CN113730055A - Intravascular stent and intravascular nerve stimulation system - Google Patents
Intravascular stent and intravascular nerve stimulation system Download PDFInfo
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- CN113730055A CN113730055A CN202111164818.3A CN202111164818A CN113730055A CN 113730055 A CN113730055 A CN 113730055A CN 202111164818 A CN202111164818 A CN 202111164818A CN 113730055 A CN113730055 A CN 113730055A
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- A61N1/02—Details
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- A61N1/0551—Spinal or peripheral nerve electrodes
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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Abstract
The present application relates to an intravascular stent and an intravascular nerve stimulation system, comprising: a stent implantable inside a target vessel; the nano piezoelectric layer comprises a plurality of nano power generation units, the nano power generation units are arranged on the surface of the support through a plurality of grooves formed in the surface of the support, and the nano power generation units can convert received ultrasonic mechanical energy into electric energy to stimulate nerves in the wall of a target blood vessel. Realize medical personnel and need not to consider the energy problem of nanometer piezoelectric layer, can carry out energy supply from the external when needing amazing relevant nerve, fully reduce the operation risk, but convenient and fast stimulates and treats the patient, and through controlling ultrasonic wave generating device, makes its ultrasonic wave that can produce different intensity, and then control nanometer piezoelectric layer and produce the stimulation of different degrees to relevant nerve, and the medical personnel of being convenient for carry out the adaptability treatment to the patient.
Description
Technical Field
The present application relates to the field of medical devices, and in particular, to an intravascular stent and an intravascular nerve stimulation system.
Background
The nervous system of the body is a dynamic balance system composed of electric signals and chemical signals, and under the influence of external factors, the balance is broken, thereby promoting the occurrence and development of diseases. Therefore, restoration of this dynamic equilibrium state by regulation of the body's nervous system can prevent the occurrence of diseases.
Direct or indirect stimulation of the spleen nerve can activate the downstream cholinergic anti-inflammatory pathway (C intravascular stent system P) and inhibit inflammation and disease progression. Researches show that the spleen nerve stimulation can obviously reduce the levels of anti-inflammatory factors such as TNF-alpha, IL-1 beta, IL-6 and the like, inhibit the progress of inflammation-mediated disease damage, and provide a new strategy for treating multiple system diseases such as myocardial ischemia, heart failure, hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, diabetes, Alzheimer disease, multiple sclerosis, cerebral ischemia and the like.
In addition, stimulation of peripheral sympathetic nerves, such as those associated with the heart, lung, liver, kidney, intestine, muscle, etc., may also promote the contraction and relaxation functions of the target vessels, promoting the reestablishment of vascular homeostasis and other physiological functions. The spinal nerve stimulation can also be used for treating chronic pain, cerebral ischemia, dystonia, tremor, multiple sclerosis, Parkinson's disease, neuropsychiatric diseases and the like, and in addition, the activation of baroreceptors such as carotid sinus and the like can also achieve the purpose of preventing and treating diseases by enhancing the activity of vagus nerve and reducing the activity of sympathetic nerve and finally restoring the balance of autonomic nerve.
However, the existing implantable neurostimulation device has the defects of large battery size, short service life and the like, and the battery replacement brings great inconvenience to patients, and even increases the disease risk and economic burden of patients due to corresponding operations, so the defects of the implantable neurostimulation device in the aspects of energy supply, wound and the like seriously hinder the progress of the implantable neurostimulation device.
Disclosure of Invention
The embodiment of the application provides an intravascular stent and an intravascular nerve stimulation system, which are used for solving the problems of difficult energy supply and inconvenient use of a nerve stimulation device in a human body in the related art.
In a first aspect, an intravascular stent is provided, which adopts the following scheme:
an intravascular stent, comprising:
a stent implantable inside a target vessel;
a nano piezoelectric layer including a plurality of nano power generation units, the nano power generation units being mounted on the surface of the support through a plurality of grooves arranged on the surface of the support,
the nano power generation unit can convert the received ultrasonic mechanical energy into electric energy for stimulating nerves in the wall of a target blood vessel.
By the scheme, when the stent arranged in the target blood vessel supports the target blood vessel, the nano piezoelectric layer on the surface of the stent can vibrate under the action of ultrasonic waves generated by an external ultrasonic generating device and further generates current on the stent, the generated current can finally act on related nerves in the wall of the target blood vessel, so that the related parts of a patient can be quickly and directly stimulated, the ultrasonic generating device can be controlled to generate ultrasonic waves with different intensities, the nano piezoelectric layer is further controlled to generate stimulation of different degrees on the related nerves, and medical staff can conveniently perform adaptive treatment on the patient;
meanwhile, the nanometer power generation unit can be more stably arranged on the surface of the bracket by virtue of the groove, so that the nanometer power generation unit can smoothly enter a target blood vessel along with the bracket to act; when the current is transmitted by the support, the nano power generation unit is positioned in the groove, so that the nano power generation unit has a larger contact area with the support, and can be fully transmitted to the support after generating the current, and finally, related nerves in a target blood vessel contacted by the support are smoothly stimulated.
In some embodiments, the nano-piezoelectric layer is fully degradable in the human body.
Through above-mentioned scheme, the nanometer piezoelectric layer need not take out it after the treatment is finished following the support and putting into the patient internal back, can degrade naturally after the certain time, reduces the relevant operation among the treatment process, the subsequent recovery of the patient of being convenient for.
In some embodiments, the nano-power generation unit employs a degradable polymer, and may employ one or more of poly-L-lactide-co-glycolide, poly-3-hydroxybutyrate-co-3-hydroxyvalerate, polycaprolactone, and polyvinyl alcohol.
In some embodiments, the nano-piezoelectric layer is provided with an outer protective coating on the surface, and the stent is a conductive stent.
Through above-mentioned scheme, outer protective coating can further ensure the stability of nanometer piezoelectric layer on the support on nanometer piezoelectric layer surface, avoids the support to drop from the support when the nanometer piezoelectric layer removes in the target blood vessel, and the support adopts the electric conductivity support simultaneously, can make the produced electric current of nanometer piezoelectric layer pass through the support and transmit the pipe wall to the target blood vessel, and then the relevant nerve of smooth amazing target blood vessel.
In some embodiments, the outer jacket layer may be completely degradable within the human body.
By the scheme, the outer protective coating can be naturally and completely degraded in a human body, and potential safety hazards existing in the human body for a long time are avoided.
In some embodiments, the outer protective coating is any one of methyl acrylate, polylactic acid, chondroitin sulfate, and phosphorylcholine.
Through the scheme, the selected materials have good blood-biocompatibility, so that inflammatory reaction and thrombosis can be avoided, and the materials are prevented from falling off from the stent.
In some embodiments, the stent may be fully degradable within the human body.
Through above-mentioned scheme, realize the support can be after long-time in human natural degradation, avoid the later stage to take out.
In some embodiments, the scaffold is a Zn-Cu alloy scaffold.
By adopting the scheme, the Zn-Cu alloy which can be naturally absorbed by a human body is adopted as the stent material, so that trace elements of the human body are supplemented while the stent is effectively degraded and absorbed.
In some embodiments, the scaffold has an open mesh structure.
Through above-mentioned scheme, effectively reduce the weight of support, alleviate patient's burden, also make the support have better deformability simultaneously, conveniently implant in the target blood vessel and follow-up strutting after the compression.
In a second aspect, an intravascular nerve stimulation system is provided, which employs the following scheme:
an intravascular nerve stimulation system, comprising:
an intravascular stent as described above;
an ultrasonic wave generating device for ultrasonically vibrating the intravascular stent implanted inside a target blood vessel.
The beneficial effect that technical scheme that this application provided brought includes:
the embodiment of the application provides an intravascular stent and an intravascular nerve stimulation system, and the intravascular stent is arranged in a target blood vessel, the nano piezoelectric layer on the surface can vibrate under the action of ultrasonic waves generated by an external ultrasonic wave generating device, and further generates current on the nano piezoelectric layer, and the generated current can finally act on related nerves in the wall of the target blood vessel, so that medical care personnel do not need to consider the energy problem of the nano piezoelectric layer, can supply energy from the outside of the body when related nerves need to be stimulated, fully reduces the operation risk, can conveniently and quickly stimulate and treat patients, can generate ultrasonic waves with different intensities by controlling the ultrasonic wave generating device, and then the nano piezoelectric layer is controlled to generate stimulation of different degrees to related nerves, so that medical personnel can carry out adaptive treatment on the patient conveniently.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic view of an intravascular stent provided in an embodiment of the present application;
fig. 2 is a cross-sectional view of an intravascular stent provided in accordance with an embodiment of the present application;
fig. 3 is a schematic diagram of an intravascular nerve stimulation system provided by an embodiment of the present application.
In the figure:
1. a support; 10. a groove;
2. a nano-piezoelectric layer; 20. a nano-power generation unit;
3. an outer protective coating;
4. an ultrasonic wave generating device.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the application provides an intravascular stent and an intravascular nerve stimulation system, which can solve the problems of difficult energy supply and inconvenient use of a nerve stimulation device in a human body in the related art.
In a first aspect, the present application provides an intravascular stent comprising:
a stent 1 implantable inside a target blood vessel;
the nano piezoelectric layer 2 comprises a plurality of nano power generation units 20, the nano power generation units 20 are arranged on the surface of the bracket 1 through a plurality of grooves 10 arranged on the surface of the bracket 1,
the nano-power generation unit 20 can convert the received ultrasonic mechanical energy into electric energy for stimulating nerves in the wall of the target blood vessel.
When the stent 1 arranged in the target blood vessel supports the target blood vessel, the nano piezoelectric layer 2 on the surface can vibrate under the action of ultrasonic waves generated by the external ultrasonic wave generating device 4 and further generates current on the stent, the generated current can finally act on related nerves in the wall of the target blood vessel, so that the related parts of a patient can be quickly and directly stimulated, the ultrasonic wave generating device 4 can be controlled to generate ultrasonic waves with different intensities, and the nano piezoelectric layer 2 is further controlled to generate stimulation of different degrees on the related nerves, so that medical personnel can conveniently perform adaptive treatment on the patient;
meanwhile, the nanometer power generation unit 20 can be more stably arranged on the surface of the bracket 1 by virtue of the groove 10, so that the nanometer power generation unit can smoothly enter a target blood vessel along with the bracket 1 to act; when the current is transmitted by the stent 1, the nano power generation unit 20 is positioned in the groove 10, so that the nano power generation unit has a larger contact area with the stent 1, and can be fully transmitted to the stent 1 after generating the current, and finally, related nerves in a target blood vessel contacted with the stent 1 can be smoothly stimulated.
Set up like this, realize that medical personnel need not to consider the energy problem of nanometer piezoelectric layer 2, can carry out energy supply from the external when needing amazing relevant nerve, fully reduce the operation risk, but convenient and fast stimulates and treats the patient.
Alternatively, the nano-piezoelectric layer 2 can be completely degraded in the human body.
Set up like this, nanometer piezoelectric layer 2 need not take out it after the treatment is finished after following support 1 and putting into the patient internal, can degrade naturally after the certain time, reduces the relevant operation among the treatment process, the subsequent recovery of the patient of being convenient for.
Alternatively, the nano-power generation unit 20 may employ a degradable polymer, and may employ one or more of poly L-lactide-co-glycolide, poly 3-hydroxybutyrate-co-3-hydroxyvalerate, polycaprolactone, and polyvinyl alcohol.
Optionally, an outer protective coating 3 is disposed on the surface of the nano piezoelectric layer 2, and the stent 1 is a conductive stent 1.
Set up like this, outer protective coating 3 can further ensure the stability of nanometer piezoelectric layer 2 on support 1 on 2 surfaces of nanometer piezoelectric layer, and nanometer piezoelectric layer 2 drops from support 1 when avoiding support 1 to remove in the target blood vessel, and support 1 adopts electrically conductive support 1 simultaneously, can make the produced electric current of nanometer piezoelectric layer 2 pass through support 1 and transmit to the pipe wall of target blood vessel, and then stimulate the relevant nerve in the target blood vessel smoothly.
Alternatively, the outer protective coating 3 may be completely degradable in the human body.
Wherein, the outer protective coating 3 can be degraded naturally and completely in human body, thereby avoiding potential safety hazard existing in human body for a long time.
Optionally, the outer protective coating 3 is any one of methyl acrylate, polylactic acid and chondroitin sulfate.
By adopting the arrangement, the selected materials have better blood-biocompatibility, can avoid inflammatory reaction and thrombosis, and prevent the materials from falling off from the stent 1.
Alternatively, the stent 1 may be completely degradable in the human body.
By the arrangement, the support 1 can be naturally degraded in a human body after a long time, and the need of taking out the support in the later period is avoided.
Optionally, the support 1 is in a hollow mesh structure.
By the arrangement, the weight of the support 1 is effectively reduced, the burden of a patient is reduced, and meanwhile, the support 1 has better deformation capacity, is conveniently implanted into a target blood vessel after being compressed and is subsequently unfolded.
In a second aspect, with reference to fig. 3, the present application provides an intravascular nerve stimulation system comprising:
an intravascular stent as described above;
an ultrasonic generator 4 for ultrasonically vibrating the intravascular stent implanted inside a target blood vessel.
Wherein, install the intravascular stent inside the target blood vessel and support the same time to the target blood vessel, the nanometer piezoelectric layer 2 on its surface can vibrate under the ultrasonic effect that the ultrasonic wave generating device 4 of outside produced to further produce the electric current on it, produced electric current finally can act on the relevant nerve in the target blood vessel pipe wall, realize swiftly, the directness is amazing relevant position of patient, and through controlling ultrasonic generating device 4, make it can produce the ultrasonic wave of different intensity, and then control nanometer piezoelectric layer 2 and produce the stimulation of different degrees to relevant nerve, the medical personnel of being convenient for carry out the adaptability treatment to the patient.
Based on the principle, when the organism is in a long-term chronic inflammation overactivation state, the blood pressure of a hypertensive patient is unstable, and the drug control is poor; or promoting the progression of chronic heart failure patients or inducing acute attack. Aiming at the patients with the chronic cardiovascular diseases, the intravascular stent provided by the application can be implanted into the splenic artery in an interventional mode, the energy of the nano piezoelectric layer 2 is supplied to be converted into electric energy through in-vitro ultrasonic response, the electric energy is directly stimulated to nerve and can be released for a long time, and the most safe and effective stimulation parameters are selected by changing ultrasonic parameters and combining vital signs of the patients. After the intravascular stent activates the splenic nerve, a downstream splenic cholinergic anti-inflammatory pathway is activated, the release of inflammatory mediators is relieved, the disease progress is delayed, and the intravascular stent is used for long-term adjuvant therapy. Correspondingly, treatment modes such as basic medicines and the like can be applied simultaneously to realize synergistic assistance and improve prognosis.
Meanwhile, long-term stimulation of chronic inflammation can also promote coronary heart disease plaque shedding, diabetes cardiovascular damage and the like, so the intravascular nerve stimulation system can also be applied to various disease models and patient groups accompanied with pathological changes of chronic inflammation.
When a patient with acute myocardial infarction is subjected to percutaneous coronary intervention treatment, ischemia-reperfusion injury is easy to occur after blood vessels are opened, cytokine storm is induced, inflammation is aggravated, and secondary injury of cardiac muscle is caused. On this basis, the intravascular nerve stimulation system that this application provided, accessible intervention mode with the blood vessel support implant in the spleen artery, provide the energy through external supersound, nanometer piezoelectric layer 2 converts ultrasonic energy into the electric energy, direct stimulation spleen nerve, activation spleen cholinergic anti-inflammatory pathway alleviates the inflammation state of coronary heart disease, avoids leaving behind the atheroma ulcer, prevents that the lumen from blocking from causing ischemic lesion, alleviates the ischemia reperfusion injury after percutaneous coronary intervention treatment simultaneously.
Inflammatory diseases such as systemic inflammatory response syndrome, sepsis, septic shock, autoimmune diseases or acute respiratory distress syndrome, arthritis, inflammatory bowel disease, etc., can inhibit the progression of the disease by being effectively anti-inflammatory. Such diseases may also be chronically stimulated for long periods of time using the present application to control inflammation.
The device can also be used for stimulating the peripheral nerves of the target blood vessel, promoting the contraction and relaxation functions of the target blood vessel and promoting the steady state recovery due to the imbalance of the steady state of the heart, the lung, the liver, the kidney, the intestinal tract, the muscle and other parts caused by the reconstruction of the blood vessel. Non-drug treatment of chronic pain, cerebral ischemia, dystonia, tremor, multiple sclerosis, parkinson's disease, neuropsychiatric diseases can also be performed using the device of the present application for spinal nerve stimulation to prevent and treat disease progression. In addition, hypertension, angina treatment, recurrent supraventricular tachycardia, atrial tachycardia and the like show higher sympathetic tone, and arterial sinus stimulation is carried out by the application, so that vagus nerve tone is increased, and poor progress of diseases is improved.
The treatment regimens described herein may be performed before or after the primary treatment modality to allow sufficient time to modulate local and systemic inflammatory mediators, cytokines, and cholinergic levels to achieve optimal clinical efficacy and restore immune homeostasis.
In the description of the present application, it is to be understood that the forward direction of "X" in the drawings represents the right direction, and correspondingly, the reverse direction of "X" represents the left direction; the forward direction of "Y" represents forward, and correspondingly, the reverse direction of "Y" represents rearward; the forward direction of "Z" represents the upward direction, and correspondingly, the reverse direction of "Z" represents the downward direction, and the directions or positional relationships indicated by the terms "X", "Y", "Z", etc. are based on the directions or positional relationships shown in the drawings of the specification, and are only for convenience of describing and simplifying the description, but do not indicate or imply that the device or element referred to must have a particular direction, be constructed and operated in a particular direction, and thus should not be construed as limiting the present application. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
In the description of the present application, it should be noted that the terms "upper", "lower", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only for convenience in describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present application. Unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
It is noted that, in the present application, relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above description is merely exemplary of the present application and is presented to enable those skilled in the art to understand and practice the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An intravascular stent, comprising:
a stent (1) implantable inside a target blood vessel;
a nano piezoelectric layer (2) which comprises a plurality of nano power generation units (20), wherein the nano power generation units (20) are arranged on the surface of the bracket (1) through a plurality of grooves (10) arranged on the surface of the bracket (1),
the nano power generation unit (20) can convert the received ultrasonic mechanical energy into electric energy for stimulating nerves in the wall of a target blood vessel.
2. An intravascular stent according to claim 1, wherein the nano-piezoelectric layer (2) is fully degradable in the human body.
3. An endovascular stent according to claim 2, wherein the nano-electricity generating unit (20) is a degradable polymer, and may be one or more of poly-L-lactide-co-glycolide, poly-3-hydroxybutyrate-co-3-hydroxyvalerate, polycaprolactone, and polyvinyl alcohol.
4. An intravascular stent according to claim 1, wherein the nano-piezoelectric layer (2) is provided with an outer protective coating (3) on the surface, and the stent (1) is a conductive stent (1).
5. Intravascular stent according to claim 4, wherein the outer protective coating (3) is fully degradable in the human body.
6. The intravascular stent according to claim 5, wherein the outer protective coating (3) is any one of methyl acrylate, polylactic acid, chondroitin sulfate and phosphorylcholine.
7. Intravascular stent according to claim 1, characterized in that the stent (1) is fully degradable in the human body.
8. Intravascular stent according to claim 7, characterized in that the stent (1) is a Zn-Cu alloy stent (1).
9. Intravascular stent according to claim 1, wherein the stent (1) is a hollow mesh structure.
10. An intravascular nerve stimulation system, comprising:
the intravascular stent of any one of claims 1-9;
an ultrasonic generating device (4) for ultrasonically vibrating the intravascular stent implanted inside a target vessel.
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| CN202111164818.3A CN113730055A (en) | 2021-09-30 | 2021-09-30 | Intravascular stent and intravascular nerve stimulation system |
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| CN202111164818.3A CN113730055A (en) | 2021-09-30 | 2021-09-30 | Intravascular stent and intravascular nerve stimulation system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115645610A (en) * | 2022-11-10 | 2023-01-31 | 深圳先进技术研究院 | Nerve conduit, preparation method and application thereof |
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