CN113640242A - Portable liver total reserve function detector and method based on infrared light absorption - Google Patents
Portable liver total reserve function detector and method based on infrared light absorption Download PDFInfo
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- 210000004185 liver Anatomy 0.000 title claims abstract description 33
- 230000031700 light absorption Effects 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 claims abstract description 92
- 230000003287 optical effect Effects 0.000 claims abstract description 24
- 239000003570 air Substances 0.000 claims description 115
- 239000012080 ambient air Substances 0.000 claims description 29
- 230000006835 compression Effects 0.000 claims description 13
- 238000007906 compression Methods 0.000 claims description 13
- 239000000523 sample Substances 0.000 claims description 13
- 230000001186 cumulative effect Effects 0.000 claims description 8
- 210000003494 hepatocyte Anatomy 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000037323 metabolic rate Effects 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 239000012496 blank sample Substances 0.000 claims description 4
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- 239000005758 Cyprodinil Substances 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 3
- 230000006870 function Effects 0.000 description 23
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- 239000007864 aqueous solution Substances 0.000 description 2
- VNWKTOKETHGBQD-OUBTZVSYSA-N carbane Chemical compound [13CH4] VNWKTOKETHGBQD-OUBTZVSYSA-N 0.000 description 2
- 210000005229 liver cell Anatomy 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- 102000019298 Lipocalin Human genes 0.000 description 1
- 108050006654 Lipocalin Proteins 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
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- Investigating Or Analysing Materials By Optical Means (AREA)
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Abstract
The invention discloses a portable liver overall storage function detector and a method based on infrared light absorption, and the detector comprises a detector box body, a main air chamber, an auxiliary air chamber, a main black body infrared light source, an auxiliary black body infrared light source, a main infrared light sensor, an auxiliary infrared light sensor, a main reference passage, a main detection passage, an auxiliary reference passage, an auxiliary detection passage, a main collimation plano-concave lens, a main reference plano-concave lens, a main detection plano-concave lens, an auxiliary collimation plano-concave lens, an auxiliary reference plano-concave lens, an auxiliary detection plano-concave lens, an optical filter, a locking component, a positioning column, a connecting plate, a connecting screw, a box cover, an air inlet nozzle and an air outlet nozzle; the invention combines infrared light gas detection and 13C-cyprodinil expiration experiment to complete liver total reserve function detection, can replace an isotope mass spectrometer with large volume and heavy weight, has small volume, light weight, easy carrying and higher detection precision, can adapt to complex application scenes, and has higher market value.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a portable liver overall reserve function detector and a method based on infrared light absorption.
Background
The liver plays a very important role in the life activities of human bodies, has very complex and important physiological functions, and the reserve function of the liver is an index reflecting the overall potential of the liver and contains the sum of all liver cells capable of playing normal physiological functions. Clinically, the detection indexes such as ALT, AST, ALB, GGT, TBIL, DBIL, PT, APIT and the like which are commonly used can only statically detect the concentration of a specific substance in serum at a certain time, only reflect the damage degree of liver cells, and cannot quantitatively detect the reserve function of the liver.
However, the current methods for determining the overall reserve function of the liver mainly include: firstly, the lipocalin sodium, indocyanine green, sorbitol and the like are used for evaluating the liver function, but the method needs repeated blood sampling, the cost is high due to long-term tube placement, and the patient has the risk of anaphylactic reaction, so the method cannot be widely used; secondly, a Child-Pugh scoring system is used, and is the most common model for scholars at home and abroad to judge the liver storage function and prognosis of the cirrhosis patients at present, but Child-Pugh grading has certain limitation, grading results change along with treatment, and the liver function cannot be effectively quantitatively evaluated; thirdly, the 13C breath test is used for quantitative analysis, and the method has obtained certain experience at home and abroad at present. However, it is more common in the 13C-phenylalanine breath test, whereas the 13C-cyprodinil breath test is less common. In addition, the isotope mass spectrometer is generally used for detecting the total reserve function state of the liver clinically, and has the advantages of large volume, heavy weight, high manufacturing cost, difficulty in transportation and carrying, complex structure, high maintenance cost, low detection precision, incapability of adapting to complex application scenes and limited market value.
Disclosure of Invention
The invention aims to provide a portable liver total reserve function detector and a method based on infrared light absorption, and aims to solve the problems of difficulty in transportation and carrying, high maintenance cost and low detection precision in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a portable liver overall storage function detector based on infrared light absorption comprises a detector box body, a main air chamber, an auxiliary air chamber, a main black body infrared light source, an auxiliary black body infrared light source, a main infrared light sensor, an auxiliary infrared light sensor, a main reference channel, a main detection channel, an auxiliary reference channel, an auxiliary detection channel, a main collimation plano-concave lens, a main reference plano-concave lens, a main detection plano-concave lens, an auxiliary collimation plano-concave lens, an auxiliary reference plano-concave lens, an auxiliary detection plano-concave lens, an optical filter, a locking assembly, a positioning column, a connecting plate, a connecting screw, a box cover, an air inlet nozzle and an air outlet nozzle, wherein the main air chamber and the auxiliary air chamber are respectively arranged on two sides of the top of the detector box body, the main black body infrared light source and the auxiliary black body infrared light source are respectively and fixedly arranged at one end of the main air chamber and the auxiliary air chamber respectively, the output ends of the main infrared light sensor and the auxiliary infrared light sensor are fixedly connected with the input end of an upper computer through cables, the input ends of the main infrared light sensor and the auxiliary infrared light sensor are respectively provided with a main reference passage, a main detection passage, an auxiliary reference passage and an auxiliary detection passage, the sides of the main black body infrared light source, the main reference passage, the main detection passage, the auxiliary black body infrared light source, the auxiliary reference passage and the auxiliary detection passage are respectively provided with a main collimation plano-concave lens, a main reference plano-concave lens, a main detection plano-concave lens, an auxiliary collimation plano-concave lens, an auxiliary reference plano-concave lens and an auxiliary detection plano-concave lens, and the side of the auxiliary collimation plano-concave lens is provided with an optical filter.
Preferably, the primary collimation plano-concave lens, the primary reference plano-concave lens, the primary detection plano-concave lens, the secondary collimation plano-concave lens, the secondary reference plano-concave lens, the secondary detection plano-concave lens and the optical filter are respectively and fixedly embedded in the primary air chamber and the secondary air chamber through a linkage assembly, the locking assembly comprises a first fixed mirror frame, a second fixed mirror frame and a first ring groove, first spacing ring, the locking screw, first picture frame that compresses tightly, the second annular, second spacing ring and second compress tightly the picture frame and constitute, first fixed picture frame and the fixed picture frame of second are all fixed to be inlayed and are being adorned in the inside of main air chamber and auxiliary air chamber, the center of first fixed picture frame side is inlayed through first annular and first spacing ring respectively and is equipped with main collimation plano-concave lens, vice detection plano-concave lens and light filter, the four corners of first fixed picture frame side is through locking screw and the first four corners fixed connection who compresses tightly the picture frame side.
Preferably, the two ends of the side surface of the second fixed mirror frame are respectively embedded with a main reference plano-concave lens, a main detection plano-concave lens, an auxiliary reference plano-concave lens and an auxiliary detection plano-concave lens through a second ring groove and a second limiting ring, and the four corners, the top end and the bottom end of the side surface of the second fixed mirror frame are fixedly connected with the four corners, the top end and the bottom end of the side surface of the second compression mirror frame through locking screw holes and locking screws.
Preferably, the outer edge of the top of the box body of the detector is fixedly connected with the outer edge of the bottom of the box cover through a positioning column, a connecting plate and a connecting screw, the two sides of the top of the box cover are respectively provided with an air inlet nozzle and an air outlet nozzle, and the air inlet nozzle and the air outlet nozzle are communicated with the main air chamber and the auxiliary air chamber in a gas phase mode.
Preferably, the first ring groove is respectively arranged at the inner edges of the side surfaces of the first fixed mirror frame and the first compression mirror frame, a first limit ring is embedded in the first ring groove, and the first limit ring is respectively arranged on the outer circumferences of the primary collimation plano-concave lens, the secondary detection plano-concave lens and the optical filter.
Preferably, the locking screw holes are respectively arranged at four sides of the first fixed picture frame and the first compression picture frame and at four sides, the top end and the bottom end of the second fixed picture frame and the second compression picture frame, and locking screws are embedded in the locking screw holes.
Preferably, the second annular groove is respectively formed in the inner edges of the side surfaces of the second fixed mirror frame and the second compression mirror frame, a second limiting ring is embedded in the second annular groove, and the second limiting ring is respectively arranged on the outer circumferences of the main reference plano-concave lens, the main detection plano-concave lens, the auxiliary reference plano-concave lens and the auxiliary detection plano-concave lens.
The portable liver overall reserve function detection method based on infrared light absorption comprises the following steps of firstly, zero point calibration; step two, blank test; step three, oral test; step four, judging the state;
in the first step, after the power supply is switched on and the detector is preheated for 30 minutes, the ambient air and the infrared light source of the main black body are respectively introduced into the main air chamber and the auxiliary air chamber through the air inlet nozzles on the box coverThe emitted black body infrared light is refracted by the primary collimation plano-concave lens to form black body infrared parallel light, the black body infrared parallel light irradiates ambient air in the primary air chamber, and the black body infrared parallel light irradiates a primary reference channel and a primary detection channel respectively after being refracted and focused by the primary reference plano-concave lens and the primary detection plano-concave lens, so that an optical signal is converted into an electric signal, a voltage signal is transmitted to an upper computer through the primary infrared light sensor, and CO of the ambient air is obtained2The total concentration, the black body infrared light emitted by the auxiliary black body infrared light source is refracted into black body infrared parallel light by the auxiliary collimating plano-concave lens, the ambient air in the auxiliary air chamber is irradiated, and the black body infrared parallel light is blocked by the optical filter13CO2After light absorption in the wavelength band, make12CO2The absorption light wave band is refracted and focused by the auxiliary reference plano-concave lens and the auxiliary detection plano-concave lens and then respectively irradiates the auxiliary reference channel and the auxiliary detection channel, so that the light signal is converted into an electric signal, and then the voltage signal is transmitted to an upper computer through the auxiliary infrared light sensor to obtain the ambient air12CO2Concentration, and finally passing CO through the upper computer2Total concentration of12CO2Difference of concentration, calculating ambient air13CO2Carrying out zero calibration on abundance to obtain a zero sample, and exhausting ambient air through an air outlet nozzle on the box cover;
in the second step, after the testee fasts and forbids water for eight hours, the exhaled gas of the human body is respectively introduced into the main air chamber and the auxiliary air chamber through the air inlet nozzle on the box cover for four to eight seconds, and then the process in the first step is carried out to obtain the exhaled gas of the human body13CO2Abundance, and as a blank specimen;
in the third step, 75mg of 13C-pyrimethacin is fully dissolved in 100ml of warm boiled water, 30 minutes, 60 minutes and 120 minutes after the tested person takes the medicine orally are respectively introduced into the main air chamber and the auxiliary air chamber through the air inlet nozzle on the box cover, and then the flow in the first step is carried out to obtain the 30 minutes, 60 minutes and 120 minutes of the orally taken exhaled air of the human body13CO2Abundance, and as a test specimen;
in the fourth step, the upper computer utilizes the zero obtained in the first stepRespectively drawing a DOB curve, a metabolic rate curve and an accumulated abundance curve for the point sample and the blank sample and the test sample obtained in the step two, further respectively calculating DOB values in 30 minutes, 60 minutes and 120 minutes, and further respectively calculating exhaled breath values in 30 minutes, 60 minutes and 120 minutes13CO2Abundance being the total exhale amount13CO2Percent abundance, obtained at 30 min, 60 min and 120 min13CO2The exhalation rate, and thus the cumulative exhalation before 30 minutes, 60 minutes, and 120 minutes as a percentage of the total amount expected to be exhaled, is calculated to yield cumulative exhalations before 30 minutes, 60 minutes, and 120 minutes13CO2Sum of abundances, calculated for 120 minutes13CO2And accumulating the ratio of the exhaling abundance to the normal value to obtain a Cum120 value, namely a hepatocyte compensation index, and judging the hepatocyte compensation function state of the tested person.
Compared with the prior art, the invention has the beneficial effects that: the invention combines infrared light gas detection and 13C-pyrimethacin expiration experiments, detects the concentration of isotope labeled gas in exhaled gas after 13C-pyrimethacin aqueous solution is orally taken based on an infrared light absorption method, converts the concentration ratio change into the ratio change of 13C isotope relative abundance, calculates DOB value, metabolic rate value and Cum value of data acquired at specific time of a patient, judges the liver reserve function condition of the patient by contrasting standard data, completes the detection of the overall liver reserve function, can replace an isotope mass spectrometer with large volume and heavy weight, has small volume, light weight, easy carrying and higher detection precision, can adapt to complex application scenes, and has higher market value; the lens component is locked by additionally arranging the locking structure, so that the shaking of the lens component is reduced, the infrared ray deviation in the use process is avoided, and the detection precision of the portable liver overall storage function detector is ensured; by additionally arranging the connecting structure, the detector is convenient to mount and dismount, the maintenance and replacement difficulty of easily damaged parts is reduced, and the use cost of the portable liver overall storage function detector is saved.
Drawings
FIG. 1 is a front view of the overall structure of the present invention;
FIG. 2 is a left side cross-sectional view of the overall construction of the present invention;
FIG. 3 is a top view of the overall structure of the present invention;
FIG. 4 is a top cross-sectional view of the overall structure of the present invention;
FIG. 5 is a perspective view of a first fixed frame of the present invention;
FIG. 6 is a perspective view of a second fixed frame of the present invention;
FIG. 7 is a flow chart of a method of the present invention;
in the figure: 1. a detector box body; 2. a main air chamber; 3. an auxiliary air chamber; 4. a main black body infrared light source; 5. an auxiliary black body infrared light source; 6. a primary infrared light sensor; 7. a secondary infrared light sensor; 8. a main reference path; 9. a main detection path; 10. a secondary reference path; 11. a secondary detection path; 12. a primary collimating plano-concave lens; 13. a main reference plano-concave lens; 14. a main detection plano-concave lens; 15. a secondary collimating plano-concave lens; 16. a sub-reference plano-concave lens; 17. a secondary detection plano-concave lens; 18. an optical filter; 19. a locking assembly; 1901. a first fixed frame; 1902. a second fixed frame; 1903. a first ring groove; 1904. a first limit ring; 1905. locking the screw hole; 1906. locking the screw; 1907. a first compression frame; 1908. a second ring groove; 1909. a second stop collar; 1910. a second compression frame; 20. a positioning column; 21. a connecting plate; 22. a connecting screw; 23. a box cover; 24. an air inlet nozzle; 25. an air outlet nozzle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-6, an embodiment of the present invention is shown: a portable liver overall storage function detector based on infrared light absorption comprises a detector box body 1, a main air chamber 2, an auxiliary air chamber 3, a main black body infrared light source 4, an auxiliary black body infrared light source 5, a main infrared light sensor 6, an auxiliary infrared light sensor 7, a main reference passage 8, a main detection passage 9, an auxiliary reference passage 10, an auxiliary detection passage 11, a main collimation plano-concave lens 12, a main reference plano-concave lens 13, a main detection plano-concave lens 14, an auxiliary collimation plano-concave lens 15, an auxiliary reference plano-concave lens 16, an auxiliary detection plano-concave lens 17, an optical filter 18, a locking assembly 19, a positioning column 20, a connecting plate 21, a connecting screw 22, a box cover 23, an air inlet nozzle 24 and an air outlet nozzle 25, wherein the main air chamber 2 and the auxiliary air chamber 3 are respectively arranged on two sides of the top of the detector box body 1, the main air chamber 2 and one end of the auxiliary air chamber 3 are respectively fixedly provided with the main black body infrared light source 4 and the auxiliary black body infrared light source 5, a main infrared light sensor 6 and an auxiliary infrared light sensor 7 are respectively and fixedly installed at the other ends of the main air chamber 2 and the auxiliary air chamber 3, the output ends of the main infrared light sensor 6 and the auxiliary infrared light sensor 7 are fixedly connected with the input end of an upper computer through cables, a main reference passage 8, a main detection passage 9, an auxiliary reference passage 10 and an auxiliary detection passage 11 are respectively arranged at the input ends of the main infrared light sensor 6 and the auxiliary infrared light sensor 7, a main collimation plano-concave lens 12, a main reference plano-concave lens 13, a main detection plano-concave lens 14, an auxiliary collimation plano-concave lens 15, an auxiliary reference plano-concave lens 16 and an auxiliary detection plano-concave lens 17 are respectively arranged at the side parts of the main infrared light source 4, the main reference passage 8, the main detection passage 9, the auxiliary black infrared light source 5, the auxiliary reference passage 10 and the auxiliary detection passage 11, a light filter 18 is arranged at the side part of the auxiliary collimation plano-concave lens 15, the main collimation plano-concave lens 12, a sub-concave lens 7, The main reference plano-concave lens 13, the main detection plano-concave lens 14, the auxiliary collimation plano-concave lens 15, the auxiliary reference plano-concave lens 16, the auxiliary detection plano-concave lens 17 and the optical filter 18 are respectively and fixedly embedded in the main air chamber 2 and the auxiliary air chamber 3 through the interlocking component 19, the locking component 19 is composed of a first fixed picture frame 1901, a second fixed picture frame 1902, a first ring groove 1903, a first limit ring 1904, a locking screw hole 1905, a locking screw 1906, a first compacting picture frame 1907, a second ring groove 1908, a second limit ring 1909 and a second compacting picture frame 1910, the first fixed picture frame 1901 and the second fixed picture frame 1902 are respectively and fixedly embedded in the main air chamber 2 and the auxiliary air chamber 3, the main collimation plano-concave lens 12, the auxiliary detection plano-concave lens 17 and the optical filter 18 are respectively embedded in the center of the side surface of the first fixed picture frame 1901 through the first ring groove 1903 and the first limit ring 1904, the first ring groove 1903 is respectively arranged in the inner edge of the side surface of the first compacting picture frame 1901 and the first compacting picture frame 1907, a first limit ring 1904 is embedded in the first ring groove 1903, the first limit ring 1904 is respectively arranged on the outer circumference of the primary collimating plano-concave lens 12, the secondary detecting plano-concave lens 17 and the optical filter 18, four corners of the side surface of the first fixed mirror frame 1901 are fixedly connected with four corners of the side surface of the first hold-down mirror frame 1907 through locking screw holes 1905 and locking screws 1906, the locking screw holes 1905 are respectively arranged on four corners of the side surfaces of the first fixed mirror frame 1901 and the first hold-down mirror frame 1907 and four corners, top end and bottom end of the side surfaces of the second fixed mirror frame 1902 and the second hold-down mirror frame 1910, the locking screw holes 1905 are embedded in the locking screws 1906, the primary reference plano-concave lens 13, the primary detecting plano-concave lens 14, the secondary reference plano-concave lens 16 and the secondary detecting plano-concave lens 17 are respectively embedded in two ends of the side surface of the second fixed mirror frame 1902 through a second ring groove 1908 and a second limit ring 1909, the second ring groove 1908 is respectively arranged on the inner edge of the side surfaces of the second fixed mirror frame 1902 and the second hold-down mirror frame 1910, a second limiting ring 1909 is embedded in the second annular groove 1908, the second limiting ring 1909 is respectively arranged on the outer circumferences of the main reference plano-concave lens 13, the main detection plano-concave lens 14, the auxiliary reference plano-concave lens 16 and the auxiliary detection plano-concave lens 17, the four corners, the top end and the bottom end of the side surface of the second fixed lens frame 1902 are fixedly connected with the four corners, the top end and the bottom end of the side surface of the second compression lens frame 1910 through locking screw holes 1905 and locking screws 1906, and the lens component is locked by additionally arranging a locking structure, so that the shaking of the lens component is reduced, the infrared deviation in the using process is avoided, and the detection precision of the portable liver overall storage function detector is ensured; the outer edge of the top of the detector box body 1 is fixedly connected with the outer edge of the bottom of the box cover 23 through the positioning column 20, the connecting plate 21 and the connecting screw 22, the two sides of the top of the box cover 23 are respectively provided with an air inlet nozzle 24 and an air outlet nozzle 25, and the air inlet nozzle 24 and the air outlet nozzle 25 are communicated with the main air chamber 2 and the auxiliary air chamber 3 in a gas phase mode. By additionally arranging the connecting structure, the detector is convenient to mount and dismount, the maintenance and replacement difficulty of easily damaged parts is reduced, and the use cost of the portable liver overall storage function detector is saved.
Referring to fig. 7, an embodiment of the present invention: the portable liver overall reserve function detection method based on infrared light absorption comprises the following steps of firstly, zero point calibration; step two, blank test; step three, oral test; step four, judging the state;
in the first step, after the power is switched on and the detector is preheated for 30 minutes, ambient air is respectively introduced into the main air chamber 2 and the auxiliary air chamber 3 through the air inlet nozzle 24 on the box cover 23, black body infrared light rays emitted by the main black body infrared light source 4 are refracted into black body infrared parallel light rays through the main collimating plano-concave lens 12 to irradiate the ambient air in the main air chamber 2, and then the black body infrared parallel light rays are refracted and focused through the main reference plano-concave lens 13 and the main detection plano-concave lens 14 and then respectively irradiate on the main reference channel 8 and the main detection channel 9 to convert optical signals into electrical signals, and then voltage signals are transmitted to an upper computer through the main infrared light sensor 6 to obtain CO of the ambient air2The total concentration, and simultaneously the black body infrared light emitted by the auxiliary black body infrared light source 5 is refracted into black body infrared parallel light by the auxiliary collimating plano-concave lens 15, irradiates the ambient air in the auxiliary air chamber 3, and is blocked by the optical filter 1813CO2After light absorption in the wavelength band, make12CO2The absorption light wave band is refracted and focused by the auxiliary reference plano-concave lens 16 and the auxiliary detection plano-concave lens 17 and then respectively irradiates the auxiliary reference channel 10 and the auxiliary detection channel 11, so that the light signal is converted into an electric signal, and further the voltage signal is transmitted to an upper computer through the auxiliary infrared light sensor 7 to obtain the ambient air12CO2Concentration, and finally passing CO through the upper computer2Total concentration of12CO2Difference of concentration, calculating ambient air13CO2Carrying out zero calibration on abundance to obtain a zero sample, and exhausting ambient air through an air outlet 25 on the box cover 23;
in the second step, after the testee fasts and forbids water for eight hours, the exhaled gas of the human body is respectively introduced into the main air chamber 2 and the auxiliary air chamber 3 through the air inlet nozzle 24 on the box cover 23 for four to eight seconds, and then the exhaled gas of the human body is obtained through the flow in the first step13CO2Abundance, and as a blank specimen;
in the third step, 75mg of 13C-pyrimethacin is fully dissolved in 100ml of warm boiled water, 30 minutes, 60 minutes and 120 minutes after the oral administration of a tested person are respectively introduced into the main air chamber 2 and the auxiliary air chamber 3 through the air inlet nozzle 24 on the box cover 23, and 30 minutes, 60 minutes and 120 minutes of the oral exhaled air of the human body are obtained through the process in the first step13CO2Abundance, and as a test specimen;
in the fourth step, the upper computer respectively draws a DOB curve, a metabolic rate curve and an accumulated abundance curve by using the zero point sample obtained in the first step and the blank sample and the test sample obtained in the second step, further respectively calculates DOB values of 30 minutes, 60 minutes and 120 minutes, and further respectively calculates exhaled breath values of 30 minutes, 60 minutes and 120 minutes13CO2Abundance being the total exhale amount13CO2Percent abundance, obtained at 30 min, 60 min and 120 min13CO2The exhalation rate, and thus the cumulative exhalation before 30 minutes, 60 minutes, and 120 minutes as a percentage of the total amount expected to be exhaled, is calculated to yield cumulative exhalations before 30 minutes, 60 minutes, and 120 minutes13CO2Sum of abundances, calculated for 120 minutes13CO2And accumulating the ratio of the exhaling abundance to the normal value to obtain a Cum120 value, namely a hepatocyte compensation index, and judging the hepatocyte compensation function state of the tested person.
The working principle is as follows: when the detector is used, a power supply is firstly switched on, the detector is preheated for 30 minutes, then the ambient air is respectively introduced into the main air chamber 2 and the auxiliary air chamber 3 through the air inlet nozzle 24 on the box cover 23, black body infrared rays emitted by the main black body infrared light source 4 are refracted into black body infrared parallel rays through the main collimating plano-concave lens 12 to irradiate the ambient air in the main air chamber 2, and then the black body infrared parallel rays are refracted and focused through the main reference plano-concave lens 13 and the main detection plano-concave lens 14 and respectively irradiate on the main reference channel 8 and the main detection channel 9 to convert optical signals into electric signals, and further the voltage signals are transmitted to an upper computer through the main infrared light sensor 6 to obtain CO of the ambient air2Total concentration, and black body infrared light emitted by the auxiliary black body infrared light source 5 is collimated by the auxiliary collimating plano-concaveThe lens 15 refracts the black body infrared parallel light rays to irradiate the ambient air in the auxiliary air chamber 3, and then the ambient air is blocked by the optical filter 1813CO2After light absorption in the wavelength band, make12CO2The absorption light wave band is refracted and focused by the auxiliary reference plano-concave lens 16 and the auxiliary detection plano-concave lens 17 and then respectively irradiates the auxiliary reference channel 10 and the auxiliary detection channel 11, so that the light signal is converted into an electric signal, and further the voltage signal is transmitted to an upper computer through the auxiliary infrared light sensor 7 to obtain the ambient air12CO2Concentration, and finally passing CO through the upper computer2Total concentration of12CO2Difference of concentration, calculating ambient air13CO2The abundance is calibrated at zero point to obtain a zero point sample, the ambient air is emptied through the air outlet nozzle 25 on the box cover 23, then the testee fasts and forbids water for eight hours, the air inlet nozzle 24 on the box cover 23 respectively leads the exhaled air of the human body into the main air chamber 2 and the auxiliary air chamber 3 for four to eight seconds, and then the flow in the step one is carried out to obtain the exhaled air of the human body13CO2Abundance, and as a blank specimen; then, 75mg of 13C-pyricillus is fully dissolved in 100ml of warm boiled water, 30 minutes, 60 minutes and 120 minutes after the oral administration of a tested person are respectively introduced into the main air chamber 2 and the auxiliary air chamber 3 through the air inlet nozzle 24 on the box cover 23 to orally breathe out gas of the human body, and then the flow in the step one is adopted to obtain the 30 minutes, 60 minutes and 120 minutes of orally breathing out gas of the human body13CO2And abundance as a test sample, drawing a DOB curve, a metabolic rate curve and an accumulated abundance curve by the upper computer by using the zero point sample obtained in the step one and the blank sample and the test sample obtained in the step two, calculating the DOB values of 30 minutes, 60 minutes and 120 minutes, and calculating the exhalation values of 30 minutes, 60 minutes and 120 minutes13CO2Abundance being the total exhale amount13CO2Percent abundance, obtained at 30 min, 60 min and 120 min13CO2The exhalation rate, and thus the cumulative exhalation before 30 minutes, 60 minutes, and 120 minutes as a percentage of the total amount expected to be exhaled, is calculated to yield cumulative exhalations before 30 minutes, 60 minutes, and 120 minutes13CO2Sum of abundances, calculated for 120 minutes13CO2Accumulating the ratio of the exhale abundance to the normal value to obtain a Cum120 value, namely a hepatocyte compensation index, judging the hepatocyte compensation function state of the tested person, combining infrared light gas detection with a 13C-cyprodinil expiration experiment, detecting the concentration of isotope labeled gas in expired gas after oral administration of 13C-cyprodinil aqueous solution based on an infrared light absorption method, converting the concentration ratio change into the ratio change of 13C isotope relative abundance, calculating DOB value, metabolic rate value and Cum value of data collected at specific time of patient, judging liver reserve function condition of patient by comparing with standard data, completing liver overall reserve function detection, the isotope mass spectrometer can replace an isotope mass spectrometer which is large in size and heavy in weight, is small in size, light in weight, easy to carry, high in detection precision, capable of adapting to complex application scenes and high in market value.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (8)
1. A portable liver total reserve function detector based on infrared light absorption comprises a detector box body (1), a main air chamber (2), an auxiliary air chamber (3), a main black body infrared light source (4), an auxiliary black body infrared light source (5), a main infrared light sensor (6), an auxiliary infrared light sensor (7), a main reference channel (8), a main detection channel (9), an auxiliary reference channel (10), an auxiliary detection channel (11) and a main collimation plano-concave lens (12), the main reference plano-concave lens (13), the main detection plano-concave lens (14), the auxiliary collimation plano-concave lens (15), the auxiliary reference plano-concave lens (16), the auxiliary detection plano-concave lens (17), the optical filter (18), the locking component (19), the positioning column (20), the connecting plate (21), the connecting screw (22), the box cover (23), the air inlet nozzle (24) and the air outlet nozzle (25), and the air inlet nozzle is characterized in that: the detector comprises a detector box body (1), wherein a main air chamber (2) and an auxiliary air chamber (3) are respectively arranged on two sides of the top of the detector box body (1), one end of the main air chamber (2) and one end of the auxiliary air chamber (3) are respectively and fixedly provided with a main black body infrared light source (4) and an auxiliary black body infrared light source (5), the other end of the main air chamber (2) and the other end of the auxiliary air chamber (3) are respectively and fixedly provided with a main infrared light sensor (6) and an auxiliary infrared light sensor (7), the output ends of the main infrared light sensor (6) and the auxiliary infrared light sensor (7) are fixedly connected with the input end of an upper computer through cables, the input ends of the main infrared light sensor (6) and the auxiliary infrared light sensor (7) are respectively provided with a main reference channel (8), a main detection channel (9), an auxiliary reference channel (10) and an auxiliary detection channel (11), the main black body infrared light source (4), the main reference channel (8), the main detection channel (9), The side of the auxiliary blackbody infrared light source (5), the auxiliary reference channel (10) and the auxiliary detection channel (11) is respectively provided with a main collimation plano-concave lens (12), a main reference plano-concave lens (13), a main detection plano-concave lens (14), an auxiliary collimation plano-concave lens (15), an auxiliary reference plano-concave lens (16) and an auxiliary detection plano-concave lens (17), and the side of the auxiliary collimation plano-concave lens (15) is provided with an optical filter (18).
2. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 1, wherein: the primary collimation plano-concave lens (12), the primary reference plano-concave lens (13), the primary detection plano-concave lens (14), the secondary collimation plano-concave lens (15), the secondary reference plano-concave lens (16), the secondary detection plano-concave lens (17) and the optical filter (18) are respectively fixedly embedded in the main air chamber (2) and the secondary air chamber (3) through the interlocking fixing component (19), the locking component (19) is composed of a first fixed mirror frame (1901), a second fixed mirror frame (1902), a first annular groove (1903), a first limit ring (1904), a locking screw hole (1905), a locking screw (1906), a first compression mirror frame (1907), a second annular groove (1908), a second limit ring (1909) and a second compression mirror frame (1910), the first fixed mirror frame (1901) and the second fixed mirror frame (1902) are respectively fixedly embedded in the main air chamber (2) and the secondary air chamber (3), and the center of the side surface of the first fixed mirror frame (1901) is respectively embedded in the first limit ring groove (1903) and the first limit ring (1904) Collimation plano-concave lens (12), auxiliary detection plano-concave lens (17) and optical filter (18), the four corners of the side surface of the first fixed mirror frame (1901) are fixedly connected with the four corners of the side surface of the first pressing mirror frame (1907) through locking screw holes (1905) and locking screws (1906).
3. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 1, wherein: the two ends of the side face of the second fixed spectacle frame (1902) are respectively embedded with a main reference plano-concave lens (13), a main detection plano-concave lens (14), an auxiliary reference plano-concave lens (16) and an auxiliary detection plano-concave lens (17) through a second ring groove (1908) and a second limit ring (1909), and the four corners, the top end and the bottom end of the side face of the second fixed spectacle frame (1902) are fixedly connected with the four corners, the top end and the bottom end of the side face of the second compression spectacle frame (1910) through locking screw holes (1905) and locking screws (1906).
4. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 1, wherein: the outer edge of the top of the detector box body (1) is fixedly connected with the outer edge of the bottom of the box cover (23) through a positioning column (20), a connecting plate (21) and a connecting screw (22), the two sides of the top of the box cover (23) are respectively provided with an air inlet nozzle (24) and an air outlet nozzle (25), and the air inlet nozzle (24) and the air outlet nozzle (25) are communicated with the main air chamber (2) and the auxiliary air chamber (3) in a gas phase mode.
5. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 2, wherein: the first ring groove (1903) is respectively arranged at the inner edges of the side surfaces of the first fixed mirror frame (1901) and the first compression mirror frame (1907), a first limit ring (1904) is embedded in the first ring groove (1903), and the first limit ring (1904) is respectively arranged on the outer circumferences of the main collimation plano-concave lens (12), the auxiliary detection plano-concave lens (17) and the optical filter (18).
6. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 2, wherein: the locking screw holes (1905) are respectively arranged at four sides of the first fixed spectacle frame (1901) and the first pressing spectacle frame (1907) and at four sides, the top end and the bottom end of the second fixed spectacle frame (1902) and the second pressing spectacle frame (1910), and locking screws (1906) are embedded in the locking screw holes (1905).
7. The portable instrument for detecting total reserve function of liver based on infrared light absorption according to claim 2, wherein: the second ring groove (1908) is respectively arranged at the inner edges of the side surfaces of the second fixed mirror frame (1902) and the second compression mirror frame (1910), a second limit ring (1909) is embedded in the second ring groove (1908), and the second limit ring (1909) is respectively arranged on the outer circumferences of the main reference plano-concave lens (13), the main detection plano-concave lens (14), the auxiliary reference plano-concave lens (16) and the auxiliary detection plano-concave lens (17).
8. The portable liver overall reserve function detection method based on infrared light absorption comprises the following steps of firstly, zero point calibration; step two, blank test; step three, oral test; step four, judging the state; the method is characterized in that:
in the first step, a power supply is switched on, after the detector is preheated for 30 minutes, ambient air is respectively introduced into the main air chamber (2) and the auxiliary air chamber (3) through an air inlet nozzle (24) on the box cover (23), black body infrared light emitted by the main black body infrared light source (4) is refracted into black body infrared parallel light through the main collimating plano-concave lens (12), the ambient air in the main air chamber (2) is irradiated, and then the black body infrared parallel light is refracted and focused through the main reference plano-concave lens (13) and the main detection plano-concave lens (14) and is respectively irradiated on the main reference channel (8) and the main detection channel (9), so that optical signals are converted into electric signals, and further voltage signals are transmitted to an upper computer through the main infrared light sensor (6), and CO of the ambient air is obtained2The total concentration, the black body infrared light emitted by the auxiliary black body infrared light source (5) is refracted into black body infrared parallel light by the auxiliary collimating plano-concave lens (15) to irradiate the ambient air in the auxiliary air chamber (3), and the black body infrared parallel light is blocked by the optical filter (18)13CO2After light absorption in the wavelength band, make12CO2The absorption light wave band is refracted and focused by a secondary reference plano-concave lens (16) and a secondary detection plano-concave lens (17) and then respectively irradiated on secondary parametersOn the examination passage (10) and the auxiliary detection passage (11), the optical signal is converted into an electric signal, and then the voltage signal is transmitted to an upper computer through the auxiliary infrared light sensor (7) to obtain the ambient air12CO2Concentration, and finally passing CO through the upper computer2Total concentration of12CO2Difference of concentration, calculating ambient air13CO2The abundance is calibrated at zero point to obtain a zero point sample, and the ambient air is exhausted through an air outlet nozzle (25) on the box cover (23);
in the second step, after the testee fasts and forbids water for eight hours, the exhaled gas of the human body is respectively introduced into the main air chamber (2) and the auxiliary air chamber (3) through the air inlet nozzle (24) on the box cover (23) for four to eight seconds, and then the process in the first step is carried out to obtain the exhaled gas of the human body13CO2Abundance, and as a blank specimen;
in the third step, 75mg of 13C-pyrimethacin is fully dissolved in 100ml of warm boiled water, 30 minutes, 60 minutes and 120 minutes after the tested person takes the medicine orally are respectively introduced into the main air chamber (2) and the auxiliary air chamber (3) through the air inlet nozzle (24) on the box cover (23) to take the exhaled gas orally, and then 30 minutes, 60 minutes and 120 minutes of the exhaled gas orally taken by the human body are obtained through the flow in the first step13CO2Abundance, and as a test specimen;
in the fourth step, the upper computer respectively draws a DOB curve, a metabolic rate curve and an accumulated abundance curve by using the zero point sample obtained in the first step and the blank sample and the test sample obtained in the second step, further respectively calculates DOB values of 30 minutes, 60 minutes and 120 minutes, and further respectively calculates exhaled breath values of 30 minutes, 60 minutes and 120 minutes13CO2Abundance being the total exhale amount13CO2Percent abundance, obtained at 30 min, 60 min and 120 min13CO2The exhalation rate, and thus the cumulative exhalation before 30 minutes, 60 minutes, and 120 minutes as a percentage of the total amount expected to be exhaled, is calculated to yield cumulative exhalations before 30 minutes, 60 minutes, and 120 minutes13CO2Sum of abundances, calculated for 120 minutes13CO2Cumulative exhaled abundance versus normalityThe Cum120 value, namely the hepatocyte compensation index, is obtained by the ratio of the values, and the hepatocyte compensation function state of the tested person is judged.
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