CN113633290A - Method, apparatus, electronic device and readable storage medium for blood perfusion monitoring - Google Patents

Method, apparatus, electronic device and readable storage medium for blood perfusion monitoring Download PDF

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CN113633290A
CN113633290A CN202110948495.0A CN202110948495A CN113633290A CN 113633290 A CN113633290 A CN 113633290A CN 202110948495 A CN202110948495 A CN 202110948495A CN 113633290 A CN113633290 A CN 113633290A
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CN113633290B (en
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樊瑜波
贺欧阳
王碧天
李儒雅
王亚伟
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Beihang University
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    • A61B5/316—Modalities, i.e. specific diagnostic methods
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
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    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
    • A61B5/349—Detecting specific parameters of the electrocardiograph cycle
    • A61B5/36—Detecting PQ interval, PR interval or QT interval

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Abstract

The application relates to the technical field of detection, and discloses a method, a device, an electronic device and a readable storage medium for monitoring blood perfusion, wherein the method comprises the following steps: carrying out electrocardio monitoring on the target person to obtain electrocardiosignals of the target person, carrying out pulse monitoring aiming at the appointed monitoring position of the target person to obtain pulse signals of the target person, then determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring, and further determining the target blood flow of the appointed monitoring position of the target person in the heartbeat cycle according to the pulse signals in the heartbeat cycle. In this way, monitoring of the perfusion of the blood flow can be performed in real time for the person performing the external compression intervention.

Description

Method, apparatus, electronic device and readable storage medium for blood perfusion monitoring
Technical Field
The present application relates to the field of detection technologies, and in particular, to a method, an apparatus, an electronic device, and a readable storage medium for monitoring blood perfusion.
Background
The blood perfusion is the amount of blood flowing into an organ in unit time, is an important index for measuring the processes of tissue healing, microcirculation, metabolism and the like of the organ, and has important application value in the fields of health monitoring, mental state assessment, surgical nursing and the like.
In the prior art, the monitoring of blood perfusion is mainly carried out by adopting photoelectric volume pulse wave and laser speckle imaging.
However, since both the photoplethysmography and the laser speckle imaging can only be used for monitoring the blood perfusion in a static state of the user, they cannot be used for monitoring the blood perfusion in real time when performing external pressure intervention such as external counterpulsation therapy or intermittent pneumatic pressure therapy on the human body.
Therefore, how to monitor the blood perfusion of the user in real time when the external pressure intervention treatment is carried out on the user is a problem to be solved.
Disclosure of Invention
The embodiment of the application provides a blood perfusion monitoring method, a blood perfusion monitoring device, an electronic device and a readable storage medium, which are used for monitoring blood perfusion of a user in real time when external pressure intervention treatment is carried out on the user.
In a first aspect, an embodiment of the present application provides a method for monitoring blood perfusion, the method including:
and carrying out electrocardio monitoring on the target person to obtain an electrocardio signal of the target person, wherein the target person is a person subjected to external pressure intervention.
And pulse monitoring is carried out aiming at the appointed monitoring position of the target person, and a pulse signal of the target person is obtained.
And determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring.
And determining the target blood flow of the appointed monitoring position of the target person in the heartbeat period according to the pulse signals in the heartbeat period.
In the implementation process, when the target person is subjected to external pressure intervention, the electrocardio-monitoring and the pulse-monitoring are carried out, so that an electrocardiosignal and a pulse signal are obtained, further, the heartbeat period of the target person is determined according to the electrocardiosignal, the heartbeat period is determined according to the pulse signal in the heartbeat period, the target blood flow at the appointed monitoring position in the heartbeat period of the target person is determined, and therefore the blood flow perfusion of the target person at the appointed monitoring position can be monitored in real time.
With reference to the first aspect, in one embodiment, determining a target blood flow of a specified monitoring position of a target person in a heartbeat cycle according to pulse signals in the heartbeat cycle includes:
the maximum pulse signal and the minimum pulse signal within a heartbeat period are determined.
A pulse signal difference between the maximum pulse signal and the minimum pulse signal is determined.
And determining the pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference.
The pressurized blood flow is determined as the target blood flow.
In the implementation process, the pulse signal difference between the maximum pulse signal and the minimum pulse signal is determined according to the pulse signals, and then the target blood flow is determined according to the mapping relation between the pulse signal difference and the pressurized blood flow, so that the blood perfusion of the target person is monitored.
With reference to the first aspect, in one embodiment, determining a target blood flow of a specified monitoring position of a target person in a heartbeat cycle according to pulse signals in the heartbeat cycle includes:
obtaining a set blood flow, wherein the set blood flow is determined according to the blood flow of the target person when the target person is not intervened by external pressurization.
A difference in blood flow between the pressurized blood flow and the set blood flow is determined.
And determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
In the implementation process, the pressurized blood flow is adjusted by setting the blood flow, and the adjusted blood flow is used as the target blood flow, so that errors caused by different monitoring positions and different attaching modes of the sensors can be effectively reduced, and the monitoring accuracy of blood perfusion at the specified monitoring position is further improved.
With reference to the first aspect, in one embodiment, the method further includes:
at least one target blood flow of the target person over a preset time period is determined.
And if a plurality of target blood flow volumes are determined, obtaining a target evaluation value according to the average value of the target blood flow volumes.
And if only one target blood flow is determined, obtaining a target evaluation value according to the determined target blood flow.
Wherein the target assessment value is indicative of a therapeutic effect of the external compression intervention on the target person over a preset time period.
In the implementation process, the blood perfusion monitoring is carried out on the target person within the preset time period, so that a plurality of target blood flow volumes within the preset time period are obtained, the average value of the plurality of target blood flow volumes is calculated, and a target evaluation value is obtained, so that the effect of external pressurization intervention treatment within the preset time period can be conveniently evaluated according to the target evaluation value.
With reference to the first aspect, in one embodiment, the method further includes:
if at least two designated monitoring positions are set, the blood flow volume of each designated monitoring position is acquired.
And adjusting the positions of external pressurization intervention or pressurization parameters according to the blood flow volume of each designated monitoring position so as to adjust the blood flow volume of each designated monitoring position.
In the implementation process, blood flow perfusion monitoring is performed on a plurality of designated monitoring positions of a target person, so that blood flow of each designated monitoring position is obtained, and the positions of external pressurization intervention or pressurization parameters are conveniently adjusted according to the distribution condition of the blood flow of each designated monitoring position so as to adjust the blood flow of each designated monitoring position.
In a second aspect, an embodiment of the present application provides an apparatus for monitoring blood perfusion, the apparatus including:
the electrocardio monitoring module is used for carrying out electrocardio monitoring on the target personnel to obtain electrocardio signals of the target personnel, wherein the target personnel are personnel subjected to external pressurization intervention.
And the pulse monitoring module is used for monitoring the pulse aiming at the appointed monitoring position of the target person to obtain the pulse signal of the target person.
And the first determining module is used for determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring.
And the second determination module is used for determining the target blood flow of the appointed monitoring position of the target person in the heartbeat period according to the pulse signals in the heartbeat period.
With reference to the second aspect, in an embodiment, the second determining module is specifically configured to:
the maximum pulse signal and the minimum pulse signal within a heartbeat period are determined.
A pulse signal difference between the maximum pulse signal and the minimum pulse signal is determined.
And determining the pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference.
The pressurized blood flow is determined as the target blood flow.
With reference to the second aspect, in an embodiment, the second determining module is specifically configured to:
obtaining a set blood flow, wherein the set blood flow is determined according to the blood flow of the target person when the target person is not intervened by external pressurization.
A difference in blood flow between the pressurized blood flow and the set blood flow is determined.
And determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
With reference to the second aspect, in one embodiment, the second determining module is further configured to:
at least one target blood flow of the target person over a preset time period is determined.
And if a plurality of target blood flow volumes are determined, obtaining a target evaluation value according to the average value of the target blood flow volumes.
And if only one target blood flow is determined, obtaining a target evaluation value according to the determined target blood flow.
Wherein the target assessment value is indicative of a therapeutic effect of the external compression intervention on the target person over a preset time period.
With reference to the second aspect, in one embodiment, the second determining module is further configured to:
if at least two designated monitoring positions are set, the blood flow volume of each designated monitoring position is acquired.
And adjusting the positions of external pressurization intervention or pressurization parameters according to the blood flow volume of each designated monitoring position so as to adjust the blood flow volume of each designated monitoring position.
In a third aspect, an embodiment of the present application provides an electronic device, including:
the system comprises a processor, a memory and a bus, wherein the processor is connected with the memory through the bus, and the memory stores readable instructions which are used for realizing the method provided by any one of the implementation modes of the first aspect when being executed by the processor.
In a fourth aspect, the present application provides a readable storage medium, on which a program is stored, where the program, when executed by a processor, performs the steps in the method provided in any of the embodiments of the first aspect.
Additional features and advantages of the present application will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by the practice of the embodiments of the present application. The objectives and other advantages of the application may be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments of the present application will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and that those skilled in the art can also obtain other related drawings based on the drawings without inventive efforts.
Fig. 1 is a flow chart of a method for monitoring blood perfusion according to an embodiment of the present disclosure;
FIG. 2 is a schematic diagram illustrating the propagation of light in human tissue in the absence of pulsating blood according to an embodiment of the present disclosure;
FIG. 3 is a schematic diagram illustrating the propagation of light in the presence of pulsating blood in human tissue according to an embodiment of the present disclosure;
FIG. 4 is a block diagram of a pressurized interventional therapy system according to an embodiment of the present application;
fig. 5 is a schematic structural diagram of a pulse monitoring module according to an embodiment of the present disclosure;
fig. 6 is a diagram illustrating an application scenario of a pressurized intervention therapy system according to an embodiment of the present application;
FIG. 7 is a schematic diagram of an ECG signal and a pulse signal according to an embodiment of the present application;
FIG. 8 is a schematic diagram of pulse signals output in a resting state and an IPC active state according to an embodiment of the present disclosure;
fig. 9 is a block diagram of a blood perfusion monitoring apparatus according to an embodiment of the present disclosure;
fig. 10 is a schematic structural diagram of an electronic device according to an embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present application without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures. Meanwhile, in the description of the present application, the terms "first", "second", and the like are used only for distinguishing the description, and are not to be construed as indicating or implying relative importance.
First, some terms referred to in the embodiments of the present application will be described to facilitate understanding by those skilled in the art.
The terminal equipment: may be a mobile terminal, a fixed terminal, or a portable terminal such as a mobile handset, station, unit, device, multimedia computer, multimedia tablet, internet node, communicator, desktop computer, laptop computer, notebook computer, netbook computer, tablet computer, personal communication system device, personal navigation device, personal digital assistant, audio/video player, digital camera/camcorder, positioning device, television receiver, radio broadcast receiver, electronic book device, gaming device, or any combination thereof, including the accessories and peripherals of these devices, or any combination thereof. It is also contemplated that the terminal device can support any type of interface to the user (e.g., wearable device), and the like.
A server: the cloud server can be an independent physical server, a server cluster or a distributed system formed by a plurality of physical servers, and can also be a cloud server for providing basic cloud computing services such as cloud service, a cloud database, cloud computing, cloud functions, cloud storage, network service, cloud communication, middleware service, domain name service, security service, big data and artificial intelligence platform and the like.
The existing blood perfusion monitoring technology mainly comprises a fluorescence imaging technology, a photoplethysmography, a laser speckle imaging technology and the like, wherein the fluorescence imaging technology needs fluorescent substances in blood vessels, and physiological and psychological wounds are easily caused to patients by injecting the fluorescent substances into the blood vessels of the patients.
Accordingly, the present application provides methods, apparatus, electronic devices and readable storage media for monitoring perfusion changes in real time during external compression intervention on a human body.
In the embodiment of the present application, an execution main body of the method may be an electronic device, and optionally, the electronic device may be a server, a terminal device, or a single chip, but the present application is not limited thereto.
Referring to fig. 1, fig. 1 is a flowchart of a method for monitoring blood perfusion according to an embodiment of the present disclosure, wherein the method shown in fig. 1 is implemented as follows:
step 101: and carrying out electrocardio monitoring on the target person to obtain an electrocardiosignal of the target person.
Specifically, medical personnel adopt external pressurization intervention treatment equipment to carry out external pressurization intervention treatment such as external counterpulsation treatment or intermittent pneumatic pressurization treatment on one or more specified monitoring positions of target personnel. The electronic equipment monitors the electrocardiosignals of the target person in real time through the electrocardio monitoring equipment to obtain the electrocardiosignals of the target person.
Wherein the target person is a person who is intervened by external pressurization.
Generally, when a visible light beam penetrates through human skin and interacts with human tissue (e.g., muscle, vascular network, blood, tissue fluid, etc.) under the skin, reflection, absorption, refraction, scattering, etc. can occur, and the propagation law of light in human tissue can be simplified as shown in fig. 2 and 3, fig. 2 is a schematic diagram of the propagation law of light in human tissue without pulsating blood provided by the embodiment of the present application, fig. 3 is a schematic diagram of the propagation law of light in human tissue with pulsating blood provided by the embodiment of the present application, wherein b1 represents tissue layers of skin and muscle in human tissue, b2 represents non-pulsating blood layer in human tissue, Δ b represents pulsating blood layer in human tissue, b3 represents deep tissue layers in human tissue, as shown in fig. 2 and 3, skin and muscle tissue layers of light in human tissue, Reflections occur in both the blood layer and the deep tissue layers.
In general, the content of non-blood components such as skin and muscle tissue remains relatively stable, so when a human body has periodic pulsation in the heart, the influence of reflection of light by the skin and muscle tissue layers is negligible, while in the blood layer, the blood volume has periodic change due to the heart pulsation, so that the absorption of light by the blood layer tissue has periodic change, and when the light intensity returned to the outside of the body is monitored by a light detector, a pulse signal, namely a PhotoPlethysmoGraphy (PPG) signal, can be obtained.
Specifically, the light intensity monitored by the light detector follows the following law:
when monochromatic light irradiates a certain solution to be transmitted, the transmitted light intensity and the incident light intensity follow the Lambert-beer law:
I1＝I01e-κbc (1)
wherein, I1Represents the transmitted light intensity, I01Denotes the incident light intensity,. kappa.molar absorbance, b solution thickness, c solution concentration.
When monochromatic light irradiates a certain solution to be reflected, the reflected light intensity and the scattered light intensity can be expressed by the formula (2):
I2＝p*I02(2)
wherein, I2Represents the intensity of reflected light, I02Indicating the intensity of the scattered light and p is the reflectance.
In general, the skin and muscle layers, the non-pulsating blood layer and the deep tissue layer are relatively unchanged, so the reflected light, scattered light and absorbed light of these tissues are relatively unchanged, the blood concentration is an average value of one heartbeat cycle and is constant in a period of time, so that the light intensity monitored by the light detector can be represented by formula (3) according to the propagation law of human body to light in fig. 2 and 3:
I＝A+Be-Δb (3)
where a represents the intensity of reflected light and scattered light of tissue layers such as skin and muscle, B represents the light absorption constant of skin muscle other than pulsating blood, non-pulsating blood, deep tissue, and the like, and Δ B represents the pulsating blood layer in human tissue.
As an example, the maximum value I of the pulse signal monitored by the optical detector in a heartbeat cyclemaxCorresponding Δ b is 0, minimum value IminThe corresponding Δ b is taken to be the maximum, the minimum is subtracted from the maximum value of the pulse signal and taylor expansion is performed, as shown in equation (4):
Figure BDA0003217733750000091
further, equation (4) is processed in order to determine the pulsating blood layer Δ b in the human tissue. Specifically, if the high-order term in the formula (4) is ignored and the first-order term is retained, the formula (5) can be obtained:
Imax-Imin≈BΔb (5)
wherein B represents the light absorption constant of skin muscle, non-pulsating blood, deep tissue, etc. other than pulsating blood, and therefore, the pulsating blood layer Δ B and the pulse signal maximum value ImaxAnd the minimum value I of pulse signalminThe difference in (a) is positively correlated.
Typically, the change in pulsatile blood volume Δ V is positively correlated to Δ b during a heartbeat cycle.
Thus, the change in the volume of pulsatile blood Δ V during a heartbeat cycle is related to the pulse signal monitored by the photodetector as shown in equation (6):
ΔV∝(Imax-Imin) (6)
that is, the change Δ V of the pulsating blood volume is positively correlated with the difference between the maximum value and the minimum value of the pulse signal monitored by the photodetector.
As shown in fig. 4, fig. 4 is a structural diagram of a pressurized intervention treatment system provided by an embodiment of the present application, and the pressurized intervention treatment system 400 shown in fig. 4 includes: the electrocardiogram monitoring module 410, the pulse monitoring module 420, the transmission module 430, the processing module 440 and the display module 450, wherein the electrocardiogram monitoring module 410 includes an electrocardiogram acquisition circuit 411 and an electrocardiogram sensor 412, the pulse monitoring module 420 includes a pulse acquisition circuit 421 and a pulse sensor 422, and the pulse sensor 422 includes a light source 4221 and a light detector 4222.
As an embodiment, a structure of the pulse monitoring module is as shown in fig. 5, and fig. 5 is a schematic structural view of the pulse monitoring module provided in the embodiment of the present application, in an implementation, the pulse monitoring module is a pulse sensor 422, a light source 4221 and a light detector 4222 included in the pulse sensor 422 are both attached to a skin surface of a human body, and the pulse sensor 422 is electrically connected to the pulse acquisition circuit 421.
It should be noted that, in the present application, only the light source 4221 and the light detector 4222 are located on the same side of the light path for example, that is, the light source 4221 and the light detector 4222 are attached to the skin surface, and then the signal received by the light detector 4222 is a reflected light intensity signal, in the practical application process, the light source 4221 and the light detector 4222 may also be located on different sides of the light path, for example, the pulse sensor 422 is clamped at a thinner position of human tissue such as a limb end or an earlobe, that is, the light detector 4222 receives light transmitted by the light source 4221 through the human tissue, and then the signal received by the light detector 4222 is a transmitted light intensity signal.
It should be noted that, the present application only takes the relationship between the reflected light intensity and the change Δ V of the pulsating blood volume as an example, and in the practical application process, the relationship between the transmitted light intensity and the change Δ V of the pulsating blood volume also follows the rule of the above formula (6).
The Light source 4221 may be a Light Emitting Diode (LED), an Organic Light Emitting semiconductor (OLED), or another Light source, but the present application is not limited thereto, and the pulse acquisition Circuit 421 may be made of a rigid Circuit Board (PCB) or a flexible PCB, but the present application is not limited thereto.
As an example, the pulse sensor 422 is made as a flexible device in order to make the pulse sensor 422 better fit to the skin.
Further, fig. 6 is an application scenario diagram of a pressurized intervention treatment system provided in an embodiment of the present application, and the pressurized intervention treatment is performed on the target person in fig. 6, where the pressurized intervention treatment device is an intermittent compression (IPC) airbag 600, the IPC airbag 600 is disposed in the middle of the lower leg of the target person, the electrocardiograph acquisition mode uses a limb lead, the electrocardiograph sensors 412 are attached to the left wrist and the right wrist, and the pulse sensors 422 are attached to the skin of the right leg, and in some embodiments, one or more pulse sensors 422 may be used, as shown in fig. 6, 3 pulse sensors 422 are used, and are respectively located at 2cm above the IPC airbag 600, 2cm below the IPC airbag 600, and at the instep. The electrocardiosignal 411 and the pulse signal are collected by the pulse collecting circuit 421 and transmitted to the processing module 440 through the transmission module 430, the processing module 440 performs signal preprocessing and extracts blood perfusion characteristic parameters, so as to obtain blood flow, further, the preprocessed electrocardiosignal and pulse signal are displayed through the display module 450, and the display module 450 can also display the blood flow obtained through the processing module.
Generally, when the IPC pressurizing balloon 600 is pressurized, a drastic change in the blood volume of the nearby skin tissue is usually caused, which is reflected as a change in the pulsating blood component, but the change in the non-pulsating blood component, i.e., the low-frequency component, is small and negligible.
In one embodiment, step 101 is executed, when the IPC pressurizing airbag 600 performs the pressurizing intervention treatment, the target person is monitored by electrocardiography, and the electrocardiographic signal acquired by the electrocardiography sensor 412 is transmitted to the electrocardiography acquisition circuit 411, so as to acquire the electrocardiographic signal of the target person.
Step 102: and pulse monitoring is carried out aiming at the appointed monitoring position of the target person, and a pulse signal of the target person is obtained.
Specifically, medical personnel carry out the pulse monitoring to target person's appointed monitoring position, and electronic equipment passes through pulse sensor 422 and transmits the pulse signal of gathering to pulse acquisition circuit 421 to obtain target person's pulse signal.
It should be noted that the specified monitoring position refers to a body position of a target person to which the pulse sensor 422 is attached, in this embodiment, only the specified monitoring position is located at 2cm of the upper end of the IPC pressurizing air bag 600, 2cm of the lower end of the IPC pressurizing air bag 600, and a instep as an example.
Step 103: and determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring.
Specifically, the heartbeat cycle of the target person during IPC compression therapy is determined according to the electrocardiographic signal of the target person acquired by the electrocardiographic acquisition circuit 411.
In an embodiment, before determining the heartbeat cycle of the target person according to the electrocardiographic signals obtained by monitoring, the electrocardiographic signals obtained by the electrocardiographic acquisition circuit 411 and the pulse signals obtained by the pulse acquisition circuit 421 are preprocessed to obtain preprocessed electrocardiographic signals and pulse signals.
It should be noted that the preprocessing process may include at least one of low-pass filtering and smoothing filtering, and may also include other preprocessing processes, and the application is not limited thereto.
As an embodiment, fig. 7 is a schematic diagram of an electrocardiographic signal and a pulse signal according to an embodiment of the present application, as shown in fig. 7, an abscissa represents time, and an ordinate represents a voltage amplitude of an output of the electrocardiographic signal or the pulse signal, and a heartbeat cycle of a target person is determined according to the output electrocardiographic signal.
As shown in fig. 7, the interval time between two consecutive peaks of the R-wave signal of the output electrocardiographic signal is defined as the heart cycle of the target person, i.e., Δ T in fig. 7 represents the heart cycle of the target person.
It should be noted that, in the embodiment of the present application, only the interval time between two consecutive peaks of the R-wave signal is taken as the heartbeat cycle of the target person for description, in practical applications, the interval time between two consecutive troughs of the R-wave signal may also be taken as the heartbeat cycle of the target person, and the heartbeat cycle of the target person may also be determined in other manners, which is not limited to this application.
In addition, in the embodiment of the present application, the heartbeat cycle of the target person is determined only by the R wave signal of the electrocardiograph signal, and in the practical application process, the heartbeat cycle of the target person may also be determined by the P wave, the Q wave, the S wave or the T wave of the electrocardiograph signal, which is not limited thereto.
Step 104: and determining the target blood flow of the appointed monitoring position of the target person in the heartbeat period according to the pulse signals in the heartbeat period.
Specifically, before determining the pulse signal in the heartbeat period, the time difference between the transmission of the electrocardiosignal and the pulse signal is obtained.
In one embodiment, since it takes a certain time for blood to flow from the heart to another part, the pulse signal is delayed from the electrocardiographic signal, and therefore, it is necessary to obtain a time difference between the transmission of the electrocardiographic signal and the transmission of the pulse signal before the pulse signal in the same heartbeat cycle is determined.
Specifically, the time difference between the transmission of the electrocardiographic signal and the pulse signal can be obtained in the following manner: when the target person is at rest, that is, when no IPC pressure is applied, the electrocardiographic signal and the pulse signal are monitored, the average delay time of the electrocardiographic signal and the pulse signal is calculated, and the average delay time is used as the difference between the transmission intervals of the electrocardiographic signal and the pulse signal, that is, Δ t in fig. 7 represents the difference between the transmission intervals of the electrocardiographic signal and the pulse signal.
Further, according to the interval time difference delta t between the transmission of the electrocardiosignals and the pulse signals and the heartbeat period of the target person, the pulse signals in the same heartbeat period with the electrocardiosignals are determined.
Specifically, as shown in fig. 7, the time corresponding to the first peak of the electrocardiographic signal is taken as the start time, and the interval time difference between the electrocardiographic signal and the pulse signal is increased based on the start time, so as to obtain the time of the start point corresponding to the pulse signal in the same heartbeat cycle, and further increase the time of the heartbeat cycle according to the time of the start point, so as to obtain the time of the end point corresponding to the pulse signal in the same heartbeat cycle, and obtain the pulse signal in the time range from the time of the start point to the end point, where the pulse signal in the time period is the pulse signal in the same heartbeat cycle as the electrocardiographic signal.
In the implementation process, the pulse signal in the same heartbeat cycle as the electrocardiosignal is determined according to the interval time difference between the transmission of the electrocardiosignal and the pulse signal and the heartbeat cycle of the target person, so that the time difference generated by the time for blood to flow in different body parts of the target person can be effectively reduced, the error of the obtained pulse signal is further reduced, and the accuracy of blood flow monitoring is improved.
As an example, in performing step 104, the following steps may be taken:
the first step is as follows: the maximum pulse signal and the minimum pulse signal within a heartbeat period are determined.
Specifically, pulse signals in the heartbeat period are obtained, and the maximum pulse signal and the minimum pulse signal in the pulse signals are determined.
The second step is that: a pulse signal difference between the maximum pulse signal and the minimum pulse signal is determined.
The third step: and determining the pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference.
The fourth step: the pressurized blood flow is determined as the target blood flow.
As an example, according to equation (6), the pulse signal difference is positively correlated with the pressurized blood flow, i.e., the pulse signal difference is determined as the pressurized blood flow, and the pressurized blood flow is the final target blood flow.
In the implementation process, the pulse signal difference between the maximum pulse signal and the minimum pulse signal is determined according to the pulse signals, and then the target blood flow is determined according to the mapping relation between the pulse signal difference and the pressurized blood flow, so that the blood perfusion of the target person is monitored.
As another example, when step 104 is executed, the target blood flow may be obtained by normalizing the pressurized blood flow according to the set blood flow, and specifically, the following steps may be adopted to normalize the pressurized blood flow according to the set blood flow:
the method comprises the following steps: obtaining a set blood flow, wherein the set blood flow is determined according to the blood flow of the target person when the target person is not intervened by external pressurization.
Specifically, the electrocardiosignal and the corresponding pulse signal of the target person in a rest state within a period of time are determined, and the average value of the blood flow of the target person corresponding to a plurality of heartbeat cycles within the period of time is determined according to the above mode, and the average value is the set blood flow.
Here, the period of time may be 30 minutes, 40 minutes, or 60 minutes, but the present invention is not limited thereto.
Step two: a difference in blood flow between the pressurized blood flow and the set blood flow is determined.
Specifically, the difference in blood flow between the pressurized blood flow and the set blood flow in the IPC pressurized state of the target person is determined in the above process.
Step three: and determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
Specifically, the target blood flow is determined according to the relative change rate between the pressurized blood flow and the set blood flow, namely, the target blood flow is determined according to the ratio of the blood flow difference to the set blood flow.
As an example, blood flow is set to V1Pressurized blood flow volume of V2When the difference between the pressurized blood flow and the set blood flow is Δ V ═ V2-V1。
Further, the relative rate of change between the pressurized blood flow and the set blood flow is
Figure BDA0003217733750000151
Further, the target blood flow rate is reflected by the relative change rate n between the pressurized blood flow rate and the set blood flow rate, that is, a larger relative change rate n between the pressurized blood flow rate and the set blood flow rate indicates a larger target blood flow rate, and a smaller relative change rate n between the pressurized blood flow rate and the set blood flow rate indicates a smaller target blood flow rate.
In the implementation process, the pressurized blood flow is normalized according to the set blood flow to obtain the target blood flow, and the blood perfusion of the specified monitoring position is reflected by the target blood flow obtained after normalization, so that errors caused by different attaching modes of the monitoring position and each sensor can be effectively reduced, and the monitoring accuracy of the blood perfusion of the specified monitoring position is further improved.
As shown in fig. 8, fig. 8 is a schematic diagram of pulse signals output in a resting state and an IPC active state according to an embodiment of the present application, in fig. 8, a change of a waveform of the pulse signal output in the resting state is relatively smooth, and a fluctuation range of a waveform of the pulse signal output in the IPC active state is relatively large.
Further, in order to monitor the treatment effect of the IPC compression treatment process in real time, the method of the present application may further include the following steps:
first, at least one target blood flow of a target person over a preset time period is determined.
And if a plurality of target blood flow volumes are determined, obtaining a target evaluation value according to the average value of the target blood flow volumes.
And if only one target blood flow is determined, obtaining a target evaluation value according to the determined target blood flow.
Wherein the target assessment value is indicative of a therapeutic effect of the external compression intervention on the target person over a preset time period.
Specifically, the target blood flow of the target person at the designated monitoring position within the preset time period is determined through the methods of the above steps 101 to 104.
It should be noted that, in the above process, each heartbeat cycle corresponds to one target blood flow at each designated monitoring position, that is, a preset time period corresponds to at least one heartbeat cycle of the target person, and corresponds to at least one target blood flow.
As an example, if a plurality of target blood flow amounts are determined, an average value of the target blood flow amounts is calculated, and the average value of the target blood flow amounts is determined as a target evaluation value.
As an example, if only one target blood flow is determined, the determined one target blood flow is used as a target evaluation value.
Further, the observer may evaluate the overall effect of IPC compression therapy on blood perfusion of the target person at the specified monitoring location within the preset time period according to the target evaluation value, i.e. the larger the target evaluation value is, the larger the mean blood perfusion of the specified monitoring location within the preset time period is, the smaller the target evaluation value is, and the smaller the mean blood perfusion of the specified monitoring location within the preset time period is.
As an embodiment, a target evaluation value is obtained according to each target blood flow variance of a target person within a preset time period, IPC compression treatment is evaluated within the preset time period according to the target evaluation value, a fluctuation range of the blood flow at a specified monitoring position, and the intensity of the change of the blood flow at the specified monitoring position are specified. That is, the larger the target evaluation value is, the larger the fluctuation range of the blood flow volume at the specified monitoring position within the preset time period is, that is, the more drastic the blood flow volume at the specified monitoring position is; the smaller the target evaluation value is, the smaller the fluctuation range of the blood flow at the designated monitoring position is, that is, the gentler the blood flow change at the designated monitoring position is, indicating that the IPC compression treatment is in the preset time period.
In the implementation process, the blood perfusion of the target person who carries out the IPC compression treatment is monitored in a preset time period, the average value of the blood flow in the preset time period is obtained, and the influence of the whole process of the IPC treatment on the blood perfusion can be evaluated according to the average value of the blood flow.
In addition, blood perfusion monitoring is performed at a plurality of positions of a target person, and an IPC pressurizing device can be adjusted so that blood flows at the target position according to the distribution of blood flow.
As an embodiment, if there are at least two designated monitoring positions, the blood flow of each designated monitoring position is obtained according to the method of the above steps 101 to 104.
By monitoring the blood perfusion at a plurality of appointed monitoring positions of the target person, the blood flow of each appointed monitoring position can be obtained, namely the blood perfusion distribution condition of the target person is obtained.
Further, the position of the external compression intervention or the compression parameter is adjusted according to the blood flow volume at each designated monitoring position to adjust the blood flow volume at each designated monitoring position.
Specifically, the position of the external compression intervention or the compression parameter can be adjusted so that the blood flow volume at each designated monitoring position is in an ideal state, based on the blood flow volume at each designated monitoring position.
As an embodiment, as shown in fig. 6, 3 designated monitoring positions are set to be located at 2cm of the upper end of the IPC pressurizing air bag 600, 2cm of the lower end of the IPC pressurizing air bag 600, and the instep, respectively, and blood flow perfusion monitoring is performed on the 3 designated monitoring positions, so as to obtain blood flow at each designated monitoring position, that is, obtain blood perfusion distribution, and determine whether the blood flow at each designated monitoring position reaches an ideal state.
For example, assume that the blood flow at each designated monitoring position is 100 in the resting state, and ideally, the blood flow at 2cm above the IPC pressurizing balloon 600 is 170, the blood flow at 2cm below the IPC pressurizing balloon 600 is 180, and the blood flow at the instep is 170.
In an actual monitoring process, if the blood flow monitored at the 2cm position of the upper end of the IPC pressurizing air bag 600 is 180, the blood flow monitored at the 2cm position of the lower end of the IPC pressurizing air bag 600 is 195, and the blood flow monitored at the instep position is 140, at the moment, the blood flow at each specified monitoring position does not reach an ideal state, the position of the IPC pressurizing air bag 600 or the parameters of the IPC pressurizing air bag 600 can be adjusted, and the blood flow at each specified monitoring position is monitored again, so that the blood flow monitored at the 2cm position of the upper end of the IPC pressurizing air bag 600, the 2cm position of the lower end of the IPC pressurizing air bag 600, and the instep position reaches the ideal state.
It should be noted that, in the present application, only 3 designated monitoring positions at 2cm of the upper end of the IPC pressurizing air bag 600, 2cm of the lower end of the IPC pressurizing air bag 600, and 3 designated monitoring positions at the instep are taken as examples for description, and in the practical application, the designated monitoring positions may be 3 or 4, may be on the same side of the IPC pressurizing air bag, or may be on the opposite side of the IPC pressurizing air bag, but the present application is not limited thereto.
In the implementation process, in the IPC compression treatment process, the blood perfusion distribution of the body of the target person can be determined by monitoring the blood perfusion at a plurality of positions of the body of the target person, and further, the position and the parameters of the IPC compression treatment device are adjusted according to the blood perfusion distribution, so that the blood can accurately flow to the designated position on the body of the target person, and the treatment effect of the IPC compression treatment is improved.
In the implementation process, the electrocardio monitoring and the pulse monitoring are carried out when the target person is subjected to external pressure intervention, so that an electrocardiosignal and a pulse signal are obtained, further, the heartbeat period of the target person is determined according to the electrocardiosignal and determined according to the pulse signal in the heartbeat period, and the target blood flow at the appointed monitoring position in the heartbeat period of the target person is monitored, so that the change condition of blood flow perfusion of the target person at the appointed monitoring position can be monitored in real time when the target person is subjected to external pressure intervention.
Referring to fig. 9, fig. 9 is a block diagram of a blood perfusion monitoring apparatus according to an embodiment of the present disclosure, and the apparatus 900 shown in fig. 9 corresponds to the method of fig. 1, and includes various functional modules capable of implementing the method of fig. 1.
In one embodiment, the apparatus 900 shown in FIG. 9 includes:
the electrocardiogram monitoring module 910 is configured to perform electrocardiogram monitoring on a target person to obtain an electrocardiogram signal of the target person, where the target person is a person subjected to external pressure intervention.
And a pulse monitoring module 920, configured to perform pulse monitoring on the specified monitoring location of the target person to obtain a pulse signal of the target person.
The first determining module 930 is configured to determine a heartbeat cycle of the target person according to the electrocardiographic signal obtained through monitoring.
The second determining module 940 is further configured to determine a target blood flow of the designated monitoring location of the target person in the heartbeat cycle according to the pulse signal in the heartbeat cycle.
In an embodiment, the second determining module 940 is specifically configured to:
determining a maximum pulse signal and a minimum pulse signal in a heartbeat period;
determining a pulse signal difference between the maximum pulse signal and the minimum pulse signal;
determining a pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference;
the pressurized blood flow is determined as the target blood flow.
In an embodiment, the second determining module 940 is specifically configured to:
obtaining a set blood flow, wherein the set blood flow is determined according to the blood flow of the target person when the target person is not intervened by external pressurization;
determining a blood flow difference between the pressurized blood flow and the set blood flow;
and determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
In one embodiment, the second determining module 940 is further configured to:
at least one target blood flow of the target person over a preset time period is determined.
And if a plurality of target blood flow volumes are determined, obtaining a target evaluation value according to the average value of the target blood flow volumes.
And if only one target blood flow is determined, obtaining a target evaluation value according to the determined target blood flow.
Wherein the target assessment value is indicative of a therapeutic effect of the external compression intervention on the target person over a preset time period.
In one embodiment, the second determining module 940 is further configured to:
if at least two designated monitoring positions are set, the blood flow volume of each designated monitoring position is acquired.
And adjusting the positions of external pressurization intervention or pressurization parameters according to the blood flow volume of each designated monitoring position so as to adjust the blood flow volume of each designated monitoring position.
It should be noted that the apparatus 900 shown in fig. 9 can implement the processes of the blood perfusion monitoring method in the embodiment of the method of fig. 1. The operations and/or functions of the various modules in the apparatus 900 are each intended to implement a corresponding flow in the method embodiment in fig. 1. Reference may be made specifically to the description of the above method embodiments, and a detailed description is appropriately omitted herein to avoid redundancy.
Referring to fig. 10, fig. 10 is a schematic structural diagram of an electronic device according to an embodiment of the present disclosure, where the electronic device 110 shown in fig. 10 may include: at least one processor 111, e.g., a CPU, at least one communication interface 112, at least one memory 113 and at least one communication bus 114. Wherein the communication bus 114 is used for realizing direct connection communication of these components. The communication interface 112 of the device in the embodiment of the present application is used for communicating signaling or data with other node devices. The memory 113 may be a high-speed RAM memory or a non-volatile memory (e.g., at least one disk memory). The memory 113 may optionally be at least one storage device located remotely from the aforementioned processor. The memory 113 stores readable instructions, and when the readable instructions are executed by the processor 111, the electronic device executes the method process shown in fig. 1.
An embodiment of the present application provides a readable storage medium, which stores a program, and when the program is executed by a processor, the program implements the method process shown in fig. 1.
In the several embodiments provided in the present application, it should be understood that the disclosed system and method may be implemented in other ways. The above-described system embodiments are merely illustrative, and for example, the division of the system apparatus into only one logical functional division may be implemented in other ways, and for example, a plurality of apparatuses or components may be combined or integrated into another system, or some features may be omitted, or not implemented.
In addition, units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
The above description is only an example of the present application and is not intended to limit the scope of the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims (10)

1. A method of blood perfusion monitoring, the method comprising:
carrying out electrocardio monitoring on a target person to obtain an electrocardio signal of the target person, wherein the target person is a person subjected to external pressure intervention;
pulse monitoring is carried out aiming at the appointed monitoring position of the target person, and a pulse signal of the target person is obtained;
determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring;
and determining the target blood flow of the appointed monitoring position of the target person in the heartbeat period according to the pulse signals in the heartbeat period.
2. The method of claim 1, wherein said determining a target blood flow of the designated monitoring location of the target person over the heartbeat cycle from the pulse signals over the heartbeat cycle comprises:
determining a maximum pulse signal and a minimum pulse signal within the heartbeat period;
determining a pulse signal difference between the maximum pulse signal and the minimum pulse signal;
determining a pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference;
determining the pressurized blood flow as the target blood flow.
3. The method of claim 2, wherein said determining a target blood flow of the designated monitoring location of the target person over the heartbeat cycle from the pulse signals over the heartbeat cycle comprises:
obtaining a set blood flow, wherein the set blood flow is determined from the blood flow of the target person when not being intervened by external pressurization;
determining a blood flow difference between the pressurized blood flow and the set blood flow;
and determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
4. The method according to any one of claims 1-3, further comprising:
determining at least one target blood flow volume of the target person over a preset time period;
if a plurality of target blood flow volumes are determined, obtaining a target evaluation value according to the average value of the target blood flow volumes;
if only one target blood flow is determined, obtaining a target evaluation value according to the determined target blood flow;
wherein the target assessment value characterizes a therapeutic effect of the external compression intervention on the target person over the preset time period.
5. The method according to any one of claims 1-3, further comprising:
if the number of the appointed monitoring positions is at least two, obtaining the blood flow of each appointed monitoring position;
and adjusting the positions of external pressurization intervention or pressurization parameters according to the blood flow of the designated monitoring positions so as to adjust the blood flow of the designated monitoring positions.
6. An apparatus for blood perfusion monitoring, the apparatus comprising:
the electrocardio monitoring module is used for carrying out electrocardio monitoring on a target person to obtain an electrocardio signal of the target person, wherein the target person is a person subjected to external pressure intervention;
the pulse monitoring module is used for carrying out pulse monitoring on the appointed monitoring position of the target person to obtain a pulse signal of the target person;
the first determining module is used for determining the heartbeat cycle of the target person according to the electrocardiosignals obtained by monitoring;
and the second determination module is used for determining the target blood flow of the appointed monitoring position of the target person in the heartbeat period according to the pulse signals in the heartbeat period.
7. The apparatus of claim 6, wherein the second determining module is specifically configured to:
determining a maximum pulse signal and a minimum pulse signal within the heartbeat period;
determining a pulse signal difference between the maximum pulse signal and the minimum pulse signal;
determining a pressurized blood flow according to the pulse signal difference, wherein the pressurized blood flow is positively correlated with the pulse signal difference;
determining the pressurized blood flow as the target blood flow.
8. The apparatus of claim 7, wherein the second determining module is specifically configured to:
obtaining a set blood flow, wherein the set blood flow is determined from the blood flow of the target person when not being intervened by external pressurization;
determining a blood flow difference between the pressurized blood flow and the set blood flow;
and determining the target blood flow according to the ratio of the blood flow difference to the set blood flow.
9. An electronic device, comprising:
a processor, a memory and a bus, the processor being connected to the memory via the bus, the memory storing readable instructions for implementing the method of any one of claims 1-5 when the readable instructions are executed by the processor.
10. A readable storage medium, characterized in that the readable storage medium has stored thereon a program which, when executed by a processor, carries out the method according to any one of claims 1-5.
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