CN113616922A - Target electric field generating device and control method - Google Patents
Target electric field generating device and control method Download PDFInfo
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- CN113616922A CN113616922A CN202110821323.7A CN202110821323A CN113616922A CN 113616922 A CN113616922 A CN 113616922A CN 202110821323 A CN202110821323 A CN 202110821323A CN 113616922 A CN113616922 A CN 113616922A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
Abstract
The embodiment of the application provides a generating device and a control method of a target electric field, wherein the generating device of the target electric field comprises: at least two groups of electrode pairs, an electric signal generating circuit and a control circuit. At least two groups of electrode pairs, which are used for being arranged at the target biological tissue according to a design mode; the electric signal generating circuit is electrically connected with the at least two groups of electrode pairs and is used for outputting electric signals to each group of electrode pairs; and the control circuit is electrically connected with the electric signal generating circuit and the at least two groups of electrode pairs and is used for controlling the electric signals so as to adjust the strength and/or direction of an electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding the target biological tissue. By adopting the method and the device, the target biological tissue area can be comprehensively scanned and covered by the target electric field with the variable direction, and the treatment effect on the target biological tissue is improved.
Description
Technical Field
The application relates to the field of medical treatment, in particular to a target electric field generating device and a control method.
Background
The rapid growth of tumors in general, and malignant tumors in particular, is the result of relatively frequent cell division or proliferation compared to normal tissue cells.
In the existing devices for destroying diseased cells or inhibiting the division of diseased cells, two sets of electrode pairs are generally adopted, electric fields are alternately generated on the two sets of electrode pairs, and some target biological tissue areas may not be covered because the direction of the electric fields is fixed, thereby limiting the treatment effect.
Disclosure of Invention
The application aims at the defects of the prior art and provides a target electric field generating device and a control method, which are used for solving the technical problem that the target biological tissue area is possibly not covered due to the fact that the direction of an electric field is fixed in the prior art.
In a first aspect, an embodiment of the present application provides a device for generating a target electric field, including:
at least two groups of electrode pairs, which are used for being arranged at the target biological tissue according to a design mode;
the electric signal generating circuit is electrically connected with at least two groups of electrode pairs and is used for outputting electric signals to each group of electrode pairs;
and the control circuit is electrically connected with the electric signal generating circuit and the at least two groups of electrode pairs and is used for controlling the electric signals so as to adjust the strength and/or direction of the electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding target biological tissues.
In one possible implementation, the control circuit is further configured to control the phases of the electrical signals output to the electrode pairs of each group, so that the electrical signals received by the electrode pairs of each group have a phase difference.
In one possible implementation manner, the phase difference of the electrical signals received by two adjacent groups of electrode pairs is 360:2n, and n is an integer not less than 2.
In one possible implementation manner, the control circuit is further configured to control the voltage of the electrical signal output to each group of electrode pairs, so that the electric field formed by each group of electrode pairs reaches the designed electric field strength.
In one possible implementation, the generating means of the target electric field further comprises at least one of:
the control circuit is also used for periodically controlling the phase of the electric signal corresponding to each group of electrode pairs, so that the direction of the target electric field changes along the anticlockwise direction or the clockwise direction;
and simultaneously transmitting the electric signals with the adjusted phases and/or intensities to each group of electrode pairs so that each group of electrode pairs simultaneously generate an electric field.
In one possible implementation, the electrical signal generating circuit includes:
an alternating current signal generating circuit for generating an alternating current signal; alternatively, the first and second electrodes may be,
and the pulse electric signal generating circuit is used for generating a pulse electric signal.
In one possible implementation, the at least two sets of electrode pairs include: a first set of electrode pairs and a second set of electrode pairs;
the first group of electrode pairs and the second group of electrode pairs are arranged around the target biological tissue according to the design position;
the control circuit includes: a first control sub-circuit and a second control sub-circuit;
the first control sub-circuit controls the voltage and the phase of the electric signals transmitted to the first group of electrode pairs, so that a first electric field generated by the first group of electrode pairs reaches a first design electric field strength and a first design electric field direction;
the second control sub-circuit controls the voltage and the phase of the electric signals transmitted to the second group of electrode pairs, so that a second electric field generated by the second group of electrode pairs reaches a second design electric field strength and a second design electric field direction.
In one possible implementation, the strength of the first electric field and the strength of the second electric field are both above 0 volts per centimeter and below 10 volts per centimeter;
the direction of the first electric field is vertical to that of the second electric field;
the intensity of the coupled first electric field and the second electric field is more than 2 volts per centimeter
Volts per centimeter or less;
the direction of the electric field after the first electric field and the second electric field are coupled is more than 0 DEG and less than 360 deg.
In a second aspect, an embodiment of the present application provides a method for controlling a target electric field, which is applied to a device for generating the target electric field in the first aspect, and includes:
controlling the electric signals output by the electric signal generating circuit to at least two groups of electrode pairs to adjust the intensity and/or direction of the electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding target biological tissues; the generating device comprises an electric signal generating circuit and at least two groups of electrode pairs which are electrically connected.
In one possible implementation, controlling the electrical signals output by the electrical signal generating circuit to at least two sets of electrode pairs to adjust the strength and/or direction of the electric field of each set of electrode pairs, so that each set of electrode pairs forms a target electric field at least surrounding a target biological tissue, includes:
and controlling the phase of the electric signals output to each group of electrode pairs so that the electric signals received by each group of electrode pairs have phase difference.
In one possible implementation, controlling the electrical signals output by the electrical signal generating circuit to at least two sets of electrode pairs to adjust the strength and/or direction of the electric field of each set of electrode pairs, so that each set of electrode pairs forms a target electric field at least surrounding a target biological tissue, includes:
and controlling the voltage of the electric signal output to each group of electrode pairs, so that the electric field formed by each group of electrode pairs reaches the designed electric field strength.
In one possible implementation, the electrical signals output by the electrical signal generating circuit to at least two sets of electrode pairs are controlled to adjust the strength and/or direction of the electric field of each set of electrode pairs, so that each set of electrode pairs forms a target electric field at least surrounding a target biological tissue, including at least one of:
the phase of the electric signal corresponding to each group of electrode pairs is periodically controlled, so that the direction of the target electric field changes along the anticlockwise direction or the clockwise direction;
and simultaneously transmitting each electric signal after the phase and/or the intensity are adjusted to each group of electrode pairs, so that each group of electrode pairs simultaneously generate an electric field, wherein the electric signals comprise: an alternating current signal or a pulsed electrical signal.
The technical scheme provided by the embodiment of the application at least has the following beneficial effects:
(1) the generation device and the control method for the target electric field provided by the embodiment of the application can control the electric signals output by the electric signal generation circuit to at least two groups of electrode pairs through the control circuit so as to adjust the strength and/or direction of the electric field of each group of electrode pairs, and further obtain electric fields in a plurality of different directions, so that the direction of the target electric field formed by the electric fields in all directions of each group of electrode pairs vectorized can be changed, for example, the target electric field can be a rotating electric field, so that a target biological tissue region can be fully scanned and covered by the target electric field with the changeable direction, and the treatment effect on the target biological tissue is improved.
(2) When the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the degree of pathological cell division to avoid damaging healthy cells.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic diagram of a frame of a device for generating a target electric field according to an embodiment of the present disclosure;
FIG. 2 is a schematic diagram of a frame of another apparatus for generating a target electric field according to an embodiment of the present disclosure;
FIG. 3 is a schematic structural diagram of two sets of electrode pairs simultaneously having electric fields according to an embodiment of the present disclosure;
fig. 4 is a flowchart illustrating a method for controlling a target electric field according to an embodiment of the present disclosure.
Reference numerals:
1-at least two sets of electrode pairs, 11-a first set of electrode pairs, 12-a second set of electrode pairs;
2-an electrical signal generating circuit;
3-control circuit, 31-first control sub-circuit, 32-second control sub-circuit.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
The present inventors have conducted studies to find that, in the existing devices for destroying diseased cells or inhibiting the division of diseased cells, electric fields having an electric field strength in the range of 1V/cm to 10V/cm (volts per centimeter) and an electric field frequency in the range of 50kHz to 500kHz (kilohertz) are generally applied to a target biological tissue region, and that the effect of these electric fields on destroying diseased cells or inhibiting the division of diseased cells is increased when more than one electric field direction is used (for example, when the electric fields are switched between two or three directions in which the electric fields differ from each other by about 90 °). These alternating electric fields are referred to herein as Tumor treatment fields (Tumor Treating fields) or TT fields. The TT field is capable of preventing proliferation and destruction of rapidly proliferating viable cells (e.g., cancer cells).
In the existing devices for destroying diseased cells or inhibiting the division of diseased cells, two sets of electrode pairs are generally adopted, electric fields are alternately generated on the two sets of electrode pairs, and some target biological tissue areas may not be covered because the direction of the electric fields is fixed, thereby limiting the treatment effect.
The application provides a generating device and a control device of a target electric field, which aim to solve the technical problems in the prior art.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments. Embodiments of the present application will be described below with reference to the accompanying drawings.
The embodiment of the present application provides a device for generating a target electric field, and fig. 1 shows a schematic diagram of a framework of the device for generating a target electric field, where the device for generating a target electric field includes: at least two groups of electrode pairs 1, an electric signal generating circuit 2 and a control circuit 3.
Specifically, at least two groups of electrode pairs 1 are arranged at the target biological tissue according to a design mode; the electric signal generating circuit 2 is electrically connected with at least two groups of electrode pairs 1 and is used for outputting electric signals to each group of electrode pairs; n in the figure is an integer not less than 2; the control circuit 3 is electrically connected with the electric signal generating circuit 2 and the at least two groups of electrode pairs 1 and is used for controlling the electric signals so as to adjust the intensity and/or direction of the electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding target biological tissues. The target biological tissue includes human body, animal body, etc.
Optionally, the at least two electrode pairs 1 include at least two electrode patch pairs, and the at least two electrode patch pairs may be attached to the target region of the human or animal body according to a design manner.
Optionally, the control circuit 3 includes at least two control sub-circuits, and the at least two control sub-circuits are electrically connected to the at least two sets of electrode pairs 1 in a one-to-one correspondence.
Alternatively, the control Circuit 3 may be a CPU (Central Processing Unit), a general-purpose Processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field-Programmable Gate Array) or other Programmable logic device, a transistor logic device, a hardware component, or any combination thereof. Which may implement or perform the various illustrative logical blocks, modules, and circuits described in connection with the disclosure. The control circuit 3 may also be a combination for performing a computing function, e.g. comprising one or more microprocessors in combination, a DSP and a microprocessor in combination, etc.
The generation device of target electric field that this application embodiment provided, can control the electric signal that electric signal generating circuit 2 exported to at least two sets of electrode pairs 1 through control circuit 3, with the intensity and/or the direction of adjusting every group electrode pair electric field, and then obtain the electric field in a plurality of different directions, make the direction of the target electric field that each group electrode pair vectorization's each direction of electric field stack formed can change, for example the target electric field can be a rotatory electric field, make the regional target biological tissue can be covered by the changeable target electric field comprehensive scanning of direction, the treatment to the target biological tissue has been improved. I.e., a therapeutic effect in which the TT field is increased to prevent proliferation of and destroy rapidly proliferating viable cells (e.g., cancer cells).
Meanwhile, when the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the division degree of pathological cells to avoid damaging healthy cells.
In some embodiments, the control circuit 3 is further configured to control the phase of the electrical signals output to each group of electrode pairs, so that the electrical signals received by each group of electrode pairs are out of phase.
In some embodiments, the phase difference of the electrical signals received by two adjacent groups of electrode pairs is 360:2n, and n is an integer not less than 2.
Illustratively, when n is 2, the phase difference of the electrical signals received by two adjacent sets of electrode pairs is 90 °.
Illustratively, when n is 3, the phase difference of the electrical signals received by two adjacent sets of electrode pairs is 60 °.
In some embodiments, the control circuit 3 is further configured to control the voltage of the electrical signal output to each set of electrode pairs, so that the electric field formed by each set of electrode pairs reaches the designed electric field strength.
In some embodiments, the means for generating the target electric field further comprises at least one of:
the control circuit 3 is further configured to periodically control the phase of the electrical signal corresponding to each group of electrode pairs, so that the direction of the target electric field changes counterclockwise or clockwise.
And simultaneously transmitting the electric signals with the adjusted phases and/or intensities to each group of electrode pairs so that each group of electrode pairs simultaneously generate an electric field.
The generation device of target electric field that this application embodiment provided, can control the electric signal that electric signal generating circuit 2 exported to at least two sets of electrode pairs 1 through control circuit 3, with the intensity and/or the direction of adjusting every group electrode pair electric field, and then obtain the electric field in a plurality of different directions, make the direction of the target electric field that each group electrode pair vectorization's each direction of electric field stack formed can change, for example the target electric field can be a rotatory electric field, make the regional target biological tissue can be covered by the changeable target electric field comprehensive scanning of direction, the treatment to the target biological tissue has been improved. I.e., a therapeutic effect in which the TT field is increased to prevent proliferation of and destroy rapidly proliferating viable cells (e.g., cancer cells).
Meanwhile, when the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the division degree of pathological cells to avoid damaging healthy cells.
In some embodiments, the electrical signal generating circuit 2 includes: an alternating current signal generating circuit, or a pulsed electrical signal generating circuit. An alternating current signal generating circuit for generating an alternating current signal; and the pulse electric signal generating circuit is used for generating a pulse electric signal.
Alternatively, when the electrical signal generating circuit 2 is a pulse electrical signal generating circuit, the plurality of vector pulse signals generated by the pulse electrical signal generating circuit may be output at intervals, that is, the electric fields formed by the plurality of vector pulse signals exist independently and are not vector-superposed with each other; the output can also be carried out simultaneously, namely, the vector superposition between electric fields formed by a plurality of vector pulses is called a resultant electric field, namely, the coupled electric field.
Alternatively, when the electrical signal generating circuit 2 is an ac electrical signal generating circuit, the ac electrical signals generated by the ac electrical signal generating circuit may be output simultaneously, that is, substantially, a vector superposition between electric fields formed by a plurality of ac electrical signals is called a combined electric field, that is, a coupled electric field.
In some embodiments, as shown in fig. 2, at least two sets of electrode pairs 1 comprise: a first set of electrode pairs 11 and a second set of electrode pairs 12; a first group of electrode pairs 11 and a second group of electrode pairs 12, which are arranged around the target biological tissue according to a design orientation; the control circuit 3 includes: a first control sub-circuit 31 and a second control sub-circuit 32.
The first control sub-circuit 31 controls the voltage magnitude and phase of the electrical signals transmitted to the first group of electrode pairs 11 such that the first electric field generated by the first group of electrode pairs 11 reaches the first design electric field strength and the first design electric field direction.
The second control sub-circuit 32 controls the voltage magnitude and phase of the electrical signals transmitted to the second group of electrode pairs 12 so that the second electric field generated by the second group of electrode pairs 12 reaches a second design electric field strength and a second design electric field direction.
In some embodiments, the strength of the first electric field and the strength of the second electric field are both above 0 volts per centimeter (V/cm) and below 10 volts per centimeter (V/cm); the direction of the first electric field is vertical to that of the second electric field; the intensity of the coupled first electric field and the second electric field is more than 2 volts per centimeter (V/cm) and is higher than that of the coupled second electric field
Volts per centimeter (V/cm) or less; the direction of the electric field after the first electric field and the second electric field are coupled is more than 0 DEG and less than 360 deg.
Exemplarily, as shown in fig. 3, fig. 3 is a schematic structural diagram of two sets of electrode pairs provided in the embodiment of the present application and having an electric field at the same time. In fig. 3, E2 is the first electric field generated by the first group of electrode pairs 11, E1 is the second electric field generated by the second group of electrode pairs 12, and E is the target electric field after the first electric field E2 and the second electric field E1 are coupled, as shown in table one and table two. Also shown in fig. 3 are the directions of the first E2 and second E2 electric fields, and the central origin O of coordinates X, Y, X and Y axes.
Table one: the target electric field after the coupling of the two groups of electrode pairs changes along the counterclockwise direction
In Table 1, the first control sub-circuit 31 controls the electric signals outputted to the first group of electrode pairs 11 such that the intensity and direction of the first electric field E2 generated by the first group of electrode pairs 11 are 5V/cm and 360 degrees, respectively, the second control sub-circuit 32 controls the intensity and direction of the second electric field E1 generated by the first group of electrode pairs 12 to be 5V/cm and 270 degrees, respectively, the first electric field E2 and the second electric field E1The intensity and direction of the target electric field E after the electric field E1 is coupled are respectively
And 315. The strength and the direction of the target electric field E are adjusted by adjusting the strength and the direction of the first electric field E2 and the second electric field E1, so that the target biological tissue area can be fully scanned and covered by the target electric field with variable direction, and simultaneously, the strength of the target electric field E formed by vector superposition of the first electric field E2 and the second electric field E1 is also adjustable.
In table one, reference numerals 2 to 9 are repeated according to the above description, and it can be seen from table one that the direction of the target electric field E changes from 315 ° to 0 ° (i.e., the target electric fields E in table one are 315 ° 270 ° 225 ° 180 ° 135 ° 90 ° 45 ° 300 °, respectively), and the target electric field E rotates counterclockwise.
Table two: the target electric field after the coupling of the two groups of electrode pairs changes in the clockwise direction
In table two, numbered 1, the first control sub-circuit 31 controls the electrical signals output to the first set of electrode pairs 11 such that the strength and direction of the first electric field E2 generated by the first set of electrode pairs 11 are 5V/cm and 360 ° respectively, the second control sub-circuit 32 controls the strength and direction of the second electric field E1 generated by the first set of electrode pairs 12 to be 0V/cm and 90 ° respectively, and the strength and direction of the target electric field E after the first electric field E2 and the second electric field E1 are coupled to be 5V/cm and 0 ° respectively. The strength and the direction of the target electric field E are adjusted by adjusting the strength and the direction of the first electric field E2 and the second electric field E1, so that the target biological tissue area can be fully scanned and covered by the target electric field with variable direction, and simultaneously, the strength of the target electric field E formed by vector superposition of the first electric field E2 and the second electric field E1 is also adjustable.
In table two, numbers 2 to 9 are analogized according to the above description, and it can be seen from the above table two that the direction of the target electric field E changes from 0 ° to 315 ° (i.e. the target electric field E in table two is 0 ° 30 ° 45 ° 90 ° 135 ° 180 ° 225 ° 270 ° 315 °, respectively), and the target electric field E rotates clockwise.
Tables one and two show, by way of example only, that the target electric field E achieves rotation in the counterclockwise and clockwise directions, respectively. According to the table, the electric fields in a plurality of different directions are obtained by adjusting the strength and the direction of the electric fields of the two groups of electrode pairs, so that the direction of a target electric field formed by superimposing the electric fields of the groups of electrode pairs vectorized in all directions can be changed, for example, the target electric field can be a rotating electric field, so that a target biological tissue area can be fully scanned and covered by the target electric field with variable direction, and the treatment effect on the target biological tissue is improved. I.e., a therapeutic effect in which the TT field is increased to prevent proliferation of and destroy rapidly proliferating viable cells (e.g., cancer cells).
Meanwhile, when the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the division degree of pathological cells to avoid damaging healthy cells.
Based on the same inventive concept, an embodiment of the present application provides a method for controlling a target electric field, which is applied to a target electric field generating apparatus of any of the above embodiments, and includes:
controlling the electric signals output to the at least two groups of electrode pairs 1 by the electric signal generating circuit 2 to adjust the intensity and/or direction of the electric field of each group of electrode pairs so that each group of electrode pairs forms a target electric field at least surrounding target biological tissues; the generating device comprises an electric signal generating circuit 2 and at least two groups of electrode pairs 1 which are electrically connected.
According to the control method of the target electric field provided by the embodiment of the application, the electric signals output by the electric signal generation circuit 2 to the at least two groups of electrode pairs 1 can be controlled through the control circuit 3, so that the strength and/or direction of the electric field of each group of electrode pairs can be adjusted, and further, electric fields in a plurality of different directions can be obtained, so that the direction of the target electric field formed by the electric fields in all directions of vectorization of each group of electrode pairs can be changed, for example, the target electric field can be a rotating electric field, so that a target biological tissue area can be completely scanned and covered by the target electric field with the changeable direction, and the treatment effect on the target biological tissue is improved. I.e., a therapeutic effect in which the TT field is increased to prevent proliferation of and destroy rapidly proliferating viable cells (e.g., cancer cells).
Meanwhile, when the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the division degree of pathological cells to avoid damaging healthy cells.
In some embodiments, as shown in fig. 4, controlling the electrical signals output by the electrical signal generating circuit 2 to the at least two sets of electrode pairs 1 to adjust the strength and/or direction of the electric field of each set of electrode pairs such that each set of electrode pairs forms a target electric field at least surrounding a target biological tissue includes:
step S11: and controlling the phase of the electric signals output to each group of electrode pairs so that the electric signals received by each group of electrode pairs have phase difference.
In some embodiments, as shown in fig. 4, controlling the electrical signals output by the electrical signal generating circuit 2 to the at least two sets of electrode pairs 1 to adjust the strength and/or direction of the electric field of each set of electrode pairs such that each set of electrode pairs forms a target electric field at least surrounding a target biological tissue includes:
step S12: and controlling the voltage of the electric signal output to each group of electrode pairs, so that the electric field formed by each group of electrode pairs reaches the designed electric field strength.
In some embodiments, as shown in fig. 4, the electrical signals output by the electrical signal generating circuit 2 to the at least two sets of electrode pairs 1 are controlled to adjust the strength and/or direction of the electric field of each set of electrode pairs, so that each set of electrode pairs forms a target electric field at least surrounding the target biological tissue, including at least one of:
step S13: and periodically controlling the phase of the electric signal corresponding to each group of electrode pairs, so that the direction of the target electric field changes along the anticlockwise direction or the clockwise direction.
Step S14: and simultaneously transmitting each electric signal after the phase and/or the intensity are adjusted to each group of electrode pairs, so that each group of electrode pairs simultaneously generate an electric field, wherein the electric signals comprise: an alternating current signal or a pulsed electrical signal.
In fig. 4, steps S11, S12, S13, and S14 may be implemented in the order in the drawing, merely as an example.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
(1) according to the generation device and the control method for the target electric field, the electric signals output to at least two groups of electrode pairs 1 by the electric signal generation circuit 2 can be controlled by the control circuit 3, so that the strength and/or the direction of the electric field of each group of electrode pairs can be adjusted, and further, electric fields in a plurality of different directions can be obtained, so that the direction of the target electric field formed by the electric fields in all directions of vectorization of each group of electrode pairs can be changed, for example, the target electric field can be a rotating electric field, so that a target biological tissue region can be completely scanned and covered by the target electric field with the changeable direction, and the treatment effect on the target biological tissue is improved. I.e., a therapeutic effect in which the TT field is increased to prevent proliferation of and destroy rapidly proliferating viable cells (e.g., cancer cells).
(2) When the intensity of the electric field of each group of electrode pairs can be adjusted, the intensity of the target electric field formed by the superposition of the electric field vectors can be adjusted, so that different target electric field intensities can be adjusted based on the actual condition of the target biological tissue, for example, different electric field intensities can be adjusted according to the degree of pathological cell division to avoid damaging healthy cells.
Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (12)
1. An apparatus for generating an electric field of interest, comprising:
at least two groups of electrode pairs, which are used for being arranged at the target biological tissue according to a design mode;
the electric signal generating circuit is electrically connected with the at least two groups of electrode pairs and is used for outputting electric signals to each group of electrode pairs;
and the control circuit is electrically connected with the electric signal generating circuit and the at least two groups of electrode pairs and is used for controlling the electric signals so as to adjust the strength and/or direction of an electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding the target biological tissue.
2. The apparatus for generating an electric field of an object according to claim 1,
the control circuit is also used for controlling the phase of the electric signals output to each group of the electrode pairs, so that the electric signals received by each group of the electrode pairs have phase difference.
3. The apparatus for generating an electric field of an object according to claim 2,
the phase difference of the electric signals received by the two adjacent groups of electrode pairs is 360:2n, and n is an integer not less than 2.
4. The apparatus for generating an electric field of an object according to claim 1,
the control circuit is also used for controlling the voltage of the electric signal output to each group of the electrode pairs, so that the electric field formed by each group of the electrode pairs reaches the designed electric field strength.
5. The apparatus for generating an electric field of interest according to claim 1, further comprising at least one of:
the control circuit is also used for periodically controlling the phase of the electric signal corresponding to each group of the electrode pairs, so that the direction of the target electric field changes along the anticlockwise direction or the clockwise direction;
and simultaneously transmitting each electric signal after the phase and/or the intensity are adjusted to each group of electrode pairs, so that each group of electrode pairs simultaneously generate an electric field.
6. The apparatus for generating an electric field of a target according to claim 5, wherein the electric signal generating circuit comprises:
an alternating current signal generating circuit for generating an alternating current signal; alternatively, the first and second electrodes may be,
and the pulse electric signal generating circuit is used for generating a pulse electric signal.
7. The apparatus for generating an electric field of an object according to claim 5,
the at least two sets of electrode pairs comprise: a first set of electrode pairs and a second set of electrode pairs;
the first group of electrode pairs and the second group of electrode pairs are arranged around the target biological tissue according to a design position;
the control circuit includes: a first control sub-circuit and a second control sub-circuit;
the first control sub-circuit controls the voltage and the phase of the electric signals transmitted to the first group of electrode pairs, so that a first electric field generated by the first group of electrode pairs reaches a first design electric field strength and a first design electric field direction;
the second control sub-circuit controls the voltage and the phase of the electric signals transmitted to the second group of electrode pairs, so that a second electric field generated by the second group of electrode pairs reaches a second design electric field strength and a second design electric field direction.
8. The apparatus for generating an electric field of an object according to claim 7,
the intensity of the first electric field and the intensity of the second electric field are both above 0 volts per centimeter and below 10 volts per centimeter;
the direction of the first electric field is vertical to the direction of the second electric field;
the intensity of the coupled first electric field and the second electric field is more than 2 volts per centimeter
Volts per centimeter or less;
the direction of the electric field after the first electric field and the second electric field are coupled is more than 0 DEG and less than 360 deg.
9. A control method of a target electric field applied to the target electric field generating apparatus according to any one of claims 1 to 8, comprising:
controlling the electric signals output by the electric signal generating circuit to at least two groups of electrode pairs so as to adjust the strength and/or direction of the electric field of each group of electrode pairs, so that each group of electrode pairs forms a target electric field at least surrounding target biological tissues; the generating device comprises the electric signal generating circuit and the at least two groups of electrode pairs which are electrically connected.
10. The method of claim 9, wherein the controlling the electrical signals output from the electrical signal generating circuit to at least two sets of electrode pairs to adjust the intensity and/or direction of the electrical field of each set of electrode pairs such that each set of electrode pairs forms a target electrical field at least surrounding a target biological tissue comprises:
and controlling the phase of the electric signals output to each group of the electrode pairs so that the electric signals received by each group of the electrode pairs have a phase difference.
11. The method of claim 9, wherein the controlling the electrical signals output from the electrical signal generating circuit to at least two sets of electrode pairs to adjust the intensity and/or direction of the electrical field of each set of electrode pairs such that each set of electrode pairs forms a target electrical field at least surrounding a target biological tissue comprises:
and controlling the voltage of the electric signal output to each group of the electrode pairs, so that the electric field formed by each group of the electrode pairs reaches the designed electric field strength.
12. The method of claim 9, wherein the controlling the electrical signals output from the electrical signal generating circuit to at least two sets of electrode pairs adjusts the intensity and/or direction of the electrical field of each set of electrode pairs such that each set of electrode pairs forms a target electrical field at least surrounding a target biological tissue, the method comprising at least one of:
the phase of the electric signal corresponding to each group of the electrode pairs is periodically controlled, so that the direction of the target electric field changes along the anticlockwise direction or the clockwise direction;
simultaneously transmitting each of the phase and/or intensity adjusted electrical signals to each set of electrode pairs so that each set of electrode pairs simultaneously generates an electric field, the electrical signals comprising: an alternating current signal or a pulsed electrical signal.
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