CN113693713A - Non-invasive tissue ablation electrode circuit - Google Patents
Non-invasive tissue ablation electrode circuit Download PDFInfo
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- CN113693713A CN113693713A CN202111046801.8A CN202111046801A CN113693713A CN 113693713 A CN113693713 A CN 113693713A CN 202111046801 A CN202111046801 A CN 202111046801A CN 113693713 A CN113693713 A CN 113693713A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00875—Resistance or impedance
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Abstract
The invention relates to a non-invasive tissue ablation electrode circuit, which comprises a substrate and a tissue ablation functional circuit, wherein the tissue ablation functional circuit is arranged on the substrate and comprises a positive electrode and a negative electrode, the positive electrode and the negative electrode are positioned on the same plane, and the positive electrode and the negative electrode are isolated from each other and are not communicated with each other. The invention has the advantages of realizing non-invasive treatment; the formed physical field is uniform, adjustable and controllable, and the treatment efficiency is high.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a non-invasive tissue ablation electrode circuit.
Background
The ablation electrode is used for transmitting the energy of the electric field, the magnetic field or the electromagnetic field to the local tissue of the human body, and the lesion tissue is damaged in situ by the energy of the physical factors, so that the method is a technical means generally adopted by the current tumor physical ablation technology. The hardware system of the tumor physical ablation technology generally comprises a physical energy source (generator), an ablation electrode, a connecting cable and the like, wherein the ablation electrode is contacted with a human body to finally form a complete treatment loop. The existing ablation electrode is mainly of a needle type structure, one or more pairs of needle type electrode arrays can be adopted during treatment according to different requirements of adopted physical energy, and the needle type electrodes are penetrated into the central area or the peripheral area of tumor tissues so as to form a required physical field in a tumor target area to realize treatment. However, since the needle-pricked electrode needs to prick the electrode body into the tissue of the human body, it is inevitable to cause needle-pricked damage to the tissue, especially, the tube wall damage of blood vessels, nerves, biliary tract or gastrointestinal tract, etc. passing through the tumor tissue, and the tumor tissue spreading and transferring along the needle channel, etc. are easily caused. In addition, the needle-punching electrode is usually a rigid structure, mainly through percutaneous puncture, laparotomy and other approaches to treatment, and can not realize noninvasive treatment through an endoscope or interventional means and other means by means of a natural cavity of a human body. Meanwhile, due to the special structural characteristics of the needle electrode, the physical field formed by the needle electrode is often unevenly distributed by taking the electrode as the center, certain difficulty exists in adjusting the range and the distribution characteristics of the physical field, physical energy is not easily evenly distributed in tissues, and residues are easily caused in tumor ablation treatment. Therefore, the needle electrode has limitations in use convenience, non-invasive treatment, wide application and ablation effectiveness, and cannot fully exert the advantages of the physical ablation technology.
Disclosure of Invention
The invention aims to solve the problems that the traditional needle type ablation electrode needs to be punctured into human tissues and has wound on human body; the structure is rigid, and noninvasive treatment can not be realized through the natural cavity of the human body; the formed physical field is not uniform, and is not easy to adjust and control, and the treatment efficiency is low.
The technical solution of the invention is as follows: the invention relates to a non-invasive tissue ablation electrode circuit, which is characterized in that: the non-invasive tissue ablation electrode circuit comprises a substrate and a tissue ablation functional circuit, wherein the tissue ablation functional circuit is arranged on the substrate and comprises a positive electrode and a negative electrode, the positive electrode and the negative electrode are positioned on the same plane, and the positive electrode and the negative electrode are isolated from each other and are not communicated with each other.
Furthermore, the tissue ablation function circuit is a polarity circuit in a square ring shape, a circular ring shape, a comb-tooth-shaped array shape or an I-shaped array shape.
Further, when the tissue ablation function circuit is square ring-shaped, the tissue ablation function circuit comprises a longitudinal circuit positioned at the center and a square circuit positioned at the periphery, wherein the longitudinal circuit and the square circuit are mutually positive and negative electrodes.
Further, when the tissue ablation function circuit is in a circular ring shape, the tissue ablation function circuit comprises a longitudinal circuit located at the center and an elliptical ring circuit located at the periphery, wherein the longitudinal circuit and the elliptical ring circuit are mutually positive and negative electrodes.
Furthermore, when the tissue ablation function circuit is in a comb-tooth-shaped array shape, the tissue ablation function circuit comprises a pair of comb-tooth-shaped circuits which are in central symmetry, the two comb-tooth-shaped circuits are arranged in a staggered mode, and the two comb-tooth-shaped circuits are positive and negative electrodes.
Furthermore, when the tissue ablation function circuit is in an I-shaped array shape, the tissue ablation function circuit comprises an I-shaped circuit positioned in the center and a linear circuit sequentially arranged around the I-shaped circuit, and the I-shaped circuit and the linear circuit are mutually positive and negative electrodes.
Furthermore, the electrode line width of the positive electrode and the negative electrode ranges from 0.1 mm to 4.0mm, the spacing ranges from 0.1 mm to 4.0mm, and the length ranges from 5 mm to 30 mm. Further settings and adjustments may be made to specific ablation target volumes.
Further, the non-invasive tissue ablation electrode circuit further comprises a detection circuit for measuring the temperature, pressure, electrochemistry or impedance of human tissue, and the detection circuit is positioned on the surface layer or the bottom layer of the substrate.
Further, the tissue ablation electrode circuit can simultaneously serve as an ablation function circuit and a detection circuit, and respectively play a role in different times.
Further, the substrate is one or more layers.
Furthermore, a pin circuit with a communication function is arranged on the substrate, and the pin circuit is communicated with the tissue ablation function and the detection circuit.
The invention provides a non-invasive tissue ablation electrode circuit. The conveying device is placed on the surface of the pathological change tissue, the tissue ablation functional circuit is in contact with the human tissue to form a treatment loop, the tissue ablation functional circuit transmits physical factor energy to the human tissue, a treatment field with certain geometric shape distribution is formed on the surface of the human tissue and in a certain depth, and the pathological change tissue is damaged by acting the physical factor energy in the treatment field on the human body, so that the purpose of treatment is achieved. The invention has the advantages of realizing non-invasive treatment; the formed physical field is uniform, adjustable and controllable, and the treatment efficiency is high.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a circuit diagram of a tissue ablation function according to a first embodiment of the present invention;
fig. 3 is a circuit diagram of a tissue ablation function of a second embodiment of the present invention;
FIG. 4 is a circuit diagram of a tissue ablation function of a third embodiment of the present invention;
fig. 5 is a circuit diagram of a tissue ablation function according to a fourth embodiment of the present invention.
The reference numerals are explained below:
1. a substrate; 2. a tissue ablation function circuit; 3. a column circuit; 4. a square circuit; 5. an elliptical loop circuit; 6. a comb-shaped circuit; 7. an I-shaped circuit; 8. a linear circuit; 9. a biological tissue.
Detailed Description
The general aspects of the invention will be described in further detail with reference to the following figures and specific examples:
referring to fig. 1, the structure of the embodiment of the present invention includes a substrate 1 and a tissue ablation functional circuit 2, wherein the substrate 1 is made of flexible or rigid material and can be formed by one or more layers of the substrate 1 which can perform different functions; the tissue ablation functional circuit 2 is made of conductive metal or non-metal materials according to certain geometric shape characteristics, and circuits with different functions can be simultaneously positioned on the substrate 1 in one layer or different layers; the circuits of different layers of the substrates 1 can be connected or mutually independent through via holes or other communication technologies; different substrates 1 are packaged into a whole by gluing or other means; the substrate 1 can be packaged and fixed on a delivery device or a surgical instrument to realize the ablation treatment of specific tissues through an endoscope, a laparoscope, an intervention or on the surface of a human body.
The tissue ablation functional circuit 2 which plays a role in ablation therapy generally comprises an anode (high voltage) and a cathode (grounding), two circuits with different polarities are positioned on the same layer (plane), and the anode and the cathode are mutually isolated and not communicated. The geometric parameters of the tissue ablation functional circuit 2 mainly include a line width W, a spacing S, a length L, etc., and according to the action principle, in order to ensure sufficient physical field distribution and avoid additional tissue damage, the electrode line width W is usually in the range of 0.1-4.0mm, the spacing S is usually in the range of 0.1-4.0mm, and the length L is usually in the range of 5-30mm, but is not limited to the above range. Further settings and adjustments may be made to specific ablation target volumes.
Besides the tissue ablation functional circuit 2 which is positioned on the surface of the ablation electrode and plays a role in treatment, a pin circuit which plays a role in communication is simultaneously contained in the bottom layer structure of the substrate 1, and the pin circuit and the tissue ablation functional circuit 2 can be positioned on the same plane or positioned on the lower layer. The pin circuit is connected by wires or cables or the like to a therapeutic source, including but not limited to a pulse generator, radio frequency generator, or the like, as is known in the art.
In addition, the functional circuit of the present invention may also include detection circuits or modules for measuring specific signals of human tissue temperature, pressure, electrochemistry, impedance, etc., and these detection circuits may be located on the surface layer or bottom layer of the circuit, and may be the same circuit as the therapeutic function or isolated from it. The detection circuits can be connected with the sensors or the control device through respective pins to acquire corresponding signals, and the circuits are all in the prior art, but the requirements of the overall preparation process of the ablation electrode are met in the preparation process.
The substrate 1 of the invention can be made of flexible or rigid materials and technical processes according to the actual requirements of the treatment scene and the delivery device, and the geometrical characteristics of the structure appearance, the thickness and the like can be optimized according to the circuit and the delivery device. The flexible material includes, but is not limited to, polymer materials such as Polyimide (PI), polyethylene terephthalate (PET), hydrogel, and silicone, and the rigid material includes, but is not limited to, organic glass, resin, and plastic.
The tissue ablation functional circuit 2 can be made of conductive metal, such as gold, silver, copper, platinum, stainless steel and the like, and can also be made of conductive nonmetal, such as special materials of graphene, conductive hydrogel, conductive macromolecules and the like. The circuit materials with different polarities and different functions can be the same or different.
The electrodes of different arrangements differ in volume, shape, major and minor diameters of the treatment area and the required physical energy intensity, depending on the principle of action and the shape of the electrode layout. The invention specifically lists 4 ablation electrode circuit layout methods with different geometrical characteristics, which are respectively in a square ring shape, a circular ring shape, a comb-tooth-shaped array shape and an I-shaped array shape.
In the actual use process, the tissue ablation functional circuit 2 is attached to the surface of the biological tissue 9, the energy transfer is realized by utilizing a loop formed between the electrode array and the tissue, and the in-situ damage to the tumor tissue is realized by utilizing the energy of the physical factor.
Referring to fig. 2, the basic configuration of the square ring circuit includes a longitudinal circuit 3 at the center and a square circuit 4 at the periphery, and the longitudinal circuit 3 and the square circuit 4 are positive and negative electrodes of each other. Taking an electric field as an example, the lower part of fig. 2 shows the distribution of the electric field from the surface (0mm) to the deep layer (4mm) of the biological tissue under the external voltage condition of 500V.
Referring to fig. 3, the basic configuration of the circular ring circuit includes a longitudinal circuit 3 located at the center and an elliptical ring circuit 5 located at the periphery, and the longitudinal circuit 3 and the elliptical ring circuit 5 are positive and negative electrodes of each other. Taking an electric field as an example, the lower part of fig. 3 shows the distribution of the electric field from the surface (0mm) to the deep layer (4mm) of the biological tissue under the external voltage condition of 500V.
Referring to fig. 4, the basic configuration of the comb-shaped circuit includes a pair of comb-shaped circuits 6 in central symmetry, and the two comb-shaped circuits 6 are arranged in a staggered manner and are positive and negative. Taking an electric field as an example, the lower part of fig. 4 shows the distribution of the electric field from the surface (0mm) to the deep layer (4mm) of the biological tissue under the external voltage condition of 500V.
Referring to fig. 5, the basic configuration of the i-shaped array circuit includes an i-shaped circuit 7 located at the center, and four linear circuits 8 sequentially arranged around the i-shaped circuit 7, wherein the i-shaped circuit 7 and the four linear circuits 8 are positive and negative electrodes. Taking an electric field as an example, the lower part of fig. 5 shows the distribution of the electric field from the surface (0mm) to the deep layer (4mm) of the biological tissue under the external voltage condition of 500V.
The present invention and the technical contents not specifically described in the above embodiments are the same as the prior art.
The above embodiments are only specific embodiments disclosed in the present invention, but the scope of the present invention is not limited thereto, and the scope of the present invention disclosed in the present invention should be subject to the scope of the claims.
Claims (10)
1. A non-invasive tissue ablation electrode circuit, comprising: the non-invasive tissue ablation electrode circuit comprises a substrate and a tissue ablation functional circuit, wherein the tissue ablation functional circuit is arranged on the substrate and comprises a positive electrode and a negative electrode, the positive electrode and the negative electrode are positioned on the same plane, and the positive electrode and the negative electrode are mutually isolated and not communicated with each other.
2. The non-invasive tissue ablation electrode circuit of claim 1, wherein: the tissue ablation functional circuit is a square ring-shaped, circular ring-shaped, comb-tooth-shaped array-shaped or I-shaped array-shaped polar circuit.
3. The non-invasive tissue ablation electrode circuit of claim 2, wherein: when the tissue ablation functional circuit is in a square ring shape, the tissue ablation functional circuit comprises a longitudinal circuit positioned at the center and a square circuit positioned at the periphery, wherein the longitudinal circuit and the square circuit are mutually a positive electrode and a negative electrode.
4. The non-invasive tissue ablation electrode circuit of claim 2, wherein: when the tissue ablation functional circuit is in a circular ring shape, the tissue ablation functional circuit comprises a longitudinal circuit positioned at the center and an elliptical ring circuit positioned at the periphery, wherein the longitudinal circuit and the elliptical ring circuit are mutually positive and negative electrodes.
5. The non-invasive tissue ablation electrode circuit of claim 2, wherein: when the tissue ablation functional circuit is in a comb-tooth array shape, the tissue ablation functional circuit comprises a pair of comb-tooth circuits which are centrosymmetric, and the two comb-tooth circuits are arranged in a staggered mode and are mutually positive and negative electrodes.
6. The non-invasive tissue ablation electrode circuit of claim 2, wherein: when the tissue ablation functional circuit is in an I-shaped array shape, the tissue ablation functional circuit comprises an I-shaped circuit located in the center and linear circuits sequentially arranged around the I-shaped circuit, and the I-shaped circuit and the linear circuits are positive and negative electrodes.
7. The non-invasive tissue ablation electrode circuit according to any one of claims 1 to 6, wherein: the electrode line width range of the positive electrode and the negative electrode is 0.1-4.0mm, the interval range is 0.1-4.0mm, and the length range is 5-30 mm.
8. The non-invasive tissue ablation electrode circuit of claim 7, wherein: the non-invasive tissue ablation electrode circuit further comprises a detection circuit for measuring the temperature, pressure, electrochemistry or impedance of human tissue, and the detection circuit is positioned on the surface layer or the bottom layer of the substrate.
9. The non-invasive tissue ablation electrode circuit of claim 8, wherein: the substrate is one or more layers.
10. The non-invasive tissue ablation electrode circuit of claim 9, wherein: and the substrate is also provided with a pin circuit with a communication function, and the pin circuit is communicated with the tissue ablation function circuit and the detection circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111046801.8A CN113693713A (en) | 2021-09-08 | 2021-09-08 | Non-invasive tissue ablation electrode circuit |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111046801.8A CN113693713A (en) | 2021-09-08 | 2021-09-08 | Non-invasive tissue ablation electrode circuit |
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| CN113693713A true CN113693713A (en) | 2021-11-26 |
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Citations (7)
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|---|---|---|---|---|
| US20010031961A1 (en) * | 2000-04-27 | 2001-10-18 | Hooven Michael D. | Method for transmural ablation |
| CN103202727A (en) * | 2012-01-12 | 2013-07-17 | 通用电气公司 | Non-invasive arrhythmia treatment system |
| US20130226269A1 (en) * | 2010-10-17 | 2013-08-29 | Syneron Medical Ltd | Disposable patch for personal aesthetic skin treatment |
| CN107205772A (en) * | 2014-12-15 | 2017-09-26 | 麦德托尼克消融前沿有限公司 | timing energy delivery |
| WO2019042111A1 (en) * | 2017-08-29 | 2019-03-07 | 苏世宽 | Non-invasive radio-frequency ablation system |
| CN112022339A (en) * | 2020-08-20 | 2020-12-04 | 华东理工大学 | Non-invasive electrode capable of adjusting area and depth and used for delivering electric pulses and application method |
| WO2021105903A1 (en) * | 2019-11-26 | 2021-06-03 | St. Jude Medical, Cardiology Division, Inc. | Ablation catheter tip with flexible electronic circuitry |
-
2021
- 2021-09-08 CN CN202111046801.8A patent/CN113693713A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010031961A1 (en) * | 2000-04-27 | 2001-10-18 | Hooven Michael D. | Method for transmural ablation |
| US20130226269A1 (en) * | 2010-10-17 | 2013-08-29 | Syneron Medical Ltd | Disposable patch for personal aesthetic skin treatment |
| CN103202727A (en) * | 2012-01-12 | 2013-07-17 | 通用电气公司 | Non-invasive arrhythmia treatment system |
| CN107205772A (en) * | 2014-12-15 | 2017-09-26 | 麦德托尼克消融前沿有限公司 | timing energy delivery |
| WO2019042111A1 (en) * | 2017-08-29 | 2019-03-07 | 苏世宽 | Non-invasive radio-frequency ablation system |
| WO2021105903A1 (en) * | 2019-11-26 | 2021-06-03 | St. Jude Medical, Cardiology Division, Inc. | Ablation catheter tip with flexible electronic circuitry |
| CN112022339A (en) * | 2020-08-20 | 2020-12-04 | 华东理工大学 | Non-invasive electrode capable of adjusting area and depth and used for delivering electric pulses and application method |
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