CN113768597A - Vertebral pedicle screw capable of promoting bone regeneration based on degradable hydrogel rich in exosome - Google Patents
Vertebral pedicle screw capable of promoting bone regeneration based on degradable hydrogel rich in exosome Download PDFInfo
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- CN113768597A CN113768597A CN202111081941.9A CN202111081941A CN113768597A CN 113768597 A CN113768597 A CN 113768597A CN 202111081941 A CN202111081941 A CN 202111081941A CN 113768597 A CN113768597 A CN 113768597A
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- nail body
- exosome
- nail
- rich
- pedicle screw
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- 210000001808 exosome Anatomy 0.000 title claims abstract description 30
- 239000000017 hydrogel Substances 0.000 title claims abstract description 27
- 230000010478 bone regeneration Effects 0.000 title claims abstract description 16
- 230000001737 promoting effect Effects 0.000 title claims abstract description 15
- 230000003014 reinforcing effect Effects 0.000 claims abstract description 10
- 230000007246 mechanism Effects 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims description 15
- 238000012856 packing Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 11
- 230000011164 ossification Effects 0.000 abstract description 7
- 230000004663 cell proliferation Effects 0.000 abstract description 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 abstract description 4
- 210000001185 bone marrow Anatomy 0.000 abstract description 3
- 230000008569 process Effects 0.000 description 7
- 208000001132 Osteoporosis Diseases 0.000 description 5
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000002639 bone cement Substances 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 description 1
- 241001079814 Symphyotrichum pilosum Species 0.000 description 1
- 235000004224 Typha angustifolia Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011295 pitch Substances 0.000 description 1
- 230000036544 posture Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
Abstract
The invention discloses a vertebral pedicle screw for promoting bone regeneration based on degradable hydrogel rich in exosome, and particularly relates to the technical field of vertebral pedicle screws. According to the invention, the reinforcing mechanism is arranged, the nail body is placed at the corresponding position of the spine of the patient, then the quickly-formed hydrogel loaded with the exosomes is injected into the hollow channel, the hydrogel releases the exosomes through the side hole channel, so that bone formation and bone marrow mesenchymal stem cell proliferation are promoted, the nail body is reinforced, operation failure caused by screw loosening is prevented, the hydrogel can slowly release the exosomes for a long time, the bone formation time is met, compared with the existing method, various complications can be effectively avoided, and the reinforcing effect is better.
Description
Technical Field
The invention relates to the technical field of pedicle screws, in particular to a pedicle screw for promoting bone regeneration based on degradable hydrogel rich in exosome.
Background
The internal fixation technology of the screw has been for centuries, and the internal fixation technology of the screw can be changed from a common screw to screws with different screw pitches and screw rods, then to hollow screws, hip screws, expansion screws, double-head thread screws, locking screws and the like, and even to certain screws used for specific parts, such as pedicle screws and the like, which are in various postures.
The pedicle screw is a medical instrument which is widely used in spinal surgeries, and is often necessary for patients of spinal internal fixation surgeries, and in addition, the pedicle screw and the rod can jointly form a spinal screw-rod internal fixation system, so that the treatment effect is improved.
However, for patients after internal fixation, especially in the case of osteoporosis, the contact surface between the bone and the internal fixation is weakened, the screw is loosened and pulled out after operation, and even fracture around the screw is generated, which finally leads to internal fixation failure.
Disclosure of Invention
In order to overcome the above-mentioned drawbacks of the prior art, the present invention provides a pedicle screw for promoting bone regeneration based on degradable hydrogel rich in exosome, to solve the problems occurring in the above-mentioned background art.
In order to achieve the purpose, the invention provides the following technical scheme: the vertebral pedicle screw capable of promoting bone regeneration based on the degradable hydrogel rich in exosomes comprises a screw body, wherein a reinforcing mechanism is arranged in the screw body;
the reinforcing mechanism comprises a ball head, the ball head is fixedly arranged on the top end of the nail body, a hollow channel is formed in the nail body, one end of the hollow channel runs through the ball head and extends to the top end of the ball head, a plurality of side hole channels are formed in two sides of the nail body, and one end of each side hole channel is communicated with the corresponding hollow channel.
Further, the fixed rubber head that is equipped with in nail body bottom, pole in the inside being equipped with of cavity passageway, pole outer end contacts with nail body inner wall in interior pole, the pole top extends to bulb top in the interior pole.
Further, the outer end of the inner rod is provided with a notch, the notch separates the inner rod into a sealing rod and a fixing rod, the fixing rod is arranged at the bottom of the sealing rod, the side hole channel is internally filled with a filling strip, and one end of the filling strip is fixedly connected with the outer end of the fixing rod.
Furthermore, a hemispherical shell is arranged at the top of the nail body, the top end of the nail body extends into the hemispherical shell, and the ball head is arranged in the hemispherical shell.
Furthermore, a sealing gasket is fixedly arranged on the inner wall of the hemispherical shell, the outer end of the ball head is in contact with the sealing gasket, a limiting hole is formed in the outer end of the ball head, the limiting hole is formed in the hemispherical shell, a limiting nail is arranged at the outer end of the hemispherical shell, one end of the limiting nail penetrates through the hemispherical shell and extends into the limiting hole, and the limiting nail is in threaded connection with the hemispherical shell.
Further, hemisphere shell top end is fixed and is equipped with two forked tails, two forked tail one side all is fixed and is equipped with the intubate, the intubate top is equipped with fastening bolt, fastening bolt one end extends to the intubate inside and passes through threaded connection with the intubate.
Further, the inside glide slope of having seted up of forked tail, the last slide has been seted up on the forked tail top, go up the slide bottom and be linked together with the glide slope, both sides around the forked tail are run through to glide slope and last slide both ends.
Further, two the forked tail top all is equipped with the extension piece, the inside circular slide bar that is equipped with of glide slope, the fixed rubber pad that is equipped with in circular slide bar outer end, the rubber pad outer end contacts with the glide slope inner wall, the fixed connection piece that is equipped with in circular slide bar top, the connection piece is established inside the glide slope, connection piece one end extends to the forked tail top, two the connection piece is fixed respectively and is established in two extension piece bottoms, the extension piece top is equipped with the extension bolt, extension bolt one end extends to between two extension pieces and passes through threaded connection with the extension piece.
The invention has the technical effects and advantages that:
1. according to the invention, the reinforcing mechanism is arranged, the nail body with the hollow channel is placed at the corresponding position of the spine of a patient by utilizing an internal spinal fixation operation, the spine is fixed, then the quickly-formed hydrogel loaded with exosomes is injected into the hollow channel, the hydrogel releases exosomes through the side hole channel, bone formation and bone marrow mesenchymal stem cell proliferation are promoted, osteoporosis is treated, the nail body is reinforced and the nail channel is strengthened, operation failure caused by screw loosening is prevented, the hydrogel is used as a good carrier, the exosomes can be slowly and long-term released, the bone formation time is conformed, compared with methods such as bone cement screws and biological hollow cancellous screws, various complications can be effectively avoided, and the reinforcing effect is better.
2. According to the invention, the semi-spherical shell and the dovetail are arranged at the top of the nail body, the insertion pipes at two sides of the dovetail are used for fixing the connecting rod, and the ball head can roll in the semi-spherical shell, so that the movable connection between the semi-spherical shell and the nail body is realized, the pull-out force of the connecting rod on the nail body is reduced, in addition, the dovetail and the extension sheet can be connected through the circular sliding rod, the connecting sheet, the upper slideway and the lower slideway, so that the nail tail is extended, and after the extension is finished, the extension sheet and the extension bolt can be detached from the dovetail.
Drawings
Fig. 1 is a perspective view of the present invention.
Fig. 2 is a perspective semi-sectional view of the present invention.
FIG. 3 is a perspective half sectional view of the dovetail and hemispherical shells of the present invention.
Fig. 4 is a three-dimensional semi-sectional view of the nail body of the invention.
Fig. 5 is a three-dimensional half-sectional view of the nail body of the invention.
FIG. 6 is a perspective view of the dovetail and hemispherical shells of the present invention.
Fig. 7 is a perspective view of an extension piece of the present invention.
The reference signs are: 1. a nail body; 2. a rubber head; 3. a hemispherical shell; 4. a ball head; 5. an extension sheet; 6. extending the bolt; 7. a dovetail; 8. inserting a tube; 9. a hollow channel; 10. a side hole channel; 11. a circular slide bar; 12. a rubber pad; 13. connecting sheets; 14. a gasket; 15. an upper slideway; 16. a lower slideway; 17. fixing the rod; 18. filling the strip; 19. a sealing rod; 20. a limit pin; 21. a limiting hole; 22. an inner rod; 23. and (4) a notch.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to the attached drawings 1-7 of the specification, the pedicle screw based on the degradable hydrogel rich in exosome for promoting bone regeneration of the embodiment comprises a screw body 1, wherein a reinforcing mechanism is arranged inside the screw body 1;
the strengthening mechanism includes bulb 4, bulb 4 is fixed to be established on 1 top of the nail body, 1 inside cavity passageway 9 has been seted up to the nail body, bulb 4 and 4 tops of extension are run through to cavity passageway 9 one end, a plurality of side opening passageways 10 have all been seted up to nail body 1 both sides, side opening passageway 10 one end is linked together with cavity passageway 9, injects the rapid prototyping aquogel of load exosome into cavity passageway 9, and aquogel passes through side opening passageway 10 release exosome, promotes bone formation and the mesenchymal stem cell proliferation of marrow, treats osteoporosis, and then consolidates, strengthens the nail way to nail body 1, prevents that the screw is not hard up and lead to the operation failure.
1 bottom mounting of the nail body is equipped with rubber head 2, pole 22 in the inside being equipped with of cavity passageway 9, pole 22 outer end contacts with 1 inner wall of the nail body, pole 22 top extends to 4 tops of bulb in, and the texture of rubber head 2 is softer, reduces the injury of 1 one end of the nail body to the backbone.
The implementation scenario is specifically as follows: when the internal fixation of the vertebral column is carried out, firstly, the corresponding position of the vertebral column of a patient is drilled, then the nail body 1 is completely arranged in the hole, so that the nail body 1 and the hollow channel 9 inside the nail body can be completely deep into the vertebral column, in the process, the inner rod 22 is completely positioned inside the hollow channel 9, the inner rod 22 is divided into the sealing rod 19 and the fixing rod 17, the outer end of the fixing rod 17 is fixedly provided with a plurality of filling strips 18, the fixing rod 17, the filling strips 18 and the sealing rod 19 are all made of medical rubber materials, the texture is soft and elastic, in the process of arranging the nail body 1 in the hole, the filling strips 18 are filled inside the side hole channel 10, so that chips generated in the drilling process can be prevented from entering the side hole channel 10 or the hollow channel 9, the hollow channel 9 or the side hole channel 10 is blocked, after the nail body 1 is arranged, the whole inner rod 22 is slowly drawn out of the hollow channel 9, in the process of extraction, the filling strip 18 is also extracted from the side hole channel 10, so that the side hole channel 10 is communicated with the hollow channel 9, then the rapid forming hydrogel loaded with exosomes can be injected into the hollow channel 9, the hydrogel flows to the deep part of the spine through the hollow channel 9 and then flows to the spine through the side hole channel 10, so that the exosomes are slowly released, the exosomes are slowly and permanently acted on the fixed local position of the nail body 1, the purposes of treating osteoporosis and strengthening the nail channel are achieved, the operation failure caused by loosening, extraction and even fracture around the screw is prevented, after the injection of the hydrogel is finished, the inner rod 22 can be cut off at the notch 23, only the sealing rod 19 is reserved, then the sealing rod 19 is inserted into the hollow channel 9 again to seal the hollow channel 9, the nail body 1 with the hollow channel 9 is placed at the corresponding position of the spine of a patient by utilizing the internal fixation operation of the spine through the arrangement of the strengthening mechanism, the spine is fixed, then the quick forming hydrogel loaded with exosomes is injected into the hollow channel 9, the hydrogel releases exosomes through the side hole channel 10, bone formation and bone marrow mesenchymal stem cell proliferation are promoted, osteoporosis is treated, the nail body 1 is reinforced and the nail channel is strengthened, operation failure caused by screw loosening is prevented, the hydrogel is used as a good carrier, exosomes can be slowly and long-term released, the time of bone formation is met, compared with methods such as bone cement screws and biological hollow spongy bone screws, various complications can be effectively avoided, and the reinforcing effect is better.
Referring to the attached drawings 1-7 in the specification, the pedicle screw based on the degradable hydrogel rich in exosome for promoting bone regeneration of the embodiment is characterized in that a hemispherical shell 3 is arranged at the top of a screw body 1, the top end of the screw body 1 extends into the hemispherical shell 3, and a ball head 4 is arranged inside the hemispherical shell 3.
The inner wall of the hemispherical shell 3 is fixedly provided with a sealing gasket 14, the outer end of the ball head 4 is in contact with the sealing gasket 14, the outer end of the ball head 4 is provided with a limiting hole 21, the limiting hole 21 is formed in the hemispherical shell 3, the outer end of the hemispherical shell 3 is provided with a limiting nail 20, one end of the limiting nail 20 penetrates through the hemispherical shell 3 and extends into the limiting hole 21, the limiting nail 20 is in threaded connection with the hemispherical shell 3, the movement of the ball head 4 is limited when the nail body 1 is installed, and inconvenience in operation is avoided.
The top end of the hemispherical shell 3 is fixedly provided with two dovetails 7, two inserting pipes 8 are fixedly arranged on one sides of the dovetails 7, fastening bolts are arranged on the top ends of the inserting pipes 8, one ends of the fastening bolts extend to the insides of the inserting pipes 8 and are connected with the inserting pipes 8 through threads, and the fastening bolts are fixedly connected with rods through the two inserting pipes 8.
The inside glide slope 16 of having seted up of forked tail 7, last slide 15 has been seted up on 7 tops of forked tail, 15 bottoms of last slide are linked together with glide slope 16, both sides around forked tail 7 are run through at glide slope 16 and the 15 both ends of last slide to extension piece 5 and forked tail 7 are connected to this.
Two the 7 top of forked tail all is equipped with extension piece 5, 16 inside circular slide bar 11 that is equipped with of glide slope, the fixed rubber pad 12 that is equipped with in circular slide bar 11 outer end, rubber pad 12 outer end contacts with 16 inner walls of glide slope, the fixed connection piece 13 that is equipped with in circular slide bar 11 top, connection piece 13 is established inside last slide 15, connection piece 13 one end extends to forked tail 7 top, two connection piece 13 is fixed respectively and is established in two 5 bottoms of extension pieces, extension piece 5 top is equipped with extension bolt 6, 6 one end of extension bolt extend to between two extension pieces 5 and pass through threaded connection with extension piece 5 to this further extension is carried out the nail tail.
The implementation scenario is specifically as follows: in the actual use process, the nail body 1 is often matched with a connecting rod to form a spinal nail rod internal fixing system so as to improve the treatment effect, therefore, the top of the nail body 1 is provided with the hemispherical shell 3, the top end of the hemispherical shell 3 is fixedly provided with the two dovetails 7, one side of each of the two dovetails 7 is fixedly provided with the insertion tube 8, after the nail body 1 is fixed, the connecting rod can successively pass through the two insertion tubes 8, then the fastening bolt at the top end of the insertion tube 8 is screwed, the connecting rod is fixed, so that the nail body 1 is connected with the connecting rod, the hemispherical shell 3 is arranged at the outer end of the ball head 4, therefore, the ball head 4 can roll in the hemispherical shell 3, so that the nail body 1 is movably connected with the hemispherical shell 3, so as to reduce the pull-out force of the connecting rod on the nail body 1, but the operation is inconvenient if the hemispherical shell 3 and the nail body 1 are movably connected in the process of installing the nail body 1, so that the limit nail 20 passes through the hemispherical shell 3 and extends to the limit hole 21, when the nail body 1 is installed, the movement of the ball head 4 is limited, when the nail body 1 and the connecting rod are fixed, the limit nail 20 can be taken down, so that the hemispherical shell 3 and the ball head 4 can move mutually, in addition, in the operation process, the connecting sheet 13 and the circular slide bar 11 at the bottom ends of the two extension sheets 5 can respectively correspond to the upper slide way 15 and the lower slide way 16 at the top ends of the two dovetails 7, the connecting sheet 13 and the circular slide bar 11 are clamped into the upper slide way 15 and the lower slide way 16 in a sliding way, so that the extension sheets 5 and the dovetails 7 are connected, the length of the nail tail is increased, the operation is convenient, if the length is still insufficient, one end of the extension bolt 6 can be fixed between the two extension sheets 5 through threads, the length of the nail tail is further increased, after the operation is finished, the extension sheets 5 and the extension bolt 6 can be detached from the dovetails 7, compared with the traditional long-arm nail, the nail tail does not need to be cut, more convenient, through set up hemisphere shell 3 and forked tail 7 at nail body 1 top, the intubate 8 that utilizes forked tail 7 both sides is fixed the connective bar, bulb 4 can roll in hemisphere shell 3 inside simultaneously, realize hemisphere shell 3 and nail body 1's swing joint, the pull-out force of connective bar to nail body 1 has been reduced, furthermore, can also be through circular slide bar 11, connection piece 13 and last slide 15, forked tail 7 and extension piece 5 are connected to lower slide 16, prolong the nail tail, the extension finishes the back, extension piece 5 and extension bolt 6 all can be followed forked tail 7 and dismantled, compare with traditional long-armed nail, need not to cut the nail tail, it is more convenient.
The points to be finally explained are: first, in the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounted," "connected," and "connected" should be understood broadly, and may be a mechanical connection or an electrical connection, or a communication between two elements, and may be a direct connection, and "upper," "lower," "left," and "right" are only used to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed;
secondly, the method comprises the following steps: in the drawings of the disclosed embodiments of the invention, only the structures related to the disclosed embodiments are referred to, other structures can refer to common designs, and the same embodiment and different embodiments of the invention can be combined with each other without conflict;
and finally: the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention are intended to be included in the scope of the present invention.
Claims (8)
1. Pedicle screw based on degradable aquogel that is rich in exosome promotes bone regeneration, including the nail body (1), its characterized in that: a reinforcing mechanism is arranged inside the nail body (1);
reinforcing mechanism includes bulb (4), bulb (4) are fixed to be established on nail body (1) top, the inside cavity passageway (9) of having seted up of nail body (1), bulb (4) are run through to cavity passageway (9) one end and extend to bulb (4) top, a plurality of side opening passageways (10) have all been seted up to nail body (1) both sides, side opening passageway (10) one end is linked together with cavity passageway (9).
2. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 1, characterized in that: the nail body (1) bottom mounting is equipped with rubber head (2), pole (22) in cavity passageway (9) inside being equipped with, pole (22) outer end contacts with nail body (1) inner wall, pole (22) top extends to bulb (4) top.
3. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 2, characterized in that: breach (23) have been seted up to interior pole (22) outer end, breach (23) are separated interior pole (22) for sealing rod (19) and dead lever (17), dead lever (17) are established in sealing rod (19) bottom, the inside packing of side opening passageway (10) has packing strip (18), packing strip (18) one end and dead lever (17) outer end fixed connection.
4. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 1, characterized in that: the nail is characterized in that a hemispherical shell (3) is arranged at the top of the nail body (1), the top end of the nail body (1) extends into the hemispherical shell (3), and the ball head (4) is arranged inside the hemispherical shell (3).
5. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 4, characterized in that: hemisphere shell (3) inner wall is last to be fixed to be equipped with sealed pad (14), bulb (4) outer end contacts with sealed pad (14), spacing hole (21) have been seted up to bulb (4) outer end, spacing hole (21) are established inside hemisphere shell (3), hemisphere shell (3) outer end is equipped with spacing nail (20), spacing nail (20) one end runs through hemisphere shell (3) and extends to inside spacing hole (21), spacing nail (20) pass through threaded connection with hemisphere shell (3).
6. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 4, characterized in that: hemisphere shell (3) top is fixed to be equipped with two forked tail (7), two forked tail (7) one side all is fixed and is equipped with intubate (8), intubate (8) top is equipped with fastening bolt, fastening bolt one end extends to intubate (8) inside and passes through threaded connection with intubate (8).
7. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 6, characterized in that: the inside glide slope (16) of having seted up of forked tail (7), last slide (15) have been seted up on forked tail (7) top, it is linked together with glide slope (16) to go up slide (15) bottom, both sides around forked tail (7) are run through at glide slope (16) and last slide (15) both ends.
8. Pedicle screw for promoting bone regeneration based on degradable exosome-rich hydrogels according to claim 7, characterized in that: two forked tail (7) top all is equipped with extension piece (5), the inside circular slide bar (11) that is equipped with of glide slope (16), circular slide bar (11) outer end is fixed and is equipped with rubber pad (12), rubber pad (12) outer end contacts with glide slope (16) inner wall, circular slide bar (11) top is fixed and is equipped with connection piece (13), connection piece (13) are established inside last slide (15), connection piece (13) one end extends to forked tail (7) top, two connection piece (13) are fixed respectively and are established in two extension piece (5) bottoms, extension piece (5) top is equipped with extension bolt (6), extension bolt (6) one end extends to between two extension pieces (5) and passes through threaded connection with extension piece (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111081941.9A CN113768597A (en) | 2021-09-15 | 2021-09-15 | Vertebral pedicle screw capable of promoting bone regeneration based on degradable hydrogel rich in exosome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111081941.9A CN113768597A (en) | 2021-09-15 | 2021-09-15 | Vertebral pedicle screw capable of promoting bone regeneration based on degradable hydrogel rich in exosome |
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| CN113768597A true CN113768597A (en) | 2021-12-10 |
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| CN202111081941.9A Withdrawn CN113768597A (en) | 2021-09-15 | 2021-09-15 | Vertebral pedicle screw capable of promoting bone regeneration based on degradable hydrogel rich in exosome |
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| CN209770522U (en) * | 2019-01-28 | 2019-12-13 | 宁德市闽东医院 | Improved U-shaped hollow pedicle screw with solid bolt |
| CN210114489U (en) * | 2019-05-24 | 2020-02-28 | 焦作市新港医疗设备有限公司 | Breakable U-shaped nail |
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| CN211408538U (en) * | 2019-12-28 | 2020-09-04 | 义乌市镔瑞工艺品有限公司 | Christmas decorations |
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Application publication date: 20211210 |
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