CN113808666A - DNA comparison analysis investigation system for ethnic group relativity - Google Patents
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- CN113808666A CN113808666A CN202011434552.5A CN202011434552A CN113808666A CN 113808666 A CN113808666 A CN 113808666A CN 202011434552 A CN202011434552 A CN 202011434552A CN 113808666 A CN113808666 A CN 113808666A
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Abstract
The invention relates to a DNA comparison analysis investigation system of ethnic group relatives, which comprises a case information input module, a case DNA information input module, case related personnel and DNA information input modules, a relativity information input module, a relativity DNA information comparison module, a single relation, a uncle, a nephew, a sibling and other relatives DNA information comparison module, a case comparison result collection module and a relative comparison result collection module. The invention utilizes the DNA technology of the autosome with different numbers and common allelic factors to compare and search out the personnel with the blood relative relationship, is mainly applied to quickly searching the related personnel of the case, and has the effects of fully mining the DNA information of the blood relative relationship attached to the sample, and quickly finding the target by utilizing the personnel which can be originally searched out to trace the clues of the blood relative relationship.
Description
Technical Field
The invention relates to the technical field of DNA comparison search relativity, in particular to a DNA comparison analysis investigation system for ethnic group relativity.
Background
DNA databases have played a great role in case investigation in China and other countries all over the world, and the current DNA databases include autosomal STR DNA databases and Y-STR DNA databases. The autosomal STR DNA database mainly aims at the same comparison between on-site material evidence and personnel and mainly performs individual identity identification. Based on the principle that Y-STR only has male inheritance, the Y-STR DNA database searches suspicious families by comparing Y-STR haplotypes, reduces the investigation range to families with the same Y-STR, and then determines a locking target through the identity of DNA.
However, the following problems exist in the prior art:
(1) if the object to be inspected can not be sampled, but the relatives of the object to be inspected can be collected, how to search out the relatives of the object to be inspected;
(2) the quantity of the checked samples is large. Thousands of people are often checked by the traditional method, DNA detection cost of tens of thousands of people is consumed, targets cannot be checked, and manual comparison is complicated and easy to omit;
(3) the basic modes of application of the Y-STR database are as follows: the Y haplotype is used for searching the family, and the autosomal DNA is used for checking in the family personnel to identify the target. However, due to historical population migration, families of the same or similar Y haplotypes are distributed in different regions; families of the same or similar Y haplotypes can also be large in the same region due to population proliferation. With the increase of the library building range and number of the Y-STR, more families are needed in the library building system, the number of people needing to be investigated is huge, the area is involved, and how to investigate can be carried out to quickly find the target.
The main reasons for the above problems are:
1. limitation of the autosomal STR DNA database:
(1) the database only contains the DNA of a specific person, and if the specific person does not build the database, even if the DNA of the on-site material evidence is detected, an investigation clue cannot be obtained in the same affirmed comparison mode;
(2) the database is built with DNA of a specific person, but as time goes by, the built person grows old or dies, and the comparison value is lost;
(3) genetic comparison in the existing DNA database is generally parent-child or spouse-child triplet comparison, and only full-database comparison is available, and the comparison object range cannot be set as required for comparison;
(4) the single parent comparison set in the existing DNA database is usually in a false comparison, and because the whole database comparison is only available, tens of thousands of pieces or even hundreds of thousands of pieces of information in the comparison are huge in quantity and have no directivity, the comparison value is lost, and the workload, the expenditure and the misleading investigation are increased.
2. Limitations of the Y-STR DNA database:
(1) Y-STR can only narrow the investigation range to the same family as Y-STR. However, for thousands of years, the same family has proliferated in different regions due to the migration of the population; in the same region, the same family is grown for hundreds of years, and has a large population and various variations. Therefore, the phenomenon that the Chinese traditional medicine is difficult to distinguish is caused, and great trouble is brought to investigation and solution solving;
(2) the social life condition is complex, and the situations of holding, private life and external movement exist, so that the conditions of the family in the system are variable and difficult to distinguish;
(3) the accuracy of the Y-STR haplotype of the existing kit is insufficient, and the families can not be distinguished;
(4) all of the above situations make it difficult to further search for a target object or target, and the comparison efficiency is low.
In summary, the following problems result:
the investigation sample is difficult to collect, and the DNA comparison is used for the investigation, mainly depending on the sample of the collecting personnel. With the enhancement of legal consciousness of people, samples are more and more difficult to collect; on the other hand, the family is mainly in rural areas, the group is mainly in rural areas, the workers enter the city along with the acceleration of the urbanization process, and people staying in the rural areas are mostly old people and children, so that the samples of the age group people are more difficult to collect.
The existing DNA database can only carry out one-to-one comparison and investigation, but cannot quickly investigate the specific relationship of monad, sibling, tertiary nephew, grandchild, cousin and the like with the investigated person, so that when the samples of father, mother and son or sibling, tertiary nephew, grandchild, cousin and the like of the investigated object are acquired, the samples are excluded, and the resources, the time and the investigation opportunity are greatly wasted.
At present, no database for automatically comparing and searching the specific relationships of single parent, sibling, uncle and nephew, grandchild, cousin and the like by using computer technology exists.
Disclosure of Invention
The invention aims to provide a DNA comparison analysis investigation system for ethnic group relativity.
The above object of the present invention is achieved by the following technical solutions:
a DNA comparison analysis investigation system for ethnic group relativity is characterized in that: the system comprises a case information input module, a case DNA information input module, case related personnel and DNA information input modules, a genetic information input module, a genetic DNA information input module, a genetic relationship DNA information comparison module, a case comparison result collection module and a genetic relationship comparison result collection module;
the case information input module is connected with the case DNA information input module, case related personnel and DNA information input module, the kindred information input module is connected with the kindred DNA information input module, the case related personnel and DNA information input module read case information from the case information input module to ensure that the case information and the DNA information of a case site are matched in a one-to-one mode, the kindred DNA information input module extracts the kindred information from the kindred information input module to ensure that the kindred DNA information and the kindred relationship are matched in a one-to-one mode;
the case DNA information input module, the case related personnel and DNA information input module and the genetic DNA information input module are all connected with the genetic relationship DNA information comparison module, and the genetic relationship DNA information comparison module is connected with the case comparison result collection module and the genetic relationship comparison result collection module.
Preferably, the DNA information input module and the genetic DNA information input module adopt an autosomal kit and a Y chromosome kit for information acquisition and input, and the autosomal kit comprises a PowerPlex21 kit, an Identifierplus kit, a Globalfiller kit and a GoldEye20A kit; the Y chromosome kit comprises a Y Filer Plus kit, a Y Filer Y41 kit and a Y casework kit.
Preferably, the information recorded in the case information recording module is used for recording and storing the person information, the material evidence information, the unknown cadaver information and the information of the investigators of the case by taking each case as an inlet; the genetic information input module is used for inputting and storing personnel information with known genetic relationships, the personnel information comprises information (hiding detailed identity information of related personnel and inputting only by numbers) of known personnel with the genetic relationships in inspectors capable of grabbing cases, and the case DNA information input module and the genetic DNA information input module are autosomal STR data, SNP data, Y-STR data and Y-SNP data.
Preferably, the comparison method of the ethnic group genetic DNA comparison analysis survey system is as follows:
(1) jointly analyzing the number of all different loci of the autosome, Y-STR and Y-SNP data to predict the single parent relationship;
(2) jointly analyzing the data of the identical loci of the autosomes, the common allelic factors, the SNP, the Y-STR and the Y-SNP to predict the holomorphic relationship;
(3) jointly analyzing the number of all different loci of the autosome and the common allele factors, and carrying out data-assisted analysis on the autosome SNP, the Y-STR and the Y-SNP to predict the relation between the uncle and the nephew;
(4) the method utilizes the joint analysis of the number of the completely different loci of the autosome and the common allelic factors and the auxiliary analysis of the data of the completely identical loci, the number of the autosomal SNPs, the Y-STR and the Y-SNP to predict the relationship among other blood relatives, such as unisex relationship, full-sibling relationship, tertiary nephew relationship, half-sibling relationship, grandchild relationship, coust relationship and coust relationship.
Preferably, the genetic information input module supports input of various known blood relationship, takes totally different numbers, totally same numbers, common allelic factors and SNP data of autosomal loci as cores, accumulates basic data, and explores laws and application values of secondary generation blood relationship and tertiary blood relationship of monads, holonomes, tertiary nephes, half-sibles, granddaurs, primary tertiary nephewines, primary couches, secondary couches and the like.
Noun and term interpretation:
1. the method is totally different:
the genotypes of the two samples at the same locus are completely different, namely completely different;
examples are:
person 1:
D8S1179：14/16
material evidence 1:
D8S1179：15/17
person 2:
D8S1179：13
material evidence 2:
D8S1179：15/17
that is, it is considered that person 1 and physical evidence 1, and person 2 and physical evidence 2 are all 1 in the D8S1179 locus.
2. All the same:
the genotypes of the two samples at the same locus are completely the same, namely the two samples are completely the same;
examples are: comparing the personnel and the material evidence, wherein both comprise a D8S1179 gene locus,
person 1:
D8S1179：14/16
material evidence 1:
D8S1179：14/16
person 2:
D8S1179：15
material evidence 2:
D8S1179：15
that is, it is considered that 1 of the two genes are identical at the D8S1179 locus for the person 1 and the material 1, and the person 2 and the material 2
3. Half the same:
only one of the genotypes of the two samples at the same locus is the same, namely the two samples are half the same;
by way of example only, it is possible to use,
person 1:
D8S1179：14/17
material evidence 1:
D8S1179：14/15
that is, it is considered that person 1 and material 1 are 1 and half identical at the D8S1179 locus.
4. Consensus allelic factor:
consensus allele 2+ half identity 1-kit or test system locus number (excluding sex loci) -number of all different loci + number of all identical loci.
5. Single parent relationship:
a single relationship refers to a biological parent-child (female) relationship or a parent-child (female) relationship.
6. Full sibling relationship: siblings with parents are called a full sibling relationship.
7. Tertiary (Tu) nephew relationship: the relationship between biological tertiary father/primary father (tertiary mother/primary mother) and nephew male (nephew female) is called tertiary (girl) nephew relationship.
8. Grandchild relationship: refers to the relationship between biological grandfather, grandmother, grandson and granddaughter.
9. Cousin (sister): the term broadly refers to the relationship of the collateral blood relatives within five doses except the siblings. One 10, a cousin (sister): a cousin homologous to a biological grandparent.
11. The Tang uncle and nephew: besides the relatives of the nephew, the relationship of the blood and collateral systems within five doses.
In conclusion, the beneficial technical effects of the invention are as follows:
1. the invention analyzes the DNA data association among the people with relationship of blood relatives by utilizing the DNA technology, is mainly applied to quickly searching the target object or the victim (innominate corpse) of a case, can fully mine the DNA information of the blood relatives attached to a sample by utilizing the invention, and quickly finds the target by utilizing the people which can be originally searched to trace the relationship clues of the blood relatives;
2. the method includes the steps that autosomal STRs and SNPs are utilized for typing, computer technology is combined with the comprehensive analysis of the number of all different loci and the common allelic factors, direct genetic relationships (uniparental relationships) and non-direct genetic relationships such as full siblings, half siblings, tertiary nephew, grand grandma, tertiary nephew in a hall, brother of the first generation and brother of the second generation are predicted, persons possibly having blood-parental relationships with STRs of on-site physical certificates or innominate cadavers are rapidly screened, and the application value of the persons is evaluated;
3. can clearly indicate the investigation direction and has the advantage of fully mining the DNA information of the sample. The invention can analyze various blood affinity information, can not only quickly find a target object or blood affinity clues of the target object, but also excavate potential personnel information which is not mastered by an investigator, technically solves the problems that the family is found by material evidence DNA and Y-STR but no people can be found (including hidden and unreported potential blood affinity and the like which are not easy to find or can not be investigated), provides assistance for case investigation of the investigator, has the effect of twice the result with half the effort, greatly improves case solving efficiency and saves human, financial and physical case solving costs.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
A DNA comparison analysis investigation system for ethnic group relativity is characterized in that: the system comprises a case information input module, a case DNA information input module, case related personnel and DNA information input modules, a genetic information input module, a genetic DNA information input module, a genetic relationship DNA information comparison module, a case comparison result collection module and a genetic relationship comparison result collection module;
the case information input module is connected with the case DNA information input module, case related personnel and DNA information input module, the kindred information input module is connected with the kindred DNA information input module, the case related personnel and DNA information input module read case information from the case information input module to ensure that the case information and the DNA information of a case site are matched in a one-to-one mode, the kindred DNA information input module extracts the kindred information from the kindred information input module to ensure that the kindred DNA information and the kindred relationship are matched in a one-to-one mode;
the case DNA information input module, the case related personnel and DNA information input module and the genetic DNA information input module are all connected with the genetic relationship DNA information comparison module, and the genetic relationship DNA information comparison module is connected with the case comparison result collection module and the genetic relationship comparison result collection module.
The DNA information input module and the genetic DNA information input module adopt an autosomal kit and a Y chromosome kit for information acquisition and input, and the autosomal kit comprises a PowerPlex21 kit, an Identifierplus kit, a GlobalFiler kit and a GoldEye20A kit; the Y chromosome kit comprises a Y Filer Plus kit, a Y Filer Y41 kit and a Y casework kit.
The information input in the case information input module is that the information of people at the time and the place of each case, material evidence information, information of a famous cadaver and the information of the investigators of the case are input and stored by taking each case as an entrance; the genetic information input module is used for inputting and storing personnel information with known genetic relationships, the personnel information comprises information (hiding detailed identity information of related personnel and inputting only by numbers) of known personnel with the genetic relationships in inspectors capable of grabbing cases, and the case DNA information input module and the genetic DNA information input module are autosomal STR data, SNP data, Y-STR data and Y-SNP data.
A comparison method of a DNA comparison analysis survey system for ethnic group relatives comprises the following steps:
(1) jointly analyzing the number of all different loci of the autosome, Y-STR and Y-SNP data to predict the single parent relationship;
(2) jointly analyzing the data of the identical loci of the autosomes, the common allelic factors, the SNP, the Y-STR and the Y-SNP to predict the holomorphic relationship;
(3) jointly analyzing the number of all different loci of the autosome and the common allele factors, and carrying out data-assisted analysis on the autosome SNP, the Y-STR and the Y-SNP to predict the relation between the uncle and the nephew;
(4) the method utilizes the joint analysis of the number of the completely different loci of the autosome and the common allelic factors and the auxiliary analysis of the data of the completely identical loci, the number of the autosomal SNPs, the Y-STR and the Y-SNP to predict the relationship among other blood relatives, such as unisex relationship, full-sibling relationship, tertiary nephew relationship, half-sibling relationship, grandchild relationship, coust relationship and coust relationship.
The genetic information input module supports input of various known blood relationship, takes totally different numbers, totally same numbers, common allelic factors and SNP data of autosomal loci as cores, accumulates basic data, and explores the laws and application values of secondary generation blood relationship and tertiary blood relationship of monads, full siblings, tertiary nephew, half siblings, grand, tertiary nephew, primary cousin, secondary cousin and the like. Use case:
typical case 1
Brief case
In the year 2000, 11/29/18, a company in a certain area is killed by Zhao certain (female, 51 years old), Li certain (female, 88 years old) mother and Guo certain (female, 16 years old) nurse at home, and after a case is developed, relevant organizations invest huge manpower and material resources to solve the case and solve the case, but the case is trapped in a stiff office and is not detected for a long time due to the technical conditions at that time.
The related institution checks the material evidence of the case again to obtain the Y-STR of the target object, compares the Wujia family in a certain place, the Qin family in a certain place and other families through the Y-STR, brings great confusion to investigators in the face of complex comparison results, and then quickly predicts the blood relationship of the Tang Xian Shen from 34 samples of the investigators in the multiple families in the multiple places by utilizing the invention.
Survey process
In 2016, 6 months, the relevant organizations re-examined a little about 3mmX4mm skin left by the target subject in the field, which is an important material of the case, and determined 26Y-STR data and 18 common STR data.
The scheme Y-STR compares certain military family and certain Qin family in the DNA database of certain male family, relevant families in the regions are investigated and sampled, 399 person samples are successively collected, but no case-solving clues are found, 12 months and 8 days, 34 samples are collected by an investigator, help is sought and the invention is applied to investigation, the inventor utilizes the invention to carry out general comparison analysis, finds that the second-level blood relationship possibly exists between Qin and target object DNA in certain Qin family, and thus, the target object is quickly found.
TABLE 1 STR typing and comparison results of the frequently-stained STR between Qin Yuan and physical evidence skin
The information is fed back to the workgroup quickly, and through investigation, no suspicious person exists in a certain Qin, and the investigator learns that a certain father in Qin has a brother and a certain peng in Qin through further investigation, the person moves to the homework in the 50 s, the person has 3 children, 7 grandchildren and 2 recurrences, the workgroup further visits to find an important clue, a certain valuable element of the grandchild of the certain peng in Qin has worked in a certain company in Zhengzhou in the later year, and then the suspicion of a certain valuable in Qin, namely a certain Tang and a new jade in Qin, rises quickly.
The work group collects samples of the father Qin's version of Qin's version on 12 months and 13 days for inspection, the Qin's version and the material evidence accord with the single parent relationship through DNA inspection, after the Qin's version is captured, the DNA of the Qin's version and the material evidence skin DNA are completely consistent through inspection, and at this time, the target object Qin's version can be rapidly determined only through 34 parts of investigation samples.
By 16 th month 1 of 2017, the work group successively found some bright (male, age 44) in qin, some fellow coworkers (age 45) and some desk (male, age 43) as target objects of the pattern.
Typical case 2
Brief case
16 days 19 at 8 months in 2003, a female corpse was found in 300 m west of West refuse factory in certain village in certain city, and a student who became a dead was examined and studied, and a student in middle school went to be slow (12 years old).
Survey process
After a case is developed, a male autosome STR is detected from a victim vaginal swab, indifferent information in a national DNA database is recorded, a malignant case of old women with rape is developed in the fields of neighborhood and village 9 and 16 2003, the DNA detection of the victim vaginal swab is consistent with the data of the autosome STR of the case 2003.8.16, and the cases are combined, but no case is always developed.
Later, the case has consistent three case autosomal STR data in the national DNA database compared with the field physical evidence mask of the '2011.8.16' case in the other city, and cases are connected in series and parallel across regions.
In 12 months in 2017, the autosomal DNA and the Y-STR data of 27 loci of the target object are checked again through material evidence, and a family of the first Jisurname in one village and a family of the first king surname in the other village are compared in a database. After investigation, the two families are both from a village in the neighborhood, about one thousand of male people are required to be investigated by the family of the Ji family, and the situation of the local family is not clear. In 2017, 12 and 28 days, 47 samples are collected by investigators for inspection, and the study is used for comparing a nephew with a possible nephew-blood relationship between a cloud of a Ji and a target object.
The information is quickly fed back to the workgroup, and surveyors survey that some of the Ji cloud families have a track of activity in another city, and the Ji cloud family is a nephew of the Ji cloud and the Ji cloud family becomes a key target object. The surveyor acquires a sample of the round of Ji-Chi-z, and the round of Ji-Chi-z and the individual to which the material evidence belongs accord with the grandparent-grandparent relationship through inspection and analysis, so that the target object of Ji-Chi-grand-child is further locked.
TABLE 2 materials, profiles and comparisons of autosomal STR from Ji-somewhat Yun and Ji-somewhat Yuan
In 12 and 27 months in 2017, a workgroup captures a target object Ji somewhere in the remote province, and the test shows that the STR type of the target object Ji somewhere autosome is consistent with the field material evidence, so that the target object is identified, so that a series of cases spanning 14 years are successfully broken, and the investigation direction is rapidly indicated for an investigator only by 47 samples, namely locking clues, so that a large amount of manpower and material resources are saved, and the case solving time is greatly shortened.
The implementation principle of the embodiment is as follows:
(1) predicting other blood relatives such as a tertiary nephew relationship, a half-sib relationship, a grandchild relationship, a cousin relationship and a cousin relationship by utilizing the joint analysis of the number of all different loci and the number of common alleles of autosomes and the assistance of Y-STR and Y-SNP;
(2) the uniparental relation is predicted by utilizing the joint analysis of the number of different loci of the autosome, Y-STR and Y-SNP data;
(3) the number of the identical loci and the common allele factors of the autosomes are jointly analyzed with Y-STR and Y-SNP data to predict the holomorphic relation;
(4) case-related investigators of each case are managed independently according to related cases: taking each case as an entrance, inputting and storing case material evidence information, autosomal STR data, Y-STR and Y-SNP data, case related investigator information, autosomal STR data, Y-STR and Y-SNP data; the information and DNA data of the examiners of the case are managed and used independently; the case-related inspectors of each case are not related to other case inspectors on the management module;
(5) intelligent comparison function: expressing the core DNA comparison algorithm by software through regular comparison of DNA comparison algorithm (number of all different loci, number of all identical loci, number of common allele factors, number of loci of kit or detection system (excluding sex loci) -number of all different loci + number of all identical loci);
firstly, different types of blood relationship comparison can be carried out, including the same comparison, single parent, full sibling, tertiary nephew, half sibling, grandchild and cousin and other blood relationship;
and the possible relationship between the personnel and the material evidence is checked out, so that clues and definite investigation directions are provided for the investigators.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.
Claims (5)
1. A DNA comparison analysis investigation system for ethnic group relativity is characterized in that: the system comprises a case information input module, a case DNA information input module, case related personnel and DNA information input modules, a genetic information input module, a genetic DNA information input module, a genetic relationship DNA information comparison module, a case comparison result collection module and a genetic relationship comparison result collection module;
the case information input module is connected with the case DNA information input module, case related personnel and DNA information input module, the kindred information input module is connected with the kindred DNA information input module, the case related personnel and DNA information input module read case information from the case information input module to ensure that the case information and the DNA information of a case site are matched in a one-to-one mode, the kindred DNA information input module extracts the kindred information from the kindred information input module to ensure that the kindred DNA information and the kindred relationship are matched in a one-to-one mode;
the case DNA information input module, the case related personnel and DNA information input module and the genetic DNA information input module are all connected with the genetic relationship DNA information comparison module, and the genetic relationship DNA information comparison module is connected with the case comparison result collection module and the genetic relationship comparison result collection module.
2. The system according to claim 1, wherein the system comprises: the DNA information input module and the genetic DNA information input module adopt an autosomal kit and a Y chromosome kit for information acquisition and input, and the autosomal kit comprises a PowerPlex21 kit, an Identifierplus kit, a GlobalFiler kit and a GoldEye20A kit; the Y chromosome kit comprises a Y Filer Plus kit, a Y Filer Y41 kit and a Y casework kit.
3. The system according to claim 1, wherein the system comprises: the information input in the case information input module is that the information of people at the time and the place of each case, material evidence information, information of a famous cadaver and the information of the investigators of the case are input and stored by taking each case as an entrance; the genetic information input module is used for inputting and storing personnel information with known genetic relationships, the personnel information comprises information (hiding detailed identity information of related personnel and inputting only by numbers) of known personnel with the genetic relationships in inspectors capable of grabbing cases, and the case DNA information input module and the genetic DNA information input module are autosomal STR data, SNP data, Y-STR data and Y-SNP data.
4. The system according to claim 1 or 3, wherein the DNA alignment analysis survey system comprises: the comparison method specifically comprises the following steps:
(1) jointly analyzing the number of all different loci of the autosome, Y-STR and Y-SNP data to predict the single parent relationship;
(2) jointly analyzing the data of the identical loci of the autosomes, the common allelic factors, the SNP, the Y-STR and the Y-SNP to predict the holomorphic relationship;
(3) jointly analyzing the number of all different loci of the autosome and the common allele factors, and carrying out data-assisted analysis on the autosome SNP, the Y-STR and the Y-SNP to predict the relation between the uncle and the nephew;
(4) the method utilizes the joint analysis of the number of the completely different loci of the autosome and the common allelic factors and the auxiliary analysis of the data of the completely identical loci, the number of the autosomal SNPs, the Y-STR and the Y-SNP to predict the relationship among other blood relatives, such as unisex relationship, full-sibling relationship, tertiary nephew relationship, half-sibling relationship, grandchild relationship, coust relationship and coust relationship.
5. The system according to claim 3, wherein the DNA alignment analysis survey system comprises: the genetic information input module supports input of various known blood relationship, takes totally different numbers, totally same numbers, common allelic factors and SNP data of autosomal loci as cores, accumulates basic data, and explores the laws and application values of secondary generation blood relationship and tertiary blood relationship of monads, full siblings, tertiary nephew, half siblings, grand, tertiary nephew, primary cousin, secondary cousin and the like.
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| TWI807861B (en) * | 2022-06-15 | 2023-07-01 | 中國醫藥大學 | Method for identifying affinity of taiwanese population and system thereof |
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| TWI807861B (en) * | 2022-06-15 | 2023-07-01 | 中國醫藥大學 | Method for identifying affinity of taiwanese population and system thereof |
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