CN1136888C

CN1136888C - Medicine for treating hyperosteogeny and protrusion of lumber intervertebral disc and its preparation

Info

Publication number: CN1136888C
Application number: CNB011135972A
Authority: CN
Inventors: 陈志友
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-05-09
Filing date: 2001-05-09
Publication date: 2004-02-04
Anticipated expiration: 2021-05-09
Also published as: CN1322553A

Abstract

The present invention discloses a novel medicine for treating hyperosteogeny and protrusion of lumber intervertebral disc, which is prepared from raw materials of sesame oil, rosin, red lead, common monkshood mother root, centipede, combined spicebush root, cinnamon, nux vomica, frankincense, Chinese honeylocust fruit, scorpio, sanguis draconis and ground beetle. An ointment for external application is prepared by that the raw materials are respectively sliced, ground into powders, immersed in water, dewatered to extract original drug, proportioned and decocted according to the different characteristics of each drug. The present invention has the advantages of original formula and preparation, and obvious therapeutic effect.

Description

External used medicine of treatment hyperosteogeny and lumbar intervertebral disc prolapse and preparation method thereof

The present invention relates to a kind of medicine for the treatment of hyperosteogeny and lumbar intervertebral disc prolapse.Be the Chinese patent medicine of feedstock production specifically, the invention still further relates to the preparation method of this medicine with the Chinese herbal medicine.

Hyperosteogeny and lumbar intervertebral disc prolapse are serious disability's commonly encountered diseases, frequently-occurring diseases.Hyperosteogeny and lumbar intervertebral disc prolapse patient are nearly 100,015,000 in the world at present, and China is near 40,000,000, and the trend that increases is year by year arranged.

Both at home and abroad to the primary disease Drug therapy, run into following thorny problem at present:

1. hyperosteogeny and lumbar intervertebral disc prolapse are prolonged does not heal: I is a deficiency of both the liver and kidney, and medicine is tired hinders, spasm of muscles and vessels, and wind-cold damp pathogen gos deep into muscles and bones and causes the cloudy skeleton that stagnates of blood stasis, meridians, QI-blood circulation and be obstructed and form.II is plain body weakness, insufficiency of vital energy and blood, and space between skin and muscles is empty, attacks passages through which vital energy circulates in the wind-cold damp pathogen, and the retardance meridians cause qi and blood stagnation, and are obstructed through then.Since this because of, middle evening occurs man's prostatitis, prostate syndrome, endocrine disturbance, neurasthenia and quicken the concurrent of climacteric syndrome and increase the weight of.

2. ZHUANGGU GUANJIE WAN, bony spur tablet, Cortex Eucommiae Rhizoma Gastrodiae Pilulae, SHENJIN DAN need longly with the time, and the patient is difficult for reception.

3. chlorzoxazone, indometacin are obeyed infringement liver, kidney and hemocyte for a long time, make it to have produced hematopoietic disorder.

4. physiotherapy (traction method) makes the patient think busy, and is very bothersome longer with the course of treatment, and can not effect a radical cure.

5. operative treatment needs expensive economy, if be easy to generate lifelong paralysis or hinder the mistake work capacity at waist, though the Chinese patent medicine or the externally applied ointment of some treatment hyperosteogeny, lumbar intervertebral disc prolapse, but because effect is not fairly obvious, the patient still depends on some Western medicine, somedon, chlorzoxazone, sweet smell secrete etc., life-time service like this, make it to attack mutually, use more not all right and more not all right, increased the weight of the reorganization and the treatment difficulty of old complaint with old complaint.

The object of the present invention is to provide a kind of blood supply that can improve internal organs and limbs that has, improve and regulate the permeability of microcirculation adjusting blood capillary, infiltration cortex muscular tissue plays metabolism, circulation of qi promoting, removing blood stasis with potent drugs, blood stasis dispelling, analgesic effect.Blood vessel dilating improves hemorheological property, and blood viscosity lowering accelerates erythrocyte and platelet electrophoresis, the minimizing of the whole collection property of platelet.

There is resistive connection to form tissue to the cell regeneration that promotes blood cell, metabolic regulating action, it is synthetic to suppress fibroblast collagen, can enhance metabolism, some immune antibody be can obviously suppress, the hyperosteogeny of antiallergic action and the exterior-applied formulation of lumbar intervertebral disc prolapse strengthened.

Another object of the present invention provides the preparation method of a kind of this hyperosteogeny, lumbar intervertebral disc prolapse.

Solution of the present invention provides based on motherland's medical science hyperosteogeny, pathogenetic understanding of lumbar intervertebral disc prolapse and complication thereof and Therapeutic Principle, in conjunction with handed down from the older generations of the family experience, sum up and go out with reference to the clinical research achievement in surplus modern pharmacology and self 20 year, from hundreds of natural plants, filter out meticulously, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, drastically removing blood stasis and resolving static blood, unique curative effect of the reason of dispeling the wind, adopting the ancient method process of preparing Chinese medicine and modern pharmacology to combine develops, it at first combines treating different diseases with the same therapeutic principle with the human collateral channel system, Chinese medicine resuscitative prescription transdermal flux is opened the human collateral channel system, utilization is controlled the common pathomechanism of difficult disease " cold-phlegm " and the guiding drug of employing, make it have broken cold-phlegm, follow meridians and carry through affected area, the performance Chinese herbal treatment stasis of blood is long-pending, cold-phlegm, damp and hot, the blood stasis cell slowly necroses, thick dying, drain, to follow closely dead virocyte then through urine, perspiration, meridians and excreting, cause focus to dwindle or disappear, do not hinder the definite curative effect of healthy energy (no negative interaction) to reach treatment.

Medicine of the present invention is made by following component: (consumption is a weight portion) Oleum sesami 2000-2600 Colophonium 2800-3600 peach pellet (stir-fry) 380-475 Radix Aconiti 50-72 Scolopendra 40-60 Radix Linderae 50-72 Cortex Cinnamomi 50-72 Semen Strychni 50-72 Olibanum 110-132 Fructus Gleditsiae Abnormalis 30-50 Scorpio 50-72 Sanguis Draxonis 50-72 Eupolyphaga Seu Steleophaga 50-72

Formula optimization weight (part) ratio range of preparation medicine of the present invention is: Oleum sesami 2400-2600 Colophonium 2800-3100 peach pellet (stir-fry) 380-420 Radix Aconiti 50-60 Scolopendra 40-50 Radix Linderae 50-60 Cortex Cinnamomi 50-60 Semen Strychni 50-60 Olibanum 100-115 Fructus Gleditsiae Abnormalis 25-40 Scorpio 40-50 Sanguis Draxonis 50-60 Eupolyphaga Seu Steleophaga 50-60

The optimum weight of plaster of the present invention (part) proportioning is: Oleum sesami 2600 Colophonium 3100 peach pellets (stir-fry) 420 Radix Aconitis 60 Scolopendras 50 Radixs Linderae 60 Cortex Cinnamomi 60 Semen Strychni 60 Olibanums 115 Fructus Gleditsiae Abnormalis 40 Scorpio 50 exhaust 60 Eupolyphaga Seu Steleophagas 60

Above-mentioned each component is made medicine production method of the present invention is:

Secondly 1. at first with Semen Strychni (unhairing), cut the book sheet, Radix Aconiti, the Radix Linderae, Fructus Gleditsiae Abnormalis, Cortex Cinnamomi are cut the book sheet and placed in addition and add 338 parts of water purification in the container, soak 24 hours (stirring once in per 6 hours).

2. with Scolopendra, Scorpio (brackish water is not impregnated), Eupolyphaga Seu Steleophaga drying and crushing to 120 order fine powder; Again Sanguis Draxonis, Olibanum processing powder are broken into 120 order fineness, Scolopendra, Scorpio, Eupolyphaga Seu Steleophaga, Sanguis Draxonis, the Olibanum mixing pulverized is standby together.

3. Oleum sesami is put into container and endured to drip diffusing (about 110 ℃), go into former Semen Strychni, Radix Aconiti, the Radix Linderae, Fructus Gleditsiae Abnormalis, the Cortex Cinnamomi of soaking, its temperature is reduced to 80 ℃, stopped 30 minutes, and then heat up and to endure to 150 ℃, endure to 10 minutes, remove medicinal residues, filtering medicinal residues again, endure when dripping into pearl (150 ℃), add Colophonium again and dissolve turning off stove, blow slowly into Tao Dan, ceaselessly stir, this moment, temperature was about 110 ℃.

4. after above-mentioned whole powder components being pressed described mixed, slowly put at 100-110 ℃ and not stop stirring the companion, pour annealing poison (promptly third rare aldehyde material has zest or anaphylaxis) in the water then into, at this moment, can the obtain medical treatment externally applied medical ointment of hyperosteogeny, lumbar intervertebral disc prolapse.

The operation of tempering here is to adopt the step type cooling to temper, temperature is raised to 150 ℃ rapidly, thereafter segmentation drops to 80 ℃, tempering dead time is 30 minutes, and then being warming up to 150 ℃. this moment, important feature a: I of the present invention was the former medicine of water logging (1: 1), and what the maintenance crude drug in whole was not wasted extracts; II is that adding was character and the effect that keeps crude drug in whole after the part medical material ground to the powder, and plays bigger medicinal effect; III pours in the water, is for the poison of annealing, and reduces untoward reaction and anaphylaxis.

Another important feature of the present invention is to contain cardiotonic glycoside and glycoside unit and quinones synthetic compound in the plaster, parietin, dissolved blood protein matter, H-subst, content reaches 8-27%, can promote to invigorate blood circulation, metabolism, removing blood stasis with potent drugs knot, resistive connection form tissue and promote the regeneration of blood cell cell, quickens blood circulation, diaphoresis, can make local vascular dilation, blood circulation quickening, blood viscosity lowering, cell and platelet electrophoresis are accelerated, and the platelet aggregation minimizing relaxes muscle spasm pain.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1. easy to carry, cheap, treatment time is short, and is nontoxic to human body.

2. light disease person, external application separately (subsides), II, III phase or special heavy patient can return ball to unite use with nuclear, can obviously shorten nuclear and return the use amount of ball, SHENJIN DAN, bony spur pill, ZHUANGGU GUANJIE WAN, Cortex Eucommiae Rhizoma Gastrodiae Pilulae, therapeutic effect obviously increases, and can alleviate or eliminate its serious symptom and complication, the immunity of enhancing body significantly.

3. to hyperosteogeny, the lumbar intervertebral disc prolapse of needs operations, can remove the painful and expensive expense of operation from, use product of the present invention can partly replace SHENJIN DAN, ZHUANGGU GUANJIE WAN, bony spur tablet etc. or every day decocting for Chinese herbal medicine.

For showing the therapeutic effect of plaster of the present invention to hyperosteogeny and lumbar intervertebral disc prolapse, the present invention is through 240 routine clinical observations, and selects medical history, the state of an illness, age, its clinical data of sex.

Disease time: the longest 15 years, the shortest 1 year

Age of onset: minimum 38 years old, maximum 74 years old

The male: 135 examples, women's 105 examples, treatment situation during prescription on individual diagnosis: above-mentioned sick class is all through going to a doctor with Western medicine and other medicines poor effect.

Therapeutic outcome: hyperosteogeny, lumbar intervertebral disc prolapse, the shortlyest control that to accompany be 12 days, it is 32 days that Changzhi is treated, and cures 230 row, produce effects 4 examples, invalid 6 examples, total effective rate 97%.

Embodiment

Take by weighing raw material (gram) by following proportioning:

Oleum sesami 2000g Colophonium 2800g peach pellet (stir-fry) 380g Radix Aconiti 50g Scolopendra 40g Radix Linderae 50g Cortex Cinnamomi 50g Semen Strychni 50g Olibanum 110g Fructus Gleditsiae Abnormalis 30g Scorpio 50g Sanguis Draxonis 50g Eupolyphaga Seu Steleophaga 50g

Production method is as follows:

1. first with the Semen Strychni unhairing, shave, secondly with Radix Aconiti, the Radix Linderae, Fructus Gleditsiae Abnormalis, Cortex Cinnamomi, shave is placed in the container in addition again, adds water purification 338g, soaks 24 hours (stirring once in per 6 hours).

2. with Scolopendra, Scorpio (brackish water is not impregnated), Eupolyphaga Seu Steleophaga drying and crushing to 120 order fine powder, again Sanguis Draxonis, Olibanum processing powder are broken into 120 order fineness, Scolopendra, Scorpio, ground beetle, Sanguis Draxonis, the Olibanum mixing mixing pulverized is standby together.

3. Oleum sesami is put into container and endured to dripping and loose, former Semen Strychni, Radix Aconiti, the Radix Linderae, Fructus Gleditsiae Abnormalis, the Cortex Cinnamomi of soaking of people, its temperature drops to 80 ℃, stopped 30 minutes, and then be warming up to 150 ℃, endured the medicinal residues that go 10 minutes, filtering medicinal residues again, endure when dripping into pearl (150 ℃), add Colophonium more slowly and dissolve turning off stove, blow slowly into Tao Dan, ceaselessly stir, this moment, temperature was 110 ℃.

4. after above-mentioned whole powder components being pressed described mixed, at 110 ℃, slowly put into and do not stop stirring, pour the externally applied ointment medicine of annealing poison (promptly third rare aldehyde material has zest or anaphylaxis) can obtain medical treatment hyperosteogeny, lumbar intervertebral disc prolapse in the water then into.

Claims

1, a kind of external used medicine for the treatment of hyperosteogeny and lumbar intervertebral disc prolapse is characterized in that, is made by the following weight proportion raw material:

Oleum sesami 2000-2600 Colophonium 2800-3600 Plumbum preparatium 380-475 Radix Aconiti 50-72

Scolopendra 40-60 Radix Linderae 50-72 Cortex Cinnamomi 50-72 Semen Strychni 50-72

Olibanum 110-132 Fructus Gleditsiae Abnormalis 30-50 Scorpio 50-72 exhausts 50-72

Eupolyphaga Seu Steleophaga 50-72.

2, a kind of external used medicine for the treatment of hyperosteogeny and lumbar intervertebral disc prolapse is characterized in that, is made by the following weight proportion raw material:

Oleum sesami 2400-2600 Colophonium 2800-3100 Plumbum preparatium 380-420 Radix Aconiti 50-60

Scolopendra 40-50 Radix Linderae 50-60 Cortex Cinnamomi 50-60 Semen Strychni 50-60

Olibanum 100-115 Fructus Gleditsiae Abnormalis 25-40 Scorpio 40-50 exhausts 50-60

Eupolyphaga Seu Steleophaga 50-60.

3, the external used medicine of treatment hyperosteogeny according to claim 1 and lumbar intervertebral disc prolapse, wherein the weight proportion of each raw material is:

Oleum sesami 2600 Colophonium 3100 Plumbum preparatium 420 Radix Aconitis 60 Scolopendras 50 Radixs Linderae 60

Cortex Cinnamomi 60 Semen Strychni 60 Olibanums 115 Fructus Gleditsiae Abnormalis 40 Scorpio 50 exhaust 60 Eupolyphaga Seu Steleophagas 60.

4,, it is characterized in that described medicament is the plaster external preparation according to the external used medicine of claim 1,2 or 3 described treatment hyperosteogenys and lumbar intervertebral disc prolapse.

5, the preparation method of the external used medicine of treatment hyperosteogeny according to claim 4 and lumbar intervertebral disc prolapse, it is characterized in that getting earlier Semen Strychni, Radix Aconiti, the Radix Linderae, Fructus Gleditsiae Abnormalis, Cortex Cinnamomi and cut the book sheet, other places in the container, add 338 parts of water purification, soaked 24 hours, with Scolopendra, Scorpio, Eupolyphaga Seu Steleophaga, Sanguis Draxonis, Olibanum drying and crushing to 120 order fine powder, Scolopendra, Scorpio, Eupolyphaga Seu Steleophaga, Sanguis Draxonis, the Olibanum mixing pulverized is standby together, with the described on request ratio of above-mentioned medicine, divide successively under 110-150 ℃ of temperature, temper, make externally applied ointment.

6, the preparation method of the external used medicine of treatment hyperosteogeny according to claim 5 and lumbar intervertebral disc prolapse, the operation of tempering wherein is to adopt the cooling of the ladder of segmentation successively to temper, and temperature is raised to 150 ℃ rapidly, and segmentation is reduced to 80 ℃ then, stop 30 minutes, and then be warming up to 150 ℃.

7, the preparation method of the external used medicine of treatment hyperosteogeny according to claim 6 and lumbar intervertebral disc prolapse, wherein temper operation, the medicine of section is 110-150 ℃ of input, endure to 10 minutes remove slag, filtering, be cooled to 110 ℃ then the fine powder input that mixes stirred 10 minutes, pour in the water then.