CN113749093B - Low-temperature synergistic compound amine disinfectant and preparation method thereof - Google Patents
Low-temperature synergistic compound amine disinfectant and preparation method thereof Download PDFInfo
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 47
- -1 compound amine Chemical class 0.000 title claims abstract description 31
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- XMMDVXFQGOEOKH-UHFFFAOYSA-N n'-dodecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCNCCCN XMMDVXFQGOEOKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims abstract description 9
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 38
- 238000002156 mixing Methods 0.000 claims description 27
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 21
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 8
- 239000012964 benzotriazole Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 20
- 230000001954 sterilising effect Effects 0.000 abstract description 16
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 229960000686 benzalkonium chloride Drugs 0.000 abstract description 6
- 230000007797 corrosion Effects 0.000 abstract description 6
- 238000005260 corrosion Methods 0.000 abstract description 6
- 238000003860 storage Methods 0.000 abstract description 6
- 239000006184 cosolvent Substances 0.000 abstract description 5
- 239000002736 nonionic surfactant Substances 0.000 abstract description 5
- 229960002233 benzalkonium bromide Drugs 0.000 abstract description 4
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical group [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 abstract description 4
- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 abstract description 4
- UMGXUWVIJIQANV-UHFFFAOYSA-M didecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC UMGXUWVIJIQANV-UHFFFAOYSA-M 0.000 abstract description 4
- 230000009471 action Effects 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract description 2
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 6
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical class OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 6
- 239000004115 Sodium Silicate Substances 0.000 description 5
- 241000700605 Viruses Species 0.000 description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 5
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 5
- 229910052911 sodium silicate Inorganic materials 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000005708 Sodium hypochlorite Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229960005102 foscarnet Drugs 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- ZQBVUULQVWCGDQ-UHFFFAOYSA-N propan-1-ol;propan-2-ol Chemical compound CCCO.CC(C)O ZQBVUULQVWCGDQ-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-temperature synergistic compound amine disinfectant and a preparation method thereof, belonging to the technical field of disinfectant preparation and comprising the following raw materials in parts by weight: 1 to 10 percent of quaternary ammonium salt, 0.2 to 2 percent of N-dodecyl-1, 3-propane diamine, 1 to 5 percent of cosolvent, 1 to 5 percent of nonionic surfactant and the balance of water to 100 percent; the quaternary ammonium salt is selected from benzalkonium bromide, benzalkonium chloride, octyl decyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride, and didecyl dimethyl ammonium bromide. The low-temperature synergistic compound amine disinfectant and the preparation method thereof provided by the invention enable the quaternary ammonium salt to fully exert the sterilization performance under the appropriate dissolution concentration, viscosity and pH value, improve the sterilization effect of the disinfectant in a low-temperature environment, have lower use concentration, obvious sterilization effect within limited action time, have small corrosion on the surface of an object, and are particularly suitable for the sterilization of a cold storage, cold chain transportation equipment and other low-temperature environments.
Description
Technical Field
The invention relates to a low-temperature synergistic compound amine disinfectant and a preparation method thereof, belonging to the technical field of disinfectant preparation.
Background
Since the emergence of new crown epidemic, low-temperature and cold chain disinfection become more prominent points in epidemic prevention and control work, because many viruses including new crown viruses have the characteristics of cold resistance and heat resistance, the viruses do not have cell structures, and ice crystals generated during low-temperature and freezing can not kill the viruses but prolong the survival time of the viruses on articles. The cold chain food and the transportation equipment in a low temperature state have the risk of being polluted by the new coronavirus in the production, loading, unloading, transportation, storage, sale and other links, and the new coronavirus nucleic acid is mostly detected from the external package samples of the imported cold chain food. Although the current mainstream disinfectant has ideal sterilizing effect in a normal temperature environment of 18-35 ℃, the sterilizing effect in a low temperature environment is unstable. Secondly, the surfaces of large-area objects such as wall surfaces, ground surfaces and the like are generally cleaned and disinfected by sodium hypochlorite, peracetic acid and the like, and the two disinfectants have the biggest problem of residue and simultaneously have pungent smell; and peracetic acid can corrode large surfaces after long-term use, and sodium hypochlorite can damage respiratory tracts.
The quaternary ammonium salt is a product obtained by replacing a plurality of hydrogen atoms in ammonia molecules with alkyl groups, the sterilization mechanism of the quaternary ammonium salt is mainly that a substance with positive charges is formed in water, and is adsorbed on the surface of a microorganism with negative charges and enters the microorganism to destroy the integrity of the microorganism, so that the microorganism is killed. However, the single quaternary ammonium salt bactericide has limited bactericidal effect under certain use environments, and can generate drug resistance after being used alone for a long time, and the quaternary ammonium salt has more incompatibility and large influence on the bactericidal effect by the environment.
The above description is included in the technical recognition scope of the inventors, and does not necessarily constitute the prior art.
Disclosure of Invention
The invention aims to solve the problems in the prior art, provides a low-temperature synergistic compound amine disinfectant and a preparation method thereof, has low use concentration, short action time and obvious disinfection effect, and is particularly suitable for disinfection in low-temperature environments such as a refrigeration house, cold chain transportation equipment and the like.
The invention adopts the following technical scheme to realize the purpose:
on one hand, the invention provides a low-temperature synergistic compound amine disinfectant, which comprises the following raw materials in parts by weight: 1 to 10 percent of quaternary ammonium salt, 0.2 to 2 percent of N-dodecyl-1, 3-propane diamine, 1 to 5 percent of cosolvent, 1 to 5 percent of nonionic surfactant and the balance of water to 100 percent;
the quaternary ammonium salt is selected from one or more of benzalkonium bromide, benzalkonium chloride, octyl decyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium bromide;
the pH value of the low-temperature synergistic compound amine disinfectant is 9-11, and the viscosity is 15-25mpa.s.
Optionally, the low-temperature synergistic compound amine disinfectant also comprises 0.1-1% of a corrosion inhibitor.
Optionally, the corrosion inhibitor is selected from one or more of sodium silicate, tungstate, benzotriazole and phosphonic carboxylic acid.
Optionally, the cosolvent is selected from one or more of ethanol, ethylene glycol and isopropanol.
Optionally, the nonionic surfactant is selected from one or more of isomeric tridecanol polyoxyethylene ethers with specifications of E-1303, E-1304, E-1306, E-1308, E-1310 and E-1320.
Preferably, the low-temperature synergistic compound amine disinfectant provided by the invention is prepared from the following raw materials in parts by weight: 3 to 8 percent of didecyl dimethyl ammonium chloride, 0.5 to 1.5 percent of N-dodecyl-1, 3-propane diamine, 2 to 4 percent of isopropanol, 2 to 4 percent of isomeric tridecanol polyoxyethylene ether with the specification of E-1320 and 0.2 to 0.8 percent of benzotriazole.
On the other hand, the invention also provides a preparation method of the low-temperature synergistic compound amine disinfectant, which comprises the following steps:
(1) Uniformly stirring and mixing the cosolvent and the nonionic surfactant, and standing for 8-12min at normal temperature and normal pressure;
(2) Sequentially adding quaternary ammonium salt, stirring uniformly, adding N-dodecyl-1, 3-propane diamine, stirring uniformly, adding the corrosion inhibitor, stirring uniformly;
(3) Adding water, stirring and mixing evenly, and filtering to obtain the low-temperature synergistic compound amine disinfectant.
The beneficial effects of the invention include but are not limited to:
the low-temperature synergistic compound amine disinfectant and the preparation method thereof provided by the invention have the advantages that the quaternary ammonium salt, the N-dodecyl-1, 3-propane diamine, the cosolvent, the nonionic surfactant and the like are reasonably compounded, so that the quaternary ammonium salt can fully exert the sterilization performance under proper dissolution concentration, viscosity and pH, the sterilization effect of the disinfectant in a low-temperature environment is improved, the use concentration of the disinfectant is lower, the sterilization effect is obvious within a limited action time, and the corrosion to the surface of an object is small. The disinfectant can be used at normal temperature and low temperature, and is especially suitable for cleaning and disinfecting large surfaces (walls, floors and ceilings) in low-temperature environments such as ports and docks, cold storages, cold chain logistics vehicles, supermarket storage and the like.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:
FIG. 1 is a side view of the disinfectant prepared in comparative example 2 and example 4 in a beaker;
FIG. 2 is a top view of the disinfectant prepared in comparative example 2 and example 4 in a beaker;
Detailed Description
The present invention will be described in further detail in the following. It should be noted, however, that the following detailed description merely gives specific operation examples of the present invention by way of example, and the scope of the present invention is not limited thereto. The scope of the invention is limited only by the claims. It will be obvious to those skilled in the art that various other modifications and substitutions can be made to the described embodiments of the invention within the scope of the invention as defined by the claims and still achieve the same technical result and achieve the final technical object of the invention.
In the present invention, all percentages are by weight and the temperature is given in degrees Celsius. All numerical ranges recited herein are inclusive of the endpoints and include new numerical ranges that combine any of the upper and lower limits of the disclosed ranges with one another.
Unless otherwise specified, each raw material is commercially available in this specification.
Example 1:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 1
| Starting materials | Content (%) |
| Didecyl dimethyl ammonium chloride | 1 |
| N-dodecyl-1, 3-propanediamine | 2 |
| Isopropanol (I-propanol) | 5 |
| E-1320 | 5 |
| Benzotriazole | 0.1 |
| Water (W) | 86.9 |
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: firstly, uniformly stirring and mixing isopropanol and E-1320, and standing for 10 minutes at normal temperature and normal pressure; then adding didecyl dimethyl ammonium chloride in sequence, stirring and mixing uniformly, adding N-dodecyl-1, 3-propane diamine, stirring and mixing uniformly, adding benzotriazole, stirring and mixing uniformly, finally adding water, filtering and packaging. The preparation method enables the quaternary ammonium salt to be fully dissolved and mixed with other components to form a stable solution by strictly controlling the adding sequence of each component.
Example 2:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 2
| Raw materials | Content (%) |
| Benzalkonium chloride | 3 |
| N-dodecyl-1, 3-propanediamine | 1.6 |
| Ethanol | 4 |
| E-1304 | 4 |
| Phosphonocarboxylic acids | 0.4 |
| Water (W) | 87 |
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: stirring ethanol and E-1304 uniformly, standing for 12 minutes at normal temperature and normal pressure, sequentially adding benzalkonium chloride, stirring uniformly, adding N-dodecyl-1, 3-propanediamine, stirring uniformly, adding phosphonocarboxylic acid, stirring uniformly, finally adding water, filtering, and subpackaging.
Example 3:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 3
| Starting materials | Content (%) |
| Benzalkonium bromide | 5 |
| N-dodecyl-1, 3-propanediamine | 1.2 |
| Ethylene glycol | 2.8 |
| E-1306 | 3 |
| Benzotriazole | 0.4 |
| Phosphonocarboxylic acids | 0.2 |
| Water (W) | 87.4 |
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: stirring and mixing ethylene glycol and E-1306 uniformly, standing for 10 minutes at normal temperature and normal pressure to enable ethylene glycol and E-1306 to be fully mutually soluble, then sequentially adding benzalkonium bromide, stirring and mixing uniformly, adding N-dodecyl-1, 3-propane diamine, stirring and mixing uniformly, adding benzotriazole and phosphono carboxylic acid, stirring and mixing uniformly, finally adding water, filtering and subpackaging.
Example 4:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 4
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: uniformly stirring and mixing the isopropanol and the E-1304, and standing for 8 minutes at normal temperature and normal pressure; then adding didecyl dimethyl ammonium chloride in sequence, stirring and mixing uniformly, adding N-dodecyl-1, 3-propane diamine, stirring and mixing uniformly, adding sodium silicate, stirring and mixing uniformly, finally adding water, filtering and packaging.
Example 5:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 5
| Starting materials | Content (%) |
| Octyl decyl dimethyl ammonium chloride | 10 |
| N-dodecyl-1, 3-propanediamine | 0.2 |
| Isopropanol (I-propanol) | 1 |
| E-1308 | 1 |
| Tungstate salt | 0.8 |
| Water (I) | 87 |
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: uniformly stirring and mixing the isopropanol and the E-1308, and standing for 10 minutes at normal temperature and normal pressure; and sequentially adding octyl decyl dimethyl ammonium chloride, stirring, adding N-dodecyl-1, 3-propane diamine, stirring, adding tungstate, stirring, adding water, filtering, and packaging.
Example 6:
the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following components in percentage by weight:
TABLE 6
| Raw materials | Content (%) |
| Didecyl dimethyl ammonium Bromide | 8 |
| N-dodecyl-1, 3-propanediamine | 1.5 |
| Isopropyl alcohol | 3 |
| E-1306 | 1.2 |
| Sodium silicate | 0.2 |
| Water (I) | 86.1 |
The preparation method of the low-temperature synergistic compound amine disinfectant provided by the embodiment comprises the following steps: stirring and uniformly mixing the isopropanol and the E-1306, and standing for 12 minutes at normal temperature and normal pressure; then adding didecyl dimethyl ammonium bromide in sequence, stirring and mixing uniformly, adding N-dodecyl-1, 3-propane diamine, stirring and mixing uniformly, adding sodium silicate, stirring and mixing uniformly, finally adding water, filtering and packaging.
The use method of the low-temperature synergistic compound amine disinfectant provided by the embodiments 1 to 6 of the invention comprises the following steps: diluting appropriate amount of stock solution to 80-200 times at low temperature or normal temperature, and smearing or wiping hard object surface for 1-2 times within 3-60min for disinfection.
Wherein the low temperature environment is 0-4 ℃. The hard object surface comprises the surfaces of walls, floors and ceilings of laboratories, clean plants, cold storages and the like, and the surfaces of refrigerated transport vehicles, supermarket storage refrigerated cabinets, port wharfs and the like.
Comparative example 1:
comparative example 1 differs from example 2 in that: the N-dodecyl-1, 3-propane diamine is replaced by N, N-bis-hydroxyethyl alkyl amide, so that the sterilization effect is reduced (the reduction at 0 ℃ is obvious).
Comparative example 2:
comparative example 2 differs from example 4 in that: the preparation method of the disinfectant comprises the following steps: stirring and uniformly mixing didecyl dimethyl ammonium chloride and E-1304, standing for 12 minutes at normal temperature and normal pressure, adding water, stirring and uniformly mixing, adding N-dodecyl-1, 3-propane diamine, stirring and uniformly mixing, adding sodium silicate, stirring and uniformly mixing, and finally adding isopropanol. As shown in fig. 1 and 2, the disinfectant obtained in comparative example 2 is milky turbid, and the effective components in the disinfectant are not sufficiently fused, so that the required sterilization effect cannot be achieved.
And (3) sterilization test:
the following table shows laboratory sterilization tests performed when the disinfectant provided by the invention is diluted to have the quaternary ammonium salt content (calculated by benzalkonium chloride) of 0.05%, specifically, tests are performed by referring to a carrier method specified in disinfection technical specification (2002), and the sterilization effects of staphylococcus aureus (staphylococcus aureus) and Escherichia coli (Escherichia coli) after 3min and 10min are respectively verified in the environment of 25 ℃ and 0 ℃, and specific data are shown in the following table.
TABLE 7
As can be seen from the data in Table 7, the kill log values of the sterilization tests of the disinfectant carrier method provided by the invention are all more than 4.00.
The disinfectant provided by the embodiments 1-6 is diluted to 0.05% of quaternary ammonium salt content (calculated by benzalkonium chloride), and then is uniformly sprayed on a refrigerated transport vehicle carriage body at 0-4 ℃ for 2 times, wherein the spraying amount per square meter is 200-300 ml, the disinfection effect can be achieved by acting for more than 10min, the color and luster of the transport vehicle carriage body are not changed after 120min observation, and the problems of corrosion and residue in the use process of large-area object surface disinfectant such as sodium hypochlorite, peroxyacetic acid and the like are solved.
The above-described embodiments should not be construed as limiting the scope of the invention, and any alternative modifications or alterations to the embodiments of the present invention will be apparent to those skilled in the art.
The present invention is not described in detail, but is known to those skilled in the art.
Claims (2)
1. The low-temperature synergistic compound amine disinfectant is characterized by being prepared from the following raw materials in percentage by weight: 3 to 8 percent of didecyl dimethyl ammonium chloride, 0.5 to 1.5 percent of N-dodecyl-1, 3-propane diamine, 2 to 4 percent of isopropanol, 2 to 4 percent of isomeric tridecanol polyoxyethylene ether with the specification of E-1320, 0.2 to 0.8 percent of benzotriazole and the balance of water to 100 percent;
the pH value of the low-temperature synergistic compound amine disinfectant is 9-11, and the viscosity is 15-25mpa.s.
2. The preparation method of the low-temperature synergistic compound amine disinfectant as claimed in claim 1, which comprises the following steps:
(1) Uniformly stirring isopropanol and isomeric tridecanol polyoxyethylene ether with specification of E-1320, and standing for 8-12min at normal temperature and normal pressure;
(2) Adding didecyl dimethyl ammonium chloride in sequence, stirring and mixing uniformly, adding N-dodecyl-1, 3-propane diamine, stirring and mixing uniformly, adding benzotriazole, stirring and mixing uniformly;
(3) Adding water, stirring and mixing evenly, and filtering to obtain the low-temperature synergistic compound amine disinfectant.
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| IL190181A (en) * | 2008-03-16 | 2015-08-31 | Altos Medical Llc | Cleaning, sanitising and sterilising preparations |
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| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
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Address after: No. 1618 Dexing North Avenue, Tianqu Industrial Park, Tianqu Sub district Office, Decheng District, Dezhou City, Shandong Province, 253000 Patentee after: SHANDONG ANJIE HI-TECH DISINFECTION TECHNOLOGY Co.,Ltd. Address before: 253000 Dezhou Tianqu Industrial Park, Shandong Province 268 Dexing North Road Patentee before: SHANDONG ANJIE HI-TECH DISINFECTION TECHNOLOGY Co.,Ltd. |
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