CN113731333A - Chiral medicine mixing reaction device - Google Patents
Chiral medicine mixing reaction device Download PDFInfo
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- CN113731333A CN113731333A CN202111061509.3A CN202111061509A CN113731333A CN 113731333 A CN113731333 A CN 113731333A CN 202111061509 A CN202111061509 A CN 202111061509A CN 113731333 A CN113731333 A CN 113731333A
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 110
- 238000002156 mixing Methods 0.000 title claims abstract description 59
- 239000003814 drug Substances 0.000 title claims abstract description 50
- 239000007788 liquid Substances 0.000 claims abstract description 101
- 238000003756 stirring Methods 0.000 claims abstract description 82
- 239000000463 material Substances 0.000 claims abstract description 55
- 229940079593 drug Drugs 0.000 claims abstract description 39
- 230000007246 mechanism Effects 0.000 claims abstract description 36
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005086 pumping Methods 0.000 description 4
- 238000004891 communication Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000007599 discharging Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1862—Stationary reactors having moving elements inside placed in series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1868—Stationary reactors having moving elements inside resulting in a loop-type movement
- B01J19/1881—Stationary reactors having moving elements inside resulting in a loop-type movement externally, i.e. the mixture leaving the vessel and subsequently re-entering it
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention discloses a chiral drug mixing reaction device, which comprises a plurality of reaction kettles, wherein stirring and mixing mechanisms are respectively arranged in each reaction kettle, a material pipe sequentially penetrates through each reaction kettle and is fixedly connected with each stirring and mixing mechanism, the material pipe is communicated with each reaction kettle, is connected with the corresponding reaction kettle through a connecting mechanism and is connected with an output shaft of a variable-frequency driving motor, a connecting piece is arranged on the material pipe, a circulating pump is communicated with the material pipe through a liquid inlet pipe through the connecting piece, the circulating pump is communicated with the material pipe through a liquid outlet pipe, the liquid outlet pipe is communicated with a plurality of liquid return pipes, the liquid return pipes extend into the reaction kettles, and liquid return pipes, the liquid inlet pipe and the liquid outlet pipe are respectively provided with a liquid return control valve, a liquid inlet control valve and a liquid outlet control valve. The invention completes the mixing of a plurality of groups of medicine combinations in one step, and mixes the mixed medicines according to the requirements, thereby reducing the working procedures, lowering the investment, improving the production efficiency and lowering the investment of the production cost. The invention is suitable for the technical field of chiral drug production equipment.
Description
Technical Field
The invention belongs to the technical field of chiral drug production equipment, and particularly relates to a chiral drug mixing reaction device.
Background
In the production process of chiral drugs, it is necessary to stir a plurality of drugs (compounds) in a reaction vessel to form a mixed solution for the subsequent process. However, in order to mix these drugs uniformly, the method is generally adopted to increase the stirring time or reduce the amount of the drug mixed at one time, which greatly reduces the mixing efficiency and further affects the productivity of the chiral drug. Moreover, the production of some chiral drugs requires that a plurality of drugs are divided into more than two groups, the drugs of the groups are separately stirred in a reaction kettle, and are mixed after being stirred and fully reacted, and the mixed solution of the groups needs to be mixed pairwise or simultaneously in multiple groups according to specific chiral drugs, so that the required chiral drug mixed solution is finally formed, and further, the beneficial support is provided for the subsequent crystallization process. However, there is no better method for realizing the one-step independent mixing of multiple groups of medicines, and the medicines need to be stirred independently, then mixed, and then stirred, so that the process is complicated, the investment of equipment is large, the production efficiency is low, the investment of production cost is large, and the personnel allocation is large.
Disclosure of Invention
The invention provides a chiral drug mixing reaction device which is used for mixing a plurality of groups of drug combinations in one step and mixing the mixed drugs according to requirements so as to reduce production procedures, reduce equipment investment, improve production efficiency, reduce production cost investment and reduce personnel allocation.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a chiral drug mixing reaction device comprises a plurality of reaction kettles which are arranged in sequence along the vertical direction and are fixedly connected through a fixing frame, stirring and mixing mechanisms are respectively arranged in each reaction kettle, a material pipe sequentially penetrates through each reaction kettle from bottom to top along the axis of the reaction kettle and is fixedly connected with each stirring and mixing mechanism, the material pipe is respectively communicated with the bottom of each reaction kettle and is switched on and off with the corresponding reaction kettle through a switching mechanism arranged at the lower end of each reaction kettle, the lower end of the material pipe is coaxially connected with an output shaft of a variable frequency driving motor, a switching piece is rotatably arranged at the lower part of the material pipe, a circulating pump is communicated with the material pipe through a liquid inlet pipe, the circulating pump is communicated with the upper end of the material pipe through a liquid outlet pipe, a plurality of liquid return pipes are communicated with the liquid outlet pipe, and each liquid return pipe respectively extends into the corresponding reaction kettle and is positioned above the stirring and mixing mechanisms, and a liquid return control valve, a liquid inlet control valve and a liquid outlet control valve are respectively arranged on the liquid return pipe, the liquid inlet pipe and the liquid outlet pipe, and the liquid outlet control valve is positioned at the top of the liquid outlet pipe.
Furthermore, the stirring and mixing mechanism comprises a stirring cover fixedly installed on the material pipe, the stirring cover is overlapped with the axis of the material pipe, a plurality of upper swirling vanes are constructed on the inner wall of the stirring cover, and the upper swirling vanes are arranged at intervals along the circumferential direction of the stirring cover.
Furthermore, the radial length of the stirring cover is gradually enlarged upwards along the axial direction of the mounting rod, and each upper swirling vane extends from the lower end of the stirring cover to the upper end of the stirring cover.
Further, in install a plurality of drainage stirring leaves in the stirring cover, the drainage stirring leaf evenly sets up along the circumference of installation pole, and the one end of each drainage stirring leaf links firmly with corresponding upward vortex leaf.
Furthermore, liquid outlet holes are uniformly formed in the peripheral wall of the stirring cover.
Further, the lower end of the reaction kettle is constructed into a downward-tapered horn-shaped structure, and the on-off mechanism is installed at the central position of the small-diameter end of the horn-shaped structure.
Furthermore, the upper end of the reaction kettle is communicated with a drug feeding port, the upper end of the reaction kettle is communicated with an air pipe, and the air pipe is provided with a gas control valve.
Furthermore, the part of the material pipe, which is located at the bottom of each reaction kettle, is provided with a plurality of via holes, the on-off mechanism comprises an on-off sleeve which is sleeved at the via holes of the material pipe in a sliding manner, an expansion spring is fixedly connected between the on-off sleeve and the inner wall of the bottom of the reaction kettle, the lower end of the on-off sleeve extends out of the bottom of the reaction kettle, a limiting flange which extends outwards along the radial direction of the limiting flange is constructed at the lower end of the on-off sleeve, an air cylinder is installed at the lower end of the reaction kettle, a driving rod of the air cylinder is of a U-shaped structure, and the end part of the driving rod is connected with the limiting flange.
Furthermore, at least two adjusting bolts are uniformly connected to the limiting flange along the circumferential direction of the limiting flange in a threaded manner, and the upper end of each adjusting bolt abuts against the lower end face of the reaction kettle.
Furthermore, one end of each liquid return pipe extending into the reaction kettle is communicated with a flow expansion cover, and the flow expansion cover is movably sleeved outside the material pipe.
Due to the adoption of the structure, compared with the prior art, the invention has the technical progress that: filling corresponding medicine groups into each reaction kettle respectively, injecting a proper amount of reaction water into the corresponding reaction kettles, starting a variable-frequency driving motor, stirring the medicine groups in the corresponding reaction kettles by using each stirring and mixing mechanism, starting a corresponding on-off mechanism after the mixing reaction is complete, enabling the reaction kettles to be mixed to be communicated with a material pipe respectively, starting a circulating pump, pumping mixed liquid in the reaction kettles out through the material pipe, pumping the mixed liquid into the reaction kettles through a liquid return pipe by using the circulating pump, circulating in such a way, and continuously operating the variable-frequency driving motor to finally realize the full mixing and reaction of the mixed liquid among the reaction kettles, and then repeating the actions to realize the mixing of the mixed liquid among the reaction kettles; in conclusion, the invention completes the mixing of a plurality of groups of medicine combinations in one step in the same equipment, and mixes the mixed medicines according to the requirements, thereby reducing the production procedures, reducing the equipment investment, improving the production efficiency, reducing the production cost investment and reducing the personnel allocation.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
In the drawings:
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
FIG. 2 is a structural cross-sectional view of an embodiment of the present invention;
FIG. 3 is an enlarged view of the portion A in FIG. 2;
FIG. 4 is an enlarged view of the portion B in FIG. 2;
FIG. 5 is a partial schematic view of an embodiment of the present invention;
FIG. 6 is a schematic structural view of the mixing mechanism, the diffuser and the on-off mechanism connected to the material pipe according to the embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a stirring and mixing mechanism according to an embodiment of the present invention;
FIG. 8 is a schematic structural diagram of another angle of the stirring and mixing mechanism according to the embodiment of the present invention.
Labeling components: 101-reaction kettle, 102-dosing port, 103-air pipe, 104-fixing frame, 105-material pipe, 106-conducting hole, 107-communicating hole, 108-variable frequency driving motor, 109-adapter, 110-liquid inlet pipe, 111-liquid inlet control valve, 112-inlet pipe joint, 113-inlet control valve, 114-circulating pump, 115-liquid outlet pipe, 119-liquid outlet control valve, 120-liquid return pipe, 121-liquid return control valve, 122-outlet pipe joint, 123-outlet control valve, 124-stirring cover, 125-upper rotating vane, 126-drainage stirring vane, 128-flow expansion cover, 129-on-off cover, 130-limiting flange, 131-expansion spring, 132-adjusting bolt, 133-air cylinder and 134-driving rod.
Detailed Description
Preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are for purposes of illustration and explanation only and are not intended to limit the present invention.
The invention discloses a chiral drug mixing reaction device, as shown in fig. 1-8, comprising a plurality of reaction kettles 101, wherein the reaction kettles 101 are sequentially arranged along the vertical direction and are connected and fixed together through a fixing frame 104, a stirring and mixing mechanism is respectively arranged in each reaction kettle 101, a material pipe 105 sequentially penetrates through each reaction kettle 101 along the axis of the reaction kettle 101 from bottom to top, the material pipe 105 is fixedly connected with each stirring and mixing mechanism, meanwhile, the material pipe 105 is respectively communicated with the bottom of each reaction kettle 101, an on-off mechanism is respectively arranged at the lower end of each reaction kettle 101, the on-off mechanism is used for realizing the on-off between the material pipe 105 and the corresponding reaction kettle 101, the lower end of the material pipe 105 is coaxially connected with an output shaft of a variable frequency driving motor 108, an adapter 109 is rotatably arranged at the lower part of the material pipe 105, a circulating pump 114 is communicated with the material pipe 105 through the adapter 109 through a liquid inlet pipe 110, the circulating pump 114 is communicated with the upper end of the material pipe 105 through a liquid outlet pipe 115, a plurality of liquid return pipes 120 are communicated with the liquid outlet pipe 115, each liquid return pipe 120 extends into the corresponding reaction kettle 101 and is positioned above the stirring and mixing mechanism, liquid return control valves 121, liquid inlet control valves 111 and liquid outlet control valves 119 are respectively installed on the liquid return pipes 120, the liquid inlet pipe 110 and the liquid outlet pipe 115, and the liquid outlet control valves 119 are positioned at the top of the liquid outlet pipe 115. The working principle and the advantages of the invention are as follows: filling corresponding medicine groups into each reaction kettle 101, injecting a proper amount of reaction water into the corresponding reaction kettle 101, starting a variable frequency driving motor 108, stirring the medicine groups in the corresponding reaction kettle 101 through each stirring and mixing mechanism, starting a corresponding on-off mechanism after the mixing reaction is complete, enabling the reaction kettles 101 to be mixed to be communicated with a material pipe 105, starting a circulating pump 114, pumping the mixed liquid in the reaction kettles 101 out through the material pipe 105, pumping the mixed liquid into the reaction kettles 101 through a liquid return pipe 120 through the circulating pump 114, circulating in such a way, and simultaneously continuously operating the variable frequency driving motor 108, finally realizing the full mixing and reaction of the mixed liquid among the reaction kettles 101, and then repeating the actions to realize the mixing of the mixed liquid among the reaction kettles 101; in conclusion, the invention completes the mixing of a plurality of groups of medicine combinations in one step in the same equipment, and mixes the mixed medicines according to the requirements, thereby reducing the production procedures, reducing the equipment investment, improving the production efficiency, reducing the production cost investment and reducing the personnel allocation.
As a preferred embodiment of the present invention, as shown in fig. 2-3 and fig. 6-8, the stirring and mixing mechanism includes a stirring cover 124, the stirring cover 124 is fixedly installed on the material pipe 105, the stirring cover 124 is overlapped with the axis of the material pipe 105, a plurality of upper swirling vanes 125 are configured on the inner wall of the stirring cover 124, and the upper swirling vanes 125 are arranged at intervals along the circumferential direction of the stirring cover 124. The working principle and the advantages of the embodiment are as follows: this embodiment is passed through frequency conversion driving motor 108 and is driven the agitator shield 124 rotation through material pipe 105, agitator shield 124 stirs the mixed liquid in to reation kettle 101, in the stirring, owing to be constructed a plurality of whirl leaves 125 on the inner wall at agitator shield 124, thus, make the mixed liquid in the agitator shield 124 move from bottom to top, and outside the up end by agitator shield 124 flows to agitator shield 124, and the mixed liquid outside agitator shield 124 is stirred and moves down gradually until getting into agitator shield 124 lower extreme, and then realize mixed liquid and form the circulation inside and outside agitator shield 124, and then realized that the medicine mixes in reation kettle 101 high-efficiently, from this the homogeneity of mixing has been promoted. In this embodiment, in order to make the mixed liquid in the stirring cover 124 swirl and then turn out of the upper end of the stirring cover 124, as shown in fig. 7, the radial length of the stirring cover 124 gradually increases upward along the axial direction of the material pipe 105. Further, each upper swirling vane 125 extends from the lower end of the stirring hood 124 to the upper end of the stirring hood 124, so that the mixed liquid maintains a continuous swirling flow in the stirring hood 124.
As a preferred embodiment of the present invention, in order to improve the circulation of the mixed liquid inside and outside the stirring cover 124 and simultaneously improve the mixing effect of the mixed liquid inside the stirring cover 124, as shown in fig. 7, a plurality of drainage stirring blades 126 are installed inside the stirring cover 124, the drainage stirring blades 126 are uniformly arranged along the circumferential direction of the material pipe 105, and one end of each drainage stirring blade 126 is fixedly connected to the corresponding upper rotating blade 125, so that during the rotation of the stirring cover 124, the drainage stirring blade 126 rotates along with the rotation of the drainage stirring blade 126 and drives the mixed liquid below the drainage stirring blade upwards, and simultaneously, the drainage stirring blade 126 stirs the mixed liquid swirled by the rotation of the upper rotating blade 125, thereby completing the dual functions of drainage and mixing. In this embodiment, for making a part of the mixed liquid of the internal rotational flow of the stirring cover 124 jet out of the stirring cover 124 at different positions of the stirring cover 124, so that the mixed liquid outside the stirring cover 124 and the corresponding jet mixed liquid form a micro-mixing effect, and further improve the mixing sufficiency, a specific measure is, as shown in fig. 8, liquid outlet holes are uniformly formed in the peripheral wall of the stirring cover 124, and the mixed liquid is jetted out from the liquid outlet holes.
In a preferred embodiment of the present invention, the lower end of the reaction vessel 101 is formed in a downwardly tapered trumpet-like configuration as shown in fig. 1 to 2, in order to facilitate the liquid discharge and to improve the smoothness of the circulation of the mixed liquid by the driving of the stirring hood 124. Further, the on-off mechanism is installed at a central position of the small diameter end of the horn-like structure. The upper end of the reaction kettle 101 is communicated with a drug feeding port 102 for feeding drugs; the upper end of the reaction vessel 101 is connected to a gas pipe 103, and a gas control valve is installed on the gas pipe 103 for the purpose of discharging the gas in the reaction vessel 101, and the gas pipe 103 can also be used for pressurizing and depressurizing the reaction vessel 101 to achieve sufficient reaction of the drug in a desired reaction environment.
As a preferred embodiment of the present invention, in order to pump the reaction water (clean water) into each reaction tank 101 simultaneously or sequentially by the circulation pump 114, as shown in fig. 1-2, an inlet pipe connector 112 is connected to the inlet pipe 110 and behind the valve of the inlet control valve 111, an inlet control valve 113 is installed on the inlet pipe connector 112, and the inlet control valve 113 is opened by closing the inlet control valve 111, so as to pump the reaction water into each reaction tank 101 through the inlet pipe connector 112 by the circulation pump 114. In order to facilitate discharging the chiral drug mixed liquid from each reaction vessel 101 to the collecting device, the outlet pipe joint 122 is connected to the outlet pipe 115 and in front of the valve of the liquid outlet control valve 119, the outlet pipe joint 122 is provided with the outlet control valve 123, and the outlet control valve 123 is opened by closing the liquid outlet control valve 119 and the inlet control valve 113, so that the chiral drug mixed liquid is pumped into the collecting device through the circulating pump 114.
As a preferred embodiment of the present invention, as shown in fig. 4, a communication hole 107 is formed at a lower position of the material pipe 105, an adapter 109 is installed at the communication hole 107 of the material pipe 105, the adapter 109 is rotatably connected with the material pipe 105, and the liquid inlet pipe 110 is communicated with the adapter 109. The liquid inlet pipe 110 is communicated with the material pipe 105 through the adapter 109 and the communication hole 107.
As a preferred embodiment of the present invention, as shown in fig. 2-3 and 5-6, a plurality of through holes 106 are opened at a portion of the material pipe 105 located at the bottom of each reaction vessel 101, the above-mentioned on-off mechanism includes an on-off sleeve 129, the on-off sleeve 129 is slidably sleeved at the through holes 106 of the material pipe 105, a telescopic spring 131 is fixedly connected between the on-off sleeve 129 and the inner wall of the bottom of the reaction vessel 101, the lower end of the on-off sleeve 129 extends out of the bottom end of the reaction vessel 101, a limit flange 130 extending radially outward is configured at the lower end of the on-off sleeve 129, a cylinder 133 is installed at the lower end of the reaction vessel 101, a driving rod 134 of the cylinder 133 is U-shaped, and the end of the driving rod 134 is connected with the limit flange 130. The driving rod 134 is driven to move through the cylinder 133, so that the on-off sleeve 129 moves along the axial direction of the material pipe 105, the through hole 106 is communicated or separated with the inside of the reaction kettle 101, and the on-off of the material pipe 105 and the reaction kettle 101 is realized. In order to facilitate manual adjustment of the on-off sleeve 129 to enable the on-off sleeve 129 to achieve an on-off function, specifically, at least two adjusting bolts 132 are uniformly connected to the limiting flange 130 along the circumferential direction of the limiting flange, the upper end of each adjusting bolt 132 abuts against the lower end face of the reaction kettle 101, the on-off sleeve 129 is lifted by rotating the adjusting bolts 132, and the on-off sleeve 129 is shielded or exposed out of the conducting hole 106.
As a preferred embodiment of the present invention, in order to make the liquid returned from the liquid return pipe 120 to the reaction vessel 101 interact with the liquid stirred by the stirring and mixing mechanism, so as to improve the uniformity and the sufficiency of the mixing reaction, as shown in fig. 2 and fig. 6, a flow expansion cover 128 is connected to one end of each liquid return pipe 120 extending into the reaction vessel 101, the flow expansion cover 128 is movably sleeved outside the material pipe 105, the liquid is sprayed in an umbrella shape from the liquid return pipe 120 through the flow expansion cover 128 above the stirring and mixing mechanism, and the liquid stirred by the stirring and mixing mechanism contacts with the spiral lifting shape, so that the mixing of the liquid is more sufficient.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (10)
1. A chiral medicine mixing reaction device is characterized in that: the device comprises a plurality of reaction kettles which are sequentially arranged along the vertical direction and are fixedly connected through a fixing frame, stirring and mixing mechanisms are respectively arranged in each reaction kettle, a material pipe sequentially penetrates through each reaction kettle from bottom to top along the axis of each reaction kettle and is fixedly connected with each stirring and mixing mechanism, the material pipe is respectively communicated with the bottom of each reaction kettle and is communicated with the corresponding reaction kettle through an on-off mechanism arranged at the lower end of each reaction kettle, the lower end of the material pipe is coaxially connected with an output shaft of a variable frequency driving motor, a rotating part is rotatably arranged at the lower part of the material pipe, a circulating pump is communicated with the material pipe through a liquid inlet pipe and a rotating part, the circulating pump is communicated with the upper end of the material pipe through a liquid outlet pipe, a plurality of liquid return pipes are communicated with the liquid outlet pipe, each liquid return pipe respectively extends into the corresponding reaction kettle and is positioned above the stirring and mixing mechanisms, and liquid return control valves are respectively arranged on the liquid return pipes, the liquid inlet pipe and the liquid outlet pipe, The liquid inlet control valve and the liquid outlet control valve are positioned at the top of the liquid outlet pipe.
2. The chiral drug mixing reaction device according to claim 1, wherein: the stirring and mixing mechanism comprises a stirring cover fixedly arranged on the material pipe, the stirring cover is superposed with the axis of the material pipe, a plurality of upper swirling vanes are constructed on the inner wall of the stirring cover, and the upper swirling vanes are arranged at intervals along the circumferential direction of the stirring cover.
3. The chiral drug mixing reaction device according to claim 2, wherein: the radial length of the stirring cover is gradually enlarged upwards along the axial direction of the mounting rod, and each upper swirling vane extends from the lower end of the stirring cover to the upper end of the stirring cover.
4. The chiral drug mixing reaction device according to claim 2, wherein: a plurality of drainage stirring blades are installed in the stirring cover, the drainage stirring blades are uniformly arranged along the circumferential direction of the installation rod, and one end of each drainage stirring blade is fixedly connected with the corresponding upper swirling blade.
5. The chiral drug mixing reaction device according to claim 2, wherein: liquid outlet holes are uniformly formed in the peripheral wall of the stirring cover.
6. The chiral drug mixing reaction device according to claim 1, wherein: the lower end of the reaction kettle is constructed into a horn-shaped structure which is reduced downwards, and the on-off mechanism is arranged at the central position of the small-diameter end of the horn-shaped structure.
7. The chiral drug mixing reaction device according to claim 1, wherein: the upper end of the reaction kettle is communicated with a drug feeding port, the upper end of the reaction kettle is communicated with an air pipe, and the air pipe is provided with a gas control valve.
8. The chiral drug mixing reaction device according to claim 1, wherein: the material pipe is located the part of each reation kettle bottom position department and has seted up a plurality of conducting holes, on-off mechanism includes the break-make cover of slip suit in the conducting hole department of material pipe, link firmly a expanding spring between the inner wall of break-make cover and reation kettle bottom, the lower extreme of break-make cover stretches out reation kettle's bottom, constructs at the lower extreme of break-make cover to have along its radial outside limit flange who extends, installs the cylinder in reation kettle's lower extreme, the actuating lever of cylinder is U type structure, the tip and the limit flange of actuating lever are connected.
9. The chiral drug mixing reaction device of claim 8, wherein: and at least two adjusting bolts are uniformly and spirally connected to the limiting flange along the circumferential direction of the limiting flange, and the upper end of each adjusting bolt abuts against the lower end face of the reaction kettle.
10. A chiral drug mixing reaction device according to any one of claims 1 to 9, wherein: and one end of each liquid return pipe extending into the reaction kettle is communicated with a flow expansion cover, and the flow expansion cover is movably sleeved outside the material pipe.
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| CN202111061509.3A CN113731333A (en) | 2021-09-10 | 2021-09-10 | Chiral medicine mixing reaction device |
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| CN202111061509.3A CN113731333A (en) | 2021-09-10 | 2021-09-10 | Chiral medicine mixing reaction device |
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Application publication date: 20211203 |