CN113711239A - 利用ii类mhc模型鉴别新抗原 - Google Patents

利用ii类mhc模型鉴别新抗原 Download PDF

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Publication number
CN113711239A
CN113711239A CN202080028058.0A CN202080028058A CN113711239A CN 113711239 A CN113711239 A CN 113711239A CN 202080028058 A CN202080028058 A CN 202080028058A CN 113711239 A CN113711239 A CN 113711239A
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allele
peptide
presentation
mhc
cells
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Chinese (zh)
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T·F·鲍彻
B·布里克-沙利文
J·巴斯比
高明德
M·J·戴维斯
L·E·扬
J·M·弗朗西斯
C·帕尔默
M·斯科伯恩
R·耶冷斯凯
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Seattle Project Co
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Millstone Biological Co
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/4201—Neoantigens
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CN202080028058.0A 2019-03-06 2020-03-06 利用ii类mhc模型鉴别新抗原 Pending CN113711239A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962814801P 2019-03-06 2019-03-06
US62/814,801 2019-03-06
US201962826822P 2019-03-29 2019-03-29
US62/826,822 2019-03-29
PCT/US2020/021508 WO2020181240A1 (en) 2019-03-06 2020-03-06 Identification of neoantigens with mhc class ii model

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CN113711239A true CN113711239A (zh) 2021-11-26

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US (1) US20220154281A1 (https=)
EP (1) EP3935071A4 (https=)
JP (2) JP7668742B2 (https=)
KR (1) KR20210137110A (https=)
CN (1) CN113711239A (https=)
AU (1) AU2020232844A1 (https=)
CA (1) CA3132041A1 (https=)
IL (1) IL286086A (https=)
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Cited By (7)

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CN113255690A (zh) * 2021-04-15 2021-08-13 南昌大学 一种基于轻量级卷积神经网络的复合绝缘子憎水性检测方法
CN114023387A (zh) * 2022-01-05 2022-02-08 山东建筑大学 一种基于卷积神经网络的细胞反卷积预测方法
CN114446385A (zh) * 2022-01-29 2022-05-06 杭州纽安津生物科技有限公司 Hla ii型分子与多肽的亲和力预测模型的获取方法及装置
CN115295084A (zh) * 2022-08-05 2022-11-04 南开大学 一种肿瘤新抗原免疫组库数据可视化分析方法和系统
CN116264103A (zh) * 2021-12-14 2023-06-16 深圳华大基因股份有限公司 构建机器学习模型的方法、系统及用途
CN120600110A (zh) * 2025-08-06 2025-09-05 上海交通大学医学院附属仁济医院 基于人工智能的多变病原t细胞表位精准筛选方法
EP4519675A4 (en) * 2022-05-03 2026-04-08 3T Biosciences Inc T-LYMPHOCYTE TARGET DISCOVERY

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CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
US11848073B2 (en) * 2019-04-03 2023-12-19 University Of Central Florida Research Foundation, Inc. Methods and system for efficient indexing for genetic genealogical discovery in large genotype databases
SG11202110956RA (en) 2019-04-05 2021-10-28 Rootpath Genomics Inc Compositions and methods for t-cell receptor gene assembly
US11644470B2 (en) * 2019-04-15 2023-05-09 Bioinformatics Solutions Inc. Systems and methods for de novo peptide sequencing using deep learning and spectrum pairs
US11727284B2 (en) * 2019-12-12 2023-08-15 Business Objects Software Ltd Interpretation of machine learning results using feature analysis
WO2022087380A1 (en) * 2020-10-23 2022-04-28 Rootpath Genomics, Inc. Compositions and methods for t-cell receptor identification
CN112910288B (zh) * 2020-12-08 2022-08-09 上海交通大学 一种基于逆变器散热器温度预测的过温预警方法
CN113160887B (zh) * 2021-04-23 2022-06-14 哈尔滨工业大学 一种融合了单细胞tcr测序数据的肿瘤新生抗原筛选方法
WO2023146978A2 (en) * 2022-01-26 2023-08-03 Memorial Sloan-Kettering Cancer Center Systems and methods for determining t-cell cross-reactivity between antigens
WO2023172633A1 (en) * 2022-03-08 2023-09-14 Avalo, Inc. System and method for genomic association
EP4570907A1 (en) * 2022-08-08 2025-06-18 Sapporo Medical University Method for selecting subject-derived neoantigen
AU2023321890A1 (en) * 2022-08-12 2025-02-27 Biontech Us Inc. Methods and systems for prediction of hla epitopes
EP4680270A1 (en) * 2023-03-13 2026-01-21 Seattle Project Corp. Epitope prediction via a learned genotype network across class ii mhc alleles
CN116469457B (zh) * 2023-06-14 2023-10-13 普瑞基准科技（北京）有限公司 Mhc与抗原多肽结合、呈递及免疫原性的预测模型训练方法和装置
CN117912568B (zh) * 2024-01-05 2024-08-06 中山大学 H9n2亚型禽流感毒株抗原性快速鉴别方法及装置
CN120089201B (zh) * 2025-04-30 2025-07-04 广东省农业科学院动物卫生研究所 一种基于深度学习的通用表位多肽筛选方法和系统

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WO2018195357A1 (en) * 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
CN109073637A (zh) * 2016-05-13 2018-12-21 生物技术Rna制药有限公司 用于预测蛋白质或蛋白质片段用于免疫治疗的有用性的方法
CN109145927A (zh) * 2017-06-16 2019-01-04 杭州海康威视数字技术股份有限公司 一种对形变图像的目标识别方法及装置

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CN107002038B (zh) * 2014-09-17 2021-10-15 约翰·霍普金斯大学 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法
RU2729116C2 (ru) * 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов

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CN109073637A (zh) * 2016-05-13 2018-12-21 生物技术Rna制药有限公司 用于预测蛋白质或蛋白质片段用于免疫治疗的有用性的方法
WO2018195357A1 (en) * 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
CN109145927A (zh) * 2017-06-16 2019-01-04 杭州海康威视数字技术股份有限公司 一种对形变图像的目标识别方法及装置

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113255690A (zh) * 2021-04-15 2021-08-13 南昌大学 一种基于轻量级卷积神经网络的复合绝缘子憎水性检测方法
CN113255690B (zh) * 2021-04-15 2022-04-12 南昌大学 一种基于轻量级卷积神经网络的复合绝缘子憎水性检测方法
CN116264103A (zh) * 2021-12-14 2023-06-16 深圳华大基因股份有限公司 构建机器学习模型的方法、系统及用途
CN114023387A (zh) * 2022-01-05 2022-02-08 山东建筑大学 一种基于卷积神经网络的细胞反卷积预测方法
CN114446385A (zh) * 2022-01-29 2022-05-06 杭州纽安津生物科技有限公司 Hla ii型分子与多肽的亲和力预测模型的获取方法及装置
EP4519675A4 (en) * 2022-05-03 2026-04-08 3T Biosciences Inc T-LYMPHOCYTE TARGET DISCOVERY
CN115295084A (zh) * 2022-08-05 2022-11-04 南开大学 一种肿瘤新抗原免疫组库数据可视化分析方法和系统
CN120600110A (zh) * 2025-08-06 2025-09-05 上海交通大学医学院附属仁济医院 基于人工智能的多变病原t细胞表位精准筛选方法

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JP2025114587A (ja) 2025-08-05
TW202100168A (zh) 2021-01-01
EP3935071A4 (en) 2022-12-21
JP2022524328A (ja) 2022-05-02
KR20210137110A (ko) 2021-11-17
US20220154281A1 (en) 2022-05-19
AU2020232844A1 (en) 2021-10-28
IL286086A (en) 2021-10-31
WO2020181240A8 (en) 2021-09-16
CA3132041A1 (en) 2020-09-10
WO2020181240A1 (en) 2020-09-10
EP3935071A1 (en) 2022-01-12
TWI894138B (zh) 2025-08-21
JP7668742B2 (ja) 2025-04-25

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