CN113640507B - Portable fluorescence immunoassay quantitative analyzer - Google Patents

Portable fluorescence immunoassay quantitative analyzer Download PDF

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Publication number
CN113640507B
CN113640507B CN202110799569.9A CN202110799569A CN113640507B CN 113640507 B CN113640507 B CN 113640507B CN 202110799569 A CN202110799569 A CN 202110799569A CN 113640507 B CN113640507 B CN 113640507B
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wall
auxiliary
fixed
box
side wall
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CN113640507A (en
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崔智龙
何万圆
王洛
贾银梁
张林帅
赵健凯
林宇鹏
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Anhui Tongkang Medical Technology Co ltd
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Anhui Tongkang Medical Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Hematology (AREA)
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  • Urology & Nephrology (AREA)
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  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention discloses a portable fluorescence immunity quantitative analyzer, which comprises an organism, wherein a slot is formed in the side wall of the organism, a counterweight plate is fixed at the upper end of the organism, two main spray boxes are arranged at the upper part of the organism, two auxiliary spray boxes are arranged at the lower part of the organism, a main spray mechanism and an auxiliary spray mechanism are respectively arranged on the main spray box and the auxiliary spray boxes, an airflow groove is formed in the side wall of the counterweight plate, and a landing sensing mechanism is arranged inside the airflow groove. Has the advantages that: according to the invention, the main protective bag is arranged, so that the machine body can be effectively buffered and protected when the machine body falls carelessly, the machine body is prevented from being damaged due to falling and impact, the service life of the machine body is prolonged, the insecurity caused by portability is effectively overcome, the use safety of equipment is ensured, and the integral performance is further improved.

Description

Portable fluorescence immunoassay quantitative analyzer
Technical Field
The invention relates to the technical field of fluorescence detection, in particular to a portable fluorescence immunoassay quantitative analyzer.
Background
The fluorescence immunoassay analyzer is an immunofluorescence detection method designed on the basis of an immunofluorescence technology, a chromatography technology and a laser induction technology, and the traditional fluorescence immunoassay analyzer is large in size, inconvenient to carry and operate outdoors, and has certain defects in use;
many equipment reform transform original machine into the integrated level height, whole volume is less, portable analyzer convenient to it is handheld, thereby obtain extensive use, however, portable equipment that the integrated level was heightened often receives to strike just can impaired inefficacy, and because the portable characteristic of equipment, be in an unstable state during the equipment use, very easily drop and then receive to strike impaired because of the manual operation, current equipment can't realize the self-protection, lead to equipment damage probability high, the life of equipment is shorter.
Disclosure of Invention
The invention aims to solve the problem of poor safety in the prior art, and provides a portable fluorescence immunoassay quantitative analyzer.
In order to achieve the purpose, the invention adopts the following technical scheme: the utility model provides a portable fluorescence immunity quantitative analyzer, includes the organism, the slot has been seted up to the lateral wall of organism, the upper end of organism is fixed with the counterweight plate, the upper portion of organism is equipped with two main spray tanks, the lower part of organism is equipped with two vice spray tanks, be equipped with main injection mechanism and vice mechanism of spouting on main spray tank and the vice spray tank respectively, the air current groove has been seted up to the lateral wall of counterweight plate, the inside of air current groove is equipped with descending perception mechanism, the power connection chamber and the trigger chamber have been seted up to the lateral wall of counterweight plate, power connection chamber and trigger intracavity part are equipped with respectively and connect power mechanism and trigger mechanism.
In the above portable fluorescence immunoassay quantitative analyzer, the main injection mechanism includes a main injection hole provided on a side wall of the main injection box, a main filling hole is provided through a bottom of the main injection box, an electromagnetic valve is provided inside the main injection hole, and a main protective bag is fixed on an outer wall of the main injection box.
In the portable fluorescence immunoassay quantitative analyzer, the auxiliary spraying mechanism comprises an auxiliary spraying hole formed in the side wall of the auxiliary spraying box, an auxiliary filling hole penetrates through the bottom of the auxiliary spraying box, and an auxiliary protection bag is fixed on the outer wall of the auxiliary spraying box.
In the portable fluorescence immunoassay quantitative analyzer, the inner wall of the auxiliary spray box is fixed with a pressure-isolating plate, the inner wall of the auxiliary spray box is fixed with a piezoelectric block, the side wall of the pressure-isolating plate and the inner wall of the auxiliary spray box are both connected with an impact block through a return spring, and the piezoelectric block is made of piezoelectric ceramics.
In foretell portable fluorescence immunity quantitative analysis appearance, the outer wall of vice spray box is fixed with the expansion tank, the sealed sliding connection of inner wall of expansion tank has the push rod, the inside packing of expansion tank has electrorheological fluids, the outer wall of vice spray box is connected with the pivot through the torsional spring rotation, the circumference lateral wall of pivot is fixed with baffle and the push pedal that the symmetry set up.
In the above portable fluorescence immunoassay quantitative analyzer, the landing sensing mechanism includes a rotating blade rotatably connected to an inner wall of the air flow groove, and two magnetic blocks are symmetrically fixed to the inner wall of the air flow groove.
In the portable fluorescence immunoassay quantitative analyzer, the power connection mechanism comprises a partition board fixed on the inner wall of the power connection cavity, a through hole is formed in the side wall of the partition board in a penetrating mode, and two power connection strips are jointly fixed on the inner wall of the power connection cavity and the side wall of the partition board.
In the portable fluorescence immunoassay quantitative analyzer, the trigger mechanism comprises a sealing plate fixed on the inner wall of the trigger cavity, the side wall of the sealing plate is penetrated and provided with an open hole, an electromagnetic valve is arranged in the open hole, the two inner walls of the trigger cavity are symmetrically fixed with a photoresistor and a spotlight, and the photoresistor and the spotlight are respectively positioned on two sides of the sealing plate.
Compared with the prior art, the invention has the advantages that:
1. according to the invention, the main protective bag is arranged, so that the machine body can be effectively buffered and protected when the machine body falls carelessly, the machine body is prevented from being damaged due to falling and impact, the service life of the machine body is prolonged, the insecurity caused by portability is effectively overcome, the use safety of equipment is ensured, and the integral performance is further improved;
2. according to the invention, by arranging the counter weight block, when the whole equipment accidentally drops, due to the existence of the counter weight plate, the counter weight plate is positioned at the bottommost part and the equipment is almost in a vertical state, so that the conductive liquid in the power receiving cavity can penetrate through the through hole due to the change of the angle of the equipment when the whole equipment drops, and then enters the other side of the partition plate, and then the two power receiving strips are electrically connected, so that the spotlight electrically emits infrared rays, the dropping process is continuously carried out, the spotlight keeps emitting rays in the dropping process, the first step of starting protection is realized, the random starting of protection measures is avoided, and the intelligent degree is improved;
3. according to the invention, through arranging the rotating blade, the falling process is actually an accelerated motion process of the equipment, the accelerated motion can cause ambient air to be driven to flow, so that air flow is formed around the equipment, under the impact of the air flow, the rotating blade which is originally relatively static can start to rotate, because the rotating blade is positioned in a stable magnetic field formed by two magnetic blocks, the rotating blade is in a state of continuously cutting a magnetic induction line when rotating, a conductive material performs cutting motion in the magnetic field to generate current, the current is determined by the motion speed and the magnetic field intensity, so that the rotating blade can generate current in the falling process of the equipment, the small current is captured and amplified by the equipment, a control switch for opening an electromagnetic valve in a discharge hole is triggered, the protection of the second step of starting is realized through the air flow generated by falling, the falling characteristics are completely matched, and accidental starting is avoided;
4. according to the invention, the auxiliary protection bag is arranged, so that the auxiliary protection bag can be unfolded along with the impact vibration of the machine body after the machine body falls, the auxiliary effect is achieved, the expansion and unfolding degree of the auxiliary protection bag is related to the rotation degree of the baffle, namely the expansion degree of the electrorheological fluid, namely the impact strength of the piezoelectric block, namely the vibration strength formed after the machine body falls, namely the required protection degree of the machine body, and therefore, the higher the required protection degree of the machine body is, the higher the unfolding degree of the auxiliary protection bag is, the linear effective protection can be realized, the waste of compressed gas is avoided, and the cost brought by subsequent inflation is reduced.
Drawings
FIG. 1 is a schematic structural diagram of a portable fluorescence immunoassay analyzer according to the present invention;
FIG. 2 is a sectional view of a weight plate portion of a portable fluorescence immunoassay quantitative analyzer according to the present invention;
FIG. 3 is a sectional view of a sub-spray box portion of a portable fluorescence immunoassay quantitative analyzer according to the present invention;
FIG. 4 is a front view of a sub-tank part of a portable immunofluorescent quantitative analyzer according to the present invention.
In the figure: the device comprises a machine body 1, slots 2, a counterweight plate 3, a main spray box 4, an auxiliary spray box 5, a main protective bag 6, an auxiliary protective bag 7, a main spray hole 8, a main charging hole 9, an airflow groove 10, a rotating blade 11, a magnetic block 12, an electricity connecting cavity 13, a partition plate 14, a through hole 15, an electricity connecting strip 16, a trigger cavity 17, a sealing plate 18, an open hole 19, a photoresistor 20, a spotlight 21, an auxiliary spray hole 22, an auxiliary charging hole 23, an insulating plate 24, a return spring 25, an impact block 26, a piezoelectric block 27, a rotating shaft 28, a baffle 29, a push plate 30, an expansion box 31 and a push rod 32.
Detailed Description
The following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Examples
Referring to fig. 1-4, a portable fluorescence immunoassay quantitative analyzer comprises a body 1, a slot 2 is formed in a side wall of the body 1, a weight plate 3 is fixed at the upper end of the body 1, two main spray boxes 4 are arranged at the upper part of the body 1, two auxiliary spray boxes 5 are arranged at the lower part of the body 1, a main spray mechanism and an auxiliary spray mechanism are respectively arranged on the main spray box 4 and the auxiliary spray boxes 5, an airflow slot 10 is formed in the side wall of the weight plate 3, a landing sensing mechanism is arranged inside the airflow slot 10, an electricity receiving cavity 13 and a trigger cavity 17 are formed in the side wall of the weight plate 3, and an electricity receiving mechanism and a trigger mechanism are respectively arranged inside the electricity receiving cavity 13 and the trigger cavity 17.
The main spraying mechanism comprises a main spraying hole 8 formed in the side wall of the main spraying box 4, a main filling hole 9 penetrates through the bottom of the main spraying box 4, an electromagnetic valve is arranged inside the main spraying hole 8, and a main protection bag 6 is fixed on the outer wall of the main spraying box 4; the auxiliary spraying mechanism comprises an auxiliary spraying hole 22 formed in the side wall of the auxiliary spraying box 5, an auxiliary filling hole 23 penetrates through the bottom of the auxiliary spraying box 5, and an auxiliary protection bag 7 is fixed on the outer wall of the auxiliary spraying box 5.
The inner wall of the auxiliary spraying box 5 is fixedly provided with a pressure-isolating plate 24, the inner wall of the auxiliary spraying box 5 is fixedly provided with a piezoelectric block 27, the side wall of the pressure-isolating plate 24 and the inner wall of the auxiliary spraying box 5 are both connected with an impact block 26 through a return spring 25, the piezoelectric block 27 is made of piezoelectric ceramics, when the machine body 1 collides to generate vibration, the return spring 25 causes the motion of the impact block 26 to be inconsistent with the piezoelectric block 27 due to the spring characteristic of the return spring, and therefore the impact block 26 and the piezoelectric block 27 generate effective collision extrusion in the subsequent process.
The outer wall of vice spray box 5 is fixed with expansion tank 31, the sealed sliding connection of inner wall of expansion tank 31 has push rod 32, the inside packing of expansion tank 31 has electrorheological fluid, the outer wall of vice spray box 5 is connected with pivot 28 through the torsional spring rotation, the circumference lateral wall of pivot 28 is fixed with baffle 29 and the push pedal 30 that the symmetry set up, baffle 29 seals the jam with vice orifice 22, push rod 32 can be out of shape to a certain extent, thereby can promote the effectual deflection of push pedal 30, and then make baffle 29 and vice orifice 22 dislocation.
Descending perception mechanism includes and rotates the commentaries on classics leaf 11 of being connected with air current groove 10 inner wall, and the inner wall symmetry of air current groove 10 is fixed with two magnetic paths 12, and two magnetic paths 12 form stable magnetic field, thereby change leaf 11 can rotate under the air current drive and cut magnetic induction line, and then produce electric current, and this electric current can be caught and enlarged and be used for the trigger equipment to open and close, and when organism 1 normal use, can not the rapid movement with the swing so change leaf 11 can not rotate.
Connect the electric mechanism including being fixed in the baffle 14 that connects the electric cavity 13 inner wall, the through-hole 15 has been seted up in the lateral wall of baffle 14 run through, the inner wall that connects electric cavity 13 is fixed with two electricity connection strips 16 with the lateral wall of baffle 14 jointly, it has the conducting liquid to connect the inside packing of electric cavity 13, trigger after two electricity connection strips 16 electric connection at the conducting liquid and connect the electric equipment, through-hole 15 is located the upper portion of baffle 14, if steadily place the use promptly the organism then connect the position that the electric liquid can't reach through-hole 15, the organism is in the horizontal state of placing during normal use, and two are connect the unable circular telegram of electricity strip 16, will switch on when organism 1 is in the state of falling.
The trigger mechanism comprises a closing plate 18 fixed on the inner wall of the trigger cavity 17, an open hole 19 is formed in the side wall of the closing plate 18 in a penetrating mode, an electromagnetic valve is arranged inside the open hole 19, a photoresistor 20 and a spotlight 21 are symmetrically fixed on the two inner walls of the trigger cavity 17, the photoresistor 20 and the spotlight 21 are respectively located on two sides of the closing plate 18, the photoresistor 20 is an infrared photoresistor, and the spotlight 21 can generate infrared light and is used for changing the resistance value of the photoresistor 20 to control opening and closing of the electromagnetic valve inside the main spray hole 8.
In the invention, when the portable electronic device is used, the machine body 1 has high integration level and extremely small volume, can be directly operated by hands, and only needs to insert the detection reagent strip into the slot 2 for waiting, so that the portable electronic device is convenient to operate and carry;
when the whole device falls accidentally, due to the existence of the weight plate 3, the weight plate 3 is located at the bottommost part and the device is almost in a vertical state, so that the conductive liquid in the electric connection cavity 13 passes through the through hole 15 due to the change of the angle of the device when the device falls, then enters the other side of the partition plate 14, and then the two electric connection strips 16 are electrically connected, so that the spotlight 21 is electrified to emit infrared light, the falling process is continuously carried out, and the spotlight 21 keeps emitting light in the falling process;
the falling process is actually an accelerated motion process of the equipment, the accelerated motion can cause ambient air to be driven to flow, and further airflow is formed around the equipment, under the impact of the airflow, the originally relatively static rotating blade 11 will start to rotate, because the rotating blade 11 is located in a stable magnetic field formed by two magnetic blocks 12, the rotating blade 11 is in a state of continuously cutting magnetic induction lines when rotating, the conducting material performs cutting motion in the magnetic field to generate current, the current is determined by the motion speed and the magnetic field intensity, the rotating blade 11 generates current in the falling process of the equipment, the small current is captured and amplified by the equipment, and therefore a control switch of an electromagnetic valve in the open hole 19 is triggered, the process is circuit control, and no detailed description is given for mature prior art;
along with the opening of the open hole 19, infrared rays emitted by the spot lamp 21 can pass through the open hole 19 and act on the photosensitive resistor 20, so that the resistance value of the photosensitive resistor 20 is reduced, an electromagnetic valve in the main spray hole 8 on the main spray box 4 is opened, compressed gas in the main spray box 4 is quickly released into the main protective bag 6, the main protective bag 6 is quickly inflated and expanded, a protective bag is formed outside the machine body 1, the machine body 1 is buffered and protected after falling, internal components are prevented from being damaged due to direct collision between the machine body 1 and the ground, and the machine body 1 is ensured to be portable and has high safety;
after the machine body 1 falls, the whole equipment inevitably generates certain vibration, the vibration can cause the impact block 26 inside the auxiliary spraying box 5 to collide with the piezoelectric block 27, further the piezoelectric block 27 generates instant high-voltage current due to collision and extrusion, and then the instant high-voltage current acts on the electrorheological fluid inside the expansion box 31, so that the electrorheological fluid is subjected to electric solidification and expands to a certain degree, the push rod 32 is pushed by the electrorheological fluid to move outwards, the push plate 30 is pushed to rotate, the rotating shaft 28 drives the baffle plate 29 to rotate, the baffle plate 29 cannot completely shield the auxiliary spray holes 22, compressed gas inside the auxiliary spraying box 5 is sprayed, the auxiliary protection bag 7 expands to play a protection role, and the auxiliary protection bag 7 is unfolded after the equipment falls to the ground to reduce subsequent rolling collision damage and play an auxiliary role, so that the complete expansion is not needed;
the expansion degree of the electrorheological fluid is related to the rotation degree of the baffle 29, that is, the expansion degree of the electrorheological fluid, that is, the strength of the impact on the piezoelectric block 27, that is, the vibration strength formed after the body 1 falls, that is, the degree of protection required by the body 1, and thus, the higher the expansion degree of the auxiliary protection bag 7 is, the higher the degree of protection required by the body 1 is, the linear effective protection can be realized, the waste of compressed gas is avoided, and the cost caused by subsequent inflation is reduced.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (5)

1. A portable fluorescence immunoassay quantitative analyzer comprises a machine body (1), and is characterized in that a slot (2) is formed in the side wall of the machine body (1), a weight plate (3) is fixed at the upper end of the machine body (1), two main spray boxes (4) are arranged at the upper part of the machine body (1), two auxiliary spray boxes (5) are arranged at the lower part of the machine body (1), a main spray mechanism and an auxiliary spray mechanism are respectively arranged on the main spray box (4) and the auxiliary spray boxes (5), an airflow slot (10) is formed in the side wall of the weight plate (3), a landing sensing mechanism is arranged inside the airflow slot (10), an electricity receiving cavity (13) and a trigger cavity (17) are formed in the side wall of the weight plate (3), and an electricity receiving mechanism and a trigger mechanism are respectively arranged inside the electricity receiving cavity (13) and the trigger cavity (17);
the auxiliary spraying mechanism comprises an auxiliary spraying hole (22) formed in the side wall of the auxiliary spraying box (5), an auxiliary filling hole (23) penetrates through the bottom of the auxiliary spraying box (5), and an auxiliary protection bag (7) is fixed on the outer wall of the auxiliary spraying box (5);
a pressure isolating plate (24) is fixed on the inner wall of the auxiliary spray box (5), a piezoelectric block (27) is fixed on the inner wall of the auxiliary spray box (5), the side wall of the pressure isolating plate (24) and the inner wall of the auxiliary spray box (5) are both connected with an impact block (26) through a return spring (25), and the piezoelectric block (27) is made of piezoelectric ceramics;
the outer wall of vice spray box (5) is fixed with expansion tank (31), the sealed sliding connection of inner wall of expansion tank (31) has push rod (32), the inside packing of expansion tank (31) has electrorheological fluids, the outer wall of vice spray box (5) is connected with pivot (28) through the torsional spring rotation, the circumference lateral wall of pivot (28) is fixed with baffle (29) and push pedal (30) that the symmetry set up.
2. The portable fluorescence immunoassay quantitative analyzer according to claim 1, wherein the main injection mechanism comprises a main injection hole (8) formed in a side wall of the main injection box (4), a main filling hole (9) is formed through the bottom of the main injection box (4), an electromagnetic valve is arranged inside the main injection hole (8), and a main protection bag (6) is fixed on an outer wall of the main injection box (4).
3. The portable fluoroimmunoassay quantitative analyzer according to claim 1, wherein the landing sensing mechanism comprises a rotating blade (11) rotatably connected with the inner wall of the air flow groove (10), and two magnetic blocks (12) are symmetrically fixed on the inner wall of the air flow groove (10).
4. The portable fluorescence immunoassay quantitative analyzer according to claim 1, wherein the power connection mechanism comprises a partition plate (14) fixed on the inner wall of the power connection chamber (13), a through hole (15) is formed through the side wall of the partition plate (14), and two power connection strips (16) are fixed on the inner wall of the power connection chamber (13) and the side wall of the partition plate (14) together.
5. The portable fluorescence immunoassay quantitative analyzer of claim 1, wherein the trigger mechanism comprises a closing plate (18) fixed on an inner wall of the trigger cavity (17), an open hole (19) is formed through a side wall of the closing plate (18), an electromagnetic valve is arranged inside the open hole (19), a photoresistor (20) and a spot light (21) are symmetrically fixed on two inner walls of the trigger cavity (17), and the photoresistor (20) and the spot light (21) are respectively located on two sides of the closing plate (18).
CN202110799569.9A 2021-07-15 2021-07-15 Portable fluorescence immunoassay quantitative analyzer Active CN113640507B (en)

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CN112937891A (en) * 2021-03-30 2021-06-11 宗国菊 Safe unmanned aerial vehicle with protection function falls
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CN204979255U (en) * 2015-06-12 2016-01-20 陈志新 Controllable type helium parachute
CN105217406A (en) * 2015-09-26 2016-01-06 梁纲 The inner box body device with air bag
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CN208155453U (en) * 2018-04-28 2018-11-27 厦门谱识科仪有限公司 A kind of Raman spectrometer shatter-resistant shell
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Inventor after: Cui Zhilong

Inventor after: He Wanyuan

Inventor after: Wang Luo

Inventor after: Jia Yinliang

Inventor after: Zhang Linshuai

Inventor after: Zhao Jiankai

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Denomination of invention: A portable fluorescence immunoassay quantitative analyzer

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