CN113808772A - 一种中子慢化材料 - Google Patents
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- 239000000463 material Substances 0.000 title claims abstract description 28
- 229910001635 magnesium fluoride Inorganic materials 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 238000011109 contamination Methods 0.000 description 9
- 230000004907 flux Effects 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 239000011812 mixed powder Substances 0.000 description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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Abstract
本发明涉及医疗技术领域,特别涉及一种中子慢化材料,包括Al元素、Mg元素、F元素、O元素以及Li元素,其中,以重量百分含量计,30.9%≦Al≦38.6%、27.4%≦Mg≦34.3%、5.4%≦F≦39.1%、1.8%≦O≦20.6%,0.8%≦Li≦1%。本发明包括Al、Mg、F、O、Li元素的中子慢化材料能使中子束符合IAEA要求品质。
Description
技术领域
本发明涉及医疗技术领域,特别涉及一种中子慢化材料。
背景技术
早在1936年,硼中子俘获疗法就作为一种潜在的癌症治疗手段被提出。它是利用含10B的靶向药物,通过注射或口服使之聚集在癌细胞中,经中子束照射通过后反应生成7Li和α粒子。它们具有高线性能量转移和高相对生物有效性,能对细胞产生致死性伤害;且穿透能力有限,大约为10μm,近似为一个细胞直径,从而将破坏力限制在单细胞尺度,从而免于伤害附近的正常组织细胞。
在肿瘤细胞内实现10B(n,α)7Li核反应的中子为热中子,目前普遍采用的是使用超热中子束照射,能量在0.5eV-10keV,中子在经过组织后会被慢化成热中子。超热中子拥有更强的穿透能力,因此可以治疗人体组织深处的癌细胞。国际原子能机构(IAEA)对用于BNCT治疗的中子束关于超热中子束通量、快中子(能量大于10keV)污染剂量比、光子污染剂量比以及热中子(能量小于0.5eV)污染比提出了如下的设计要求。
束流品质 | 要求值 |
超热中子束通量(φ<sub>epi</sub>) | ≥1×10<sup>9</sup>n·cm<sup>-2</sup>·s<sup>-1</sup> |
快中子污染剂量比(Dose<sub>f</sub>/φ<sub>epi</sub>) | ≤2×10<sup>-13</sup>Gy·cm<sup>2</sup> |
光子污染剂量比(Dose<sub>γ</sub>/φ<sub>epi</sub>) | ≤2×10<sup>-13</sup>Gy·cm<sup>2</sup> |
热中子污染比(φ<sub>th</sub>/φ<sub>epi</sub>) | ≤0.05 |
为得到满足上述要求的中子束,需要优秀的中子束型整流装置来对中子束进行加工,在束型整流装置中所用慢化材料决定了慢化层的优劣,更决定了中子束线的品质。
发明内容
本发明的目的克服现有技术中的问题,本发明一种中子慢化材料。
本发明的目的通过以下技术方案予以实现:
一种中子慢化材料,包括Al元素、Mg元素、F元素、O元素以及Li元素,其中,以重量百分含量计,30.9%≦Al≦38.6%、27.4%≦Mg≦34.3%、5.4%≦F≦39.1%、1.8%≦O≦20.6%,0.8%≦Li≦1%。
优选地,所述中子慢化材料的理论密度为2.1g/cm3~3.1g/cm3。
优选地,包括金属Al、MgF2、MgO和金属Li。
所述中子慢化材料在束型整流装置内作为慢化层的应用。
优选地,所述慢化层为将所述中子慢化材料以层叠或混合粉末压坯或混合粉末烧结的形式。
所述束型整流装置还包括慢化层外的反射层和屏蔽层、慢化层后的热中子吸收层及其他结构支撑部分。
所述束型整流装置用于基于加速器中子源的硼中子俘获治疗,所述加速器中子源包括加速器、被所述加速器加速的带电粒子束、用于引导所述带电粒子束的管道、经与所述带电粒子束发生核反应产生中子束的中子靶、以及用于调整经所述中子靶产生的中子束流品质的束型整流装置和射出经所诉整型后中子束出口,其中,所述中子靶在所述束型整流装置内。
与现有技术相比,本发明具有以下技术效果:
本发明公开的一种中子慢化材料,包括Al、Mg、F、O、Li元素的中子慢化材料能使中子束符合IAEA要求品质。
附图说明
图1BNCT中子束流整形装置示意图。图中1为反射层及屏蔽层,2为中子靶,3为慢化层,4为热中子吸收层。
具体实施方式
下面对本发明的具体实施方式作进一步说明。在此需要说明的是,对于这些实施方式的说明用于帮助理解本发明,但并不构成对本发明的限定。此外,下面所描述的本发明各个实施方式中所涉及的技术特征只要彼此之间未构成冲突就可以相互组合。
下述实验例中所使用的试验方法如无特殊说明,均为常规方法;所使用的材料、试剂等,如无特殊说明,为可从商业途径得到的试剂和材料。
实施例
一种中子慢化材料,包括Al元素、Mg元素、F元素、O元素以及Li元素;上述元素来自金属Al、MgF2、MgO和金属Li。Al、Mg、F、O、Li的含量如下表如下所示:
一种中子慢化材料,包括Al元素、Mg元素、F元素、O元素以及Li元素,其中,以重量百分含量计,30.9%≦Al≦38.6%、27.4%≦Mg≦34.3%、5.4%≦F≦39.1%、1.8%≦O≦20.6%,0.8%≦Li≦1%。
所述中子慢化材料的理论密度为2.1g/cm3~3.1g/cm3。
所述中子慢化材料在如图1所示的束型整流装置内作为慢化层的应用。
所述慢化层为将所述中子慢化材料以层叠或混合粉末压坯或混合粉末烧结的形式
实验例
1.超热中子束通量
BNCT治疗过程中,目前普遍采用的是使用超热中子束照射,能量在0.5eV-10keV,中子在经过组织后会被慢化成热中子。超热中子拥有更强的穿透能力,因此可以治疗人体组织深处的癌细胞。根据IAEA对中子束流品质的要求,其超热中子束通量应高于1×109n·cm-2·s-1。
2.快中子污染剂量比
在BNCT中,快中子为能量大于10keV的中子。快中子会给BNCT治疗带来额外不需要的辐照剂量。因此尽可能减少入射中子束中的快中子成分是BNCT束流设计的主要目标之一。根据IAEA对中子束流品质的要求,快中子剂量比上超热中子束通量应小于2×10-13Gy·cm2。
3.光子污染剂量比
在BNCT中,中子束中的光子也会给BNCT治疗带来额外不需要的辐照剂量。因此尽可能减少入射中子束中的光子成分也是BNCT束流设计的主要目标之一。根据IAEA对中子束流品质的要求,光子剂量比上超热中子束通量应小于2×10-13Gy·cm2。
4.热中子污染比
在BNCT中,热中子为能量小于0.5eV的中子。为了减少对皮肤的损伤,应尽量减少入射中子束中的热中子。热中子束通量与超热中子束通量比值的目标数应为0.05。
5.实施例各组满化材料中子束品质
以上所述仅为本发明专利的较佳实施例而已,并不用以限制本发明专利,凡在本发明专利的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明专利的保护范围之内。
Claims (5)
1.一种中子慢化材料,其特征在于,包括Al元素、Mg元素、F元素、O元素以及Li元素,其中,以重量百分含量计,30.9%≦Al≦38.6%、27.4%≦Mg≦34.3%、5.4%≦F≦39.1%、1.8%≦O≦20.6%,0.8%≦Li≦1%。
2.根据权利要求1所述中子慢化材料,其特征在于,所述中子慢化材料的理论密度为2.1g/cm3~3.1g/cm3。
3.根据权利要求1所述中子慢化材料,其特征在于,包括金属Al、MgF2、MgO和金属Li。
4.权利要求1~3任一项所述中子慢化材料在束型整流装置内作为慢化层的应用。
5.根据权利要求4所述应用,其特征在于,所述慢化层为将所述中子慢化材料以层叠或混合粉末压坯或混合粉末烧结的形式。
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