CN113770093A

CN113770093A - Cleaning device of liquid chromatograph

Info

Publication number: CN113770093A
Application number: CN202110971682.0A
Authority: CN
Inventors: 章志尧; 刘丽丽
Original assignee: Jiangsu Tongji Analytical Instrument Co ltd
Current assignee: Jiangsu Tongji Analytical Instrument Co ltd
Priority date: 2021-08-24
Filing date: 2021-08-24
Publication date: 2021-12-10
Anticipated expiration: 2041-08-24
Also published as: CN113770093B

Abstract

The invention provides a cleaning device of a liquid chromatograph, which comprises a box body, wherein the inner side of the box body is slidably connected with a moving mechanism, the moving mechanism comprises a displacement chute formed in the inner side of the box body, a displacement seat is slidably connected in the displacement chute, the top end of the displacement seat is fixedly provided with a moving round rod, the inner side of the displacement seat is slidably connected with a lifting processing box, two ends of the lifting processing box are fixedly provided with electric telescopic rods, and the fixed end of each electric telescopic rod is fixedly connected with the inner side of the displacement seat, and the cleaning device has the beneficial effects that: through the slip of the removal seat in the box inside that sets up to make holistic lift handle the case and can follow the inside shifting out of box, thereby can wash the processing to the different functional position of liquid chromatograph, and the electric telescopic handle that just passes through to set up drives the lift of lift processing case, make holistic belt cleaning device more can use in the cleaning of different liquid chromatographs, improved whole belt cleaning device's application range.

Description

Cleaning device of liquid chromatograph

Technical Field

The invention belongs to the technical field of liquid chromatographs, and particularly relates to a cleaning device of a liquid chromatograph.

Background

Liquid chromatographs are also classified into liquid-liquid chromatography (LLC) and liquid-solid chromatography (LSC) according to whether the stationary phase is liquid or solid. The modern liquid chromatograph consists of a high-pressure infusion pump, a sample introduction system, a temperature control system, a chromatographic column, a detector, a signal recording system and the like. Compared with a classical liquid phase column chromatography device, the device has the characteristics of high efficiency, rapidness, sensitivity and the like, when a liquid chromatograph is cleaned, a pump must be flushed by clear water for 15 minutes after salt-containing buffer solution is used, at the moment, a discharge valve must be opened, waste liquid cannot enter a chromatographic column, the discharge valve is closed again, the whole system is flushed by 90% + 10% water and methanol solution, the time is 15-20 minutes, and the flow is 1 m/min. The method mainly comprises the steps of washing other parts containing salt in the system, and then washing the whole system by using a pure strong solvent for 1 hour at a flow rate of 1 m/min. The step is mainly to protect the chromatographic column, if no buffer solution is used, the

steps

1 and 2 can be omitted, and the whole system is directly washed by a pure strong solvent for 1 hour at the flow rate of 1 m/min. The prior cleaning device mainly has the following common defects:

in traditional belt cleaning device, because each part of liquid chromatograph all is in different positions to cause the difficulty to unified washing, and can produce a large amount of toxic gases after opening liquid chromatograph, just improved the degree of difficulty to liquid chromatograph's washing, then caused the reduction of liquid chromatograph cleaning performance and the increase of the degree of difficulty.

Disclosure of Invention

The invention aims to provide a cleaning device of a liquid chromatograph, and aims to solve the problems that in the prior art, because each part of the liquid chromatograph is in different positions, uniform cleaning is difficult, and after the liquid chromatograph is opened, a large amount of toxic gas is generated, so that the difficulty in cleaning the liquid chromatograph is increased, and the cleaning effect of the liquid chromatograph is reduced and the difficulty is increased.

In order to achieve the purpose, the invention provides the following technical scheme:

a cleaning device of a liquid chromatograph comprises a box body, wherein the inner side of the box body is connected with a moving mechanism in a sliding manner, and the inner side of the box body is respectively provided with a suction mechanism, a cleaning mechanism and a drying mechanism;

the moving mechanism comprises a displacement sliding groove which is formed in the inner side of the box body, a displacement seat is connected to the inside of the displacement sliding groove in a sliding mode, a moving round rod is fixedly mounted at the top end of the displacement seat, a lifting treatment box is connected to the inner side of the displacement seat in a sliding mode, electric telescopic rods are fixedly mounted at the two ends of the lifting treatment box, and the fixed ends of the electric telescopic rods are fixedly connected with the inner side of the displacement seat.

Preferably, the suction mechanism comprises a suction box fixedly mounted in the box body, the suction box is respectively provided with a collecting tank and a placing tank, one side of the bottom of the collecting tank is provided with a discharge port, one side of the top of the collecting tank is fixedly provided with a feed inlet, the placing tank is internally and fixedly provided with a suction pump, the feed inlet is internally and fixedly hinged with an isolation cover plate through a movable hinge, a suction pipeline is fixedly mounted at the feed inlet of the suction pump, a suction disc is fixedly mounted at the feed inlet of the suction pipeline, and the discharge port of the suction pump is communicated with the inner side of the collecting tank.

Preferably, the suction mechanism further comprises a feeding box sleeved outside the feeding port, a water level line is fixedly installed on one side of the feeding box, a discharging cover plate is connected to the bottom of the feeding box in a sliding mode through an opening, a pulling rod is fixedly installed on one side of the discharging cover plate, a pull ring is fixedly installed at one end of the pulling rod, and the outer side of the pulling rod is connected with the inner side of the feeding box in an inserting mode.

Preferably, the cleaning mechanism comprises a cleaning box fixedly mounted on the top of the suction box, a first cleaning tank and two second cleaning tanks are arranged in the cleaning box, the tops of the first cleaning tank and the second cleaning tank are connected with a first pressing plate and a second pressing plate in a sliding manner, springs are fixedly mounted on the tops of the first pressing plate and the second pressing plate, the top of the first cleaning tank is communicated with the top of the second cleaning tank, a branch cleaning pipeline is fixedly mounted on one side of the cleaning box, and a cleaning spray head is fixedly mounted at a water outlet of the branch cleaning pipeline.

Preferably, the drying mechanism comprises a drying box fixedly mounted at the top of the cleaning box, an air inlet groove and a heating groove are respectively formed in the inner side of the drying box, an air pump is fixedly mounted inside the air inlet groove, an air inlet is fixedly mounted on one side of the top of the air inlet groove, an air outlet of the air pump is respectively communicated with the heating groove and the top of the second cleaning groove, a heating guide wire is fixedly mounted on the inner side of the heating groove, a drying pipeline is fixedly mounted on one side of the heating groove, and a drying head is fixedly mounted at one end of the drying pipeline.

Preferably, the inner side of the lifting treatment box is movably connected with the outer sides of the suction pipeline, the branch cleaning pipeline and the drying pipeline, the outer sides of the suction pipeline, the branch cleaning pipeline and the drying pipeline are movably connected with a plurality of buckles, and one ends of the plurality of buckles are fixedly connected with the inner side of the lifting treatment box.

Preferably, the top of the box body is provided with a strip-shaped groove, the inside of the strip-shaped groove is connected with a sliding frame in a sliding manner, and the inner side of the sliding frame is connected with the outer sides of the suction pipeline, the branch cleaning pipeline and the drying pipeline in a penetrating manner.

Preferably, a switch panel is fixedly mounted on one side of the box body, an electric telescopic rod switch, an absorption pump switch, an air pump switch and a heating guide wire switch are fixedly mounted on the surface of the switch panel, and the electric telescopic rod, the absorption pump, the air pump and the heating guide wire are respectively and electrically connected with an external power supply through the electric telescopic rod switch, the absorption pump switch, the air pump switch and the heating guide wire switch.

Compared with the prior art, the invention has the beneficial effects that:

1) through the slip of the removal seat in the box inside that sets up to make holistic lift handle the case and can follow the inside shifting out of box, thereby can wash the processing to the different functional position of liquid chromatograph, and the electric telescopic handle that just passes through to set up drives the lift of lift processing case, make holistic belt cleaning device more can use in the cleaning of different liquid chromatographs, improved whole belt cleaning device's application range.

2) Through the suction pump that sets up and the effect of absorption pipeline to probably there is toxic gas to absorb after opening liquid chromatograph, thereby play the effect of protection to operating personnel, and thereby it handles to magazines such as the inside gas that absorbs of collecting vat more to be convenient for through the charging box that sets up and charge door, has reduced the harm that gas emission caused environment and human body then.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the overall structure of the present invention;

FIG. 3 is a schematic view of the internal structure of the case according to the present invention;

FIG. 4 is a schematic view of the lift cage of the present invention;

FIG. 5 is a schematic view of the internal structure of the cleaning mechanism of the present invention;

FIG. 6 is a schematic view of the internal structure of the drying box according to the present invention;

fig. 7 is a schematic view of the internal structure of the drying mechanism of the present invention.

In the figure: 1. a box body; 2. a moving mechanism; 21. a displacement chute; 22. a displacement seat; 23. moving the round bar; 24. lifting the treatment box; 25. an electric telescopic rod; 3. a suction mechanism; 31. an absorption box; 32. collecting tank; 33. a placement groove; 34. an outlet port; 35. a feed inlet; 36. a suction pump; 37. an isolation cover plate; 38. a suction pipeline; 39. a suction cup; 310. a feed box; 311. a water line; 312. a discharge cover plate; 313. pulling a rod; 314. a pull ring; 4. a cleaning mechanism; 41. a cleaning tank; 42. a first cleaning tank; 43. a second cleaning tank; 44. a first platen; 45. a second platen; 46. a spring; 47. branch cleaning pipeline; 48. cleaning the spray head; 5. a drying mechanism; 51. a drying box; 52. an air inlet groove; 53. a heating tank; 54. an air pump; 55. an air inlet; 56. heating the guide wire; 57. drying the pipeline; 58. a drying head; 6. buckling; 7. a strip-shaped groove; 8. and a sliding frame.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-7, the present invention provides the following technical solutions: a cleaning device of a liquid chromatograph comprises a box body 1, wherein the inner side of the box body 1 is connected with a moving mechanism 2 in a sliding manner, and the inner side of the box body 1 is respectively provided with a suction mechanism 3, a cleaning mechanism 4 and a drying mechanism 5;

moving mechanism 2 includes the displacement spout 21 of seting up with box 1 inboard, and the inside sliding connection of displacement spout 21 has displacement seat 22, and the top fixed mounting of displacement seat 22 has removal round bar 23, and the inboard sliding connection of displacement seat 22 has lift processing case 24, and the equal fixed mounting in both ends of lift processing case 24 has electric telescopic handle 25, and electric telescopic handle 25 stiff end and the inboard fixed connection of displacement seat 22.

When the cleaning device is used for cleaning the liquid chromatograph, firstly, the liquid chromatograph can be opened through the cleaning device, so that the lifting treatment box 24 is moved to a proper position through the moving mechanism 2, impurities such as harmful gas possibly existing in the liquid chromatograph are absorbed through the absorbing mechanism 3, then, different solutions are cleaned in the liquid chromatograph through the cleaning mechanism 4, the cleaning position in the liquid chromatograph is dried through the drying mechanism 5, when the liquid chromatograph needs to be cleaned, the movable round rod 23 can be pulled to slide in the displacement chute 21, so that the movable round rod 23 can drive the displacement seat 22 to move, the lifting treatment box 24 can slide out of the box body 1, when the displacement seat 22 is moved to a proper position, the telescopic rod 25 can drive the lifting treatment box 24 to lift and slide, so that the lifting processing box 24 can be moved to the position to be processed by the liquid chromatograph, and the cleaning of the liquid chromatograph is more convenient.

Preferably, suction means 3 includes the case 31 of absorbing with the inside fixed mounting of box 1, collecting vat 32 and standing groove 33 have been seted up respectively to the inside of absorbing case 31, discharge port 34 has been seted up to bottom one side of collecting vat 32, top one side fixed mounting of collecting vat 32 has charge door 35, the inside fixed mounting of standing groove 33 has suction pump 36, the inside of charge door 35 articulates through the activity hinge has isolation cover 37, suction pump 36's feed inlet fixed mounting has suction pipeline 38, suction pipeline 38's feed inlet fixed mounting has sucking disc 39, suction pump 36's discharge gate communicates with each other with the inboard of collecting vat 32.

In specific use, after the lifting treatment box 24 is moved to a proper position, the position of the liquid chromatograph needing to be cleaned can be opened, so that the harmful gas possibly existing in the liquid chromatograph is sucked by the suction pipe 38 and the suction cup 39 through the suction pump 36 in the placing tank 33, and after the gas is sucked into the suction pump 36 and discharged into the collecting tank 32, the processed medicament can be added into the charging box 310 through the charging port 35, after the medicine is put into the charging opening 35, the medicine rotates the isolation cover 37 inwards due to gravity, so that the medicine can enter the charging box 310, and after the medicament enters the feed box 310, the isolation cover plate 37 plays the role of isolating the feed opening 35, after the gas is treated with the agent, the gas and other impurities are less harmful to the human body and the environment, and can be discharged through the discharge port 34.

Preferably, the suction mechanism 3 further comprises a feed box 310 sleeved outside the feed port 35, a water level line 311 is fixedly mounted on one side of the feed box 310, a discharge cover plate 312 is slidably connected to the bottom of the feed box 310 through an opening, a pulling rod 313 is fixedly mounted on one side of the discharge cover plate 312, a pulling ring 314 is fixedly mounted at one end of the pulling rod 313, and the outside of the pulling rod 313 is inserted and connected with the inside of the feed box 310.

During the specific use, add the inside back of filling box 310 with the medicament through charge door 35, accessible water line 311 looks over the inside medicament volume of adding of filling box 310, when water line 311 reachd suitable position, alright pulling pull ring 314, make pull ring 314 can be through the connection of pulling pole 313, thereby drive ejection of compact apron 312 and remove, make the inside medicament of filling box 310 can get into inside the collecting vat 32, thereby handle the inside gas and other impurity of collecting vat 32, the safety impact that liquid chromatograph caused operating personnel has been reduced.

Preferably, the cleaning mechanism 4 includes a cleaning box 41 fixedly mounted on the top of the suction box 31, a first cleaning tank 42 and two second cleaning tanks 43 are disposed inside the cleaning box 41, the top of the first cleaning tank 42 and the top of the second cleaning tank 43 are slidably connected with a first pressing plate 44 and a second pressing plate 45, springs 46 are fixedly mounted on the tops of the first pressing plate 44 and the second pressing plate 45, the top of the first cleaning tank 42 is communicated with the top of the second cleaning tank 43, a branch cleaning pipeline 47 is fixedly mounted on one side of the cleaning box 41, and a cleaning spray head 48 is fixedly mounted on a water outlet of the branch cleaning pipeline 47.

When the device is used specifically, after harmful substances in the liquid chromatograph are sucked, the liquid chromatograph can be continuously cleaned to different degrees through the liquid in the first cleaning tank 42 and the other two second cleaning tanks 43, the liquid in the first cleaning tank 42 and the other two second cleaning tanks 43 can be cleaned at intervals through the branch cleaning pipeline 47 and the cleaning nozzle 48, and when the liquid in the first cleaning tank 42 and the other two second cleaning tanks 43 is not easy to spray out from the cleaning nozzle 48, the air can be discharged into the positions of the first pressing plate 44 and the second pressing plate 45 at the tops of the first cleaning tank 42 and the other two second cleaning tanks 43 through the action of the air pump 54, so that the first pressing plate 44 and the second pressing plate 45 can perform a pressure action on the liquid in the first cleaning tank 42 and the second cleaning tanks 43 through the pressure action of the air, thereby improving the cleaning effect of the whole cleaning device, at the same time, the spring 46 also acts as a fixing for the first and

second pressure plates

44, 45.

Preferably, the drying mechanism 5 includes a drying box 51 fixedly mounted on the top of the cleaning box 41, an air inlet 52 and a heating tank 53 are respectively formed in the inner side of the drying box 51, an air pump 54 is fixedly mounted in the air inlet 52, an air inlet 55 is fixedly mounted on one side of the top of the air inlet 52, an air outlet of the air pump 54 is respectively communicated with the tops of the heating tank 53 and the second cleaning tank 43, a heating guide wire 56 is fixedly mounted on the inner side of the heating tank 53, a drying pipeline 57 is fixedly mounted on one side of the heating tank 53, and a drying head 58 is fixedly mounted on one end of the drying pipeline 57.

During the specific use, after the inside washing of liquid chromatograph is accomplished, air inlet duct 52 is through inside air inlet 55 inhales the air inlet duct 52 with the outside air to through the effect of air pump 54, make inside gas is sent into heating tank 53, and heat the air that gets into through heating seal wire 56, the air after rethread stoving pipeline 57 and stoving head 58 will heat is discharged, thereby plays the effect of drying to liquid chromatograph inside.

Preferably, the inner side of the lifting treatment box 24 is movably connected with the outer sides of the suction pipeline 38, the branch cleaning pipeline 47 and the drying pipeline 57, the outer sides of the suction pipeline 38, the branch cleaning pipeline 47 and the drying pipeline 57 are movably connected with a plurality of buckles 6, and one ends of the buckles 6 are fixedly connected with the inner side of the lifting treatment box 24.

During specific use, buckle 6 has played fixed effect to suction line 38, branch's washing pipeline 47 and stoving pipeline 57 for it can be fixed inside lift processing case 24, thereby can follow lift processing case 24 and remove, has improved holistic result of use.

Preferably, the top of box 1 has seted up bar groove 7, and the inside sliding connection in bar groove 7 has sliding frame 8, and sliding frame 8's inboard and suction duct 38, branch wash the outside of pipeline 47 and stoving pipeline 57 alternate the connection.

During the specific use, at the in-process that lift processing case 24 removed from the box 1 is inside, sliding frame 8 slides in the box 1 through bar groove 7 to drive and absorb pipeline 38, branch's washing pipeline 47 and stoving pipeline 57, make it can be more convenient for lift processing case 24 the removal and operation such as wash.

Preferably, one side fixed mounting of box 1 has flush mounting plate of switch, flush mounting plate of switch's surface fixed mounting have electric telescopic handle switch, absorb pump switch, air pump switch and heating seal wire switch, and electric telescopic handle 25, absorption pump 36, air pump 54 and heating seal wire 56 are respectively through electric telescopic handle switch, absorption pump switch, air pump switch and heating seal wire switch and external power supply electric connection.

During the concrete use, the equipment switch through the setting on the flush mounting plate of switch is convenient for control liquid chromatograph's belt cleaning device.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The cleaning device of the liquid chromatograph comprises a box body (1), and is characterized in that the inner side of the box body (1) is connected with a moving mechanism (2) in a sliding manner, and the inner side of the box body (1) is respectively provided with a suction mechanism (3), a cleaning mechanism (4) and a drying mechanism (5);

moving mechanism (2) include displacement spout (21) of seting up with box (1) inboard, the inside sliding connection of displacement spout (21) has displacement seat (22), the top fixed mounting of displacement seat (22) has removal round bar (23), the inboard sliding connection of displacement seat (22) has lift to handle case (24), the equal fixed mounting in both ends of lift processing case (24) has electric telescopic handle (25), the inboard fixed connection of electric telescopic handle (25) stiff end and displacement seat (22).

2. The cleaning apparatus for a liquid chromatograph according to claim 1, wherein: suction means (3) include with box (1) inside fixed mounting's absorption case (31), collecting vat (32) and standing groove (33) have been seted up respectively to the inside of absorption case (31), discharge port (34) have been seted up to bottom one side of collecting vat (32), top one side fixed mounting of collecting vat (32) has charge door (35), the inside fixed mounting of standing groove (33) has suction pump (36), the inside of charge door (35) articulates through the activity hinge has isolation cover board (37), the feed inlet fixed mounting of suction pump (36) has suction pipe (38), the feed inlet fixed mounting of suction pipe (38) has sucking disc (39), the discharge gate of suction pump (36) communicates with the inboard of collecting vat (32) each other.

3. The cleaning apparatus for a liquid chromatograph according to claim 2, wherein: suction means (3) still include with charge door (35) outside cover feed box (310) of establishing, one side fixed mounting of feed box (310) has water line (311), there is ejection of compact apron (312) bottom of feed box (310) through trompil sliding connection, one side fixed mounting of ejection of compact apron (312) has pulling rod (313), the one end fixed mounting of pulling rod (313) has pull ring (314), the outside of pulling rod (313) alternates with the inboard of feed box (310) and is connected.

4. The cleaning apparatus for a liquid chromatograph according to claim 3, wherein: cleaning mechanism (4) include with absorb case (31) top fixed mounting's washing case (41), first washing tank (42) and two second washing tanks (43) have been seted up to the inside of washing case (41), the top sliding connection of first washing tank (42) and second washing tank (43) has first clamp plate (44) and second clamp plate (45), the top fixed mounting of first clamp plate (44) and second clamp plate (45) has spring (46), the top of first washing tank (42) and the top of second washing tank (43) communicate each other, one side fixed mounting of washing case (41) has branch washing pipeline (47), the delivery port fixed mounting of branch washing pipeline (47) has washing shower nozzle (48).

5. The cleaning apparatus for a liquid chromatograph according to claim 4, wherein: drying mechanism (5) include with wash case (41) top fixed mounting's stoving case (51), air inlet tank (52) and heating tank (53) have been seted up respectively to the inboard of stoving case (51), the inside fixed mounting of air inlet tank (52) has air pump (54), top one side fixed mounting of air inlet tank (52) has air inlet (55), the gas outlet of air pump (54) communicates with the top of heating tank (53) and second washing tank (43) each other respectively, the inboard fixed mounting of heating tank (53) has heating seal wire (56), one side fixed mounting of heating tank (53) has stoving pipeline (57), the one end fixed mounting of stoving pipeline (57) has stoving head (58).

6. The cleaning apparatus for a liquid chromatograph according to claim 1, wherein: the inboard of case (24) is handled with the outside swing joint who absorbs pipeline (38), branch and wash pipeline (47) and stoving pipeline (57), the outside swing joint who absorbs pipeline (38), branch and wash pipeline (47) and stoving pipeline (57) has a plurality of buckle (6), a plurality of the inboard fixed connection of the one end of buckle (6) and lift processing case (24).

7. The cleaning apparatus for a liquid chromatograph according to claim 1, wherein: a strip-shaped groove (7) is formed in the top of the box body (1), a sliding frame (8) is connected to the inside of the strip-shaped groove (7) in a sliding mode, and the inner side of the sliding frame (8) is connected with the outer sides of the suction pipeline (38), the branch cleaning pipeline (47) and the drying pipeline (57) in a penetrating mode.

8. The cleaning apparatus for a liquid chromatograph according to claim 5, wherein: one side fixed mounting of box (1) has flush mounting plate of switch, flush mounting plate of switch's fixed surface installs electric telescopic handle switch, absorbs pump switch, air pump switch and heating seal wire switch, electric telescopic handle (25), absorption pump (36), air pump (54) and heating seal wire (56) are respectively through electric telescopic handle switch, absorption pump switch, air pump switch and heating seal wire switch and external power supply electric connection.