CN113828243B - Method and equipment for manufacturing nifuratel nystatin suppository - Google Patents
Method and equipment for manufacturing nifuratel nystatin suppository Download PDFInfo
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- CN113828243B CN113828243B CN202111071845.6A CN202111071845A CN113828243B CN 113828243 B CN113828243 B CN 113828243B CN 202111071845 A CN202111071845 A CN 202111071845A CN 113828243 B CN113828243 B CN 113828243B
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0004—Preparation of sols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/02—Particle separators, e.g. dust precipitators, having hollow filters made of flexible material
- B01D46/023—Pockets filters, i.e. multiple bag filters mounted on a common frame
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/28—Moving screens not otherwise provided for, e.g. swinging, reciprocating, rocking, tilting or wobbling screens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/42—Drive mechanisms, regulating or controlling devices, or balancing devices, specially adapted for screens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
- B07B1/4663—Multi-layer screening surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B2201/00—Details applicable to machines for screening using sieves or gratings
- B07B2201/04—Multiple deck screening devices comprising one or more superimposed screens
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Abstract
The invention relates to the technical field of drug manufacturing, in particular to a method and equipment for manufacturing nifuratel nystatin suppository; the first goods suppository that centrifugal spray granulator made, carry to the sack in, supply air to the drying cabinet in through the air supply subassembly, thereby dry the first goods suppository, after the drying is accomplished, start first electric putter, make the sack protruding, make the suppository after the drying under the action of gravity, drop to the collecting hopper in, and then carry to the screening incasement, loop through first screening mechanism and second screening mechanism, the suppository that will not conform to the specification size is sieved, thereby obtain the finished product suppository, compare in traditional mode, each process independently sets up, the manual intervention degree is higher, above-mentioned structure highly integrated, the manual intervention degree is lower, thereby improve the efficiency of preparation suppository.
Description
Technical Field
The invention relates to the technical field of medicine manufacturing, in particular to a method and equipment for manufacturing nifuratel nystatin suppository.
Background
Nifuratel (Nifuratel) is a broad-spectrum antibacterial drug belonging to furazolidone (this drug also includes furacilin, furadantin and furazolidone).
In the process of manufacturing the nifuratel nystatin suppository, the original suppository prepared by a centrifugal spray granulator needs to be dried and screened to obtain the finished suppository.
In the existing manufacturing process of the nifuratel nystatin suppository, most of devices for drying and screening the suppository as the primary product are independently arranged, and the degree of manual participation is higher, so that the production efficiency is lower.
Disclosure of Invention
The invention aims to provide a method and equipment for manufacturing nifuratel nystatin suppository, and solves the problems that in the existing manufacturing process of nifuratel nystatin suppository in the prior art, most of equipment for drying and screening the original suppository is independently arranged, the degree of manual participation is high, and the production efficiency is low.
In order to achieve the purpose, the invention provides equipment for manufacturing nifuratel nystatin suppository, which comprises a support frame, a drying unit, a collecting hopper and a screening unit, wherein a centrifugal spray granulator, the drying unit and the screening unit are sequentially arranged on the support frame from left to right;
The top of drying cabinet is provided with the sack, the output of air supply subassembly with the top of sack is corresponding, the inside of drying cabinet is provided with first electric putter, first electric putter's output with the middle part of sack is corresponding, the collecting hopper with the second leg is dismantled and is connected, and is located the bottom of drying cabinet, the collecting hopper is the funnel structure setting, the collecting hopper is kept away from the one end of drying cabinet is provided with the discharge gate, the screening unit includes screening box, first screening mechanism and second screening mechanism, be provided with the feed inlet on the screening box, the feed inlet with the discharge gate is corresponding, the inside of screening box has set gradually from top to bottom first screening mechanism with second screening mechanism.
The primary suppository prepared by the centrifugal spray granulator is conveyed to the interior of the cloth bag, air is supplied to the interior of the drying box through the air supply assembly, so that the primary suppository is dried, after the drying is completed, the first electric push rod is started, the cloth bag is protruded, the dried suppository falls to the interior of the material collecting hopper under the action of gravity, and then is conveyed to the interior of the screening box and sequentially passes through the first screening mechanism and the second screening mechanism to screen out the suppository which is not in accordance with the specification and size, so that a finished suppository is obtained, and compared with the traditional mode, each process is independently arranged, the manual intervention degree is higher, the structure is highly integrated, the manual intervention degree is lower, and the suppository preparation efficiency is improved.
The screening box is characterized in that a first discharge port and a second discharge port are further arranged on the outer side of the screening box, the first discharge port corresponds to the output end of the first screening mechanism, the second discharge port corresponds to the output end of the second screening mechanism, and a third discharge port is arranged at the bottom of the screening box.
The process first screening mechanism screens the back, and the first goods bougie that is greater than specification size passes through first bin outlet is retrieved, process second screening mechanism screens the back, and the first goods bougie that is less than specification size passes through the third bin outlet is retrieved, satisfies the finished product bougie of specification size and passes through the second bin outlet is collected.
The air supply assembly comprises a fan, an air supply pipe and a sealing cover, the sealing cover is arranged at one end, away from the support frame, of the first support, a placing plate is arranged in the middle of the first support, the fan is arranged on the placing plate, one end of the air supply pipe is detachably connected with the output end of the fan, the other end of the air supply pipe is detachably connected with an air inlet of the sealing cover, and the sealing cover corresponds to the cloth bag.
And starting the fan, and conveying the air treated by the air filter and the dehumidifier into the sealing cover through the air supply pipe, so as to dry the primary suppository in the cloth bag.
The first support comprises a support body, an inner column, a cantilever and a second electric push rod, one end of the support body is connected with the support frame in a detachable mode, a groove is formed in the other end of the support body, the second electric push rod is arranged inside the groove, one end of the inner column is connected with the output end of the second electric push rod in a detachable mode, the other end of the inner column is provided with the cantilever, and the sealing cover is arranged on the cantilever.
The inner column is pushed to ascend and descend by the aid of the second electric push rod, the sealing cover is arranged on the cantilever, and the second electric push rod is started, so that after the sealing cover is far away from the drying box, the primary suppository prepared by the centrifugal spray granulator is added into the cloth bag, and when drying is carried out, the sealing cover descends and is attached to the drying box, and accordingly the drying effect is better.
The support body comprises a fixing plate and a supporting column, the fixing plate is detachably connected with the supporting frame, one end of the supporting column is fixedly connected with the fixing plate, and the other end of the supporting column is provided with the groove.
Utilize the screw will the fixed plate is installed on the support frame, the support column with fixed plate fixed connection adopts the integrated into one piece technique to make during the manufacturing, and the structure is more firm.
The invention also provides a manufacturing method of the nifuratel nystatin suppository manufacturing equipment, which comprises the following steps:
mixing nifuratel, nystatin and promestrene uniformly to obtain a liquid medicine;
dissolving the water-based gel matrix in water to form a matrix solution, dissolving glycerol in water, mixing with the matrix solution, and adding ethylparaben and triethanolamine to obtain a gel matrix;
dissolving the liquid medicine in ethanol, adding water, adding into gel matrix under stirring, stirring to obtain nifuratel-nysfungin sol, adding into centrifugal spray granulating machine, and making into suppository;
and conveying the prepared primary suppository into the cloth bag, drying the primary suppository by the drying unit, conveying the primary suppository into the screening unit, and screening out the primary suppository which does not conform to the specification and size by the first screening mechanism and the second screening mechanism in sequence to obtain a finished suppository.
Firstly, uniformly mixing nifuratel, nystatin and promestrene to obtain a liquid medicine, simultaneously dissolving an aqueous gel matrix in water to form a matrix solution, dissolving glycerol in water, then mixing with the matrix solution, adding ethylparaben and triethanolamine to obtain a gel matrix, then dissolving the liquid medicine in ethanol, adding water, adding the water into the gel matrix under a stirring process, uniformly stirring to form nifuratel-nystatin sol, adding the nifuratel-nystatin sol into a centrifugal spray granulator to prepare a primary suppository, finally conveying the prepared primary suppository into the cloth bag, drying the gel matrix by the drying unit, conveying the gel bag into the sieving unit, and sieving the primary suppository which does not meet the specification size sequentially by the first sieving mechanism and the second sieving mechanism to obtain a finished suppository.
The invention relates to a method and a device for manufacturing nifuratel nystatin suppository, wherein a drying oven is provided with a feeding pipe, the feeding pipe corresponds to the output end of a centrifugal spray granulator, the top of the drying oven is provided with a cloth bag, the output end of an air supply component corresponds to the upper part of the cloth bag, the inside of the drying oven is provided with a first electric push rod, the output end of the first electric push rod corresponds to the middle part of the cloth bag, one end of a collecting hopper far away from the drying oven is provided with a discharge hole, the screening oven is provided with a feed hole, the feed hole corresponds to the discharge hole, the inside of the screening oven is sequentially provided with a first screening mechanism and a second screening mechanism from top to bottom, a primary suppository prepared by the centrifugal spray granulator is conveyed into the cloth bag and is supplied to the drying oven through the air supply component, thereby dry the first-class article suppository, dry the back of accomplishing, start first electric putter, make the sack is protruding for the suppository after the drying drops extremely under the action of gravity in the collecting hopper, and then carries extremely screening incasement loops through first screening mechanism with the second screening mechanism will not conform to the bougie screening of specification size to obtain the finished product suppository, compare in traditional mode, each process independent setting, the manual intervention degree is higher, and above-mentioned structure highly integrates, and the manual intervention degree is lower, thereby improves the efficiency of preparing the suppository.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a front view of a manufacturing apparatus of a nifuratel nystatin suppository provided by the present invention.
Fig. 2 is a sectional view of the internal structure taken along line a-a of fig. 1 according to the present invention.
Fig. 3 is a schematic structural view of a drying unit provided by the present invention.
Fig. 4 is a front view of a screening bin provided by the present invention.
Fig. 5 is a sectional view of the inner structure taken along line a-a of fig. 4 according to the present invention.
Fig. 6 is a schematic structural view of a first screening mechanism provided by the present invention.
FIG. 7 is a flow chart of the steps of the method for manufacturing nifuratel nystatin suppository provided by the present invention.
1-support frame, 2-drying unit, 21-first support, 211-placing plate, 212-support body, 213-inner column, 214-cantilever, 215-second electric push rod, 216-groove, 217-fixing plate, 218-support column, 22-air supply assembly, 221-fan, 222-air supply pipe, 223-sealing cover, 23-second support, 24-drying box, 241-feeding pipe, 242-cloth bag, 243-third electric push rod, 25-first electric push rod, 3-collecting hopper, 31-discharge port, 4-screening unit, 41-screening box, 42-first screening mechanism, 421-screening plate, 422-connecting piece, 423-shaking assembly, 4231-servo motor, 4232-output shaft, 4233-shaking cam, 424-placing block, 425-connecting block, 426-cross bar, 427-sliding shaft, 43-second screening mechanism, 44-feeding hole, 45-first discharging hole, 46-second discharging hole and 47-third discharging hole.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are illustrative and intended to explain the present invention and should not be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are merely for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. In addition, in the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Referring to fig. 1 to 6, the present invention provides a manufacturing apparatus of nifuratel nystatin suppository, which includes a support frame 1, a drying unit 2, a collection hopper 3 and a sieving unit 4, the supporting frame 1 is provided with a centrifugal spray granulator, the drying unit 2 and the screening unit 4 from left to right in sequence, the drying unit 2 comprises a first bracket 21, an air supply assembly 22, a second bracket 23, a drying box 24 and a first electric push rod 25, the first bracket 21 and the second bracket 23 are both detachably connected with the support frame 1, the air supply assembly 22 is arranged on the first bracket 21, the end, far away from the supporting frame 1, of the second bracket 23 is provided with the drying box 24, the drying box 24 is provided with a feeding pipe 241, and the feeding pipe 241 corresponds to the output end of the centrifugal spray granulator;
The top of the drying box 24 is provided with a cloth bag 242, the output end of the air supply component 22 corresponds to the upper part of the cloth bag 242, the inside of the drying box 24 is provided with the first electric push rod 25, the output end of the first electric push rod 25 corresponds to the middle part of the cloth bag 242, the aggregate bin 3 is detachably connected with the second bracket 23, and is positioned at the bottom of the drying box 24, the collecting hopper 3 is arranged in a funnel structure, a discharge hole 31 is arranged at one end of the collecting hopper 3 far away from the drying box 24, the screening unit 4 comprises a screening bin 41, a first screening mechanism 42 and a second screening mechanism 43, the screening box 41 is provided with a feed inlet 44, the feed inlet 44 corresponds to the discharge outlet 31, the inside of screening case 41 has from top to bottom set gradually first screening mechanism 42 with second screening mechanism 43.
In this embodiment, carry the first suppository that centrifugal spray granulator made to in sack 242, through air supply subassembly 22 to the drying cabinet 24 is interior to the air supply to dry the first suppository, after the drying is accomplished, start first electric putter 25, make sack 242 is protruding, make the suppository after the drying drop under the action of gravity to in the collecting hopper 3, and then carry to in screening case 41, loop through first screening mechanism 42 with second screening mechanism 43 will not conform to the suppository of specification size and remove, thereby obtain the finished product suppository, compare in traditional mode, each process independently sets up, and the manual intervention degree is higher, and above-mentioned structure highly integrates, and the manual intervention degree is lower, thereby improves the efficiency of preparing the suppository.
Further, the outside of screening case 41 still is provided with first bin outlet 45 and second bin outlet 46, first bin outlet 45 with the output of first screening mechanism 42 is corresponding, second bin outlet 46 with the output of second screening mechanism 43 is corresponding, the bottom of screening case 41 is provided with third bin outlet 47.
In this embodiment, through after first screening mechanism 42 filters, the first bougie that is greater than specification size passes through first bin outlet 45 retrieves, through after second screening mechanism 43 filters, the first bougie that is less than specification size passes through third bin outlet 47 retrieves, and the finished product bougie that satisfies specification size passes through second bin outlet 46 collects.
Further, the air supply assembly 22 includes a fan 221, an air supply pipe 222 and a sealing cover 223, the sealing cover 223 is disposed at one end of the first support 21 away from the support frame 1, a placing plate 211 is disposed at the middle of the first support 21, the fan 221 is disposed on the placing plate 211, one end of the air supply pipe 222 is detachably connected to an output end of the fan 221, the other end of the air supply pipe 222 is detachably connected to an air inlet of the sealing cover 223, and the sealing cover 223 corresponds to the cloth bag 242.
In the present embodiment, the blower 221 is activated to deliver the air, which has been treated by the air filter and the dehumidifier, into the sealing cover 223 through the air supply pipe 222, thereby drying the first suppository in the cloth bag 242.
Further, the first support 21 includes a support body 212, an inner column 213, a cantilever 214 and a second electric push rod 215, one end of the support body 212 is detachably connected to the support frame 1, the other end of the support body 212 is provided with a groove 216, the second electric push rod 215 is arranged inside the groove 216, one end of the inner column 213 is detachably connected to an output end of the second electric push rod 215, the other end of the inner column 213 is provided with the cantilever 214, the cantilever 214 is provided with the sealing cover 223, the support body 212 includes a fixing plate 217 and a support column 218, the fixing plate 217 is detachably connected to the support frame 1, one end of the support column 218 is fixedly connected to the fixing plate 217, and the other end of the support column 218 is provided with the groove 216.
In this embodiment, the second electric push rod 215 pushes the inner column 213 to move up and down, the cantilever 214 is provided with the sealing cover 223, the second electric push rod 215 is started, so that after the sealing cover 223 is far away from the drying box 24, the primary suppository prepared by the centrifugal spray granulator is added into the cloth bag 242, and when drying is performed, the sealing cover 223 descends to be attached to the drying box 24, so that the drying effect is better, the fixing plate 217 is mounted on the support frame 1 by using screws, and the support column 218 is fixedly connected with the fixing plate 217, and is manufactured by using an integral molding technology, so that the structure is firmer.
Further, a plurality of third electric push rods 243 are further disposed inside the drying box 24, the third electric push rods 243 are respectively located around the first electric push rod 25, and an output end of each third electric push rod 243 corresponds to the bottom of the cloth bag 242.
In this embodiment, when the air supply assembly 22 is used to dry the suppositories in the cloth bag 242, the third electric push rods 243 are activated to shake the cloth bag 242, so that the suppositories in the cloth bag 242 are turned over, and the drying effect is better.
Further, first screening mechanism 42 with second screening mechanism 43 all includes screening board 421, four connecting pieces 422 and shake subassembly 423, four extreme points department of screening board 421 all the activity is provided with connecting piece 422, every connecting piece 422 keeps away from the one end of screening board 421 all with the inner wall of screening case 41 is dismantled and is connected, it places piece 424 still to be provided with on the inner wall of screening case 41, it is provided with on the piece 424 to place shake subassembly 423, shake subassembly 423's output with screening board 421 is corresponding, the terminal surface of screening board 421 is the slope structure setting, the low of terminal surface respectively with first bin outlet 45 with second bin outlet 46 is corresponding.
In this embodiment, start shake subassembly 423, drive screening board 421 is in shake in the screening case 41 to the completion screening of speed is fast more, the terminal surface of screening board 421 is the inclined structure setting, makes the low department of suppository following the screening follow terminal surface, carries extremely first bin outlet 45 with second bin outlet 46 department.
Further, each connecting member 422 comprises a connecting block 425, a cross bar 426 and a sliding shaft 427, the connecting block 425 is detachably connected with the inner wall of the sieving box 41, one end of the cross bar 426 is fixedly connected with the connecting block 425, the other end of the cross bar 426 is provided with the sliding shaft 427, and the sieving plate 421 is slidably connected with the sliding shaft 427.
In this embodiment, the screening plate 421 is slidably connected to the sliding shaft 427, so that the shaking component 423 drives the screening plate 421 to slide on the sliding shaft 427, and the screening plate 421 is shaken, thereby improving the screening efficiency.
Further, each shaking assembly 423 comprises a servo motor 4231, an output shaft 4232 and a shaking cam 4233, the servo motor 4231 is detachably connected with the placing block 424, the output shaft 4232 is arranged at the output end of the servo motor 4231, the shaking cam 4233 is arranged on the output shaft 4232, and the shaking cam 4233 corresponds to the sieving plate 421.
In this embodiment, the servo motor 4231 is activated, the shaking cam 4233 is rotated by the output shaft 4232, and the sieving plate 421 is shaken by the shaking cam 4233.
Referring to fig. 7, the present invention further provides a manufacturing method of the nifuratel nystatin suppository manufacturing apparatus, including the following steps:
s1: mixing nifuratel, nystatin and promestrene uniformly to obtain a liquid medicine;
s2: dissolving the water-based gel matrix in water to form a matrix solution, dissolving glycerol in water, mixing with the matrix solution, and adding ethylparaben and triethanolamine to obtain a gel matrix;
s3: dissolving the liquid medicine in ethanol, adding water, adding into gel matrix under stirring, stirring to obtain nifuratel-nysfungin sol, adding into centrifugal spray granulating machine, and making into suppository;
s4: and conveying the prepared primary suppository into the cloth bag 242, drying the primary suppository by the drying unit 2, conveying the primary suppository into the screening unit 4, and screening out the primary suppository which does not meet the specification size by the first screening mechanism 42 and the second screening mechanism 43 in sequence to obtain the finished suppository.
In this embodiment, nifuratel, nystatin and promestrene are first mixed uniformly to obtain a drug solution, and simultaneously, an aqueous gel matrix is dissolved in water to form a matrix solution, glycerin is dissolved in water and then mixed with the matrix solution, and ethylparaben and triethanolamine are added to obtain a gel matrix, then the drug solution is dissolved in ethanol, water is added, the gel matrix is added under a stirring process, nifuratel-nystatin sol is formed after stirring uniformly, nifuratel-nystatin sol is added into a centrifugal spray granulator to prepare a primary suppository, finally the prepared primary suppository is conveyed into the cloth bag 242, dried by the drying unit 2 and conveyed into the sieving unit 4, the primary suppository which does not meet the specification size is sieved out by the first sieving mechanism 42 and the second sieving mechanism 43 in sequence, thereby obtaining the finished suppository.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (3)
1. A manufacturing device of nifuratel nystatin suppository, which is characterized in that,
the manufacturing equipment of the nifuratel nystatin suppository comprises a support frame, a drying unit, a collecting hopper and a screening unit, wherein a centrifugal spray granulator, the drying unit and the screening unit are sequentially arranged on the support frame from left to right, the drying unit comprises a first support, an air supply assembly, a second support, a drying box and a first electric push rod, the first support and the second support are detachably connected with the support frame, the air supply assembly is arranged on the first support, the drying box is arranged at one end, away from the support frame, of the second support, a feeding pipe is arranged on the drying box, and the feeding pipe corresponds to the output end of the centrifugal spray granulator;
the top of the drying box is provided with a cloth bag, the output end of the air supply assembly corresponds to the upper part of the cloth bag, the first electric push rod is arranged inside the drying box, the output end of the first electric push rod corresponds to the middle part of the cloth bag, the collecting hopper is detachably connected with the second support and is positioned at the bottom of the drying box, the collecting hopper is arranged in a funnel structure, one end, away from the drying box, of the collecting hopper is provided with a discharge hole, the screening unit comprises a screening box, a first screening mechanism and a second screening mechanism, a feed hole is formed in the screening box and corresponds to the discharge hole, and the first screening mechanism and the second screening mechanism are sequentially arranged inside the screening box from top to bottom;
The air supply assembly comprises a fan, an air supply pipe and a sealing cover, the sealing cover is arranged at one end of the first support far away from the support, a placing plate is arranged in the middle of the first bracket, the fan is arranged on the placing plate, one end of the blast pipe is detachably connected with the output end of the fan, the other end of the blast pipe is detachably connected with an air inlet of the sealing cover, the sealing cover corresponds to the cloth bag, the first support comprises a support body, an inner column, a cantilever and a second electric push rod, one end of the support body is detachably connected with the support frame, the other end of the frame body is provided with a groove, the second electric push rod is arranged in the groove, one end of the inner column is detachably connected with the output end of the second electric push rod, the other end of the inner column is provided with the cantilever, and the sealing cover is arranged on the cantilever.
2. The apparatus for producing nifuratel nystatin suppository according to claim 1,
the outside of screening case still is provided with first bin outlet and second bin outlet, first bin outlet with the output of first screening mechanism is corresponding, the second bin outlet with the output of second screening mechanism is corresponding, the bottom of screening case is provided with the third bin outlet.
3. The apparatus for producing nifuratel nystatin suppositories according to claim 1,
the support body includes fixed plate and support column, the fixed plate with the support frame is dismantled and is connected, the one end of support column with fixed plate fixed connection, the other end of support column is provided with the recess.
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| CN202111071845.6A CN113828243B (en) | 2021-09-14 | 2021-09-14 | Method and equipment for manufacturing nifuratel nystatin suppository |
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| CN202111071845.6A CN113828243B (en) | 2021-09-14 | 2021-09-14 | Method and equipment for manufacturing nifuratel nystatin suppository |
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