CN113730829A - Real-time image guiding method - Google Patents
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- 238000000034 method Methods 0.000 title claims abstract description 44
- 238000001514 detection method Methods 0.000 claims abstract description 26
- 238000001914 filtration Methods 0.000 claims abstract description 17
- 238000003384 imaging method Methods 0.000 claims abstract description 17
- 238000001959 radiotherapy Methods 0.000 claims description 23
- 230000005855 radiation Effects 0.000 abstract description 13
- 230000001360 synchronised effect Effects 0.000 abstract description 9
- 206010028980 Neoplasm Diseases 0.000 description 5
- 238000006073 displacement reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002786 image-guided radiation therapy Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
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Abstract
The invention discloses a real-time image guiding method, which relates to the technical field of real-time image guiding and comprises the following steps: emitting a first ray to a detection plate through a ray generator of an X-ray image guiding system to obtain a first image; the first ray is a kV-level X ray, and the pulse interval t of the first ray is longer than the imaging time of the detection plate; filtering and denoising the first image to obtain a third image; acquiring a second image; the second image is an image generated by the detection plate within the pulse interval t of the first ray; filtering and denoising the second image to obtain a fourth image; and subtracting the third image from the fourth image to obtain a fifth image. The real-time image guiding method disclosed by the invention can realize synchronous real-time X-ray image guiding in the radiation treatment process, improves the treatment accuracy, and has small realization difficulty and low cost.
Description
The invention relates to a divisional application of a real-time image guidance technical method, wherein the application number of a parent application is 201910089230.2, and the application date is 2019.01.30.
Technical Field
The invention relates to the technical field of real-time image guidance, in particular to a method for real-time image guidance.
Background
Radiotherapy (radiotherapy for short) is an important one of tumor treatment methods, and precise radiotherapy is an important development direction in the field of radiotherapy. In order to ensure that the Radiation is accurately irradiated onto the target region of the tumor during the radiotherapy execution, Image Guided Radiation Therapy (IGRT) is generally used according to the clinical requirement. The image guidance is to locate and track the position of the target area of a patient by an imaging device such as an X-ray and the like before and during treatment so as to ensure that the ray always irradiates on the target area of the tumor accurately and the normal organs around the tumor receive irradiation as low as possible.
At present, image guidance used in the radiotherapy industry mainly comprises several technologies such as nuclear magnetic image guidance, optical image guidance, X-ray image guidance and the like. The nuclear magnetic image guidance has the advantages of high soft tissue resolution, synchronous real-time imaging in the radiotherapy process and the like, but the cost is extremely high, and the nuclear magnetic image guidance is not popularized on a large scale at present. The optical image guidance has the advantages of relatively low price, synchronous real-time imaging in the radiotherapy process and the like, but only can track the motion displacement of the body surface of a patient and cannot detect and track the real motion displacement of a tumor target area in the body of the patient. X-ray image guidance has the advantages of accurate spatial positioning, high imaging quality, relatively low price and the like, but since the radiation used for radiotherapy is generally MV-grade X-rays, X-ray image guidance systems generally use kV-grade X-rays. The scattered ray generated by MV-grade rays of radiotherapy can greatly influence the signal acquisition and imaging of the kV-grade X-ray image guide system, so that the technical difficulty of realizing synchronous real-time imaging in the radiotherapy process of the kV-grade X-ray image guide system is higher.
Therefore, a real-time image guidance method is needed, which is based on the existing X-ray image guidance system to achieve synchronous real-time X-ray image guidance during the radiotherapy process, so as to improve the treatment accuracy.
Disclosure of Invention
The invention aims to provide a real-time image guiding method, which realizes synchronous real-time X-ray image guiding in the process of radiotherapy and improves the treatment accuracy.
In order to achieve the purpose, the invention provides the following scheme:
a method of real-time image guidance, comprising:
emitting a first ray to a detection plate through a ray generator of an X-ray image guiding system to obtain a first image; the first ray is a kV-level X ray, and the pulse interval t of the first ray is longer than the imaging time of the detection plate;
filtering and denoising the first image to obtain a third image;
acquiring a second image; the second image is an image collected by the detection plate within the pulse interval t of the first ray;
filtering and denoising the second image to obtain a fourth image;
and subtracting the third image from the fourth image to obtain a fifth image.
Optionally, the pulse interval t of the first ray is set by control software.
Optionally, the radiation generator is a pulsed radiation generator.
Optionally, the real-time image guidance method further includes:
and carrying out filtering and denoising operation on the fifth image.
In order to achieve the purpose, the invention also provides the following technical scheme:
a method of real-time image guidance, comprising:
firstly, selecting a pulse type ray generator in a kV-level X-ray image guide system, and setting the pulse interval of the generated kV-level X-ray to be t through control software; the pulse interval t of the kV-level X-ray is larger than the time required by imaging of the detection plate;
secondly, in the MV-level X-ray irradiation treatment process, a pulse type ray generator in the kV-level X-ray image guiding system emits kV-level X-rays to the detection plate to generate a first image; the first image is formed by the combined action of kV-level X-rays generated by a pulse type ray generator in the kV-level X-ray image guiding system and scattered rays generated by MV-level rays in the MV-level X-ray irradiation treatment process;
thirdly, the control software controls the detection plate to normally work within the pulse interval t of the kV-level X-ray image guidance system to generate a second image; the second image is formed by the action of scattered rays generated by MV-level rays in the MV-level X-ray irradiation treatment process;
fourthly, subtracting the first image obtained in the second step from the second image obtained in the third step to obtain a sixth image; the sixth image is generated by the action of kV-level X-rays generated by a pulse type ray generator in the kV-level X-ray image guidance system, and the sixth image is used for carrying out image guidance operation of radiotherapy.
Optionally, filtering and denoising operations are added in the second step, the third step and the fourth step, respectively.
According to the specific embodiment provided by the invention, the invention discloses the following technical effects:
emitting a first ray to a detection plate through a ray generator of an X-ray image guiding system to obtain a first image, wherein the first image is formed by the combined action of the first ray and scattered rays generated by MV-level rays in the MV-level X-ray irradiation treatment process; filtering and denoising the first image to obtain a third image; acquiring an image generated by the detection plate within the pulse interval t of the first ray, namely a second image, wherein the second image is formed by the independent action of scattered rays generated by MV-grade rays in the MV-grade X-ray irradiation treatment process; filtering and denoising the second image to obtain a fourth image; and finally, subtracting the third image from the fourth image to obtain a fifth image, wherein the fifth image is formed by the independent action of the first ray. The invention can perform real-time and synchronous X-ray image guidance in the radiotherapy process, improves the treatment precision, and has the advantages of low implementation difficulty and low cost.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other structural schematic diagrams according to these drawings without inventive labor.
FIG. 1 is a flowchart illustrating a method for real-time image guidance according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention aims to provide a real-time image guiding method, which realizes synchronous real-time X-ray image guiding in the process of radiotherapy and improves the treatment accuracy.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
The X-ray image guiding system generally comprises a high-voltage module, an X-ray generator and a detection plate, and the working principle is that the X-ray generator emits X-rays under the power supply action of the high-voltage module, and the X-rays are absorbed and detected by the detection plate after being attenuated and absorbed by a medium. The detection plate can generate corresponding X-ray images according to the energy spectrum and distribution of the detected rays.
Example one
As shown in fig. 1, the present embodiment provides a method for real-time image guidance, including:
And 200, filtering and denoising the first image to obtain a third image.
And 400, filtering and denoising the second image to obtain a fourth image.
And 500, subtracting the third image from the fourth image to obtain a fifth image.
In this embodiment, the method for real-time image guidance further includes: and carrying out filtering and denoising operation on the fifth image.
Example two
The radiation applicable to the actual clinical radiotherapy of the present embodiment includes various kinds of radiation such as electron beam, X-ray, proton beam, and the like.
The technical principle of the present embodiment will be described below by taking as an example the implementation of real-time image guidance during MV-level X-ray radiotherapy using a kV-level X-ray image guidance system.
In the 1 kV-level X-ray image guidance system, a pulse type ray generator is selected, namely, the generated X-rays are in a pulse mode. Let the pulse interval of the generated X-ray be t, and set the size of t in the control software to be larger than the time required for imaging the detection plate.
2. During the X-ray irradiation treatment process, a ray generator of the X-ray image guide system works normally to generate X-rays, and the detection plate works normally to generate a first image. As can be seen from the imaging principle, the first image is generated by the combined action of the X-rays generated by the X-ray image guidance system and the scattered radiation generated by the MV-level radiation of the radiotherapy. The first image typically does not show normal anatomical information and cannot be used directly.
3. And in the pulse interval time period of the X-ray image guide system, the system control software controls the detection plate to normally work to generate a second image. As can be seen from the imaging principles, the second image is affected by scattered radiation generated by the radiation of the radiation therapy at MV level. The second image also typically does not show normal anatomical information nor is it directly usable.
4. And (3) according to the linear time-invariant characteristic of the X-ray imaging, carrying out subtraction operation on the first image obtained in the step (2) and the second image obtained in the step (3) to obtain a sixth image. As can be seen from the imaging principle, the sixth image is a result of the X-ray effect produced by the X-ray image guidance system, and the scattered radiation effect produced by the MV-level radiation of the radiotherapy is subtracted. The sixth image can display normal anatomical information and can be used directly for image-guided operation of radiotherapy.
The above steps are the technical principle of the present invention, and image processing operations such as filtering and denoising may need to be added in actual operation. The related image processing operations such as filtering, denoising and the like are conventional technical operations and can be realized by related professionals.
Compared with the prior art, the invention also has the following advantages:
the invention overcomes the defects of the prior art, provides a technical method for real-time image guidance, and has small realization difficulty and low cost; and in the radiation treatment process, synchronous real-time X-ray image guidance can be realized, and the treatment accuracy is improved.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The principles and embodiments of the present invention have been described herein using specific examples, which are provided only to help understand the method and the core concept of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (6)
1. A real-time image-guided method, characterized in that the real-time image-guided method comprises:
emitting a first ray to a detection plate through a ray generator of an X-ray image guiding system to obtain a first image; the first ray is a kV-level X ray, and the pulse interval t of the first ray is longer than the imaging time of the detection plate;
filtering and denoising the first image to obtain a third image;
acquiring a second image; the second image is an image collected by the detection plate within the pulse interval t of the first ray;
filtering and denoising the second image to obtain a fourth image;
and subtracting the third image from the fourth image to obtain a fifth image.
2. A method of real-time image-guided according to claim 1, characterized in that the pulse interval t of the first ray is set by control software.
3. A real-time image-guided method according to claim 1, wherein the ray generator is a pulsed ray generator.
4. The real-time image-guided method according to claim 1, further comprising:
and carrying out filtering and denoising operation on the fifth image.
5. A real-time image-guided method, characterized in that the real-time image-guided method comprises:
firstly, selecting a pulse type ray generator in a kV-level X-ray image guide system, and setting the pulse interval of the generated kV-level X-ray to be t through control software; the pulse interval t of the kV-level X-ray is larger than the time required by imaging of the detection plate;
secondly, in the MV-level X-ray irradiation treatment process, a pulse type ray generator in the kV-level X-ray image guiding system emits kV-level X-rays to the detection plate to generate a first image; the first image is formed by the combined action of kV-level X-rays generated by a pulse type ray generator in the kV-level X-ray image guiding system and scattered rays generated by MV-level rays in the MV-level X-ray irradiation treatment process;
thirdly, the control software controls the detection plate to normally work within the pulse interval t of the kV-level X-ray image guidance system to generate a second image; the second image is formed by the action of scattered rays generated by MV-level rays in the MV-level X-ray irradiation treatment process;
fourthly, subtracting the first image obtained in the second step from the second image obtained in the third step to obtain a sixth image; the sixth image is generated by the action of kV-level X-rays generated by a pulse type ray generator in the kV-level X-ray image guidance system, and the sixth image is used for carrying out image guidance operation of radiotherapy.
6. A real-time image-guided technique as claimed in claim 5, wherein filtering and denoising operations are added in the second, third and fourth steps, respectively.
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| CN201910089230.2A CN109646821A (en) | 2019-01-30 | 2019-01-30 | A kind of technical method of realtime graphic guidance |
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| US20040251420A1 (en) * | 2003-06-14 | 2004-12-16 | Xiao-Dong Sun | X-ray detectors with a grid structured scintillators |
| CN102549586A (en) * | 2009-10-02 | 2012-07-04 | 瓦润医药系统国际股份公司 | Systems and methods for obtaining reconstructed images during a treatment session |
| CN104065889A (en) * | 2014-06-25 | 2014-09-24 | 山东大学 | Pseudo dual energy X-ray line array imaging system |
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| EP1846752A2 (en) * | 2005-02-01 | 2007-10-24 | Koninklijke Philips Electronics N.V. | Apparatus and method for correction or extension of x-ray projections |
| US9125286B2 (en) * | 2012-12-28 | 2015-09-01 | General Electric Company | X-ray dose estimation technique |
| CN105427355B (en) * | 2015-11-26 | 2018-04-03 | 上海联影医疗科技有限公司 | The method and device that case, the scattering composition of radioscopic image are calculated, rebuild |
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| US20040251420A1 (en) * | 2003-06-14 | 2004-12-16 | Xiao-Dong Sun | X-ray detectors with a grid structured scintillators |
| CN102549586A (en) * | 2009-10-02 | 2012-07-04 | 瓦润医药系统国际股份公司 | Systems and methods for obtaining reconstructed images during a treatment session |
| CN104065889A (en) * | 2014-06-25 | 2014-09-24 | 山东大学 | Pseudo dual energy X-ray line array imaging system |
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