CN113800100A

CN113800100A - Gene detection's sample collection system

Info

Publication number: CN113800100A
Application number: CN202010584992.2A
Authority: CN
Inventors: 杨荣
Original assignee: Cancer Hospital of Shandong First Medical University
Current assignee: Cancer Hospital of Shandong First Medical University
Priority date: 2020-06-16
Filing date: 2020-06-16
Publication date: 2021-12-17
Anticipated expiration: 2040-06-16
Also published as: CN113800100B

Abstract

The invention provides a sample collecting device for gene detection. The sample collection system that gene detected is including gathering the bin, the portable structure, the structure is stored to the layering, the collection structure, induce saliva structure and quick seal structure, store the structure in the layering of storing more model data and connect in the inside of gathering the bin, the layering is stored the structure and is included the U-shaped pull rod, the cystosepiment, splint, the round pin axle, pressure-bearing flange and gag lever post, gather the cystosepiment that the bin inside was equipped with a plurality of and stacks, the top surface of cystosepiment is equipped with the accumulator that a plurality of quantity evenly set up, cystosepiment both sides wall bottom is equipped with a plurality of pressure-bearing flange respectively. The sample collecting device for gene detection provided by the invention has the advantages that the foam board is quickly and portably lifted, the stacking or taking-out process of the foam board is conveniently controlled, the number of the foam boards stored in the collecting and storing box is increased, the space utilization rate is ensured, and a large number of gene detection samples are accommodated.

Description

Gene detection's sample collection system

Technical Field

The invention relates to the technical field of collection devices, in particular to a sample collection device for gene detection.

Background

The gene is a functional fragment on a DNA molecule, is a basic unit of genetic information, and is the most basic factor for determining all biological species; the gene determines the life, the old and the death of the human, is the reason for health, beauty and longevity, and is the operator and the regulator of the life. Therefore, where there is life and where there is a gene, the existence and form of death of all life are determined by the gene, including your growth, height, weight, complexion, character, etc. are closely related to the gene. The gene detection is a technology for detecting DNA through blood, other body fluids or cells, which is to take oral mucosa cells or other tissue cells dropped by a detected person, amplify the gene information, detect DNA molecular information in the cells of the detected person through specific equipment, predict the risk of the body suffering from diseases, analyze various gene conditions contained in the cells, enable people to know the own gene information, and avoid or delay the occurrence of the diseases by improving the living environment and the living habits of the people.

At present gene detection adopts saliva collection mode, the single-row cystosepiment often only can be stored to the collection collecting box of tradition, it is less to gather gene model data content, in the face of a large amount of gene samples, need use a plurality of collection collecting boxes, transport complex operation, and the sample collection process, inside the test tube is directly collected saliva, need the manual work to twist the sealing plug screw thread, it is sealed slow, sneak into a large amount of air in the external world easily, influence easily and gather gene sample quality.

Therefore, there is a need to provide a new sample collecting device for gene detection to solve the above-mentioned technical problems.

Disclosure of Invention

In order to solve the technical problems, the invention provides the sample collecting device for gene detection, which can quickly and portably put forward the foam boards, is convenient for controlling the stacking or taking-out process of the foam boards, can increase the number of the foam boards stored in the collecting and storing box, ensures the space utilization rate and contains a large number of gene detection samples.

The invention provides a sample collecting device for gene detection, which comprises: the top of the collection storage box is open, and a matched cover box is arranged at the top of the collection storage box; the portable structure for moving and transferring is connected with the collection storage box; the layered storage structure is used for storing more sample plate data and is connected to the inside of the acquisition storage box, the layered storage structure comprises a U-shaped pull rod, foam plates, a clamping plate, a pin shaft, a pressure-bearing convex plate and a limiting rod, a plurality of stacked foam plates are arranged inside the acquisition storage box, a plurality of storage grooves which are uniformly arranged in quantity are formed in the top surface of each foam plate, a plurality of pressure-bearing convex plates are respectively arranged at the bottoms of two side walls of each foam plate, the positions, close to the pressure-bearing convex plates, of two side surfaces inside the acquisition storage box are respectively and fixedly connected with the clamping plate, the clamping plate is rotatably connected with the pressure-bearing convex plate through the pin shaft, a notch is formed in the top of the outer side wall of each pressure-bearing convex plate, the side surface of the bottom of the rotating end of each pressure-bearing convex plate is connected with the limiting rod which is obliquely arranged, and the tops of the two side walls of each foam plate are respectively and fixedly connected with the U-shaped pull rod; the collection structure is used for storing saliva and is connected with the foam board; an induced saliva structure for inducing rapid secretion of a large amount of saliva in the mouth connected to the collection structure; the quick sealing structure is used for reducing the mixing amount of the outside air and the collected saliva and is connected with the collecting structure.

Preferably, two side surfaces inside the collecting and storing box are respectively provided with arc-shaped grooves matched with the limiting rods.

Preferably, the portable structure includes clamp bolt, diaphragm, riser, locking universal wheel and U-shaped rotary rod, gathers the inside spout that is equipped with two parallel arrangement respectively of bin both sides face, the inside sliding connection riser of spout, the locking universal wheel is connected to the bottom of riser, through diaphragm fixed connection between two adjacent riser bottoms, gathers bin bottom position both sides face threaded connection clamp bolt, gathers the bin top and rotates the U-shaped rotary rod of connecting two symmetry settings.

Preferably, the collection structure includes funnel cover, connecting band, sealing plug and collects the test tube, and the collection test tube has been placed to the inside of hold up tank, collects the top intercommunication funnel cover of test tube, collects test tube top lateral wall and passes through the connecting band and connect the sealing plug, sealing plug and the mouth of pipe threaded connection who collects the test tube.

Preferably, the saliva inducing structure comprises a hose, a cushion block, an acid storage tube, an installation plug and a nasal obstruction conical block, the outer side wall of the top end of the collection test tube is fixedly connected with the acid storage tube, the installation plug is installed on the top end of the acid storage tube, the top end of the installation plug is communicated with the hoses symmetrically arranged, the cushion blocks symmetrically arranged are fixed on the outer side wall of the bottom end of the acid storage tube, the other end of the hose is fixedly connected with the nasal obstruction conical block, the tops of the cushion blocks are provided with conical grooves matched with the nasal obstruction conical block, and a through hole communicated with the hose is formed in the nasal obstruction conical block.

Preferably, quick seal structure includes flat box, spring, pull ring, half arc closing plate and pull rod, collects the flat box that two symmetries of test tube lateral wall intermediate position fixed connection set up, collects the arc dead slot that test tube lateral wall intermediate position was equipped with two symmetries and sets up, the inside sliding connection half arc closing plate of arc dead slot, half arc closing plate lateral wall central point puts fixed connection pull rod, the other end of pull rod run through flat box lateral wall and with the inside sliding connection of flat box lateral wall, pull rod outer end fixed connection pull ring.

Preferably, the inside of the acid liquor storage pipe is provided with edible vinegar.

Preferably, the inner side wall of the semi-arc sealing plate is connected with a silica gel strip.

Compared with the related art, the sample collecting device for gene detection provided by the invention has the following beneficial effects:

the invention provides a sample collecting device for gene detection, which comprises the following components:

1. portable U-shaped pull rod, with the cystosepiment upwards proposing, the cystosepiment upwards proposing process when the bottom, touch the pressure-bearing flange and upwards rotate, thereby make the vertical setting of pressure-bearing flange, the stroke blocks the cystosepiment upwards proposing in-process not, thereby be convenient for whole cystosepiment proposition process, portable proposing the cystosepiment fast, conveniently control the cystosepiment and stack or take out the process, can make the inside cystosepiment increase of storing of collection bin, guarantee space utilization, hold a large amount of gene detection samples.

2. The nasal obstruction conical block is plugged into the nostril, and the nasal obstruction conical block can induce the salivary gland of the mouth to secrete a large amount of saliva by smelling vinegar easily, so that a large amount of gene detection samples can be collected quickly.

3. Two half arc closing plates dock sealedly fast, can reduce the outside air and sneak into the possibility, the biggest reduction outside air inflow to guarantee sample gene collection purity quality, reduce external factors and influence sample gene quality possibility.

4. Support whole collection bin and rise the take-up altitude, do not need the artifical operation of constantly bowing or squatting, the suitable height of regulation is operated in more convenient laborsaving, and through the locking universal wheel, people can drag the transportation.

Drawings

FIG. 1 is a schematic structural diagram of a sample collection device for gene detection according to a preferred embodiment of the present invention;

FIG. 2 is an enlarged view of a portion A of FIG. 1;

FIG. 3 is a schematic view of a portion of the enlarged structure shown at B in FIG. 1;

fig. 4 is a schematic sectional view of the quick seal structure and the collection tube shown in fig. 1 from the top.

Reference numbers in the figures: 1. collecting and storing a box; 2. covering the box; 3. a portable structure; 4. a tiered storage structure; 5. collecting the structure; 6. inducing a salivary structure; 7. a rapid sealing structure; 31. a hold-down bolt; 32. a chute; 33. a transverse plate; 34. a vertical plate; 35. locking the universal wheel; 36. a U-shaped rotating rod; 41. a U-shaped pull rod; 42. a foam board; 43. a storage tank; 44. a splint; 45. a pin shaft; 46. a pressure-bearing convex plate; 47. a notch; 48. a limiting rod; 51. a funnel cover; 52. a connecting belt; 53. a sealing plug; 54. collecting the test tubes; 61. a hose; 62. cushion blocks; 63. an acid liquor storage tube; 64. installing a plug; 65. a nose plug conical block; 71. a flat box; 72. a spring; 73. a pull ring; 74. a semi-arc shaped sealing plate; 75. a pull rod.

Detailed Description

The invention is further described with reference to the following figures and embodiments.

Please refer to fig. 1, fig. 2, fig. 3 and fig. 4 in combination, wherein fig. 1 is a schematic structural diagram of a sample collecting device for gene detection according to a preferred embodiment of the present invention; FIG. 2 is an enlarged view of a portion A of FIG. 1; FIG. 3 is a schematic view of a portion of the enlarged structure shown at B in FIG. 1; fig. 4 is a schematic sectional view of the quick seal structure and the collection tube shown in fig. 1 from the top. The gene detection sample collecting device comprises: collection storage box 1, portable structure 3, layered storage structure 4, collection structure 5, induced saliva structure 6 and quick seal structure 7.

In the specific implementation process, as shown in fig. 1 and 2, the top of the collection storage box 1 is open, the top of the collection storage box 1 is provided with a matched cover box 2, the cover box 2 is installed with the collection storage box 1 in a hasp manner, a layered storage structure 4 for storing more sample data is connected inside the collection storage box 1, the layered storage structure 4 comprises a U-shaped pull rod 41, foam plates 42, a clamping plate 44, a pin shaft 45, a pressure-bearing convex plate 46 and a limiting rod 48, a plurality of stacked foam plates 42 are arranged inside the collection storage box 1, the top surface of each foam plate 42 is provided with a plurality of storage grooves 43 uniformly arranged in quantity, the bottoms of two side walls of each foam plate 42 are respectively provided with a plurality of pressure-bearing convex plates 46, the positions of two side surfaces inside the collection storage box 1, which are close to the pressure-bearing convex plates 46, are respectively and fixedly connected with the clamping plate 44, and the clamping plate 44 is rotatably connected with the pressure-bearing convex plates 46 through the pin shaft 45, the top of the outer side wall of the pressure-bearing convex plate 46 is provided with a notch 47, the side surface of the bottom of the rotating end of the pressure-bearing convex plate 46 is connected with a limiting rod 48 which is obliquely arranged, the tops of the two side walls of the foam plate 42 are respectively and fixedly connected with a U-shaped pull rod 41, the collection structure 5 is adopted to collect saliva and then store the saliva, a single collection test tube 54 is inserted into a storage groove 43 on the foam plate 42 to be stored, the pressure-bearing convex plate 46 can be rotated and horizontally arranged through rotation, one end of the limiting rod 48 which is obliquely arranged is contacted with the inner side surface of the collection storage box 1, so that the pressure-bearing convex plate 46 can be horizontally arranged after being supported and rotated, the foam plate 42 is supported, a plurality of foam plates 42 are separated and arranged, the notch 47 can be attached to the bottom side surface of the foam plate 42, the possibility of shaking of the foam plate 42 is reduced, the attachment and the stability of the foam plate 42 is ensured, the U-shaped pull rod 41 is lifted by hand, foam board 42 when the bottom upwards provides the process, touches pressure-bearing flange 46 and upwards rotates to make the vertical setting of pressure-bearing flange 46, do not the stroke stops foam board 42 upwards provides the in-process, thereby be convenient for whole foam board 42 process of proposing, portable foam board 42 of proposing fast, conveniently control foam board 42 and stack or take out the process, can make and gather the inside foam board 42 increase of storing of bin 1, guarantee space utilization, hold more gene detection sample.

Referring to fig. 2, arc-shaped grooves matched with the limiting rods 48 are respectively formed in two side surfaces of the inside of the collecting and storing box 1, and the limiting rods 48 can be inserted into the arc-shaped grooves to contact with the arc-shaped grooves, so that the area of the convex points of the limiting rods 48 is increased, and the horizontal setting firmness of the pressure-bearing convex plate 46 is improved.

Referring to fig. 1 and 2, the portable structure 3 for moving and transferring is connected to the collecting storage box 1, the portable structure 3 includes a pressing bolt 31, a transverse plate 33, vertical plates 34, locking universal wheels 35 and U-shaped rotary rods 36, two parallel sliding grooves 32 are respectively arranged inside two side faces of the collecting storage box 1, the vertical plates 34 are slidably connected inside the sliding grooves 32, the bottom of each vertical plate 34 is connected with the locking universal wheel 35, the bottom ends of two adjacent vertical plates 34 are fixedly connected through the transverse plate 33, the two side faces of the bottom position of the collecting storage box 1 are in threaded connection with the pressing bolt 31, the top of the collecting storage box 1 is rotatably connected with the two symmetrically arranged U-shaped rotary rods 36, it is described that by loosening all the pressing bolts 31, the whole collecting storage box 1 is forcibly lifted, the length of the vertical plates 34 extending out of the outside can be increased, and the whole collecting storage box 1 is supported to be lifted to a certain height, do not need the artifical operation of constantly bowing or squatting, suitable height is adjusted in more convenient laborsaving operation, and through locking universal wheel 35, people can drag the transportation, and some stair topography shorten its riser 34 and stretch out outside length, adopt portable transportation.

Referring to fig. 1 and 2, a collection structure 5 for saliva is stored is connected in cystosepiment 42, collection structure 5 includes funnel cover 51, connecting band 52, sealing plug 53 and collects test tube 54, collect test tube 54 has been placed to the inside of holding vessel 43, collect test tube 54's top intercommunication funnel cover 51, collect test tube 54 top lateral wall and pass through connecting band 52 and connect sealing plug 53, sealing plug 53 and the mouth of pipe threaded connection who collects test tube 54, it should be said that, its sealing plug 53 is twisted out in the rotation, funnel cover 51 laminating mouth, spit saliva into and collect test tube 54 inside and store.

Referring to fig. 3, an induced saliva structure 6 for inducing a large amount of saliva to be secreted rapidly in the mouth is connected to the collecting structure 5, the induced saliva structure 6 includes a flexible tube 61, a cushion block 62, an acid storage tube 63, a mounting plug 64 and a nasal obstruction tapered block 65, the outer side wall of the top end of the collecting test tube 54 is fixedly connected with the acid storage tube 63, the mounting plug 64 is mounted at the top end of the acid storage tube 63, the top end of the mounting plug 64 is communicated with two symmetrically arranged flexible tubes 61, the outer side wall of the bottom end of the acid storage tube 63 is fixedly connected with two symmetrically arranged cushion blocks 62, the other end of the flexible tube 61 is fixedly connected with the nasal obstruction tapered block 65, the top of the cushion block 62 is provided with a tapered groove matched with the nasal obstruction tapered block 65, the tapered groove can allow the head of the unused nasal obstruction tapered block 65 to be placed and stored, so as to reduce infection caused by external dust accumulation, the interior of the nasal obstruction tapered block 65 is provided with a through hole communicated with the flexible tube 61, it is noted that, before spitting, the nasal obstruction conical block 65 is plugged into the nostril, and the vinegar is easily smelled to induce the salivary gland of the mouth to secrete a large amount of saliva, so that a large amount of gene detection samples can be collected quickly.

Referring to fig. 3 and 4, a rapid sealing structure 7 for reducing the mixing amount of the outside air and the collected saliva is connected to the collecting structure 5, the rapid sealing structure 7 comprises a flat box 71, a spring 72, a pull ring 73, a semi-arc sealing plate 74 and a pull rod 75, two symmetrically arranged flat boxes 71 are fixedly connected to the middle position of the outer side wall of the collecting tube 54, two symmetrically arranged arc-shaped empty slots are arranged at the middle position of the outer side wall of the collecting tube 54, the semi-arc sealing plate 74 is slidably connected to the inside of the arc-shaped empty slots, the pull rod 75 is fixedly connected to the center position of the outer side wall of the semi-arc sealing plate 74, the other end of the pull rod 75 penetrates through the side wall of the flat box 71 and is slidably connected to the inside of the side wall of the flat box 71, the pull ring 73 is fixedly connected to the outer end of the pull rod 75, it should be noted that the saliva is loaded into the inside of the collecting tube 54, and inserted into the two pull rings 73 by thumb fingers to pull the two pull rings 73, thereby drive two half arc sealings plates 74 separation, can let saliva flow in to collect test tube 54's interior bottom, through loosening two pull rings 73, receive spring 72 rebound force effect, two half arc sealings plates 74 dock sealed fast, can reduce the outside air and mix into the possibility, the maximum reduction outside air inflow to guarantee sample gene collection purity quality, reduce the influence sample gene quality possibility of external factors.

The inside of the acid liquor storage pipe 63 is provided with edible vinegar which is nontoxic and ensures the inhalation health.

The silica gel strip is connected to the inside wall of half arc closing plate 74, can have elasticity by two half arc closing plate 74 contact lateral walls for seam leakproofness increases.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. A sample collection device for gene detection, comprising:

the device comprises a collection storage box (1), wherein the top of the collection storage box (1) is open, and a matched cover box (2) is installed at the top of the collection storage box (1);

the portable structure (3) is used for moving and transferring, and the portable structure (3) is connected to the collection storage box (1);

the layered storage structure (4) is used for storing more sample plate data, the layered storage structure (4) is connected inside the collection storage box (1), the layered storage structure (4) comprises a U-shaped pull rod (41), foam plates (42), clamping plates (44), a pin shaft (45), pressure-bearing convex plates (46) and a limiting rod (48), a plurality of stacked foam plates (42) are arranged inside the collection storage box (1), a plurality of storage grooves (43) which are uniformly arranged in quantity are formed in the top surface of each foam plate (42), a plurality of pressure-bearing convex plates (46) are respectively arranged at the bottoms of the two side walls of each foam plate (42), the clamping plates (44) are respectively and fixedly connected at the positions, close to the pressure-bearing convex plates (46), of the two side surfaces inside the collection storage box (1), the clamping plates (44) are rotatably connected with the pressure-bearing convex plates (46) through the pin shaft (45), gaps (47) are formed in the tops of the outer side walls of the pressure-bearing convex plates (46), the side surface of the bottom of the rotating end of the pressure-bearing convex plate (46) is connected with a limiting rod (48) which is obliquely arranged, and the tops of two side walls of the foam plate (42) are respectively and fixedly connected with a U-shaped pull rod (41);

a collecting structure (5), the collecting structure (5) for saliva storage being connected to the foam plate (42);

an induced saliva structure (6), the induced saliva structure (6) for inducing rapid secretion of a large amount of saliva in the mouth being connected to the collecting structure (5);

the quick sealing structure (7) is used for reducing the mixing amount of the outside air and the collected saliva, and the quick sealing structure (7) is connected to the collecting structure (5).

2. The gene detection sample collection device according to claim 1, wherein the collection storage box (1) is provided with arc-shaped grooves matched with the limiting rods (48) on two side surfaces inside.

3. The gene detection sample collecting device according to claim 1, wherein the portable structure (3) comprises a compression bolt (31), a transverse plate (33), a vertical plate (34), a locking universal wheel (35) and a U-shaped rotating rod (36), two sliding grooves (32) which are arranged in parallel are respectively arranged inside two side faces of the collecting storage box (1), the sliding connection vertical plate (34) inside the sliding grooves (32), the locking universal wheel (35) is connected to the bottom of the vertical plate (34), the bottom ends of two adjacent vertical plates (34) are fixedly connected through the transverse plate (33), the compression bolt (31) is connected to two side faces of the bottom position of the collecting storage box (1) in a threaded manner, and the U-shaped rotating rod (36) which is symmetrically arranged is rotatably connected to the top of the collecting storage box (1).

4. The gene detection sample collection device according to claim 1, wherein the collection structure (5) comprises a funnel cover (51), a connecting belt (52), a sealing plug (53) and a collection test tube (54), the collection test tube (54) is placed in the storage tank (43), the top end of the collection test tube (54) is communicated with the funnel cover (51), the outer side wall of the top end of the collection test tube (54) is connected with the sealing plug (53) through the connecting belt (52), and the sealing plug (53) is in threaded connection with the pipe opening of the collection test tube (54).

5. The gene detection sample collection device according to claim 4, wherein the induced saliva structure (6) comprises a hose (61), a cushion block (62), an acid storage tube (63), a mounting plug (64) and a nasal obstruction conical block (65), the outer side wall of the top end of the collection test tube (54) is fixedly connected with the acid storage tube (63), the mounting plug (64) is mounted at the top end of the acid storage tube (63), the top end of the mounting plug (64) is communicated with the two symmetrically arranged hoses (61), the outer side wall of the bottom end of the acid storage tube (63) is fixedly connected with the two symmetrically arranged cushion blocks (62), the other end of the hose (61) is fixedly connected with the nasal obstruction conical block (65), the tops of the cushion blocks (62) are provided with conical grooves matched with the nasal obstruction conical block (65), and the interior of the nasal obstruction conical block (65) is provided with through holes communicated with the hoses (61).

6. The gene detection sample collecting device according to claim 5, wherein the quick sealing structure (7) comprises a flat box (71), a spring (72), a pull ring (73), a semi-arc sealing plate (74) and a pull rod (75), the middle position of the outer side wall of the collection test tube (54) is fixedly connected with the two symmetrically arranged flat boxes (71), the middle position of the outer side wall of the collection test tube (54) is provided with two symmetrically arranged arc empty grooves, the inner part of each arc empty groove is slidably connected with the semi-arc sealing plate (74), the center position of the outer side wall of the semi-arc sealing plate (74) is fixedly connected with the pull rod (75), the other end of the pull rod (75) penetrates through the side wall of the flat box (71) and is slidably connected with the inner part of the side wall of the flat box (71), and the outer end of the pull rod (75) is fixedly connected with the pull ring (73).

7. The device for collecting a sample for gene testing according to claim 6, wherein edible vinegar is disposed inside the acid storage tube (63).

8. The gene detection sample collection device according to claim 7, wherein the inner side wall of the semi-arc sealing plate (74) is connected with a silicone strip.