CN113616372A - Fixer for constructing mouse photoaging model - Google Patents

Abstract

The invention discloses a fixer for constructing a mouse photoaging model, which is characterized by comprising a base, a fixed cylinder fixed on the base and an arc-shaped pressing sheet arranged on the same central line with the fixed cylinder, wherein the fixed cylinder is fixed on the base; the fixed cylinder and the arc-shaped pressing sheet form a group of fixing devices, and a plurality of groups of fixing devices are arranged on the base; the invention has the beneficial effects that: the instrument shields the head of the mouse and avoids the influence of repeated ultraviolet radiation on the eyesight of the mouse. The instrument fixes the position of the mouse by fixing the head of the mouse, thereby avoiding the influence of free movement, standing and the like on the radiation dose received by the mouse. The mice of the device can not be contacted, so that the dose influence caused by mutual contact and shielding is avoided. The instrument does not contact the head of a mouse in the whole process, so that the risk of biting is avoided. The mouse does not need anesthesia, and the damage of repeated anesthesia to the mouse is reduced. The apparatus can treat multiple mice simultaneously.

Description

Fixer for constructing mouse photoaging model

Technical Field

The invention relates to the technical field of medical instruments, in particular to a fixator for constructing a mouse photoaging model.

Background

In recent years, how to delay skin aging becomes a hot spot of current plastic cosmetic surgery research, and it is currently widely believed that photoaging is an important cause of skin aging. The research on the photoaging mechanism and the exploration of the method for delaying the photoaging need to establish a mouse back skin photoaging model by using ultraviolet radiation.

The establishment of the model has the following requirements: first, chronic radiation modeling requires that a dose of uv radiation be received daily for a number of consecutive days. In addition, in order to ensure successful modeling, the radiation quantity received by the back of the mouse at each irradiation needs to meet certain requirements, so that the movement of the mouse is reduced as much as possible in the irradiation process, and the mice are prevented from standing, contacting with each other and being shielded. In addition, the vision of the mouse is seriously affected and even blindness is caused by long-term large-dose ultraviolet radiation, the normal physiological activity of the mouse is seriously affected, and the experimental result is influenced.

However, there is no operating device that satisfies the above conditions. The current method commonly used is to anaesthetize the mouse or to avoid the mouse standing with a lower cage, and to radiate the mouse after standing an ultraviolet lamp above it. However, this approach has a number of problems:

1. the head of the mouse is exposed to high-dose ultraviolet radiation for a long time, so that blindness of the mouse can be caused, normal physiological activities of the mouse are seriously influenced, and experimental results are influenced.

2. Some experimental modeling requires several consecutive days of exposure to multiple uv radiation. If repeated anesthesia seriously affects the normal physiological state of the mouse, the accuracy of the experimental result is affected.

3. Even if the short cage limits the mouse to stand, if the short cage is not fixed, the mouse can still move freely in the cage, so that the radiation doses of different mice are possibly inconsistent, and the accuracy of the experimental result is influenced.

Disclosure of Invention

The invention aims to solve the defects in the prior art and provides a fixator for constructing a mouse photoaging model.

In order to achieve the purpose, the invention adopts the following technical scheme:

a fixer for constructing a mouse photoaging model is characterized by comprising a base, a fixed cylinder fixed on the base, and an arc-shaped pressing sheet arranged on the same central line with the fixed cylinder; the fixed cylinder and the arc-shaped pressing sheet form a group of fixing devices, and a plurality of groups of fixing devices are arranged on the base;

a vertical bar hole is arranged right above the fixed cylinder, and a transverse bar hole is arranged at the front end of the fixed cylinder;

one side of the arc-shaped pressing sheet is fixedly connected with a fixing plate, and the fixing plate is fixed on the base through screws.

Furthermore, a screw hole matched with the screw is formed in the base, and thread blocking pieces are arranged on the upper side and the lower side of the screw hole respectively.

Furthermore, a layer of silica gel pad is arranged at the inner arc of the arc-shaped pressing sheet.

Furthermore, a baffle plate is inserted into the cross bar hole on the fixed cylinder, and a plurality of air holes are formed in the baffle plate; the top of the baffle is connected with a shielding plate, and the baffle is perpendicular to the shielding plate.

Compared with the prior art, the invention has the beneficial effects that:

1. the instrument shields the head of the mouse and avoids the influence of repeated ultraviolet radiation on the eyesight of the mouse.

2. The instrument fixes the position of the mouse by fixing the head of the mouse, thereby avoiding the influence of free movement, standing and the like on the radiation dose received by the mouse.

3. The mice of the device can not be contacted, so that the dose influence caused by mutual contact and shielding is avoided.

4. The instrument does not contact the head of a mouse in the whole process, so that the risk of biting is avoided.

5. The mouse does not need anesthesia, and the damage of repeated anesthesia to the mouse is reduced.

6. The apparatus can treat multiple mice simultaneously.

Drawings

FIG. 1 is a schematic diagram of the overall structure of the technical scheme;

FIG. 2 is a schematic diagram of the overall structure of the present invention;

FIG. 3 is a schematic structural diagram of a fixing cylinder according to the present embodiment;

FIG. 4 is a schematic view of an arc-shaped tablet structure according to the present embodiment;

FIG. 5 is a schematic view of the structure of the baffle according to the present invention;

FIG. 6 is a schematic view of a shutter structure according to the present invention;

in the figure: 1. a base; 11. a screw hole; 2. a fixed cylinder; 21. a vertical bar hole; 22. a transverse bar hole; 3. arc-shaped pressing sheets; 31. a screw; 32. a threaded retaining piece; 33. a silica gel pad; 34. a fixing plate; 4. a baffle plate; 41. air holes are formed; 5. a shutter.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Example one

Referring to fig. 1-6, a fixer for constructing a mouse photoaging model is characterized by comprising a base 1, a fixed cylinder 2 fixed on the base 1, and an arc-shaped pressing sheet 3 arranged on the same central line with the fixed cylinder 2; the fixed cylinder 2 and the arc-shaped pressing sheet 3 form a group of fixing devices, and a plurality of groups of fixing devices are arranged on the base 1;

a vertical bar hole 21 is arranged right above the fixed cylinder 2, and a transverse bar hole 22 is arranged at the front end of the fixed cylinder 2;

one side of the arc-shaped pressing sheet 3 is fixedly connected with a fixing plate 34, and the fixing plate 34 is fixed on the base 1 through a screw 31. The screw 31 is provided with a handle for easy rotation.

When using this technical scheme, the operator is towards base 1, and fixed cylinder 2 is in the front, and arc preforming 3 is in the back, and the mouse tail is grabbed in one hand to the operator, makes the tail pass through vertical bar hole 21, with the mouse by preceding fixed cylinder 2 that pulls in backward. The tail passes through the vertical bar hole 21 and then enters the arc of the arc-shaped pressing sheet 8 through the fixed cylinder 2, and the tail is continuously pulled. When the mouse moves to a proper position, namely the chest is exposed from the tail end of the fixed cylinder 2 and reaches the lower part of the arc-shaped pressing sheet 8, the other hand adjusts the screw 31, so that the screw 31 drives the arc-shaped pressing sheet 3 to move downwards, the upper half body of the mouse is tightly fixed through the silica gel pad 9, then the baffle plate 4 is vertically inserted downwards into the fixed cylinder 2 through the cross bar hole 22, the head end of the mouse is sealed at the moment, the chest is fixed, the baffle plate 4 is inserted, the shielding plate 5 is driven to cover the upper part of the fixed cylinder 2, and the head of the mouse is shielded at the moment. In the same way, a plurality of mice can be simultaneously fixed on the base 1 and ultraviolet radiation is carried out.

Example two

Based on the first embodiment, the base 1 is provided with the screw hole 11 used in cooperation with the screw, and the upper and lower sides of the screw hole 11 are respectively provided with the thread blocking piece 32. Two thread blocking pieces 32 are added on two sides of the screw hole 11 to better play a role in fixing, and the arc-shaped pressing piece 3 is prevented from shaking.

EXAMPLE III

Based on the first embodiment, a layer of silica gel pad 33 is arranged at the inner arc of the arc-shaped pressing sheet 3. The silica gel pad 33 is arranged to avoid the injury to the mouse.

Example four

Based on the first embodiment, a baffle plate 4 is inserted into the transverse strip hole 22 on the fixed cylinder 2, and a plurality of air holes 41 are formed in the baffle plate 4; the top of the baffle 4 is connected with a shielding plate 5, and the baffle 4 is vertical to the shielding plate 5. The transverse bar holes 22 are arranged for conveniently inserting the baffle plates 4, and the air holes 41 prevent the mice from being irritated due to insufficient oxygen supply. The shielding plate 5 can well prevent ultraviolet rays from irradiating the mouse body due to the vertical bar holes 21.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (4)

1. A fixer for constructing a mouse photoaging model is characterized by comprising a base (1), a fixed cylinder (2) fixed on the base (1) and an arc-shaped pressing sheet (3) arranged on the same central line with the fixed cylinder (2); the fixed cylinder (2) and the arc-shaped pressing sheet (3) form a group of fixing devices, and a plurality of groups of fixing devices are arranged on the base (1);

a vertical bar hole (21) is formed right above the fixed cylinder (2), and a transverse bar hole (22) is formed at the front end of the fixed cylinder (2);

one side of the arc-shaped pressing sheet (3) is fixedly connected with a fixing plate (34), and the fixing plate (34) is fixed on the base (1) through a screw (31).

2. The fixator for constructing the mouse photoaging model is characterized in that the base (1) is provided with a screw hole (11) used in cooperation with the screw, and the upper and lower sides of the screw hole (11) are respectively provided with a thread stop piece (32).

3. The fixator for constructing the mouse photoaging model according to claim 1, wherein a layer of silica gel pad (33) is arranged at the inner arc of the arc-shaped pressing sheet (3).

4. The fixator for constructing the mouse photoaging model is characterized in that a baffle plate (4) is inserted into a transverse strip hole (22) on the fixing cylinder (2), and a plurality of air holes (41) are formed in the baffle plate (4); baffle (4) top is connected with sunshade (5), baffle (4) with sunshade (5) are perpendicular.

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