CN113749633B - Blood pressure calibration method and device, blood pressure measurement system and electronic equipment - Google Patents

Blood pressure calibration method and device, blood pressure measurement system and electronic equipment Download PDF

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CN113749633B
CN113749633B CN202110948089.4A CN202110948089A CN113749633B CN 113749633 B CN113749633 B CN 113749633B CN 202110948089 A CN202110948089 A CN 202110948089A CN 113749633 B CN113749633 B CN 113749633B
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calibration
blood pressure
calibration signal
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user
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CN113749633A (en
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不公告发明人
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Guangdong Transtek Medical Electronics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits

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Abstract

The invention provides a blood pressure calibration method, a blood pressure calibration device, a blood pressure measurement system and electronic equipment. Wherein the method is applied to a blood pressure measuring system, and comprises the following steps: applying pressure to a first part of a user through a first acquisition submodule; acquiring a first calibration signal generated by a first part of a user and a second calibration signal generated by a second part of the user; wherein, the calibration signal is a pulse wave sequence generated by a user in the process of applying pressure; and fusion-calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal. In the method, the calibration is carried out by adopting a plurality of signal sources such as the first calibration signal and the first calibration signal, so that the reliability and the precision of the blood pressure calibration can be improved.

Description

Blood pressure calibration method and device, blood pressure measurement system and electronic equipment
Technical Field
The invention relates to the technical field of medical treatment, in particular to a blood pressure calibration method, a blood pressure calibration device, a blood pressure measurement system and electronic equipment.
Background
Hypertension is the most common cardiovascular disease, which is more and more paid attention and concerned by people, and continuous blood pressure measurement is also an essential means for effectively monitoring the condition of hypertension. However, in general, continuous blood pressure measuring devices are calibrated at different times for each user, and a relationship between a measuring signal and the user is established.
One of the widely used blood pressure calibration methods is an oscillometric method used by an electronic sphygmomanometer, which blocks arterial blood flow through a cuff, detects an envelope of a pulsating oscillatory wave originating from a blood vessel wall during inflation and deflation, and finds out an inherent relationship between the envelope and arterial blood pressure to obtain calibrated blood pressure data.
However, the calibration using a single signal source is affected by the quality of the signal source and the accuracy of the blood pressure calculation method established based on the signal source, which results in low reliability.
Disclosure of Invention
In view of the above, the present invention provides a blood pressure calibration method, a blood pressure calibration device, a blood pressure measurement system, and an electronic apparatus, so as to improve the reliability and accuracy of blood pressure calibration.
In a first aspect, an embodiment of the present invention provides a blood pressure calibration method, which is applied to a blood pressure measurement system, and the method includes: applying pressure to a first part of a user through a first acquisition submodule; acquiring a first calibration signal generated by a first part of a user and a second calibration signal generated by a second part of the user; wherein, the calibration signal is a pulse wave sequence generated by a user in the process of applying pressure; and fusion-calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
In the preferred embodiment of the present application, the first portion and the second portion are located on the ipsilateral arm or the contralateral arm; if the first part and the second part are positioned on the arm at the same side, the first part is arranged at the position of the artery at the heart end of the arm at the same side, and the second part is arranged at the position of the artery at the heart end of the arm at the same side; if the first part and the second part are positioned on the arms on different sides, the first part and the second part are respectively arranged at the artery blood vessels of the arms on different sides.
In a preferred embodiment of the present application, the step of fusion-calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal includes: if the first part and the second part are positioned on the arm on the same side, performing bidirectional fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user; and if the first part and the second part are positioned on the arms on different sides, performing one-way fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user.
In a preferred embodiment of the present application, the step of performing the uni-directional fusion calculation on the first calibration signal and the second calibration signal includes: determining a characteristic of the first calibration signal and a characteristic of the second calibration signal; wherein the features at least include: calibrating the time of the main wave crest of each pulse wave in the signal; deleting invalid pulse waves in the first calibration signal based on the characteristics of the first calibration signal; deleting invalid pulse waves in the second calibration signal based on the characteristics of the second calibration signal; and if the first main wave crest moment of the first calibration signal lacks the second main wave crest moment, reconstructing the missing characteristic corresponding to the second main wave crest moment based on the characteristics of a plurality of second calibration signals before and after the first main wave crest moment.
In a preferred embodiment of the present application, the step of performing bidirectional fusion calculation on the first calibration signal and the second calibration signal includes: determining a characteristic of the first calibration signal and a characteristic of the second calibration signal; is characterized by comprising the following steps: calibrating the time of a main wave crest, the amplitude of the main wave, the start time of the main wave and the end time of the main wave of each pulse wave in the signal; compensating the first calibration signal based on characteristics of the second calibration signal; compensating the second calibration signal based on the characteristic of the first calibration signal; a first signal quality of the first calibration signal and a second signal quality of the second calibration signal are calculated based on the compensated characteristics of the first calibration signal and the compensated characteristics of the second calibration signal.
In a preferred embodiment of the present application, the step of compensating the second calibration signal based on the characteristics of the first calibration signal comprises: if the first main wave crest moment of the first calibration signal lacks the second main wave crest moment, reconstructing the missing characteristic corresponding to the second main wave crest moment based on the characteristics of a plurality of second calibration signals before and after the first main wave crest moment; the step of compensating the first calibration signal based on the characteristics of the second calibration signal comprises: and if the second main wave crest moment of the second calibration signal lacks the first main wave crest moment, reconstructing the missing characteristic corresponding to the first main wave crest moment based on the characteristics of a plurality of first calibration signals before and after the second main wave crest moment.
In a preferred embodiment of the present application, the method further comprises: based on the characteristics of the first calibration signal, the average pressure measurement value MAP and the first systolic pressure measurement value SBP of the user are determined by adopting a variable amplitude coefficient method 1 And a first diastolic measurement DBP 1 (ii) a If the calculation is a two-way fusion, a second systolic measurement SBP is calculated based on the characteristics of the second calibration signal 2 (ii) a Inputting the characteristic of the second calibration signal and the mean pressure measurement MAP into a preset second diastolic model to obtain a second diastolic measurement DBP 2 。
In a preferred embodiment of the present application, the second systolic measurement SBP is calculated on the basis of the characteristics of the second calibration signal 2 Step (a) ofThe method comprises the following steps: the pressure corresponding to the arterial vessel blockage time in the inflation type measurement or the arterial vessel opening time in the deflation type measurement is taken as a second systolic pressure measurement value SBP 2 (ii) a The arterial vessel occlusion time is a stable starting time when the dominant wave amplitude of the second calibration signal changes from large to small with time and becomes stable; the opening time of the artery blood vessel is the stable ending time when the main wave amplitude of the second calibration signal is changed from stable to small to large along with the time.
In a preferred embodiment of the present application, the blood pressure calibration values comprise a calibrated systolic pressure and a calibrated diastolic pressure; the step of determining the blood pressure calibration value of the user further comprises the following steps: if the calculation is one-way fusion, the first systolic pressure measurement value SBP is calculated 1 As a calibration systolic pressure, a first diastolic pressure measurement DBP is taken 1 As a calibrated diastolic pressure; if the calculation is bidirectional fusion calculation, the first signal quality and the second signal quality are used as weights, and the first systolic pressure measurement value SBP is used 1 And a second systolic blood pressure measurement SBP 2 As a calibrated systolic pressure, the first diastolic pressure measurement DBP 1 And a second diastolic pressure measurement DBP 2 The weighted average of (a) is used as the calibrated diastolic pressure.
In a preferred embodiment of the present application, the blood pressure calibration value includes a calibrated diastolic blood pressure and a calibrated systolic blood pressure, and after the step of calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal, the method further includes: acquiring a corrected signal of a user; the corrected signal is a pulse wave sequence generated by the user; acquiring physiological parameters of the user based on the corrected signals, and updating a physiological parameter blood pressure model of the user based on the calibrated diastolic pressure, the calibrated systolic pressure and the physiological parameters, wherein the physiological parameter blood pressure model is used for calculating the current blood pressure value of the user according to the physiological parameters; the physiological parameter includes at least one of: the height, age, sex, body mass index BMI, arm circumference and wrist circumference information of the user, and the corrected signal at least comprises one of the following information: pulse wave velocity information, pulsatile blood volume change information, or heart rate information.
In a preferred embodiment of the present application, the step of updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter comprises: if the wearing detection condition and the effective calibration time window condition are both satisfied, updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter; the wearing detection condition represents that the direct current component of the corrected signal reaches a preset amplitude value, and the frequency spectrum distribution of the alternating current component is matched with the preset distribution; the effective calibration time window condition represents that the acquisition time of the calibrated signal and the occurrence time of the blood pressure calibration value accord with a preset time length relation.
In a preferred embodiment of the present application, the step of updating the physiological parameter blood pressure model of the user based on the calibrated diastolic pressure, the calibrated systolic pressure and the physiological parameter further comprises: comparing at least one parameter of pulse wave velocity information, pulse blood volume change information or heart rate information with the same type of parameters of a physiological parameter blood pressure model of a user to obtain a comparison result; and if the comparison result exceeds a preset reference proportion, updating the physiological parameter blood pressure model of the user.
In a second aspect, an embodiment of the present invention further provides a blood pressure calibration device, which is applied to a blood pressure measurement system, and the device includes: the first part pressure applying module is used for applying pressure to a first part of a user through the first acquisition submodule; the calibration signal acquisition module is used for acquiring a first calibration signal generated by a first part of a user and a second calibration signal generated by a second part of the user; the calibration signal is a pulse wave sequence generated by a user in the pressurizing process; and the blood pressure calibration value calculation module is used for fusion calculation of the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
In a third aspect, an embodiment of the present invention further provides a blood pressure measurement system, including: a calibration unit and a measurement body; the calibration unit is used for calculating a blood pressure calibration value based on multi-channel pulse wave signal fusion and sending the blood pressure calibration value to the measurement main body; the measurement main body is used for updating the physiological parameter blood pressure model of the user according to the blood pressure calibration value and calculating the current blood pressure value of the user according to the updated physiological parameter blood pressure model and the current physiological parameter of the user.
In a preferred embodiment of the present application, the calibration unit includes: the calibration pulse wave acquisition module, the calibration processor, the calibration communication module and the calibration storage module; the calibration pulse wave acquisition module comprises a first acquisition submodule and a second acquisition submodule; the first acquisition submodule comprises an electronic sphygmomanometer based on inflatable measurement or deflating measurement and is used for acquiring a first calibration signal; the second acquisition submodule includes at least one of: the second acquisition submodule is used for acquiring a second calibration signal; the second acquisition sub-module is separated from the calibration unit in a wireless or wired mode and at least comprises an accelerometer or a gyroscope, and the second acquisition sub-module is also used for judging whether a user is in a stable state or not when acquiring the first calibration signal and the second calibration signal; the calibration processor is used for fusing the first calibration signal and the second calibration signal and calculating a blood pressure calibration value; the calibration communication module is connected with the calibration processor and is used for sending the blood pressure calibration value, the generation time of the blood pressure calibration value and a calibration instruction to the measurement main body; the calibration storage module is connected with the calibration processor and used for storing the blood pressure calibration value and the occurrence time of the blood pressure calibration value.
In a preferred embodiment of the present application, the measurement body includes: the device comprises a main body pulse wave acquisition module, a main body processor, a main body storage module and a main body communication module;
the main body pulse wave acquisition module at least comprises one of the following modules: the device comprises a photoelectric plethysmograph, a laser radar, an optical imaging, a piezoelectric capacitor and an electrocardio sensor, wherein a main body pulse wave acquisition module is used for acquiring a corrected signal; the main body pulse wave acquisition module at least comprises an accelerometer or a gyroscope and is used for judging whether the user is in a stable state or not when the corrected signal is acquired; the main body communication module is used for receiving the blood pressure calibration value and sending a calibration instruction to the calibration unit; the main body storage module is used for storing a physiological parameter blood pressure model, and storing a blood pressure calibration value, the occurrence time of the blood pressure calibration value and a physiological parameter; the main body processor is used for updating the physiological parameter blood pressure model according to the blood pressure calibration value; and calculating the current blood pressure value of the user according to the updated physiological parameter blood pressure model and the current physiological parameter of the user.
In a preferred embodiment of the present application, the measurement body comprises a second acquisition submodule for providing a second calibration signal, if the second acquisition submodule is separate from the calibration unit.
The embodiment of the invention has the following beneficial effects:
according to the blood pressure calibration method, the blood pressure calibration device, the blood pressure measurement system and the electronic equipment provided by the embodiment of the invention, the blood pressure calibration value of a user is calculated in a fusion manner based on a first calibration signal generated by a first part and a second calibration signal generated by a second part; and updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter of the user. In the method, the calibration is carried out by adopting a plurality of signal sources such as the first calibration signal and the first calibration signal, so that the reliability and the precision of the blood pressure calibration can be improved.
Additional features and advantages of the disclosure will be set forth in the description which follows, or in part may be learned by the practice of the above-described techniques of the disclosure, or may be learned by practice of the disclosure.
In order to make the aforementioned objects, features and advantages of the present disclosure more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural diagram of a blood pressure measuring system according to an embodiment of the present invention;
fig. 2 is a detailed structural diagram of a blood pressure measuring system according to an embodiment of the present invention;
FIG. 3 is a flow chart of a blood pressure calibration method according to an embodiment of the present invention;
FIG. 4 is a flow chart of another blood pressure calibration method according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of a blood pressure measurement system according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of another blood pressure measurement system provided by an embodiment of the present invention;
FIG. 7 is a schematic view of another blood pressure measuring system provided by an embodiment of the present invention;
FIG. 8 is a schematic diagram of a pulse waveform according to an embodiment of the present invention;
FIG. 9 is a schematic overall flowchart of a blood pressure calibration method according to an embodiment of the present invention;
FIG. 10 is a schematic structural diagram of a blood pressure calibration device according to an embodiment of the present invention;
fig. 11 is a schematic structural diagram of an electronic device according to an embodiment of the present invention.
Icon:
301-a correction unit; 302-a first acquisition submodule; 303-cuff; 304-function keys; 305-a display screen; 306-a micro laser source; 307-a photodiode; 308-a second acquisition submodule; 309-measuring the subject; 310-a micro laser source; 311-a photodiode; 312 — a first electrode; 313-a second electrode; 314-a third electrode; 315-a correction unit; 316-a first acquisition submodule; 317-a cuff; 318-gas path; 319-function buttons; 320-a display screen; 321-a second acquisition submodule; 323-micro laser source; 324-a photodiode; 325-electrocardio signals; 326 — a measurement subject; 327-a micro laser source; 328-a photodiode; 329-a first electrode; 330-a second electrode; 331-a third electrode; 332-correction unit.
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
At present, a single signal source is generally used for blood pressure calibration in blood pressure measurement, and the reliability is low due to the influence of the quality of the signal source and the influence of the precision of a blood pressure calculation method established based on the signal source. Based on this, the embodiment of the invention provides a blood pressure calibration method, a blood pressure calibration device, a blood pressure measurement system and an electronic device, and particularly relates to a blood pressure calibration device and a blood pressure calibration method which integrate multiple calibration signals, so that the reliability of blood pressure measurement is improved, and the accuracy of blood pressure measurement is further improved.
For the convenience of understanding the present embodiment, a detailed description will be given to a blood pressure calibrating method disclosed in the present embodiment.
The first embodiment is as follows:
an embodiment of the present invention provides a blood pressure measuring system, which is shown in fig. 1, and includes: a calibration unit and a measurement body; the calibration unit is used for calculating a blood pressure calibration value based on multi-channel pulse wave signal fusion and sending the blood pressure calibration value to the measurement main body; the measurement main body is used for updating the physiological parameter blood pressure model of the user according to the blood pressure calibration value and calculating the current blood pressure value of the user according to the updated physiological parameter blood pressure model and the current physiological parameter of the user.
The blood pressure measuring system of the embodiment is calibrated based on the blood pressure of an individual to measure the blood pressure, and comprises a calibration unit and a measuring main body. Referring to fig. 2, a detailed structural diagram of a blood pressure measuring system is shown; the calibration unit comprises a calibration pulse wave acquisition module, a calibration processor and a calibration communication module; wherein, calibration pulse ripples collection module includes first collection module and second collection module.
The first acquisition submodule is used for acquiring a first calibration signal. For example, the first acquisition sub-module refers to an electronic sphygmomanometer with inflatable or deflatable measurement. Therefore, the first calibration signal is a pressure pulse wave signal obtained when the cuff or the wrist strap of the electronic sphygmomanometer applies pressure to the radial artery or brachial artery of the wrist of the user.
The second acquisition submodule includes at least one of: the photoelectric volume scanning meter, the laser radar, the optical imaging and the piezoelectric/capacitive sensor are used for acquiring a second calibration signal; in general, the second self-collecting module is preferably a photoelectric plethysmograph sensor; the second calibration signal is therefore a photoplethysmograph signal.
The second acquisition sub-module can be separated from the calibration unit in a wireless or wired manner, and at least comprises one of the following motion sensors: the accelerometer and the gyroscope are used for judging whether the user is in a stable state or not when the first calibration signal and the second calibration signal are acquired; generally, the motion sensor is preferably an accelerometer, and based on whether the standard deviation of any one axis signal per second in three axis signals provided by the accelerometer exceeds a preset motion amount threshold value in the acquisition process, and the time length of exceeding the preset motion amount threshold value is accumulated to a preset unstable time length, the acquisition process can be stopped;
the calibration processor is used for fusing the first calibration signal and the second calibration signal and calculating a blood pressure calibration value; the calibration communication module is connected with the calibration processor and used for sending the blood pressure calibration value to the measurement main body.
As shown in fig. 2, the measurement main body includes a main body pulse wave acquisition module, a main body processor, a main body storage module and a main body communication module; the main body pulse wave acquisition module at least comprises one of the following modules: the photoelectric volume plotter, the laser radar, the optical imaging, the piezoelectric/capacitor and the electrocardio sensor are used for acquiring a measured signal to be corrected; generally, the subject pulse wave acquisition module includes two or more sensors. For example, the sensor comprises a photoelectric volume plotter and an electrocardio-sensor, a photoelectric volume plotter and a laser radar sensor, or two photoelectric volume plotter sensors; accordingly, the corrected signal also comprises two signals which are measured simultaneously.
The main body pulse wave acquisition module at least comprises an accelerometer and a gyroscope and is used for judging that a user is in a stable state when acquiring and measuring pulse wave signals; for example, when the user is in a non-stationary state, the user is prompted to hold a correct measurement posture or to terminate the measurement;
the main body communication module is used for receiving the blood pressure calibration value; meanwhile, the main body communication module and the calibration communication module carry out information interaction, and the main body communication module sends a calibration instruction to the calibration communication module, or the calibration communication module sends a calibration instruction to the main body communication module, so as to start a calibration process;
and the main body storage module is used for storing the physiological parameter blood pressure model. Preferably, the blood pressure calibration value received last time and the occurrence time of the blood pressure calibration value may be stored. The main body processor is used for processing the corrected signals, extracting physiological parameters and calibrating a physiological parameter blood pressure model according to a blood pressure calibration value; and calculating a blood pressure value according to the physiological parameter blood pressure model.
Furthermore, if the second acquisition submodule is separate from the calibration unit, the measurement body is equivalent to the second acquisition submodule for providing a second calibration signal.
To sum up, the embodiment of the present invention provides a blood pressure measuring system, which includes a calibration unit and a measuring main body, wherein: the calibration unit is used for calculating a blood pressure calibration value based on multi-channel pulse wave signal fusion and is provided for the measurement main body to finish blood pressure calibration and blood pressure measurement of the user; the measurement main body carries out blood pressure measurement based on the corrected signal, calibrates the physiological parameter blood pressure model according to the blood pressure calibration value provided by the calibration unit, and calculates the blood pressure value of the user according to the physiological parameter blood pressure model. The calibration process of the physiological parameter blood pressure model is automatically completed by the blood pressure measuring system, and the measurement main body measures the physiological parameters of the user after calibration and calculates the blood pressure value according to the correction model, so that the accurate measurement of the blood pressure is realized, and the accuracy of the blood pressure measurement can be improved.
Example two:
an embodiment of the present invention provides a blood pressure calibration method, which is applied to a blood pressure measurement system, and is shown in a flowchart of a blood pressure calibration method shown in fig. 3, where the blood pressure calibration method includes the following steps:
step S302, a first part of the user is pressed through the first acquisition submodule.
The blood pressure calibration method in this embodiment can be applied to the blood pressure calibration system provided in the above embodiment, and is used to update the physiological parameter blood pressure model of the blood pressure calibration system. The current physiological parameter of the user can be input into the updated physiological parameter blood pressure model, and the current blood pressure value of the user is output.
The first acquisition sub-module may be an electronic sphygmomanometer, the first location may be a proximal arterial vessel of the user, and the electronic sphygmomanometer may be used to apply pressure to the proximal arterial vessel of the user.
Step S304, a first calibration signal generated by a first part of the user and a second calibration signal generated by a second part of the user are obtained.
The calibration signal in this embodiment may be a pulse wave sequence generated by a user during the pressing process; when the first acquisition submodule acquires the applied pressure, a first calibration signal generated by a first part of a user can be acquired; a second calibration signal generated at a second location of the user may be acquired when the second acquisition sub-module acquires the applied pressure.
The first part and the second part have two setting modes, namely a same-side arm setting and a different-side arm setting. The first position and the second position can be arranged in different ways.
And S306, fusing and calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
Specifically, different setting manners, the manner of performing the fusion calculation on the first calibration signal and the second calibration signal may be different, for example: the fusion calculation comprises one-way fusion and two-way fusion; wherein, the unidirectional fusion is based on the different side arm arrangement, and the bidirectional fusion is based on the same side arm arrangement. Further, the blood pressure calibration may include calibrating the systolic pressure and calibrating the diastolic pressure.
After obtaining the blood pressure calibration value, the physiological parameter blood pressure model of the user may be updated with the obtained blood pressure calibration value, for example: and acquiring the physiological parameters of the user, and updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameters.
The physiological parameters may include at least height, age, gender, body mass index BMI, arm circumference, wrist circumference information of the user, and pulse wave velocity information, pulsatile blood volume change information or heart rate information obtained from the corrected signals. After the physiological parameters are obtained, the physiological parameter blood pressure model of the user can be updated according to the blood pressure calibration value and the physiological parameters, so that the updated physiological parameter blood pressure model has higher blood pressure monitoring accuracy.
According to the blood pressure calibration method provided by the embodiment of the invention, the blood pressure calibration value of a user is calculated based on a first calibration signal generated by a first part and a second calibration signal generated by a second part in a fusion manner; and updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter of the user. In the method, a plurality of signal sources such as the first calibration signal and the second calibration signal are adopted for calibration, so that the reliability and the precision of blood pressure calibration can be improved.
Example three:
the present embodiment provides another blood pressure calibration method, which is implemented on the basis of the above embodiments, and as shown in a flowchart of another blood pressure calibration method shown in fig. 4, the blood pressure calibration method in the present embodiment includes the following steps:
step S402, pressing a first part of the user through the first acquisition submodule.
In step S404, a first calibration signal generated by a first portion of the user and a second calibration signal generated by a second portion of the user are obtained.
Specifically, the first part and the second part are positioned on the same side arm or different side arms; if the first part and the second part are positioned on the arm at the same side, the first part is arranged at the position of the artery at the heart end of the arm at the same side, and the second part is arranged at the position of the artery at the heart end of the arm at the same side; if the first part and the second part are positioned on the arms on different sides, the first part and the second part are respectively arranged at the artery blood vessels of the arms on different sides.
Referring to fig. 5, in a schematic diagram of a blood pressure measuring system, in a correction unit 301 of the present embodiment, a first acquisition sub-module 302 is an arm type electronic sphygmomanometer with an integrated cuff and a host, and can acquire a first calibration signal by using an inflatable or deflatable measurement manner, which includes a cuff 303, a display screen 305, and function buttons 304. Therefore, the first calibration signal is a pressure pulse wave signal. The second acquisition sub-module 308 is a photoplethysmograph sensor that contains a micro laser source 306 and a photodiode 307. The second acquisition submodule 308 is designed to be integrated with the correction unit and is mounted at the distal end of the cuff 303. Therefore, the second calibration signal is the photoplethysmograph pulse wave signal.
As shown in fig. 5, the measurement subject 309 in this embodiment is a wrist device, and incorporates a photoplethysmograph sensor and an electrocardiograph sensor. The photoplethysmograph sensor is used for acquiring pulse wave signals of the photoplethysmograph, and comprises a micro laser source 310 and a photodiode 311. The electrocardio-sensor is provided with three electrodes on the surface of the body of the measuring main body, namely a first electrode 312, a second electrode 313 and a third electrode 314. The first electrode 312 is used as a driving electrode, i.e., an RLD electrode, and the second electrode 313 and the third electrode 314 are used as detection electrodes, i.e., an LA electrode and an RA electrode, respectively. When acquiring the measurement pulse wave signal, the user needs to press the RA electrode between the left hand. The LA electrode, the sensing electrode, and the photoplethysmograph sensor will be in close proximity to the skin. The electrocardiosignal in the measuring main body and the pulse wave signal of the photoelectric plethysmograph are synchronously collected to form a corrected signal.
When a user performs measurement, the measurement subject 309 may issue a calibration instruction, and after the correction unit 301 (which may also be referred to as a calibration unit) acquires a blood pressure calibration value, the calibration unit returns to the measurement subject 309. The measurement subject 309 updates the physiological parameter blood pressure model according to the blood pressure calibration value.
Referring to fig. 6, in another schematic diagram of a blood pressure measuring system, in the correcting unit 315 of the present embodiment, the first collecting sub-module 316 is an electronic sphygmomanometer with a cuff and a host separated, and the first calibrating signal is obtained by using an inflatable or an deflatable measuring method, and includes a cuff 317, an air passage 318, a display screen 320, and function keys 319. The second acquisition submodule 321 is a photoplethysmograph sensor that includes a micro laser source 323 and a photodiode 324.
In some cases, the method shown in fig. 6 may not be able to compensate each other because the first calibration signal and the second calibration signal have invalid pulse waves or invalid pulse waves at the same time. Such as slight shaking during the user's measurement, weak perfusion with insufficient cuff pressure pressurization, etc. Further, other physiological signals acquired synchronously may be added. For example, the electrocardiographic signal 325 can be used not only to further determine an ineffective pulse wave or an ineffective pulse wave, but also to calculate parameters such as Pulse Wave Transit Time (PWTT) in accordance with the existing second pulse wave signal. The newly added parameters may further be incorporated into the calculation of Diastolic (DBP) and Systolic (SBP) pressures.
The measurement body 326 shown in fig. 6 is the same as that shown in fig. 5, and includes a micro laser source 327, a photodiode 328, a first electrode 329, a second electrode 330, and a third electrode 331.
Referring to another schematic diagram of the blood pressure measuring system shown in fig. 7, the calibration unit 332 in this embodiment may be equivalent to the second calibration signal in some possible ways.
And step S406, fusing and calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
Specifically, the fusion calculation mode includes one-way fusion calculation and two-way fusion calculation, and the fusion calculation mode corresponds to the position relationship between the first part and the second part. For example: the unidirectional fusion is based on the different-side arm setting, and the bidirectional fusion is based on the same-side arm setting; the fusion calculation can be performed by:
if the first part and the second part are positioned on the arm on the same side, performing bidirectional fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user; and if the first part and the second part are positioned on the arms on different sides, performing one-way fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user.
Specifically, the one-way fusion calculation can be performed by the following steps: a characteristic of the first calibration signal and a characteristic of the second calibration signal are determined. Wherein the features at least include: calibrating the time of the main wave crest of each pulse wave in the signal; the first calibration signal is compensated based on characteristics of the second calibration signal.
It should be noted here that the characteristics of the calibration signal may include: the main wave starting time, the main wave crest time, the main wave amplitude, the central isthmus descending time, the dicrotic wave crest time, the dicrotic wave amplitude, the dicrotic wave ending time and the like of each pulse wave in the calibration signal.
Compensation here can be understood as deleting the invalid pulse waves in the calibration signal, after which the features of the missing pulse wave portions are reconstructed using the valid pulse waves. For example: the step of compensating the first calibration signal based on the characteristics of the second calibration signal comprises: deleting invalid pulse waves in the first calibration signal based on the characteristics of the first calibration signal; deleting invalid pulse waves in the second calibration signal based on the characteristics of the second calibration signal; and if the first main wave crest moment of the first calibration signal lacks the second main wave crest moment, reconstructing the missing characteristic corresponding to the second main wave crest moment based on the characteristics of a plurality of second calibration signals before and after the first main wave crest moment.
The method for determining the validity of any pulse wave can refer to, but is not limited to, the following formula:
QL-1.5×IQR≤F≤QU+1.5×IQR；
wherein F is the amplitude of the main wave peak, QL and QU are the lower quartile and the upper quartile of the distribution formed by the same type features of all the pulse waves, and IQR is the interquartile distance. Further, it may be referred to whether a plurality of features satisfy the above formula at the same time.
The reference for the absence may be whether the pulse wave is absent at the time corresponding to the non-ineffective pulse wave. If the absence is determined, the feature of the corresponding pulse wave can be reconstructed by referring to, but not limited to, the following formula, taking the reconstruction of the dominant wave amplitude a (t) at time t as an example:
Figure BDA0003217545390000141
Δ i ＝A(i)-A(i-1)；
the step of bi-directional fusing comprises uni-directional fusing and further comprises compensating the second calibration signal based on a characteristic of the first calibration signal. Therefore, the step of performing a bidirectional fusion calculation on the first calibration signal and the second calibration signal comprises: determining a characteristic of the first calibration signal and a characteristic of the second calibration signal; is characterized by comprising the following steps: calibrating the time of a main wave crest, the amplitude of the main wave, the start time of the main wave and the end time of the main wave of each pulse wave in the signal; compensating the first calibration signal based on characteristics of the second calibration signal; compensating the second calibration signal based on the characteristic of the first calibration signal; a first signal quality of the first calibration signal and a second signal quality of the second calibration signal are calculated based on the compensated characteristics of the first calibration signal and the compensated characteristics of the second calibration signal.
Specifically, the signal quality of the first calibration signal and the second calibration signal can be calculated according to the characteristics and the invalid ratio of the calibration signal, and can refer to, but not limited to, the following formula:
ω＝Q×CV F ；
Figure BDA0003217545390000151
Figure BDA0003217545390000152
wherein Q is the invalid ratio of the first calibration signal and the second calibration signal, CV F For selected characteristics, e.g. coefficient of variation at the time of the main wave peak, (F) i+1 -F i ) ω represents the signal quality with the interval duration of the adjacent main wave peak time as a reference.
Specifically, the step of compensating the second calibration signal based on the characteristics of the first calibration signal comprises: if the first main wave crest moment of the first calibration signal lacks the second main wave crest moment, reconstructing the missing characteristic corresponding to the second main wave crest moment based on the characteristics of a plurality of second calibration signals before and after the first main wave crest moment;
the step of compensating the first calibration signal based on characteristics of the second calibration signal comprises: and if the second main wave crest moment of the second calibration signal lacks the first main wave crest moment, reconstructing the missing characteristic corresponding to the first main wave crest moment based on the characteristics of a plurality of first calibration signals before and after the second main wave crest moment.
Preferably, the amplitude coefficient method can be adopted to determine the average pressure measured value MAP and the first systolic pressure measured value SBP of the user 1 And a first diastolic measurement DBP 1 . Different fusion calculation methods are different in the way of calculating the blood pressure calibration value of the user. For example: if the calculation is a two-way fusion, a second systolic measurement SBP is calculated based on the characteristics of the second calibration signal 2 (ii) a Inputting the characteristic of the second calibration signal and the mean pressure measurement MAP into a preset second diastolic model to obtain a second diastolic measurement DBP 2 。
Wherein, the pressure corresponding to the arterial vessel blocking time in the inflation type measurement or the arterial vessel opening time in the deflation type measurement can be used as the second systolic pressure measurement value SBP 2 (ii) a The arterial vessel occlusion time is a stable starting time when the dominant wave amplitude of the second calibration signal changes from large to small with time and becomes stable; the opening time of the artery blood vessel is the stable ending time when the main wave amplitude of the second calibration signal is changed from stable to small to large along with the time.
For example, in this example, the start time point after the main wave amplitude of the pulse wave of the second calibration signal tends to be stable may be selected. After this point, no further change in the amplitude of the main wave occurs. For the judgment that the amplitude of the main wave does not change any more, it can be referred to, but not limited to, that the amplitudes of adjacent 4 main waves all satisfy less than or equal to 0.1 times of all the amplitudes of the main waves in the past;
in a preferred embodiment of the present invention, the characteristic of the second calibration wave signal and the average pressure measurement MAP are input into a predetermined second diastolic pressure model to obtain a second diastolic pressure measurement DBP 2 (ii) a Second diastolic pressure DBP 2 The following formula can be used for the calculation of (c):
DBP 2 ＝(MAP-a×SBP 2 )/b；
Figure BDA0003217545390000161
Figure BDA0003217545390000162
wherein, t s (i) Generally, the duration of the systolic period is represented by the time length from the time of the main wave start of the ith pulse wave to the time of the strait, see a pulse wave waveform diagram shown in fig. 8, i.e., the time length from point a (the time of the main wave start) to point C (the time of the strait) in fig. 8. td (i) is the time length from the isthmus falling time to the dicrotic wave ending time of the ith pulse wave, and generally represents the diastolic time length, i.e., the time length from point C (isthmus falling time) to point E (dicrotic wave ending time) in fig. 8. N is the pulse wave number in the second pulse wave signal.
Furthermore, the blood pressure calibration value comprises a calibrated systolic pressure and a calibrated diastolic pressure, and if calculated in a one-way fusion, the first systolic pressure measurement value SBP is used 1 As a calibration systolic pressure, a first diastolic pressure measurement DBP is taken 1 As a calibrated diastolic pressure; if the calculation is bidirectional fusion calculation, the first signal quality and the second signal quality are used as weights, and the first systolic pressure measurement value SBP is used 1 And a second systolic blood pressure measurement SBP 2 As a calibrated systolic pressure, the first diastolic pressure measurement DBP 1 And a second diastolic pressure measurement DBP 2 The weighted average of (a) is used as the calibrated diastolic pressure.
After obtaining the blood pressure calibration value of the user, the physiological parameter blood pressure model of the user can be updated by the following steps: acquiring a calibrated signal of a user; the corrected signal is a pulse wave sequence generated by the user; and acquiring the physiological parameters of the user based on the corrected signals, and updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameters.
Wherein the physiological parameter includes at least one of: the height, age, sex, body mass index BMI, arm circumference and wrist circumference information of the user, and the corrected signal at least comprises one of the following information: pulse wave velocity information, pulsatile blood volume change information, or heart rate information.
The physiological parameter blood pressure model of the user can be updated only if it is determined that both the wearing detection condition and the effective calibration time window condition are satisfied. The wearing detection condition represents that the direct current component in the corrected signal reaches a preset amplitude value, and the frequency spectrum distribution of the alternating current component is matched with the preset distribution; the effective calibration time window condition represents that the acquisition time of the pulse wave signal and the occurrence time of the received blood pressure calibration value accord with a preset time length relation.
The physiological parameters may comprise pulse wave velocity information, pulsatile blood volume change information or heart rate information and height, age, sex, body mass index BMI, arm circumference, wrist circumference information of the user. For example: the step of acquiring physiological parameters of a user comprises: acquiring pulse wave velocity information, pulse blood volume change information or heart rate information from one or more pulse wave signals, and including height, age, sex, body mass index BMI, arm circumference or wrist circumference information of the user.
Since the blood pressure calibration value comprises the calibrated systolic pressure and the calibrated systolic pressure, the physiological parameter blood pressure model of the user can be updated based on the calibrated diastolic pressure, the calibrated systolic pressure and the physiological parameter.
Specifically, if at least one parameter of pulse wave velocity information, pulse blood volume change information or heart rate information is compared with the same type of parameters of a physiological parameter blood pressure model of the user, a comparison result is obtained; and if at least one comparison result exceeds a preset reference proportion, updating the physiological parameter blood pressure model of the user.
The updated physiological parameter blood pressure model is used for calculating the current blood pressure value of the user according to the received current physiological parameter. That is, after the physiological parameter blood pressure model is updated, the current physiological parameter of the user can be acquired, and the current physiological parameter is input into the updated physiological parameter blood pressure model, and the updated physiological parameter blood pressure model can output the current blood pressure value of the user, that is, the current systolic pressure measurement value and the current diastolic pressure measurement value of the user.
In summary, the overall flow of the blood pressure calibration method provided in this embodiment can be seen from the overall flow diagram of the blood pressure calibration method shown in fig. 9, which includes:
step 901, a measurement subject initiates a calibration process;
step 902, the measurement subject collects and measures the pulse wave signal;
step 903, whether the wearing detection and activity intensity conditions are met. The measurement main body confirms whether wearing detection and activity intensity conditions are met or not, and if the wearing detection and activity intensity conditions are not met, the user is prompted to correctly measure or keep stable;
step 904, whether a valid time window condition is satisfied. Confirming whether the effective time window condition is met or not, and if not, starting a calibration unit to calibrate blood pressure measurement; the effective window condition is that the difference between the acquisition time of the pulse wave signal and the time between the last blood pressure measurement stored by the calibration unit does not exceed the length of a preset time window; if less than the preset time window length, one possible way is to directly use the last occurring blood pressure measurement value stored by the calibration unit;
step 905, starting calibration blood pressure measurement;
step 906, the measurement subject initiates a calibration process to collect a second calibration signal;
step 907, determining whether the second calibration signal contains a real pulse wave. If not, prompting the user to adopt a correct measurement mode;
step 908, prompt the user to take the correct measurement mode.
Step 909, collecting a first calibration signal and a second calibration signal;
step 910, deleting invalid pulse waves in the first calibration signal and the second calibration signal;
and step 911, reconstructing invalid pulse waves. There are two options here, if the user is wearing with a contralateral arm, only the invalid pulse waves of the first calibration signal need to be reconstructed; reconstructing the invalid pulse waves of the first calibration signal and the second calibration signal if the user is wearing the same side of the arm;
step 912, obtaining a first signal quality and a second signal quality;
step 913, a first systolic pressure and a first diastolic pressure are obtained. If the user wears the arm on the opposite side, outputting the first systolic pressure and the first diastolic pressure as a systolic pressure calibration value and a diastolic pressure calibration value;
at step 914, a second systolic pressure and a second diastolic pressure are obtained. If the user wears the ipsilateral arm, outputting the weighted average of the first systolic pressure and the second systolic pressure as a systolic pressure calibration value, and outputting the weighted average of the first diastolic pressure and the second diastolic pressure as a diastolic pressure calibration value;
and 915, judging whether the first signal quality and the second signal quality both meet preset quality conditions.
Step 916, the user is prompted to fail to calibrate the blood pressure measurement. If the first signal quality and the second signal quality do not meet the preset quality condition, prompting the user that the blood pressure measurement calibration fails;
step 917, obtaining a blood pressure calibration value;
step 918, prompting the user to measure correctly or keep stable;
step 919, extracting physiological parameters. Confirming that the valid time window is met, and extracting pulse wave related physiological parameters from the measured pulse wave signals;
step 920, updating the physiological parameter-blood pressure model;
step 921, the measurement subject performs blood pressure measurement. The measuring subject can carry out blood pressure measurement according to a physiological parameter-blood pressure model.
Example four:
corresponding to the above method embodiment, an embodiment of the present invention provides a blood pressure calibration device, which is applied to a blood pressure measurement system, and referring to a schematic structural diagram of a blood pressure calibration device shown in fig. 10, the blood pressure calibration device includes:
a first part pressure applying module 1001 for applying pressure to a first part of a user through a first acquisition submodule;
a calibration signal acquiring module 1002, configured to acquire a first calibration signal generated by a first part of a user and a second calibration signal generated by a second part of the user; the calibration signal is a pulse wave sequence generated by a user in the pressurizing process;
a blood pressure calibration value calculation module 1003, configured to calculate a blood pressure calibration value of the user based on the first calibration signal and the second calibration signal in a fusion manner.
The blood pressure calibration device provided by the embodiment of the invention is used for calculating the blood pressure calibration value of a user based on a first calibration signal generated by a first part and a second calibration signal generated by a second part in a fusion manner; and updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter of the user. In the method, a plurality of signal sources such as the first calibration signal and the first calibration signal are adopted for calibration, so that the reliability and the precision of blood pressure calibration can be improved.
The first part and the second part are positioned on the same side arm or different side arms; if the first part and the second part are positioned on the arm at the same side, the first part is arranged at the position of the artery at the heart end of the arm at the same side, and the second part is arranged at the position of the artery at the heart end of the arm at the same side; if the first part and the second part are positioned on the arms on different sides, the first part and the second part are respectively arranged at the artery blood vessels of the arms on different sides.
The blood pressure calibration value calculation module is used for performing bidirectional fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user if the first part and the second part are positioned on the arm on the same side; and if the first part and the second part are positioned on the arms on different sides, performing one-way fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user.
The blood pressure calibration value calculation module is used for determining the characteristics of the first calibration signal and the second calibration signal; wherein the features at least include: calibrating the main wave crest time of each pulse wave in the signal; deleting invalid pulse waves in the first calibration signal based on the characteristics of the first calibration signal; deleting invalid pulse waves in the second calibration signal based on the characteristics of the second calibration signal; and if the first main wave crest moment of the first calibration signal lacks the second main wave crest moment, reconstructing the missing characteristic corresponding to the second main wave crest moment based on the characteristics of a plurality of second calibration signals before and after the first main wave crest moment.
The blood pressure calibration value calculation module is used for determining the characteristics of the first calibration signal and the second calibration signal; is characterized by comprising the following steps: calibrating the main wave crest time, the main wave amplitude, the main wave starting time and the main wave ending time of each pulse wave in the signal; compensating the first calibration signal based on characteristics of the second calibration signal; compensating the second calibration signal based on the characteristic of the first calibration signal; a first signal quality of the first calibration signal and a second signal quality of the second calibration signal are calculated based on the compensated characteristics of the first calibration signal and the compensated characteristics of the second calibration signal.
The blood pressure calibration value calculation module is configured to reconstruct a missing feature corresponding to a second dominant wave peak time based on features of a plurality of second calibration signals before and after the first dominant wave peak time if the first dominant wave peak time of the first calibration signal lacks the second dominant wave peak time; the blood pressure calibration value calculation module is configured to reconstruct a missing feature corresponding to a first dominant wave peak time based on features of a plurality of first calibration signals before and after the second dominant wave peak time if the second dominant wave peak time of the second calibration signal lacks the first dominant wave peak time.
The blood pressure calibration value calculation module is further used for determining the average pressure measurement value MAP and the first systolic pressure measurement value SBP of the user by adopting a variable amplitude coefficient method based on the characteristics of the first calibration signal 1 And a first diastolic measurement DBP 1 (ii) a If the calculation is a two-way fusion, a second systolic measurement SBP is calculated based on the characteristics of the second calibration signal 2 (ii) a Inputting the characteristic of the second calibration signal and the mean pressure measurement MAP into a preset second diastolic model to obtain a second diastolic measurement DBP 2 。
The blood pressure calibration value calculation module is used for taking the pressure corresponding to the arterial vessel blockage time in the inflatable measurement or the arterial vessel opening time in the deflating measurement as the second systolic pressure measurement value SBP 2 (ii) a Wherein the artery vessel occlusion time is the main wave amplitude of the second calibration signalThe time changes from large to small and to stable starting time; the opening time of the artery blood vessel is the stable ending time when the main wave amplitude of the second calibration signal is changed from stable to small to large along with the time.
The blood pressure calibration value calculation module is also used for calculating the first systolic blood pressure measurement value SBP if the blood pressure calibration value is a one-way fusion calculation 1 As a calibration systolic pressure, a first diastolic pressure measurement DBP is taken 1 As a calibrated diastolic pressure; if the calculation is bidirectional fusion calculation, the first signal quality and the second signal quality are used as weights, and the first systolic pressure measurement value SBP is used 1 And a second systolic blood pressure measurement SBP 2 As a calibrated systolic pressure, the first diastolic pressure measurement DBP 1 And a second diastolic pressure measurement DBP 2 The weighted average of (a) is used as the calibrated diastolic pressure.
The blood pressure calibration value comprises a calibrated diastolic pressure and a calibrated systolic pressure, and the device further comprises: the physiological parameter blood pressure model updating module is used for acquiring a corrected signal of a user; the corrected signal is a pulse wave sequence generated by the user; acquiring physiological parameters of the user based on the corrected signals, and updating a physiological parameter blood pressure model of the user based on the calibrated diastolic pressure, the calibrated systolic pressure and the physiological parameters, wherein the physiological parameter blood pressure model is used for calculating the current blood pressure value of the user according to the physiological parameters; the physiological parameter includes at least one of: the height, age, sex, body mass index BMI, arm circumference and wrist circumference information of the user, and the corrected signal at least comprises one of the following information: pulse wave velocity information, pulsatile blood volume change information, or heart rate information.
The physiological parameter blood pressure model updating module is used for updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter if the wearing detection condition and the effective calibration time window condition are both satisfied; the wearing detection condition represents that the direct current component of the corrected signal reaches a preset amplitude value, and the frequency spectrum distribution of the alternating current component is matched with the preset distribution; the effective calibration time window condition represents that the acquisition time of the calibrated signal and the generation time of the blood pressure calibration value accord with a preset time length relation.
The physiological parameter blood pressure model updating module is also used for comparing at least one parameter of pulse wave conduction velocity information, pulse blood volume change information or heart rate information with the same type of parameters of the physiological parameter blood pressure model of the user to obtain a comparison result; and if the comparison result exceeds a preset reference proportion, updating the physiological parameter blood pressure model of the user.
It can be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working process of the blood pressure calibration device described above may refer to the corresponding process in the embodiment of the blood pressure calibration method, and is not described herein again.
Example four:
the embodiment of the invention also provides electronic equipment for operating the blood pressure calibration method; referring to fig. 11, an electronic device is shown, which includes a memory 100 and a processor 101, wherein the memory 100 is used for storing one or more computer instructions, and the one or more computer instructions are executed by the processor 101 to implement the blood pressure calibration method.
Further, the electronic device shown in fig. 11 further includes a bus 102 and a communication interface 103, and the processor 101, the communication interface 103, and the memory 100 are connected through the bus 102.
The Memory 100 may include a high-speed Random Access Memory (RAM) and may further include a non-volatile Memory (non-volatile Memory), such as at least one disk Memory. The communication connection between the network element of the system and at least one other network element is realized through at least one communication interface 103 (which may be wired or wireless), and the internet, a wide area network, a local network, a metropolitan area network, and the like can be used. The bus 102 may be an ISA bus, PCI bus, EISA bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc. For ease of illustration, only one double-headed arrow is shown in FIG. 11, but that does not indicate only one bus or one type of bus.
The processor 101 may be an integrated circuit chip having signal processing capabilities. In implementation, the steps of the above method may be performed by integrated logic circuits of hardware or instructions in the form of software in the processor 101. The Processor 101 may be a general-purpose Processor, and includes a Central Processing Unit (CPU), a Network Processor (NP), and the like; the device can also be a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA) or other Programmable logic device, a discrete Gate or transistor logic device, or a discrete hardware component. The various methods, steps and logic blocks disclosed in the embodiments of the present invention may be implemented or performed. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like. The steps of the method disclosed in connection with the embodiments of the present invention may be directly implemented by a hardware decoding processor, or implemented by a combination of hardware and software modules in the decoding processor. The software module may be located in ram, flash memory, rom, prom, or eprom, registers, etc. storage media as is well known in the art. The storage medium is located in the memory 100, and the processor 101 reads the information in the memory 100, and completes the steps of the method of the foregoing embodiment in combination with the hardware thereof.
An embodiment of the present invention further provides a computer-readable storage medium, where the computer-readable storage medium stores computer-executable instructions, and when the computer-executable instructions are called and executed by a processor, the computer-executable instructions cause the processor to implement the blood pressure calibration method.
The blood pressure calibration method, the blood pressure calibration device, the blood pressure measurement system, and the computer program product of the electronic device provided in the embodiments of the present invention include a computer-readable storage medium storing program codes, instructions included in the program codes may be used to execute the method in the foregoing method embodiments, and specific implementations may refer to the method embodiments and are not described herein again.
It can be clearly understood by those skilled in the art that, for convenience and simplicity of description, the specific working process of the system and/or the apparatus described above may refer to the corresponding process in the foregoing method embodiment, and details are not described herein again.
In addition, in the description of the embodiments of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The functions, if implemented in the form of software functional units and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention may be embodied in the form of a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk, or an optical disk, and various media capable of storing program codes.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (18)

1. A blood pressure calibration method is applied to a blood pressure measurement system, and comprises the following steps:
applying pressure to a first part of a user through a first acquisition submodule;
acquiring a first calibration signal generated by a first part of the user and a second calibration signal generated by a second part of the user; wherein the calibration signal is a pulse wave sequence generated by the user during the pressing process; the first acquisition submodule is used for acquiring the first calibration signal, and the second acquisition submodule is used for acquiring the second calibration signal; the first acquisition submodule comprises an electronic sphygmomanometer based on inflatable measurement or deflatable measurement; the second acquisition submodule includes at least one of: a photoelectric volume plotter, a laser radar, an optical imaging and a piezoelectric capacitance sensor;
and fusion-calculating the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
2. The method of claim 1, wherein the first site and the second site are in the ipsilateral arm or the contralateral arm;
if the first part and the second part are positioned on the arm on the same side, the first part is arranged at the position of the artery at the proximal end of the arm on the same side, and the second part is arranged at the position of the artery at the distal end of the arm on the same side;
if the first part and the second part are positioned on the arms on different sides, the first part and the second part are respectively arranged at the artery blood vessels of the arms on different sides.
3. The method of claim 2, wherein the step of fusion computing the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal comprises:
if the first part and the second part are positioned on the same side of the arm, performing bidirectional fusion calculation on the first calibration signal and the second calibration signal to determine the blood pressure calibration value of the user;
and if the first part and the second part are positioned on the arms on different sides, performing unidirectional fusion calculation on the first calibration signal and the second calibration signal, and determining the blood pressure calibration value of the user.
4. The method of claim 3, wherein the step of performing a one-way fusion computation on the first calibration signal and the second calibration signal comprises:
determining a characteristic of the first calibration signal and a characteristic of the second calibration signal; wherein the features include at least: calibrating the time of the main wave crest of each pulse wave in the signal;
deleting invalid pulse waves in the first calibration signal based on the characteristics of the first calibration signal;
deleting invalid pulse waves in the second calibration signal based on the characteristics of the second calibration signal;
and if the first main wave crest moment of the first calibration signal lacks a second main wave crest moment, reconstructing a missing feature corresponding to the second main wave crest moment based on the features of a plurality of second calibration signals before and after the first main wave crest moment.
5. The method of claim 4, wherein the step of performing bi-directional fusion computation on the first calibration signal and the second calibration signal comprises:
determining a characteristic of the first calibration signal and a characteristic of the second calibration signal; the features include: calibrating the time of a main wave crest, the amplitude of the main wave, the start time of the main wave and the end time of the main wave of each pulse wave in the signal;
compensating the first calibration signal based on characteristics of the second calibration signal;
compensating the second calibration signal based on characteristics of the first calibration signal;
calculating a first signal quality of the first calibration signal and a second signal quality of the second calibration signal based on the compensated characteristics of the first calibration signal and the compensated characteristics of the second calibration signal.
6. The method of claim 5, wherein the step of compensating the second calibration signal based on the characteristics of the first calibration signal comprises:
if a first main wave crest moment of the first calibration signal lacks a second main wave crest moment, reconstructing a missing feature corresponding to the second main wave crest moment based on features of a plurality of second calibration signals before and after the first main wave crest moment;
the step of compensating the first calibration signal based on the characteristics of the second calibration signal comprises:
and if the second main wave crest moment of the second calibration signal lacks the first main wave crest moment, reconstructing the missing characteristic corresponding to the first main wave crest moment based on the characteristics of a plurality of first calibration signals before and after the second main wave crest moment.
7. The method of claim 5, further comprising:
determining the average pressure measurement MAP and the first systolic pressure measurement SBP of the user by adopting a variable amplitude coefficient method based on the characteristics of the first calibration signal 1 And a first diastolic measurement DBP 1 ；
If the calculation is a two-way fusion calculation, a second systolic blood pressure measurement SBP is calculated based on the characteristics of the second calibration signal 2 (ii) a Inputting the characteristics of the second calibration signal and the average pressure measurement MAP into a preset second diastolic pressure model to obtain a second diastolic pressure measurement DBP 2 。
8. Method according to claim 7, characterized in that a second systolic blood pressure measurement SBP is calculated on the basis of characteristics of the second calibration signal 2 The method comprises the following steps:
the pressure corresponding to the arterial vessel blockage time in the inflation type measurement or the arterial vessel opening time in the deflation type measurement is taken as a second systolic pressure measurement value SBP 2 (ii) a Wherein the arterial vessel occlusion time is a stable starting time when the dominant wave amplitude of the second calibration signal changes from large to small and becomes stable along with the time; the arterial vessel opening time is a stable ending time when the dominant wave amplitude of the second calibration signal is changed from stable to small to large along with the time.
9. The method of claim 7, wherein the blood pressure calibration values comprise a calibrated systolic pressure and a calibrated diastolic pressure; the step of determining the blood pressure calibration value of the user further comprises:
if the calculation is one-way fusion, the first systolic blood pressure measurement value SBP is calculated 1 As the calibrated systolic pressure, the first diastolic pressure measurement DBP is used 1 As the calibrated diastolic pressure;
if the calculation is bidirectional fusion calculation, the first systolic blood pressure measurement value SBP is used as a weight by using the first signal quality and the second signal quality 1 And the second systolic measurementSBP 2 As the calibrated systolic pressure, the first diastolic pressure measurement DBP 1 And said second diastolic blood pressure measurement DBP 2 As the calibrated diastolic pressure.
10. The method of claim 1, wherein the blood pressure calibration value comprises a calibrated diastolic blood pressure and a calibrated systolic blood pressure, and wherein the method further comprises, after the step of fusion computing the blood pressure calibration value for the user based on the first calibration signal and the second calibration signal:
acquiring a corrected signal of the user; the corrected signal is a pulse wave sequence generated by the user;
acquiring a physiological parameter of the user based on the corrected signal, and updating a physiological parameter blood pressure model of the user based on the calibrated diastolic pressure, the calibrated systolic pressure and the physiological parameter, wherein the physiological parameter blood pressure model is used for calculating a current blood pressure value of the user according to the physiological parameter;
the physiological parameter includes at least one of: the height, age, sex, body mass index BMI, arm circumference and wrist circumference information of the user, and the corrected signal at least comprises one of the following information: pulse wave velocity information, pulsatile blood volume change information, or heart rate information.
11. The method of claim 10, wherein the step of updating the physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter comprises:
if the wearing detection condition and the effective calibration time window condition are both satisfied, updating a physiological parameter blood pressure model of the user based on the blood pressure calibration value and the physiological parameter;
the wearing detection condition represents that the direct current component of the corrected signal reaches a preset amplitude value, and the frequency spectrum distribution of the alternating current component is matched with a preset distribution; and the effective calibration time window condition represents that the acquisition time of the calibrated signal and the occurrence time of the blood pressure calibration value accord with a preset time length relation.
12. The method of claim 10, wherein the step of updating the physiological parameter blood pressure model of the user based on the calibrated diastolic pressure, the calibrated systolic pressure, and the physiological parameter further comprises:
comparing at least one parameter of pulse wave velocity information, pulse blood volume change information or heart rate information with the same type of parameters of the physiological parameter blood pressure model of the user to obtain a comparison result;
and if the comparison result exceeds a preset reference proportion, updating the physiological parameter blood pressure model of the user.
13. A blood pressure calibration device, which is applied to a blood pressure measurement system, the device comprising:
the first part pressure applying module is used for applying pressure to a first part of a user through the first acquisition submodule;
a calibration signal acquisition module for acquiring a first calibration signal generated by a first part of the user and a second calibration signal generated by a second part of the user; wherein the calibration signal is a pulse wave sequence generated by the user during the pressing process; the first acquisition submodule is used for acquiring the first calibration signal, and the second acquisition submodule is used for acquiring the second calibration signal; the first acquisition submodule comprises an electronic sphygmomanometer based on inflatable measurement or deflatable measurement; the second acquisition submodule includes at least one of: a photoelectric volume plotter, a laser radar, an optical imaging and a piezoelectric capacitance sensor;
and the blood pressure calibration value calculation module is used for fusion calculation of the blood pressure calibration value of the user based on the first calibration signal and the second calibration signal.
14. A blood pressure measurement system, comprising: a calibration unit and a measurement body;
the calibration unit is used for calculating a blood pressure calibration value based on multi-channel pulse wave signal fusion and sending the blood pressure calibration value to the measurement main body;
the measurement main body is used for updating a physiological parameter blood pressure model of the user according to the blood pressure calibration value and calculating the current blood pressure value of the user according to the updated physiological parameter blood pressure model and the current physiological parameter of the user;
the calibration unit includes: the calibration pulse wave acquisition module, the calibration processor, the calibration communication module and the calibration storage module;
the calibration pulse wave acquisition module comprises a first acquisition submodule and a second acquisition submodule; the first acquisition sub-module comprises an electronic sphygmomanometer based on inflatable measurement or deflatable measurement and is used for acquiring a first calibration signal;
the second acquisition submodule includes at least one of: the second acquisition submodule is used for acquiring a second calibration signal;
the second acquisition sub-module is separated from the calibration unit in a wireless or wired mode and at least comprises an accelerometer or a gyroscope, and the second acquisition sub-module is also used for judging whether the user is in a stable state or not when acquiring the first calibration signal and the second calibration signal;
the calibration processor is used for fusing the first calibration signal and the second calibration signal and calculating a blood pressure calibration value;
the calibration communication module is connected with the calibration processor and is used for sending a blood pressure calibration value, the occurrence time of the blood pressure calibration value and a calibration instruction to the measurement subject;
the calibration storage module is connected with the calibration processor and is used for storing the blood pressure calibration value and the occurrence time of the blood pressure calibration value.
15. The system of claim 14, wherein the measurement body comprises: the device comprises a main body pulse wave acquisition module, a main body processor, a main body storage module and a main body communication module;
the main body pulse wave acquisition module at least comprises one of the following modules: the device comprises a photoelectric plethysmograph, a laser radar, an optical imaging, a piezoelectric capacitor and an electrocardio sensor, wherein the main body pulse wave acquisition module is used for acquiring a corrected signal; the main body pulse wave acquisition module at least comprises an accelerometer or a gyroscope and is used for judging whether the user is in a stable state or not when acquiring the pulse wave signals;
the main body communication module is used for receiving the blood pressure calibration value and sending a calibration instruction to the calibration unit;
the main body storage module is used for storing the physiological parameter blood pressure model and storing the blood pressure calibration value, the occurrence time of the blood pressure calibration value and the physiological parameter;
the main body processor is used for updating the physiological parameter blood pressure model according to the blood pressure calibration value; and calculating the current blood pressure value of the user according to the updated physiological parameter blood pressure model and the current physiological parameter of the user.
16. The system of claim 14, wherein the measurement body includes the second acquisition submodule, if the second acquisition submodule is separate from the calibration unit, for providing the second calibration signal.
17. An electronic device comprising a processor and a memory, the memory storing computer-executable instructions executable by the processor, the processor executing the computer-executable instructions to implement the blood pressure calibration method of any one of claims 1 to 12.
18. A computer-readable storage medium having stored thereon computer-executable instructions which, when invoked and executed by a processor, cause the processor to carry out the blood pressure calibration method of any one of claims 1 to 12.
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