CN113648290A - Superfine fiber membrane and preparation method and application thereof - Google Patents

Superfine fiber membrane and preparation method and application thereof Download PDF

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Publication number
CN113648290A
CN113648290A CN202110987215.7A CN202110987215A CN113648290A CN 113648290 A CN113648290 A CN 113648290A CN 202110987215 A CN202110987215 A CN 202110987215A CN 113648290 A CN113648290 A CN 113648290A
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Prior art keywords
fiber membrane
capsaicin
preparation
aliphatic polyester
spinning
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CN202110987215.7A
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Chinese (zh)
Inventor
金幼虹
徐佳
王雪
熊雨
叶青松
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Affiliated Stomatological Hospital Of Nanchang University (jiangxi Stomatological Hospital)
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Affiliated Stomatological Hospital Of Nanchang University (jiangxi Stomatological Hospital)
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Priority to CN202110987215.7A priority Critical patent/CN113648290A/en
Publication of CN113648290A publication Critical patent/CN113648290A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D1/00—Treatment of filament-forming or like material
    • D01D1/02—Preparation of spinning solutions
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
    • D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
    • D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
    • D01F8/10—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained by reactions only involving carbon-to-carbon unsaturated bonds as constituent
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
    • D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
    • D01F8/14—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyester as constituent
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4326—Condensation or reaction polymers
    • D04H1/435—Polyesters
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
    • D04H1/43838—Ultrafine fibres, e.g. microfibres

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Artificial Filaments (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides a superfine fiber membrane and a preparation method and application thereof, wherein the preparation method of the superfine fiber membrane comprises the following steps: adding an aliphatic polyester material, a hydrophilic material and capsaicin into a solvent, and stirring to obtain a spinning solution; and (3) placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain the superfine fiber membrane. The preparation method of the ultrafine fiber membrane uses the cosolvent, adopts the one-step dissolution method to blend and dissolve the aliphatic polyester material, the hydrophilic material and the capsaicin, and realizes the preparation of the capsaicin-loaded ultrafine fiber membrane by the electrostatic spinning method, and the membrane has larger specific surface area, has positive effect on the release of the medicament as a medicament carrier, and has potential application value in a plurality of fields.

Description

Superfine fiber membrane and preparation method and application thereof
Technical Field
The invention relates to the technical field of fiber membrane preparation, in particular to a superfine fiber membrane and a preparation method and application thereof.
Background
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the main active component of red pepper, and has various pharmacological activities, including analgesic, antioxidant, anti-apoptosis, antipruritic, antitumor, anti-inflammatory, and blood pressure regulating effects. In the beginning of 21 st century, Winston proposed that capsaicin be used for treating pain mainly through combination with TRPV1 receptors distributed on C-type primary afferent fibers to selectively destroy the C-type primary afferent fibers so as to achieve an analgesic effect, and experiments prove that local topical capsaicin cream has an effect of relieving diabetic neuropathy pain; research also shows that the antioxidant substance of capsaicin has antibacterial effect at the same time, and can be used as a safe and natural antibacterial product for limiting the growth of bacteria in the form of a biological membrane; the pharmacological properties of capsaicin provide possibility for wide clinical application and provide convenience for further research of scholars.
However, no technical solution for preparing a fiber membrane by using capsaicin is disclosed at present, and therefore, there is a need to provide a fiber membrane prepared by using capsaicin to further expand the application of capsaicin.
Disclosure of Invention
In view of the above, the present invention provides an ultrafine fibrous membrane, a method for preparing the same, and an application thereof, so as to solve or partially solve the technical problems in the prior art.
In a first aspect, the present invention provides a method for preparing an ultrafine fibrous membrane, comprising the steps of:
adding an aliphatic polyester material, a hydrophilic material and capsaicin into a solvent, and stirring to obtain a spinning solution;
and (3) placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain the superfine fiber membrane.
Preferably, in the preparation method of the ultrafine fiber membrane, the aliphatic polyester material includes at least one of polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer, and polycaprolactone.
Preferably, in the method for preparing the ultrafine fibrous membrane, the hydrophilic material comprises gelatin and/or polyvinylpyrrolidone.
Preferably, the solvent comprises trifluoroethanol and/or hexafluoroisopropanol.
Preferably, in the preparation method of the superfine fiber membrane, the volume ratio of the sum of the mass of the aliphatic polyester material and the hydrophilic material to the solvent is (5-40) g:100 ml;
the mass of the capsaicin is 0.00000001-20% of the sum of the mass of the aliphatic polyester material, the mass of the hydrophilic material and the mass of the capsaicin.
Preferably, the electrostatic spinning conditions of the preparation method of the superfine fiber membrane are as follows: the spinning voltage is 5-25 kV, and the receiving distance is 5-50 cm.
In a second aspect, the invention also provides an ultrafine fiber membrane prepared by the preparation method.
In a third aspect, the invention also provides the application of the superfine fiber membrane as a drug carrier.
Compared with the prior art, the superfine fiber membrane and the preparation method and the application thereof have the following beneficial effects:
(1) the preparation method of the ultrafine fiber membrane uses the cosolvent, adopts the one-step dissolution method to blend and dissolve the aliphatic polyester material, the hydrophilic material and the capsaicin, and prepares the capsaicin-loaded ultrafine fiber membrane through the electrostatic spinning method, thereby realizing the preparation of the capsaicin-loaded ultrafine fiber membrane, and the membrane has larger specific surface area, has positive effect on the release of the medicament as a medicament carrier, and has potential application value in a plurality of fields.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.
FIG. 1 is a photograph of an ultrafine fibrous membrane prepared in example 1 of the present invention;
FIG. 2 is a scanning electron microscope photograph of the microfiber membrane prepared in example 1 of the present invention;
FIG. 3 is a graph showing the adsorption-desorption isotherms of the microfiber membrane prepared in example 1 of the present invention;
FIG. 4 is a drug cumulative release profile of the ultrafine fibrous membrane prepared in example 1 of the present invention
Detailed Description
In the following, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding an aliphatic polyester material, a hydrophilic material and capsaicin into a solvent, and stirring to obtain a spinning solution;
and S2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain the superfine fiber membrane.
In some embodiments, the aliphatic polyester-based material comprises at least one of polylactic acid, polyglycolic acid, a polylactic-glycolic acid copolymer, polycaprolactone.
In some embodiments, the hydrophilic material comprises gelatin and/or polyvinylpyrrolidone.
In some embodiments, the solvent comprises trifluoroethanol and/or hexafluoroisopropanol.
In some embodiments, the volume ratio of the sum of the mass of the aliphatic polyester-based material and the mass of the hydrophilic material to the solvent is (5-40) g:100 ml;
the mass of the capsaicin is 0.00000001-20% of the sum of the mass of the aliphatic polyester material, the mass of the hydrophilic material and the mass of the capsaicin.
In some embodiments, the conditions of electrospinning are: the spinning voltage is 5-25 kV, and the receiving distance is 5-50 cm.
The ultrafine fibrous membranes of the examples of the present application were prepared by spinning using an electrospinning device. Specifically, the spinning solution is added into an injector, a needle head of the injector is connected with a positive electrode of a power supply, a conductive receiving device of electrostatic spinning equipment is grounded and is placed opposite to the needle head, the horizontal distance between the conductive receiving device and the needle head is 5-50 cm (namely, the receiving distance), the voltage is adjusted to be 5-25 kV, under a high-voltage electric field, the polymer solution can be ejected from the needle head and flies to the conductive receiving device, the solvent volatilizes in the flying process, the formed jet flow is solidified into superfine fibers, and the superfine fiber film can be received on the conductive receiving device.
The preparation method of the ultrafine fiber membrane uses the cosolvent, adopts the one-step dissolution method to blend and dissolve the aliphatic polyester material, the hydrophilic material and the capsaicin, and prepares the capsaicin-loaded ultrafine fiber membrane through the electrostatic spinning method, thereby realizing the preparation of the capsaicin-loaded ultrafine fiber membrane, and the membrane has larger specific surface area, has positive effect on the release of the medicament as a medicament carrier, and has potential application value in a plurality of fields.
Based on the same inventive concept, the invention also provides the application of the prepared superfine fiber membrane as a drug carrier.
The following further describes a method for preparing an ultrafine fibrous membrane according to the present application with specific examples.
Example 1
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding 0.45g of polylactic acid, 0.45g of gelatin and 0.0009g of capsaicin into 5ml of trifluoroethanol, and stirring at room temperature for 24 hours to obtain spinning solution;
s2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain an ultrafine fiber membrane; wherein the spinning voltage is 9kV, and the receiving distance is 15 cm.
Example 2
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding 0.45g of polylactic acid, 0.45g of polyvinylpyrrolidone (PVP) and 0.0009g of capsaicin into 5ml of trifluoroethanol, and stirring at room temperature for 24 hours to obtain a spinning solution;
s2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain an ultrafine fiber membrane; wherein the spinning voltage is 20kV, and the receiving distance is 15 cm.
Example 3
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding 0.45g of polylactic acid, 0.45g of gelatin and 0.0009g of capsaicin into 5ml of hexafluoroisopropanol, and stirring at room temperature for 24 hours to obtain spinning solution;
s2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain an ultrafine fiber membrane; wherein the spinning voltage is 20kV, and the receiving distance is 15 cm.
Example 4
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding 0.675g of polylactic acid, 0.225g of gelatin and 0.045g of capsaicin into 5ml of trifluoroethanol, and stirring at room temperature for 24 hours to obtain spinning solution;
s2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain an ultrafine fiber membrane; wherein the spinning voltage is 16kV, and the receiving distance is 15 cm.
Example 5
The embodiment of the application provides a preparation method of an ultrafine fiber membrane, which comprises the following steps:
s1, adding 0.225g of polylactic acid, 0.675g of gelatin and 0.0045g of capsaicin into 5ml of trifluoroethanol, and stirring at room temperature for 24 hours to obtain spinning solution;
s2, placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain an ultrafine fiber membrane; wherein the spinning voltage is 7.5kV, and the receiving distance is 15 cm.
Performance testing
A photograph of a sample of the ultrafine fibrous membrane prepared in example 1 is shown in FIG. 1.
Fig. 2 is a scanning electron microscope image of the ultrafine fibrous membrane prepared in example 1, and it can be clearly seen from fig. 2 that the membrane is composed of a large number of ultrafine fibers and the morphology of the fibers is relatively uniform at a magnification of 2000 times, confirming the fiber structure of the membrane.
The specific surface area of the ultrafine fiber membrane prepared in example 1 was tested by the following specific test method:
a certain amount of the microfibrous membrane prepared in example 1 was placed in a sample tube, degassed at 50 ℃ for 4 hours, and then the sample tube was placed in saturated liquid nitrogen, and the adsorption-desorption isotherm curve of the microfibrous membrane was measured, and the specific surface area of the microfibrous membrane sample was calculated by the BET mode of the instrument, and the results are shown in fig. 3. From FIG. 3, throughThe specific surface area of the ultrafine fiber membrane prepared in example 1 was calculated to be 0.2067m2The ultrafine fiber membranes prepared according to the present invention have a large specific surface area.
Drug release behavior of ultrafine fibrous membrane
PBS containing Tween 80 (cosolvent) was used as the release medium (wherein, VPBSAnd VTween 8099:1), then weighing a certain amount of the superfine fiber membrane prepared in example 1, soaking in 20mL of release medium, and placing in a constant temperature shaking table at 37 ℃. Sucking 1mL of the supernatant of the release medium at different time points, adding an equal volume of the release medium at the same time to maintain the volume of the release medium at 20mL all the time, preparing a standard sample, measuring the absorption intensity of each sample at 280nm of the experimental sample, drawing a standard curve, calculating the concentration of capsaicin in a system at each time point, and making an accumulated release curve of the capsaicin, wherein the result is shown in FIG. 4.
As can be seen from fig. 4, the cumulative amount of capsaicin released into the system increased significantly over the first 90 minutes, and then slowly over the next several hours, reaching 82.05% over the 8 hours.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. The preparation method of the superfine fiber membrane is characterized by comprising the following steps:
adding an aliphatic polyester material, a hydrophilic material and capsaicin into a solvent, and stirring to obtain a spinning solution;
and (3) placing the spinning solution in an injector of electrostatic spinning equipment, and performing electrostatic spinning to obtain the superfine fiber membrane.
2. The method of claim 1, wherein the aliphatic polyester-based material comprises at least one of polylactic acid, polyglycolic acid, a copolymer of polylactic acid and glycolic acid, and polycaprolactone.
3. The method of preparing the ultrafine fibrous membrane according to claim 1, wherein the hydrophilic material comprises gelatin and/or polyvinylpyrrolidone.
4. The method of preparing the ultrafine fibrous membrane according to claim 1, wherein the solvent comprises trifluoroethanol and/or hexafluoroisopropanol.
5. The method for preparing the ultrafine fibrous membrane according to claim 1, wherein the volume ratio of the sum of the masses of the aliphatic polyester-based material and the hydrophilic material to the solvent is (5-40) g:100 ml;
the mass of the capsaicin is 0.00000001-20% of the sum of the mass of the aliphatic polyester material, the mass of the hydrophilic material and the capsaicin.
6. The method for preparing the ultrafine fibrous membrane according to claim 1, wherein the conditions of electrospinning are: the spinning voltage is 5-25 kV, and the receiving distance is 5-50 cm.
7. An ultrafine fibrous membrane, characterized by being prepared by the preparation method according to any one of claims 1 to 6.
8. Use of the microfibrous membrane of claim 7 as a pharmaceutical carrier.
CN202110987215.7A 2021-08-26 2021-08-26 Superfine fiber membrane and preparation method and application thereof Pending CN113648290A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101417150A (en) * 2008-10-23 2009-04-29 吉林大学 The preparation method of aliphatic polyester-chitosan composite fiber tissue repair bracket
CN102242463A (en) * 2011-04-20 2011-11-16 东华大学 Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning
CN102552220A (en) * 2012-01-06 2012-07-11 天津大学 Method of preparing polymer electrospinning fiber and application in transdermal drug delivery patch
CN103948974A (en) * 2013-12-30 2014-07-30 北京化工大学 Drug-loading type guided tissue regeneration membrane and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101417150A (en) * 2008-10-23 2009-04-29 吉林大学 The preparation method of aliphatic polyester-chitosan composite fiber tissue repair bracket
CN102242463A (en) * 2011-04-20 2011-11-16 东华大学 Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning
CN102552220A (en) * 2012-01-06 2012-07-11 天津大学 Method of preparing polymer electrospinning fiber and application in transdermal drug delivery patch
CN103948974A (en) * 2013-12-30 2014-07-30 北京化工大学 Drug-loading type guided tissue regeneration membrane and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
史雁暇等: "聚乳酸／辣椒素复合载药薄膜的制备及药物释放", 《材料导报Ｂ：研究篇》 *

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Application publication date: 20211116

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