CN113749719A - Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof - Google Patents
Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof Download PDFInfo
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- CN113749719A CN113749719A CN202110600226.5A CN202110600226A CN113749719A CN 113749719 A CN113749719 A CN 113749719A CN 202110600226 A CN202110600226 A CN 202110600226A CN 113749719 A CN113749719 A CN 113749719A
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
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- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
Abstract
The invention relates to the field of medical instruments, in particular to an implantation instrument with fishbone-shaped anchoring structures and a conveying system thereof, wherein the implantation instrument at least comprises a fixing part, the fixing part comprises a supporting body, the supporting body comprises a plurality of elastic supporting rods and a plurality of anchoring structures, each supporting rod comprises an inner side, an outer side and a side wall, and the plurality of anchoring structures are distributed on the side walls and/or the outer sides of the supporting rods in a fishbone shape; when the implantation instrument is placed in the cavity, the distal end of the anchoring structure and the outer side of the support rod can contact the inner surface of the cavity and form a non-penetrating anchor.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to an implantation instrument with a fishbone-shaped anchoring structure and a conveying system thereof.
Background
Currently, in the field of cardiovascular and cerebrovascular medicine, atrial fibrillation is the most common sustained arrhythmia in clinic, atrial fibrillation can cause rapid and chaotic arrhythmia, further causes symptoms such as palpitation, chest distress, dizziness and the like, causes reduction of cardiac blood output, and has irregular and disordered blood flow in a vascular system, which can cause death or disability in severe cases, and seriously affects the health and life quality of people. Prevention of stroke is therefore a fundamental goal in atrial fibrillation therapy. There are over tens of millions of people worldwide with atrial fibrillation occurring, with about 40 million new cases each year. In which atrial fibrillation is at risk of stroke by more than 50%. Patients with atrial fibrillation also have a greatly reduced quality of life, due in part to concerns about stroke occurrence and the need for long-term administration of anticoagulant drugs to prevent thrombosis. The left atrial appendage communicates with the left atrium, and contracts or expands with the left atrium during normal cardiac blood circulation. However, the cavity structure of the left auricle is complex, the comb-shaped muscles inside the auricle are abundant, and the grooves at certain positions are deeper, so that blood stagnates in the auricle, and thrombus is easily formed. In addition, in the case of atrial fibrillation, uncoordinated electrical signals often cause a disturbance in the blood circulation in the left atrium, partial stagnation of blood, and failure of the atrium to properly contract or dilate, with the result that blood trapped in the left atrial appendage is easily thrombosed at this point. Currently, the clinical prevention of atrial fibrillation for the left atrial appendage is mainly focused on the closure of the left atrial appendage, wherein a left atrial appendage closure device is a widely accepted treatment method at the present stage.
Patent CN207666637U provides a left atrial appendage occluder with strong adaptability, which comprises an occluding disk, an anchoring part and a connecting part connecting the occluding disk and the anchoring part; the left auricle is blocked by a blocking disc, wherein the arrangement of the supporting disc frame and the flow-blocking film has small contraction volume and lighter weight compared with other metal-woven blocking discs, and the flow-blocking film is used for blocking blood from entering and exiting the left auricle; especially, the unique design of cover bag specifically is that cover bag cover establishes on the support ring of support plate rail periphery, and intraoperative cover bag packs elastic material, and when cover bag and left atrial appendage mouth match, because the cover bag elasticity and the pliability of packing elastic material are better, adaptable left atrial appendage mouth irregularly shaped, the left atrial appendage mouth of complete shutoff has solved traditional plugging device and can not solve the not tight problem of different individual left atrial appendage mouth shutoff, has thoroughly eliminated the hidden danger that causes the left atrial appendage portion to form the thrombus because of the atrial fibrillation.
Patent CN210354812U provides an anchor formula left atrial appendage plugging device, including plugging piece and mounting, the plugging piece is including the flat cage form cock body that the knitting silk formed, the cock body top draws in the bellying that forms the taper through knitting silk transition, the fixed cover in top of bellying is equipped with the overhead guard, the mounting is including the fixed adapter sleeve of locating on the overhead guard of cover, the adapter sleeve top is equipped with the support arm of many the types of falling U, the mounting is still including the linking piece of connecting adjacent two support arm tip, the linking piece includes the curved hook portion of tilt-up and sets up in two curved branch portions of curved hook portion bottom, curved hook portion's top extends towards the adapter sleeve, be equipped with the anchor thorn of buckling towards the plugging piece on the support arm. The fixing piece can be stably connected and matched with the left auricle through the hooking and anchoring dual functions, the whole fixing condition of the plugging device is favorably improved, the stable and durable plugging effect is achieved on the left auricle, and the anchoring thorn of the design structure can easily scratch the inner wall of the left auricle.
Patent CN108938037A provides a left auricle occluder, including support and the anchor of setting on the support, the anchor includes main part, fixed part and hook-shaped portion, the main part links to each other with hook-shaped portion and support respectively, the fixed part sets up on hook-shaped portion and extends to keeping away from the main part direction, when the occluder is arranged in and is waited to occlude the object, the anchor passes through the fixed part with wait to occlude the object and be connected, the invention both can adapt to the left auricle of various different shapes, can not hinder the occluder to go into the sheath simultaneously, it is convenient to go into the sheath, and also difficult fish tail sheath pipe, be favorable to repeated positioning and recovery, and fixed convenient, the operating efficiency is high, but the anchor is very easy to scrape the vascular wall.
Therefore, how to improve the anchoring effect of the left auricle occluder in the operation process and prevent the left auricle occluder from puncturing the wall of the left auricle without hindering the occluder from entering the sheath, preventing the left auricle occluder from scratching the sheath tube, repeatedly positioning and recovering the left auricle occluder, and improving the operation efficiency becomes a problem to be solved urgently at present.
Disclosure of Invention
In view of the above and other, it is an object of the present invention to overcome the deficiencies of the prior art.
According to an embodiment in the application aspect of the left atrial appendage occlusion of the heart, the invention can provide an implantation instrument with a fishbone-shaped anchoring structure and a conveying system thereof for patients with structural heart disease and needing interventional therapy, and can solve the problems that the wall of the left atrial appendage is scratched and the wall of a sheath is scratched by an occluder in the interventional therapy process.
According to one aspect of the invention, the implantation instrument at least comprises a fixing part, the fixing part comprises a support body, the support body comprises a plurality of elastic supporting rods and a plurality of anchoring structures, the supporting rods comprise inner sides, outer sides and side walls, and the plurality of anchoring structures are distributed on the side walls and/or the outer sides of the supporting rods in a fishbone shape; when the implantation instrument is placed in the cavity, the distal end of the anchoring structure and the outer side of the support rod can contact the inner surface of the cavity and form a non-penetrating anchor.
In one embodiment, the implantation device with the fishbone-shaped anchoring structure comprises a ductal arteriosus occluder, a left atrial appendage occluder, an arterial/venous filter, a thrombectomy device.
In one embodiment, the side of the support rod close to the central axis is the inner side, the side of the support rod far from the central axis is the outer side, and the other parts except the inner side and the outer side are the side walls of the support rod from the inner side to the outer side of the central axis of the fixing part.
In one embodiment, the anchoring structure is not elastically deformable relative to the support rod.
In one embodiment, the anchoring structure is not elastically deformable relative to the support rod at any state during the entire procedure after the implantation instrument reaches the target position in the cavity during the pushing of the implantation instrument into the target position by the delivery system in the unloaded state of the implantation instrument outside the body.
In one embodiment, the support rod is preferentially elastically deformable during release of the implantation instrument, and the anchoring structure is not elastically deformable relative to the support rod.
In one embodiment, non-penetrating anchoring means that the distal end of the anchoring structure penetrates the luminal tissue in a limited area and at a very shallow depth, increasing the frictional resistance to some extent.
In one embodiment, the fixing part further comprises a self-centering member, the support rods are radially distributed outwards from the self-centering member and sequentially comprise a proximal connecting rod, a middle branch rod and a distal ring-shaped rod, and the distal ring-shaped rod is curved or at least one section of the distal ring-shaped rod is parallel to the central axis of the self-centering member in the general direction; wherein, the anchoring structure is in a fishbone shape and is at least distributed on the side wall of the far-end ring-shaped rod, and the distance from the tail end of the anchoring structure to the edge of the side wall of the supporting rod is not more than 1 mm; when the implantation instrument is in any state, any anchoring structure is on a plane, and the plane and the distal ring-shaped rod are tangent to a tangent point, wherein the tangent point is a connection point where the anchoring structure and the distal ring-shaped rod are intersected.
In one embodiment, the support body is formed by laser engraving and heat setting the same shape memory alloy tube.
In one embodiment, the anchoring structures are distributed on both side walls of the distal loop-like rod, and when the implantation instrument is in a natural unconstrained state, either anchoring structure is on a plane that is tangent to the side walls of the distal loop-like rod at a point of tangency, which is a point of connection where the anchoring structures meet the distal loop-like rod, with the anchoring structures facing radially outward.
In another embodiment, the anchoring structures are distributed on both side walls of the distal loop-like rod, and when the implantation instrument is in a natural unconstrained state, either anchoring structure is on a plane that is tangent to the outside of the distal loop-like rod at a point of tangency that is a point where the anchoring structure meets the distal loop-like rod.
In one embodiment, the overall shape of the anchoring structure is one or more of a horn, a bicuspid, a trident, a tetradentate, a pentadentate, and a wing; wherein, the length of the curve of each anchoring structure is 0.2mm and 2mm, and the distance between the adjacent anchoring structures along the direction of the supporting rod is 0.5mm and 2 mm.
In one embodiment, the tube material of the shape memory alloy tube has a wall thickness of [0.05mm, 0.5mm ] and an outer diameter of [1mm, 5mm ].
In a preferred embodiment, the wall thickness of the tube material of the shape memory alloy tube is [0.15mm, 0.3mm ], and the outer diameter is [2mm, 4mm ].
In one embodiment, each anchoring structure presents a gradually widening shape from distal to proximal of the support rod.
In one embodiment, the implantation instrument and its delivery system include a spacer structure, wherein, when the implantation instrument is loaded within the delivery system, the spacer structure is at least partially positioned between the distal ends of all of the anchoring structures and the inner wall of the delivery system; the isolation structure is at least partially located within the medial side of the support rod or within the medial side of the distal end of the anchoring structure when the implantation instrument is positioned in the target position within the cavity.
In one embodiment, the distance from the end of the anchoring structure to the edge of the distal loop-rod sidewall is [0.2mm, 0.5mm ].
In one embodiment, the spacer structures are disposed on the implantation instrument and spaced apart at the ends of the anchoring structures, or between two adjacent anchoring structures, or within the inner side of the distal loop-like rod, or a combination thereof; wherein the isolation structures comprise one or more of bulbs, bumps, cutting heads, pellets, and packed thickened coatings, as shown in fig. 3 e.
In one embodiment, the outer sides of the central piece, the proximal connecting rods and the middle branch rods are connected with flexible outer covering films, the inner sides of the distal ring-shaped rods are connected with flexible inner covering films, and the inner covering films are isolation structures; wherein, the outer coating and the inner coating can form an integrated structure or a split type connecting structure.
In one embodiment, the split-type connection structure comprises a local connection structure, the local connection structure is sewn or glued, and the microstructure and the forming structure of each part of the split-type connection structure are different from the manufacturing method.
In one embodiment, the microstructure and the formed structure of the various portions of the unitary structure and the process of fabrication are consistent.
In one embodiment, the anchoring structure is located on a proximal connector rod, or a mid-section rod, or a distal loop rod, or a combination of the three.
In one embodiment, the anchoring structure may be distally and/or proximally directed.
In one embodiment, the outer coating and the inner coating are formed as an integral structure by reverse insertion through the support.
In one embodiment, the coating film is one or more of a silicone film, a polyurethane film, a polyester film, a polytetrafluoroethylene film, a polyethylene film, a polypropylene film, a polylactic acid film, a polycaprolactone film, and a polyvinyl alcohol film.
In a preferred embodiment, the cover is fixed to the support by stitching.
In one embodiment, the fixing part is internally provided with a layer of film, which plays a role in blocking, prevents the anchoring structures from rubbing against each other to generate self-locking and scratch the wall of the sheath, and the fixing part is also externally provided with a layer of film for blocking thrombus.
In one embodiment, the proximal end of the fixing portion is provided with a blocking portion, and the blocking portion is of a three-dimensional structure and used for blocking the cavity opening area.
In one embodiment, the isolation structure is disposed on a delivery system, the delivery system including an outer sheath and a control handle, the isolation structure being positionable between the outer sheath and the fixation section.
In one embodiment, the isolation structure includes a flexible cover capable of covering at least the distal ends of all of the anchoring structures and a detachable connection structure operable to allow the cover to be detached so that the anchoring portion is fully exposed from the cover and radially expanded to a predetermined shape.
In one embodiment, the delivery system further comprises a control wire, the isolation structure is a wrapping film, a plurality of through holes are formed in the wrapping film, the plurality of through holes are distributed spirally, one end of the control wire is used for being detachably arranged after sequentially penetrating through the plurality of through holes, the other end of the control wire is connected with the control handle, after the fixing portion reaches the expected release position, the control handle is operated, one end of the control wire is sequentially pulled out of the plurality of through holes to gradually release radial restraint on the wrapping film, and the fixing portion is gradually radially expanded to the preset shape.
In one embodiment, the isolation structure is an isolation tube having an inner surface hardness not less than the hardness of the end of the anchoring structure or having an inner surface roughness not greater than the surface roughness of the end of the anchoring structure; before the fixed part is not restored to the preset shape, the fixed part and the isolation pipe are kept relatively static in the axial direction; after the anchoring portion has returned to the predetermined shape, the sheath and spacer tube are retracted simultaneously to complete the surgical procedure.
In one embodiment, as shown in FIG. 7a, the isolation structure is a second fixation portion of a portion of the implantation instrument, the second fixation portion being located inside the fixation portion and having a support structure.
In one embodiment, as shown in fig. 7b and 7c, the anchoring portion comprises a reinforcement member comprising a plurality of resilient reinforcement rods, at least a portion of the reinforcement rods being in contact with the inner surface of the lumen; the reinforcing rod is formed by dispersing the reinforcing rod outside the far end of the support body from the central piece and/or the supporting rod and then dissociating the reinforcing rod, the reinforcing rod comprises an inner face, an outer face and side faces, and the support body and the reinforcing body form a three-dimensional structure.
In one embodiment, the distal end of the reinforcing rod is provided with a cushioning structure comprising one or more of a ring, a bulb, a bump, a rod width taper structure.
In one embodiment, the side of the reinforcing rod close to the central axis is an inner surface, the side of the reinforcing rod far from the central axis is an outer surface, and the other parts except the inner surface and the outer surface are side surfaces of the reinforcing rod from the inside to the outside of the central axis of the fixing part.
In one embodiment, the reinforcing rod is provided with or without an anchoring structure.
In a preferred embodiment, as shown in fig. 7b, the reinforcing rod is provided with a plurality of anchoring structures, the anchoring structures comprise fishbone and hook thorn, the hook thorn is J-shaped, and the free end of the hook thorn is far away from the central axis direction of the fixing part; several anchoring structures are distributed on the sides and/or outside of the reinforcing rods.
In one embodiment, the occluding portion is made of a material having elasticity and shape memory, and the occluding portion has a three-dimensional cage-like structure.
In one embodiment, a three-dimensional coating is provided on the occlusion portion.
Compared with the prior art, the invention has the advantages that:
1. taking left atrial appendage occlusion as an example, in the left atrial appendage occlusion at present, the problems that the anchoring effect of an anchoring structure is insufficient and the anchoring structure punctures the wall of the left atrial appendage easily occur, and meanwhile, the anchoring structure can prevent an occluder from entering a sheath and even scratch a sheath tube, so that the occluder cannot be repeatedly positioned and recovered, the operation effect is influenced, and the left atrial appendage occlusion is different from the prior art; when the implantation instrument is arranged in the cavity, the tail end of the anchoring structure and the outer side of the supporting rod can be in contact with the inner surface of the cavity, non-penetrating anchoring is formed, and the safety and practicability are improved while the anchoring effect is improved.
2. Different from the prior art, in one embodiment of the invention, the anchoring structure is not elastically deformable relative to the supporting rod, the anchoring structure is in a fishbone shape and is at least distributed on the side wall of the far-end ring-shaped rod, and the distance from the tail end of the anchoring structure to the edge of the side wall of the supporting rod is not more than 1 mm; the support body is formed by laser engraving and heat setting of the same shape memory alloy pipe; when the implantation instrument is in any state, any anchoring structure is on the plane, and the plane and the far-end ring-shaped rod are tangent to a tangent point, the tangent point is a connection point where the anchoring structure and the far-end ring-shaped rod are intersected, the process is simple, thereby ensuring that the anchoring structure has a certain curve radian on the whole and the curve radian of the far-end ring-shaped body is limited, so that the distance from the end of the anchoring structure to the distal collar is very short, so that the anchoring structure is only slightly pointed on the distal collar, thereby can realize guaranteeing that the anchoring structure fully anchors to autologous tissue when the non-formula of stabbing is anchored, strengthen anchoring effect, improve frictional resistance and security, reduce the risk that left atrial appendage occluder drops because reasons such as atrial fibrillation, reduce the risk that the anchoring structure alternates the left atrial appendage wall to can carry out the repeated positioning and retrieve to left atrial appendage occluder.
3. Different from the prior art, in one embodiment of the invention, each anchoring structure presents a gradually-widened structure from far to near from the support rod, so that the local non-penetrating anchoring of the anchoring structure can be realized, the probability of the non-penetrating anchoring is increased, and when the support body is formed by laser engraving and heat setting of the same shape memory alloy tube, the fatigue fracture resistance in the supporting process is improved.
4. In contrast to the prior art, in one embodiment of the present invention, when the implantation instrument is loaded into the delivery system, the spacer structure is at least partially positioned between the distal ends of all of the anchoring structures and the inner wall of the delivery system; the isolation structure is at least partially located within the medial side of the support rod or within the medial side of the distal end of the anchoring structure after the implantation instrument is positioned in the target position within the cavity; the distance from the tail end of the anchoring structure to the side wall edge of the far-end ring-shaped rod is [0.2mm, 0.5mm ], and the isolation structure plays an isolation role, so that the wall of the sheath tube is prevented from being scratched in the in-and-out process of the implantation instrument, and the probability of non-penetrating anchoring is improved.
5. In contrast to the prior art, in an embodiment of the present invention, the isolation structures are disposed on the implantation instrument and spaced apart from the ends of the anchoring structures, or between two adjacent anchoring structures, or inside the inner side of the distal loop-shaped rod, or a combination of the three; wherein, isolation structure includes bulb, bump, cutting head, bobble, fills one or more in the bodiness coating, has improved safe practicality when increasing anchoring effect to prevent that the apparatus of implanting from cominging in and going out sheath pipe in-process and scraping the sheath pipe wall.
6. Different from the prior art, the outer covering film and the inner covering film can be integrated films or split films, the inner covering film forms an isolation structure, the outer covering film has a barrier effect on the anchoring structure, and when the implantation instrument enters or exits the sheath tube, the implantation instrument is prevented from being clamped in the sheath tube due to interlocking of the anchoring structures, and meanwhile the anchoring structure can be prevented from scratching the wall of the sheath tube.
7. Different from the prior art, in one embodiment of the invention, the isolation structure is arranged on the delivery system and can be located between the outer sheath and the fixing part, when the isolation structure comprises a flexible film and a detachable connecting structure, the film can at least cover the tail ends of all the anchoring structures, the detachable connecting structure is operated, the film is detached, so that the fixing part is completely exposed from the film and radially expands to a preset shape, the operation is simple, and the implantation instrument is prevented from scratching the wall of the sheath.
8. In an embodiment of the present invention, when the isolation structure is an isolation pipe, the hardness of the inner surface of the isolation pipe is not lower than the hardness of the end of the anchoring structure, or the roughness of the inner surface of the isolation pipe is not higher than the roughness of the end of the anchoring structure, and before the fixing portion is not restored to the preset shape, the fixing portion and the isolation pipe are kept relatively stationary in the axial direction; after the fixing part is restored to the preset shape, the sheath and the isolation tube are withdrawn simultaneously to complete the operation process, so that the implantation instrument can be ensured to smoothly come in and go out of the sheath tube, and the isolation effect is achieved.
9. Different from the prior art, in an embodiment of the invention, the isolation structure is a second fixing portion which is a part of the implantation instrument, the second fixing portion is located on the inner side of the fixing portion and has the support body structure, the support effect is enhanced, and the isolation effect is achieved at the same time, so that the fixing portion is prevented from scratching the inner wall of the sheath.
10. Different from the prior art, in an embodiment of the invention, the reinforcing rod is formed by the self-centering piece and/or the supporting rod which is scattered outside the far end of the supporting body and then dissociated, the supporting body and the reinforcing body form a three-dimensional configuration, so that the overall height of the fixing part is increased, the stability, the centering property and the flexibility of the fixing part are enhanced, the probability of triggering and anchoring the fixing part is improved, and when the reinforcing rod is provided with an anchoring structure, the anchoring property of the fixing part is further improved.
11. Different from the prior art, the tail end of the reinforcing rod is provided with the buffer structure in one embodiment of the invention, and the buffer structure comprises one or more of a circular ring, a ball head, salient points and a rod width reducing structure, so that the wall of a sheath can be prevented from being scratched or the inner wall of a cavity can be prevented from being stabbed.
Drawings
Fig. 1a to 1e are schematic views showing the state of an implanting device with a fishbone-shaped anchoring structure according to an embodiment of the invention.
Fig. 2 a-2 e are schematic views of different overall shapes of anchoring structures according to an embodiment of the present invention.
Fig. 3a to 3d are schematic views of an isolation structure as an outer coating film according to an embodiment of the invention.
Fig. 3e is a schematic diagram illustrating a state in which the isolation structure is a ball head according to an embodiment of the present invention.
FIGS. 4 a-4 j are schematic diagrams illustrating the release of the implantation device in the left atrial appendage in accordance with one embodiment of the present invention.
FIG. 5 is a schematic view of the isolation structure of the second embodiment of the present invention being an isolation tube.
Fig. 6a to 6d are schematic views illustrating a process of releasing the implantation device in the left atrial appendage according to the third embodiment of the present invention.
Fig. 7a is a schematic view illustrating a state where the isolation structure is the second fixing portion according to an embodiment of the invention.
FIGS. 7b and 7c are schematic views of a state in which the fixing portion includes a reinforcement member according to an embodiment of the present invention.
The names of the parts indicated by the numbers in the drawings are as follows: 1-implantation instrument, 11-fixation section, 111-self-centering section, 112-proximal joint section, 113-medial branch bar, 114-distal loop bar, 115-second fixation section, 12-occlusion section, 13-support body, 14-support bar, 141-lateral side, 142-medial side, 143-lateral side, 2-anchoring structure, 3-outer covering film, 31-inner covering film, 4-delivery outer sheath, 5-control handle, 51-steel cable, 52-loader, 6-isolation tube, 7-covering film, 71-bulb, 8-control wire, 9-reinforcement body, 91-reinforcement bar.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples.
Proximal in the present invention means the end closer to the operator and distal means the end further away from the operator.
The first embodiment is as follows:
in this embodiment, as shown in fig. 1a to 1e, taking the intervention of left atrial appendage to prevent thromboembolic disease of atrial fibrillation patient as an example, an implantation apparatus with a fishbone anchoring structure and a delivery system thereof are provided, where the implantation apparatus 1 includes a fixing portion 11 and a blocking portion 12, the blocking portion 12 is a three-dimensional cage-shaped structure for blocking an opening area of a cavity, the blocking portion 12 is made of a material with elasticity and shape memory, the fixing portion includes a supporting body 13, the supporting body 13 includes a plurality of elastic supporting rods 14 and a plurality of anchoring structures 2, the supporting rods 14 include an inner side 142, an outer side 141 and a side wall 143, and the plurality of anchoring structures 2 are distributed on the side wall 143 of the supporting rods 14 in a fishbone shape; when the implantation instrument 1 is placed in the cavity, the distal end of the anchoring structure 2 and the outer side 141 of the support rod 14 can contact the inner surface of the cavity and form a non-penetrating anchor.
In this embodiment, the implantation device with the fishbone-shaped anchoring structure is a left atrial appendage occluder.
In this embodiment, the anchoring structure 2 is not elastically deformable relative to the supporting bar 14.
In this embodiment, from the inside to the outside of the central axis of the fixing portion 11, the side of the supporting rod 14 close to the central axis is the inside 142, the side of the supporting rod 14 away from the central axis is the outside 141, and the other parts except the inside and the outside are the side walls 143 of the supporting rod 14.
In this embodiment, in the process of pushing the implantation instrument 1 into the target position by the delivery system in the state that the implantation instrument 1 is not loaded outside the body, after the implantation instrument 1 reaches the target position of the cavity, the anchoring structure 2 cannot be elastically deformed relative to the supporting rod 14 in any state in the whole process.
In this embodiment, the supporting rod 14 is preferentially elastically deformed during the release of the implantation instrument 1, and the anchoring structure 2 is not elastically deformable relative to the supporting rod 14.
In this embodiment, non-penetrating anchoring means that the distal end of the anchoring structure 2 penetrates the cavity tissue in a limited area and at a very shallow depth, increasing the frictional resistance to a certain extent.
In this embodiment, as shown in fig. 1a to 1e, the fixing portion 11 further includes a central member 111, the supporting rods 14 are radially distributed from the central member 111 to the outside and sequentially include a proximal connecting rod 112, a middle branch rod 113, and a distal ring-shaped rod 114, the distal ring-shaped rod 114 is curved, or at least one segment thereof is parallel to the central axis of the central member 111 in the general direction; wherein the anchoring structures 2 are distributed in a fishbone shape at least on two side walls 143 of the distal loop bar 114, and the distance from the end of the anchoring structure 2 to the edge of the side wall 143 of the support bar 14 is not more than 1 mm.
In this embodiment, the support 13 is formed by laser engraving and heat setting the same shape memory alloy tube; when the insertion instrument 1 is in any state, any one of the anchoring structures 2 is on a plane tangent to the distal loop-shaped rod 114 at a point of tangency where the anchoring structure 2 meets the distal loop-shaped rod 114.
In this embodiment, the anchoring structures 2 are distributed on two side walls of the distal loop bar 114 in a fishbone shape, and when the implantation instrument 1 is in any state, any one of the anchoring structures 2 is on a plane, and the plane is tangent to the outer side of the distal loop bar 114 at a tangent point, which is a connection point where the anchoring structure 2 and the distal loop bar 114 meet.
In the present embodiment, as shown in fig. 2a to 2c, the overall shape structure of the anchoring structure 2 is a bull-horn type; wherein the length of the curve of each anchoring structure 2 is 0.2mm, 2mm, and the distance between adjacent anchoring structures 2 along the direction of the supporting rod 14 is 0.5mm, 2 mm.
In this example, the wall thickness of the tube material of the shape memory alloy tube was [0.15mm, 0.3mm ], and the outer diameter was [2mm, 4mm ].
In this embodiment, each anchoring structure 2 presents a gradually widening configuration from the far to the near from the supporting bar 14.
In this embodiment, the implantation instrument 1 and its delivery system comprise an isolation structure, which is at least partially located between the ends of all anchoring structures 2 and the inner wall of the delivery system when the implantation instrument 1 is loaded in the delivery system; when the implantation instrument 1 is placed in the target position in the cavity, the spacer structure is at least partially located inside the support bar 14 or inside the end of the anchoring structure 2; the distance from the end of the anchoring structure 2 to the edge of the side wall of the distal loop bar 114 is 0.2mm, 0.5 mm.
In this embodiment, the isolation structure is disposed on the implantation instrument within the interior of the distal loop rod 114.
In this embodiment, as shown in fig. 3a to 3e, the outer sides of the central member 111, the proximal joint rods 112 and the middle branch rods 113 are all connected with the flexible outer covering film 3, the inner side of the distal ring-shaped rod 114 is connected with the flexible inner covering film 31, and the outer covering film 31 is an isolation structure; wherein the outer cover film 3 and the inner cover film 31 may form an integral structure.
In this embodiment, the microstructure and the molding structure of each part of the integrated structure and the manufacturing method are the same.
In this embodiment, the coating film is one or more of a silicone film, a polyurethane film, a polyester film, a polytetrafluoroethylene film, a polyethylene film, a polypropylene film, a polylactic acid film, a polycaprolactone film, and a polyvinyl alcohol film.
In this embodiment, the outer cover film 3 and the inner cover film 31 are integrally formed by reverse insertion through the support 13.
In this embodiment, the cover film is fixed to the support body by sewing.
In this embodiment, the delivery system comprises a delivery sheath 4, a control handle 5, a cable 51, and a loader 52.
In this embodiment, the distal end of the anchoring structure 2 is directed proximally when the implantation instrument 1 is in its natural unconstrained state.
In this embodiment, the sealing portion 12 is provided with a three-dimensional film.
The operation procedure steps in the operation of the present embodiment are as follows (as shown in fig. 4a to 4 j):
(1) standard percutaneous vascular puncture is carried out at the femoral vein, a stiffened guide wire is placed, atrial septal puncture is carried out by using an atrial septal puncture kit, a femoral vein access is established, and the subsequent operations of stiffened guide wire exchange and establishment of a 4-way delivery sheath are completed;
(2) operating the control handle 5, pushing the delivery sheath 4 (containing the sheath core of the delivery sheath) into the left atrium along the stiffened guide wire in a retrograde manner through the femoral vein minimally-invasive opening, withdrawing the sheath core of the delivery sheath to the outside of the body, and reserving the delivery sheath 4 to provide a channel;
(3) placing the pigtail catheter along the stiffened guide wire to enable the pigtail catheter to reach the left upper pulmonary vein, withdrawing the stiffened guide wire, pulling the delivery sheath 4 and the pigtail catheter out of the left upper pulmonary vein integrally, slightly adjusting the position to enable the front end of the pigtail catheter to slide into the left auricle, pushing the delivery sheath 4 along the pigtail catheter to enable the delivery sheath 4 to reach the proximal position of the left auricle;
(4) withdrawing the pigtail catheter, forming a matched connection between the loader 52 provided with the left atrial appendage occluder and the delivery sheath 4 outside the body, pushing the steel cable 51, so that the left atrial appendage occluder gradually enters the delivery sheath 4 from the loader 52 under the pushing of the steel cable 51 and reaches the left atrial appendage until the fixing part 11 is pushed out of the delivery sheath 4, and the anchoring structure 2 on the fixing part 11 is jointed with the tissues in the left atrial appendage;
(5) the control handle 5 is continuously operated to enable the delivery sheath 4 to move towards the proximal end, the blocking part 12 restores to the preset shape, and the delivery system is retracted to complete the operation process.
Example two:
the present embodiment provides an implantation instrument with a fishbone-shaped anchoring structure and a delivery system thereof, which are different from the first embodiment in that:
in this embodiment, the isolation structure is provided on the delivery system, which further comprises a delivery sheath 4, a control handle 5, a cable 51, the isolation structure being able to be located between the delivery sheath 4 and said anchoring portion 11.
In this embodiment, as shown in fig. 5, the isolation structure is an isolation tube 6.
In this embodiment, the isolation structure is an isolation tube 6, the hardness of the inner surface of the isolation tube 6 is not lower than the hardness of the tail end of the anchoring structure, or the roughness of the inner surface of the isolation tube 6 is not higher than the roughness of the tail end of the anchoring structure; before the fixed part 11 does not return to the preset shape, the fixed part 11 and the isolating pipe 6 are kept relatively static in the axial direction; after the anchoring portion 11 has returned to the preset shape, the surgical procedure is completed after the delivery sheath 4 and the isolation tube 6 have been withdrawn simultaneously.
The operation procedure steps in the operation of the embodiment are as follows (as shown in fig. 3a to 3 i):
(1) standard percutaneous vascular puncture is carried out at the femoral vein, a stiffened guide wire is placed, atrial septal puncture is carried out by using an atrial septal puncture kit, a femoral vein access is established, and the subsequent operations of stiffened guide wire exchange and establishment of a 4-way delivery sheath are completed;
(2) operating the control handle 5, pushing the delivery sheath 4 (containing the sheath core of the delivery sheath) along the stiffened guide wire through the femoral vein minimally-invasive opening in a retrograde direction along the stiffened guide wire into the left atrium, withdrawing the sheath core 41 of the delivery sheath to the outside of the body, and reserving the delivery sheath 4 to provide a channel;
(3) placing the pigtail catheter along the stiffened guide wire to enable the pigtail catheter to reach the left upper pulmonary vein, withdrawing the stiffened guide wire, pulling the delivery sheath 4 and the pigtail catheter out of the left upper pulmonary vein integrally, slightly adjusting the position to enable the front end of the pigtail catheter to slide into the left auricle, pushing the delivery sheath 4 along the pigtail catheter to enable the delivery sheath 4 to reach the proximal position of the left auricle;
(4) withdrawing the pigtail catheter, forming a matched connection between the loader 52 provided with the left atrial appendage occluder and the delivery sheath 4 outside the body, operating the control handle 5 and pushing the steel cable 51 to ensure that the isolation tube 6 and the left atrial appendage occluder simultaneously enter the delivery sheath 4 from the loader 52 step by step and reach the left atrial appendage, continuing pushing the steel cable 51 until the fixing part 11 is pushed out of the isolation tube 6, and enabling the anchoring structure 2 on the fixing part 11 to be jointed with tissues in the left atrial appendage;
(5) the control handle 5 is continuously operated to enable the delivery sheath 4 and the isolation tube 6 to simultaneously move towards the proximal end, the blocking part 12 is restored to the preset shape, and the delivery system is retracted to complete the operation process.
Example three:
the difference between the implantation instrument with the fishbone-shaped anchoring structure and the delivery system thereof provided by the embodiment and the second embodiment is that:
in this embodiment, the isolation structure includes flexible membrane 7 and the detachable connection structure of wrapping up in, and the membrane 7 can cover all the terminal of anchoring structure 2 at least, and operation detachable connection structure wraps up in the membrane 7 and is unpacked apart for fixed part 11 is from wrapping up in the membrane 7 and exposing completely and radially expanding to predetermineeing the shape.
In this embodiment, as shown in fig. 6a, the conveying system further includes a control filament 8, the isolation structure is a wrapping film 7, a plurality of through holes are formed in the wrapping film 7, the plurality of through holes are spirally distributed, one end of the control filament 8 is arranged to pass through the plurality of through holes in sequence and then be detachable, the other end of the control filament 8 is connected with the control handle 5, when the fixing portion 11 reaches the expected release position, the control handle 5 is operated, one end of the control filament 8 is sequentially drawn out from the plurality of through holes to gradually release radial constraint on the wrapping film 7, and the fixing portion 11 is gradually radially expanded to the preset shape.
The steps of the operation process in the operation of the embodiment are as follows (as shown in fig. 6a to 6 d):
(1) standard percutaneous vascular puncture is carried out at the femoral vein, a stiffened guide wire is placed, atrial septal puncture is carried out by using an atrial septal puncture kit, a femoral vein access is established, and the subsequent operations of stiffened guide wire exchange and establishment of a 4-way delivery sheath are completed;
(2) operating the control handle 5, pushing the delivery sheath 4 (containing the sheath core of the delivery sheath) along the stiffened guide wire through the femoral vein minimally-invasive opening in a retrograde direction along the stiffened guide wire into the left atrium, withdrawing the sheath core of the delivery sheath to the outside of the body, and reserving the delivery sheath 4 to provide a channel;
(3) placing the pigtail catheter along the stiffened guide wire to enable the pigtail catheter to reach the left upper pulmonary vein, withdrawing the stiffened guide wire, pulling the delivery sheath 4 and the pigtail catheter out of the left upper pulmonary vein integrally, slightly adjusting the position to enable the front end of the pigtail catheter to slide into the left auricle, pushing the delivery sheath 4 along the pigtail catheter to enable the delivery sheath 4 to reach the proximal position of the left auricle;
(4) withdrawing the pigtail catheter, forming a matched connection between the loader 52 provided with the left atrial appendage occluder and the delivery sheath 4 outside the body, operating the control handle 5 and pushing the steel cable 51 to ensure that the flexible wrapping film 7 and the left atrial appendage occluder simultaneously enter the delivery sheath 4 from the loader 52 step by step and reach the left atrial appendage, continuing pushing the steel cable 51 until the fixing part 11 is pushed out of the delivery sheath 4, operating the control wire 8 to ensure that one end of the control wire 8 is sequentially drawn out from a plurality of perforations to gradually release radial constraint on the wrapping film 7, preferentially restoring the fixing part 11 to a preset shape, and jointing the anchoring structure 2 with tissues in the left atrial appendage;
(5) the control handle 5 is operated to move the delivery sheath 4 to the proximal end and simultaneously continue to operate the control wire to gradually release the radial constraint on the film wrapping, the blocking part 12 is restored to the preset shape, and the delivery system is retracted to finish the operation process.
The above description is only a preferred embodiment of the present invention, and for those skilled in the art, the present invention should not be limited by the description of the present invention, which should be interpreted as a limitation.
Claims (14)
1. An implant apparatus with a fishbone-shaped anchoring structure and a conveying system thereof are characterized in that: the implanting instrument at least comprises a fixing part, the fixing part comprises a supporting body, the supporting body comprises a plurality of elastic supporting rods and a plurality of anchoring structures, the supporting rods comprise inner sides, outer sides and side walls, and the anchoring structures are distributed on the side walls and/or the outer sides of the supporting rods in a fishbone shape;
when the implantation instrument is placed in a cavity, the distal end of the anchoring structure and the outer side of the support rod can contact the inner surface of the cavity and form a non-penetrating anchor.
2. The implant device and its delivery system with fishbone anchoring structure of claim 1, wherein: the anchoring structure is not elastically deformable relative to the supporting rod; and is
The supporting rods are radially distributed outwards from the central part and sequentially comprise near-end connecting rods, middle branch supporting rods and far-end ring-shaped rods, and the far-end ring-shaped rods are curved or at least one section of the far-end ring-shaped rods is parallel to the central axis of the central part in the general direction; wherein the content of the first and second substances,
the anchoring structures are distributed on the side wall of the far-end ring-shaped rod at least in a fishbone shape, and the distance from the tail ends of the anchoring structures to the edge of the side wall of the supporting rod is not more than 1 mm;
when the implantation instrument is in any state, any one of the anchoring structures is on a plane, and the plane and the distal ring-shaped rod are tangent to a tangent point, wherein the tangent point is a connection point where the anchoring structure and the distal ring-shaped rod are intersected.
3. The insertion instrument and its delivery system according to claim 2, wherein: the support body is formed by laser engraving and heat setting of the same shape memory alloy pipe; the anchoring structures are distributed on two side walls of the distal ring-shaped rod, and the overall shape structure of the anchoring structures is one or more combinations of a horn type, a two-fork type, a three-fork type, a four-fork type, a five-fork type and a wing type; wherein the content of the first and second substances,
the length of the curve of each anchoring structure is [0.2mm, 2mm ], and the distance between every two adjacent anchoring structures along the direction of the supporting rod is [0.5mm, 2mm ].
4. The implant device and its delivery system with fishbone anchoring structure of claim 1, wherein: each anchoring structure is gradually widened from far to near to the supporting rod.
5. The insertion instrument and its delivery system according to claim 2, wherein: the implantation instrument and its delivery system comprise an isolation structure; wherein
When the implantation instrument is loaded in the delivery system, the isolation structure is at least partially positioned between the distal ends of all of the anchoring structures and the inner wall of the delivery system;
the isolation structure is at least partially located within the medial side of the support rod or within a medial side of the distal end of the anchoring structure after the implantation instrument is placed in the cavity target location; the distance from the end of the anchoring structure to the distal loop-rod sidewall edge is [0.2mm, 0.5mm ].
6. The insertion instrument and its delivery system according to claim 5, wherein: the isolation structures are arranged on the implantation instrument and are distributed at the tail ends of the anchoring structures at intervals, or are positioned between two adjacent anchoring structures, or are positioned in the inner side of the distal ring-shaped rod, or the combination of the three; wherein the content of the first and second substances,
the isolation structure comprises one or more of a ball head, a salient point, a cutting head, a small ball and a filling thickened coating.
7. The insertion instrument and its delivery system according to claim 5, wherein: the outer sides of the self-centering piece, the near-end connecting rod and the middle branch rod are all connected with flexible outer covering films, the inner side of the far-end ring-shaped rod is connected with a flexible inner covering film, and the inner covering film is the isolating structure; wherein the content of the first and second substances,
the outer covering film and the inner covering film can form an integrated structure or a split type connecting structure.
8. The insertion instrument and its delivery system according to claim 7, wherein: the outer coating film and the inner coating film are the integrated structure formed by the support body being reversely inserted.
9. The insertion instrument and its delivery system according to claim 5, wherein: the isolation structure is disposed on the delivery system, the delivery system including an outer sheath and a control handle, the isolation structure being positionable between the outer sheath and the fixation portion.
10. The insertion instrument and its delivery system according to claim 9, wherein: isolation structure includes that the flexible membrane of wrapping up in and can dismantle connection structure, it can cover all at least to wrap up in the membrane the terminal of anchoring structure, the operation can dismantle connection structure, it is unpacked apart to wrap up in the membrane, makes the fixed part is followed expose completely in wrapping up in the membrane and radial expansion to predetermineeing the shape.
11. The insertion instrument and its delivery system according to claim 9, wherein: the isolation structure is an isolation pipe, the hardness of the inner surface of the isolation pipe is not lower than that of the tail end of the anchoring structure, or the roughness of the inner surface of the isolation pipe is not higher than that of the tail end of the anchoring structure;
before the fixed part is not restored to the preset shape, the fixed part and the isolating pipe are kept relatively static in the axial direction;
after the fixing part is restored to the preset shape, the outer sheath and the isolation tube are withdrawn simultaneously to complete the operation process.
12. The insertion instrument and its delivery system according to claim 5, wherein: the isolation structure is a second fixing part of a part of the implantation instrument, and the second fixing part is positioned on the inner side of the fixing part and is provided with the support body structure.
13. The insertion instrument and its delivery system according to claim 2, wherein: the fixing part comprises a reinforcing body, the reinforcing body comprises a plurality of elastic reinforcing rods, and at least one part of each reinforcing rod is in contact with the inner surface of the cavity; wherein
The reinforcing rod is formed by the self-center piece and/or the supporting rod which is dispersed outside the far end of the supporting body and then is free, the reinforcing rod comprises an inner face, an outer face and side faces, and the supporting body and the reinforcing body form a three-dimensional structure.
14. The insertion instrument and its delivery system according to claim 13, wherein: the tail end of the reinforcing rod is provided with a buffer structure, and the buffer structure comprises one or more of a circular ring, a ball head, a salient point and a rod width reducing structure; and the number of the first and second electrodes,
the reinforcing rod is provided with a plurality of anchoring structures, each anchoring structure comprises a fishbone and a hook, each hook is J-shaped, and the free end of each hook is far away from the central axis direction of the corresponding fixing part; a number of said anchoring structures are distributed on said lateral faces and/or on said outer faces of said reinforcing bars.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110600226.5A CN113749719A (en) | 2021-05-31 | 2021-05-31 | Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof |
| PCT/CN2022/089057 WO2022252878A1 (en) | 2021-05-31 | 2022-04-25 | Implantation device having fishbone-shaped anchoring structures and delivery system therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110600226.5A CN113749719A (en) | 2021-05-31 | 2021-05-31 | Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof |
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| CN113749719A true CN113749719A (en) | 2021-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110600226.5A Pending CN113749719A (en) | 2021-05-31 | 2021-05-31 | Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof |
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| Country | Link |
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| CN (1) | CN113749719A (en) |
| WO (1) | WO2022252878A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022252878A1 (en) * | 2021-05-31 | 2022-12-08 | 宁波迪创医疗科技有限公司 | Implantation device having fishbone-shaped anchoring structures and delivery system therefor |
| WO2024015335A1 (en) * | 2022-07-13 | 2024-01-18 | Boston Scientific Scimed, Inc. | Medical device for occluding a left atrial appendage |
| WO2024027761A1 (en) * | 2022-08-02 | 2024-02-08 | 先健科技(深圳)有限公司 | Left atrial appendage occluder |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374810A (en) * | 2018-12-29 | 2020-07-07 | 杭州唯强医疗科技有限公司 | Coated vascular stent with improved wall-adhering performance |
| EP3920810A4 (en) * | 2019-02-08 | 2022-11-09 | Conformal Medical, Inc. | Devices and methods for excluding the left atrial appendage |
| CN112022260A (en) * | 2020-07-28 | 2020-12-04 | 宁波迪创医疗科技有限公司 | Implanting instrument with bionic micro-thorn attaching structure |
| CN112155627A (en) * | 2020-07-28 | 2021-01-01 | 宁波迪创医疗科技有限公司 | Left auricle occluder with bionic micro-thorn attachment structure |
| CN112656461B (en) * | 2020-12-31 | 2022-09-02 | 先健科技(深圳)有限公司 | Plugging device |
| CN113749719A (en) * | 2021-05-31 | 2021-12-07 | 宁波迪创医疗科技有限公司 | Implanting instrument with fishbone-shaped anchoring structure and conveying system thereof |
-
2021
- 2021-05-31 CN CN202110600226.5A patent/CN113749719A/en active Pending
-
2022
- 2022-04-25 WO PCT/CN2022/089057 patent/WO2022252878A1/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022252878A1 (en) * | 2021-05-31 | 2022-12-08 | 宁波迪创医疗科技有限公司 | Implantation device having fishbone-shaped anchoring structures and delivery system therefor |
| WO2024015335A1 (en) * | 2022-07-13 | 2024-01-18 | Boston Scientific Scimed, Inc. | Medical device for occluding a left atrial appendage |
| WO2024027761A1 (en) * | 2022-08-02 | 2024-02-08 | 先健科技(深圳)有限公司 | Left atrial appendage occluder |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022252878A1 (en) | 2022-12-08 |
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