shown as the formula (II), and the corresponding obtained 2-aryl-3-halogeno-2HThe structural formula of the indazole compound is shown as the formula (I):
in the formula (I) or formula (II), R1Is H, F, Cl, Br, NO2COOEt, C1-C4 alkyl or C1-C2 alkoxy, preferably H, F, Cl, Br, COOEt, methyl or methoxy; r2Is H, F, Cl, Br, NO2C1-C4 alkyl or C1-C2 alkoxy, preferably H, Cl or methoxy; r3Is Cl or Br.
In the invention, the halogen-containing inorganic salt is sodium chloride, potassium chloride, ammonium chloride, sodium bromide, potassium bromide or ammonium bromide.
Said 2-aryl-2H-the mass ratio between indazole-like compound and halogen-containing inorganic salt is 1: 1.5 to 2.5.
The organic solvent is methanol, acetonitrile, acetone,N,N-dimethylformamide orN,N-dimethylacetamide, preferably acetonitrile; the volume ratio of water to the organic solvent in the mixed solvent is 1: 4 to 30.
In the present invention, 2-aryl-2 is recommendedHThe amount concentration of the indazole compound in the mixed solvent is 0.01-0.04 mol/L.
The cathode is a graphite electrode or a platinum electrode, and the anode is a graphite electrode or a platinum electrode.
The electrolysis temperature is 25-75 ℃.
The electrolytic current is 2-20 mA.
The electrolysis time is 1-5 h.
The post-treatment method of the reaction liquid comprises the following steps: after the reaction is finished, the solvent is distilled off under reduced pressure, and then column chromatography separation is carried out, wherein the volume ratio of petroleum ether/ethyl acetate is 10: 1 as eluent, collecting the eluent containing the target compound, evaporating the solvent to obtain the product 2-aryl-3-halo-2H-indazoles.
The synthesis method provided by the invention is specifically recommended to be as follows: in an undivided electrolytic cell with two electrodes, a cathode and an anode, a solution of a mixed solution of a mixture of 1: 4-30 of a mixed solvent consisting of water and acetonitrile, and then adding 2-aryl-2HIndazole compounds and halogen-containing inorganic salts are subjected to stirring electrolysis reaction for 1-5 h under the constant current condition of 2-20 mA at the temperature of 25-75 ℃, the solvent is removed through reduced pressure distillation, and then column chromatography separation is performed, wherein the volume ratio of petroleum ether to ethyl acetate is 10: 1 as eluent, collecting the eluent containing the target compound, evaporating the solvent to obtain the product 2-aryl-3-halo-2H-indazoles. The halogen-containing inorganic salt is sodium chloride, potassium chloride, ammonium chloride, sodium bromide, potassium bromide or ammonium bromide. (ii) a Said 2-aryl-2H-the mass ratio between indazole-like compound and halogen-containing inorganic salt is 1: 1.5-2.5; the cathode is a graphite electrode or a platinum electrode, and the anode is a graphite electrode or a platinum electrode.
The synthesis method has the beneficial effects that: (1) clean electric energy is used as an oxidant; (2) inorganic salt is used as a halogenating reagent, so that the cost is low and the environment is friendly.
Detailed Description
The invention is further illustrated by the following specific examples, without limiting the scope of the invention thereto.
2-aryl-2HThe structural formulas of the indazoles are respectively shown as formulas (1-1) - (1-14):
correspondingly prepared 2-aryl-3-halogeno-2HThe structural formulas of the-indazole compounds are respectively shown as formulas (I-1) - (I-23):
example 1: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
In a 10ml undivided electrolytic cell with a graphite electrode as anode and a platinum electrode as cathode, 7ml of acetonitrile and 0.5ml of water were added, followed by 0.2mmol of 2-phenyl-2HIndazole (formula (II-1)) and 0.4mmol of sodium chloride were electrolyzed at 50 ℃ under a constant current of 5mA, and the reaction was completed after 2 hours. And (3) evaporating the solvent under reduced pressure, and then performing column chromatography separation, wherein the volume ratio of petroleum ether to ethyl acetate is 10: 1 as eluent, collecting the eluent containing the target compound, evaporating the solvent to obtain the product 2-phenyl-3-chloro-2HIndazole, yield 88%.
1H NMR (500 MHz, CDCl3) δ 7.76 – 7.72 (m, 3H), 7.65 (d, J = 7.1 Hz, 1H), 7.60 – 7.57 (m, 2H), 7.55 – 7.52 (m, 1H), 7.40 – 7.37 (m, 1H), 7.20 – 7.18 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 148.7, 138.7, 129.3, 127.8, 125.9, 123.0, 120.1, 119.7, 119.2 (2C), 118.4。
Example 2: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was the same as in example 1, except that the cathode was changed to a graphite electrode, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 85%.
Example 3: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was the same as in example 1, except that the anode was changed to a platinum electrode, 2-phenyl-3-chloro-2HThe yield of indazole was 84%.
Example 4: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that acetonitrile is replaced by methanol, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 49%.
Example 5: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that acetonitrile is replaced by acetone, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 72%.
Example 6: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that acetonitrile is replaced by acetonitrileN,N-dimethylformamide, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 57%.
Example 7: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that acetonitrile is replaced by acetonitrileN,N-dimethylacetamide, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 57%.
Example 8: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was as in example 1, except that the reaction temperature was changed to 25 ℃ and 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 54%.
Example 9: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was as in example 1, except that the reaction temperature was changed to 75 ℃ and 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 86%.
Example 10: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was the same as in example 1, except that sodium chloride was changed to potassium chloride, 2-phenyl-3-chloro-2HThe yield of indazole was 82%.
Example 11: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that sodium chloride is replaced by ammonium chloride, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 71%.
Example 12: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that the amount of sodium chloride is changed to 0.35mmol, 2-phenyl-3-chloro-2HThe yield of indazole was 78%.
Example 13: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 1, except that the amount of acetonitrile is changed to 6ml, the amount of water is changed to 1.5ml, and 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 61%.
Example 14: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was as in example 1, except that the current was changed to 8mA, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 81%.
Example 15: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was as in example 1, except that the current was changed to 2mA, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 33%.
Example 16: 2- (2-chlorophenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-2))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole to 2- (2-chlorophenyl) -2H-indazole (formula (II-2)), 2- (2-chlorophenyl) -3-chloro-2HThe yield of indazole was 80%.
1H NMR (500 MHz, CDCl3) δ 7.73 (d, J = 7.1 Hz, 1H), 7.64 (d, J = 7.1 Hz, 1H), 7.61 – 7.60 (m, 1H), 7.53 – 7.51 (m, 2H), 7.47 – 7.44 (m, 1H), 7.39 – 7.36 (m, 1H), 7.20 – 7.17 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 149.2, 136.4, 132.5, 131.6, 130.5, 129.7, 127.9, 127.7, 123.1, 122.0, 119.2, 119.0, 118.6。
Example 17: 2- (3-chlorophenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-3))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole to 2- (3-chlorophenyl) -2H-indazole (formula (II-3)), 2- (3-chlorophenyl) -3-chloro-2HThe yield of indazole was 82%.
1H NMR (500 MHz, CDCl3) δ 7.76 (s, 1H), 7.71 (d, J = 8.9 Hz, 1H), 7.65 – 7.60 (m, 2H), 7.48 – 7.47 (m, 2H), 7.37 – 7.34 (m, 1H), 7.18 – 7.15 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 148.9, 139.6, 135.0, 130.3, 129.4, 128.1, 126.1, 123.9, 123.3, 120.2, 119.7, 119.2, 118.4。
Example 18: 2- (4-chlorophenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-4))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole to 2- (4-chlorophenyl) -2H-indazole (formula (II-4)), 2- (4-chlorophenyl) -3-chloro-2HThe yield of (E) -indazole was 79%.
1H NMR (500 MHz, CDCl3) δ 7.71 – 7.66 (m, 3H), 7.62 (d, J = 8.5 Hz, 1H), 7.54 – 7.52 (m, 2H), 7.37 – 7.34 (m, 1H), 7.18 – 7.15 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 148.9, 137.2, 135.3, 129.5, 128.0, 127.0, 123.2, 120.2, 119.7, 119.2, 118.4。
Example 19: 2-phenyl-3, 5-dichloro-2HPreparation of (E) -indazole (formula (I-5))
The reaction procedure is as in example 1, except that 2-phenyl-2H2-phenyl-5-chloro-2 instead of indazoleH-indazole (formula (II-5)), 2-phenyl-3, 5-dichloro-2HThe yield of indazole was 84%.
1H NMR (500 MHz, CDCl3) δ 7.69 – 7.65 (m, 3H), 7.61 (d, J = 1.4 Hz, 1H), 7.57 – 7.55 (m, 3H), 7.29 – 7.26 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 147.05, 138.4, 129.5, 129.4, 129.3, 128.7, 125.8, 120.5, 120.0, 119.3, 117.9。
Example 20: 2- (4-bromophenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-6))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 2- (4-bromophenyl) -2H-indazole (formula (II-6)), 2- (4-bromophenyl) -3-chloro-2HThe yield of (E) -indazole was 85%.
1H NMR (500 MHz, CDCl3) δ 7.71 – 7.67 (m, 3H), 7.63 – 7.59 (m, 3H), 7.37 – 7.34 (m,1H), 7.18 – 7.15 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 148.7, 137.5, 132.3, 127.8, 127.1, 123.1, 123.0, 120.1, 119.4, 119.0, 118.2。
Example 21: 2- (4-fluorophenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-7))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 2- (4-fluorophenyl) -2H-indazole (formula (II-7)), 2- (4-fluorophenyl) -3-chloro-2HThe yield of (E) -indazole was 79%.
1H NMR (500 MHz, CDCl3) δ 7.73 – 7.68 (m, 3H), 7.63 (d, J = 8.5 Hz, 1H), 7.39 – 7.36 (m, 1H), 7.28 – 7.24 (m, 2H), 7.20 – 7.17 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 162.9 (d, J C-F = 248.4 Hz), 148.8, 134.8 (d, J C-F = 3.1 Hz), 127.9 (d, J C-F = 9.2 Hz), 127.8, 123.1, 120.0, 119.8, 119.1, 118.3, 116.3 (d, J C-F = 23.0 Hz)。
Example 22: 2- (2-methylphenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-8))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 2- (2-methylphenyl) -2HIndazole (formula (II-8)), 2- (2-methylphenyl) -3-chloro-2HThe yield of (E) -indazole was 70%.
1H NMR (500 MHz, CDCl3) δ 7.74 (d, J = 8.9 Hz, 1H), 7.65 (d, J = 8.9 Hz, 1H), 7.48 – 7.45 (m,1H), 7.40 – 7.36 (m, 4H), 7.20 – 7.17 (m, 1H), 2.00 (s, 1H); 13C NMR (125 MHz, CDCl3) δ 148.8, 137.7, 136.0, 131.1, 130.3, 127.8, 127.5, 126.8, 122.8, 121.1, 119.1, 118.9, 118.5, 17.4。
Example 23: 2- (4-methylphenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-9))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 2- (4-methylphenyl) -2H-indazole (formula (II-9)), 2- (4-methylphenyl) -3-chloro-2HThe yield of (E) -indazole was 63%.
1H NMR (500 MHz, CDCl3) δ 7.73 (d, J = 8.8 Hz, 1H), 7.63 (d, J = 8.8 Hz, 1H), 7.52 – 7.49 (m,2H), 7.44 – 7.41 (m, 1H), 7.37 – 7.30 (m, 2H), 7.18 – 7.15 (m, 1H), 2.47 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 148.7, 139.6, 138.6, 130.1, 127.7, 126.5, 122.9, 120.1, 119.6, 119.2, 118.4, 21.5。
Example 24: 4- (3-chloro-2)HPreparation of ethyl (E) -indazol-2-yl) benzoate (formula (I-10))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 4- (2)H-indazol-2-yl) benzoic acid ethyl ester (formula (II-10)), 4- (3-chloro-2-HThe yield of ethyl (E) -indazol-2-yl) benzoate was 61%.
1H NMR (500 MHz, CDCl3) δ 8.24 – 8.22 (m, 2H), 7.84 – 7.81 (m, 2H), 7.70 (d, J = 8.9 Hz, 1H), 7.61 (d, J = 8.9 Hz, 1H), 7.37 – 7.34 (m, 1H), 7.17 – 7.14 (m, 1H), 4.45 – 4.40 (m, 2H), 1.42 (t, J = 14.3 Hz, 3H); 13C NMR (125 MHz, CDCl3) δ 165.8, 149.1, 142.1, 131.0, 130.7, 128.2, 125.5, 123.3, 120.4, 119.7, 119.2, 118.4, 61.6, 14.5。
Example 25: 2- (4-methoxyphenyl) -3-chloro-2HPreparation of (E) -indazole (formula (I-11))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed to 2- (4-methoxyphenyl) -2H-indazole (formula (II-11)), 2- (4-methoxy group)Phenyl) -3-chloro-2HThe yield of (E) -indazole was 86%.
1H NMR (500 MHz, CDCl3) δ 7.71 (d, J = 8.8 Hz, 1H), 7.62 – 7.59 (m, 1H), 7.36 – 7.33 (m, 1H), 7.17 – 7.14 (m, 1H), 7.05 – 7.04 (m, 2H), 3.87 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 159.9, 148.2, 131.4, 127.2, 126.8, 122.5, 119.6, 119.4, 118.8, 118.0, 114.1, 55.4。
Example 26: 2-phenyl-3-chloro-5-methoxy-2HPreparation of (E) -indazole (formula (I-12))
The reaction procedure is as in example 1, except that 2-phenyl-2H2-phenyl-5-methoxy-2 instead of indazoleH-indazole (formula (II-12)), 2-phenyl-3-chloro-5-methoxy-2HThe yield of (E) -indazole was 72%.
1H NMR (500 MHz, CDCl3) δ 7.70 – 7.68 (m, 2H), 7.61 (d, J = 9.3 Hz, 1H), 7.55 – 7.52 (m, 2H), 7.49 – 7.48 (m, 1H), 7.07 – 7.04 (m, 1H), 6.77 (d, J = 2.3 Hz, 1H), 3.88 (s,3H); 13C NMR (125 MHz, CDCl3) δ 156.1, 145.7, 138.9, 129.3, 129.0, 125.7, 123.2, 120.1, 119.9, 118.1, 94.8, 55.7。
Example 27: 2- (4-methylphenyl) -3-chloro-5-methoxy-2HPreparation of (E) -indazole (formula (I-13))
The reaction procedure is as in example 1, except that 2-phenyl-2H-indazole is changed into 2- (4-methylphenyl) -5-methoxy-2H-indazole (formula (II-13)), 2- (4-methylphenyl) -3-chloro-5-methoxy-2HThe yield of (E) -indazole was 71%.
1H NMR (500 MHz, CDCl3) δ 7.62 – 7.60 (m, 2H), 7.57 – 7.54 (m, 2H), 7.33 (d, J = 8.1 Hz, 2H), 7.06 – 7.04 (m, 1H), 6.76 (d, J = 2.3 Hz, 1H); 13C NMR (125 MHz, CDCl3) δ 156.0, 145.5, 139.1 136.4, 129.8, 125.5, 123.0, 119.9, 119.8, 118.1, 94.8, 55.6, 21.4。
Example 28: 2-phenyl-3, 6-dichloro-2HPreparation of (E) -indazole (formula (I-14))
The reaction procedure is as in example 1, except that 2-phenyl-2H2-phenyl-6-chloro-2 instead of indazoleH-indazole (formula (II-14)), 2-phenyl-3, 6-dichloro-2HThe yield of indazole was 78%.
1H NMR (500 MHz, CDCl3) δ 7.71 – 7.66 (m, 3H), 7.58 – 7.51 (m, 4H), 7.12 – 7.10 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 148.5, 138.2, 133.6, 129.4, 129.2, 125.6, 124.4, 120.4, 120.3, 118.4, 117.1。
Example 29: 2-phenyl-3-bromo-2HPreparation of (E) -indazole (formula (I-15))
In a 10ml undivided electrolytic cell with a graphite electrode as anode and a platinum electrode as cathode, 7ml of acetonitrile and 0.5ml of water were added, followed by 0.2mmol of 2-phenyl-2HIndazole (formula (II-1)) and 0.4mmol of sodium bromide were electrolyzed at 50 ℃ under a constant current of 15mA, and the reaction was completed after 3 hours. And (3) evaporating the solvent under reduced pressure, and then performing column chromatography separation, wherein the volume ratio of petroleum ether to ethyl acetate is 10: 1 as eluent, collecting the eluent containing the target compound, evaporating the solvent to obtain the product 2-phenyl-3-bromo-2HIndazole, yield 85%.
1H NMR (500 MHz, CDCl3) δ 7.75 (d, J = 8.8 Hz, 1H), 7.69 – 7.67 (m, 2H), 7.60 – 7.51 (m, 4H), 7.39 – 7.35 (m, 1H), 7.20 – 7.17 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 149.4, 139.5, 129.4, 129.2, 127.8, 126.4, 123.2, 123.1, 119.9, 118.4, 106.3。
Example 30: 2-phenyl-3-bromo-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 29, except that potassium bromide, 2-phenyl-3-bromo-2, is used instead of sodium chlorideHThe yield of indazole was 80%.
Example 31: 2-phenyl-3-bromo-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure is as in example 29, except that sodium chloride is replaced by ammonium bromide, 2-phenyl-3-bromo-2HThe yield of (E) -indazole was 65%.
Example 32: 2-phenyl-3-chloro-2H-indazolesPreparation of (formula (I-1))
The reaction procedure was as in example 29, except that the current was changed to 10mA, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 47%.
Example 33: 2-phenyl-3-chloro-2HPreparation of (E) -indazole (formula (I-1))
The reaction procedure was as in example 29, except that the current was changed to 20mA, 2-phenyl-3-chloro-2HThe yield of (E) -indazole was 86%.
Example 34: 2- (3-chlorophenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-16))
The procedure is as in example 29, except that 2-phenyl-2H-indazole to 2- (3-chlorophenyl) -2H-indazole (formula (II-3)), 2- (3-chlorophenyl) -3-bromo-2HThe yield of indazole was 82%.
1H NMR (500 MHz, CDCl3) δ 7.74 – 7.72 (m, 2H), 7.76 – 7.56 (m, 2H), 7.48 – 7.47 (m, 2H), 7.38 – 7.35 (m, 1H), 7.19 – 7.16 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 149.6, 140.3, 135.0, 130.2, 129.6, 128.1, 126.7, 124.5, 123.5, 123.3, 119.9, 118.4, 106.3。
Example 35: 2- (4-chlorophenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-17))
The procedure is as in example 29, except that 2-phenyl-2H-indazole to 2- (4-chlorophenyl) -2H-indazole (formula (II-4)), 2- (4-chlorophenyl) -3-bromo-2HThe yield of indazole was 80%.
1H NMR (500 MHz, CDCl3) δ 7.72 (d, J = 8.8 Hz, 1H), 7.65 – 7.63 (m, 2H), 7.58 – 7.56 (m, 1H), 7.54 –7.52 (m, 2H), 7.39 – 7.35 (m, 1H), 7.20 – 7.17 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 149.6, 137.9, 135.5, 129.5, 128.0, 127.6, 123.4, 123.2, 119.9, 118.4, 106.3。
Example 36: 2-phenyl-3-bromo-5-chloro-2HPreparation of (E) -indazole (formula (I-18))
The procedure is as in example 29, except that 2-phenyl-2H2-phenyl-5-chloro-2 instead of indazoleHIndazole (formula (II-5)), 2-phenyl-3-bromo-5-chloro-2HThe yield of (E) -indazole was 81%.
1H NMR (500 MHz, CDCl3) δ 7.68 – 7.65 (m, 3H), 7.57 – 7.51 (m, 4H), 7.29 – 7.26 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 147.7, 139.2, 129.6, 129.3, 129.2, 128.9, 126.2, 123.5, 120.0, 118.6, 105.8。
Example 37: 2- (4-bromophenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-19))
The procedure is as in example 29, except that 2-phenyl-2H-indazole is changed to 2- (4-bromophenyl) -2H-indazole (formula (II-6)), 2- (4-bromophenyl) -3-bromo-2HThe yield of (E) -indazole was 83%.
1H NMR (500 MHz, CDCl3) δ 7.73 (d, J = 8.8 Hz, 1H), 7.69 – 7.66 (m, 2H), 7.59 – 7.55 (m, 3H), 7.38 – 7.35 (m, 1H), 7.19 – 7.16 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 149.5, 138.4, 132.4, 128.0, 127.7, 123.5, 123.4, 123.2, 119.8, 118.3, 106.2。
Example 38: 2- (4-fluorophenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-20))
The procedure is as in example 29, except that 2-phenyl-2H-indazole is changed to 2- (4-fluorophenyl) -2H-indazole (formula (II-7)), 2- (4-fluorophenyl) -3-bromo-2HThe yield of indazole was 78%.
1H NMR (500 MHz, CDCl3) δ 7.73 (d, J = 8.8 Hz, 1H), 7.69 – 7.66 (m, 2H), 7.59 – 7.55 (m, 3H), 7.38 – 7.35 (m, 1H); 13C NMR (125 MHz, CDCl3) δ 162.9 (d, J C-F = 248.4 Hz), 149.4, 135.5 (d, J C-F = 3.0 Hz), 128.3 (d, J C-F = 8.8 Hz), 127.9, 123.3, 123.1, 119.8, 118.3, 116.3 (d, J C-F = 23.0 Hz), 106.5。
Example 39: 2- (2-methylphenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-21))
Reaction stepThe same as example 29, except thatH-indazole is changed to 2- (2-methylphenyl) -2H-indazole (formula (II-8)), 2- (4-fluorophenyl) -3-bromo-2HThe isolation yield of the indazole was 80%.
1H NMR (500 MHz, CDCl3) δ 7.76 – 7.74 (m, 1H), 7.61 – 7.59 (m, 1H), 7.48 – 7.45 (m, 1H), 7.40 – 7.33 (m, 4H), 7.22 – 7.18 (m, 1H), 2.06 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 149.4, 138.6, 136.0, 131.1, 130.3, 127.9, 127.5, 126.7, 123.0, 122.0, 119.8, 118.5, 108.0, 17.5。
Example 40: 2- (4-methylphenyl) -3-bromo-2HPreparation of (E) -indazole (formula (I-22))
The procedure is as in example 29, except that 2-phenyl-2H-indazole is changed to 2- (4-methylphenyl) -2H-indazole (formula (II-9)), 2- (4-methylphenyl) -3-bromo-2HThe isolated yield of-indazole was 65%.
1H NMR (500 MHz, CDCl3) δ 7.74 (d, J = 8.8 Hz, 1H), 7.59 – 7.54 (m, 3H), 7.38 – 7.34 (m, 3H), 7.19 – 7.16 (m, 1H), 2.46 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 149.3, 139.6, 137.0, 129.8, 127.6, 126.1, 123.1, 123.0, 119.8, 118.3, 106.3, 21.5。
Example 41: 4- (3-bromo-2)HPreparation of ethyl (E) -indazol-2-yl) benzoate (formula (I-23))
The procedure is as in example 29, except that 2-phenyl-2H-indazole is changed to 4- (2)H-indazol-2-yl) benzoic acid ethyl ester (formula (II-10)), 4- (3-bromo-2)HThe yield of ethyl (E) -indazol-2-yl) benzoate was 77%.
1H NMR (500 MHz, CDCl3) δ 8.25 – 8.22 (m, 2H), 7.82 – 7.80 (m, 2H), 7.74 – 7.72 (m, 1H), 7.58 – 7.56 (m, 1H), 7.38 – 7.35 (m, 1H), 7.20 – 7.16 (m, 1H), 4.45 – 4.41 (m, 2H), 1.43 (t, J = 14.3 Hz, 3H); 13C NMR (125 MHz, CDCl3) δ 165.8, 149.7, 142.8, 131.2, 130.6, 128.2, 126.1, 123.5, 123.4, 119.9, 118.4, 106.2, 61.6, 14.5。
Claims (8)
1. 2-aryl-3-halo-2HElectrochemical synthesis method of (E) -indazole compound, which is characterized in that mixed solvent consisting of water and organic solvent is added into an undivided electrolytic cell with a cathode and an anode, and then 2-aryl-2 is addedH-indazole compound and halogen-containing inorganic salt, stirring and electrolyzing at a certain temperature under the condition of constant current, and separating after the reaction is finished to obtain the 2-aryl-3-halogeno-2H-indazoles;
said 2-aryl-2HThe structural formula of the (E) -indazole compound is shown as the formula (II), and the corresponding obtained 2-aryl-3-halogeno-2HThe structural formula of the indazole compound is shown as the formula (I):
in the formula (I) or formula (II), R1Is H, F, Cl, Br, NO2COOEt, C1-C4 alkyl or C1-C2 alkoxy, preferably H, F, Cl, Br, COOEt, methyl or methoxy; r2Is H, F, Cl, Br, NO2C1-C4 alkyl or C1-C2 alkoxy, preferably H, Cl or methoxy; r3Is Cl or Br.
2. The method of synthesis of claim 1, wherein: the halogen-containing inorganic salt is sodium chloride, potassium chloride, ammonium chloride, sodium bromide, potassium bromide or ammonium bromide.
3. The method of synthesis of claim 1, wherein: said 2-aryl-2H-the mass ratio between indazole-like compound and halogen-containing inorganic salt is 1: 1.5 to 2.5.
4. The method of synthesis of claim 1, wherein: the organic solvent is methanol, acetonitrile, acetone,N,N-dimethylformamide orN,N-dimethylacetamide, preferably acetonitrile; the mixed solventThe volume ratio of the medium water to the organic solvent is 1: 4 to 30.
5. The method of synthesis of claim 1, wherein: said 2-aryl-2HThe amount concentration of the indazole compound in the mixed solvent is 0.01-0.04 mol/L.
6. The method of synthesis of claim 1, wherein: the cathode is a graphite electrode or a platinum electrode, and the anode is a graphite electrode or a platinum electrode.
7. The method of synthesis of claim 1, wherein: the electrolysis temperature is 25-75 ℃, the electrolysis current is 2-20 mA, and the electrolysis time is 1-5 h.
8. The method of synthesis of claim 1, wherein: the post-treatment method of the reaction liquid comprises the following steps: after the reaction is finished, the solvent is distilled off under reduced pressure, and then column chromatography separation is carried out, wherein the volume ratio of petroleum ether/ethyl acetate is 10: 1 as eluent, collecting the eluent containing the target compound, evaporating the solvent to obtain the product 2-aryl-3-halo-2H-indazoles.
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