CN113648243A - Acne-removing and scar-inhibiting mask and preparation method thereof - Google Patents
Acne-removing and scar-inhibiting mask and preparation method thereof Download PDFInfo
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- CN113648243A CN113648243A CN202111133619.6A CN202111133619A CN113648243A CN 113648243 A CN113648243 A CN 113648243A CN 202111133619 A CN202111133619 A CN 202111133619A CN 113648243 A CN113648243 A CN 113648243A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/008—Supramolecular polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention relates to an acne-removing and scar-inhibiting mask and a preparation method thereof. The nano cellulose facial mask prepared by the invention is a dry solid film, is convenient to transport and store, does not need auxiliary agents such as preservatives and the like, and can be used only by soaking with purified water or cosmetic water before use. The facial mask has good air permeability, easy transdermal drug delivery, and obvious acne and scar removing effect. The product has simple preparation method and can realize mass production.
Description
Technical Field
The invention belongs to the field of functional masks and preparation thereof, and particularly relates to an acne-removing and scar-inhibiting mask and a preparation method thereof.
Background
Acne is usually caused by propionibacterium infection, excessive sebum secretion, strong androgen secretion, abnormal formation of lipid plugs in follicular keratosis, inflammation and the like. It is good for teenagers, also called as acne and comedo.
The scar is easily formed when the organism suffers from severe acne, and the scar is generated by self-repairing of the skin after the skin is injured and is formed by hyperplasia and accumulation of a large amount of collagen fibers. The tissue pathological characteristics and clinical characteristics are differentiated to be classified into superficial scars, atrophic scars, hypertrophic scars and keloids. The generation of scar has certain genetic susceptibility, can regulate the expression of key genes and inhibit the generation of scar. Antisense oligonucleotide technology is to use artificial preparation or organism to synthesize antisense DNA or antisense RNA segment of target sequence, which can be specifically complementary with target mRNA or DNA, to inhibit the transcription of the gene, prevent its expression and make its function lost. Selectively degrade the gene family containing the subsequence high homology and inhibit the expression thereof, thereby having the characteristics of high transfection efficiency, strong specificity, high activity and the like.
The facial mask is a short-term packaged skin care product, can realize multiple functions of moisturizing, cleaning, improving appearance and the like of skin, and can also realize treatment of skin diseases. The acne-removing and scar-inhibiting nanofiber composite facial mask has the advantages that a lot of products are designed for the anti-acne facial mask in the current market, research on scar repair after acne treatment is less, and the acne-removing and scar-inhibiting facial mask which is obvious in acne-removing and scar-inhibiting effect, rapid in acne removal, free of scar generation, safe and free of side effects is urgently needed to be developed aiming at the defects of the prior art.
Disclosure of Invention
The invention aims to solve the technical problem of providing an acne-removing and scar-inhibiting mask and a preparation method thereof, and overcoming the defect that the cicatricial hyperplasia in the prior art cannot be effectively repaired.
The acne-removing and scar-inhibiting mask comprises the components of gelatin, Cu-BTC/ASON nano materials and tretinoin.
The Cu-BTC/ASON nano material is obtained by self-assembling heat shock protein and a metal organic framework material Cu-BTC.
The invention discloses a preparation method of a acne-removing and scar-inhibiting mask, which comprises the following steps:
adding gelatin into a solvent, stirring for 8-12h, adding a Cu-BTC/ASON nano material and tretinoin to obtain a mixed solution, and performing electrostatic spinning to obtain the acne-removing and scar-inhibiting mask.
The preferred mode of the above preparation method is as follows:
the mass percentage concentration of the gelatin added into the solvent is 6-10%, wherein the solvent is hexafluoroisopropanol; the mass percentage of the Cu-BTC/ASON nano material in the mixed solution is 0.01-0.2%, and the mass percentage of the tretinoin is 0.001-0.1%.
The Cu-BTC/ASON nano material specifically comprises the following components: the heat shock protein HSP47 antisense oligonucleotide 5'-CATGGCTGGGAGGTG-3' is subjected to phosphorylation treatment and is mixed with a Cu-BTC solution of a metal organic framework material with copper as a center, and the phosphate group of the nucleotide and a central copper atom are subjected to self-assembly to obtain the Cu-BTC/ASON nano material.
The molar ratio of the heat shock protein HSP47 antisense oligonucleotide to the Cu-BTC metal organic framework material with the copper as the center is 104：2-105：2。
The Cu-BTC metal organic framework material with copper as the center is specifically as follows: adding an organic ligand and a surfactant into the copper ion solution, carrying out water bath at 20-60 ℃, uniformly stirring, reacting for 5-20 minutes, standing at room temperature, centrifuging at 10000-.
The mass percentage concentration of the copper ion solution is 5-15%, and the copper ion solution is copper chloride, copper nitrate or copper acetate solution; the organic ligand is trimesic acid; the surface active agent is polyvinylpyrrolidone PVP, and the molecular weight is 3-5 ten thousand; the mass percentage concentration of the added organic ligand is 2-15%.
The self-assembly specifically comprises: the antisense oligonucleotide and Cu-BTC solution are mixed evenly, incubated for 24h at a constant temperature of 25 ℃, and added with sodium chloride to ensure that the concentration of the solution is 0.2-0.8M, so as to eliminate electrostatic repulsion. Finally 10000-.
The electrostatic spinning process parameters are as follows: the voltage is 10-20KV, the solution flow rate is 10-50 μ L/min, the receiving distance is 15-25cm, and the temperature is 25 deg.C.
The facial mask obtained by the invention can be used only by using purified water or cosmetic water for soaking.
Advantageous effects
The Cu-BTC prepared by the invention has good anti-inflammatory and anti-inflammatory effects, can promote wound healing and inhibit inflammatory reaction, is easy to modify as a nano-carrier in a porous structure, is good in biocompatibility and easy for transdermal delivery, and is a nano-composite material obtained by self-organizing with ASON. The prepared nano cellulose facial mask is a dry solid film, is convenient to transport and store, does not need to add auxiliary agents such as preservatives and the like, and can be used only by soaking with purified water or cosmetic water before use. The facial mask has good air permeability, easy transdermal drug delivery, and obvious acne and scar removing effect. The product has simple preparation method and can realize mass production.
The acne-removing and scar-inhibiting nanofiber composite mask has the advantages of obvious acne-removing and scar-inhibiting effects, quick acne removal, no scar generation, safety and no side effect.
Drawings
FIG. 1 is a SEM image of example 1.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
The molecular weight of polyvinylpyrrolidone (PVP) is 3-5 ten thousand
Example 1
1) Adding 10 mass percent of trimesic acid organic ligand into 5 mass percent of copper nitrate solution, simultaneously adding 10 mass percent of surfactant polyvinylpyrrolidone (PVP) to control the particle size, carrying out water bath at 60 ℃, uniformly stirring, reacting for 20 minutes, standing at room temperature, centrifuging at 20000r/min, washing for 3 times by deionized water, and preparing the metal organic framework material Cu-BTC taking copper as the center.
2) Phosphorylating antisense oligonucleotide 5'-CATGGCTGGGAGGTG-3' of HSP47 as heat shock protein, and mixing with the above Cu-BTC at a molar ratio of 104: 2, mixing evenly, incubating for 24h at a constant temperature of 25 ℃, adding sodium chloride to ensure that the concentration of the solution is 0.5M, and eliminating electrostatic repulsion. And finally, centrifuging at 20000r/min, washing for 3 times by using deionized water, and carrying out self-assembly on the phosphate group of the nucleotide and the central copper atom to obtain the Cu-BTC/ASON nano material.
3) Adding gelatin into hexafluoroisopropanol, wherein the mass percent of the gelatin is 8%, magnetically stirring for 8 hours at 25 ℃ to obtain a clear solution, and adding the Cu-BTC/ASON nano material with the mass percent of 0.1% and the tretinoin with the mass percent of 0.01% to obtain a mixed solution.
4) Fully and uniformly stirring the obtained mixed solution, and carrying out electrostatic spinning, wherein the spinning conditions are as follows: the voltage is 12kv, the solution flow is 10 mul/min, the receiving distance is 15cm, the temperature is 25 ℃, and the nano-fiber mask is obtained by spinning for one hour.
Example 2
1) Adding 10 mass percent of trimesic acid organic ligand into 10 mass percent of copper nitrate solution, simultaneously adding 15 mass percent of surfactant polyvinylpyrrolidone (PVP) to control the particle size, carrying out water bath at 25 ℃, uniformly stirring to react for 5 minutes, standing at room temperature, centrifuging at 20000r/min, and washing for 3 times by deionized water to prepare the metal organic framework material Cu-BTC taking copper as the center.
2) Phosphorylating heat shock protein HSP47 antisense oligonucleotide 5'-CATGGCTGGGAGGTG-3', mixing with the above Cu-BTC solution, wherein the molar ratio of antisense oligonucleotide to Cu-BTC is 105: 2, mixing evenly, incubating for 24h at a constant temperature of 25 ℃, adding sodium chloride to ensure that the concentration of the solution is 0.2M, and eliminating electrostatic repulsion. And finally, centrifuging at 20000r/min, washing for 3 times by using deionized water, and carrying out self-assembly on the phosphate group of the nucleotide and the central copper atom to obtain the Cu-BTC/ASON nano material.
3) Adding gelatin into hexafluoroisopropanol, wherein the mass percentage of the gelatin is 10%, magnetically stirring for 8 hours at 25 ℃ to obtain a clear solution, and adding the 0.2% Cu-BTC/ASON nano material and 0.005% tretinoin to obtain a mixed solution.
4) Fully and uniformly stirring the obtained mixed solution, and carrying out electrostatic spinning, wherein the spinning conditions are as follows: the voltage was 20kv, the solution flow rate was 50. mu.L/min, the receiving distance was 20cm, and the temperature was 25 ℃. Spinning for one hour to obtain the nanofiber mask.
Example 3
1) Adding 15 mass percent of trimesic acid organic ligand into 8 mass percent of copper nitrate solution, simultaneously adding 10 mass percent of surfactant polyvinylpyrrolidone (PVP) to control the particle size, carrying out water bath at 50 ℃, uniformly stirring to react for 10 minutes, standing at room temperature, centrifuging at 15000r/min, and washing for 3 times by deionized water to prepare the metal organic framework material Cu-BTC taking copper as the center.
2) Heat shock protein HSP47 antisense oligonucleotide 5'-CATGGCTGGGAGGTG-3' was phosphorylated, and mixed with the above Cu-BTC solution (molar ratio: 10000: 2) mixing, incubating at 25 deg.C for 24 hr, adding sodium chloride to make the concentration of the solution be 0.8M, and eliminating electrostatic repulsion. And finally, centrifuging at 15000r/min, washing for 3 times by using deionized water, and carrying out self-assembly on the phosphate group of the nucleotide and the central copper atom to obtain the Cu-BTC/ASON nano material.
3) Adding gelatin into hexafluoroisopropanol, wherein the mass percentage of the gelatin is 9%, magnetically stirring for 8 hours at 25 ℃ to obtain a clear solution, and adding the 0.15% Cu-BTC/ASON nano material and 0.05% tretinoin to obtain a mixed solution.
4) Fully and uniformly stirring the obtained mixed solution, and carrying out electrostatic spinning, wherein the spinning conditions are as follows: the voltage was 18kv, the solution flow was 20. mu.L/min, the receiving distance was 20cm, and the temperature was 25 ℃. Spinning for one hour to obtain the nanofiber mask.
Example 4
1) Adding 15 mass percent of trimesic acid organic ligand into 8 mass percent of copper nitrate solution, simultaneously adding 10 mass percent of surfactant polyvinylpyrrolidone (PVP) to control the particle size, carrying out water bath at 30 ℃, uniformly stirring, reacting for 20 minutes, standing at room temperature, centrifuging at 10000r/min, and washing for 3 times by deionized water to prepare the copper-centered metal organic framework material Cu-BTC.
2) Adding gelatin into hexafluoroisopropanol, wherein the mass percentage of the gelatin is 9%, magnetically stirring for 8h at 25 ℃ to obtain a clear solution, and adding the heat shock protein HSP47 antisense oligonucleotide with the mass fraction of 0.15% and the Cu-BTC mixed solution with the molar ratio of 104: 2 and 0.05% tretinoin to give a mixed solution.
3) Fully and uniformly stirring the obtained mixed solution, and carrying out electrostatic spinning, wherein the spinning conditions are as follows: the voltage was 18kv, the solution flow was 20. mu.L/min, the receiving distance was 20cm, and the temperature was 25 ℃. Spinning for one hour to obtain the nanofiber mask.
Claims (9)
1. The acne-removing and scar-inhibiting mask is characterized in that the mask components comprise gelatin, Cu-BTC/ASON nano materials and tretinoin.
2. The mask of claim 1, wherein the Cu-BTC/ASON nanomaterial is obtained by self-assembly of heat shock proteins and metal organic framework materials Cu-BTC.
3. A preparation method of the acne-removing and scar-inhibiting mask comprises the following steps:
adding gelatin into a solvent, stirring, adding a Cu-BTC/ASON nano material and tretinoin to obtain a mixed solution, and performing electrostatic spinning to obtain the acne-removing and scar-inhibiting mask.
4. The production method according to claim 3, wherein the solvent is hexafluoroisopropanol; the mass percentage concentration of the gelatin added into the solvent is 6-10%; the mass percentage of the Cu-BTC/ASON nano material in the mixed solution is 0.01-0.2%, and the mass percentage of the tretinoin is 0.001-0.1%.
5. The preparation method according to claim 3, wherein the Cu-BTC/ASON nano-material is specifically: the heat shock protein HSP47 antisense oligonucleotide 5'-CATGGCTGGGAGGTG-3' is subjected to phosphorylation treatment, and is mixed with a Cu-BTC solution of a metal organic framework material with copper as a center for self-assembly to obtain the Cu-BTC/ASON nano material.
6. The method of claim 5, wherein the molar ratio of the heat shock protein HSP47 antisense oligonucleotide to the copper-centered metal-organic framework material Cu-BTC is 104：2～105：2。
7. The preparation method according to claim 5, wherein the copper-centered metal-organic framework material Cu-BTC is specifically: and adding an organic ligand and a surfactant into the copper ion solution to prepare the metal organic framework material Cu-BTC taking copper as the center.
8. The preparation method according to claim 7, wherein the mass percentage concentration of the copper ion solution is 5-15%, and the copper ion solution is a copper chloride, copper nitrate or copper acetate solution; the organic ligand is trimesic acid; the surface active agent is polyvinylpyrrolidone PVP; the mass percentage concentration of the added organic ligand is 2-15%.
9. The preparation method according to claim 3, wherein the electrostatic spinning process parameters are as follows: the voltage is 10-20KV, the solution flow rate is 10-50 μ L/min, the receiving distance is 15-25cm, and the temperature is 25 deg.C.
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| CN202111133619.6A CN113648243A (en) | 2021-09-26 | 2021-09-26 | Acne-removing and scar-inhibiting mask and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107022899A (en) * | 2017-04-28 | 2017-08-08 | 东华大学 | Metal organic frame/polymer nanofiber composite film material and preparation method thereof |
| CN111317826A (en) * | 2020-03-19 | 2020-06-23 | 上海交通大学 | Nucleic acid composite nano-drug constructed based on metal ion coordination self-assembly and preparation method and application thereof |
| CN112220959A (en) * | 2020-10-29 | 2021-01-15 | 华南理工大学 | Copper-based MOF hydrogel functionalized antibacterial film and preparation method and application thereof |
| CN113106635A (en) * | 2021-03-15 | 2021-07-13 | 广东金发科技有限公司 | Electrostatic spinning nanofiber non-woven fabric and preparation method and application thereof |
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2021
- 2021-09-26 CN CN202111133619.6A patent/CN113648243A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107022899A (en) * | 2017-04-28 | 2017-08-08 | 东华大学 | Metal organic frame/polymer nanofiber composite film material and preparation method thereof |
| CN111317826A (en) * | 2020-03-19 | 2020-06-23 | 上海交通大学 | Nucleic acid composite nano-drug constructed based on metal ion coordination self-assembly and preparation method and application thereof |
| CN112220959A (en) * | 2020-10-29 | 2021-01-15 | 华南理工大学 | Copper-based MOF hydrogel functionalized antibacterial film and preparation method and application thereof |
| CN113106635A (en) * | 2021-03-15 | 2021-07-13 | 广东金发科技有限公司 | Electrostatic spinning nanofiber non-woven fabric and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王佐林等: "HSP47和TGFβ1在大鼠皮肤瘢痕形成中的作用" * |
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