CN113797216A - 一种甘草酸二铵的应用 - Google Patents

一种甘草酸二铵的应用 Download PDF

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CN113797216A
CN113797216A CN202111280361.2A CN202111280361A CN113797216A CN 113797216 A CN113797216 A CN 113797216A CN 202111280361 A CN202111280361 A CN 202111280361A CN 113797216 A CN113797216 A CN 113797216A
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diammonium glycyrrhizinate
hypotension
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blood pressure
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韩乾国
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Chengdu Fifth People's Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

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Abstract

本发明属于药物技术领域，具体涉及一种甘草酸二铵的应用。采用甘草酸二铵作为治疗慢性低血压的药物。本发明采用甘草酸二铵治疗慢性低血压，可有效提高患者血压，并且无皮质激素的不良反应，长期服用耐受性良好，反馈性抑制肾上腺功能作用较小，故作用稳定。

Description

一种甘草酸二铵的应用
技术领域
本发明属于药物技术领域，具体涉及一种甘草酸二铵的应用。
背景技术
一般成年人收缩压低于90mmHg，舒张压低于60mmHg，称为低血压。低血压可分为急性低血压、慢性低血压和体位性低血压。慢性低血压属生理性，与个人体质、家庭遗传等有关，如遇诱发因素时，血压快速降低，放生血管舒缩障碍产生晕厥，晕厥多见于年轻体弱女性，发作常有明显诱因(如劳累、情绪紧张、恐惧等)，在天气闷热、空气污浊、疲劳、失眠等情况下更易发生。晕厥时可有上腹部不适、恶心、面色苍白、肢体发软，甚至出现短暂的意识丧失，常伴有明显的血压下降、手脚湿冷、脉搏细弱、尿量减少等，其发生机制是由于各种刺激迷走神经反射，引起短暂的血管床扩张。呈慢性状态者，发病年龄以18～35岁之间的女性居多，城市多于农村，其发病原因多与家族遗传因素密切相关。血压处在90/60mmHg时多无临床症状，当血压持续低于90/50mmHg或血压突然下降时大多数会出现头晕、乏力等临床表现，由于其症状发作过后即较快自然恢复，故难以判断其原因，因此不像高血压病那样因发病率高，危害大，临床症状明显成为大家关注的焦点，所以目前低血压尚无具体治疗方案，甚至被人们忽视。当低血压患者经常出现头晕、乏力以及晕厥时，影响到生活和工作，造成患者产生焦虑不安。目前西医治疗一般采用增加营养饮食，注意休息，补充能量，甚至个别男性以长期饮高度白酒作为试验治疗手段，收效甚微，治标不治本，效果不理想。
发明内容
本发明公开了一种甘草酸二铵的应用，拟解决背景技术中提到的目前低血压的治疗方式收效甚微，治标不治本，效果不理想的问题。
为解决上述技术问题，本发明采用的技术方案如下：
一种甘草酸二铵的应用，采用甘草酸二铵作为治疗慢性低血压的药物。
下面通过治疗数据对本发明的效果做进一步的说明：
患者：吴某；年龄：48；治疗前的收缩压为：86.4；舒张压为：54.5；
口服甘草酸二铵进行治疗后：服用一周后收缩压为99.7；舒张压为：58.9；
服用一个月后：收缩压为120.8；舒张压为：65.2；
服用三个月后：收缩压为118.6；舒张压为：63.4；
由上述可知，本发明在临床上治疗低血压已经取得了较好的效果。
综上所述，由于采用了上述技术方案，本发明的有益效果是：本发明采用甘草酸二铵作为口服升压药物，对于慢性低血压有明显的治疗效果，可有效提高患者血压，并且无皮质激素的不良反应，长期服用耐受性良好，反馈性抑制肾上腺功能作用较小，故作用稳定。
具体实施方式
下面对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅是本申请一部分实施例，而不是全部的实施例。因此，以下对本申请的实施例的详细描述并非旨在限制要求保护的本申请的范围，而是仅仅表示本申请的选定实施例。基于本申请的实施例，本领域技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例，都属于本申请保护的范围。
一种甘草酸二铵的应用，采用甘草酸二铵作为治疗慢性低血压的药物。
下面通过治疗数据对本发明的效果做进一步的说明：
患者：吴某；年龄：48；治疗前的收缩压为：86.4；舒张压为：54.5；
口服甘草酸二铵进行治疗后：服用一周后收缩压为99.7；舒张压为：58.9；
服用一个月后：收缩压为120.8；舒张压为：65.2；
服用三个月后：收缩压为118.6；舒张压为：63.4；
本发明采用甘草酸二铵作为口服升压药物，对于慢性低血压有明显的治疗效果，可有效提高患者血压，并且无皮质激素的不良反应，长期服用耐受性良好，反馈性抑制肾上腺功能作用较小，故作用稳定。
以上所述实施例仅表达了本申请的具体实施方式，其描述较为具体和详细，但并不能因此而理解为对本申请保护范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本申请技术方案构思的前提下，还可以做出若干变形和改进，这些都属于本申请的保护范围。

Claims (1)

1.一种甘草酸二铵的应用，其特征在于，采用甘草酸二铵作为治疗慢性低血压的药物。
CN202111280361.2A 2021-10-29 2021-10-29 一种甘草酸二铵的应用 Pending CN113797216A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11147825A (ja) * 1997-11-13 1999-06-02 Lion Corp 粘膜吸収性の向上方法及び粘膜外用剤
CN101987081A (zh) * 2010-07-16 2011-03-23 钟术光 一种控释制剂
CN111228281A (zh) * 2020-03-06 2020-06-05 贵州神奇药业有限公司 甘草酸二铵的新用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11147825A (ja) * 1997-11-13 1999-06-02 Lion Corp 粘膜吸収性の向上方法及び粘膜外用剤
CN101987081A (zh) * 2010-07-16 2011-03-23 钟术光 一种控释制剂
CN111228281A (zh) * 2020-03-06 2020-06-05 贵州神奇药业有限公司 甘草酸二铵的新用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
韩乾国，等: "甘草酸二铵治疗慢性低血压", 中华高血压杂志, vol. 21, no. 4, pages 381 - 384 *

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